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Aliases for AGPAT1 Gene

Aliases for AGPAT1 Gene

  • 1-Acylglycerol-3-Phosphate O-Acyltransferase 1 2 3 4 5
  • 1-Acylglycerol-3-Phosphate O-Acyltransferase 1 (Lysophosphatidic Acid Acyltransferase, Alpha) 2 3
  • Lysophosphatidic Acid Acyltransferase Alpha 3 4
  • 1-AGP Acyltransferase 1 3 4
  • LPAAT-Alpha 3 4
  • EC 2.3.1.51 4 61
  • 1-AGPAT 1 3 4
  • G15 3 4
  • 1-Acylglycerol-3-Phosphate O-Acyltransferase 1 (Acetoacetly Coenzyme A Thiolase) 3
  • 1-Acyl-Sn-Glycerol-3-Phosphate Acyltransferase Alpha 3
  • Lysophosphatidic Acid Acyltransferase, Alpha 2
  • Lysophospholipid Acyltransferase 3
  • Protein G15 4
  • 1-AGPAT1 3
  • LPAATA 3

External Ids for AGPAT1 Gene

Previous GeneCards Identifiers for AGPAT1 Gene

  • GC06M032163
  • GC06M031906
  • GC06M032207
  • GC06M032243
  • GC06M031890
  • GC06M032135

Summaries for AGPAT1 Gene

Entrez Gene Summary for AGPAT1 Gene

  • This gene encodes an enzyme that converts lysophosphatidic acid (LPA) into phosphatidic acid (PA). LPA and PA are two phospholipids involved in signal transduction and in lipid biosynthesis in cells. This enzyme localizes to the endoplasmic reticulum. This gene is located in the class III region of the human major histocompatibility complex. Alternative splicing results in two transcript variants encoding the same protein. [provided by RefSeq, Jul 2008]

GeneCards Summary for AGPAT1 Gene

AGPAT1 (1-Acylglycerol-3-Phosphate O-Acyltransferase 1) is a Protein Coding gene. Among its related pathways are Metabolism and Acyl chain remodelling of PE. GO annotations related to this gene include transferase activity, transferring acyl groups and 1-acylglycerol-3-phosphate O-acyltransferase activity. An important paralog of this gene is AGPAT2.

UniProtKB/Swiss-Prot for AGPAT1 Gene

  • Converts lysophosphatidic acid (LPA) into phosphatidic acid by incorporating an acyl moiety at the sn-2 position of the glycerol backbone.

Gene Wiki entry for AGPAT1 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for AGPAT1 Gene

Genomics for AGPAT1 Gene

Regulatory Elements for AGPAT1 Gene

Enhancers for AGPAT1 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH06F032165 0.5 ENCODE 14.5 +10.1 10111 4.2 HDGF PKNOX1 ATF1 ARNT CREB3L1 GLIS2 ELK1 GATA2 KDM4B NCOA1 ATF6B RNF5 DXO BRD2 AGPAT1 SKIV2L DDX39B MICB GPSM3 BAG6
GH06F032175 1.1 ENCODE 13.8 +0.4 352 5.1 HDGF PKNOX1 ARNT WRNIP1 ARID4B SIN3A DMAP1 YBX1 ZNF2 YY1 LY6G5B DDX39B PPT2 LSM2 BRD2 HLA-DRB1 EHMT2 RNF5 ATF6B EGFL8
GH06F032118 0.5 ENCODE 11.7 +58.9 58919 1.5 PKNOX1 ATF1 ARNT CREB3L1 WRNIP1 ARID4B SIN3A DMAP1 ZNF48 SLC30A9 PPT2 PRRT1 EGFL8 MIR6721 RNF5 AGPAT1 SKIV2L TNXB ATF6B
GH06F032075 0.8 Ensembl ENCODE 11.4 +101.6 101649 1.8 ZNF639 ZNF362 ZNF280D HLF NFRKB CEBPB ZFP37 ZKSCAN1 PATZ1 GLIS1 TNXB ATF6B FKBPL PPT2 PRRT1 EGFL8 AGPAT1 MIR6721 RNF5 RNA5SP206
GH06F032243 0.8 Ensembl ENCODE 11 -66.6 -66597 1.4 ZNF493 ARID4B ZNF48 ZNF2 ZNF121 GLIS2 ZNF143 KLF7 ZNF202 NCOA1 LY6G5B BRD2 ATF6B PPT2 DDX39B LSM2 NFKBIL1 EGFL8 RXRB HLA-DRB1
- Elite enhancer/Elite enhancer-gene association Download Table
Download GeneHancer data dump

