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Aliases for AGO4 Gene

Aliases for AGO4 Gene

  • Argonaute 4, RISC Catalytic Component 2 3 5
  • Eukaryotic Translation Initiation Factor 2C, 4 2 3
  • Argonaute RISC Catalytic Component 4 2 4
  • EIF2C4 3 4
  • Eukaryotic Translation Initiation Factor 2C 4 4
  • Protein Argonaute-4 3
  • Argonaute 4 2
  • Argonaute4 4
  • KIAA1567 4
  • EIF-2C 4 4
  • EIF2C 4 4
  • HAgo4 4

External Ids for AGO4 Gene

Previous HGNC Symbols for AGO4 Gene

  • EIF2C4

Previous GeneCards Identifiers for AGO4 Gene

  • GC01P035329
  • GC01P036274

Summaries for AGO4 Gene

Entrez Gene Summary for AGO4 Gene

  • This gene encodes a member of the Argonaute family of proteins which contain PAZ and PIWI domains and play an integral role in RNA interference and short-interfering-RNA-mediated gene silencing. This gene is located on chromosome 1 in a cluster of related family members. [provided by RefSeq, Mar 2017]

GeneCards Summary for AGO4 Gene

AGO4 (Argonaute 4, RISC Catalytic Component) is a Protein Coding gene. Among its related pathways are RET signaling and Mitotic Prophase. Gene Ontology (GO) annotations related to this gene include nucleic acid binding and double-stranded RNA binding. An important paralog of this gene is AGO1.

UniProtKB/Swiss-Prot for AGO4 Gene

  • Required for RNA-mediated gene silencing (RNAi). Binds to short RNAs such as microRNAs (miRNAs) and represses the translation of mRNAs which are complementary to them. Lacks endonuclease activity and does not appear to cleave target mRNAs. Also required for RNA-directed transcription and replication of the human hapatitis delta virus (HDV).

Additional gene information for AGO4 Gene

No data available for CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for AGO4 Gene

Genomics for AGO4 Gene

GeneHancer (GH) Regulatory Elements for AGO4 Gene

Promoters and enhancers for AGO4 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH01I035807 Promoter/Enhancer 2.2 EPDnew Ensembl ENCODE dbSUPER 550.8 +0.7 691 2.6 HDGF PKNOX1 FOXA2 ARID4B SIN3A ZNF2 YY1 ZNF766 GLIS2 KLF7 AGO4 SFPQ ZMYM1 AGO3 ZMYM6 ENSG00000230163 LOC653160 THRAP3 COL8A2 RPL5P4
GH01I035189 Promoter/Enhancer 2.3 EPDnew Ensembl ENCODE 21.5 -615.9 -615921 5 HDGF HNRNPUL1 PKNOX1 CLOCK FOXA2 SMAD1 ARID4B SIN3A DMAP1 ZNF2 SFPQ ZMYM1 LOC653160 ENSG00000230163 ZMYM6 LOC105378647 RPL5P4 AGO4 TMEM35B COL8A2
GH01I036159 Promoter/Enhancer 2.2 FANTOM5 Ensembl ENCODE dbSUPER 22.1 +356.1 356068 8.8 HDGF ARNT SIN3A FEZF1 ZNF2 YY1 ZNF766 ZNF213 ZNF143 SP3 CSF3R MAP7D1 THRAP3 AGO4 SFPQ STK40 RPL5P4 LOC105378647 COL8A2 EVA1B
GH01I036154 Promoter/Enhancer 2.3 EPDnew Ensembl ENCODE dbSUPER 13.3 +349.0 349037 4.5 PKNOX1 SMAD1 ARID4B SIN3A ZNF2 ZBTB7B POLR2B ZNF213 ZNF143 ZNF548 MAP7D1 TRAPPC3 SFPQ ZMYM4 AGO3 RPL5P4 THRAP3 COL8A2 EVA1B LOC105378647
GH01I035768 Promoter/Enhancer 2.3 EPDnew Ensembl ENCODE 10.8 -37.8 -37847 2.7 HDGF PKNOX1 SMAD1 ARID4B SIN3A DMAP1 YY1 POLR2B ZNF213 E2F8 CLSPN ENSG00000230163 THRAP3 ZMYM4 ZMYM1 LOC653160 AGO3 LOC105378647 AGO4 TRAPPC3
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around AGO4 on UCSC Golden Path with GeneCards custom track

Genomic Locations for AGO4 Gene

Genomic Locations for AGO4 Gene
chr1:35,807,630-35,857,890
(GRCh38/hg38)
Size:
50,261 bases
Orientation:
Plus strand
chr1:36,273,773-36,323,491
(GRCh37/hg19)

Genomic View for AGO4 Gene

Genes around AGO4 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
AGO4 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for AGO4 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for AGO4 Gene

