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AGO3 Gene

protein-coding   GIFtS: 48
GCID: GC01P036402

Argonaute RISC Catalytic Component 3

(Previous names: eukaryotic translation initiation factor 2C, 3)
(Previous symbol: EIF2C3)
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Argonaute RISC Catalytic Component 31 2 3     hAgo32 3
EIF2C31 2 3 5     argonaute32
Eukaryotic Translation Initiation Factor 2C, 31 2     Protein Argonaute-32
Argonaute 31 2     Argonaute33
EIF-2C 32 3     Eukaryotic Translation Initiation Factor 2C 33
EIF2C 32 3     

External Ids:    HGNC: 184211   Entrez Gene: 1926692   Ensembl: ENSG000001260707   OMIM: 6073555   UniProtKB: Q9H9G73   

Export aliases for AGO3 gene to outside databases

Previous GC identifers: GC01P035452 GC01P036397 GC01P036399


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for AGO3 Gene:
This gene encodes a member of the Argonaute family of proteins which play a role in RNA interference. The encoded
protein is highly basic, contains a PAZ domain and a PIWI domain, and may play a role in
short-interfering-RNA-mediated gene silencing. This gene is located on chromosome 1 in a tandem cluster of
closely related family members including argonaute 4 and eukaryotic translation initiation factor 2C, 1. Two
transcript variants encoding distinct isoforms have been identified for this gene. (provided by RefSeq, Jul 2008)

GeneCards Summary for AGO3 Gene:
AGO3 (argonaute RISC catalytic component 3) is a protein-coding gene. Diseases associated with AGO3 include neuroblastoma, and hiv-1. GO annotations related to this gene include RNA binding. An important paralog of this gene is PIWIL4.

UniProtKB/Swiss-Prot: AGO3_HUMAN, Q9H9G7
Function: Required for RNA-mediated gene silencing (RNAi). Binds to short RNAs such as microRNAs (miRNAs) and
represses the translation of mRNAs which are complementary to them. Lacks endonuclease activity and does not
appear to cleave target mRNAs. Proposed to be involved in stabilization of small RNA derivates (riRNA) derived
from processed RNA polymerase III-transcribed Alu repeats containing a DR2 retinoic acid response element (RARE)
in stem cells and in the subsequent riRNA-dependent degradation of a subset of RNA polymerase II-transcribed
coding mRNAs by recruiting a mRNA decapping complex involving EDC4




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence:
NC_000001.11  NT_032977.10  NC_018912.2  
Regulatory elements:
   Search for regulatory transcription factor binding sites for AGO3
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidAGO3 promoter sequence
   Search Chromatin IP Primers for AGO3

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat AGO3


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 1p34   Ensembl cytogenetic band:  1p34.3   HGNC cytogenetic band: 1p34

AGO3 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
AGO3 gene location

GeneLoc information about chromosome 1         GeneLoc Exon Structure

GeneLoc location for GC01P036402:  view genomic region     (about GC identifiers)

Start:
36,396,319 bp from pter      End:
36,538,101 bp from pter
Size:
141,783 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: AGO3_HUMAN, Q9H9G7 (See protein sequence)
Recommended Name: Protein argonaute-3  
Size: 860 amino acids; 97360 Da
Subunit: Interacts with EIF4B, IMP8, PRMT5 and TNRC6B. Interacts with APOBEC3F, APOBEC3G and APOBEC3H. Interacts
with EDC4
Secondary accessions: B1ALI0 Q5TA55 Q9H1U6
Alternative splicing: 2 isoforms:  Q9H9G7-1   Q9H9G7-2   

Explore the universe of human proteins at neXtProt for AGO3: NX_Q9H9G7

Explore proteomics data for AGO3 at MOPED

Post-translational modifications: 

  • Ubiquitination2 at Lys367
  • Modification sites at PhosphoSitePlus

  • See AGO3 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (2 alternative transcripts): 
    NP_079128.2  NP_803171.1  

    ENSEMBL proteins: 
     ENSP00000317425   ENSP00000362287   ENSP00000246314   ENSP00000380928  
    Reactome Protein details: Q9H9G7

    AGO3 Human Recombinant Protein Products:

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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    AGO: Argonaute/PIWI family

    5 InterPro protein domains:
     IPR014811 DUF1785
     IPR003165 Piwi
     IPR003100 PAZ_dom
     IPR028603 AGO3
     IPR012337 RNaseH-like_dom

