Aliases for AGPAT1 Gene
External Ids for AGPAT1 Gene
Previous GeneCards Identifiers for AGPAT1 Gene
This gene encodes an enzyme that converts lysophosphatidic acid (LPA) into phosphatidic acid (PA). LPA and PA are two phospholipids involved in signal transduction and in lipid biosynthesis in cells. This enzyme localizes to the endoplasmic reticulum. This gene is located in the class III region of the human major histocompatibility complex. Alternative splicing results in two transcript variants encoding the same protein. [provided by RefSeq, Jul 2008]
GeneCards Summary for AGPAT1 Gene
AGPAT1 (1-Acylglycerol-3-Phosphate O-Acyltransferase 1) is a Protein Coding gene. Among its related pathways are Regulation of lipid metabolism by Peroxisome proliferator-activated receptor alpha (PPARalpha) and triacylglycerol biosynthesis. GO annotations related to this gene include transferase activity, transferring acyl groups and 1-acylglycerol-3-phosphate O-acyltransferase activity. An important paralog of this gene is AGPAT2.
UniProtKB/Swiss-Prot for AGPAT1 Gene
Converts lysophosphatidic acid (LPA) into phosphatidic acid by incorporating an acyl moiety at the sn-2 position of the glycerol backbone.