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Aliases for AGO4 Gene

Aliases for AGO4 Gene

  • Argonaute 4, RISC Catalytic Component 2 3 5
  • Argonaute RISC Catalytic Component 4 2 3 4
  • Eukaryotic Translation Initiation Factor 2C, 4 2 3
  • Argonaute 4 2 3
  • Argonaute4 3 4
  • EIF-2C 4 3 4
  • EIF2C 4 3 4
  • EIF2C4 3 4
  • HAgo4 3 4
  • Eukaryotic Translation Initiation Factor 2C 4 4
  • KIAA1567 4

External Ids for AGO4 Gene

Previous HGNC Symbols for AGO4 Gene

  • EIF2C4

Previous GeneCards Identifiers for AGO4 Gene

  • GC01P035329
  • GC01P036274

Summaries for AGO4 Gene

Entrez Gene Summary for AGO4 Gene

  • This gene encodes a member of the Argonaute family of proteins which play a role in RNA interference. The encoded protein is highly basic containing PAZ and PIWI domains, and it may play a role in short-interfering-RNA-mediated gene silencing. This gene is located on chromosome 1 in a cluster of closely related family members including argonaute 3, and eukaryotic translation initiation factor 2C, 1. [provided by RefSeq, Jul 2008]

GeneCards Summary for AGO4 Gene

AGO4 (Argonaute 4, RISC Catalytic Component) is a Protein Coding gene. Among its related pathways are Gene Expression and PI3K events in ERBB4 signaling. GO annotations related to this gene include nucleic acid binding and double-stranded RNA binding. An important paralog of this gene is PIWIL4.

UniProtKB/Swiss-Prot for AGO4 Gene

  • Required for RNA-mediated gene silencing (RNAi). Binds to short RNAs such as microRNAs (miRNAs) and represses the translation of mRNAs which are complementary to them. Lacks endonuclease activity and does not appear to cleave target mRNAs. Also required for RNA-directed transcription and replication of the human hapatitis delta virus (HDV).

No data available for Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for AGO4 Gene

Genomics for AGO4 Gene

Regulatory Elements for AGO4 Gene

Enhancers for AGO4 Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around AGO4 on UCSC Golden Path with GeneCards custom track

Promoters for AGO4 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around AGO4 on UCSC Golden Path with GeneCards custom track

Genomic Location for AGO4 Gene

Chromosome:
1
Start:
35,807,630 bp from pter
End:
35,857,890 bp from pter
Size:
50,261 bases
Orientation:
Plus strand

Genomic View for AGO4 Gene

Genes around AGO4 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
AGO4 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for AGO4 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for AGO4 Gene

Proteins for AGO4 Gene

  • Protein details for AGO4 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9HCK5-AGO4_HUMAN
    Recommended name:
    Protein argonaute-4
    Protein Accession:
    Q9HCK5
    Secondary Accessions:
    • A7MD27

    Protein attributes for AGO4 Gene

    Size:
    861 amino acids
    Molecular mass:
    97097 Da
    Quaternary structure:
    • Interacts with EIF4B, IMP8, PRMT5, TNRC6A and TNRC6B.
    SequenceCaution:
    • Sequence=BAB13393.1; Type=Erroneous initiation; Evidence={ECO:0000305};

neXtProt entry for AGO4 Gene

Proteomics data for AGO4 Gene at MOPED

Post-translational modifications for AGO4 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for AGO4 Gene

ENSEMBL proteins:
REFSEQ proteins:

Antibody Products

  • Cell Signaling Technology (CST) Antibodies for AGO4 (AGO4)

No data available for DME Specific Peptides for AGO4 Gene

Domains & Families for AGO4 Gene

Gene Families for AGO4 Gene

Suggested Antigen Peptide Sequences for AGO4 Gene

Graphical View of Domain Structure for InterPro Entry

Q9HCK5

UniProtKB/Swiss-Prot:

AGO4_HUMAN :
  • Contains 1 PAZ domain.
  • Belongs to the argonaute family. Ago subfamily.
Domain:
  • Contains 1 PAZ domain.
  • Contains 1 Piwi domain.
Family:
  • Belongs to the argonaute family. Ago subfamily.
genes like me logo Genes that share domains with AGO4: view

Function for AGO4 Gene

Molecular function for AGO4 Gene

UniProtKB/Swiss-Prot Function:
Required for RNA-mediated gene silencing (RNAi). Binds to short RNAs such as microRNAs (miRNAs) and represses the translation of mRNAs which are complementary to them. Lacks endonuclease activity and does not appear to cleave target mRNAs. Also required for RNA-directed transcription and replication of the human hapatitis delta virus (HDV).
genes like me logo Genes that share phenotypes with AGO4: view

Animal Models for AGO4 Gene

MGI Knock Outs for AGO4:

Animal Model Products

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for AGO4 Gene

Localization for AGO4 Gene

Subcellular locations from UniProtKB/Swiss-Prot for AGO4 Gene

Cytoplasm, P-body.

