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AGPAT2 Gene

protein-coding GIFtS: 63

GC09M138687

1-acylglycerol-3-phosphate O-acyltransferase 2 (lysophosphatidic acid acyltransferase, beta)
(Previous name: Berardinelli-Seip congenital lipodystrophy )
Symbol approved by the HUGO Gene Nomenclature Committee (HGNC) database
(Previous symbol: BSCL)

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc , and/or ⁷Ensembl, ⁸miRBase)
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Aliases
1-AGPAT2 ^²
BSCL ^², ⁵
BSCL1 ^², ⁵
EC 2.3.1.51 ^³
LPAAB ^², ⁵
LPAAT-beta ^², ³
OTTHUMP00000022595 ^²
OTTHUMP00000022596 ^²

Descriptions
1-AGP acyltransferase 2 ^², ³
1-AGPAT 2 ^³
1-acyl-sn-glycerol-3-phosphate acyltransferase beta ^²
1-acylglycerol-3-phosphate O-acyltransferase 2 ^², ³
1-acylglycerol-3-phosphate O-acyltransferase 2 (lysophosphatidic acid acyltransferase, beta) ^²
1-acylglycerol-3-phosphate O-acyltransferase 2 (lysophosphatidic acid acyltransferase-beta) ^²
Berardinelli-Seip congenital lipodystrophy ^¹
Lysophosphatidic acid acyltransferase beta ^³
lysophosphatidic acid acyltransferase-beta ^²

External Ids
HGNC: 325¹
Entrez Gene: 10555²
UniProtKB: O15120³
Ensembl: ENSG00000169692⁷

Search outside databases for aliases for AGPAT2 gene

Previous GC identifers: GC09M130790 GC09M131257 GC09M133008 GC09M134924 GC09M136843

(According to Entrez Gene, Wikipedia's Gene Wiki,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

EntrezGene summary for AGPAT2:

This gene encodes a member of the 1-acylglycerol-3-phosphate O-acyltransferase family. The protein

is located within the endoplasmic reticulum membrane and converts lysophosphatidic acid to

phosphatidic acid, the second step in de novo phospholipid biosynthesis. Mutations in this gene

have been associated with congenital generalized lipodystrophy (CGL), or Berardinelli-Seip

syndrome, a disease characterized by a near absence of adipose tissue and severe insulin

resistance. Alternate transcriptional splice variants, encoding different isoforms, have been

characterized. [provided by RefSeq]

UniProtKB/Swiss-Prot: PLCB_HUMAN, O15120

Function: Converts lysophosphatidic acid (LPA) into phosphatidic acid by incorporating an acyl

moiety at the sn-2 position of the glycerol backbone

Gene Wiki entry for AGPAT2

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 36),
and/or miRBase,
Genomic Views according to UCSC and Ensembl, Transcription factor binding sites according to SABiosciences)
About This Section

Genomic View:

UCSC Golden Path with GeneCards custom track

Transcription factor binding sites upstream to the AGPAT2 gene

Entrez Gene cytogenetic band: 9q34.3 Ensembl cytogenetic band: 9q34.3 HGNC cytogenetic band: 9q34.3

AGPAT2 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)

GeneLoc gene densities for chromosome 9 GeneLoc Exon Structure

GeneLoc location for GC09M138687: (about GC identifiers)

Start:	138,687,416 bp from pter
End:	138,701,732 bp from pter
Size:	14,317 bases
Orientation:	minus strand

RefSeq DNA sequence:

NC_000009.10 NT_024000.16

(According to ¹UniProtKB, and/or Ensembl, Phosphorylation sites according to ²Phosphosite, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Enzo Life Sciences, Abnova, OriGene and/or, Abcam,
Biochemical Assays by Invitrogen, Millipore, R&D Systems, Cell Signaling Technology, and/or Enzo Life Sciences, Ontologies according to Gene Ontology Consortium 01 Apr 2009 and Entrez Gene, Antibodies by Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Cell Signaling Technology, Abcam, Abnova, and/or Novus Biologicals)
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UniProtKB/Swiss-Prot: PLCB_HUMAN, O15120 (See protein sequence)

