Set Analyses:
Advanced Search

Advanced Search

 
Search By
Section (entire)
for


 



AGO1 Gene

protein-coding   GIFtS: 50
GCID: GC01P036336

Argonaute RISC Catalytic Component 1

(Previous names: eukaryotic translation initiation factor 2C, 1)
(Previous symbol: EIF2C1)
  Try our

disease database 

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

TryGeneCards Plus

Aliases
Argonaute RISC Catalytic Component 11 2 3     EIF2C2 5
EIF2C11 2 3 5     GERP952 5
Eukaryotic Translation Initiation Factor 2C, 11 2     Q992
Argonaute 11 2     argonaute12
Putative RNA-Binding Protein Q992 3     Golgi Endoplasmic Reticulum Protein 95 KDa2
EIF-2C 12 3     Protein Argonaute-12
EIF2C 12 3     Argonaute13
hAgo12 3     Eukaryotic Translation Initiation Factor 2C 13

External Ids:    HGNC: 32621   Entrez Gene: 265232   Ensembl: ENSG000000928477   OMIM: 6062285   UniProtKB: Q9UL183   

Export aliases for AGO1 gene to outside databases


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

TryGeneCards Plus

Entrez Gene summary for AGO1 Gene:
This gene encodes a member of the Argonaute family of proteins which play a role in RNA interference. The encoded
protein is highly basic, and contains a PAZ domain and a PIWI domain. It may interact with dicer1 and play a role
in short-interfering-RNA-mediated gene silencing. This gene is located on chromosome 1 in a cluster of closely
related family members including argonaute 3, and argonaute 4. (provided by RefSeq, Jul 2008)

GeneCards Summary for AGO1 Gene:
AGO1 (argonaute RISC catalytic component 1) is a protein-coding gene. GO annotations related to this gene include RNA binding. An important paralog of this gene is PIWIL4.

UniProtKB/Swiss-Prot: AGO1_HUMAN, Q9UL18
Function: Required for RNA-mediated gene silencing (RNAi). Binds to short RNAs such as microRNAs (miRNAs) or short
interfering RNAs (siRNAs), and represses the translation of mRNAs which are complementary to them. Lacks
endonuclease activity and does not appear to cleave target mRNAs. Also required for transcriptional gene
silencing (TGS) of promoter regions which are complementary to bound short antigene RNAs (agRNAs)

Gene Wiki entry for AGO1 (EIF2C1) Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
About This Section

TryGeneCards Plus
RefSeq DNA sequence at NCBI GenBank:
NC_000001.10  NT_032977.10  NC_018912.2  
Regulatory elements:
   Search for regulatory transcription factor binding sites for AGO1
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidAGO1 promoter sequence
   Search Chromatin IP Primers for AGO1

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat AGO1


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 1p34.3   Ensembl cytogenetic band:  1p34.3   HGNC cytogenetic band: 1p34.3

AGO1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
AGO1 gene location

GeneLoc information about chromosome 1         GeneLoc Exon Structure

GeneLoc location for GC01P036336:  view genomic region     (about GC identifiers)

Start:
36,335,409 bp from pter      End:
36,395,211 bp from pter
Size:
59,803 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., eBioscience, and/or antibodies-online,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., eBioscience, and/or antibodies-online, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, Cloud-Clone Corp, antibodies-online, and/or others.)
About This Section

TryGeneCards Plus

UniProtKB/Swiss-Prot: AGO1_HUMAN, Q9UL18 (See protein sequence)
Recommended Name: Protein argonaute-1  
Size: 857 amino acids; 97214 Da
Subunit: Interacts with DDB1, DDX5, DDX6, DHX30, DHX36, DDX47, DICER1, AGO2, ELAVL1, HNRNPF, IGF2BP1, ILF3, IMP8,
MATR3, MOV10, PABPC1, PRMT5, RBM4, SART3, TNRC6B, UPF1 and YBX1. Associates with polysomes and messenger
ribonucleoproteins (mNRPs). Interacts with LIMD1, WTIP and AJUBA. Interacts with APOBEC3F, APOBEC3G and APOBEC3H
5 PDB 3D structures from and Proteopedia for AGO1:
1SI2 (3D)        1SI3 (3D)        4KRE (3D)        4KRF (3D)        4KXT (3D)    
Secondary accessions: Q5TA57 Q6P4S0