Proteins for AGO4 Gene

  • Protein details for AGO4 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9HCK5-AGO4_HUMAN
    Recommended name:
    Protein argonaute-4
    Protein Accession:
    Q9HCK5
    Secondary Accessions:
    • A7MD27

    Protein attributes for AGO4 Gene

    Size:
    861 amino acids
    Molecular mass:
    97097 Da
    Quaternary structure:
    • Interacts with EIF4B, IMP8, PRMT5, TNRC6A and TNRC6B (PubMed:19167051). Interacts with ZFP36 (PubMed:15766526).
    SequenceCaution:
    • Sequence=BAB13393.1; Type=Erroneous initiation; Evidence={ECO:0000305};

neXtProt entry for AGO4 Gene

Post-translational modifications for AGO4 Gene

No Post-translational modifications

Other Protein References for AGO4 Gene

No data available for DME Specific Peptides for AGO4 Gene

Domains & Families for AGO4 Gene

Gene Families for AGO4 Gene

HGNC:
Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Suggested Antigen Peptide Sequences for AGO4 Gene

Graphical View of Domain Structure for InterPro Entry

Q9HCK5

UniProtKB/Swiss-Prot:

AGO4_HUMAN :
  • Belongs to the argonaute family. Ago subfamily.
Family:
  • Belongs to the argonaute family. Ago subfamily.
genes like me logo Genes that share domains with AGO4: view

Function for AGO4 Gene

Molecular function for AGO4 Gene

UniProtKB/Swiss-Prot Function:
Required for RNA-mediated gene silencing (RNAi). Binds to short RNAs such as microRNAs (miRNAs) and represses the translation of mRNAs which are complementary to them. Lacks endonuclease activity and does not appear to cleave target mRNAs. Also required for RNA-directed transcription and replication of the human hapatitis delta virus (HDV).

Phenotypes From GWAS Catalog for AGO4 Gene

Gene Ontology (GO) - Molecular Function for AGO4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003676 nucleic acid binding IEA --
GO:0003723 RNA binding IEA --
GO:0003725 double-stranded RNA binding IDA 19966796
GO:0003727 single-stranded RNA binding IDA 19966796
GO:0005515 protein binding IPI 15766526
genes like me logo Genes that share ontologies with AGO4: view
genes like me logo Genes that share phenotypes with AGO4: view

Animal Models for AGO4 Gene

MGI Knock Outs for AGO4:

miRNA for AGO4 Gene

miRTarBase miRNAs that target AGO4

Inhibitory RNA Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for AGO4 Gene

Localization for AGO4 Gene

Subcellular locations from UniProtKB/Swiss-Prot for AGO4 Gene

Cytoplasm, P-body.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for AGO4 gene
Compartment Confidence
nucleus 5
cytosol 5
plasma membrane 1
extracellular 1
mitochondrion 1
peroxisome 1
lysosome 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Cytosol (4)
  • Nucleoplasm (4)
  • Nuclear bodies (3)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for AGO4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000932 P-body IEA --
GO:0005634 nucleus IEA --
GO:0005654 nucleoplasm IDA --
GO:0005737 cytoplasm IEA,IDA 15260970
GO:0005829 cytosol TAS --
genes like me logo Genes that share ontologies with AGO4: view

Pathways & Interactions for AGO4 Gene

genes like me logo Genes that share pathways with AGO4: view

Pathways by source for AGO4 Gene

Gene Ontology (GO) - Biological Process for AGO4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006402 mRNA catabolic process IDA 18771919
GO:0006417 regulation of translation IEA --
GO:0007130 synaptonemal complex assembly IEA --
GO:0007140 male meiotic nuclear division IEA --
GO:0007223 Wnt signaling pathway, calcium modulating pathway TAS --
genes like me logo Genes that share ontologies with AGO4: view

No data available for SIGNOR curated interactions for AGO4 Gene

Drugs & Compounds for AGO4 Gene

No Compound Related Data Available

Transcripts for AGO4 Gene

Unigene Clusters for AGO4 Gene

Argonaute RISC catalytic component 4:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Alternative Splicing Database (ASD) splice patterns (SP) for AGO4 Gene

ExUns: 1 ^ 2 ^ 3a · 3b ^ 4 ^ 5a · 5b ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11 ^ 12 ^ 13 ^ 14 ^ 15 ^ 16a · 16b ^ 17a · 17b · 17c ^ 18 ^ 19 ^ 20
SP1: - -
SP2:
SP3: -
SP4: -
SP5:

Relevant External Links for AGO4 Gene

GeneLoc Exon Structure for
AGO4
ECgene alternative splicing isoforms for
AGO4

Expression for AGO4 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for AGO4 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for AGO4 Gene

This gene is overexpressed in Whole Blood (x4.8).

