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AGPAT1 Gene

protein-coding   GIFtS: 63
GCID: GC06M032135

1-Acylglycerol-3-Phosphate O-Acyltransferase 1

(Previous names: 1-acylglycerol-3-phosphate O-acyltransferase 1 (lysophosphatidic...)
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
1-Acylglycerol-3-Phosphate O-Acyltransferase 11 2 3     LPAATA2 5
1-Acylglycerol-3-Phosphate O-Acyltransferase 1 (Lysophosphatidic Acid
Acyltransferase, Alpha)1 2
     alpha1
Lysophosphatidic Acid Acyltransferase Alpha2 3     Lysophosphatidic Acid Acyltransferase1
1-AGP Acyltransferase 12 3     1-AGPAT12
1-AGPAT 12 3     1-Acyl-Sn-Glycerol-3-Phosphate Acyltransferase Alpha2
G152 3     1-Acylglycerol-3-Phosphate O-Acyltransferase 1 (Acetoacetly Coenzyme A
Thiolase)2
LPAAT-alpha2 3     Lysophospholipid Acyltransferase2
EC 2.3.1.513 8     Protein G153

External Ids:    HGNC: 3241   Entrez Gene: 105542   Ensembl: ENSG000002043107   OMIM: 6030995   UniProtKB: Q999433   

Export aliases for AGPAT1 gene to outside databases

Previous GC identifers: GC06M032163 GC06M031906 GC06M032207 GC06M032243 GC06M031890


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for AGPAT1 Gene:
This gene encodes an enzyme that converts lysophosphatidic acid (LPA) into phosphatidic acid (PA). LPA and PA are
two phospholipids involved in signal transduction and in lipid biosynthesis in cells. This enzyme localizes to
the endoplasmic reticulum. This gene is located in the class III region of the human major histocompatibility
complex. Alternative splicing results in two transcript variants encoding the same protein. (provided by RefSeq,
Jul 2008)

GeneCards Summary for AGPAT1 Gene:
AGPAT1 (1-acylglycerol-3-phosphate O-acyltransferase 1) is a protein-coding gene. Diseases associated with AGPAT1 include aspergillosis, and lipodystrophy. GO annotations related to this gene include 1-acylglycerol-3-phosphate O-acyltransferase activity. An important paralog of this gene is AGPAT2.

UniProtKB/Swiss-Prot: PLCA_HUMAN, Q99943
Function: Converts lysophosphatidic acid (LPA) into phosphatidic acid by incorporating an acyl moiety at the sn-2
position of the glycerol backbone

Gene Wiki entry for AGPAT1 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence:
NC_000006.12  NT_007592.16  NT_113891.3  NT_167244.2  NT_167246.2  NT_167247.2  NT_167248.2  NT_167249.2  
NC_018917.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the AGPAT1 gene promoter:
         E2F-3a   E2F-4   HEN1   E2F-5   STAT3   E47   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmids (see all 2): AGPAT1 promoter sequence
   Search Chromatin IP Primers for AGPAT1

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat AGPAT1


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 6p21.3   Ensembl cytogenetic band:  6p21.32   HGNC cytogenetic band: 6p21.3

AGPAT1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
AGPAT1 gene location

GeneLoc information about chromosome 6         GeneLoc Exon Structure

GeneLoc location for GC06M032135:  view genomic region     (about GC identifiers)

Start:
32,135,983 bp from pter      End:
32,145,888 bp from pter
Size:
9,906 bases      Orientation:
minus strand

6 alternative locations:
Chr6-,NT_167248 3,397,003-3,406,908      Chr6-,NT_167246 3,478,807-3,488,712      Chr6-,NT_167244 3,450,724-3,460,629     
Chr6-,NT_113891.2 3,606,664-3,616,569      Chr6-,NT_167247 3,515,812-3,525,717      Chr6-,NT_167249 3,483,711-3,493,616     

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: PLCA_HUMAN, Q99943 (See protein sequence)
Recommended Name: 1-acyl-sn-glycerol-3-phosphate acyltransferase alpha precursor  
Size: 283 amino acids; 31717 Da
Sequence caution: Sequence=AAB47493.1; Type=Erroneous initiation; Note=Translation N-terminally extended;
Secondary accessions: A2BFI5 Q5BL03