Recommended Name: 1-acyl-sn-glycerol-3-phosphate acyltransferase beta

Size: 278 amino acids; 30914 Da

Subcellular location: Membrane; Multi-pass membrane protein (Potential)

Secondary accessions: O00516 O15106 Q9BSV7 Q9BWR7

Alternative splicing: 2 isoforms: O15120-1 O15120-2

Post-translational modifications:

View phosphorylation sites using PhosphoSite²

REFSEQ proteins (2 alternative transcripts):

NP_001012745.1 NP_006403.2

ENSEMBL proteins:

ENSP00000360761 ENSP00000360759

Human Recombinant Proteins

	Browse Drug Discovery Central at Invitrogen for human recombinant proteins
	Browse Purified and Recombinant Proteins at Millipore
	Browse Human Recombinant Proteins at Sigma-Aldrich
	Browse R&D Systems for human recombinant proteins
	Browse recombinant and purified proteins available from Enzo Life Sciences
	Recombinant Proteins from Abcam (Agpat2)
	Human Recombinant Proteins from Abnova (AGPAT2)

Browse Origene for full length recombinant human proteins expressed in human HEK293 cells

4 Gene Ontology (GO) cellular component terms (links to tree view):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005783	endoplasmic reticulum	ISS	--
GO:0005829	cytosol	EXP	9242711
GO:0016020	membrane	IEA	--
GO:0016021	integral to membrane	IEA	--

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Antibodies for AGPAT2:

	Browse Antibodies Central at Invitrogen
	Browse Millipore's Extensive Line of Mono- and Polyclonal Antibodies
	Sigma-Aldrich Antibodies for AGPAT2
	Browse R&D Systems for Antibodies
	Antibodies from Abcam (Agpat2), each with their Abpromise^SM
	Monoclonal and Polyclonal Antibodies from Abnova (AGPAT2)
	Novus Biologicals Antibodies for AGPAT2

Assays for AGPAT2:

	Browse Invitrogen for biochemical assays
	Browse Kits and Assays available from Millipore
	Browse R&D Systems for biochemical assays
	Browse biochemical assays available from Enzo Life Sciences

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

Graphical View of Domain Structure for InterPro Entry O15120

ProtoNet protein and cluster: O15120

2 Blocks protein families:

IPB000294 Vitamin K-dependent carboxylation/gamma-carboxyglutamic (GLA) domain

IPB002123 Phospholipid/glycerol acyltransferase

UniProtKB/Swiss-Prot: PLCB_HUMAN, O15120

Domain: The HXXXXD motif is essential for acyltransferase activity and may constitute the binding

site for the phosphate moiety of the glycerol-3-phosphate (By similarity)

Similarity: Belongs to the 1-acyl-sn-glycerol-3-phosphate acyltransferase family

(According to MGI Jun 06 2009, UniProtKB, IUBMB,and/or Genatlas,
shRNA from OriGene, Sigma-Aldrich, RNAi from Sigma-Aldrich,
RNAi Products, Clones, and Q-PCR Products from Invitrogen, Millipore, OriGene, and/or Abnova, siRNAs from Applied Biosystems, SYBR primers from OriGene, Cell-based Assays from Millipore, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
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Inhib. RNA:		Invitrogen RNAi Products for gene knock-down (AGPAT2)
		Browse for Gene Knock-down Tools from Millipore
		Abnova Chimera RNAi Products for Gene knock-down (AGPAT2)

OriGene 29mer shRNA kit in GFP-retroviral vectors (see all 2): NM_001012727

Applied Biosystems Silencer® siRNAs for AGPAT2

Sigma-Aldrich siRNA for AGPAT2

Sigma-Aldrich shRNA for AGPAT2

Explore Sigma-Aldrich super-pooled esiRNAs

Clones:		Invitrogen Clones for AGPAT2
		Browse Clones for the Expression of Recombinant Proteins Available from Millipore