    Graphical View of Domain Structure for InterPro Entry Q9H9G7

    ProtoNet protein and cluster: Q9H9G7

    2 Blocks protein domains:
    IPB003100 Argonaute and Dicer protein
    IPB003165 Stem cell self-renewal protein Piwi


    UniProtKB/Swiss-Prot: AGO3_HUMAN, Q9H9G7
    Similarity: Belongs to the argonaute family. Ago subfamily
    Similarity: Contains 1 PAZ domain
    Similarity: Contains 1 Piwi domain


    AGO3 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: AGO3_HUMAN, Q9H9G7
    Function: Required for RNA-mediated gene silencing (RNAi). Binds to short RNAs such as microRNAs (miRNAs) and
    represses the translation of mRNAs which are complementary to them. Lacks endonuclease activity and does not
    appear to cleave target mRNAs. Proposed to be involved in stabilization of small RNA derivates (riRNA) derived
    from processed RNA polymerase III-transcribed Alu repeats containing a DR2 retinoic acid response element (RARE)
    in stem cells and in the subsequent riRNA-dependent degradation of a subset of RNA polymerase II-transcribed
    coding mRNAs by recruiting a mRNA decapping complex involving EDC4

         Gene Ontology (GO): Selected molecular function terms (see all 6):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003676nucleic acid binding ----
    GO:0003723RNA binding ----
    GO:0003743translation initiation factor activity ----
    GO:0005515protein binding IPI19167051
    GO:0035198miRNA binding IEA--
         
    AGO3 for ontologies           About GeneDecksing


    Phenotypes:
         2 GenomeRNAi human phenotypes for AGO3:
     Decreased Tat-dependent transc  Decreased p24 protein expressi 

    Animal Models:
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    hsa-let-7b-5p (MIRT005037)

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    Inhib. RNA
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    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    AGO3_HUMAN, Q9H9G7: Cytoplasm, P-body

    Gene Ontology (GO): 4 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000932cytoplasmic mRNA processing body IEA--
    GO:0005829cytosol TAS--
    GO:0016442RISC complex IEA--
    GO:0035068micro-ribonucleoprotein complex IEA--

    AGO3 for ontologies           About GeneDecksing


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for AGO3 About   (see all 14)  
    See pathways by source

    SuperPathSelected contained pathways About (see all per SuperPath)
    1Signaling by FGFR
    Signaling by FGFR0.91
    DAP12 interactions0.89
    Signaling by FGFR in disease0.91
    Signaling by PDGF0.87
    Downstream signaling of activated FGFR0.91
    Signaling by EGFR0.83
    Downstream signal transduction0.90
    Signaling by EGFR in Cancer0.82
    2PI-3K cascade
    PI3K/AKT activation0.93
    PI3K events in ERBB4 signaling0.88
    GAB1 signalosome0.93
    Role of LAT2/NTAL/LAB on calcium mobilization0.80
    PIP3 activates AKT signaling0.88
    Signaling by SCF-KIT0.72
    PI-3K cascade0.88
    Signaling by ERBB40.66
    3Regulatory RNA pathways
    MicroRNA (miRNA) Biogenesis0.88
    Post-transcriptional Silencing By Small RNAs0.00
    Regulatory RNA pathways0.88
    Small Interfering RNA (siRNA) Biogenesis0.00
    4Cellular Senescence
    Cellular Senescence0.81
    Oxidative Stress Induced Senescence0.64
    Cellular responses to stress0.81
    5beta-catenin independent WNT signaling
    beta-catenin independent WNT signaling0.79
    Ca2+ pathway0.43
    Signaling by Wnt0.79

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways


    1 Cell Signaling Technology (CST) Pathway for AGO3
        Translational Control


    Selected Reactome Pathways for AGO3 (see all 8)
        MicroRNA (miRNA) biogenesis
    Oncogene Induced Senescence
    Small interfering RNA (siRNA) biogenesis
    Oxidative Stress Induced Senescence
    Pre-NOTCH Transcription and Translation



    AGO3 for pathways           About GeneDecksing

        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for AGO3
    Interactions:

        Search GeneGlobe Interaction Network for AGO3

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for AGO3 (Q9H9G71, 2, 3 ENSP000003622874) via UniProtKB, MINT, STRING, and/or I2D (see all 131)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    EEF1A1P681042, 3, ENSP000003300544MINT-6489217 I2D: score=2 STRING: ENSP00000330054
    HSPA9P386462, 3, ENSP000002971854MINT-6489217 I2D: score=2 STRING: ENSP00000297185
    RUVBL2Q9Y2302, 3, ENSP000002214134MINT-6489217 I2D: score=2 STRING: ENSP00000221413
    TAB1Q157502, 3, ENSP000002161604MINT-6489217 I2D: score=2 STRING: ENSP00000216160
    TNRC6BQ9UPQ92, 3, ENSP000003383714MINT-6489217 I2D: score=2 STRING: ENSP00000338371
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 11):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006402mRNA catabolic process IDA18771919
    GO:0007173epidermal growth factor receptor signaling pathway TAS--
    GO:0007219Notch signaling pathway TAS--
    GO:0008543fibroblast growth factor receptor signaling pathway TAS--
    GO:0010467gene expression TAS--