Explore the universe of human proteins at neXtProt for AGO1: NX_Q9UL18

Explore proteomics data for AGO1 at MOPED

Post-translational modifications: 

  • Ubiquitination2 at Lys364
  • Modification sites at PhosphoSitePlus

  • See AGO1 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_036331.1  
    ENSEMBL proteins: 
     ENSP00000362302   ENSP00000362300  
    Reactome Protein details: Q9UL18

    AGO1 Human Recombinant Protein Products:

    Browse Purified and Recombinant Proteins at EMD Millipore
    Browse R&D Systems for human recombinant proteins
    Browse recombinant and purified proteins available from Enzo Life Sciences
    Browse OriGene full length recombinant human proteins expressed in human HEK293 cells
    OriGene Protein Over-expression Lysate for AGO1
    OriGene Custom MassSpec
    OriGene Custom Protein Services for AGO1
    GenScript Custom Purified and Recombinant Proteins Services for AGO1
    Novus Biologicals AGO1 Proteins
    Novus Biologicals AGO1 Lysate
    Sino Biological Recombinant Protein for AGO1
    Sino Biological Cell Lysate for AGO1
    Browse ProSpec Recombinant Proteins
    Browse Proteins at Cloud-Clone Corp.

     
    Search eBioscience for Proteins for AGO1 

     
    antibodies-online proteins for AGO1 (3 products) 

     
    antibodies-online peptides for AGO1

    AGO1 Antibody Products:

    EMD Millipore Mono- and Polyclonal Antibodies for the study of AGO1
    Browse R&D Systems for Antibodies
    Cell Signaling Technology (CST) Antibodies for AGO1 
    OriGene Antibodies for AGO1
    OriGene Custom Antibody Services for AGO1
    Novus Biologicals AGO1 Antibodies
    Search for Antibodies for AGO1 at Abcam
    Browse Antibodies at Cloud-Clone Corp.
    ThermoFisher Antibodies for AGO1
    antibodies-online antibodies for AGO1 (33 products) 

    AGO1 Assay Products:

    EMD Millipore Kits and Assays for the Analysis of AGO1
    OriGene Custom Assay Services for AGO1
    Browse R&D Systems for biochemical assays
    GenScript Custom Assay Services for AGO1
    Browse Enzo Life Sciences for kits & assays
    Browse ELISAs at Cloud-Clone Corp.
    Browse CLIAs at Cloud-Clone Corp.
    Search eBioscience for ELISAs for AGO1 
    antibodies-online kits for AGO1 (4 products) 


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section

    TryGeneCards Plus
    HGNC Gene Families:
    AGO: Argonaute/PIWI family

    4 InterPro protein domains:
     IPR014811 DUF1785
     IPR003165 Piwi
     IPR003100 PAZ_dom
     IPR012337 RNaseH-like_dom

    Graphical View of Domain Structure for InterPro Entry Q9UL18

    ProtoNet protein and cluster: Q9UL18

    2 Blocks protein domains:
    IPB003100 Argonaute and Dicer protein
    IPB003165 Stem cell self-renewal protein Piwi


    UniProtKB/Swiss-Prot: AGO1_HUMAN, Q9UL18
    Similarity: Belongs to the argonaute family. Ago subfamily
    Similarity: Contains 1 PAZ domain
    Similarity: Contains 1 Piwi domain


    Find genes that share domains with AGO1           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
    About This Section

    TryGeneCards Plus

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: AGO1_HUMAN, Q9UL18
    Function: Required for RNA-mediated gene silencing (RNAi). Binds to short RNAs such as microRNAs (miRNAs) or short
    interfering RNAs (siRNAs), and represses the translation of mRNAs which are complementary to them. Lacks
    endonuclease activity and does not appear to cleave target mRNAs. Also required for transcriptional gene
    silencing (TGS) of promoter regions which are complementary to bound short antigene RNAs (agRNAs)

