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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

AGPAT1 Gene

protein-coding   GIFtS: 57
GCID: GC06M032135

1-acylglycerol-3-phosphate O-acyltransferase 1

(Previous names: 1-acylglycerol-3-phosphate O-acyltransferase 1 (lysophosphatidic...)
 Explore 9 diseases affiliated with
AGPAT1 via
MalaCards
our new
 Human Malady Compendium 
Biological research products
for AGPAT1    

Aliases
for AGPAT1 gene

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, and/or 10fRNAdb)
About This Section
Aliases
1-Acylglycerol-3-Phosphate O-Acyltransferase 11 2 3     EC 2.3.1.513 8
LPAAT-Alpha1     LPAATA2 5
1-Acylglycerol-3-Phosphate O-Acyltransferase 1 (Lysophosphatidic Acid
Acyltransferase, Alpha)1 2
     1-AGPAT12
Lysophosphatidic Acid Acyltransferase Alpha2 3     1-Acyl-Sn-Glycerol-3-Phosphate Acyltransferase Alpha2
1-AGP Acyltransferase 12 3     1-Acylglycerol-3-Phosphate O-Acyltransferase 1 (Acetoacetly Coenzyme A
Thiolase)2
1-AGPAT 12 3     Lysophospholipid Acyltransferase2
G152 3     Protein G153

External Ids:    HGNC: 3241   Entrez Gene: 105542   Ensembl: ENSG000002043107   OMIM: 6030995   UniProtKB: Q999433   

Export aliases for AGPAT1 gene to outside databases

Previous GC identifers: GC06M032163 GC06M031906 GC06M032207 GC06M032243 GC06M031890


Summaries
for AGPAT1 gene

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section
Entrez Gene summary for AGPAT1:
This gene encodes an enzyme that converts lysophosphatidic acid (LPA) into phosphatidic acid (PA). LPA and PA are two
phospholipids involved in signal transduction and in lipid biosynthesis in cells. This enzyme localizes to the
endoplasmic reticulum. This gene is located in the class III region of the human major histocompatibility complex.
Alternative splicing results in two transcript variants encoding the same protein. (provided by RefSeq, Jul 2008)

UniProtKB/Swiss-Prot: PLCA_HUMAN, Q99943
Function: Converts lysophosphatidic acid (LPA) into phosphatidic acid by incorporating an acyl moiety at the sn-2
position of the glycerol backbone

Gene Wiki entry for AGPAT1


Genomic Views
for AGPAT1 gene

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000006.11  NC_018917.1  NT_007592.15  NT_113891.2  NT_167244.1  NT_167246.1  NT_167247.1  NT_167248.1  
NT_167249.1  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the AGPAT1 gene promoter:
         E2F-3a   E2F-4   HEN1   E2F-5   STAT3   E47   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmids (see all 2): AGPAT1 promoter sequence
   Search SABiosciences Chromatin IP Primers for AGPAT1

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat AGPAT1


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 6p21.3   Ensembl cytogenetic band:  6p21.32   HGNC cytogenetic band: 6p21.3

AGPAT1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
AGPAT1 gene location

GeneLoc information about chromosome 6         GeneLoc Exon Structure

GeneLoc location for GC06M032135:  view genomic region     (about GC identifiers)

Start:
 32,135,983 bp from pter      End:
 32,145,888 bp from pter
Size:
 9,906 bases      Orientation:
 minus strand

6 alternative locations:
Chr6-,ALT_REF_LOCI_4 32,098,466-32,108,371      Chr6-,ALT_REF_LOCI_5 32,127,235-32,137,140      Chr6-,ALT_REF_LOCI_6 32,093,612-32,139,092     
Chr6-,ALT_REF_LOCI_2 32,084,466-32,133,553      Chr6-,ALT_REF_LOCI_1 32,147,333-32,165,532      Chr6-,ALT_REF_LOCI_7 32,073,176-32,083,081     

Proteins
for AGPAT1 gene

(According to 1UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to 2PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section
UniProtKB/Swiss-Prot: PLCA_HUMAN, Q99943 (See protein sequence)
Recommended Name: 1-acyl-sn-glycerol-3-phosphate acyltransferase alpha  
Size: 283 amino acids; 31717 Da
Subcellular location: Membrane; Multi-pass membrane protein (Potential)
Sequence caution: Sequence=AAB47493.1; Type=Erroneous initiation;
Secondary accessions: A2BFI5 Q5BL03

