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Aliases for AGO2 Gene

Aliases for AGO2 Gene

  • Argonaute 2, RISC Catalytic Component 2 3 5
  • Argonaute RISC Catalytic Component 2 2 3 4
  • Cancer Susceptibility Candidate 7 (Non-Protein Coding) 2 3
  • Eukaryotic Translation Initiation Factor 2C, 2 2 3
  • PAZ Piwi Domain Protein 3 4
  • Protein Slicer 3 4
  • EIF2C2 3 4
  • PPD 3 4
  • Eukaryotic Translation Initiation Factor 2C 2 4
  • Long Intergenic Non-Protein Coding RNA 980 3
  • Cancer Susceptibility Candidate 7 3
  • Protein Argonaute-2 3
  • EC 3.1.26.n1 61
  • EC 3.1.26.n2 4
  • Argonaute 2 2
  • Argonaute2 4
  • LINC00980 3
  • EIF-2C 2 4
  • EIF2C 2 4
  • CASC7 3
  • HAgo2 4
  • Q10 3

External Ids for AGO2 Gene

Previous HGNC Symbols for AGO2 Gene

  • EIF2C2
  • CASC7

Previous GeneCards Identifiers for AGO2 Gene

  • GC08M141542
  • GC08M140531

Summaries for AGO2 Gene

Entrez Gene Summary for AGO2 Gene

  • This gene encodes a member of the Argonaute family of proteins which play a role in RNA interference. The encoded protein is highly basic, and contains a PAZ domain and a PIWI domain. It may interact with dicer1 and play a role in short-interfering-RNA-mediated gene silencing. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Sep 2009]

GeneCards Summary for AGO2 Gene

AGO2 (Argonaute 2, RISC Catalytic Component) is a Protein Coding gene. Diseases associated with AGO2 include Chromosome 18P Deletion Syndrome and Extraskeletal Mesenchymal Chondrosarcoma. Among its related pathways are Innate Immune System and GAB1 signalosome. GO annotations related to this gene include nucleic acid binding and RNA binding. An important paralog of this gene is AGO1.

UniProtKB/Swiss-Prot for AGO2 Gene

  • Required for RNA-mediated gene silencing (RNAi) by the RNA-induced silencing complex (RISC). The minimal RISC appears to include AGO2 bound to a short guide RNA such as a microRNA (miRNA) or short interfering RNA (siRNA). These guide RNAs direct RISC to complementary mRNAs that are targets for RISC-mediated gene silencing. The precise mechanism of gene silencing depends on the degree of complementarity between the miRNA or siRNA and its target. Binding of RISC to a perfectly complementary mRNA generally results in silencing due to endonucleolytic cleavage of the mRNA specifically by AGO2. Binding of RISC to a partially complementary mRNA results in silencing through inhibition of translation, and this is independent of endonuclease activity. May inhibit translation initiation by binding to the 7-methylguanosine cap, thereby preventing the recruitment of the translation initiation factor eIF4-E. May also inhibit translation initiation via interaction with EIF6, which itself binds to the 60S ribosomal subunit and prevents its association with the 40S ribosomal subunit. The inhibition of translational initiation leads to the accumulation of the affected mRNA in cytoplasmic processing bodies (P-bodies), where mRNA degradation may subsequently occur. In some cases RISC-mediated translational repression is also observed for miRNAs that perfectly match the 3 untranslated region (3-UTR). Can also up-regulate the translation of specific mRNAs under certain growth conditions. Binds to the AU element of the 3-UTR of the TNF (TNF-alpha) mRNA and up-regulates translation under conditions of serum starvation. Also required for transcriptional gene silencing (TGS), in which short RNAs known as antigene RNAs or agRNAs direct the transcriptional repression of complementary promoter regions.