    AGO3 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for AGO3



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
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    REFSEQ mRNAs for AGO3 gene (2 alternative transcripts): 
    NM_024852.3  NM_177422.2  

    Unigene Cluster for AGO3:

    Argonaute RISC catalytic component 3
    Hs.657659  [show with all ESTs]
    Unigene Representative Sequence: NM_024852
    6 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000324350(uc001bzn.1) ENST00000373191(uc001bzp.3 uc001bzq.3)
    ENST00000246314 ENST00000491443 ENST00000471099 ENST00000397828
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    Additional mRNA sequence: 

    AK022827.1 AK027796.1 AK292870.1 AK302289.1 AK303929.1 BC025769.1 BC066888.1 BC144409.1 

    10 DOTS entries:

    DT.95367822  DT.40262462  DT.91759298  DT.97838275  DT.40195339  DT.91759297  DT.100655446  DT.102826730 
    DT.95280141  DT.99968728 

    Selected AceView cDNA sequences (see all 73):

    CA430277 NM_024852 W56196 BX111999 AI610252 AA320913 BC025769 AA814335 
    AA251591 BM794859 AW291767 NM_177422 BQ684784 BU629328 AW299698 AA251146 
    BC066888 CR616249 AA490849 AK022827 BQ446003 AI955621 BQ685694 BU151636 

    GeneLoc Exon Structure

    Selected Alternative Splicing Database (ASD) splice patterns (SP) for AGO3 (see all 6)    About this scheme

    ExUns: 1 ^ 2a · 2b · 2c · 2d ^ 3a · 3b ^ 4 ^ 5 ^ 6 ^ 7 ^ 8a · 8b ^ 9 ^ 10 ^ 11 ^ 12 ^ 13 ^ 14 ^ 15 ^ 16 ^ 17 ^ 18 ^ 19 ^ 20 ^ 21a ·
    SP1:                                                              -     -     -     -                                                                       -   
    SP2:                                            -           -     -     -     -     -                                                                       -   
    SP3:        -                                                     -                                                                                             
    SP4:                                                              -           -                                                                                 
    SP5:                                                                                                                                                            

    ExUns: 21b ^ 22a · 22b ^ 23
    SP1:              -         
    SP2:              -         
    SP3:                        
    SP4:                        
    SP5:                        


    ECgene alternative splicing isoforms for AGO3

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    AGO3 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: --
    AGO3 Expression
    About this image

    AGO3 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    AGO3 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.657659
        Custom PCR Arrays for AGO3
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    In Situ
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for AGO3

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of eukaryotes.

    Orthologs for AGO3 gene from Selected species (see all 13)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Ago31 , 5 eukaryotic translation initiation factor 2C, 35
    argonaute RISC catalytic subunit 31
    92.6(n)1
    98.95(a)1
      4 (60.39 cM)5
    2141501  NM_153402.21  NP_700451.21 
     1263317045 
    chicken
    (Gallus gallus)
    Aves AGO31 eukaryotic translation initiation factor 2C, 3 87.52(n)
    99.07(a)
      419628  NM_001030900.1  NP_001026071.1 
    lizard
    (Anolis carolinensis)
    Reptilia AGO36
    argonaute RISC catalytic component 3
    99(a)
    1 ↔ 1
    GL343488.1(563768-582862)
    tropical clawed frog
    (Xenopus tropicalis)
    Amphibia ago31 argonaute RISC catalytic component 3 83.33(n)
    98.84(a)
      100486574  XM_002936224.2  XP_002936270.2 
    zebrafish
    (Danio rerio)
    Actinopterygii ago3b1 argonaute RISC catalytic component 3b 77.48(n)
    95.12(a)
      568159  NM_001160028.1  NP_001153500.1 
    thale cress
    (Arabidopsis thaliana)
    eudicotyledons AGO11 AGO1 53.83(n)
    48.31(a)
      841262  NM_103737.3  NP_175274.1 
    rice
    (Oryza sativa)
    Liliopsida Os.107532 Oryza sativa (japonica cultivar-group) cDNA cloneJ more 71.47(n)    AK111996.1 


