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AGPAT2 Gene

protein-coding   GIFtS: 63

GC09M138687
1-acylglycerol-3-phosphate O-acyltransferase 2 (lysophosphatidic acid acyltransferase, beta)
(Previous name: Berardinelli-Seip congenital lipodystrophy )
Symbol approved by the HUGO Gene Nomenclature Committee (HGNC) database
(Previous symbol: BSCL)
Services    
(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc , and/or 7Ensembl, 8miRBase)
About This Section

Aliases
1-AGPAT2 2
BSCL 2, 5
BSCL1 2, 5
EC 2.3.1.51 3
LPAAB 2, 5
LPAAT-beta 2, 3
OTTHUMP00000022595 2
OTTHUMP00000022596 2
Descriptions
1-AGP acyltransferase 2 2, 3
1-AGPAT 2 3
1-acyl-sn-glycerol-3-phosphate acyltransferase beta 2
1-acylglycerol-3-phosphate O-acyltransferase 2 2, 3
1-acylglycerol-3-phosphate O-acyltransferase 2
(lysophosphatidic acid acyltransferase, beta) 2
1-acylglycerol-3-phosphate O-acyltransferase 2
(lysophosphatidic acid acyltransferase-beta) 2
Berardinelli-Seip congenital lipodystrophy 1
Lysophosphatidic acid acyltransferase beta 3
lysophosphatidic acid acyltransferase-beta 2
External Ids
HGNC: 3251
Entrez Gene: 105552
UniProtKB: O151203
Ensembl: ENSG000001696927
Search outside databases for aliases for AGPAT2 gene

Previous GC identifers: GC09M130790 GC09M131257 GC09M133008 GC09M134924 GC09M136843

(According to Entrez Gene, Wikipedia's Gene Wiki,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

EntrezGene summary for AGPAT2:
This gene encodes a member of the 1-acylglycerol-3-phosphate O-acyltransferase family. The protein
is located within the endoplasmic reticulum membrane and converts lysophosphatidic acid to
phosphatidic acid, the second step in de novo phospholipid biosynthesis. Mutations in this gene
have been associated with congenital generalized lipodystrophy (CGL), or Berardinelli-Seip
syndrome, a disease characterized by a near absence of adipose tissue and severe insulin
resistance. Alternate transcriptional splice variants, encoding different isoforms, have been
characterized. [provided by RefSeq]

UniProtKB/Swiss-Prot: PLCB_HUMAN, O15120
Function: Converts lysophosphatidic acid (LPA) into phosphatidic acid by incorporating an acyl
moiety at the sn-2 position of the glycerol backbone

Gene Wiki entry for AGPAT2

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 36),
and/or miRBase,
Genomic Views according to UCSC and Ensembl, Transcription factor binding sites according to SABiosciences)
About This Section

Genomic View:
UCSC Golden Path with GeneCards custom track

 Transcription factor binding sites upstream to the AGPAT2 gene  

Entrez Gene cytogenetic band: 9q34.3   Ensembl cytogenetic band:  9q34.3   HGNC cytogenetic band: 9q34.3

AGPAT2 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)

GeneLoc gene densities for chromosome 9         GeneLoc Exon Structure

GeneLoc location for GC09M138687:     (about GC identifiers)

Start:
138,687,416 bp from pter
End:
138,701,732 bp from pter
Size:
14,317 bases
Orientation:
minus strand
RefSeq DNA sequence:
NC_000009.10  NT_024000.16  
(According to 1UniProtKB, and/or Ensembl, Phosphorylation sites according to 2Phosphosite, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Enzo Life Sciences, Abnova, OriGene and/or, Abcam,
Biochemical Assays by Invitrogen, Millipore, R&D Systems, Cell Signaling Technology, and/or Enzo Life Sciences, Ontologies according to Gene Ontology Consortium 01 Apr 2009 and Entrez Gene, Antibodies by Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Cell Signaling Technology, Abcam, Abnova, and/or Novus Biologicals)
About This Section