Explore the universe of human proteins at neXtProt for AGPAT1: NX_Q99943

Explore proteomics data for AGPAT1 at MOPED

Post-translational modifications: 

  • Modification sites at neXtProt
  • Modification sites at PhosphoSitePlus
  • Selected DME Specific Peptides for AGPAT1 (Q99943) (see all 7)
     VRHSMLT  NHQSSLD  PIVMSSYQDFY  KYLYGIRVEVRGAHHFPP 


    See AGPAT1 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (2 alternative transcripts): 
    NP_006402.1  NP_116130.2  

    ENSEMBL proteins: 
     ENSP00000378874   ENSP00000364248   ENSP00000378877   ENSP00000364245   ENSP00000378875  
     ENSP00000337463   ENSP00000410473  
    Reactome Protein details: Q99943

    AGPAT1 Human Recombinant Protein Products:

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    Novus Biologicals AGPAT1 Protein
    Novus Biologicals AGPAT1 Lysates
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    Cloud-Clone Corp. Proteins for AGPAT1

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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    AGPAT: 1-acylglycerol-3-phosphate O-acyltransferases

    2 InterPro protein domains:
     IPR004552 AGP_acyltrans
     IPR002123 Plipid/glycerol_acylTrfase

    Graphical View of Domain Structure for InterPro Entry Q99943

    ProtoNet protein and cluster: Q99943

    1 Blocks protein domain: IPB002123 Phospholipid/glycerol acyltransferase

    UniProtKB/Swiss-Prot: PLCA_HUMAN, Q99943
    Domain: The HXXXXD motif is essential for acyltransferase activity and may constitute the binding site for the
    phosphate moiety of the glycerol-3-phosphate (By similarity)
    Similarity: Belongs to the 1-acyl-sn-glycerol-3-phosphate acyltransferase family


    AGPAT1 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: PLCA_HUMAN, Q99943
    Function: Converts lysophosphatidic acid (LPA) into phosphatidic acid by incorporating an acyl moiety at the sn-2
    position of the glycerol backbone
    Catalytic activity: Acyl-CoA + 1-acyl-sn-glycerol 3-phosphate = CoA + 1,2-diacyl-sn-glycerol 3-phosphate

         Genatlas biochemistry entry for AGPAT1:
    lysophosphatidic acid acyltransferase alpha,expressed in many tissues with highest expression in skeletal
    muscle,localized in endoplasmic reticulum

         Enzyme Number (IUBMB): EC 2.3.1.511 2

         Gene Ontology (GO): 2 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:00038411-acylglycerol-3-phosphate O-acyltransferase activity IGI9212163
    GO:0016746transferase activity, transferring acyl groups ----
         
    AGPAT1 for ontologies           About GeneDecksing


    Phenotypes:
         1 MGI phenotypic allele for Agpat1 (no phenotypes)

    AGPAT1 for phenotypes           About GeneDecksing

    Animal Models:
       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for AGPAT1
       inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for AGPAT1

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for AGPAT1
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for AGPAT1

    miRNA
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    miRTarBase miRNAs that target AGPAT1:
    hsa-mir-7-5p (MIRT025835), hsa-mir-193b-3p (MIRT016494)

    Block miRNA regulation of human, mouse, rat AGPAT1 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate AGPAT1 (see all 12):
    hsa-miR-548am hsa-miR-548d-3p hsa-miR-769-5p hsa-miR-3065-3p hsa-miR-4290 hsa-miR-548aa hsa-miR-1205 hsa-miR-1291
    SwitchGear 3'UTR luciferase reporter plasmidAGPAT1 3' UTR sequence
    Inhib. RNA
    Products:
        
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    Predesigned siRNA for gene silencing in human, mouse, rat AGPAT1

    Gene Editing
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    Clone
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    GenScript: all cDNA clones in your preferred vector (see all 2): AGPAT1 (NM_032741)
    Sino Biological Human cDNA Clone for AGPAT1
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for AGPAT1
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat AGPAT1

    Cell Line
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    In Situ Assay
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for AGPAT1