OriGene GFP tagged cDNA clones in CMV expression vector (see all 2): NM_001012727
Myc/DDK tagged cDNA clones in CMV expression vector (see all 2): NM_001012727
untagged cDNA clones in CMV expression vector (see all 2): NM_001012727

Primers:

Browse Quantitative PCR Central at Invitrogen for Q-PCR LUX™ Primers

OriGene genome-wide validated SYBR primer pairs: NM_006412

UniProtKB/Swiss-Prot: PLCB_HUMAN, O15120

Function: Converts lysophosphatidic acid (LPA) into phosphatidic acid by incorporating an acyl

moiety at the sn-2 position of the glycerol backbone

Catalytic activity: Acyl-CoA + 1-acyl-sn-glycerol 3-phosphate = CoA + 1,2-diacyl-sn-glycerol

3-phosphate

Enzyme Number (IUBMB): EC 2.3.1.51

Genatlas biochemistry entry for AGPAT2:

lysophosphatidic acid acyltransferase (? beta),expressed in many tissues with highest expression in

liver,pancreas,heart

11 MGI mutant phenotypes (inferred from 1 allele) (MGI details for Agpat2):

adipose tissue	behavior/neurological	digestive/alimentary	endocrine/exocrine gland	hematopoietic system
homeostasis/metabolism	immune system	lethality-postnatal	life span-post-weaning/aging	liver/biliary system
renal/urinary system

4 Gene Ontology (GO) molecular function terms (links to tree view):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0003841	1-acylglycerol-3-phosphate O-acyltransferase activity	NAS	9461603
GO:0008415	acyltransferase activity	IEA	--
GO:0016740	transferase activity	IEA	--
GO:0046027	phospholipid:diacylglycerol acyltransferase activity	EXP	9242711

About this table

(Pathways according to Invitrogen (maps by GeneGo), Millipore, Cell Signaling Technology, Sigma-Aldrich, KEGG and/or UniProtKB,
Sets of similar genes according to GeneDecks, Proteins Network according to SABiosciences, Interactions according to ¹UniProtKB, ²MINT, and/or ³STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
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2 Sigma-Aldrich "Your Favorite Gene" Pathways for AGPAT2 (Your Favorite Gene powered by Ingenuity)

Glycerolipid Metabolism
Glycerophospholipid Metabolism

GeneDecks AGPAT2 for the pathways selected above

About GeneDecksing

UniProtKB/Swiss-Prot: PLCB_HUMAN, O15120

Pathway: Phospholipid metabolism; CDP-diacylglycerol biosynthesis; CDP-diacylglycerol from

sn-glycerol 3-phosphate: step 2/3

Gene Network Central^TM Interacting Genes and Proteins Network for AGPAT2

5/29 Interacting proteins for AGPAT2 (ENSP00000360761³) via UniProtKB, MINT, and/or STRING (see all 29 )

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
HNRNPUL2	ENSP00000301785³	STRING (score=.963)
AGPAT4	ENSP00000314036³	STRING (score=.922)
GPAM	ENSP00000265276³	STRING (score=.91)
AGK	ENSP00000347581³	STRING (score=.899)
CDS1	ENSP00000295887³	STRING (score=.899)

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3 Gene Ontology (GO) biological process terms (links to tree view):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0006654	phosphatidic acid biosynthetic process	TAS	9212163
GO:0008152	metabolic process	IEA	--
GO:0008654	phospholipid biosynthetic process	IEA	--

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(Chemical Compounds according to UniProtKB, Enzo Life Sciences, Sigma-Aldrich, Tocris Bioscience, and/or Novoseek and Drugs according to Enzo Life Sciences and/or PharmGKB)
About This Section

Browse drugs & compounds from Enzo Life Sciences

Browse Small Molecules at Sigma-Aldrich

Browse Tocris compounds for AGPAT2
2 Novoseek chemical compound relationships for AGPAT2 gene