Enhancers around AGPAT1 on UCSC Golden Path with GeneCards custom track

Promoters for AGPAT1 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000662357 811 4201 HDGF PKNOX1 ARNT WRNIP1 ARID4B SIN3A DMAP1 YBX1 ZNF2 YY1

Genomic Location for AGPAT1 Gene

Chromosome:
6
Start:
32,168,206 bp from pter
End:
32,178,111 bp from pter
Size:
9,906 bases
Orientation:
Minus strand

Genomic View for AGPAT1 Gene

Genes around AGPAT1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
AGPAT1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for AGPAT1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

Proteins for AGPAT1 Gene

  • Protein details for AGPAT1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q99943-PLCA_HUMAN
    Recommended name:
    1-acyl-sn-glycerol-3-phosphate acyltransferase alpha
    Protein Accession:
    Q99943
    Secondary Accessions:
    • A2BFI5
    • Q5BL03

    Protein attributes for AGPAT1 Gene

    Size:
    283 amino acids
    Molecular mass:
    31717 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=AAB47493.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305};

neXtProt entry for AGPAT1 Gene

Post-translational modifications for AGPAT1 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Domains & Families for AGPAT1 Gene

Gene Families for AGPAT1 Gene

Protein Domains for AGPAT1 Gene

Suggested Antigen Peptide Sequences for AGPAT1 Gene

Graphical View of Domain Structure for InterPro Entry

Q99943

UniProtKB/Swiss-Prot:

PLCA_HUMAN :
  • The HXXXXD motif is essential for acyltransferase activity and may constitute the binding site for the phosphate moiety of the glycerol-3-phosphate.
  • Belongs to the 1-acyl-sn-glycerol-3-phosphate acyltransferase family.
Domain:
  • The HXXXXD motif is essential for acyltransferase activity and may constitute the binding site for the phosphate moiety of the glycerol-3-phosphate.
Family:
  • Belongs to the 1-acyl-sn-glycerol-3-phosphate acyltransferase family.
genes like me logo Genes that share domains with AGPAT1: view

Function for AGPAT1 Gene

Molecular function for AGPAT1 Gene

GENATLAS Biochemistry:
lysophosphatidic acid acyltransferase alpha,expressed in many tissues with highest expression in skeletal muscle,localized in endoplasmic reticulum
UniProtKB/Swiss-Prot CatalyticActivity:
Acyl-CoA + 1-acyl-sn-glycerol 3-phosphate = CoA + 1,2-diacyl-sn-glycerol 3-phosphate.
UniProtKB/Swiss-Prot Function:
Converts lysophosphatidic acid (LPA) into phosphatidic acid by incorporating an acyl moiety at the sn-2 position of the glycerol backbone.

Enzyme Numbers (IUBMB) for AGPAT1 Gene

Gene Ontology (GO) - Molecular Function for AGPAT1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003841 1-acylglycerol-3-phosphate O-acyltransferase activity TAS --
GO:0005515 protein binding IPI 25416956
GO:0016740 transferase activity IEA --
GO:0016746 transferase activity, transferring acyl groups IEA --
genes like me logo Genes that share ontologies with AGPAT1: view
genes like me logo Genes that share phenotypes with AGPAT1: view

Animal Models for AGPAT1 Gene

MGI Knock Outs for AGPAT1:

Animal Model Products

  • Taconic Biosciences Mouse Models for AGPAT1

Inhibitory RNA Products

Flow Cytometry Products

No data available for Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for AGPAT1 Gene

Localization for AGPAT1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for AGPAT1 Gene

Endoplasmic reticulum membrane; Multi-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for AGPAT1 Gene COMPARTMENTS Subcellular localization image for AGPAT1 gene
Compartment Confidence
endoplasmic reticulum 2
plasma membrane 2
extracellular 1

Gene Ontology (GO) - Cellular Components for AGPAT1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005783 endoplasmic reticulum TAS 9461603
GO:0005789 endoplasmic reticulum membrane TAS --
GO:0016020 membrane IDA 19946888
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with AGPAT1: view

Pathways & Interactions for AGPAT1 Gene

genes like me logo Genes that share pathways with AGPAT1: view

UniProtKB/Swiss-Prot Q99943-PLCA_HUMAN

  • Pathway: Phospholipid metabolism; CDP-diacylglycerol biosynthesis; CDP-diacylglycerol from sn-glycerol 3-phosphate: step 2/3.