Explore the universe of human proteins at neXtProt for AGPAT1: NX_Q99943

Post-translational modifications:

  • View modification sites using PhosphoSitePlus2
  • View neXtProt modification sites for NX_Q99943

    • 4/7 DME Specific Peptides for AGPAT1 (Q99943) (see all 7)
     VRHSMLT  NHQSSLD  PIVMSSYQDFY  KYLYGIRVEVRGAHHFPP 

    AGPAT1 Protein expression data from MOPED and PaxDb:    About this image 
    Estimated protein expression log10 (pmol).

    REFSEQ proteins (2 alternative transcripts): 
    NP_006402.1  NP_116130.2  

    ENSEMBL proteins: 
     ENSP00000378874   ENSP00000364248   ENSP00000378877   ENSP00000364245   ENSP00000378875  
     ENSP00000337463   ENSP00000410473  
    Reactome Protein details: Q99943
    Human Recombinant Protein Products: 
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    Novus Biologicals AGPAT1 Protein
    Novus Biologicals AGPAT1 Lysates
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    Uscn Proteins for AGPAT1

    Gene Ontology (GO): 3 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005783endoplasmic reticulum TAS9461603
    GO:0005789endoplasmic reticulum membrane TAS--
    GO:0016021integral to membrane IEA--


    AGPAT1 for ontologies           About GeneDecksing



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    Uscn ELISAs and CLIAs for AGPAT1

    Protein Domains /
    Families
    for AGPAT1 gene

    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    AGPAT1 for domains           About GeneDecksing

    2 InterPro domains/families:
     IPR002123 Plipid/glycerol_acylTrfase
     IPR004552 AGP_acyltrans

    Graphical View of Domain Structure for InterPro Entry Q99943

    ProtoNet protein and cluster: Q99943

    1 Blocks protein family: IPB002123 Phospholipid/glycerol acyltransferase

    UniProtKB/Swiss-Prot: PLCA_HUMAN, Q99943
    Domain: The HXXXXD motif is essential for acyltransferase activity and may constitute the binding site for the
    phosphate moiety of the glycerol-3-phosphate (By similarity)
    Similarity: Belongs to the 1-acyl-sn-glycerol-3-phosphate acyltransferase family


    Function
    for AGPAT1 gene

    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
    About This Section
    Function Summary:

         UniProtKB/Swiss-Prot: PLCA_HUMAN, Q99943
    Function: Converts lysophosphatidic acid (LPA) into phosphatidic acid by incorporating an acyl moiety at the sn-2
    position of the glycerol backbone
    Catalytic activity: Acyl-CoA + 1-acyl-sn-glycerol 3-phosphate = CoA + 1,2-diacyl-sn-glycerol 3-phosphate

         Genatlas biochemistry entry for AGPAT1:
    lysophosphatidic acid acyltransferase alpha,expressed in many tissues with highest expression in skeletal
    muscle,localized in endoplasmic reticulum

    Enzyme Number (IUBMB): EC 2.3.1.511 2

    miRNA
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    hsa-miR-548am hsa-miR-548d-3p hsa-miR-769-5p hsa-miR-3065-3p hsa-miR-4290 hsa-miR-548aa hsa-miR-1205 hsa-miR-1291
    SwitchGear 3'UTR luciferase reporter plasmid: AGPAT1 3' UTR sequence
    Inhib. RNA
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    OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for AGPAT1 (see all 7)
    OriGene shRNA RFP: AGPAT1
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    Gene Editing
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    Clone
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    In Situ Assay
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    Gene Ontology (GO): 1 molecular function term (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:00038411-acylglycerol-3-phosphate O-acyltransferase activity IGI9212163


    AGPAT1 for ontologies           About GeneDecksing



    Pathways & Interactions
    for AGPAT1 gene

    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
    About This Section

    Unified GeneCards pathways - 5/11 super-pathways (see all 11) About this table 
    See pathways by source