Gene Wiki entry for AGO2 Gene

No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for AGO2 Gene

Genomics for AGO2 Gene

Regulatory Elements for AGO2 Gene

Enhancers for AGO2 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH08G140596 1.9 FANTOM5 Ensembl ENCODE dbSUPER 28.9 +44.0 44037 4.5 HDGF ATF1 WRNIP1 SIN3A FEZF1 FOS JUNB TBX21 SMARCA4 MYNN AGO2 CHRAC1 TRAPPC9 GC08P140597 ERICD
GH08G140618 1.3 ENCODE dbSUPER 26.3 +23.0 22996 1.7 HDGF ATF1 ARNT TCF12 ZNF766 GLIS2 ELK1 GATA2 REST MBD2 AGO2 CHRAC1 PTK2 ERICD GC08P140597
GH08G140585 1.9 FANTOM5 Ensembl ENCODE dbSUPER 16.9 +52.6 52578 9.2 FOXA2 PKNOX1 SIN3A GLIS2 GATA2 ZNF143 FOS ZNF263 SP3 JUNB AGO2 TRAPPC9 CHRAC1 PIR41172 ENSG00000279766
GH08G140594 1.3 FANTOM5 Ensembl ENCODE dbSUPER 23.7 +47.4 47369 0.7 CREB1 ATF2 AGO2 CHRAC1 GC08P140597 ENSG00000280326
GH08G140716 1.4 Ensembl ENCODE dbSUPER 17.3 -76.2 -76161 3.3 HDAC1 RB1 RAD21 TCF12 GATA2 EGR1 ZNF143 FOS DEK EGR2 AGO2 GC08M140724
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around AGO2 on UCSC Golden Path with GeneCards custom track

Genomic Location for AGO2 Gene

Chromosome:
8
Start:
140,520,156 bp from pter
End:
140,642,326 bp from pter
Size:
122,171 bases
Orientation:
Minus strand

Genomic View for AGO2 Gene

Genes around AGO2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
AGO2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for AGO2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for AGO2 Gene

Proteins for AGO2 Gene

  • Protein details for AGO2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9UKV8-AGO2_HUMAN
    Recommended name:
    Protein argonaute-2
    Protein Accession:
    Q9UKV8
    Secondary Accessions:
    • Q8TCZ5
    • Q8WV58
    • Q96ID1

    Protein attributes for AGO2 Gene

    Size:
    859 amino acids
    Molecular mass:
    97208 Da
    Cofactor:
    Name=Mg(2+); Xref=ChEBI:CHEBI:18420; Name=Mn(2+); Xref=ChEBI:CHEBI:29035;
    Quaternary structure:
    • Interacts with DICER1 through its Piwi domain and with TARBP2 during assembly of the RNA-induced silencing complex (RISC). Together, DICER1, AGO2 and TARBP2 constitute the trimeric RISC loading complex (RLC), or micro-RNA (miRNA) loading complex (miRLC). Within the RLC/miRLC, DICER1 and TARBP2 are required to process precursor miRNAs (pre-miRNAs) to mature miRNAs and then load them onto AGO2. AGO2 bound to the mature miRNA constitutes the minimal RISC and may subsequently dissociate from DICER1 and TARBP2. Note however that the term RISC has also been used to describe the trimeric RLC/miRLC. The formation of RISC complexes containing siRNAs rather than miRNAs appears to occur independently of DICER1. Interacts with AGO1. Also interacts with DDB1, DDX5, DDX6, DDX20, DHX30, DHX36, DDX47, DHX9, ELAVL, FXR1, GEMIN4, HNRNPF, IGF2BP1, ILF3, IMP8, MATR3, PABPC1, PRMT5, P4HA1, P4HB, RBM4, SART3, TNRC6A, TNRC6B, UPF1 and YBX1. Interacts with the P-body components DCP1A and XRN1. Associates with polysomes and messenger ribonucleoproteins (mNRPs). Interacts with RBM4; the interaction is modulated under stress-induced conditions, occurs under both cell proliferation and differentiation conditions and in an RNA- and phosphorylation-independent manner. Interacts with LIMD1, WTIP and AJUBA. Interacts with TRIM71. Interacts with APOBEC3G in an RNA-dependent manner. Interacts with APOBEC3A, APOBEC3C, APOBEC3F and APOBEC3H. Interacts with DICER1, TARBP2, EIF6, MOV10 and RPL7A (60S ribosome subunit); they form a large RNA-induced silencing complex (RISC) (PubMed:17507929). Interacts with FMR1 (PubMed:14703574). Interacts with ZFP36 (PubMed:15766526).
    SequenceCaution:
    • Sequence=AAH07633.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305}; Sequence=AAL76093.1; Type=Miscellaneous discrepancy; Note=cDNA contains a duplication of an internal sequence at the 5 end.; Evidence={ECO:0000305}; Sequence=BC125214; Type=Frameshift; Positions=450; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for AGO2 Gene

    Alternative splice isoforms for AGO2 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for AGO2 Gene

