Free for academic non-profit institutions. Other users need a Commercial license

Aliases for AGPAT1 Gene

Aliases for AGPAT1 Gene

  • 1-Acylglycerol-3-Phosphate O-Acyltransferase 1 2 3 4
  • 1-Acylglycerol-3-Phosphate O-Acyltransferase 1 (Lysophosphatidic Acid Acyltransferase, Alpha) 2 3
  • Lysophosphatidic Acid Acyltransferase Alpha 3 4
  • 1-AGP Acyltransferase 1 3 4
  • LPAAT-Alpha 3 4
  • EC 2.3.1.51 4 64
  • 1-AGPAT 1 3 4
  • LPAATA 3 6
  • G15 3 4
  • 1-Acylglycerol-3-Phosphate O-Acyltransferase 1 (Acetoacetly Coenzyme A Thiolase) 3
  • 1-Acyl-Sn-Glycerol-3-Phosphate Acyltransferase Alpha 3
  • Lysophosphatidic Acid Acyltransferase 2
  • Lysophospholipid Acyltransferase 3
  • Protein G15 4
  • 1-AGPAT1 3
  • Alpha 2

External Ids for AGPAT1 Gene

Summaries for AGPAT1 Gene

Entrez Gene Summary for AGPAT1 Gene

  • This gene encodes an enzyme that converts lysophosphatidic acid (LPA) into phosphatidic acid (PA). LPA and PA are two phospholipids involved in signal transduction and in lipid biosynthesis in cells. This enzyme localizes to the endoplasmic reticulum. This gene is located in the class III region of the human major histocompatibility complex. Alternative splicing results in two transcript variants encoding the same protein. [provided by RefSeq, Jul 2008]

GeneCards Summary for AGPAT1 Gene

AGPAT1 (1-Acylglycerol-3-Phosphate O-Acyltransferase 1) is a Protein Coding gene. Among its related pathways are Metabolism and Metabolism. GO annotations related to this gene include 1-acylglycerol-3-phosphate O-acyltransferase activity. An important paralog of this gene is AGPAT2.

UniProtKB/Swiss-Prot for AGPAT1 Gene

  • Converts lysophosphatidic acid (LPA) into phosphatidic acid by incorporating an acyl moiety at the sn-2 position of the glycerol backbone.

Gene Wiki entry for AGPAT1 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for AGPAT1 Gene

Genomics for AGPAT1 Gene

Genomic Location for AGPAT1 Gene

Start:
32,168,206 bp from pter
End:
32,178,111 bp from pter
Size:
9,906 bases
Orientation:
Minus strand

Genomic View for AGPAT1 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for AGPAT1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

Regulatory Elements for AGPAT1 Gene

Proteins for AGPAT1 Gene

  • Protein details for AGPAT1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q99943-PLCA_HUMAN
    Recommended name:
    1-acyl-sn-glycerol-3-phosphate acyltransferase alpha
    Protein Accession:
    Q99943
    Secondary Accessions:
    • A2BFI5
    • Q5BL03

    Protein attributes for AGPAT1 Gene

    Size:
    283 amino acids
    Molecular mass:
    31717 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=AAB47493.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305};

neXtProt entry for AGPAT1 Gene

Proteomics data for AGPAT1 Gene at MOPED

Post-translational modifications for AGPAT1 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for AGPAT1 Gene

Domains for AGPAT1 Gene

Gene Families for AGPAT1 Gene

HGNC:
  • AGPAT :1-acylglycerol-3-phosphate O-acyltransferases

Protein Domains for AGPAT1 Gene

UniProtKB/Swiss-Prot:

PLCA_HUMAN
Domain:
  • The HXXXXD motif is essential for acyltransferase activity and may constitute the binding site for the phosphate moiety of the glycerol-3-phosphate.:
    • Q99943
Family:
  • Belongs to the 1-acyl-sn-glycerol-3-phosphate acyltransferase family.:
    • Q99943
genes like me logo Genes that share domains with AGPAT1: view

Function for AGPAT1 Gene

Molecular function for AGPAT1 Gene

GENATLAS Biochemistry: lysophosphatidic acid acyltransferase alpha,expressed in many tissues with highest expression in skeletal muscle,localized in endoplasmic reticulum
UniProtKB/Swiss-Prot CatalyticActivity: Acyl-CoA + 1-acyl-sn-glycerol 3-phosphate = CoA + 1,2-diacyl-sn-glycerol 3-phosphate.
UniProtKB/Swiss-Prot Function: Converts lysophosphatidic acid (LPA) into phosphatidic acid by incorporating an acyl moiety at the sn-2 position of the glycerol backbone.