UniProtKB/Swiss-Prot: PLCB_HUMAN, O15120 (See protein sequence)
Recommended Name: 1-acyl-sn-glycerol-3-phosphate acyltransferase beta  
Size: 278 amino acids; 30914 Da
Subcellular location: Membrane; Multi-pass membrane protein (Potential)
Secondary accessions: O00516 O15106 Q9BSV7 Q9BWR7
Alternative splicing: 2 isoforms:  O15120-1   O15120-2   

Post-translational modifications:

  • View phosphorylation sites using PhosphoSite2


  • REFSEQ proteins (2 alternative transcripts): 
    NP_001012745.1  NP_006403.2  


    ENSEMBL proteins: 
    ENSP00000360761 ENSP00000360759 


    Human Recombinant Proteins 
    Browse Drug Discovery Central at Invitrogen for human recombinant proteins
    Browse Purified and Recombinant Proteins at Millipore
    Browse Human Recombinant Proteins at Sigma-Aldrich  
    Browse R&D Systems for human recombinant proteins
    Browse recombinant and purified proteins available from Enzo Life Sciences
    Recombinant Proteins from Abcam (Agpat2)
    Human Recombinant Proteins from Abnova (AGPAT2)
                    Browse Origene for full length recombinant human proteins expressed in human HEK293 cells 

    4 Gene Ontology (GO) cellular component terms (links to tree view):

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005783 endoplasmic reticulum ISS--
    GO:0005829 cytosol EXP9242711
    GO:0016020 membrane IEA--
    GO:0016021 integral to membrane IEA--
    About this table

    Antibodies for AGPAT2: 
    Browse Antibodies Central at Invitrogen
    Browse Millipore's Extensive Line of Mono- and Polyclonal Antibodies
    Sigma-Aldrich Antibodies for AGPAT2
    Browse R&D Systems for Antibodies
    Antibodies from Abcam (Agpat2), each with their AbpromiseSM
    Monoclonal and Polyclonal Antibodies from Abnova (AGPAT2)
    Novus Biologicals Antibodies for AGPAT2

    Assays for AGPAT2: 
    Browse Invitrogen for biochemical assays
    Browse Kits and Assays available from Millipore
    Browse R&D Systems for biochemical assays
    Browse biochemical assays available from Enzo Life Sciences

    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section

    2 InterPro domains/families:
     IPR002123 Acyltransferase
     IPR004552 AGP_acyltrans


       GeneDecks  AGPAT2 for the domains selected above  
    About GeneDecksing

    Graphical View of Domain Structure for InterPro Entry O15120

    ProtoNet protein and cluster: O15120

    2 Blocks protein families:
    IPB000294 Vitamin K-dependent carboxylation/gamma-carboxyglutamic (GLA) domain
    IPB002123 Phospholipid/glycerol acyltransferase


    UniProtKB/Swiss-Prot: PLCB_HUMAN, O15120
    Domain: The HXXXXD motif is essential for acyltransferase activity and may constitute the binding
    site for the phosphate moiety of the glycerol-3-phosphate (By similarity)
    Similarity: Belongs to the 1-acyl-sn-glycerol-3-phosphate acyltransferase family

    (According to MGI Jun 06 2009, UniProtKB, IUBMB,and/or Genatlas,
    shRNA from OriGene, Sigma-Aldrich, RNAi from Sigma-Aldrich,
    RNAi Products, Clones, and Q-PCR Products from Invitrogen, Millipore, OriGene, and/or Abnova, siRNAs from Applied Biosystems, SYBR primers from OriGene, Cell-based Assays from Millipore, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
    About This Section

    Inhib.
    RNA:
    Invitrogen RNAi Products for gene knock-down (AGPAT2)
    Browse for Gene Knock-down Tools from Millipore
    Abnova Chimera RNAi Products for Gene knock-down (AGPAT2)
                   OriGene 29mer shRNA kit in GFP-retroviral vectors (see all 2): NM_001012727