         Gene Ontology (GO): 5 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003676nucleic acid binding ----
    GO:0003723RNA binding IDA--
    GO:0004521NOT endoribonuclease activity IDA--
    GO:0005515protein binding IPI12526743
    GO:0044822poly(A) RNA binding IDA--
         
    Find genes that share ontologies with AGO1           About GenesLikeMe


    Phenotypes:
         4 MGI mutant phenotypes (inferred from 3 alleles(MGI details for Ago1):
     homeostasis/metabolism  integument  no phenotypic analysis  normal 

    Find genes that share phenotypes with AGO1           About GenesLikeMe

    Animal Models:
       genOway: Develop your customized and physiologically relevant rodent model for AGO1

    miRNA
    Products:
        
    miRTarBase miRNAs that target AGO1:
    hsa-let-7g-5p (MIRT046562), hsa-let-7e-5p (MIRT051424), hsa-mir-484 (MIRT042384), hsa-let-7b-5p (MIRT052100), hsa-mir-20a-5p (MIRT050491), hsa-mir-503-5p (MIRT000649), hsa-mir-378a-3p (MIRT043875), hsa-mir-30c-5p (MIRT047934), hsa-mir-328-3p (MIRT043772), hsa-mir-324-5p (MIRT043039), hsa-mir-106b-5p (MIRT020459), hsa-mir-93-5p (MIRT028161), hsa-mir-212-3p (MIRT047001), hsa-mir-744-5p (MIRT037644), hsa-mir-25-3p (MIRT050300), hsa-mir-197-3p (MIRT048053), hsa-mir-19b-3p (MIRT031191), hsa-mir-17-5p (MIRT050855), hsa-mir-455-3p (MIRT037811), hsa-mir-195-5p (MIRT044872), hsa-mir-877-3p (MIRT036850), hsa-mir-148b-3p (MIRT019395), hsa-mir-320a (MIRT044422), hsa-mir-151a-5p (MIRT038199), hsa-mir-877-5p (MIRT037333), hsa-mir-326 (MIRT043633), hsa-mir-185-5p (MIRT045361), hsa-mir-130b-3p (MIRT020233), hsa-mir-18a-3p (MIRT040923), hsa-mir-149-5p (MIRT045581), hsa-mir-615-3p (MIRT040258), hsa-mir-652-3p (MIRT039533), hsa-mir-423-3p (MIRT042472), hsa-mir-628-3p (MIRT039585), hsa-mir-193b-3p (MIRT041207), hsa-mir-186-5p (MIRT044946), hsa-let-7a-5p (MIRT052451), hsa-mir-194-5p (MIRT044876), hsa-mir-92a-3p (MIRT049023), hsa-mir-106a-5p (MIRT048332), hsa-mir-34a-5p (MIRT047389), hsa-mir-31-5p (MIRT049864), hsa-mir-330-3p (MIRT043829), hsa-mir-93-3p (MIRT038746), hsa-mir-26a-5p (MIRT050091), hsa-mir-138-5p (MIRT045832), hsa-mir-421 (MIRT039391), hsa-mir-99a-5p (MIRT048678), hsa-mir-769-3p (MIRT039094), hsa-let-7c-5p (MIRT051847), hsa-mir-320c (MIRT036167), hsa-mir-146b-5p (MIRT041612), hsa-mir-29a-3p (MIRT049967), hsa-mir-30d-5p (MIRT047786)

    Block miRNA regulation of human, mouse, rat AGO1 using miScript Target Protectors
    Search for qRT-PCR Assays for microRNAs that regulate AGO1
    SwitchGear 3'UTR luciferase reporter plasmidAGO1 3' UTR sequence
    Inhib. RNA
    Products:
        
    OriGene RNAi products in human, mouse, rat for AGO1
    Predesigned siRNA for gene silencing in human, mouse, rat AGO1