Enzyme Numbers (IUBMB) for AGPAT1 Gene

Gene Ontology (GO) - Molecular Function for AGPAT1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003841 1-acylglycerol-3-phosphate O-acyltransferase activity IGI 9212163
GO:0005515 protein binding IPI 25416956
GO:0016746 transferase activity, transferring acyl groups --
genes like me logo Genes that share ontologies with AGPAT1: view

miRNA for AGPAT1 Gene

miRTarBase miRNAs that target AGPAT1

No data available for Phenotypes , Animal Models , Transcription Factor Targeting and HOMER Transcription for AGPAT1 Gene

Localization for AGPAT1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for AGPAT1 Gene

Endoplasmic reticulum membrane; Multi-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for AGPAT1 Gene COMPARTMENTS Subcellular localization image for AGPAT1 gene
Compartment Confidence
endoplasmic reticulum 4
plasma membrane 2
extracellular 1

Gene Ontology (GO) - Cellular Components for AGPAT1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005783 endoplasmic reticulum TAS 9461603
GO:0005789 endoplasmic reticulum membrane TAS --
GO:0016020 membrane IDA 19946888
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with AGPAT1: view

Pathways for AGPAT1 Gene

genes like me logo Genes that share pathways with AGPAT1: view

UniProtKB/Swiss-Prot Q99943-PLCA_HUMAN

  • Pathway: Phospholipid metabolism; CDP-diacylglycerol biosynthesis; CDP-diacylglycerol from sn-glycerol 3-phosphate: step 2/3

Gene Ontology (GO) - Biological Process for AGPAT1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001819 positive regulation of cytokine production IMP 9212163
GO:0001961 positive regulation of cytokine-mediated signaling pathway IC 9212163
GO:0006112 energy reserve metabolic process TAS --
GO:0006644 phospholipid metabolic process TAS --
GO:0006654 phosphatidic acid biosynthetic process TAS --
genes like me logo Genes that share ontologies with AGPAT1: view

Compounds for AGPAT1 Gene

(55) HMDB Compounds for AGPAT1 Gene

Compound Synonyms Cas Number PubMed IDs
(2E)-Decenoyl-CoA
  • (E)-S-2-decenoate Coenzyme A
10018-95-8
(2E)-Dodecenoyl-CoA
  • 2-trans-Dodecenoyl-Coenzyme A
1066-12-2
(2E)-Hexadecenoyl-CoA
  • trans-2-Hexadecenoyl-CoA
4460-95-1
(2E)-Octenoyl-CoA
  • (E)-S-2-octenoate Coenzyme A
10018-94-7
(2E)-Tetradecenoyl-CoA
  • (2E)-Tetradecenoyl-Coenzyme A
38795-33-4

(6) Novoseek inferred chemical compound relationships for AGPAT1 Gene

Compound -log(P) Hits PubMed IDs
lysophospholipid 96.6 47
arachidonic acid 69.1 7
acyl-coa 68.4 8
phospholipid 63.1 4
phosphatidylcholine 45.3 1
genes like me logo Genes that share compounds with AGPAT1: view

Transcripts for AGPAT1 Gene

Unigene Clusters for AGPAT1 Gene

1-acylglycerol-3-phosphate O-acyltransferase 1:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for AGPAT1 Gene

No ASD Table

Relevant External Links for AGPAT1 Gene

GeneLoc Exon Structure for
AGPAT1
ECgene alternative splicing isoforms for
AGPAT1

Expression for AGPAT1 Gene

mRNA expression in normal human tissues for AGPAT1 Gene

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for AGPAT1 Gene

SOURCE GeneReport for Unigene cluster for AGPAT1 Gene Hs.409230

mRNA Expression by UniProt/SwissProt for AGPAT1 Gene

Q99943-PLCA_HUMAN
Tissue specificity: Widely expressed. Expressed in adipose tissue and at high levels in testis and pancreas. Expressed at lower levels in tissues such as heart, brain, placenta, kidney, lung, spleen, thymus, prostate, ovary, intestine, colon, leukocyte and liver.
genes like me logo Genes that share expressions with AGPAT1: view

