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Aliases for AGO3 Gene

Aliases for AGO3 Gene

  • Argonaute RISC Catalytic Component 3 2 3 4
  • Eukaryotic Translation Initiation Factor 2C, 3 2 3
  • Argonaute 3 2 3
  • EIF2C3 3 4
  • HAgo3 3 4
  • Eukaryotic Translation Initiation Factor 2C 3 4
  • Argonaute3 4
  • EIF-2C 3 4
  • EIF2C 3 4

External Ids for AGO3 Gene

Previous HGNC Symbols for AGO3 Gene

  • EIF2C3

Previous GeneCards Identifiers for AGO3 Gene

  • GC01P035452
  • GC01P036397
  • GC01P036399
  • GC01P036402
  • GC01P035930

Summaries for AGO3 Gene

Entrez Gene Summary for AGO3 Gene

  • This gene encodes a member of the Argonaute family of proteins which play a role in RNA interference. The encoded protein is highly basic, contains a PAZ domain and a PIWI domain, and may play a role in short-interfering-RNA-mediated gene silencing. This gene is located on chromosome 1 in a tandem cluster of closely related family members including argonaute 4 and eukaryotic translation initiation factor 2C, 1. Two transcript variants encoding distinct isoforms have been identified for this gene. [provided by RefSeq, Jul 2008]

GeneCards Summary for AGO3 Gene

AGO3 (Argonaute RISC Catalytic Component 3) is a Protein Coding gene. Among its related pathways are PI3K/AKT Signaling in Cancer and Immune System. GO annotations related to this gene include nucleic acid binding and RNA binding. An important paralog of this gene is PIWIL4.

UniProtKB/Swiss-Prot for AGO3 Gene

  • Required for RNA-mediated gene silencing (RNAi). Binds to short RNAs such as microRNAs (miRNAs) and represses the translation of mRNAs which are complementary to them. Lacks endonuclease activity and does not appear to cleave target mRNAs. Proposed to be involved in stabilization of small RNA derivates (riRNA) derived from processed RNA polymerase III-transcribed Alu repeats containing a DR2 retinoic acid response element (RARE) in stem cells and in the subsequent riRNA-dependent degradation of a subset of RNA polymerase II-transcribed coding mRNAs by recruiting a mRNA decapping complex involving EDC4.

No data available for Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for AGO3 Gene

Genomics for AGO3 Gene

Genomic Location for AGO3 Gene

Chromosome:
1
Start:
35,923,403 bp from pter
End:
36,072,500 bp from pter
Size:
149,098 bases
Orientation:
Plus strand

Genomic View for AGO3 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for AGO3 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for AGO3 Gene

No data available for Regulatory Elements for AGO3 Gene

Proteins for AGO3 Gene

  • Protein details for AGO3 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9H9G7-AGO3_HUMAN
    Recommended name:
    Protein argonaute-3
    Protein Accession:
    Q9H9G7
    Secondary Accessions:
    • B1ALI0
    • Q5TA55
    • Q9H1U6

    Protein attributes for AGO3 Gene

    Size:
    860 amino acids
    Molecular mass:
    97360 Da
    Quaternary structure:
    • Interacts with EIF4B, IMP8, PRMT5 and TNRC6B. Interacts with APOBEC3F, APOBEC3G and APOBEC3H. Interacts with EDC4.

    Alternative splice isoforms for AGO3 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for AGO3 Gene

Proteomics data for AGO3 Gene at MOPED

Post-translational modifications for AGO3 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for AGO3 Gene

Antibody Products

  • Cell Signaling Technology (CST) Antibodies for AGO3 (AGO3)

No data available for DME Specific Peptides for AGO3 Gene

Domains & Families for AGO3 Gene

Gene Families for AGO3 Gene

Graphical View of Domain Structure for InterPro Entry

Q9H9G7

UniProtKB/Swiss-Prot:

AGO3_HUMAN :
  • Contains 1 PAZ domain.
  • Belongs to the argonaute family. Ago subfamily.
Domain:
  • Contains 1 PAZ domain.
  • Contains 1 Piwi domain.
Family:
  • Belongs to the argonaute family. Ago subfamily.
genes like me logo Genes that share domains with AGO3: view