Gene Ontology (GO) - Biological Process for AGPAT1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001819 positive regulation of cytokine production IMP 9212163
GO:0001961 positive regulation of cytokine-mediated signaling pathway IC 9212163
GO:0006629 lipid metabolic process IEA --
GO:0006644 phospholipid metabolic process TAS 9212163
GO:0006654 phosphatidic acid biosynthetic process TAS --
genes like me logo Genes that share ontologies with AGPAT1: view

No data available for SIGNOR curated interactions for AGPAT1 Gene

Drugs & Compounds for AGPAT1 Gene

(3) Drugs for AGPAT1 Gene - From: HMDB and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Propionyl-CoA Experimental Pharma 0
Coenzyme A Nutra 0

(58) Additional Compounds for AGPAT1 Gene - From: HMDB and Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
(2E)-Decenoyl-CoA
  • (E)-S-2-decenoate
  • (E)-S-2-decenoate CoA
  • (E)-S-2-decenoate Coenzyme A
  • (E)-S-2-decenoic acid
  • 2-trans-Decenoyl-CoA
10018-95-8
(2E)-Dodecenoyl-CoA
  • (2E)-Dodec-2-enoyl-CoA
  • (2E)-Dodec-2-enoyl-Coenzyme A
  • 2-trans-Dodecenoyl-CoA
  • 2-trans-Dodecenoyl-Coenzyme A
1066-12-2
(2E)-Hexadecenoyl-CoA
  • (2E)-Hexadecenoyl-CoA
  • (2E)-Hexadecenoyl-Coenzyme A
  • trans-2-Hexadecenoyl-CoA
  • trans-2-Hexadecenoyl-Coenzyme A
4460-95-1
(2E)-Octenoyl-CoA
  • (E)-S-2-octenoate
  • (E)-S-2-octenoate CoA
  • (E)-S-2-octenoate Coenzyme A
  • (E)-S-2-octenoic acid
  • 2,3-trans-Octenoyl coenzyme A
10018-94-7
(2E)-Tetradecenoyl-CoA
  • (2E)-Tetradecenoyl-CoA
  • (2E)-Tetradecenoyl-Coenzyme A
  • Trans-tetra-dec-2-enoyl-CoA
  • Trans-tetra-dec-2-enoyl-CoA.
  • Trans-tetra-dec-2-enoyl-Coenzyme A
38795-33-4
genes like me logo Genes that share compounds with AGPAT1: view

Transcripts for AGPAT1 Gene

Unigene Clusters for AGPAT1 Gene

1-acylglycerol-3-phosphate O-acyltransferase 1:
Representative Sequences:

Inhibitory RNA Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for AGPAT1 Gene

No ASD Table

Relevant External Links for AGPAT1 Gene

GeneLoc Exon Structure for
AGPAT1
ECgene alternative splicing isoforms for
AGPAT1

Expression for AGPAT1 Gene

mRNA expression in normal human tissues for AGPAT1 Gene

Protein differential expression in normal tissues from HIPED for AGPAT1 Gene

This gene is overexpressed in Bone (40.3).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for AGPAT1 Gene



Protein tissue co-expression partners for AGPAT1 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of AGPAT1 Gene:

AGPAT1

SOURCE GeneReport for Unigene cluster for AGPAT1 Gene:

Hs.409230

mRNA Expression by UniProt/SwissProt for AGPAT1 Gene:

Q99943-PLCA_HUMAN
Tissue specificity: Widely expressed. Expressed in adipose tissue and at high levels in testis and pancreas. Expressed at lower levels in tissues such as heart, brain, placenta, kidney, lung, spleen, thymus, prostate, ovary, intestine, colon, leukocyte and liver.
genes like me logo Genes that share expression patterns with AGPAT1: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and mRNA differential expression in normal tissues for AGPAT1 Gene