                  Applied Biosystems Silencer® siRNAs for AGPAT2

                  Sigma-Aldrich siRNA for AGPAT2  
                         Sigma-Aldrich shRNA for AGPAT2  
                         Explore Sigma-Aldrich super-pooled esiRNAs  

    Clones:Invitrogen Clones for AGPAT2
    Browse Clones for the Expression of Recombinant Proteins Available from Millipore
                   OriGene GFP tagged cDNA clones in CMV expression vector (see all 2): NM_001012727
                                     Myc/DDK tagged cDNA clones in CMV expression vector (see all 2): NM_001012727
                                     untagged cDNA clones in CMV expression vector (see all 2): NM_001012727 

    Primers: Browse Quantitative PCR Central at Invitrogen for Q-PCR LUX™ Primers
                  OriGene genome-wide validated SYBR primer pairs: NM_006412

    UniProtKB/Swiss-Prot: PLCB_HUMAN, O15120
    Function: Converts lysophosphatidic acid (LPA) into phosphatidic acid by incorporating an acyl
    moiety at the sn-2 position of the glycerol backbone
    Catalytic activity: Acyl-CoA + 1-acyl-sn-glycerol 3-phosphate = CoA + 1,2-diacyl-sn-glycerol
    3-phosphate
    Enzyme Number (IUBMB): EC 2.3.1.51 

    Genatlas biochemistry entry for AGPAT2:
    lysophosphatidic acid acyltransferase (? beta),expressed in many tissues with highest expression in
    liver,pancreas,heart

    11 MGI mutant phenotypes (inferred from 1 allele(MGI details for Agpat2):

    adipose tissuebehavior/neurologicaldigestive/alimentaryendocrine/exocrine glandhematopoietic system
    homeostasis/metabolismimmune systemlethality-postnatallife span-post-weaning/agingliver/biliary system
    renal/urinary system

    4 Gene Ontology (GO) molecular function terms (links to tree view):

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003841 1-acylglycerol-3-phosphate O-acyltransferase activity NAS9461603
    GO:0008415 acyltransferase activity IEA--
    GO:0016740 transferase activity IEA--
    GO:0046027 phospholipid:diacylglycerol acyltransferase activity EXP9242711
    About this table

    (Pathways according to Invitrogen (maps by GeneGo), Millipore, Cell Signaling Technology, Sigma-Aldrich, KEGG and/or UniProtKB,
    Sets of similar genes according to GeneDecks, Proteins Network according to SABiosciences, Interactions according to 1UniProtKB, 2MINT, and/or 3STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
    About This Section

    1 Invitrogen iPath™ Online BioAtlas - Pathway for AGPAT2 (Maps provided by GeneGo):
     Triacylglycerol metabolism

       GeneDecks  AGPAT2 for the pathways selected above  
    About GeneDecksing

    2 Sigma-Aldrich "Your Favorite Gene" Pathways for  AGPAT2  (Your Favorite Gene powered by Ingenuity) 
     Glycerolipid Metabolism
     Glycerophospholipid Metabolism

       GeneDecks  AGPAT2 for the pathways selected above  
    About GeneDecksing

    3 Kegg Pathways  (Kegg details for AGPAT2):
     hsa00561 Glycerolipid metabolism
     hsa00564 Glycerophospholipid metabolism
     hsa00565 Ether lipid metabolism

       GeneDecks  AGPAT2 for the pathways selected above  
    About GeneDecksing
    UniProtKB/Swiss-Prot: PLCB_HUMAN, O15120
    Pathway: Phospholipid metabolism; CDP-diacylglycerol biosynthesis; CDP-diacylglycerol from
    sn-glycerol 3-phosphate: step 2/3

     Gene Network CentralTM Interacting Genes and Proteins Network for  AGPAT2 


    5/29 Interacting proteins for AGPAT2 (ENSP000003607613) via UniProtKB, MINT, and/or STRING (see all 29 )