    Super-pathwaycontained gene-specific pathways
    1CDP-diacylglycerol biosynthesis I
    		CDP-diacylglycerol biosynthesis I1.00
    		triacylglycerol biosynthesis0.50
    		phosphatidylglycerol biosynthesis II (non-plastidic)0.94
    		Triacylglyceride Synthesis0.17
    2Glycerophospholipid biosynthesis
    		Glycerophospholipid biosynthesis1.00
    		Glycerophospholipid metabolism0.54
    		Phospholipid metabolism0.64
    3Metabolism
    		Metabolism1.00
    		Metabolism of lipids and lipoproteins0.34
    		Metabolic pathways0.38
    4Transcriptional activation of GP-acyl transferase gene by ChREBP:MLX
    		Transcriptional activation of GP-acyl transferase gene by ChREBP:MLX1.00
    5Glycerolipid metabolism
    		Glycerolipid metabolism1.00

    Pathway sources
    See GeneCards unified pathways
    Show all pathways


    4 BioSystems Pathways for AGPAT1 
        CDP-diacylglycerol biosynthesis I
    Triacylglyceride Synthesis
    triacylglycerol biosynthesis
    phosphatidylglycerol biosynthesis II (non-plastidic)

    5/10        Reactome Pathways for AGPAT1 (see all 10)
        Synthesis of PA
    Transcriptional activation of GP-acyl transferase gene by ChREBP:MLX
    Metabolism
    Phospholipid metabolism
    Triglyceride Biosynthesis


    4         Kegg Pathways  (Kegg details for AGPAT1):
        Glycerolipid metabolism
    Glycerophospholipid metabolism
    Metabolic pathways
    Fat digestion and absorption

    UniProtKB/Swiss-Prot: PLCA_HUMAN, Q99943
    Pathway: Phospholipid metabolism; CDP-diacylglycerol biosynthesis; CDP-diacylglycerol from sn-glycerol 3-phosphate:
    step 2/3


    AGPAT1 for pathways           About GeneDecksing

    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for AGPAT1

    5/45 Interacting proteins for AGPAT1 (Q999433) via UniProtKB, MINT, STRING, and/or I2D (see all 45)

    InteractantInteraction Details
    GeneCardExternal ID(s)
    CYP51A1Q168503I2D: score=4 
    DHDDSQ86SQ93I2D: score=4 
    LSSP484493I2D: score=4 
    SLC27A2O149753I2D: score=4 
    ABCF3Q9NUQ83I2D: score=3 
    About this table

    Gene Ontology (GO): 5/11 biological process terms (GO ID links to tree view) (see all 11):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0001819positive regulation of cytokine production IMP9212163
    GO:0001961positive regulation of cytokine-mediated signaling pathway IC9212163
    GO:0006112energy reserve metabolic process TAS--
    GO:0006644phospholipid metabolic process TAS--
    GO:0006654phosphatidic acid biosynthetic process TAS--


    AGPAT1 for ontologies           About GeneDecksing



    Drugs & Compounds
    for AGPAT1 gene

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section

    AGPAT1 for compounds           About GeneDecksing

    Browse Small Molecules at EMD Millipore
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    Browse Tocris compounds for AGPAT1

    10/55 HMDB Compounds for AGPAT1 (see all 55)    About this table
    CompoundSynonyms CAS #PubMed Ids
    (2E)-Decenoyl-CoA(E)-S-2-decenoate Coenzyme A (see all 15)10018-95-8--
    (2E)-Dodecenoyl-CoA2-trans-Dodecenoyl-Coenzyme A (see all 4)1066-12-2--
    (2E)-Hexadecenoyl-CoAtrans-2-Hexadecenoyl-CoA (see all 4)4460-95-1--
    (2E)-Octenoyl-CoA(E)-S-2-octenoate Coenzyme A (see all 16)10018-94-7--
    (2E)-Tetradecenoyl-CoA(2E)-Tetradecenoyl-Coenzyme A (see all 8)38795-33-4--
    2-Methylbutyryl-CoA2-methylbutanoyl-CoA (see all 11)6712-02-3--
    2-Methylhexanoyl-CoA2-Methylhexanoyl-CoEnzyme A (see all 5)----
    3Z-dodecenoyl-CoAS-[2-[3-[[(2R)-4-[[[(2R,3R,5R)-5-(6-aminopurin-9-yl)-4-hydroxy-3-phosphonooxyoxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-hydroxyphosphoryl]oxy-2-hydroxy-3,3-dimethylbutanoyl]amino]propanoylamino]ethyl] (Z)-dodec-3-enethioate (see all 4)2152-91-2--
    Acetyl-CoAS-Acetyl coenzyme A (see all 13)72-89-9--
    Acrylyl-CoAAcryloyl coenzyme A (see all 14)5776-58-9--
    6 Novoseek chemical compound relationships for AGPAT1 gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    lysophospholipid 96.6 48 2105213 (9), 20238429 (3), 18538854 (3), 15972316 (3) (see all 27)
    arachidonic acid 69.1 8 2105213 (2), 9250613 (1), 10793640 (1), 18772128 (1) (see all 6)
    acyl-coa 68.4 11 8547334 (2), 9610838 (2), 18156367 (1), 9182714 (1) (see all 6)
    phospholipid 63.1 6 9453575 (1), 9250613 (1), 7702576 (1), 18403647 (1)
    phosphatidylcholine 45.3 1 11243703 (1)
    fatty acid 34.4 1 9250613 (1)