    Gene Editing
    Products:
    DNA2.0 Custom Protein Engineering Service for AGO1

    Clone
    Products:
         
    OriGene clones in human, mouse for AGO1 (see all 5)
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript Custom all cDNA clones Services for AGO1
    Sino Biological Human cDNA Clone for AGO1
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for AGO1
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat AGO1
    Addgene plasmids for AGO1 

    Cell Line
    Products:
         
    GenScript Custom overexpressing Cell Line Services for AGO1
    Browse ESI BIO Cell Lines and PureStem Progenitors for AGO1 
    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for AGO1


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
    About This Section

    TryGeneCards Plus

    Subcellular locations from UniProtKB/Swiss-Prot
    AGO1_HUMAN, Q9UL18: Cytoplasm, P-body

    Gene Ontology (GO): Selected cellular component terms (see all 6):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000932cytoplasmic mRNA processing body IEA--
    GO:0005737cytoplasm IDA--
    GO:0005829cytosol TAS--
    GO:0005844polysome IDA17932509
    GO:0030529ribonucleoprotein complex IDA17932509

    Find genes that share ontologies with AGO1           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
    About This Section

    TryGeneCards Plus

    SuperPaths for AGO1 About   (see all 14)  
    See pathways by source

    SuperPathSelected contained pathways About (see all per SuperPath)
    1Signaling by FGFR
    Signaling by FGFR0.91
    DAP12 interactions0.89
    Signaling by FGFR in disease0.91
    Signaling by PDGF0.87
    Downstream signaling of activated FGFR0.91
    Signaling by EGFR0.83
    Downstream signal transduction0.90
    Signaling by EGFR in Cancer0.82
    2PI-3K cascade
    PI3K/AKT activation0.93
    PI3K events in ERBB4 signaling0.88
    GAB1 signalosome0.93
    Role of LAT2/NTAL/LAB on calcium mobilization0.80
    PIP3 activates AKT signaling0.88
    Signaling by SCF-KIT0.72
    PI-3K cascade0.88
    Signaling by ERBB40.66
    3Regulatory RNA pathways
    MicroRNA (miRNA) Biogenesis0.88
    Post-transcriptional Silencing By Small RNAs0.00
    Regulatory RNA pathways0.88
    Small Interfering RNA (siRNA) Biogenesis0.00
    4Cellular Senescence
    Cellular Senescence0.81
    Oxidative Stress Induced Senescence0.64
    Cellular responses to stress0.81
    5beta-catenin independent WNT signaling
    beta-catenin independent WNT signaling0.79
    Ca2+ pathway0.43
    Signaling by Wnt0.79


    Find genes that share SuperPaths with AGO1           About GenesLikeMe

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    2 Downloadable PowerPoint Slides of GeneGlobe Pathway Central Maps for AGO1
        GSK3 Signaling
    eIF2 Pathway

    1 Cell Signaling Technology (CST) Pathway for AGO1
        Translational Control


    Selected Reactome Pathways for AGO1 (see all 8)
        MicroRNA (miRNA) biogenesis
    Oncogene Induced Senescence
    Small interfering RNA (siRNA) biogenesis
    Oxidative Stress Induced Senescence
    Pre-NOTCH Transcription and Translation


        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for AGO1
    Interactions:

