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AGO4 Gene

protein-coding   GIFtS: 46
GCID: GC01P036274

Argonaute RISC Catalytic Component 4

(Previous names: eukaryotic translation initiation factor 2C, 4)
(Previous symbol: EIF2C4)
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Argonaute RISC Catalytic Component 41 2 3     hAgo42 3
EIF2C41 2 3 5     KIAA15673 5
Eukaryotic Translation Initiation Factor 2C, 41 2     argonaute42
Argonaute 41 2     Protein Argonaute-42
EIF-2C 42 3     Argonaute43
EIF2C 42 3     Eukaryotic Translation Initiation Factor 2C 43

External Ids:    HGNC: 184241   Entrez Gene: 1926702   Ensembl: ENSG000001346987   OMIM: 6073565   UniProtKB: Q9HCK53   

Export aliases for AGO4 gene to outside databases

Previous GC identifer: GC01P035329


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for AGO4 Gene:
This gene encodes a member of the Argonaute family of proteins which play a role in RNA interference. The encoded
protein is highly basic containing PAZ and PIWI domains, and it may play a role in short-interfering-RNA-mediated
gene silencing. This gene is located on chromosome 1 in a cluster of closely related family members including
argonaute 3, and eukaryotic translation initiation factor 2C, 1. (provided by RefSeq, Jul 2008)

GeneCards Summary for AGO4 Gene:
AGO4 (argonaute RISC catalytic component 4) is a protein-coding gene. Diseases associated with AGO4 include neuroblastoma, and hepatitis. GO annotations related to this gene include RNA binding. An important paralog of this gene is PIWIL4.

UniProtKB/Swiss-Prot: AGO4_HUMAN, Q9HCK5
Function: Required for RNA-mediated gene silencing (RNAi). Binds to short RNAs such as microRNAs (miRNAs) and
represses the translation of mRNAs which are complementary to them. Lacks endonuclease activity and does not
appear to cleave target mRNAs. Also required for RNA-directed transcription and replication of the human
hapatitis delta virus (HDV)




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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Regulatory elements:
   Search for regulatory transcription factor binding sites for AGO4
         Other transcription factors

Browse SwitchGear Promoter luciferase reporter plasmids
   Search Chromatin IP Primers for AGO4

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat AGO4


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 1p34   Ensembl cytogenetic band:  1p34.3   HGNC cytogenetic band: 1p34

AGO4 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
AGO4 gene location

GeneLoc information about chromosome 1         GeneLoc Exon Structure

GeneLoc location for GC01P036274:  view genomic region     (about GC identifiers)

Start:
36,273,773 bp from pter      End:
36,323,491 bp from pter
Size:
49,719 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
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UniProtKB/Swiss-Prot: AGO4_HUMAN, Q9HCK5 (See protein sequence)
Recommended Name: Protein argonaute-4  
Size: 861 amino acids; 97097 Da
Subunit: Interacts with EIF4B, IMP8, PRMT5, TNRC6A and TNRC6B
Sequence caution: Sequence=BAB13393.1; Type=Erroneous initiation;
Secondary accessions: A7MD27

Explore the universe of human proteins at neXtProt for AGO4: NX_Q9HCK5

Explore proteomics data for AGO4 at MOPED

Post-translational modifications: 

  • Ubiquitination2 at Lys356
  • Modification sites at PhosphoSitePlus

  • See AGO4 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_060099.2  
    ENSEMBL proteins: 
     ENSP00000362306  
    Reactome Protein details: Q9HCK5

    AGO4 Human Recombinant Protein Products:

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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    AGO: Argonaute/PIWI family

    5 InterPro protein domains:
     IPR014811 DUF1785
     IPR003165 Piwi
     IPR003100 PAZ_dom
     IPR028604 AGO4
     IPR012337 RNaseH-like_dom

    Graphical View of Domain Structure for InterPro Entry Q9HCK5

    ProtoNet protein and cluster: Q9HCK5

    2 Blocks protein domains:
    IPB003100 Argonaute and Dicer protein
    IPB003165 Stem cell self-renewal protein Piwi


    UniProtKB/Swiss-Prot: AGO4_HUMAN, Q9HCK5
    Similarity: Belongs to the argonaute family. Ago subfamily
    Similarity: Contains 1 PAZ domain
    Similarity: Contains 1 Piwi domain