Compound	Score	Articles	PubMed IDs for Articles with Shared Sentences (# sentences)
triacylglycerol	44.40	12	16495223 (4), 11967537 (1), 14557833 (1)
lipid	23.70	5	19278620 (2), 15841084 (1), 18458148 (1)

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(GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 219 Homo sapiens; Jun 2 2009) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView,
non coding RNAs according to RNAdb,
ESTs according to GeneTide,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from Invitrogen, Millipore, and/or Abnova,
siRNAs from Applied Biosystems, Sigma-Aldrich,
shRNA from Sigma-Aldrich, OriGene,
Tagged/untagged cDNA clones from OriGene,
Expression Assays from Applied Biosystems)
About This Section

Inhib. RNA:		Invitrogen RNAi Products for gene knock-down (AGPAT2)
		Browse for Gene Knock-down Tools from Millipore
		Abnova Chimera RNAi Products for Gene knock-down (AGPAT2)

OriGene 29mer shRNA kit in GFP-retroviral vectors (see all 2): NM_001012727

Sigma-Aldrich siRNA for AGPAT2

Sigma-Aldrich shRNA for AGPAT2

Explore Sigma-Aldrich super-pooled esiRNAs

Applied Biosystems Silencer® siRNAs:

NM_001012727 NM_006412

REFSEQ mRNAs for AGPAT2 gene (2 alternative transcripts):

NM_001012727.1 NM_006412.3

Applied Biosystems TaqMan ® Gene Expression Assays:

NM_001012727 NM_006412

               OriGene GFP tagged cDNA clones in CMV expression vector (see all 2): NM_001012727
                                 Myc/DDK tagged cDNA clones in CMV expression vector (see all 2): NM_001012727
                                 untagged cDNA clones in CMV expression vector (see all 2): NM_001012727

Additional cDNA sequence:

AF000237.1 AF011374.1 BC000026.2 BC004529.2 BC007269.1 BC019292.1 CR590402.1 CR590462.1

CR592360.1 CR597301.1 CR598618.1 CR601358.1 CR602303.1 CR603192.1 CR605868.1 CR611946.1

CR615685.1 CR623942.1 CR624126.1 CR625982.1 U56418.2

9 DOTS entries:

DT.92443814 DT.100811410 DT.91859871 DT.92443810 DT.95366130 DT.92443815 DT.100811408 DT.100811411

DT.92443809

24/378 AceView cDNA sequences (see all 378 ):

CR597301 BM921501 CR592360 BM767629 BM558647 CR603192 BE731016 BM460130

BM470261 BM069745 CR623942 AI611052 BI907617 AA814626 CR590402 AA877363

BM817796 BM045722 BI835051 BM914841 CR598618 CA488680 BM930900 BU541108

highest scoring ESTs for AGPAT2:

AF000237 AF011374 AL519660 AL527790 AL556351 AL564457 AW732472 BC000026 BC004529 BC019292

Unigene Cluster for AGPAT2:

1-acylglycerol-3-phosphate O-acyltransferase 2 (lysophosphatidic acid acyltransferase, beta)

Hs.320151 [show with all ESTs]

Unigene Representative Sequence: NM_006412

GeneLoc Exon Structure

3 Alternative Splicing Database (ASD) splice patterns (SP) for AGPAT2

ExUns:	1	^	2a	·	2b	^	3	^	4	^	5	^	6a	·	6b
SP1:					-
SP2:					-				-
SP3:

About this scheme

ECgene alternative splicing isoforms for AGPAT2

2 Ensembl transcripts including schematic representations:

ENST00000371696 ENST00000371694

(Experimental results according to ¹GeneNote and GNF BioGPS,
probe sets-to-genes annotations according to ²GeneAnnot , ³GeneTide , Sets of similar genes according to GeneDecks, Electronic Northern calculations according to data from UniGene (Build 219 Homo sapiens), SAGE tags according to CGAP, plus additional links to SOURCE, and/or GNF BioGPS, and/or EXPOLDB, and/or UniProtKB,
Expression Assays from Applied Biosystems )
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AGPAT2 expression in normal and diseased human tissues