        Search GeneGlobe Interaction Network for AGO1

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for AGO1 (Q9UL181, 2, 3 ENSP000003623004) via UniProtKB, MINT, STRING, and/or I2D (see all 250)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    AGO2Q9UKV82, 3, ENSP000002205924MINT-6167681 MINT-6167695 MINT-6167661 MINT-6167702 MINT-6167688 MINT-6167709 I2D: score=2 STRING: ENSP00000220592
    PARP2Q9UGN52, 3, ENSP000002504164MINT-8202029 I2D: score=1 STRING: ENSP00000250416
    DICER1Q9UPY31, 2, 3, ENSP000003437454EBI-527363,EBI-395506 MINT-6488488 MINT-6488791 I2D: score=3 STRING: ENSP00000343745
    SART3Q150202, ENSP000002282844MINT-6167588 MINT-6488590 MINT-6488488 MINT-6488791 STRING: ENSP00000228284
    EEF1A1P681042, ENSP000003300544MINT-6488590 MINT-6488488 MINT-6488791 STRING: ENSP00000330054
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 12):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000956nuclear-transcribed mRNA catabolic process IDA18771919
    GO:0006351transcription, DNA-templated IEA--
    GO:0006355regulation of transcription, DNA-templated IEA--
    GO:0007173epidermal growth factor receptor signaling pathway TAS--
    GO:0007219Notch signaling pathway TAS--

    Find genes that share ontologies with AGO1           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
    About This Section

    TryGeneCards Plus
    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for AGO1



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
    About This Section

    TryGeneCards Plus

    REFSEQ mRNAs for AGO1 gene: 
    NM_012199.2  

    Unigene Cluster for AGO1:

    Argonaute RISC catalytic component 1
    Hs.22867  [show with all ESTs]
    Unigene Representative Sequence: NM_012199
    2 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000373206 ENST00000373204(uc001bzk.3 uc001bzl.3 uc009vuy.3)

    miRNA
    Products:
         
    Block miRNA regulation of human, mouse, rat AGO1 using miScript Target Protectors
    Search for qRT-PCR Assays for microRNAs that regulate AGO1
    SwitchGear 3'UTR luciferase reporter plasmidAGO1 3' UTR sequence
    Inhib. RNA
    Products:
         
    OriGene RNAi products in human, mouse, rat for AGO1
    Predesigned siRNA for gene silencing in human, mouse, rat AGO1
    Clone
    Products:
         
    OriGene clones in human, mouse for AGO1 (see all 5)
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript Custom all cDNA clones Services for AGO1
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for AGO1
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat AGO1
    Addgene plasmids for AGO1 
    Primer
    Products:
        
    OriGene qPCR primer pairs and template standards for AGO1
    OriGene qSTAR qPCR primer pairs in human, mouse for AGO1
    Search Pre-validated RT2 qPCR Primer Assays in human, mouse, rat AGO1
      QuantiTect SYBR Green Assays in human, mouse, rat AGO1
      QuantiFast Probe-based Assays in human, mouse, rat AGO1

    Additional mRNA sequence: 

    AF093097.1 AK000326.1 AK001622.1 AK002003.1 AK027611.1 AK314148.1 BC063275.1 CR936823.1 
    U92986.1 

    6 DOTS entries:

    DT.415593  DT.95279692  DT.91797251  DT.40108476  DT.95259083  DT.40226186 

    Selected AceView cDNA sequences (see all 165):

    BQ187004 F07607 AA326718 AI251849 AF093097 H88369 CK300071 H88431 
    W35270 BM794307 BX956010 AA699358 BE674678 BQ073251 BM975858 BF513833 
    BQ425517 BX953492 NM_012199 BE219294 F03857 AA909793 H53427 AA479593 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    TryGeneCards Plus

    AGO1 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: --
    AGO1 Expression
    About this image


    AGO1 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     
     Neural Tube (Nervous System)
             Primitive Spinal Cord
    AGO1 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    AGO1 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.22867
        Custom PCR Arrays for AGO1
    Primer
    Products:
    OriGene qPCR primer pairs and template standards for AGO1
    OriGene qSTAR qPCR primer pairs in human, mouse for AGO1
    Search Pre-validated RT2 qPCR Primer Assays in human, mouse, rat AGO1
    QuantiTect SYBR Green Assays in human, mouse, rat AGO1
    QuantiFast Probe-based Assays in human, mouse, rat AGO1
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for AGO1

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    TryGeneCards Plus

    This gene was present in the common ancestor of eukaryotes.