    AGO4 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: AGO4_HUMAN, Q9HCK5
    Function: Required for RNA-mediated gene silencing (RNAi). Binds to short RNAs such as microRNAs (miRNAs) and
    represses the translation of mRNAs which are complementary to them. Lacks endonuclease activity and does not
    appear to cleave target mRNAs. Also required for RNA-directed transcription and replication of the human
    hapatitis delta virus (HDV)

         Gene Ontology (GO): 4 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003676nucleic acid binding ----
    GO:0003723RNA binding ----
    GO:0005515protein binding IPI19167051
    GO:0035198miRNA binding IEA--
         
    AGO4 for ontologies           About GeneDecksing


    Phenotypes:
         3 MGI mutant phenotypes (inferred from 1 allele(MGI details for Ago4):
     cellular  endocrine/exocrine gland  reproductive system 

    AGO4 for phenotypes           About GeneDecksing

    Animal Models:
         MGI mouse knock-out Ago4tm1.1Peco for AGO4

       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for AGO4
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    miRNA
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    miRTarBase miRNAs that target AGO4:
    hsa-mir-21-5p (MIRT031007), hsa-mir-335-5p (MIRT018390), hsa-mir-20a-5p (MIRT050568), hsa-let-7a-5p (MIRT003522), hsa-mir-484 (MIRT041657), hsa-mir-92a-3p (MIRT049549), hsa-mir-155-5p (MIRT020926)

    Block miRNA regulation of human, mouse, rat AGO4 using miScript Target Protectors
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    SwitchGear 3'UTR luciferase reporter plasmidAGO4 3' UTR sequence
    Inhib. RNA
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for AGO4


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    AGO4_HUMAN, Q9HCK5: Cytoplasm, P-body

    Gene Ontology (GO): 4 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000932cytoplasmic mRNA processing body IEA--
    GO:0005829cytosol TAS--
    GO:0016442RISC complex IEA--
    GO:0035068micro-ribonucleoprotein complex IEA--

    AGO4 for ontologies           About GeneDecksing


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for AGO4 About   (see all 14)  
    See pathways by source

    SuperPathSelected contained pathways About (see all per SuperPath)
    1Signaling by FGFR
    Signaling by FGFR0.91
    DAP12 interactions0.89
    Signaling by FGFR in disease0.91
    Signaling by PDGF0.87
    Downstream signaling of activated FGFR0.91
    Signaling by EGFR0.83
    Downstream signal transduction0.90
    Signaling by EGFR in Cancer0.82
    2PI-3K cascade
    PI3K/AKT activation0.93
    PI3K events in ERBB4 signaling0.88
    GAB1 signalosome0.93
    Role of LAT2/NTAL/LAB on calcium mobilization0.80
    PIP3 activates AKT signaling0.88
    Signaling by SCF-KIT0.72
    PI-3K cascade0.88
    Signaling by ERBB40.66
    3Regulatory RNA pathways
    MicroRNA (miRNA) Biogenesis0.88
    Post-transcriptional Silencing By Small RNAs0.00
    Regulatory RNA pathways0.88
    Small Interfering RNA (siRNA) Biogenesis0.00
    4Cellular Senescence
    Cellular Senescence0.81
    Oxidative Stress Induced Senescence0.64
    Cellular responses to stress0.81
    5beta-catenin independent WNT signaling
    beta-catenin independent WNT signaling0.79
    Ca2+ pathway0.43
    Signaling by Wnt0.79

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways


    1 Cell Signaling Technology (CST) Pathway for AGO4
        Translational Control

    Selected Reactome Pathways for AGO4 (see all 8)
        MicroRNA (miRNA) biogenesis
    Oncogene Induced Senescence
    Small interfering RNA (siRNA) biogenesis
    Oxidative Stress Induced Senescence
    Pre-NOTCH Transcription and Translation



    AGO4 for pathways           About GeneDecksing

        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for AGO4
    Interactions:

        Search GeneGlobe Interaction Network for AGO4

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for AGO4 (Q9HCK51, 3 ENSP000003623064) via UniProtKB, MINT, STRING, and/or I2D (see all 150)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    ENSG00000237724P081073, ENSP000004063594I2D: score=2 STRING: ENSP00000406359
    HSPA1AP081073, ENSP000003648024I2D: score=2 STRING: ENSP00000364802
    ENSG00000212866P081073I2D: score=2 
    ENSG00000215328P081073I2D: score=2 
    ENSG00000224501P081073I2D: score=2 
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    Gene Ontology (GO): Selected biological process terms (see all 10):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006402mRNA catabolic process IDA18771919
    GO:0007173epidermal growth factor receptor signaling pathway TAS--
    GO:0007219Notch signaling pathway TAS--
    GO:0008543fibroblast growth factor receptor signaling pathway TAS--
    GO:0010467gene expression TAS--

    AGO4 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for AGO4



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
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    REFSEQ mRNAs for AGO4 gene: 
    NM_017629.3  

    3 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000373210(uc001bzj.2) ENST00000488778 ENST00000496257
    miRNA
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    Inhib. RNA
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      QuantiFast Probe-based Assays in human, mouse, rat AGO4

    Selected AceView cDNA sequences (see all 88):

    CA419947 AB046787 BX464786 CK902316 AA504513 CK902315 BX116707 NM_017629 
    AA364304 AA912621 CR598503 BC016012 AI264318 AI669957 CD359384 AA291713 
    AA480126 AL831908 AA262593 BU620950 AI674879 BE045319 BX430990 BX440591 

    GeneLoc Exon Structure

    5 Alternative Splicing Database (ASD) splice patterns (SP) for AGO4    About this scheme

    ExUns: 1 ^ 2 ^ 3a · 3b ^ 4 ^ 5a · 5b ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11 ^ 12 ^ 13 ^ 14 ^ 15 ^ 16a · 16b ^ 17a · 17b · 17c ^ 18 ^ 19 ^ 20
    SP1:                                                                                                  -     -                                             
    SP2:                                                                                                                                                      
    SP3:        -                                                                                                                                             
    SP4:                                                                                                        -                                             
    SP5:                                                                                                                                                      


    ECgene alternative splicing isoforms for AGO4

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    AGO4 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: --
    AGO4 Expression
    About this image


    AGO4 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     
     Neural Tube (Nervous System)
             Primitive Spinal Cord
    AGO4 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    AGO4 Protein Expression
        Custom PCR Arrays for AGO4
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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for AGO4

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of eukaryotes.

    Orthologs for AGO4 gene from Selected species (see all 14)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Ago41 , 5 eukaryotic translation initiation factor 2C, 45
    argonaute RISC catalytic subunit 41
    91.79(n)1
    98.84(a)1
      4 (60.90 cM)5
    768501  NM_153177.31  NP_694817.21 
     1264895415 
    chicken
    (Gallus gallus)
    Aves AGO41 eukaryotic translation initiation factor 2C, 4 85.14(n)
    99.5(a)
      419629  NM_001039276.1  NP_001034365.1 
    lizard
    (Anolis carolinensis)
    Reptilia AGO46
    argonaute RISC catalytic component 4
    98(a)
    1 ↔ 1
    AAWZ02036231(17334-28010)
    African clawed frog
    (Xenopus laevis)
    Amphibia BJ090024.12   -- 80.33(n)    BJ090024.1 
    zebrafish
    (Danio rerio)
    Actinopterygii ago41 argonaute RISC catalytic component 4 80.26(n)
    97.91(a)
      100535764  NM_001252559.1  NP_001239488.1 
    thale cress
    (Arabidopsis thaliana)
    eudicotyledons ZLL1 ZLL 52.16(n)
    45.9(a)
      834403  NM_123748.2  NP_199194.1 
    rice
    (Oryza sativa)
    Liliopsida Os02g08316001 Os02g0831600 53.35(n)
    47.57(a)
      4331253  NM_001055156.1  NP_001048621.1 


    ENSEMBL Gene Tree for AGO4 (if available)
    TreeFam Gene Tree for AGO4 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for AGO4 gene
    PIWIL42  PIWIL22  AGO32  PIWIL12  AGO12  PIWIL32  AGO22  
    5 SIMAP similar genes for AGO4 using alignment to 1 protein entry:     AGO4_HUMAN:
    AGO1    AGO3    EIF2C2    AGO2    EIF2C3