    ENSEMBL Gene Tree for AGO3 (if available)
    TreeFam Gene Tree for AGO3 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for AGO3 gene
    PIWIL42  PIWIL22  PIWIL12  AGO12  AGO42  PIWIL32  AGO22  
    5 SIMAP similar genes for AGO3 using alignment to 2 protein entries:     AGO3_HUMAN (see all proteins):
    EIF2C3    AGO4    AGO1    AGO2    EIF2C2

    AGO3 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for AGO3 (see all 2220)    About this table    
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 1 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs112638391,2
    C,F,A,H--36394725(+) CCCTTA/CAGAGC 2 -- us2k117Minor allele frequency- C:0.28NS EA NA WA 2224
    rs1464810991,2
    --36394742(+) AGTTGA/GGAATG 2 -- us2k10--------
    rs1409696091,2
    --36394984(+) TCAATA/GTTGAA 2 -- us2k10--------
    rs615883381,2
    C--36395022(+) CACTGA/TCACCA 2 -- us2k10--------
    rs1512094931,2
    --36395029(+) ACCATA/GTCTAA 2 -- us2k10--------
    rs6172541,2
    C,F--36395033(-) GACATT/GAGACA 2 -- us2k12Minor allele frequency- G:0.01MN CSA 186
    rs6176731,2
    C,F,A,H--36395115(-) GGGTCT/GTTTAT 2 -- us2k129Minor allele frequency- G:0.32EA NA MN NS CSA WA 3158
    rs118031621,2
    C,F,H--36395370(+) GTACTT/ATAAAA 2 -- us2k13Minor allele frequency- A:0.31WA CSA 122
    rs1882461131,2
    --36395408(+) CACTAA/GCATTT 2 -- us2k10--------
    rs1810644311,2
    --36395611(+) GATTAA/GAAAAA 2 -- us2k10--------

    HapMap Linkage Disequilibrium report for AGO3 (36396319 - 36538101 bp)

    Structural Variations
          Database of Genomic Variants (DGV) variations for AGO3: --
    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing AGO3
    DNA2.0 Custom Variant and Variant Library Synthesis for AGO3

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 607355    OMIM disorders: --

    2 diseases for AGO3:    
    About MalaCards
    neuroblastoma    hiv-1


    AGO3 for disorders           About GeneDecksing


    Export disorders for AGO3 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for AGO3 gene, integrated from 10 sources (see all 28):
    (articles sorted by number of sources associating them with AGO3)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. DICER- and AGO3-dependent generation of retinoic acid-induced DR2 Alu RNAs regulates human stem cell proliferation. (PubMed id 23064648)1, 2 Hu Q.... Rosenfeld M.G. (Nat. Struct. Mol. Biol. 2012)
    2. Importin 8 is a gene silencing factor that targets argonaute proteins to distinct mRNAs. (PubMed id 19167051)1, 2 Weinmann L.... Meister G. (Cell 2009)
    3. Importance of translation and nonnucleolytic ago proteins for on- target RNA interference. (PubMed id 18771919)1, 2 Wu L.... Belasco J.G. (Curr. Biol. 2008)
    4. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (Nat. Genet. 2004)
    5. Identification of eight members of the Argonaute family in the human genome. (PubMed id 12906857)1, 3 Sasaki T.... Shimizu N. (Genomics 2003)
    6. Molecular dissection of human Argonaute proteins by DNA shuffling. (PubMed id 23748378)1 SchA1rmann N....Grimm D. (amp 2013)
    7. Turning catalytically inactive human Argonaute proteins into active slicer enzymes. (PubMed id 23665583)1 Hauptmann J....Meister G. (amp 2013)
    8. HIV-1 replication and APOBEC3 antiviral activity are not regulated by P bodies. (PubMed id 22915799)2 Phalora P.K.... Malim M.H. (J. Virol. 2012)
    9. N-terminal acetylome analyses and functional insights of the N- terminal acetyltransferase NatB. (PubMed id 22814378)2 Van Damme P....Aldabe R. (Proc. Natl. Acad. Sci. U.S.A. 2012)
    10. Quantitative functions of Argonaute proteins in mammalian development. (PubMed id 22474261)1 Wang D....Yi R. (amp 2012)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 192669 HGNC: 18421 AceView: EIF2C3 Ensembl:ENSG00000126070 euGenes: HUgn192669
    ECgene: AGO3 H-InvDB: AGO3

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for AGO3 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for AGO3 gene:
    Search GeneIP for patents involving AGO3

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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