    Orthologs for AGO1 gene from Selected species (see all 15)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Ago11 , 5 eukaryotic translation initiation factor 2C, 15
    argonaute RISC catalytic subunit 11
    93.5(n)1
    100(a)1
      4 (60.76 cM)5
    2365111  NM_153403.21  NP_700452.21 
     1264350125 
    chicken
    (Gallus gallus)
    Aves EIF2C11 eukaryotic translation initiation factor 2C, 1 83.94(n)
    99.88(a)
      428222  XM_425781.4  XP_425781.3 
    lizard
    (Anolis carolinensis)
    Reptilia AGO16
    argonaute RISC catalytic component 1
    100(a)
    1 ↔ 1
    GL343488.1(539056-555537)
    tropical clawed frog
    (Xenopus tropicalis)
    Amphibia ago41 argonaute RISC catalytic component 4 80.98(n)
    98.25(a)
      100302589  XM_002936214.2  XP_002936260.1 
    zebrafish
    (Danio rerio)
    Actinopterygii LOC5707751 protein argonaute-1-like 80.71(n)
    96.92(a)
      570775  XM_005158472.1  XP_005158529.1 
    Alicante grape
    (Vitis vinifera)
    eudicotyledons Vvi.117072 Vitis vinifera transcribed sequence with moderate similarity more 77.83(n)    CB974988.1 
    corn
    (Zea mays)
    Liliopsida AY110984.12   -- 70.83(n)    AY110984.1 


    ENSEMBL Gene Tree for AGO1 (if available)
    TreeFam Gene Tree for AGO1 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section

    TryGeneCards Plus
    Paralogs for AGO1 gene
    PIWIL42  PIWIL22  AGO32  PIWIL12  AGO42  PIWIL32  AGO22  
    5 SIMAP similar genes for AGO1 using alignment to 2 protein entries:     AGO1_HUMAN (see all proteins):
    EIF2C2    AGO2    AGO4    AGO3    EIF2C3

    Find genes that share paralogs with AGO1           About GenesLikeMe



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
    About This Section

    TryGeneCards Plus

    Selected SNPs for AGO1 (see all 816)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 1 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1451756111,2
    --36346953(+) TTTCAC/TTCTTG 1 -- us2k10--------
    rs1821425391,2
    --36346982(+) AATGGC/TGTGAT 1 -- us2k10--------
    rs1855421721,2
    --36347112(+) GAGACA/GAGACT 1 -- us2k10--------
    rs1491471611,2
    C--36347203(+) CAGGCA/GTGAGC 1 -- us2k10--------
    rs1907363561,2
    --36347244(+) ACAAGC/TTTTCC 1 -- us2k10--------
    rs770434761,2
    C,F--36347337(+) AGGACC/TGGTTA 1 -- us2k11Minor allele frequency- T:0.05WA 118
    rs1807965251,2
    --36347464(+) CTGCAC/TCAGAC 1 -- us2k10--------
    rs1422802071,2
    --36347512(+) AGACTA/GGCAAG 1 -- us2k10--------
    rs1161885581,2
    F--36347534(+) GATACG/ATCTAG 1 -- us2k11Minor allele frequency- A:0.03WA 118
    rs115840051,2
    C,F,H--36347574(+) AAGAAA/GCCATC 1 -- us2k111Minor allele frequency- G:0.02NS EA NA 1092

    HapMap Linkage Disequilibrium report for AGO1 (36335409 - 36395211 bp)

    Structural Variations
          Database of Genomic Variants (DGV) variations for AGO1: --
    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing AGO1
    DNA2.0 Custom Variant and Variant Library Synthesis for AGO1

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section

    TryGeneCards Plus
    OMIM gene information: 606228    OMIM disorders: --


    Find genes that share disorders with AGO1           About GenesLikeMe


    Export disorders for AGO1 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    TryGeneCards Plus