Orthologs for AGPAT1 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for AGPAT1 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia AGPAT1 36
  • 99.88 (n)
  • 100 (a)
AGPAT1 37
  • 100 (a)
OneToOne
cow
(Bos Taurus)
Mammalia AGPAT1 36
  • 93.4 (n)
  • 97.53 (a)
AGPAT1 37
  • 96 (a)
OneToOne
dog
(Canis familiaris)
Mammalia AGPAT1 36
  • 93.4 (n)
  • 96.11 (a)
AGPAT1 37
  • 95 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Agpat1 36
  • 89.17 (n)
  • 92.5 (a)
Agpat1 16
Agpat1 37
  • 91 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia AGPAT1 37
  • 92 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia AGPAT1 37
  • 71 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Agpat1 36
  • 89.64 (n)
  • 93.93 (a)
chicken
(Gallus gallus)
Aves -- 37
  • 47 (a)
ManyToMany
-- 37
  • 53 (a)
ManyToMany
lizard
(Anolis carolinensis)
Reptilia AGPAT1 37
  • 61 (a)
OneToOne
African clawed frog
(Xenopus laevis)
Amphibia Xl.15198 36
tropical clawed frog
(Silurana tropicalis)
Amphibia agpat1 36
  • 65.75 (n)
  • 74.02 (a)
Str.17787 36
zebrafish
(Danio rerio)
Actinopterygii agpat2 36
  • 58.06 (n)
  • 54.1 (a)
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP002021 36
  • 51.22 (n)
  • 39.84 (a)
fruit fly
(Drosophila melanogaster)
Insecta CG3812 36
  • 50 (n)
  • 40.7 (a)
CG3812 37
  • 33 (a)
ManyToMany
fu12 37
  • 30 (a)
ManyToMany
fu12 38
  • 33 (a)
CG3812 38
  • 41 (a)
worm
(Caenorhabditis elegans)
Secernentea acl-1 37
  • 28 (a)
ManyToMany
acl-2 36
  • 48.6 (n)
  • 41.58 (a)
acl-2 37
  • 32 (a)
ManyToMany
T06E8.1 38
  • 41 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes SLC1 37
  • 25 (a)
OneToMany
SLC1 39
SLC1 39
Species with no ortholog for AGPAT1:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for AGPAT1 Gene

ENSEMBL:
Gene Tree for AGPAT1 (if available)
TreeFam:
Gene Tree for AGPAT1 (if available)

Paralogs for AGPAT1 Gene

Paralogs for AGPAT1 Gene

Selected SIMAP similar genes for AGPAT1 Gene using alignment to 2 proteins:

genes like me logo Genes that share paralogs with AGPAT1: view

Variants for AGPAT1 Gene

Sequence variations from dbSNP and Humsavar for AGPAT1 Gene

SNP ID Clin Chr 06 pos Sequence Context AA Info Type MAF
rs204997 -- 32,176,234(-) CTGGG(C/G)CGGGG upstream-variant-2KB, intron-variant
rs408359 -- 32,174,106(-) aaaaa(C/T)GCCAG intron-variant
rs417035 -- 32,172,226(-) caagc(A/G)attct intron-variant
rs1061807 -- 32,169,061(-) GCAGT(C/T)TCCAC utr-variant-3-prime
rs1269839 -- 32,169,153(+) CCAAA(G/T)AGGAG utr-variant-3-prime

Structural Variations from Database of Genomic Variants (DGV) for AGPAT1 Gene

Variant ID Type Subtype PubMed ID
dgv1929e1 CNV Complex 17122850
nsv830629 CNV Loss 17160897
nsv884706 CNV Loss 21882294
nsv884707 CNV Loss 21882294
esv24778 CNV Loss 19812545

Relevant External Links for AGPAT1 Gene

HapMap Linkage Disequilibrium report
AGPAT1

Disorders for AGPAT1 Gene

(1) Novoseek inferred disease relationships for AGPAT1 Gene

Disease -log(P) Hits PubMed IDs
inflammation 0 2

Relevant External Links for AGPAT1

Genetic Association Database (GAD)
AGPAT1
Human Genome Epidemiology (HuGE) Navigator
AGPAT1
genes like me logo Genes that share disorders with AGPAT1: view

No data available for UniProtKB/Swiss-Prot for AGPAT1 Gene

Publications for AGPAT1 Gene

  1. Characterization of a human lysophosphatidic acid acyltransferase that is encoded by a gene located in the class III region of the human major histocompatibility complex. (PMID: 9461603) Aguado B. … Campbell R.D. (J. Biol. Chem. 1998) 2 3 4 23
  2. Cloning and expression of two human lysophosphatidic acid acyltransferase cDNAs that enhance cytokine-induced signaling responses in cells. (PMID: 9212163) West J. … Leung D.W. (DNA Cell Biol. 1997) 3 4 23
  3. A human cDNA sequence with homology to non-mammalian lysophosphatidic acid acyltransferases. (PMID: 9291118) Stamps A.C. … Finnen M.J. (Biochem. J. 1997) 2 3 4
  4. The DNA sequence and analysis of human chromosome 6. (PMID: 14574404) Mungall A.J. … Beck S. (Nature 2003) 3 4
  5. Analysis of the gene-dense major histocompatibility complex class III region and its comparison to mouse. (PMID: 14656967) Xie T. … Hood L. (Genome Res. 2003) 3 4

Products for AGPAT1 Gene

  • antibodies-online proteins for AGPAT1
  • antibodies-online antibodies for AGPAT1
  • antibodies-online kits for AGPAT1

Sources for AGPAT1 Gene

Back to Top

Content