Orthologs for AGPAT1 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for AGPAT1 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia AGPAT1 34 35
  • 99.88 (n)
cow
(Bos Taurus)
Mammalia AGPAT1 34 35
  • 93.4 (n)
dog
(Canis familiaris)
Mammalia AGPAT1 34 35
  • 93.4 (n)
oppossum
(Monodelphis domestica)
Mammalia AGPAT1 35
  • 92 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Agpat1 34
  • 89.64 (n)
mouse
(Mus musculus)
Mammalia Agpat1 34 16 35
  • 89.17 (n)
platypus
(Ornithorhynchus anatinus)
Mammalia AGPAT1 35
  • 71 (a)
OneToOne
chicken
(Gallus gallus)
Aves -- 35
  • 53 (a)
ManyToMany
-- 35
  • 47 (a)
ManyToMany
lizard
(Anolis carolinensis)
Reptilia AGPAT1 35
  • 61 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia agpat1 34
  • 65.75 (n)
Str.17787 34
African clawed frog
(Xenopus laevis)
Amphibia Xl.15198 34
zebrafish
(Danio rerio)
Actinopterygii agpat2 34
  • 58.06 (n)
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP002021 34
  • 51.22 (n)
fruit fly
(Drosophila melanogaster)
Insecta CG3812 36 34 35
  • 50 (n)
fu12 36 35
  • 33 (a)
worm
(Caenorhabditis elegans)
Secernentea acl-2 34 35
  • 48.6 (n)
T06E8.1 36
  • 41 (a)
acl-1 35
  • 28 (a)
ManyToMany
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes SLC1 35 37 37
  • 25 (a)
OneToMany
Species where no ortholog for AGPAT1 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for AGPAT1 Gene

ENSEMBL:
Gene Tree for AGPAT1 (if available)
TreeFam:
Gene Tree for AGPAT1 (if available)

Paralogs for AGPAT1 Gene

Paralogs for AGPAT1 Gene

(1) SIMAP similar genes for AGPAT1 Gene using alignment to 2 proteins:

genes like me logo Genes that share paralogs with AGPAT1: view

Variants for AGPAT1 Gene

Sequence variations from dbSNP and Humsavar for AGPAT1 Gene

SNP ID Clin Chr 06 pos Sequence Context AA Info Type
rs1061807 -- 32,169,061(-) GCAGT(C/T)TCCAC utr-variant-3-prime
rs1061808 -- 32,168,770(-) TCATC(A/C)TGGGA intron-variant, downstream-variant-500B, utr-variant-3-prime
rs1061840 -- 32,168,492(-) CACTT(C/T)TGCCC intron-variant, downstream-variant-500B, utr-variant-3-prime
rs1061877 -- 32,168,378(-) CATTT(C/T)TTCCT intron-variant, downstream-variant-500B, utr-variant-3-prime
rs1061923 -- 32,168,328(-) TTCCC(A/C)CAACT intron-variant, downstream-variant-500B, utr-variant-3-prime

Structural Variations from Database of Genomic Variants (DGV) for AGPAT1 Gene

Variant ID Type Subtype PubMed ID
dgv10404n54 CNV loss 21841781
dgv10463n54 CNV loss 21841781
dgv10472n54 CNV loss 21841781
esv24778 CNV loss 19812545
esv2759415 CNV gain+loss 17122850
nsv1073969 CNV deletion 25765185
nsv1112900 CNV deletion 24896259
nsv1126749 CNV deletion 24896259
nsv602104 CNV loss 21841781
nsv830629 CNV loss 17160897

Variation tolerance for AGPAT1 Gene

Residual Variation Intolerance Score: 44% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.65; 13.99% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for AGPAT1 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
AGPAT1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for AGPAT1 Gene

Disorders for AGPAT1 Gene

Relevant External Links for AGPAT1

Genetic Association Database (GAD)
AGPAT1
Human Genome Epidemiology (HuGE) Navigator
AGPAT1
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
AGPAT1

No disorders were found for AGPAT1 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for AGPAT1 Gene

Publications for AGPAT1 Gene

  1. Characterization of a human lysophosphatidic acid acyltransferase that is encoded by a gene located in the class III region of the human major histocompatibility complex. (PMID: 9461603) Aguado B. … Campbell R.D. (J. Biol. Chem. 1998) 2 3 4 22 64
  2. Cloning and expression of two human lysophosphatidic acid acyltransferase cDNAs that enhance cytokine-induced signaling responses in cells. (PMID: 9212163) West J. … Leung D.W. (DNA Cell Biol. 1997) 3 4 22 64
  3. A human cDNA sequence with homology to non-mammalian lysophosphatidic acid acyltransferases. (PMID: 9291118) Stamps A.C. … Finnen M.J. (Biochem. J. 1997) 2 3 4 64
  4. Genome-wide association study identifies novel loci associated with circulating phospho- and sphingolipid concentrations. (PMID: 22359512) Demirkan A. … Schmitz G. (PLoS Genet. 2012) 3 46 64
  5. Association of MHC SNP genotype with susceptibility to type 1 diabetes: a modified survival approach. (PMID: 19143821) McKinnon E. … James I. (Diabetes Obes Metab 2009) 3 46 64

Products for AGPAT1 Gene

Sources for AGPAT1 Gene

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