    PubMed articles for AGO1 gene, integrated from 10 sources (see all 90):
    (articles sorted by number of sources associating them with AGO1)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Human eukaryotic initiation factor EIF2C1 gene: cDNA sequence, genomic organization, localization to chromosomal bands 1p34-p35, and expression. (PubMed id 10534406)1, 2, 3 Koesters R....Briner J. (Genomics 1999)
    2. Translation repression in human cells by microRNA-induced gene silencing requires RCK/p54. (PubMed id 16756390)1, 2, 9 Chu C.-Y. and Rana T.M. (PLoS Biol. 2006)
    3. Importin 8 is a gene silencing factor that targets argonaute proteins to distinct mRNAs. (PubMed id 19167051)1, 2 Weinmann L.... Meister G. (Cell 2009)
    4. Importance of translation and nonnucleolytic ago proteins for on- target RNA interference. (PubMed id 18771919)1, 2 Wu L.... Belasco J.G. (Curr. Biol. 2008)
    5. Proteomic and functional analysis of Argonaute-containing mRNA- protein complexes in human cells. (PubMed id 17932509)1, 2 Hoeck J.... Meister G. (EMBO Rep. 2007)
    6. Involvement of AGO1 and AGO2 in mammalian transcriptional silencing. (PubMed id 16936728)1, 2 Janowski B.A.... Corey D.R. (Nat. Struct. Mol. Biol. 2006)
    7. The DNA sequence and biological annotation of human chromosome 1. (PubMed id 16710414)1, 2 Gregory S.G.... Bentley D.R. (Nature 2006)
    8. Structural basis for overhang-specific small interfering RNA recognition by the PAZ domain. (PubMed id 15152257)1, 2 Ma J.-B.... Patel D.J. (Nature 2004)
    9. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    10. Identification of eight members of the Argonaute family in the human genome. (PubMed id 12906857)1, 3 Sasaki T.... Shimizu N. (Genomics 2003)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section

    TryGeneCards Plus
     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section

    TryGeneCards Plus
    Entrez Gene: 26523 HGNC: 3262 AceView: EIF2C1 Ensembl:ENSG00000092847 euGenes: HUgn26523
    ECgene: AGO1 H-InvDB: AGO1

    (According to HUGE)
    About This Section

    TryGeneCards Plus
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
    About This Section

    TryGeneCards Plus
    NameDescription
    PharmGKB entry for AGO1 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section

    TryGeneCards Plus
    Patent Information for AGO1 gene:
    Search GeneIP for patents involving AGO1

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, eBioscience, antibodies-online, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from genOway)
    About This Section

    TryGeneCards Plus

     Browse Small Molecules at EMD Millipore
     EMD Millipore Mono- and Polyclonal Antibodies for the study of AGO1
     Browse Purified and Recombinant Proteins at EMD Millipore
     EMD Millipore Kits and Assays for the Analysis of AGO1
     
     EMD Millipore genomic analysis products

      
     Browse Antibodies   Browse Cell Culture Products  
     Browse ELISAs   Browse Flow Cytometry Kits  
     Browse Primer Pairs   Browse Enzyme Activity Assays/Reagents  
     Browse ELISpot/FluoroSpot Kits/Development Modules   Browse TFB/Immunoprecipitation Assays  
     Browse Apoptosis Detection Kits/Reagents   Browse Ubiquitin Proteasome Pathway (UPP) Assay Kits/Reagents  
     Browse DNA Damage/Repair Kits/Reagents   Browse Luminex Assays  
     Browse Cell Selection/Detection Kits/Reagents   Browse Secondary Antibodies/Controls/Staining Reagents  
     Browse Recombinant/Natural Proteins   Browse Stem Cell Products  
     Browse cDNA Clones   Browse Proteome Profiler Antibody Arrays  
     OriGene Antibodies for AGO1   OriGene RNAi products in human, mouse, rat for AGO1  
     OriGene qPCR primer pairs and template standards for AGO1   OriGene Protein Over-expression Lysate for AGO1  
     OriGene Custom Mass Spec   OriGene clones in human, mouse for AGO1  
     OriGene qSTAR qPCR primer pairs in human, mouse for AGO1   Browse OriGene full length recombinant human proteins expressed in human HEK293 cells  
     Browse OriGene ORF clones   OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling  
     OriGene Custom Antibody Services for AGO1   OriGene Custom Protein Services for AGO1  