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    PLCA_HUMAN, Q99943: Endoplasmic reticulum membrane; Multi-pass membrane protein
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    endoplasmic reticulum4
    plasma membrane2
    extracellular1

    Gene Ontology (GO): 4 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005783endoplasmic reticulum TAS9461603
    GO:0005789endoplasmic reticulum membrane TAS--
    GO:0016020membrane ----
    GO:0016021integral component of membrane IEA--

    AGPAT1 for ontologies           About GeneDecksing


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for AGPAT1 About   (see all 8)  
    See pathways by source

    SuperPathContained pathways About
    1Glycerophospholipid biosynthesis
    Glycerophospholipid biosynthesis0.64
    Glycerophospholipid metabolism0.62
    Phospholipid metabolism0.64
    Synthesis of PA0.33
    2triacylglycerol biosynthesis
    triacylglycerol biosynthesis0.48
    Triacylglyceride Synthesis0.36
    phosphatidylglycerol biosynthesis II (non-plastidic)0.48
    CDP-diacylglycerol biosynthesis I0.00
    3Metabolism
    Metabolism0.38
    Metabolism of lipids and lipoproteins0.37
    Metabolic pathways0.38
    4Integration of energy metabolism
    Integration of energy metabolism0.75
    ChREBP activates metabolic gene expression0.00
    5Fatty acid, triacylglycerol, and ketone body metabolism
    Fatty acid, triacylglycerol, and ketone body metabolism0.65

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways


    4 BioSystems Pathways for AGPAT1
        CDP-diacylglycerol biosynthesis I
    Triacylglyceride Synthesis
    triacylglycerol biosynthesis
    phosphatidylglycerol biosynthesis II (non-plastidic)


    3 Reactome Pathways for AGPAT1
        Synthesis of PA
    ChREBP activates metabolic gene expression
    Triglyceride Biosynthesis


    4 Kegg Pathways  (Kegg details for AGPAT1):
        Glycerolipid metabolism
    Glycerophospholipid metabolism
    Metabolic pathways
    Fat digestion and absorption

    UniProtKB/Swiss-Prot: PLCA_HUMAN, Q99943
    Pathway: Phospholipid metabolism; CDP-diacylglycerol biosynthesis; CDP-diacylglycerol from sn-glycerol
    3-phosphate: step 2/3


    AGPAT1 for pathways           About GeneDecksing

        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for AGPAT1
    Interactions:

        Search GeneGlobe Interaction Network for AGPAT1

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for AGPAT1 (Q999433 ENSP000003374634) via UniProtKB, MINT, STRING, and/or I2D (see all 63)

    InteractantInteraction Details
    GeneCardExternal ID(s)
    ARFGEF1Q9Y6D63, ENSP000002622154I2D: score=3 STRING: ENSP00000262215
    CAP2P401233, ENSP000002299224I2D: score=3 STRING: ENSP00000229922
    KIAA0368Q5VYK33, ENSP000002593354I2D: score=3 STRING: ENSP00000259335
    SPTLC1O152693, ENSP000002625544I2D: score=1 STRING: ENSP00000262554
    CCT4P509913, ENSP000003779584I2D: score=3 STRING: ENSP00000377958
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 13):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0001819positive regulation of cytokine production IMP9212163
    GO:0001961positive regulation of cytokine-mediated signaling pathway IC9212163
    GO:0006112energy reserve metabolic process TAS--
    GO:0006644phospholipid metabolic process TAS--
    GO:0006654phosphatidic acid biosynthetic process TAS--

    AGPAT1 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for AGPAT1 (PLCA)

