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Aliases for AGPAT1 Gene

Aliases for AGPAT1 Gene

  • 1-Acylglycerol-3-Phosphate O-Acyltransferase 1 2 3 4
  • 1-Acylglycerol-3-Phosphate O-Acyltransferase 1 (Lysophosphatidic Acid Acyltransferase, Alpha) 2 3
  • Lysophosphatidic Acid Acyltransferase Alpha 3 4
  • 1-AGP Acyltransferase 1 3 4
  • LPAAT-Alpha 3 4
  • EC 4 63
  • 1-AGPAT 1 3 4
  • LPAATA 3 6
  • G15 3 4
  • 1-Acylglycerol-3-Phosphate O-Acyltransferase 1 (Acetoacetly Coenzyme A Thiolase) 3
  • 1-Acyl-Sn-Glycerol-3-Phosphate Acyltransferase Alpha 3
  • Lysophosphatidic Acid Acyltransferase 2
  • Lysophospholipid Acyltransferase 3
  • Protein G15 4
  • 1-AGPAT1 3
  • Alpha 2

External Ids for AGPAT1 Gene

Previous GeneCards Identifiers for AGPAT1 Gene

  • GC06M032163
  • GC06M031906
  • GC06M032207
  • GC06M032243
  • GC06M031890
  • GC06M032135

Summaries for AGPAT1 Gene

Entrez Gene Summary for AGPAT1 Gene

  • This gene encodes an enzyme that converts lysophosphatidic acid (LPA) into phosphatidic acid (PA). LPA and PA are two phospholipids involved in signal transduction and in lipid biosynthesis in cells. This enzyme localizes to the endoplasmic reticulum. This gene is located in the class III region of the human major histocompatibility complex. Alternative splicing results in two transcript variants encoding the same protein. [provided by RefSeq, Jul 2008]

GeneCards Summary for AGPAT1 Gene

AGPAT1 (1-Acylglycerol-3-Phosphate O-Acyltransferase 1) is a Protein Coding gene. Among its related pathways are Metabolism and Metabolism. GO annotations related to this gene include 1-acylglycerol-3-phosphate O-acyltransferase activity. An important paralog of this gene is AGPAT2.

UniProtKB/Swiss-Prot for AGPAT1 Gene

  • Converts lysophosphatidic acid (LPA) into phosphatidic acid by incorporating an acyl moiety at the sn-2 position of the glycerol backbone.

Gene Wiki entry for AGPAT1 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for AGPAT1 Gene

Genomics for AGPAT1 Gene

Regulatory Elements for AGPAT1 Gene

Genomic Location for AGPAT1 Gene

32,168,206 bp from pter
32,178,111 bp from pter
9,906 bases
Minus strand

Genomic View for AGPAT1 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for AGPAT1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

Proteins for AGPAT1 Gene

  • Protein details for AGPAT1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    1-acyl-sn-glycerol-3-phosphate acyltransferase alpha
    Protein Accession:
    Secondary Accessions:
    • A2BFI5
    • Q5BL03

    Protein attributes for AGPAT1 Gene

    283 amino acids
    Molecular mass:
    31717 Da
    Quaternary structure:
    No Data Available
    • Sequence=AAB47493.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305};

neXtProt entry for AGPAT1 Gene

Proteomics data for AGPAT1 Gene at MOPED

Post-translational modifications for AGPAT1 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for AGPAT1 Gene

Domains for AGPAT1 Gene

Gene Families for AGPAT1 Gene

  • AGPAT :1-acylglycerol-3-phosphate O-acyltransferases

Protein Domains for AGPAT1 Gene

Suggested Antigen Peptide Sequences for AGPAT1 Gene

Graphical View of Domain Structure for InterPro Entry



  • Q99943
  • The HXXXXD motif is essential for acyltransferase activity and may constitute the binding site for the phosphate moiety of the glycerol-3-phosphate.
  • Belongs to the 1-acyl-sn-glycerol-3-phosphate acyltransferase family.
genes like me logo Genes that share domains with AGPAT1: view

Function for AGPAT1 Gene

Molecular function for AGPAT1 Gene

GENATLAS Biochemistry:
lysophosphatidic acid acyltransferase alpha,expressed in many tissues with highest expression in skeletal muscle,localized in endoplasmic reticulum
UniProtKB/Swiss-Prot CatalyticActivity:
Acyl-CoA + 1-acyl-sn-glycerol 3-phosphate = CoA + 1,2-diacyl-sn-glycerol 3-phosphate.
UniProtKB/Swiss-Prot Function:
Converts lysophosphatidic acid (LPA) into phosphatidic acid by incorporating an acyl moiety at the sn-2 position of the glycerol backbone.