Selected DME Specific Peptides for AGO2 Gene

Q9UKV8:
  • NERVGKSGNIPAGTTVDTKITHP
  • QIFGDRKPVFDGRKNLYTAMPLPI
  • GRTIKLQANFFEMDIPKIDIYHYELDIKPEK
  • EFDFYLCSHAGIQGTSRPSHYHVLWDDNRFSSDELQIL
  • QALDVVMRHLPSMRYTPVGRSFFTASEGC
  • MTDVTGRVLQPPSILYGGR
  • KAIATPVQGVWDMRNKQFHTGIEIKVWAIACFAPQRQC
  • CVSLQALHDALSGRLP
  • CEVLDFKSIEEQQKPLTDSQRVKFTKEIKGLKVEITHC
  • NPLGGGREVWFGFHQSVRPSLWKMMLNIDVSATAFYKA

Post-translational modifications for AGO2 Gene

  • Hydroxylated. 4-hydroxylation appears to enhance protein stability but is not required for miRNA-binding or endonuclease activity.
  • Ubiquitination at Lys550
  • Modification sites at PhosphoSitePlus

Domains & Families for AGO2 Gene

Gene Families for AGO2 Gene

Suggested Antigen Peptide Sequences for AGO2 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q9UKV8

UniProtKB/Swiss-Prot:

AGO2_HUMAN :
  • The Piwi domain may perform RNA cleavage by a mechanism similar to that of RNase H. However, while RNase H utilizes a triad of Asp-Asp-Glu (DDE) for metal ion coordination, this protein appears to utilize a triad of Asp-Asp-His (DDH).
  • Belongs to the argonaute family. Ago subfamily.
Domain:
  • The Piwi domain may perform RNA cleavage by a mechanism similar to that of RNase H. However, while RNase H utilizes a triad of Asp-Asp-Glu (DDE) for metal ion coordination, this protein appears to utilize a triad of Asp-Asp-His (DDH).
Family:
  • Belongs to the argonaute family. Ago subfamily.
genes like me logo Genes that share domains with AGO2: view

Function for AGO2 Gene

Molecular function for AGO2 Gene

UniProtKB/Swiss-Prot BiophysicochemicalProperties:
Kinetic parameters: KM=1.1 nM for a synthetic 21-nucleotide single-stranded RNA {ECO:0000269 PubMed:15105377, ECO:0000269 PubMed:15800637};
UniProtKB/Swiss-Prot CatalyticActivity:
Endonucleolytic cleavage to 5-phosphomonoester.
UniProtKB/Swiss-Prot EnzymeRegulation:
Inhibited by EDTA.
UniProtKB/Swiss-Prot Function:
Required for RNA-mediated gene silencing (RNAi) by the RNA-induced silencing complex (RISC). The minimal RISC appears to include AGO2 bound to a short guide RNA such as a microRNA (miRNA) or short interfering RNA (siRNA). These guide RNAs direct RISC to complementary mRNAs that are targets for RISC-mediated gene silencing. The precise mechanism of gene silencing depends on the degree of complementarity between the miRNA or siRNA and its target. Binding of RISC to a perfectly complementary mRNA generally results in silencing due to endonucleolytic cleavage of the mRNA specifically by AGO2. Binding of RISC to a partially complementary mRNA results in silencing through inhibition of translation, and this is independent of endonuclease activity. May inhibit translation initiation by binding to the 7-methylguanosine cap, thereby preventing the recruitment of the translation initiation factor eIF4-E. May also inhibit translation initiation via interaction with EIF6, which itself binds to the 60S ribosomal subunit and prevents its association with the 40S ribosomal subunit. The inhibition of translational initiation leads to the accumulation of the affected mRNA in cytoplasmic processing bodies (P-bodies), where mRNA degradation may subsequently occur. In some cases RISC-mediated translational repression is also observed for miRNAs that perfectly match the 3 untranslated region (3-UTR). Can also up-regulate the translation of specific mRNAs under certain growth conditions. Binds to the AU element of the 3-UTR of the TNF (TNF-alpha) mRNA and up-regulates translation under conditions of serum starvation. Also required for transcriptional gene silencing (TGS), in which short RNAs known as antigene RNAs or agRNAs direct the transcriptional repression of complementary promoter regions.