    Selected HMDB Compounds for AGPAT1 (see all 55)    About this table
    CompoundSynonyms CAS #PubMed Ids
    (2E)-Decenoyl-CoA(E)-S-2-decenoate Coenzyme A (see all 15)10018-95-8--
    (2E)-Dodecenoyl-CoA2-trans-Dodecenoyl-Coenzyme A (see all 4)1066-12-2--
    (2E)-Hexadecenoyl-CoAtrans-2-Hexadecenoyl-CoA (see all 4)4460-95-1--
    (2E)-Octenoyl-CoA(E)-S-2-octenoate Coenzyme A (see all 16)10018-94-7--
    (2E)-Tetradecenoyl-CoA(2E)-Tetradecenoyl-Coenzyme A (see all 8)38795-33-4--
    2-Methylbutyryl-CoA2-methylbutanoyl-CoA (see all 11)6712-02-3--
    2-Methylhexanoyl-CoA2-Methylhexanoyl-CoEnzyme A (see all 5)----
    3Z-dodecenoyl-CoAS-[2-[3-[[(2R)-4-[[[(2R,3R,5R)-5-(6-aminopurin-9-yl)-4-hydroxy-3-phosphonooxyoxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-hydroxyphosphoryl]oxy-2-hydroxy-3,3-dimethylbutanoyl]amino]propanoylamino]ethyl] (Z)-dodec-3-enethioate (see all 4)2152-91-2--
    Acetyl-CoAS-Acetyl coenzyme A (see all 13)72-89-9--
    Acrylyl-CoAAcryloyl coenzyme A (see all 14)5776-58-9--

    6 Novoseek inferred chemical compound relationships for AGPAT1 gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    lysophospholipid 96.6 48 2105213 (9), 20238429 (3), 18538854 (3), 15972316 (3) (see all 27)
    arachidonic acid 69.1 8 2105213 (2), 9250613 (1), 10793640 (1), 18772128 (1) (see all 6)
    acyl-coa 68.4 11 8547334 (2), 9610838 (2), 18156367 (1), 9182714 (1) (see all 6)
    phospholipid 63.1 6 9453575 (1), 9250613 (1), 7702576 (1), 18403647 (1)
    phosphatidylcholine 45.3 1 11243703 (1)
    fatty acid 34.4 1 9250613 (1)



    AGPAT1 for compounds           About GeneDecksing



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
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    REFSEQ mRNAs for AGPAT1 gene (2 alternative transcripts): 
    NM_006411.3  NM_032741.4  

    Unigene Cluster for AGPAT1:

    1-acylglycerol-3-phosphate O-acyltransferase 1
    Hs.409230  [show with all ESTs]
    Unigene Representative Sequence: AK056346
    9 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000395496 ENST00000375107(uc003oae.3 uc011dpk.2 uc003oai.1 uc011dpl.2)
    ENST00000395499 ENST00000375104 ENST00000490711(uc003oag.3) ENST00000395497
    ENST00000336984(uc003oah.3) ENST00000476663 ENST00000412465
    miRNA
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    hsa-miR-548am hsa-miR-548d-3p hsa-miR-769-5p hsa-miR-3065-3p hsa-miR-4290 hsa-miR-548aa hsa-miR-1205 hsa-miR-1291
    SwitchGear 3'UTR luciferase reporter plasmidAGPAT1 3' UTR sequence
    Inhib. RNA
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    GenScript: all cDNA clones in your preferred vector (see all 2): AGPAT1 (NM_032741)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for AGPAT1
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat AGPAT1
    Primer
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    OriGene qPCR primer pairs and template standards for AGPAT1
    OriGene qSTAR qPCR primer pairs in human, mouse for AGPAT1
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat AGPAT1
      QuantiTect SYBR Green Assays in human, mouse, rat AGPAT1
      QuantiFast Probe-based Assays in human, mouse, rat AGPAT1

    Additional mRNA sequence: 

    AF007145.1 AK056346.1 AK058025.1 AK129818.1 AK299252.1 AK315950.1 BC002402.2 BC003007.1 
    BC004310.1 BC006818.1 BC090849.1 U56417.1 U75971.1 Y09565.1 

    Selected DOTS entries (see all 27):

    DT.97802534  DT.100045133  DT.121378221  DT.86840553  DT.121378245  DT.100844873  DT.95267539  DT.121378455 
    DT.91831976  DT.448281  DT.100705504  DT.454641  DT.121378279  DT.121378323  DT.95267517  DT.95267521 
    DT.100852579  DT.121378294  DT.100045129  DT.100807740  DT.121378254  DT.121378313  DT.121378397  DT.92399762 

    Selected AceView cDNA sequences (see all 364):

