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Aliases for AGO3 Gene

Aliases for AGO3 Gene

  • Argonaute 3, RISC Catalytic Component 2 3 5
  • Argonaute RISC Catalytic Component 3 2 3 4
  • Eukaryotic Translation Initiation Factor 2C, 3 2 3
  • EIF2C3 3 4
  • HAgo3 3 4
  • Eukaryotic Translation Initiation Factor 2C 3 4
  • Protein Argonaute-3 3
  • Argonaute 3 2
  • Argonaute3 4
  • EIF-2C 3 4
  • EIF2C 3 4

External Ids for AGO3 Gene

Previous HGNC Symbols for AGO3 Gene

  • EIF2C3

Previous GeneCards Identifiers for AGO3 Gene

  • GC01P035452
  • GC01P036397
  • GC01P036399
  • GC01P036402
  • GC01P035930

Summaries for AGO3 Gene

Entrez Gene Summary for AGO3 Gene

  • This gene encodes a member of the Argonaute family of proteins which play a role in RNA interference. The encoded protein is highly basic, contains a PAZ domain and a PIWI domain, and may play a role in short-interfering-RNA-mediated gene silencing. This gene is located on chromosome 1 in a tandem cluster of closely related family members including argonaute 4 and eukaryotic translation initiation factor 2C, 1. Two transcript variants encoding distinct isoforms have been identified for this gene. [provided by RefSeq, Jul 2008]

GeneCards Summary for AGO3 Gene

AGO3 (Argonaute 3, RISC Catalytic Component) is a Protein Coding gene. Among its related pathways are RET signaling and Translational Control. GO annotations related to this gene include nucleic acid binding and RNA binding. An important paralog of this gene is AGO1.

UniProtKB/Swiss-Prot for AGO3 Gene

  • Required for RNA-mediated gene silencing (RNAi). Binds to short RNAs such as microRNAs (miRNAs) and represses the translation of mRNAs which are complementary to them. Lacks endonuclease activity and does not appear to cleave target mRNAs. Proposed to be involved in stabilization of small RNA derivates (riRNA) derived from processed RNA polymerase III-transcribed Alu repeats containing a DR2 retinoic acid response element (RARE) in stem cells and in the subsequent riRNA-dependent degradation of a subset of RNA polymerase II-transcribed coding mRNAs by recruiting a mRNA decapping complex involving EDC4.

Additional gene information for AGO3 Gene

No data available for CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for AGO3 Gene

Genomics for AGO3 Gene

Regulatory Elements for AGO3 Gene

Enhancers for AGO3 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH01H036154 1.4 ENCODE dbSUPER 84.6 +233.3 233265 4 PKNOX1 ARID4B SIN3A ZNF2 ZBTB7B ZNF143 ZNF548 FOS SP3 REST SFPQ ZMYM4 AGO3 RPL5P4 THRAP3 COL8A2 EVA1B MAP7D1 TRAPPC3 LOC105378647
GH01H035553 1.7 Ensembl ENCODE dbSUPER 42.8 -366.5 -366538 6 HDGF PKNOX1 FOXA2 MLX ARNT ARID4B SIN3A FEZF1 DMAP1 YBX1 ZMYM4 ZMYM6 SFPQ AGO3 ZMYM1 LOC653160 THRAP3 LOC100419802 ENSG00000232335 RPL12P45
GH01H036266 0.9 dbSUPER 75.3 +343.2 343237 0 ZNF493 ZFP64 ZEB1 ZNF121 ZNF23 ZNF302 ZNF354C KLF7 ZNF654 ZNF680 ZMYM4 AGO3 RPL5P4 COL8A2 THRAP3 EVA1B LOC105378647 TRAPPC3 AGO4 UBE2V2P4
GH01H035856 0.9 dbSUPER 62.6 -66.0 -65984 1 PKNOX1 ZNF493 ZFP64 RAD21 ZNF354C ZNF202 ZNF680 ZC3H11A REST ZNF623 ZMYM1 SFPQ ZMYM6 ZMYM4 LOC653160 AGO3 RPL5P4 COL8A2 THRAP3 EVA1B
GH01H036087 1.5 FANTOM5 ENCODE 30.9 +165.9 165850 2 ZFP64 DMAP1 YY1 SLC30A9 ZNF143 SP3 NFYC ZC3H11A MEF2D ZNF610 SFPQ ZMYM4 AGO3 THRAP3 STK40 LOC105378647 TRAPPC3 COL8A2 AGO1 TEKT2
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around AGO3 on UCSC Golden Path with GeneCards custom track

Genomic Location for AGO3 Gene

Chromosome:
1
Start:
35,923,403 bp from pter
End:
36,072,500 bp from pter
Size:
149,098 bases
Orientation:
Plus strand

Genomic View for AGO3 Gene

Genes around AGO3 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
AGO3 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for AGO3 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for AGO3 Gene

Proteins for AGO3 Gene

  • Protein details for AGO3 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9H9G7-AGO3_HUMAN
    Recommended name:
    Protein argonaute-3
    Protein Accession:
    Q9H9G7
    Secondary Accessions:
    • B1ALI0
    • Q5TA55
    • Q9H1U6

    Protein attributes for AGO3 Gene

    Size:
    860 amino acids
    Molecular mass:
    97360 Da
    Quaternary structure:
    • Interacts with EIF4B, IMP8, PRMT5 and TNRC6B. Interacts with APOBEC3F, APOBEC3G and APOBEC3H. Interacts with EDC4.