    InteractantInteraction Details
    GeneCardExternal ID(s)
    HNRNPUL2ENSP000003017853STRING (score=.963)
    AGPAT4ENSP000003140363STRING (score=.922)
    GPAMENSP000002652763STRING (score=.91)
    AGKENSP000003475813STRING (score=.899)
    CDS1ENSP000002958873STRING (score=.899)
    About this table

    3 Gene Ontology (GO) biological process terms (links to tree view):

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006654 phosphatidic acid biosynthetic process TAS9212163
    GO:0008152 metabolic process IEA--
    GO:0008654 phospholipid biosynthetic process IEA--
    About this table
    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, Sigma-Aldrich, Tocris Bioscience, and/or Novoseek and Drugs according to Enzo Life Sciences and/or PharmGKB)
    About This Section

    Browse drugs & compounds from Enzo Life Sciences
    Browse Small Molecules at Sigma-Aldrich

    Browse Tocris compounds for AGPAT2
    2 Novoseek chemical compound relationships for AGPAT2 gene
    Compound   Score   Articles   PubMed IDs for Articles with Shared Sentences (# sentences)
    triacylglycerol 44.40 12 16495223 (4), 11967537 (1), 14557833 (1)
    lipid 23.70 5 19278620 (2), 15841084 (1), 18458148 (1)
    About this table


    (GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 219 Homo sapiens; Jun 2 2009) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView,
    non coding RNAs according to RNAdb,
    ESTs according to GeneTide,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from Invitrogen, Millipore, and/or Abnova,
    siRNAs from Applied Biosystems, Sigma-Aldrich,
    shRNA from Sigma-Aldrich, OriGene,
    Tagged/untagged cDNA clones from OriGene,
    Expression Assays from Applied Biosystems)
    About This Section

    Inhib.
    RNA:
    Invitrogen RNAi Products for gene knock-down (AGPAT2)
    Browse for Gene Knock-down Tools from Millipore
    Abnova Chimera RNAi Products for Gene knock-down (AGPAT2)
                   OriGene 29mer shRNA kit in GFP-retroviral vectors (see all 2): NM_001012727

                  Sigma-Aldrich siRNA for AGPAT2  
                         Sigma-Aldrich shRNA for AGPAT2  
                         Explore Sigma-Aldrich super-pooled esiRNAs  

    Applied Biosystems Silencer® siRNAs: 

    NM_001012727  NM_006412  

    REFSEQ mRNAs for AGPAT2 gene (2 alternative transcripts): 

    NM_001012727.1   NM_006412.3   

    Applied Biosystems TaqMan ® Gene Expression Assays: 

    NM_001012727  NM_006412  

                   OriGene GFP tagged cDNA clones in CMV expression vector (see all 2): NM_001012727
                                     Myc/DDK tagged cDNA clones in CMV expression vector (see all 2): NM_001012727
                                     untagged cDNA clones in CMV expression vector (see all 2): NM_001012727 

    Additional cDNA sequence: 

    AF000237.1 AF011374.1 BC000026.2 BC004529.2 BC007269.1 BC019292.1 CR590402.1 CR590462.1 
    CR592360.1 CR597301.1 CR598618.1 CR601358.1 CR602303.1 CR603192.1 CR605868.1 CR611946.1 
    CR615685.1 CR623942.1 CR624126.1 CR625982.1 U56418.2 

    9 DOTS entries:

    DT.92443814  DT.100811410  DT.91859871  DT.92443810  DT.95366130  DT.92443815  DT.100811408  DT.100811411 
    DT.92443809 

    24/378 AceView cDNA sequences (see all 378 ):

    CR597301 BM921501 CR592360 BM767629 BM558647 CR603192 BE731016 BM460130 
    BM470261 BM069745 CR623942 AI611052 BI907617 AA814626 CR590402 AA877363 
    BM817796 BM045722 BI835051 BM914841 CR598618 CA488680 BM930900 BU541108 

    highest scoring ESTs for AGPAT2:

    AF000237 AF011374 AL519660 AL527790 AL556351 AL564457 AW732472 BC000026 BC004529 BC019292 

    Unigene Cluster for AGPAT2:

    1-acylglycerol-3-phosphate O-acyltransferase 2 (lysophosphatidic acid acyltransferase, beta)
    Hs.320151  [show with all ESTs]
    Unigene Representative Sequence: NM_006412


    GeneLoc Exon Structure

    3 Alternative Splicing Database (ASD) splice patterns (SP) for AGPAT2

    ExUns: 1 ^ 2a · 2b ^ 3 ^ 4 ^ 5 ^ 6a · 6b
    SP1:              -                                 
    SP2:              -           -                     
    SP3:                                                

    About this scheme

    ECgene alternative splicing isoforms for AGPAT2

    2 Ensembl transcripts including schematic representations:
    ENST00000371696  ENST00000371694  
    (Experimental results according to 1GeneNote and GNF BioGPS,
    probe sets-to-genes annotations according to 2GeneAnnot , 3GeneTide , Sets of similar genes according to GeneDecks, Electronic Northern calculations according to data from UniGene (Build 219 Homo sapiens), SAGE tags according to CGAP, plus additional links to SOURCE, and/or GNF BioGPS, and/or EXPOLDB, and/or UniProtKB,
    Expression Assays from Applied Biosystems )
    About This Section

    AGPAT2 expression in normal and diseased human tissues

     Applied Biosystems TaqMan ® Gene Expression Assays for AGPAT2

    1 / 2 / 3

    8 probe-sets matching AGPAT2 gene


    Affymetrix
    probe-set
    Array  GeneAnnot data GeneNote data GeneTide data
    # genes Sensitivity Specificity Correlation Length Gb_Accession Consensus Uniqueness Score Rank
    32837_at2, 3 U133-A 1 1.00 1.00 0.86 0.90 U56418 0.80 1.00 0.91 1

    58770_f_at2, 3 U95-C 1 1.00 1.00 0.81 1.23 AI380624 0.40 1.00 0.76 1

    58772_r_at2, 3 U95-C 1 0.88 1.00 0.82 1.23 AI380624 0.40 1.00 0.76 1
    58765_at2, 3 U95-C 1 0.38 1.00 0.82 0.65 AW001559 0.60 1.00 0.82 1
    32837_at2, 3 U133-A 1 1.00 1.00 -- -- U56418 0.80 1.00 0.91 1

    210678_s_at2, 3 U133-A 1 1.00 1.00 -- -- U56418 0.80 1.00 0.91 1
    32837_at2 U133Plus2 1 1.00 1.00 -- -- -- -- -- -- --

    210678_s_at2 U133Plus2 1 1.00 1.00 -- -- -- -- -- -- --
    GeneDecks  AGPAT2 for binary patterns associated with the probe-sets selected above  
    About GeneDecksing
    About this table    
    Data from (Publications) and GNF BioGPS
        About these images
    About these images

    CGAP SAGE TAG: ACCTGGGGAG

    SOURCE GeneReport for Unigene cluster: Hs.320151

    Expression variation in blood from EXPOLDB for AGPAT2

    UniProtKB/Swiss-Prot: PLCB_HUMAN, O15120
    Tissue specificity: Expressed predominantly in heart and liver

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD and/or 5MGI Jun 06 2009, with possible further links to Flybase and/or WormBase, Gene Trees according to Ensembl)
    About This Section