    BU540493 BQ071216 BQ679139 BU844515 BU166855 AA604276 AU132404 BU170828 
    BQ058976 AI208159 BQ892739 AI460221 AL119210 AI128547 BQ688445 BQ183925 
    AI220581 BQ017324 AI700774 BU944038 BQ877591 AA319367 BC004310 BU157927 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    AGPAT1 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: ACCCCACCCA
    AGPAT1 Expression
    About this image

    AGPAT1 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    AGPAT1 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.409230

    UniProtKB/Swiss-Prot: PLCA_HUMAN, Q99943
    Tissue specificity: Widely expressed. Expressed in adipose tissue and at high levels in testis and pancreas.
    Expressed at lower levels in tissues such as heart, brain, placenta, kidney, lung, spleen, thymus, prostate,
    ovary, intestine, colon, leukocyte and liver

        Custom PCR Arrays for AGPAT1
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    In Situ
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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of animals and fungi.

    Orthologs for AGPAT1 gene from Selected species (see all 16)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Agpat11 , 5 1-acylglycerol-3-phosphate O-acyltransferase 1 (lysophosphatidic more1, 5 89.17(n)1
    92.5(a)1
      17 (18.18 cM)5
    559791  NM_018862.31  NP_061350.31 
     346042625 
    chicken
    (Gallus gallus)
    Aves --
    --
    Uncharacterized protein
    53(a)
    47(a)
    many ↔ many
    many ↔ many
    27(1674740-1678268)
    19(401448-406341)
    lizard
    (Anolis carolinensis)
    Reptilia AGPAT16
    1-acylglycerol-3-phosphate O-acyltransferase 1
    61(a)
    1 ↔ 1
    2(198698983-198722628)
    African clawed frog
    (Xenopus laevis)
    Amphibia Xl.151982 Xenopus laevis transcribed sequence with moderate similarity more 73.54(n)    BJ035411.1 
    zebrafish
    (Danio rerio)
    Actinopterygii agpat21 1-acylglycerol-3-phosphate O-acyltransferase 2 (lysophosphatidic more 58.06(n)
    54.1(a)
      777624  NM_001077732.1  NP_001071200.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta CG38121 , 3 1-acylglycerol-3-phosphate
    O-acyltransferase3
    CG38121
    41(a)
    (best of 2)3
    50(n)1
    40.7(a)1
      322301  NM_167337.21  NP_727641.11 
    worm
    (Caenorhabditis elegans)
    Secernentea T06E8.13
    acl-21
    1-acyl-SN-glycerol-3-phophate
    acyltransferase3
    acl-21
    41(a)3
    48.6(n)1
    41.58(a)1
      V(10030899-10033686)3
    1793981  NM_001269246.11  NP_001256175.11 
    baker's yeast
    (Saccharomyces cerevisiae)
    Saccharomycetes SLC1(YDL052C)4 1-acyl-sn-glycerol-3-phosphate acyltransferase, catalyzes more   --   4(363583-362672) 851508  NP_010231.1 


    ENSEMBL Gene Tree for AGPAT1 (if available)
    TreeFam Gene Tree for AGPAT1 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for AGPAT1 gene
    AGPAT22  
    1 SIMAP similar gene for AGPAT1 using alignment to 2 protein entries:     PLCA_HUMAN (see all proteins):
    AGPAT2

    AGPAT1 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for AGPAT1 (see all 116)    About this table    
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 6 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1394270261,2
    --32136593(+) AGGGCA/GAGAAG 2 -- ut310--------
    rs115534301,2
    C,F,H--32136771(-) CCAGTG/AACTCA 2 -- ut315Minor allele frequency- A:0.02NS NA 720
    rs10618071,2
    C,F,H--32136838(-) GCAGTC/TTCCAC 2 -- ut3120Minor allele frequency- T:0.15NS EA MN NA 2824
    rs1840932181,2
    --32136846(+) TGCACC/TGAGGC 2 -- ut310--------
    rs1161884561,2
    C,F--32136912(+) CTTCAG/AAAGTT 2 -- ut311Minor allele frequency- A:0.02WA 118
    rs12698391,2
    C,F,H--32136930(+) CCAAAG/TAGGAG 2 -- ut31 trp316Minor allele frequency- T:0.05EA NA MN NS CSA WA 1947
    rs172016721,2
    F--32137272(+) CTTTGC/GCCACA 2 -- int11Minor allele frequency- G:0.03MN 96
    rs1500650961,2
    C--32137448(+) CCCCCC/GTCCTC 2 -- int10--------
    rs2008055311,2
    C--32137537(+) TAGTAA/CCAGCC 2 -- int10--------
    rs1453922291,2
    C--32137698(+) TCCCAA/GCCTCT 2 -- int10--------