Applied Biosystems TaqMan ® Gene Expression Assays for AGPAT2

¹ / ² / ³

8 probe-sets matching AGPAT2 gene

Affymetrix probe-set	Array	# genes	Sensitivity	Specificity	Correlation	Length	Gb_Accession	Consensus	Uniqueness	Score	Rank
Affymetrix probe-set	Array	GeneAnnot data			GeneNote data		GeneTide data
32837_at²^{, 3}	U133-A	1	1.00	1.00	0.86	0.90	U56418	0.80	1.00	0.91	1
58770_f_at²^{, 3}	U95-C	1	1.00	1.00	0.81	1.23	AI380624	0.40	1.00	0.76	1
58772_r_at²^{, 3}	U95-C	1	0.88	1.00	0.82	1.23	AI380624	0.40	1.00	0.76	1
58765_at²^{, 3}	U95-C	1	0.38	1.00	0.82	0.65	AW001559	0.60	1.00	0.82	1
32837_at²^{, 3}	U133-A	1	1.00	1.00	--	--	U56418	0.80	1.00	0.91	1
210678_s_at²^{, 3}	U133-A	1	1.00	1.00	--	--	U56418	0.80	1.00	0.91	1
32837_at²	U133Plus2	1	1.00	1.00	--	--	--	--	--	--	--
210678_s_at²	U133Plus2	1	1.00	1.00	--	--	--	--	--	--	--

GeneDecks AGPAT2 for binary patterns associated with the probe-sets selected above

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Data from

(Publications) and GNF BioGPS
About these images
About these images

CGAP SAGE TAG: ACCTGGGGAG

SOURCE GeneReport for Unigene cluster: Hs.320151
Expression variation in blood from EXPOLDB for AGPAT2
UniProtKB/Swiss-Prot: PLCB_HUMAN, O15120
Tissue specificity: Expressed predominantly in heart and liver

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD and/or ⁵MGI Jun 06 2009, with possible further links to Flybase and/or WormBase, Gene Trees according to Ensembl)
About This Section

Orthologs for AGPAT2 gene from 5/14 species (see all 14 )

Organism	Gene	Locus	Description	Human Similarity	NCBI accessions
dog (Canis familiaris)	AGPAT2¹	--	1-acylglycerol-3-phosphate O-acyltransferase 2 (lysophosphatidic more	81.19(n) 74.69(a)	491249 XM_548370.2 XP_548370.2
chimpanzee (Pan troglodytes)	AGPAT2¹	--	1-acylglycerol-3-phosphate O-acyltransferase 2 (lysophosphatidic more	97.6(n) 96.85(a)	748669 XM_001162511.1 XP_001162511.1
cow (Bos taurus)	AGPAT2¹	--	1-acylglycerol-3-phosphate O-acyltransferase 2 (lysophosphatidic more	83.57(n) 79.86(a)	512112 XM_589558.3 XP_589558.3
rat (Rattus norvegicus)	Agpat2¹	--	1-acylglycerol-3-phosphate O-acyltransferase 2 (lysophosphatidic more	79.02(n) 75.9(a)	311821 XM_231089.4 XP_231089.4
mouse (Mus musculus)	Agpat2^{1, 5}	2⁵	1-acylglycerol-3-phosphate O-acyltransferase 2 (lysophosphatidic more^{1, 5}	80.58(n)¹ 76.98(a)¹	67512¹ NM_026212.1¹ NP_080488.1¹ AK002422⁵ AK010891⁵ (see all 11)

About this table Species with no ortholog for AGPAT2

ENSEMBL Gene Tree for AGPAT2

(Paralogs according to ¹HomoloGene
and ²Ensembl, Pseudogenes according to ³Pseudogene.org)
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Paralogs for AGPAT2 gene

ENSG00000204310²

(According to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, and UniProtKB, Linkage Disequilibrium by HapMap, Genotyping Reagents from Applied Biosystems)
About This Section