Enzyme Numbers (IUBMB) for AGO2 Gene

Gene Ontology (GO) - Molecular Function for AGO2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000340 RNA 7-methylguanosine cap binding IDA 17524464
GO:0000993 RNA polymerase II core binding IDA 25336585
GO:0001047 core promoter binding IMP 25336585
GO:0003676 nucleic acid binding IEA --
GO:0003723 RNA binding IDA,IEA 22658674
genes like me logo Genes that share ontologies with AGO2: view
genes like me logo Genes that share phenotypes with AGO2: view

Animal Models for AGO2 Gene

MGI Knock Outs for AGO2:

Animal Model Products

CRISPR Products

miRNA for AGO2 Gene

miRTarBase miRNAs that target AGO2

Inhibitory RNA Products

Clone Products

  • Addgene plasmids for AGO2

No data available for Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for AGO2 Gene

Localization for AGO2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for AGO2 Gene

Cytoplasm, P-body. Nucleus. Note=Translational repression of mRNAs results in their recruitment to P-bodies. Translocation to the nucleus requires IMP8.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for AGO2 gene
Compartment Confidence
nucleus 5
cytosol 4
extracellular 1
cytoskeleton 1
mitochondrion 1
endosome 1

Gene Ontology (GO) - Cellular Components for AGO2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000932 P-body IDA,IEA 20616046
GO:0005634 nucleus IC 25336585
GO:0005654 nucleoplasm TAS --
GO:0005737 cytoplasm IDA 15260970
GO:0005829 cytosol TAS --
genes like me logo Genes that share ontologies with AGO2: view

Pathways & Interactions for AGO2 Gene

genes like me logo Genes that share pathways with AGO2: view

Pathways by source for AGO2 Gene

1 Cell Signaling Technology pathway for AGO2 Gene
3 Qiagen pathways for AGO2 Gene

Gene Ontology (GO) - Biological Process for AGO2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006351 transcription, DNA-templated IEA --
GO:0006355 regulation of transcription, DNA-templated IEA --
GO:0006412 translation NAS 10534406
GO:0006413 translational initiation IEA --
GO:0006417 regulation of translation IEA --
genes like me logo Genes that share ontologies with AGO2: view

No data available for SIGNOR curated interactions for AGO2 Gene

Drugs & Compounds for AGO2 Gene

No Compound Related Data Available

Transcripts for AGO2 Gene

Unigene Clusters for AGO2 Gene

Argonaute RISC catalytic component 2:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Clone Products

  • Addgene plasmids for AGO2

Alternative Splicing Database (ASD) splice patterns (SP) for AGO2 Gene

No ASD Table

Relevant External Links for AGO2 Gene

GeneLoc Exon Structure for
AGO2
ECgene alternative splicing isoforms for
AGO2

Expression for AGO2 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for AGO2 Gene

mRNA differential expression in normal tissues according to GTEx for AGO2 Gene

This gene is overexpressed in Whole Blood (x7.5) and Muscle - Skeletal (x4.3).

Protein differential expression in normal tissues from HIPED for AGO2 Gene

This gene is overexpressed in Bone marrow stromal cell (10.1) and Lymph node (9.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for AGO2 Gene



Protein tissue co-expression partners for AGO2 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of AGO2 Gene:

AGO2

SOURCE GeneReport for Unigene cluster for AGO2 Gene:

Hs.743313

Evidence on tissue expression from TISSUES for AGO2 Gene

  • Nervous system(4.5)
  • Eye(4.3)
  • Bone marrow(2.5)
  • Blood(2.3)
  • Heart(2.1)
  • Liver(2)
  • Skin(2)
genes like me logo Genes that share expression patterns with AGO2: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for AGO2 Gene

Orthologs for AGO2 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for AGO2 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia EIF2C2 34 35
  • 99.59 (n)
oppossum
(Monodelphis domestica)
Mammalia AGO2 35
  • 98 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia AGO2 35
  • 98 (a)
OneToOne
dog
(Canis familiaris)
Mammalia AGO2 34 35
  • 92.58 (n)
cow
(Bos Taurus)
Mammalia EIF2C2 34 35
  • 92.48 (n)
mouse
(Mus musculus)
Mammalia Ago2 34 16 35
  • 90.78 (n)
rat
(Rattus norvegicus)
Mammalia Ago2 34
  • 90.14 (n)
chicken
(Gallus gallus)
Aves AGO2 35
  • 98 (a)
OneToOne
LOC100858102 34
  • 81.71 (n)
lizard
(Anolis carolinensis)
Reptilia AGO2 35
  • 97 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia ago2 34
  • 79.96 (n)
Str.15011 34
zebrafish
(Danio rerio)
Actinopterygii CU929240.1 35
  • 90 (a)
OneToOne
LOC570630 34
  • 79.94 (n)
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP011717 34
  • 68.98 (n)
fruit fly
(Drosophila melanogaster)
Insecta AGO1 34
  • 67.5 (n)
worm
(Caenorhabditis elegans)
Secernentea alg-1 34
  • 62.53 (n)
thale cress
(Arabidopsis thaliana)
eudicotyledons AGO5 34
  • 49.82 (n)
soybean
(Glycine max)
eudicotyledons Gma.5747 34
Species where no ortholog for AGO2 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for AGO2 Gene