    Search CenterWatch for drugs/clinical trials and news about AGPAT1 / PLCA 

    Transcripts
    for AGPAT1 gene

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section
    REFSEQ mRNAs for AGPAT1 gene (2 alternative transcripts): 
    NM_006411.3  NM_032741.4  

    Unigene Cluster for AGPAT1:

    1-acylglycerol-3-phosphate O-acyltransferase 1 (lysophosphatidic acid acyltransferase, alpha)
    Hs.409230  [show with all ESTs]
    Unigene Representative Sequence: AK056346
    9 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000395496 ENST00000375107(uc003oae.3 uc011dpk.2 uc003oai.1 uc011dpl.2)
    ENST00000395499 ENST00000375104 ENST00000490711(uc003oag.3) ENST00000395497
    ENST00000336984(uc003oah.3) ENST00000476663 ENST00000412465

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    SwitchGear 3'UTR luciferase reporter plasmid: AGPAT1 3' UTR sequence
    Inhib. RNA
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    Clone
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    Primer
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    Additional cDNA sequence: 

    AF007145.1 AK056346.1 AK058025.1 AK129818.1 AK299252.1 AK315950.1 BC002402.2 BC003007.1 
    BC004310.1 BC006818.1 BC090849.1 U56417.1 U75971.1 Y09565.1 

    24/28 DOTS entries (see all 28):

    DT.97802534  DT.100045133  DT.121378221  DT.86840553  DT.100844873  DT.121378245  DT.95267539  DT.121378455 
    DT.91831976  DT.448281  DT.100705504  DT.454641  DT.121378279  DT.121378323  DT.95267517  DT.95267521 
    DT.100807740  DT.100852579  DT.121378294  DT.100045129  DT.121378254  DT.121378313  DT.121378397  DT.92399762 

    24/364 AceView cDNA sequences (see all 364):

    BQ680155 BQ687349 BM546760 AI208159 BQ690149 BQ688170 BC003007 BM041253 
    BC004310 AI911891 CA430936 AA603976 BU944038 BQ058976 BQ688445 BQ017324 
    Y09565 CA454947 BM905718 BE733108 NM_006411 AA604276 AI128547 BX506195 

    GeneLoc Exon Structure


    Expression
    for AGPAT1 gene

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    AGPAT1 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS
    CGAP TAG: ACCCCACCCA

    Microarray
    RNAseq (Illumina Body Map)
    (100×FPKM)½
    SAGE (Serial Analysis of Gene Expression)
    About this image
    See AGPAT1 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for AGPAT1

    SOURCE GeneReport for Unigene cluster: Hs.409230
        SABiosciences Custom PCR Arrays for AGPAT1
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    In Situ
    Assay Products:     
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    Orthologs
    for AGPAT1 gene

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section
    This gene was present in the last universal common ancestor (LUCA).