Function for AGO3 Gene

Molecular function for AGO3 Gene

UniProtKB/Swiss-Prot Function:
Required for RNA-mediated gene silencing (RNAi). Binds to short RNAs such as microRNAs (miRNAs) and represses the translation of mRNAs which are complementary to them. Lacks endonuclease activity and does not appear to cleave target mRNAs. Proposed to be involved in stabilization of small RNA derivates (riRNA) derived from processed RNA polymerase III-transcribed Alu repeats containing a DR2 retinoic acid response element (RARE) in stem cells and in the subsequent riRNA-dependent degradation of a subset of RNA polymerase II-transcribed coding mRNAs by recruiting a mRNA decapping complex involving EDC4.

Gene Ontology (GO) - Molecular Function for AGO3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003676 nucleic acid binding --
GO:0003723 RNA binding --
GO:0003725 double-stranded RNA binding IDA 19966796
GO:0003727 single-stranded RNA binding IDA 19966796
GO:0003743 translation initiation factor activity --
genes like me logo Genes that share ontologies with AGO3: view
genes like me logo Genes that share phenotypes with AGO3: view

Animal Model Products

miRNA for AGO3 Gene

miRTarBase miRNAs that target AGO3

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for AGO3

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Animal Models , Transcription Factor Targets and HOMER Transcription for AGO3 Gene

Localization for AGO3 Gene

Subcellular locations from UniProtKB/Swiss-Prot for AGO3 Gene

Cytoplasm, P-body.

Gene Ontology (GO) - Cellular Components for AGO3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000932 cytoplasmic mRNA processing body IEA --
GO:0005737 cytoplasm IDA 15260970
GO:0005829 cytosol TAS --
GO:0016020 membrane IDA 19946888
GO:0016442 RISC complex IDA 15260970
genes like me logo Genes that share ontologies with AGO3: view

No data available for Subcellular locations from COMPARTMENTS for AGO3 Gene

Pathways & Interactions for AGO3 Gene

genes like me logo Genes that share pathways with AGO3: view

Pathways by source for AGO3 Gene

Gene Ontology (GO) - Biological Process for AGO3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006402 mRNA catabolic process IDA 18771919
GO:0006413 translational initiation --
GO:0007173 epidermal growth factor receptor signaling pathway TAS --
GO:0007219 Notch signaling pathway TAS --
GO:0008543 fibroblast growth factor receptor signaling pathway TAS --
genes like me logo Genes that share ontologies with AGO3: view

No data available for SIGNOR curated interactions for AGO3 Gene

Drugs & Compounds for AGO3 Gene

No Compound Related Data Available

Transcripts for AGO3 Gene

Unigene Clusters for AGO3 Gene

Argonaute RISC catalytic component 3:
Representative Sequences:

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for AGO3

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for AGO3 Gene

ExUns: 1 ^ 2a · 2b · 2c · 2d ^ 3a · 3b ^ 4 ^ 5 ^ 6 ^ 7 ^ 8a · 8b ^ 9 ^ 10 ^ 11 ^ 12 ^ 13 ^ 14 ^ 15 ^ 16 ^ 17 ^ 18 ^ 19 ^ 20 ^ 21a ·
SP1: - - - - -
SP2: - - - - - - -
SP3: - -
SP4: - -
SP5:
SP6:

ExUns: 21b ^ 22a · 22b ^ 23
SP1: -
SP2: -
SP3:
SP4:
SP5:
SP6:

Relevant External Links for AGO3 Gene

GeneLoc Exon Structure for
AGO3
ECgene alternative splicing isoforms for
AGO3

Expression for AGO3 Gene

mRNA expression in normal human tissues for AGO3 Gene

Protein differential expression in normal tissues from HIPED for AGO3 Gene

This gene is overexpressed in Uterus (6.7).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for AGO3 Gene



SOURCE GeneReport for Unigene cluster for AGO3 Gene Hs.657659

genes like me logo Genes that share expression patterns with AGO3: view

Protein tissue co-expression partners for AGO3 Gene

- Elite partner

Primer Products

  • QuantiTect SYBR Green Assays in human,mouse,rat
  • Pre-validated RT² qPCR Primer Assay in human,mouse,rat
  • QuantiFast Probe-based Assays in human,mouse,rat