ENSEMBL:
Gene Tree for AGO2 (if available)
TreeFam:
Gene Tree for AGO2 (if available)

Paralogs for AGO2 Gene

Paralogs for AGO2 Gene

(5) SIMAP similar genes for AGO2 Gene using alignment to 3 proteins:

genes like me logo Genes that share paralogs with AGO2: view

Variants for AGO2 Gene

Sequence variations from dbSNP and Humsavar for AGO2 Gene

SNP ID Clin Chr 08 pos Sequence Context AA Info Type
rs1000003326 -- 140,563,853(+) CATGC(C/T)CAGCT intron-variant
rs1000010494 -- 140,624,471(+) AGCTC(C/T)GGCCA intron-variant, utr-variant-5-prime
rs1000026264 -- 140,624,227(+) TGGAG(C/T)CCTGC intron-variant, utr-variant-5-prime
rs1000061020 -- 140,569,289(+) GAGCT(A/G)TGGGT intron-variant
rs1000091882 -- 140,569,563(+) CCAGG(A/G)AGCTG intron-variant

Structural Variations from Database of Genomic Variants (DGV) for AGO2 Gene

Variant ID Type Subtype PubMed ID
esv1712972 CNV deletion 17803354
esv24351 CNV loss 19812545
esv2539959 CNV deletion 19546169
esv2737756 CNV deletion 23290073
esv2737758 CNV deletion 23290073
nsv1016282 CNV gain 25217958
nsv1025478 CNV gain 25217958
nsv1115144 CNV deletion 24896259
nsv1126125 CNV deletion 24896259
nsv1137621 CNV deletion 24896259
nsv1144237 CNV deletion 24896259
nsv465952 CNV loss 19166990
nsv512075 CNV loss 21212237
nsv526444 CNV gain 19592680
nsv612568 CNV gain 21841781
nsv612569 CNV loss 21841781
nsv612570 CNV gain 21841781
nsv6427 CNV insertion 18451855
nsv824748 CNV gain 20364138

Variation tolerance for AGO2 Gene

Residual Variation Intolerance Score: 2.86% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.13; 2.90% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for AGO2 Gene

Human Gene Mutation Database (HGMD)
AGO2
SNPedia medical, phenotypic, and genealogical associations of SNPs for
AGO2

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for AGO2 Gene

Disorders for AGO2 Gene

MalaCards: The human disease database

(11) MalaCards diseases for AGO2 Gene - From: DISEASES and GeneCards

Disorder Aliases PubMed IDs
chromosome 18p deletion syndrome
  • 18p- syndrome
extraskeletal mesenchymal chondrosarcoma
  • mesenchymal extraosseous chondrosarcoma
gum cancer
  • malignant gingival tumor
patau syndrome
  • d1 trisomy
18p deletion syndrome
  • chromosome 18p deletion syndrome
- elite association - COSMIC cancer census association via MalaCards
Search AGO2 in MalaCards View complete list of genes associated with diseases

Relevant External Links for AGO2

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
AGO2
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
AGO2
genes like me logo Genes that share disorders with AGO2: view

No data available for UniProtKB/Swiss-Prot and Genatlas for AGO2 Gene

Publications for AGO2 Gene

  1. In vitro reconstitution of the human RISC-loading complex. (PMID: 18178619) MacRae I.J. … Doudna J.A. (Proc. Natl. Acad. Sci. U.S.A. 2008) 3 4 22 64
  2. Translation repression in human cells by microRNA-induced gene silencing requires RCK/p54. (PMID: 16756390) Chu C.-Y. … Rana T.M. (PLoS Biol. 2006) 3 4 22 64
  3. A human, ATP-independent, RISC assembly machine fueled by pre- miRNA. (PMID: 16357216) Maniataki E. … Mourelatos Z. (Genes Dev. 2005) 3 4 22 64
  4. Characterization of the interactions between mammalian PAZ PIWI domain proteins and Dicer. (PMID: 14749716) Tahbaz N. … Hobman T.C. (EMBO Rep. 2004) 3 4 22 64
  5. Human eukaryotic initiation factor EIF2C1 gene: cDNA sequence, genomic organization, localization to chromosomal bands 1p34-p35, and expression. (PMID: 10534406) Koesters R. … Briner J. (Genomics 1999) 2 3 4 64

Products for AGO2 Gene

  • Addgene plasmids for AGO2

Sources for AGO2 Gene

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