10/104 NCBI SNPs in AGPAT2 are shown (see all 104 )
(Click for Applied Biosystems TaqMan ® Genotyping Assay) (see all 57)

AB	SNP ID	Valid	Chr 9 pos	Sequence	Recs	AA Chg	Type	More	Recs	Allele freq	Pop	Total sample	More
AB	Genomic Data				Transcription Data				Allele Frequencies
				--	--	--		--	--				--
	rs3812612^1,2	A,C,F,H	138703028(+)	`TGCTGG/TGCCTC`	2	--	ng3¹		3		EU EA	298
	rs3812611^1,2	A,C,F,H	138702976(+)	`CGCTTA/GGAGCC`	2	--	ng3¹		11		EA EU WA NA	2518
	rs878979^1,2	A,C,F,H	138703299(+)	`TTTACG/ATGCCA`	2	--	ng3¹		10		NA EA EU WA	742
	rs6951^1,2	A,C,F	138687583(-)	`TCAGGG/CTCTCT`	2	--	ut3¹ ese³		1		MN	184
	rs3812613^1,2	A,C,F	138703127(+)	`GCTGCC/TGGGAG`	2	--	ng3¹		1		EA	1494
	rs10320^1,2	A,C,F	138687508(-)	`GGAATT/CGGGGC`	2	--	ut3¹		2		MN	372
	rs4880119^1,2	A,C	138687868(+)	`CTGAGA/GCCAGT`	2	--	ut3¹ ese³		0	--	--	--	--
--	rs7038079^1,2	A,C	138702160(+)	`GGGGAC/TGCGCC`	2	--	ng3¹		0	--	--	--	--
--	rs9411263^1,2	C	138703059(+)	`GCTGAC/TGGCTG`	2	--	ng3¹		0	--	--	--	--
--	rs2385893^1,2	C	138701815(+)	`cccacA/Cacgcc`	2	--	ng3¹		0	--	--	--	--

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HapMap Linkage Disequilibrium images for AGPAT2 (up to first 250kb)

(in which this Gene is Involved, According to OMIM, UniProtKB, Novoseek, PharmGKB, Genatlas, GeneTests, Blood group antigen gene mutations by BGMUT, HGMD, GAD, HuGE Navigator, BCGD, and/or TGDB.)
About This Section

OMIM: 603100 disorders: 608594

UniProtKB/Swiss-Prot: PLCB_HUMAN, O15120

Defects in AGPAT2 are the cause of congenital generalized lipodystrophy type 1 (CGL1)

[MIM:608594]; also known as Berardinelli-Seip congenital lipodystrophy type 1 (BSCL1) or

Berardinelli-Seip syndrome. CGL1 is an autosomal recessive disorder characterized by marked

paucity of adipose tissue, extreme insulin resistance, hypertriglyceridemia, hepatic steatosis and

early onset of diabetes

7 Novoseek disease relationships for AGPAT2 gene

Disease	Score	Articles	PubMed IDs for Articles with Shared Sentences (# sentences)
lipodystrophy, congenital generalized	97.72	15	11967537 (2), 14557833 (1), 18057387 (1), 14557463 (1) (see all 11)
lipodystrophy	79.10	6	16409151 (1), 12788894 (1), 16722806 (1), 18698612 (1) (see all 5)
lipodystrophy, familial partial	75.25	1	14516935 (1)
insulin resistance	62.69	3	15908053 (1), 19026526 (1), 14516935 (1)
ovarian cancer	24.62	8	16230405 (2), 15841084 (1), 16944535 (1)
cancer	0.00	3	14498826 (1), 16488473 (1)
tumors	0.00	16	16944535 (7), 14578472 (4), 16230405 (1)

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GeneTests: AGPAT2

Berardinelli-Seip Congenital Lipodystrophy

Human Gene Mutation Database: AGPAT2

(Possibly Related Articles in Doctor's Guide)
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(in PubMed. Associations of this gene to articles via ¹Novoseek, ²HGNC, ³Entrez Gene, ⁴UniProtKB/Swiss-Prot, ⁵UniProtKB/TrEMBL, ⁶GAD, and/or ⁷PharmGKB)
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10/48 PubMed articles for AGPAT2 gene (see all 48 ):