    Orthologs for AGPAT1 gene from 9/29 species (see all 29)    About this table
    Organism Taxonomic
    classification    		 Gene Description Human
    Similarity    		 Orthology
    Type    		 Details
    chicken
    (Gallus gallus)    		 Aves AGPAT11 1-acylglycerol-3-phosphate O-acyltransferase 1 (lysophosphatidic more 62.99(n)
    57.87(a)    		   419941  XM_418063.2  XP_418063.2 
    lizard
    (Anolis carolinensis)    		 Reptilia --
    --
    (see all 3)    		 --
    		 59(a)
    52(a)
    (see all 3)    		 1 ↔ 1
    possible ortholog
    (see all 3)    		 2(198698983-198719602)
    6(71689481-71705555)
    African clawed frog
    (Xenopus laevis)    		 Amphibia Xl.151982 Xenopus laevis transcribed sequence with moderate similarity more 73.54(n)    BJ035411.1 
    zebrafish
    (Danio rerio)    		 Actinopterygii agpat21 1-acylglycerol-3-phosphate O-acyltransferase 2 (lysophosphatidic more 58.76(n)
    54.55(a)    		   777624  NM_001077732.1  NP_001071200.1 
    fruit fly
    (Drosophila melanogaster)    		 Insecta CG38121 , 3 1-acylglycerol-3-phosphate
    O-acyltransferase3
    CG38121    		 41(a)
    (best of 2)3
    50.37(n)1
    41.42(a)1    		   322301  NM_132600.11  NP_572828.11 
    worm
    (Caenorhabditis elegans)    		 Secernentea T06E8.13
    acl-21    		 1-acyl-SN-glycerol-3-phophate
    acyltransferase3
    Protein ACL-21    		 41(a)3
    46.22(n)1
    37.11(a)1    		   V(10030899-10033686)3
    1793981  NM_073177.31  NP_505578.11 
    thale cress
    (Arabidopsis thaliana)    		 eudicotyledons EMB19956
    		 1-acyl-sn-glycerol-3-phosphate acyltransferase 1
    		 13(a)
    		 1 → many
    		 4(14932334-14934528)
    rice
    (Oryza sativa)    		 Liliopsida --
    --
    		 acyltransferase, putative, expressed
    		 20(a)
    14(a)
    		 many ↔ many
    many ↔ many
    		 4(31601482-31603139)
    10(18845603-18848911)
    E. coli
    (Escherichia coli)    		 Gamma proteobacteria plsC6
    		 1-acyl-sn-glycerol-3-phosphate acyltransferase
    		 28(a)
    		 1 → many
    		 Chromosome(3160766-3161503)


    ENSEMBL Gene Tree for AGPAT1 (if available)
    TreeFam Gene Tree for AGPAT1 (if available) 

    Paralogs
    for AGPAT1 gene

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for AGPAT1 gene
    AGPAT22  
    1 SIMAP similar gene for AGPAT1 using alignment to 3 protein entries:     PLCA_HUMAN (see all proteins):
    AGPAT2

    AGPAT1 for paralogs           About GeneDecksing



    Genomic Variants
    for AGPAT1 gene

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/103 NCBI SNPs in AGPAT1 are shown (see all 103)     About this table
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance    		Chr 6 posSequence#AA
    Chg    		TypeMore#Allele
    freq    		PopTotal
    sample    		More
    ----------
    rs2050001,2
    		C,F,A,H,--32135878(-) TCCCCC/GTTTCT 5 -- ds5001 ut31 nc-transcript-variant12Minor allele frequency- G:0.06NS EA NA CSA WA 974
    rs717503321,2
    		C,--32135948(+) AACTG-/CTTCTTCA 5 -- nc-transcript-variantut31 ds50010--------
    rs2019305951,2
    		--32136011(+) TTCAG-/TTTTTT 5 -- ut31 nc-transcript-variant0--------
    rs18020361,2
    		C,--32136029(+) TATCCA/G/TGATAA 10 -- ut31 nc-transcript-variant2CSA NA 121
    rs1475037451,2
    		--32136052(+) AACCAC/GGCAAA 5 -- ut31 nc-transcript-variant0--------
    rs1925213471,2
    		--32136203(+) AGAAAG/TAAATT 5 -- ut31 ds5001 int10--------
    rs10618401,2
    		C--32136269(-) CACTTC/TTGCCC 5 -- ut31 int1 ds5001 ese30--------
    rs10618081,2
    		C,F,A,H,--32136547(-) TCATCC/ATGGGA 5 -- ut31 ds5001 int135Minor allele frequency- A:0.44EA NS MN NA WA CSA 4982
    rs1394270261,2
    		--32136593(+) AGGGCA/GAGAAG 2 -- ut310--------
    rs115534301,2
    		C,F,H,--32136771(-) CCAGTG/AACTCA 2 -- ut315Minor allele frequency- A:0.02NS NA 720