Gene Ontology (GO) - Cellular Components for AGO4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0016020 membrane IDA 19946888
genes like me logo Genes that share ontologies with AGO4: view

No data available for Subcellular locations from COMPARTMENTS for AGO4 Gene

Pathways & Interactions for AGO4 Gene

genes like me logo Genes that share pathways with AGO4: view

Pathways by source for AGO4 Gene

Gene Ontology (GO) - Biological Process for AGO4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007173 epidermal growth factor receptor signaling pathway TAS --
GO:0007219 Notch signaling pathway TAS --
GO:0007223 Wnt signaling pathway, calcium modulating pathway TAS --
GO:0008543 fibroblast growth factor receptor signaling pathway TAS --
GO:0010501 RNA secondary structure unwinding IMP 22795694
genes like me logo Genes that share ontologies with AGO4: view

No data available for SIGNOR curated interactions for AGO4 Gene

Drugs & Compounds for AGO4 Gene

No Compound Related Data Available

Transcripts for AGO4 Gene

Unigene Clusters for AGO4 Gene

Argonaute RISC catalytic component 4:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for AGO4 Gene

ExUns: 1 ^ 2 ^ 3a · 3b ^ 4 ^ 5a · 5b ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11 ^ 12 ^ 13 ^ 14 ^ 15 ^ 16a · 16b ^ 17a · 17b · 17c ^ 18 ^ 19 ^ 20
SP1: - -
SP2:
SP3: -
SP4: -
SP5:

Relevant External Links for AGO4 Gene

GeneLoc Exon Structure for
AGO4
ECgene alternative splicing isoforms for
AGO4

Expression for AGO4 Gene

mRNA expression in normal human tissues for AGO4 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for AGO4 Gene

This gene is overexpressed in Whole Blood (x4.8).

Protein differential expression in normal tissues from HIPED for AGO4 Gene

This gene is overexpressed in Tlymphocyte (20.1), Heart (12.8), Stomach (9.8), and Esophagus (7.5).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for AGO4 Gene



SOURCE GeneReport for Unigene cluster for AGO4 Gene Hs.744858

genes like me logo Genes that share expression patterns with AGO4: view

Primer Products

No data available for mRNA Expression by UniProt/SwissProt and Protein tissue co-expression partners for AGO4 Gene

Orthologs for AGO4 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for AGO4 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia AGO4 35
  • 94.39 (n)
  • 99.54 (a)
AGO4 36
  • 99 (a)
OneToOne
dog
(Canis familiaris)
Mammalia AGO4 35
  • 94.42 (n)
  • 100 (a)
AGO4 36
  • 100 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Ago4 35
  • 91.79 (n)
  • 98.84 (a)
Ago4 16
Ago4 36
  • 99 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia EIF2C4 35
  • 100 (n)
  • 100 (a)
EIF2C4 36
  • 100 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia AGO4 36
  • 100 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia AGO4 36
  • 100 (a)
OneToOne
chicken
(Gallus gallus)
Aves AGO4 35
  • 85.14 (n)
  • 99.5 (a)
lizard
(Anolis carolinensis)
Reptilia AGO4 36
  • 98 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia LOC100495218 35
  • 81.66 (n)
  • 98.14 (a)
zebrafish
(Danio rerio)
Actinopterygii ago4 35
  • 80.26 (n)
  • 97.91 (a)
ago4 36
  • 96 (a)
OneToOne
thale cress
(Arabidopsis thaliana)
eudicotyledons ZLL 35
  • 52.16 (n)
  • 45.9 (a)
rice
(Oryza sativa)
Liliopsida Os02g0831600 35
  • 53.35 (n)
  • 47.57 (a)
corn
(Zea mays)
Liliopsida Zm.10165 35
Species with no ortholog for AGO4:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for AGO4 Gene

ENSEMBL:
Gene Tree for AGO4 (if available)
TreeFam:
Gene Tree for AGO4 (if available)

Paralogs for AGO4 Gene

Paralogs for AGO4 Gene

(5) SIMAP similar genes for AGO4 Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with AGO4: view

Variants for AGO4 Gene

Sequence variations from dbSNP and Humsavar for AGO4 Gene

SNP ID Clin Chr 01 pos Sequence Context AA Info Type
rs545577 -- 35,809,042(-) CTCTG(A/G)GACTA intron-variant
rs515346 -- 35,810,036(-) ACAAA(A/C)AAAAA intron-variant
rs636671 -- 35,827,609(+) AAACA(C/T)TTTCT intron-variant
rs582845 -- 35,848,598(+) TCCAA(A/G)GCATC intron-variant
rs620125 -- 35,819,712(-) tctgt(C/T)gaata intron-variant

Variation tolerance for AGO4 Gene

Residual Variation Intolerance Score: 4.21% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.68; 14.50% of all genes are more intolerant (likely to be disease-causing)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot , Structural Variations from Database of Genomic Variants (DGV) and Relevant External Links for AGO4 Gene

Disorders for AGO4 Gene

Relevant External Links for AGO4

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
AGO4

No disorders were found for AGO4 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for AGO4 Gene

Publications for AGO4 Gene

  1. Importin 8 is a gene silencing factor that targets argonaute proteins to distinct mRNAs. (PMID: 19167051) Weinmann L. … Meister G. (Cell 2009) 3 4 67
  2. Identification of eight members of the Argonaute family in the human genome. (PMID: 12906857) Sasaki T. … Shimizu N. (Genomics 2003) 2 3
  3. TRIM65 regulates microRNA activity by ubiquitination of TNRC6. (PMID: 24778252) Li S. … Dorf M.E. (Proc. Natl. Acad. Sci. U.S.A. 2014) 3
  4. Molecular dissection of human Argonaute proteins by DNA shuffling. (PMID: 23748378) SchA1rmann N. … Grimm D. (Nat. Struct. Mol. Biol. 2013) 3
  5. Slicing-independent RISC activation requires the argonaute PAZ domain. (PMID: 22795694) Gu S. … Kay M.A. (Curr. Biol. 2012) 3

Products for AGO4 Gene

Sources for AGO4 Gene

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