Cloning and expression of two human lysophosphatidic acid acyltransferase cDNAs that enhance cytokine-induced signaling responses in cells. (PubMed id 9212163)^{1, 2, 3, 4} West J....Leung D.W. (1997)
Human lysophosphatidic acid acyltransferase. cDNA cloning, expression, and localization to chromosome 9q34.3. (PubMed id 9242711)^{2, 3, 4} Eberhardt C.... Tjoelker L.W. (1997)
AGPAT2 is mutated in congenital generalized lipodystrophy linked to chromosome 9q34. (PubMed id 11967537)^{1, 3, 4} Agarwal A.K.... Garg A. (2002)
Acquired and inherited lipodystrophies. (PubMed id 15028826)^{3, 4} Garg A. (2004)
The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)^{3, 4} Gerhard D.S....Malek J. (2004)
A human cDNA sequence with homology to non-mammalian lysophosphatidic acid acyltransferases. (PubMed id 9291118)^{3, 4} Stamps A.C....Finnen M.J. (1997)
Expression of lysophosphatidic acid acyltransferase beta (LPAAT-beta) in ovarian carcinoma: correlation with tumour grading and prognosis. (PubMed id 15841084)^{1, 3} Niesporek S....Hauptmann S. (2005)
Enzymatic activity of naturally occurring 1-acylglycerol-3-phosphate-O-acyltransferase 2 mutants associated with congenital generalized lipodystrophy. (PubMed id 15629135)^{1, 3} Haque W....Agarwal A.K. (2005)
Phenotypic heterogeneity in biochemical parameters correlates with mutations in AGPAT2 or Seipin genes among Berardinelli-Seip congenital lipodystrophy patients. (PubMed id 16435205)^{1, 3} Gomes K.B....Fernandes A.P. (2005)
Phenotypic heterogeneity in body fat distribution in patients with congenital generalized lipodystrophy caused by mutations in the AGPAT2 or seipin genes. (PubMed id 14602785)^{1, 3} Simha V. and Garg A. (2003)

(in PubMed, OMIM, and NCBI Bookshelf)
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		AND	OR
Aliases
Disorders
Free Text

Query String		PubMed OMIM NCBI Bookshelf
	(Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, and/or H-InvDB)
About This Section

Entrez Gene: 10555	HGNC: 325	AceView: AGPAT2	Ensembl:ENSG00000169692	euGenes: HUgn10555
ECgene: AGPAT2	H-InvDB: AGPAT2

(According to HUGE)
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(According to ATLAS, HORDE, IMGT, MTDB, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
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Name	Description
GeneReviews	http://www.genetests.org/query?gene=AGPAT2

Licensable Technologies for AGPAT2
(Available from WIS Yeda, Salk, Tufts)

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(Reagents available from Applied Biosystems, Antibodies and assays by Cell Signaling Technology, Abcam, Novus Biologicals,
Sigma-Aldrich, R&D Systems, Millipore, Abnova, and/or Invitrogen, Clones available from OriGene,and/or Invitrogen, Drugs and/or compounds by Sigma-Aldrich,
Enzo Life Sciences, and/or Tocris Bioscience)
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Products for AGPAT2:

TaqMan ® Gene Expression Assays

TaqMan ® Genotyping Assays

Free SNP selection tool

Invitrogen iPath Pathways	Invitrogen BLOCK-iT™ RNAi
Invitrogen Antibodies	Invitrogen Assays
Invitrogen Clones	Invitrogen Q-PCR Products
Invitrogen Human Recombinant Kinases	Invitrogen Custom Antibody and Peptide Service
Invitrogen Proteins / Assays / Screening Services	Search Invitrogen catalog for AGPAT2-related products

	Millipore Custom Antibody & Bulk Services
	Millipore Preclinical / Clinical Development Services
	Millipore Immunoassay Services
	Millipore Target Screening & Profiling Services