     
     
     Block miRNA regulation of human, mouse, rat AGO1 using miScript Target Protectors SeqTarget long-range PCR primers for resequencing AGO1
     DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat AGO1 Predesigned siRNA for gene silencing in human, mouse, rat AGO1
     QuantiFast Probe-based Assays in human, mouse, rat AGO1 QuantiTect SYBR Green Assays in human, mouse, rat AGO1
     Custom PCR Arrays for AGO1 Search Chromatin IP Primers for AGO1
     Search Pre-validated RT2 qPCR Primer Assays in human, mouse, rat AGO1 Search GeneGlobe Interaction Network for AGO1
     Search Regulatory tfbs for AGO1
     GenScript Custom Purified and Recombinant Proteins Services for AGO1 GenScript Custom cDNA clones with any tag delivered in your preferred vector Services for AGO1
     GenScript Custom Assay Services for AGO1 GenScript Custom overexpressing Cell Line Services for AGO1
     CloneReady with Over 120,000 Genes  Gene Synthesis: Any Gene in Any Vector
     Vector-based siRNA and miRNA, Ready for Transfection Gene Mutant Library, Variants up to 10^11
     Plasmid Preparation Custom Peptide Services
     Antibodies & Assays for AGO1 

     Search Tocris compounds for AGO1
     Proteins for AGO1
     Cell Lysates for AGO1
     cDNA Clones for AGO1
     4000+ Proteins
     Search Sino Biological for antibodies, proteins & pathways
     Protein Production Services
     Transfection Reagents
     Protein A/G/L resins
     Isotyping reagents
     Search www.enzolifesciences.com for proteins, assays, substrates, inhibitors & antibodies

     Novus Tissue Slides
     AGO1 antibodies
     AGO1 proteins
     AGO1 lysates
     Search for Antibodies for AGO1 at Abcam
     See all of Abcam's Antibodies, Kits and Proteins for AGO1
     Custom Antibody / Protein Production Service
     Bulk Purchasing
     Advantages of Rabbit Monoclonal antibodies
     Abcam protocols and scientific support
     Browse ProSpec Recombinant Proteins
     Browse Proteins at Cloud-Clone Corp.
     Browse Antibodies at Cloud-Clone Corp.
     Browse ELISAs at Cloud-Clone Corp.
     Browse CLIAs at Cloud-Clone Corp.



     Browse ESI BIO Cell Lines and PureStem Progenitors for AGO1
     Gene Synthesis
     Protein Engineering
     Variant Library Synthesis
     Codon Optimization
     Protein Production and Purification
     Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for AGO1
     SwitchGear 3'UTR luciferase reporter plasmids for AGO1
     SwitchGear Promoter luciferase reporter plasmids for AGO1
     ThermoFisher Antibodies for AGO1
     Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat AGO1
     Browse compounds at ApexBio
     Addgene plasmids for AGO1
      Search eBioscience for proteins for AGO1
      Search eBioscience for elisas for AGO1
      eBioscience FlowRNA Probe Sets
     genOway: Develop your customized and physiologically relevant rodent model for AGO1
     antibodies-online antibodies for AGO1 (33 products)
     antibodies-online kits for AGO1 (4 products)
     antibodies-online peptides for AGO1
     antibodies-online proteins for AGO1 (3 products)
           
    GeneCards Homepage - Last full update: 7 May 2014 - Incrementals: 9 May 2014 , 2 Jun 2014 , 26 Jun 2014 , 30 Jun 2014 , 21 Aug 2014 , 8 Sep 2014 , 7 Oct 2014

    View Random Gene

    Category
    (GIFtS: )
    GIFtS Group
    The GeneCards human gene database gene index: 1 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z 


    Developed at the Crown Human Genome Center, Department of Molecular Genetics, the Weizmann Institute of Science

    Hot genes      Disease genes      AGO1 gene at Home site.
    Version: 3.12.252 27 Nov 2014
    hostname: 356980-web2.xennexinc.com index build: 128 solr: 1.4