    AGO4 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for AGO4 (see all 955)    About this table    
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 1 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1830605491,2
    --34389437(+) AAACCC/GCGTCT 1 -- int10--------
    rs1877372321,2
    C--34389475(+) CCGGGA/CGTGGT 1 -- int10--------
    rs1818352161,2
    --34391460(+) CCCCCC/TCCGCC 1 -- ut510--------
    rs1910359051,2
    --36272175(+) GCTCAA/CATGAA 1 -- us2k10--------
    rs1389871291,2
    --36272327(+) CTAGAA/GTGAGC 1 -- us2k10--------
    rs1422364521,2
    --36272416(+) GTCACC/TGGGAG 1 -- us2k10--------
    rs757402711,2
    F--36272482(+) TACATC/TGTATC 1 -- us2k11Minor allele frequency- T:0.05WA 118
    rs1833487001,2
    --36272512(+) AATTGC/TGAGAA 1 -- us2k10--------
    rs1874760821,2
    --36272665(+) ACTGCC/TTCTTG 1 -- us2k10--------
    rs1927239741,2
    --36272805(+) ATCCAA/GGAAAG 1 -- us2k10--------

    HapMap Linkage Disequilibrium report for AGO4 (36273773 - 36323491 bp)

    Structural Variations
          Database of Genomic Variants (DGV) variations for AGO4: --
    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing AGO4
    DNA2.0 Custom Variant and Variant Library Synthesis for AGO4

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 607356    OMIM disorders: --

    2 diseases for AGO4:    
    About MalaCards
    neuroblastoma    hepatitis


    AGO4 for disorders           About GeneDecksing


    Export disorders for AGO4 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for AGO4 gene, integrated from 10 sources (see all 24):
    (articles sorted by number of sources associating them with AGO4)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Importin 8 is a gene silencing factor that targets argonaute proteins to distinct mRNAs. (PubMed id 19167051)1, 2 Weinmann L.... Meister G. (Cell 2009)
    2. Importance of translation and nonnucleolytic ago proteins for on- target RNA interference. (PubMed id 18771919)1, 2 Wu L.... Belasco J.G. (Curr. Biol. 2008)
    3. Identification of eight members of the Argonaute family in the human genome. (PubMed id 12906857)1, 3 Sasaki T.... Shimizu N. (Genomics 2003)
    4. Prediction of the coding sequences of unidentified human genes. XVIII. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro. (PubMed id 10997877)1, 2 Nagase T.... Ohara O. (DNA Res. 2000)
    5. Molecular dissection of human Argonaute proteins by DNA shuffling. (PubMed id 23748378)1 SchA1rmann N....Grimm D. (amp 2013)
    6. Systematic and quantitative assessment of the ubiquitin-modified proteome. (PubMed id 21906983)1 Kim W....Gygi S.P. (Mol. Cell 2011)
    7. Interactions of pathological hallmark proteins: tubulin polymerization promoting protein/p25, beta-amyloid, and alpha-synuclein. (PubMed id 21832049)1 OlA!h J....OvA!di J. (J. Biol. Chem. 2011)
    8. Argonaute proteins: potential biomarkers for human colon cancer. (PubMed id 20146808)1 Li L....Li Y. (BMC Cancer 2010)
    9. Differential expression of Dicer and Argonaute genes during the differentiation of human neuroblastoma cells. (PubMed id 19393748)1 Potenza N....Russo A. (Cell Biol. Int. 2009)
    10. The C-terminal domains of human TNRC6A, TNRC6B, and TNRC6C silence bound transcripts independently of Argonaute proteins. (PubMed id 19383768)1 Lazzaretti D.... Izaurralde E. (RNA 2009)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 192670 HGNC: 18424 AceView: EIF2C4 Ensembl:ENSG00000134698 euGenes: HUgn192670
    ECgene: AGO4 H-InvDB: AGO4

    (According to HUGE)
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    HUGE: KIAA1567

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for AGO4 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for AGO4 gene:
    Search GeneIP for patents involving AGO4

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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