	Predesigned and custom siRNAs for AGPAT2		Antibodies for AGPAT2
	Explore super-pooled esiRNAs		Browse proteins at Sigma-Aldrich
	Lentivirus-delivered shRNAs for AGPAT2		Browse small molecules at Sigma-Aldrich
	"Your Favorite Gene" Pathways		feedback

	Antibodies		Primer Pairs
	Cell Culture Products		ELISAs
	Flow Cytometry Kits		Protease Activity Assays & Reagents
	Cell Selection/Detection Kits & Reagents		ELISA/Assay Development Kits & Reagents
	Multiplex/Array Assay Kits & Reagents		ELISpot Kits & Development Modules
	Recombinant & Natural Proteins

	Recombinant Proteins (AGPAT2)
	Antibodies (AGPAT2)
	Chimera RNAi (AGPAT2)
	Custom Service for Mouse Mab
	Custom Service for Rabbit Pab from Full-length Protein

Search for Antibodies & Assays

	Recombinant Proteins (Agpat2)
	Antibodies (Agpat2)

Search OriGene for AGPAT2

Search Tocris compounds for AGPAT2

Search www.enzolifesicences.com for proteins, assays, substrates, inhibitors & antibodies

Antibodies for AGPAT2

GeneCards Homepage - Last full update: 2 Jul 2009 Incremental update: 13 Oct 2009

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Gene Index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

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AGPAT2 Gene

protein-coding GIFtS: 63

Aliases &
Descriptions
for AGPAT2

Summaries
for AGPAT2

Genomic Location
for AGPAT2

Proteins
for AGPAT2

Protein Domains/
Families
for AGPAT2

Gene Function
for AGPAT2

Pathways & Interactions
for AGPAT2

Drugs & Compounds
for AGPAT2

Transcripts
for AGPAT2

Expression
for AGPAT2

Orthologs
for AGPAT2

Paralogs
for AGPAT2

SNPs/Variants
for AGPAT2

Disorders & Mutations
for AGPAT2

Medical News
for AGPAT2

Publications
for AGPAT2

Search for AGPAT2

Genome Databases showing AGPAT2

Other Databases showing AGPAT2

Specialized Databases showing AGPAT2

Licensable Technologies
for AGPAT2

Services
for AGPAT2

Gene Index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

AGPAT2 Gene

protein-coding GIFtS: 63

Aliases & Descriptionsfor AGPAT2

Summariesfor AGPAT2

Genomic Locationfor AGPAT2

Proteinsfor AGPAT2

Protein Domains/Familiesfor AGPAT2

Gene Functionfor AGPAT2

Pathways & Interactionsfor AGPAT2

Drugs & Compoundsfor AGPAT2

Transcriptsfor AGPAT2

Expression for AGPAT2

Orthologsfor AGPAT2

Paralogsfor AGPAT2

SNPs/Variantsfor AGPAT2

Disorders & Mutationsfor AGPAT2

Medical Newsfor AGPAT2

Publicationsfor AGPAT2

Search for AGPAT2

Genome Databases showing AGPAT2

Other Databases showing AGPAT2

Specialized Databases showing AGPAT2

Licensable Technologiesfor AGPAT2

Servicesfor AGPAT2

Gene Index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

Aliases &
Descriptions
for AGPAT2

Summaries
for AGPAT2

Genomic Location
for AGPAT2

Proteins
for AGPAT2

Protein Domains/
Families
for AGPAT2

Gene Function
for AGPAT2

Pathways & Interactions
for AGPAT2

Drugs & Compounds
for AGPAT2

Transcripts
for AGPAT2

Expression
for AGPAT2

Orthologs
for AGPAT2

Paralogs
for AGPAT2

SNPs/Variants
for AGPAT2

Disorders & Mutations
for AGPAT2

Medical News
for AGPAT2

Publications
for AGPAT2

Licensable Technologies
for AGPAT2

Services
for AGPAT2