    Orthologs for AGPAT2 gene from 5/14 species (see all 14 )
    Organism Gene Locus Description Human
    Similarity
    NCBI accessions
    dog
    (Canis familiaris)
    AGPAT21   -- 1-acylglycerol-3-phosphate O-acyltransferase 2 (lysophosphatidic more 81.19(n)
    74.69(a)
    491249  XM_548370.2  XP_548370.2 
    chimpanzee
    (Pan troglodytes)
    AGPAT21   -- 1-acylglycerol-3-phosphate O-acyltransferase 2 (lysophosphatidic more 97.6(n)
    96.85(a)
    748669  XM_001162511.1  XP_001162511.1 
    cow
    (Bos taurus)
    AGPAT21   -- 1-acylglycerol-3-phosphate O-acyltransferase 2 (lysophosphatidic more 83.57(n)
    79.86(a)
    512112  XM_589558.3  XP_589558.3 
    rat
    (Rattus norvegicus)
    Agpat21   -- 1-acylglycerol-3-phosphate O-acyltransferase 2 (lysophosphatidic more 79.02(n)
    75.9(a)
    311821  XM_231089.4  XP_231089.4 
    mouse
    (Mus musculus)
    Agpat21, 5 25
    1-acylglycerol-3-phosphate O-acyltransferase 2 (lysophosphatidic more1, 5 80.58(n)1
    76.98(a)1
    675121  NM_026212.11  NP_080488.11 
     AK0024225  AK0108915  (see all 11)
    About this table        Species with no ortholog for AGPAT2

    ENSEMBL Gene Tree for AGPAT2
    (Paralogs according to 1HomoloGene
    and 2Ensembl, Pseudogenes according to 3Pseudogene.org)
    About This Section

    Paralogs for AGPAT2 gene
    ENSG000002043102  

    (According to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, and UniProtKB, Linkage Disequilibrium by HapMap, Genotyping Reagents from Applied Biosystems)
    About This Section


    10/104 NCBI SNPs in AGPAT2 are shown (see all 104 )
    (Click for Applied Biosystems TaqMan ® Genotyping Assay)  (see all 57)
    ABGenomic DataTranscription DataAllele Frequencies
    SNP IDValidChr 9 posSequenceRecsAA
    Chg
    TypeMoreRecsAllele
    freq
    PopTotal
    sample
    More
    ------------
    rs38126121,2
    A,C,F,H138703028(+) TGCTGG/TGCCTC 2 -- ng313Minor allele frequency- T:0.17EU EA 298
    rs38126111,2
    A,C,F,H138702976(+) CGCTTA/GGAGCC 2 -- ng3111Minor allele frequency- G:0.30EA EU WA NA 2518
    rs8789791,2
    A,C,F,H138703299(+) TTTACG/ATGCCA 2 -- ng3110Minor allele frequency- A:0.27NA EA EU WA 742
    rs69511,2
    A,C,F138687583(-) TCAGGG/CTCTCT 2 -- ut31 ese31Minor allele frequency- C:0.06MN 184
    rs38126131,2
    A,C,F138703127(+) GCTGCC/TGGGAG 2 -- ng311Minor allele frequency- T:0.07EA 1494
    rs103201,2
    A,C,F138687508(-) GGAATT/CGGGGC 2 -- ut312Minor allele frequency- C:0.50MN 372
    rs48801191,2
    A,C138687868(+) CTGAGA/GCCAGT 2 -- ut31 ese30--------
    --
    rs70380791,2
    A,C138702160(+) GGGGAC/TGCGCC 2 -- ng310--------
    --
    rs94112631,2
    C138703059(+) GCTGAC/TGGCTG 2 -- ng310--------
    --
    rs23858931,2
    C138701815(+) cccacA/Cacgcc 2 -- ng310--------
    About this table

    HapMap Linkage Disequilibrium images for AGPAT2 (up to first 250kb)

    (in which this Gene is Involved, According to OMIM, UniProtKB, Novoseek, PharmGKB, Genatlas, GeneTests, Blood group antigen gene mutations by BGMUT, HGMD, GAD, HuGE Navigator, BCGD, and/or TGDB.)
    About This Section

    OMIM: 603100   disorders: 608594  

    UniProtKB/Swiss-Prot: PLCB_HUMAN, O15120

  • Defects in AGPAT2 are the cause of congenital generalized lipodystrophy type 1 (CGL1)
    [MIM:608594]; also known as Berardinelli-Seip congenital lipodystrophy type 1 (BSCL1) or
    Berardinelli-Seip syndrome. CGL1 is an autosomal recessive disorder characterized by marked
    paucity of adipose tissue, extreme insulin resistance, hypertriglyceridemia, hepatic steatosis and
    early onset of diabetes
  • 7 Novoseek disease relationships for AGPAT2 gene