    HapMap Linkage Disequilibrium report for AGPAT1 (32135983 - 32145888 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 5 variations for AGPAT1:    About this table    
    Variant IDTypeSubtypePubMed ID
    esv24778CNV Loss19812545
    nsv884707CNV Loss21882294
    nsv884706CNV Loss21882294
    nsv830629CNV Loss17160897
    dgv1929e1CNV Complex17122850

    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing AGPAT1
    DNA2.0 Custom Variant and Variant Library Synthesis for AGPAT1

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 603099    OMIM disorders: --

    9 diseases for AGPAT1:    
    About MalaCards
    aspergillosis    lipodystrophy    sepsis    type 1 diabetes
    systemic lupus erythematosus    lupus erythematosus    tuberculosis    alzheimer's disease
    malaria


    AGPAT1 for disorders           About GeneDecksing

    1 Novoseek inferred disease relationship for AGPAT1 gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    inflammation 0 2 12965115 (1), 18538854 (1)

    Genetic Association Database (GAD): AGPAT1
    Human Genome Epidemiology (HuGE) Navigator: AGPAT1 (4 documents)

    Export disorders for AGPAT1 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for AGPAT1 gene, integrated from 10 sources (see all 64):
    (articles sorted by number of sources associating them with AGPAT1)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Characterization of a human lysophosphatidic acid acyltransferase that is encoded by a gene located in the class III region of the human major histocompatibility complex. (PubMed id 9461603)1, 2, 3, 9 Aguado B. and Campbell R.D. (J. Biol. Chem. 1998)
    2. A human cDNA sequence with homology to non-mammalian lysophosphatidic acid acyltransferases. (PubMed id 9291118)1, 2, 3 Stamps A.C....Finnen M.J. (Biochem. J. 1997)
    3. Cloning and expression of two human lysophosphatidic acid acyltransferase cDNAs that enhance cytokine-induced signaling responses in cells. (PubMed id 9212163)1, 2, 9 West J.... Leung D.W. (DNA Cell Biol. 1997)
    4. Genome-wide association study identifies novel loci associated with circulating phospho- and sphingolipid concentrations. (PubMed id 22359512)1, 4 Demirkan A....Schmitz G. (PLoS Genet. 2012)
    5. Association of MHC SNP genotype with susceptibility to type 1 diabetes: a modified survival approach. (PubMed id 19143821)1, 4 McKinnon E....James I. (amp 2009)
    6. High-density SNP screening of the major histocompatibility complex in systemic lupus erythematosus demonstrates strong evidence for independent susceptibility regions. (PubMed id 19851445)1, 4 Barcellos L.F....Criswell L.A. (PLoS Genet. 2009)
    7. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    8. Analysis of the gene-dense major histocompatibility complex class III region and its comparison to mouse. (PubMed id 14656967)1, 2 Xie T.... Hood L. (Genome Res. 2003)
    9. The DNA sequence and analysis of human chromosome 6. (PubMed id 14574404)1, 2 Mungall A.J.... Beck S. (Nature 2003)
    10. The structure and functions of human lysophosphatidic acid acyltransferases. (PubMed id 11487472)1, 9 Leung D.W. (Front. Biosci. 2001)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 10554 HGNC: 324 AceView: AGPAT1 Ensembl:ENSG00000204310 euGenes: HUgn10554
    ECgene: AGPAT1 Kegg: 10554 H-InvDB: AGPAT1

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for AGPAT1 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for AGPAT1 gene:
    Search GeneIP for patents involving AGPAT1

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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