    HapMap Linkage Disequilibrium report for AGPAT1 (32135983 - 32145888 bp)
    Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
    Database of Genomic Variants (DGV): 4 variations for AGPAT1
         4 CNVs: 3602 64475 93635 93634

    SABiosciences Cancer Mutation PCR Assays
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    DNA2.0 Custom Variant and Variant Library Synthesis for AGPAT1

    Disorders / Diseases
    for AGPAT1 gene

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    AGPAT1 for disorders           About GeneDecksing

    OMIM gene information: 603099    OMIM disorders: --

    9 diseases for AGPAT1:    About MalaCards
    systemic lupus erythematosus    lupus erythematosus    aspergillosis    lipodystrophy
    alzheimer's disease    cholesterol    tuberculosis    mycobacterium tuberculosis
    sepsis

    1 Novoseek disease relationship for AGPAT1 gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    inflammation 0 2 12965115 (1), 18538854 (1)

    Human Genome Epidemiology (HuGE) Navigator: AGPAT1 (4 documents)

    Export disorders for AGPAT1 gene to outside databases

    Publications
    for AGPAT1 gene

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for AGPAT1 gene, integrated from 9 sources (see all 57):
    (articles sorted by number of sources associating them with AGPAT1)    		    Utopia: connect your pdf to the dynamic
    world of online information

    1. Characterization of a human lysophosphatidic acid acyltransferase that is encoded by a gene located in the class III region of the human major histocompatibility complex. (PubMed id 9461603)1, 2, 3, 9 Aguado B. and Campbell R.D. (1998)
    2. A human cDNA sequence with homology to non-mammalian lysophosphatidic acid acyltransferases. (PubMed id 9291118)1, 2, 3 Stamps A.C....Finnen M.J. (1997)
    3. Cloning and expression of two human lysophosphatidic acid acyltransferase cDNAs that enhance cytokine-induced signaling responses in cells. (PubMed id 9212163)1, 2, 9 West J.... Leung D.W. (1997)
    4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    5. The DNA sequence and analysis of human chromosome 6. (PubMed id 14574404)1, 2 Mungall A.J.... Beck S. (2003)
    6. Analysis of the gene-dense major histocompatibility complex class III region and its comparison to mouse. (PubMed id 14656967)1, 2 Xie T.... Hood L. (2003)
    7. The structure and functions of human lysophosphatidic acid acyltransferases. (PubMed id 11487472)1, 9 Leung D.W. (2001)
    8. Genome-wide association study identifies novel loci as sociated with circulating phospho- and sphingolipid concentrations. (PubMed id 22359512)1 Demirkan A....Schmitz G. (2012)
    9. The proteomic analysis of endogenous FAT10 substrates identifies p62/SQSTM1 as a substrate of FAT10ylation. (PubMed id 22797925)1 Aichem A....Groettrup M. (2012)
    10. Ubiquitin-mediated proteolysis of HuR by heat shock. (PubMed id 19322201)1 Abdelmohsen K....Gorospe M. (2009)

    External Searches for AGPAT1 gene

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Disorders
    Free Text  
      Query String
    		PubMed
    OMIM
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      (Note: In FireFox, select the above section and copy using Ctrl-C)

    Genome Databases showing AGPAT1 gene

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 10554 HGNC: 324 AceView: AGPAT1 Ensembl:ENSG00000204310 euGenes: HUgn10554
    ECgene: AGPAT1 Kegg: 10554 H-InvDB: AGPAT1

    Other Databases showing AGPAT1 gene

    (According to HUGE)
    About This Section
    		   --

    Specialized Databases showing AGPAT1 gene

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for AGPAT1 Pharmacogenomics, SNPs, Pathways

    Intellectual Property
    for AGPAT1 gene

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    		Patent Information for AGPAT1 gene:
    Search GeneIP for patents involving AGPAT1

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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