    Disease   Score   Articles   PubMed IDs for Articles with Shared Sentences (# sentences)
    lipodystrophy, congenital generalized 97.72 15 11967537 (2), 14557833 (1), 18057387 (1), 14557463 (1) (see all 11)
    lipodystrophy 79.10 6 16409151 (1), 12788894 (1), 16722806 (1), 18698612 (1) (see all 5)
    lipodystrophy, familial partial 75.25 1 14516935 (1)
    insulin resistance 62.69 3 15908053 (1), 19026526 (1), 14516935 (1)
    ovarian cancer 24.62 8 16230405 (2), 15841084 (1), 16944535 (1)
    cancer 0.00 3 14498826 (1), 16488473 (1)
    tumors 0.00 16 16944535 (7), 14578472 (4), 16230405 (1)
    About this table

    GeneTests: AGPAT2
    Berardinelli-Seip Congenital Lipodystrophy

    Human Gene Mutation Database: AGPAT2

    (Possibly Related Articles in Doctor's Guide)
    About This Section

      --

    (in PubMed. Associations of this gene to articles via 1Novoseek, 2HGNC, 3Entrez Gene, 4UniProtKB/Swiss-Prot, 5UniProtKB/TrEMBL, 6GAD, and/or 7PharmGKB)
    About This Section

    10/48 PubMed articles for AGPAT2 gene (see all 48 ):
    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section

     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)
    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, and/or H-InvDB)
    About This Section

    Entrez Gene: 10555 HGNC: 325 AceView: AGPAT2 Ensembl:ENSG00000169692 euGenes: HUgn10555
    ECgene: AGPAT2 H-InvDB: AGPAT2
    (According to HUGE)
    About This Section

      --
    (According to ATLAS, HORDE, IMGT, MTDB, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section

    NameDescription
    GeneReviewshttp://www.genetests.org/query?gene=AGPAT2
    (Available from WIS Yeda, Salk, Tufts)
    About This Section

      --
    (Reagents available from Applied Biosystems, Antibodies and assays by Cell Signaling Technology, Abcam, Novus Biologicals,
    Sigma-Aldrich, R&D Systems, Millipore, Abnova, and/or Invitrogen, Clones available from OriGene,and/or Invitrogen, Drugs and/or compounds by Sigma-Aldrich,
    Enzo Life Sciences, and/or Tocris Bioscience)
    About This Section



    Products for AGPAT2:
     TaqMan ® Gene Expression Assays
     TaqMan ® Genotyping Assays
      Free SNP selection tool



      Invitrogen iPath Pathways  Invitrogen BLOCK-iT™ RNAi
      Invitrogen Antibodies  Invitrogen Assays
      Invitrogen Clones  Invitrogen Q-PCR Products
      Invitrogen Human Recombinant Kinases  Invitrogen Custom Antibody and Peptide Service
      Invitrogen Proteins / Assays / Screening Services  Search Invitrogen catalog for AGPAT2-related products

     Millipore Custom Antibody & Bulk Services
     Millipore Preclinical / Clinical Development Services
     Millipore Immunoassay Services
     Millipore Target Screening & Profiling Services


     Predesigned and custom siRNAs for AGPAT2 Antibodies for AGPAT2
     Explore super-pooled esiRNAs Browse proteins at Sigma-Aldrich
     Lentivirus-delivered shRNAs for AGPAT2 Browse small molecules at Sigma-Aldrich
     "Your Favorite Gene" Pathwaysfeedback


      
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     Recombinant & Natural Proteins  

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     Search for Antibodies & Assays

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     Search OriGene for AGPAT2
     Search Tocris compounds for AGPAT2




     Search www.enzolifesicences.com for proteins, assays, substrates, inhibitors & antibodies
     Antibodies for AGPAT2

    GeneCards Homepage    -    Last full update: 2 Jul 2009        Incremental update: 13 Oct 2009

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