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for AGO3 Gene

Orthologs for AGO3 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for AGO3 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia AGO3 35
  • 95.16 (n)
  • 98.84 (a)
AGO3 36
  • 100 (a)
OneToOne
dog
(Canis familiaris)
Mammalia AGO3 35
  • 95.85 (n)
  • 99.88 (a)
AGO3 36
  • 100 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Ago3 35
  • 92.6 (n)
  • 98.95 (a)
Ago3 16
Ago3 36
  • 99 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia EIF2C3 35
  • 99.77 (n)
  • 100 (a)
EIF2C3 36
  • 100 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Ago3 35
  • 91.43 (n)
  • 99.65 (a)
oppossum
(Monodelphis domestica)
Mammalia AGO3 36
  • 99 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia AGO3 36
  • 100 (a)
OneToOne
chicken
(Gallus gallus)
Aves AGO3 35
  • 87.52 (n)
  • 99.07 (a)
AGO3 36
  • 99 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia AGO3 36
  • 99 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia ago3 35
  • 83.33 (n)
  • 98.84 (a)
zebrafish
(Danio rerio)
Actinopterygii ago3b 35
  • 77.48 (n)
  • 95.12 (a)
AGO3 (1 of 2) 36
  • 97 (a)
OneToMany
ago3b 36
  • 95 (a)
OneToMany
thale cress
(Arabidopsis thaliana)
eudicotyledons AGO1 35
  • 53.83 (n)
  • 48.31 (a)
rice
(Oryza sativa)
Liliopsida Os.10753 35
Os02g0672200 35
  • 53.11 (n)
  • 48.81 (a)
Species with no ortholog for AGO3:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for AGO3 Gene

ENSEMBL:
Gene Tree for AGO3 (if available)
TreeFam:
Gene Tree for AGO3 (if available)

Paralogs for AGO3 Gene

Paralogs for AGO3 Gene

(5) SIMAP similar genes for AGO3 Gene using alignment to 2 proteins:

genes like me logo Genes that share paralogs with AGO3: view

Variants for AGO3 Gene

Sequence variations from dbSNP and Humsavar for AGO3 Gene

SNP ID Clin Chr 01 pos Sequence Context AA Info Type MAF
rs72661628 -- 35,940,946(+) AATCC(A/G)GTGGT intron-variant
rs72661631 -- 35,951,852(+) GGGGC(A/G)TATTT intron-variant
rs72661632 -- 35,955,114(+) AATCC(A/G)TGCTA intron-variant
rs72661633 -- 35,957,254(+) GGGAG(G/T)CTGAG intron-variant
rs72661635 -- 35,960,428(+) TGAAC(C/T)GTGAT intron-variant

Variation tolerance for AGO3 Gene

Residual Variation Intolerance Score: 10.16% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.42; 9.12% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for AGO3 Gene

HapMap Linkage Disequilibrium report
AGO3

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Structural Variations from Database of Genomic Variants (DGV) for AGO3 Gene

Disorders for AGO3 Gene

Relevant External Links for AGO3

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
AGO3
genes like me logo Genes that share disorders with AGO3: view

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for AGO3 Gene

Publications for AGO3 Gene

  1. Identification of eight members of the Argonaute family in the human genome. (PMID: 12906857) Sasaki T. … Shimizu N. (Genomics 2003) 2 67
  2. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin E.L. … Gygi S.P. (Cell 2015) 67
  3. TRIM65 regulates microRNA activity by ubiquitination of TNRC6. (PMID: 24778252) Li S. … Dorf M.E. (Proc. Natl. Acad. Sci. U.S.A. 2014) 67
  4. Molecular dissection of human Argonaute proteins by DNA shuffling. (PMID: 23748378) SchA1rmann N. … Grimm D. (Nat. Struct. Mol. Biol. 2013) 67
  5. Argonaute-3 activates the let-7a passenger strand microRNA. (PMID: 24100239) Winter J. … Diederichs S. (RNA Biol 2013) 67

Products for AGO3 Gene

Sources for AGO3 Gene

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