Protein differential expression in normal tissues from HIPED for AGO4 Gene

This gene is overexpressed in Tlymphocyte (20.1), Heart (12.8), Stomach (9.8), and Esophagus (7.5).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for AGO4 Gene



NURSA nuclear receptor signaling pathways regulating expression of AGO4 Gene:

AGO4

SOURCE GeneReport for Unigene cluster for AGO4 Gene:

Hs.744858

Evidence on tissue expression from TISSUES for AGO4 Gene

  • Nervous system(4.3)
genes like me logo Genes that share expression patterns with AGO4: view

Primer Products

No data available for Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for AGO4 Gene

Orthologs for AGO4 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for AGO4 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia EIF2C4 33 34
  • 100 (n)
oppossum
(Monodelphis domestica)
Mammalia AGO4 34
  • 100 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia AGO4 34
  • 100 (a)
OneToOne
dog
(Canis familiaris)
Mammalia AGO4 33 34
  • 94.42 (n)
cow
(Bos Taurus)
Mammalia AGO4 33 34
  • 94.39 (n)
mouse
(Mus musculus)
Mammalia Ago4 33 16 34
  • 91.79 (n)
chicken
(Gallus gallus)
Aves AGO4 33
  • 85.14 (n)
lizard
(Anolis carolinensis)
Reptilia AGO4 34
  • 98 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia LOC100495218 33
  • 81.66 (n)
zebrafish
(Danio rerio)
Actinopterygii ago4 33 34
  • 80.26 (n)
thale cress
(Arabidopsis thaliana)
eudicotyledons ZLL 33
  • 52.16 (n)
rice
(Oryza sativa)
Liliopsida Os02g0831600 33
  • 53.35 (n)
corn
(Zea mays)
Liliopsida Zm.10165 33
Species where no ortholog for AGO4 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for AGO4 Gene

ENSEMBL:
Gene Tree for AGO4 (if available)
TreeFam:
Gene Tree for AGO4 (if available)

Paralogs for AGO4 Gene

Paralogs for AGO4 Gene

(5) SIMAP similar genes for AGO4 Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with AGO4: view

Variants for AGO4 Gene

Sequence variations from dbSNP and Humsavar for AGO4 Gene

SNP ID Clin Chr 01 pos Variation AA Info Type
rs1000070288 -- 35,809,124(+) C/A genic_upstream_transcript_variant, intron_variant
rs1000076412 -- 35,807,956(+) G/T genic_upstream_transcript_variant, intron_variant, upstream_transcript_variant
rs1000143431 -- 35,854,541(+) T/C 3_prime_UTR_variant, genic_downstream_transcript_variant, intron_variant, non_coding_transcript_variant
rs1000215285 -- 35,850,075(+) C/G genic_downstream_transcript_variant, intron_variant
rs1000282909 -- 35,839,458(+) A/G genic_downstream_transcript_variant, intron_variant

Structural Variations from Database of Genomic Variants (DGV) for AGO4 Gene

Variant ID Type Subtype PubMed ID
nsv1130954 CNV deletion 24896259
nsv524683 CNV loss 19592680
nsv525430 CNV loss 19592680
nsv834680 CNV gain 17160897

Variation tolerance for AGO4 Gene

Residual Variation Intolerance Score: 4.21% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.68; 14.50% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for AGO4 Gene

Human Gene Mutation Database (HGMD)
AGO4
SNPedia medical, phenotypic, and genealogical associations of SNPs for
AGO4

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for AGO4 Gene

Disorders for AGO4 Gene

Additional Disease Information for AGO4

No disorders were found for AGO4 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for AGO4 Gene

Publications for AGO4 Gene

  1. Importin 8 is a gene silencing factor that targets argonaute proteins to distinct mRNAs. (PMID: 19167051) Weinmann L … Meister G (Cell 2009) 3 4 58
  2. Capped small RNAs and MOV10 in human hepatitis delta virus replication. (PMID: 18552826) Haussecker D … Kay MA (Nature structural & molecular biology 2008) 3 4 58
  3. Importance of translation and nonnucleolytic ago proteins for on-target RNA interference. (PMID: 18771919) Wu L … Belasco JG (Current biology : CB 2008) 3 4 58
  4. Involvement of microRNA in AU-rich element-mediated mRNA instability. (PMID: 15766526) Jing Q … Han J (Cell 2005) 3 4 58
  5. Human Argonaute2 mediates RNA cleavage targeted by miRNAs and siRNAs. (PMID: 15260970) Meister G … Tuschl T (Molecular cell 2004) 3 4 58

Products for AGO4 Gene

  • Addgene plasmids for AGO4

Sources for AGO4 Gene

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