    Alternative splice isoforms for AGO3 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for AGO3 Gene

Post-translational modifications for AGO3 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for AGO3 Gene

Domains & Families for AGO3 Gene

Gene Families for AGO3 Gene

HGNC:
Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Graphical View of Domain Structure for InterPro Entry

Q9H9G7

UniProtKB/Swiss-Prot:

AGO3_HUMAN :
  • Belongs to the argonaute family. Ago subfamily.
Family:
  • Belongs to the argonaute family. Ago subfamily.
genes like me logo Genes that share domains with AGO3: view

Function for AGO3 Gene

Molecular function for AGO3 Gene

UniProtKB/Swiss-Prot Function:
Required for RNA-mediated gene silencing (RNAi). Binds to short RNAs such as microRNAs (miRNAs) and represses the translation of mRNAs which are complementary to them. Lacks endonuclease activity and does not appear to cleave target mRNAs. Proposed to be involved in stabilization of small RNA derivates (riRNA) derived from processed RNA polymerase III-transcribed Alu repeats containing a DR2 retinoic acid response element (RARE) in stem cells and in the subsequent riRNA-dependent degradation of a subset of RNA polymerase II-transcribed coding mRNAs by recruiting a mRNA decapping complex involving EDC4.

Phenotypes From GWAS Catalog for AGO3 Gene

Gene Ontology (GO) - Molecular Function for AGO3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003676 nucleic acid binding IEA --
GO:0003723 RNA binding IEA,IDA 22658674
GO:0003725 double-stranded RNA binding IDA 19966796
GO:0003727 single-stranded RNA binding IDA 19966796
GO:0003743 translation initiation factor activity IEA --
genes like me logo Genes that share ontologies with AGO3: view
genes like me logo Genes that share phenotypes with AGO3: view

Animal Models for AGO3 Gene

MGI Knock Outs for AGO3:
  • Ago3 tm1a(KOMP)Wtsi

Animal Model Products

CRISPR Products

miRNA for AGO3 Gene

miRTarBase miRNAs that target AGO3

Inhibitory RNA Products

Clone Products

  • Addgene plasmids for AGO3
  • Applied Biological Materials Clones for AGO3
  • Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for AGO3 Gene

Localization for AGO3 Gene

Subcellular locations from UniProtKB/Swiss-Prot for AGO3 Gene

Cytoplasm, P-body.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for AGO3 gene
Compartment Confidence
nucleus 5
cytosol 5
mitochondrion 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Cytoplasmic bodies (3)
  • Nucleoplasm (2)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for AGO3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000794 condensed nuclear chromosome IEA --
GO:0000932 P-body IEA,IDA --
GO:0005654 nucleoplasm IDA --
GO:0005737 cytoplasm IDA,IEA 15260970
GO:0005829 cytosol TAS --
genes like me logo Genes that share ontologies with AGO3: view

Pathways & Interactions for AGO3 Gene

genes like me logo Genes that share pathways with AGO3: view

Pathways by source for AGO3 Gene

Gene Ontology (GO) - Biological Process for AGO3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006402 mRNA catabolic process IDA 18771919
GO:0006413 translational initiation IEA --
GO:0006417 regulation of translation IEA --
GO:0007223 Wnt signaling pathway, calcium modulating pathway TAS --
GO:0010501 RNA secondary structure unwinding IMP 22795694
genes like me logo Genes that share ontologies with AGO3: view

No data available for SIGNOR curated interactions for AGO3 Gene

Drugs & Compounds for AGO3 Gene

No Compound Related Data Available

Transcripts for AGO3 Gene

Unigene Clusters for AGO3 Gene

Argonaute RISC catalytic component 3:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Clone Products

  • Addgene plasmids for AGO3
  • Applied Biological Materials Clones for AGO3
  • Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more

Alternative Splicing Database (ASD) splice patterns (SP) for AGO3 Gene

ExUns: 1 ^ 2a · 2b · 2c · 2d ^ 3a · 3b ^ 4 ^ 5 ^ 6 ^ 7 ^ 8a · 8b ^ 9 ^ 10 ^ 11 ^ 12 ^ 13 ^ 14 ^ 15 ^ 16 ^ 17 ^ 18 ^ 19 ^ 20 ^ 21a ·
SP1: - - - - -
SP2: - - - - - - -
SP3: - -
SP4: - -
SP5:
SP6:

ExUns: 21b ^ 22a · 22b ^ 23
SP1: -
SP2: -
SP3:
SP4:
SP5:
SP6:

Relevant External Links for AGO3 Gene

GeneLoc Exon Structure for
AGO3
ECgene alternative splicing isoforms for
AGO3

Expression for AGO3 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for AGO3 Gene