Enzyme Numbers (IUBMB) for AGPAT1 Gene

Gene Ontology (GO) - Molecular Function for AGPAT1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003841 1-acylglycerol-3-phosphate O-acyltransferase activity IGI 9212163
GO:0005515 protein binding IPI 25416956
GO:0016746 transferase activity, transferring acyl groups --
genes like me logo Genes that share ontologies with AGPAT1: view

Animal Model Products

miRNA for AGPAT1 Gene

miRTarBase miRNAs that target AGPAT1

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for AGPAT1

In Situ Assay Products

Flow Cytometry Products

No data available for Phenotypes , Animal Models , Transcription Factor Targeting and HOMER Transcription for AGPAT1 Gene

Localization for AGPAT1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for AGPAT1 Gene

Endoplasmic reticulum membrane; Multi-pass membrane protein.

Subcellular locations from

Jensen Localization Image for AGPAT1 Gene COMPARTMENTS Subcellular localization image for AGPAT1 gene
Compartment Confidence
endoplasmic reticulum 4
plasma membrane 2
extracellular 1

Gene Ontology (GO) - Cellular Components for AGPAT1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005783 endoplasmic reticulum TAS 9461603
GO:0005789 endoplasmic reticulum membrane TAS --
GO:0016020 membrane IDA 19946888
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with AGPAT1: view

Pathways for AGPAT1 Gene

genes like me logo Genes that share pathways with AGPAT1: view

UniProtKB/Swiss-Prot Q99943-PLCA_HUMAN

  • Pathway: Phospholipid metabolism; CDP-diacylglycerol biosynthesis; CDP-diacylglycerol from sn-glycerol 3-phosphate: step 2/3

Gene Ontology (GO) - Biological Process for AGPAT1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001819 positive regulation of cytokine production IMP 9212163
GO:0001961 positive regulation of cytokine-mediated signaling pathway IC 9212163
GO:0006112 energy reserve metabolic process TAS --
GO:0006644 phospholipid metabolic process TAS --
GO:0006654 phosphatidic acid biosynthetic process TAS --
genes like me logo Genes that share ontologies with AGPAT1: view

Compounds for AGPAT1 Gene

(55) HMDB Compounds for AGPAT1 Gene

Compound Synonyms Cas Number PubMed IDs
  • (E)-S-2-decenoate Coenzyme A
  • 2-trans-Dodecenoyl-Coenzyme A
  • trans-2-Hexadecenoyl-CoA
  • (E)-S-2-octenoate Coenzyme A
  • (2E)-Tetradecenoyl-Coenzyme A

(6) Novoseek inferred chemical compound relationships for AGPAT1 Gene

Compound -log(P) Hits PubMed IDs
lysophospholipid 96.6 47
arachidonic acid 69.1 7
acyl-coa 68.4 8
phospholipid 63.1 4
phosphatidylcholine 45.3 1
genes like me logo Genes that share compounds with AGPAT1: view

Transcripts for AGPAT1 Gene

Unigene Clusters for AGPAT1 Gene

1-acylglycerol-3-phosphate O-acyltransferase 1:
Representative Sequences:

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for AGPAT1

Primer Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for AGPAT1 Gene

No ASD Table

Relevant External Links for AGPAT1 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for AGPAT1 Gene

mRNA expression in normal human tissues for AGPAT1 Gene

Protein differential expression in normal tissues for AGPAT1 Gene

This gene is overexpressed in Bone (40.3).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for AGPAT1 Gene

SOURCE GeneReport for Unigene cluster for AGPAT1 Gene Hs.409230

mRNA Expression by UniProt/SwissProt for AGPAT1 Gene

Tissue specificity: Widely expressed. Expressed in adipose tissue and at high levels in testis and pancreas. Expressed at lower levels in tissues such as heart, brain, placenta, kidney, lung, spleen, thymus, prostate, ovary, intestine, colon, leukocyte and liver.
genes like me logo Genes that share expressions with AGPAT1: view

Expression partners for AGPAT1 Gene

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and mRNA differential expression in normal tissues for AGPAT1 Gene

