Aliases for AGO4 Gene
External Ids for AGO4 Gene
Previous HGNC Symbols for AGO4 Gene
Previous GeneCards Identifiers for AGO4 Gene
This gene encodes a member of the Argonaute family of proteins which play a role in RNA interference. The encoded protein is highly basic containing PAZ and PIWI domains, and it may play a role in short-interfering-RNA-mediated gene silencing. This gene is located on chromosome 1 in a cluster of closely related family members including argonaute 3, and eukaryotic translation initiation factor 2C, 1. [provided by RefSeq, Jul 2008]
GeneCards Summary for AGO4 Gene
AGO4 (Argonaute 4, RISC Catalytic Component) is a Protein Coding gene. Among its related pathways are Interleukin-3, 5 and GM-CSF signaling and Cellular Senescence. GO annotations related to this gene include nucleic acid binding and double-stranded RNA binding. An important paralog of this gene is AGO1.
UniProtKB/Swiss-Prot for AGO4 Gene
Required for RNA-mediated gene silencing (RNAi). Binds to short RNAs such as microRNAs (miRNAs) and represses the translation of mRNAs which are complementary to them. Lacks endonuclease activity and does not appear to cleave target mRNAs. Also required for RNA-directed transcription and replication of the human hapatitis delta virus (HDV).