Protein differential expression in normal tissues from HIPED for AGO3 Gene

This gene is overexpressed in Uterus (6.7).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for AGO3 Gene



Protein tissue co-expression partners for AGO3 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of AGO3 Gene:

AGO3

SOURCE GeneReport for Unigene cluster for AGO3 Gene:

Hs.657659

Evidence on tissue expression from TISSUES for AGO3 Gene

  • Blood(4.2)
genes like me logo Genes that share expression patterns with AGO3: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for AGO3 Gene

Orthologs for AGO3 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for AGO3 Gene

Organism Taxonomy Gene Similarity Type Details
platypus
(Ornithorhynchus anatinus)
Mammalia AGO3 34
  • 100 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia EIF2C3 33 34
  • 99.77 (n)
oppossum
(Monodelphis domestica)
Mammalia AGO3 34
  • 99 (a)
OneToOne
dog
(Canis familiaris)
Mammalia AGO3 34 33
  • 95.85 (n)
OneToOne
cow
(Bos Taurus)
Mammalia AGO3 33 34
  • 95.16 (n)
mouse
(Mus musculus)
Mammalia Ago3 16 34 33
  • 92.6 (n)
rat
(Rattus norvegicus)
Mammalia Ago3 33
  • 91.43 (n)
chicken
(Gallus gallus)
Aves AGO3 33 34
  • 87.52 (n)
lizard
(Anolis carolinensis)
Reptilia AGO3 34
  • 99 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia ago3 33
  • 83.33 (n)
zebrafish
(Danio rerio)
Actinopterygii AGO3 (1 of 2) 34
  • 97 (a)
OneToMany
ago3b 34 33
  • 77.48 (n)
OneToMany
thale cress
(Arabidopsis thaliana)
eudicotyledons AGO1 33
  • 53.83 (n)
rice
(Oryza sativa)
Liliopsida Os02g0672200 33
  • 53.11 (n)
Os.10753 33
Species where no ortholog for AGO3 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for AGO3 Gene

ENSEMBL:
Gene Tree for AGO3 (if available)
TreeFam:
Gene Tree for AGO3 (if available)

Paralogs for AGO3 Gene

Paralogs for AGO3 Gene

(5) SIMAP similar genes for AGO3 Gene using alignment to 2 proteins:

genes like me logo Genes that share paralogs with AGO3: view

Variants for AGO3 Gene

Sequence variations from dbSNP and Humsavar for AGO3 Gene

SNP ID Clin Chr 01 pos Sequence Context AA Info Type
rs1000017230 -- 35,985,073(+) GATTG(C/G)TTGAG intron-variant
rs1000031916 -- 36,027,707(+) CCAGG(A/T)GGTGG intron-variant
rs1000037733 -- 35,943,696(+) CCTCC(A/G)GGGCT intron-variant
rs1000050388 -- 35,928,283(+) CCCAT(C/T)GTATT utr-variant-3-prime, utr-variant-5-prime
rs1000119444 -- 36,026,144(+) CACTC(C/T)GTCAC intron-variant

Structural Variations from Database of Genomic Variants (DGV) for AGO3 Gene

Variant ID Type Subtype PubMed ID
dgv149n100 CNV loss 25217958
esv3305175 CNV mobile element insertion 20981092
esv3309407 CNV mobile element insertion 20981092
esv3335594 CNV insertion 20981092
esv3371096 CNV insertion 20981092
esv3435241 CNV insertion 20981092
esv3585726 CNV gain 21293372
esv3585728 CNV loss 21293372
nsv1009033 CNV loss 25217958
nsv1009992 CNV gain+loss 25217958
nsv159158 CNV insertion 16902084
nsv518844 CNV loss 19592680
nsv998713 CNV gain 25217958

Variation tolerance for AGO3 Gene

Residual Variation Intolerance Score: 10.2% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.42; 9.12% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for AGO3 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
AGO3

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for AGO3 Gene

Disorders for AGO3 Gene

Relevant External Links for AGO3

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
AGO3

No disorders were found for AGO3 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for AGO3 Gene

Publications for AGO3 Gene

  1. DICER- and AGO3-dependent generation of retinoic acid-induced DR2 Alu RNAs regulates human stem cell proliferation. (PMID: 23064648) Hu Q … Rosenfeld MG (Nature structural & molecular biology 2012) 3 4 60
  2. HIV-1 replication and APOBEC3 antiviral activity are not regulated by P bodies. (PMID: 22915799) Phalora PK … Malim MH (Journal of virology 2012) 3 4 60
  3. Importin 8 is a gene silencing factor that targets argonaute proteins to distinct mRNAs. (PMID: 19167051) Weinmann L … Meister G (Cell 2009) 3 4 60
  4. Importance of translation and nonnucleolytic ago proteins for on-target RNA interference. (PMID: 18771919) Wu L … Belasco JG (Current biology : CB 2008) 3 4 60
  5. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 4 60

Products for AGO3 Gene

  • Addgene plasmids for AGO3

Sources for AGO3 Gene

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