Orthologs for AGPAT1 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for AGPAT1 Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia AGPAT1 35
  • 93.4 (n)
  • 97.53 (a)
  • 96 (a)
(Canis familiaris)
Mammalia AGPAT1 35
  • 93.4 (n)
  • 96.11 (a)
  • 95 (a)
(Mus musculus)
Mammalia Agpat1 35
  • 89.17 (n)
  • 92.5 (a)
Agpat1 16
Agpat1 36
  • 91 (a)
(Pan troglodytes)
Mammalia AGPAT1 35
  • 99.88 (n)
  • 100 (a)
  • 100 (a)
(Rattus norvegicus)
Mammalia Agpat1 35
  • 89.64 (n)
  • 93.93 (a)
(Monodelphis domestica)
Mammalia AGPAT1 36
  • 92 (a)
(Ornithorhynchus anatinus)
Mammalia AGPAT1 36
  • 71 (a)
(Gallus gallus)
Aves -- 36
  • 47 (a)
-- 36
  • 53 (a)
(Anolis carolinensis)
Reptilia AGPAT1 36
  • 61 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia agpat1 35
  • 65.75 (n)
  • 74.02 (a)
Str.17787 35
African clawed frog
(Xenopus laevis)
Amphibia Xl.15198 35
(Danio rerio)
Actinopterygii agpat2 35
  • 58.06 (n)
  • 54.1 (a)
fruit fly
(Drosophila melanogaster)
Insecta CG3812 37
  • 41 (a)
fu12 37
  • 33 (a)
CG3812 35
  • 50 (n)
  • 40.7 (a)
CG3812 36
  • 33 (a)
fu12 36
  • 30 (a)
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP002021 35
  • 51.22 (n)
  • 39.84 (a)
(Caenorhabditis elegans)
Secernentea T06E8.1 37
  • 41 (a)
acl-2 35
  • 48.6 (n)
  • 41.58 (a)
acl-1 36
  • 28 (a)
acl-2 36
  • 32 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes SLC1 36
  • 25 (a)
SLC1 38
SLC1 38
Species with no ortholog for AGPAT1:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for AGPAT1 Gene

Gene Tree for AGPAT1 (if available)
Gene Tree for AGPAT1 (if available)

Paralogs for AGPAT1 Gene

Paralogs for AGPAT1 Gene

Selected SIMAP similar genes for AGPAT1 Gene using alignment to 2 proteins:

genes like me logo Genes that share paralogs with AGPAT1: view

Variants for AGPAT1 Gene

Sequence variations from dbSNP and Humsavar for AGPAT1 Gene

SNP ID Clin Chr 06 pos Sequence Context AA Info Type MAF
rs204997 -- 32,176,234(-) CTGGG(C/G)CGGGG upstream-variant-2KB, intron-variant
rs408359 -- 32,174,106(-) aaaaa(C/T)GCCAG intron-variant
rs417035 -- 32,172,226(-) caagc(A/G)attct intron-variant
rs1061807 -- 32,169,061(-) GCAGT(C/T)TCCAC utr-variant-3-prime
rs1269839 -- 32,169,153(+) CCAAA(G/T)AGGAG utr-variant-3-prime

Structural Variations from Database of Genomic Variants (DGV) for AGPAT1 Gene

Variant ID Type Subtype PubMed ID
dgv1929e1 CNV Complex 17122850
nsv830629 CNV Loss 17160897
nsv884706 CNV Loss 21882294
nsv884707 CNV Loss 21882294
esv24778 CNV Loss 19812545

Relevant External Links for AGPAT1 Gene

HapMap Linkage Disequilibrium report

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for AGPAT1 Gene

Disorders for AGPAT1 Gene

(1) Novoseek inferred disease relationships for AGPAT1 Gene

Disease -log(P) Hits PubMed IDs
inflammation 0 2

Relevant External Links for AGPAT1

Genetic Association Database (GAD)
Human Genome Epidemiology (HuGE) Navigator
genes like me logo Genes that share disorders with AGPAT1: view

No data available for MalaCards , OMIM , UniProtKB/Swiss-Prot , University of Copenhagen DISEASES and Genatlas for AGPAT1 Gene

Publications for AGPAT1 Gene

  1. Characterization of a human lysophosphatidic acid acyltransferase that is encoded by a gene located in the class III region of the human major histocompatibility complex. (PMID: 9461603) Aguado B. … Campbell R.D. (J. Biol. Chem. 1998) 2 3 4 23
  2. Cloning and expression of two human lysophosphatidic acid acyltransferase cDNAs that enhance cytokine-induced signaling responses in cells. (PMID: 9212163) West J. … Leung D.W. (DNA Cell Biol. 1997) 3 4 23
  3. A human cDNA sequence with homology to non-mammalian lysophosphatidic acid acyltransferases. (PMID: 9291118) Stamps A.C. … Finnen M.J. (Biochem. J. 1997) 2 3 4
  4. The DNA sequence and analysis of human chromosome 6. (PMID: 14574404) Mungall A.J. … Beck S. (Nature 2003) 3 4
  5. Analysis of the gene-dense major histocompatibility complex class III region and its comparison to mouse. (PMID: 14656967) Xie T. … Hood L. (Genome Res. 2003) 3 4

Products for AGPAT1 Gene

Sources for AGPAT1 Gene

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