Set Analyses:
Advanced Search

Advanced Search

 
Search By
Section (entire)
for


 
or upload a file of gene symbols


Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

AGO1 Gene

protein-coding   GIFtS: 50
GCID: GC01P036336

Argonaute RISC Catalytic Component 1

(Previous names: eukaryotic translation initiation factor 2C, 1)
(Previous symbol: EIF2C1)
Microbiology & Infectious Diseases Congress
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
Argonaute RISC Catalytic Component 11 2 3     EIF2C2 5
EIF2C11 2 3 5     GERP952 5
Eukaryotic Translation Initiation Factor 2C, 11 2     Q992
Argonaute 11 2     argonaute12
Putative RNA-Binding Protein Q992 3     Golgi Endoplasmic Reticulum Protein 95 KDa2
EIF-2C 12 3     Protein Argonaute-12
EIF2C 12 3     Argonaute13
hAgo12 3     Eukaryotic Translation Initiation Factor 2C 13

External Ids:    HGNC: 32621   Entrez Gene: 265232   Ensembl: ENSG000000928477   OMIM: 6062285   UniProtKB: Q9UL183   

Export aliases for AGO1 gene to outside databases


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for AGO1 Gene:
This gene encodes a member of the Argonaute family of proteins which play a role in RNA interference. The encoded
protein is highly basic, and contains a PAZ domain and a PIWI domain. It may interact with dicer1 and play a role
in short-interfering-RNA-mediated gene silencing. This gene is located on chromosome 1 in a cluster of closely
related family members including argonaute 3, and argonaute 4. (provided by RefSeq, Jul 2008)

GeneCards Summary for AGO1 Gene: 
AGO1 (argonaute RISC catalytic component 1) is a protein-coding gene. Diseases associated with AGO1 include estrogen-receptor negative breast cancer, and skin cancer, and among its related super-pathways are Signaling by FGFR and Constitutive PI3K/AKT Signaling in Cancer. GO annotations related to this gene include protein binding and RNA binding. An important paralog of this gene is PIWIL4.

UniProtKB/Swiss-Prot: AGO1_HUMAN, Q9UL18
Function: Required for RNA-mediated gene silencing (RNAi). Binds to short RNAs such as microRNAs (miRNAs) or short
interfering RNAs (siRNAs), and represses the translation of mRNAs which are complementary to them. Lacks
endonuclease activity and does not appear to cleave target mRNAs. Also required for transcriptional gene
silencing (TGS) of promoter regions which are complementary to bound short antigene RNAs (agRNAs)

Gene Wiki entry for AGO1 (EIF2C1) Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000001.10  NT_032977.9  NC_018912.2  
Regulatory elements:
   Search SABiosciences Regulatory transcription factor binding sites for AGO1
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidAGO1 promoter sequence
   Search SABiosciences Chromatin IP Primers for AGO1

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat AGO1


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 1p34.3   Ensembl cytogenetic band:  1p34.3   HGNC cytogenetic band: 1p34.3

AGO1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
AGO1 gene location

GeneLoc information about chromosome 1         GeneLoc Exon Structure

GeneLoc location for GC01P036336:  view genomic region     (about GC identifiers)

Start:
36,335,409 bp from pter      End:
36,395,211 bp from pter
Size:
59,803 bases      Orientation:
plus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: AGO1_HUMAN, Q9UL18 (See protein sequence)
Recommended Name: Protein argonaute-1  
Size: 857 amino acids; 97214 Da
Subunit: Interacts with DDB1, DDX5, DDX6, DHX30, DHX36, DDX47, DICER1, AGO2, ELAVL1, HNRNPF, IGF2BP1, ILF3, IMP8,
MATR3, MOV10, PABPC1, PRMT5, RBM4, SART3, TNRC6B, UPF1 and YBX1. Associates with polysomes and messenger
ribonucleoproteins (mNRPs). Interacts with LIMD1, WTIP and AJUBA. Interacts with APOBEC3F, APOBEC3G and APOBEC3H
Subcellular location: Cytoplasm, P-body
2 PDB 3D structures from and Proteopedia for AGO1:
1SI2 (3D)        1SI3 (3D)    
Secondary accessions: Q5TA57 Q6P4S0

Explore the universe of human proteins at neXtProt for AGO1: NX_Q9UL18

Explore proteomics data for AGO1 at MOPED 

Post-translational modifications:

  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_Q9UL18

  • AGO1 Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    AGO1 Protein Expression
    REFSEQ proteins: NP_036331.1  
    ENSEMBL proteins: 
     ENSP00000362302   ENSP00000362300  
    Reactome Protein details: Q9UL18
    Human Recombinant Protein Products for AGO1: 
    Browse Purified and Recombinant Proteins at EMD Millipore
    Browse R&D Systems for human recombinant proteins
    Browse recombinant and purified proteins available from Enzo Life Sciences
    Browse OriGene full length recombinant human proteins expressed in human HEK293 cells
    OriGene Protein Over-expression Lysate for AGO1
    OriGene Custom MassSpec 
    OriGene Custom Protein Services for AGO1
    GenScript Custom Purified and Recombinant Proteins Services for AGO1
    Novus Biologicals AGO1 Proteins
    Novus Biologicals AGO1 Lysate
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates 
    Browse ProSpec Recombinant Proteins
    Browse Proteins at Cloud-Clone Corp. 

    Gene Ontology (GO): 5/6 cellular component terms (GO ID links to tree view) (see all 6):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000932cytoplasmic mRNA processing body IEA--
    GO:0005737cytoplasm IDA--
    GO:0005829cytosol TAS--
    GO:0005844polysome IDA17932509
    GO:0030529ribonucleoprotein complex IDA17932509

    AGO1 for ontologies           About GeneDecksing



    AGO1 Antibody Products: 
    EMD Millipore Mono- and Polyclonal Antibodies for the study of AGO1
    Browse R&D Systems for Antibodies
    Cell Signaling Technology (CST) Antibodies for AGO1 
    OriGene Antibodies for AGO1
    OriGene Custom Antibody Services for AGO1
    GenScript Custom Superior Antibodies Services for AGO1
    Novus Biologicals AGO1 Antibodies
    Abcam antibodies for AGO1
    Browse Antibodies at Cloud-Clone Corp. 
    ThermoFisher Antibodies for AGO1
    Search LSBio for Antibodies for AGO1 

    Assay Products for AGO1: 
    Browse Kits and Assays available from EMD Millipore
    OriGene Custom Assay Services for AGO1
    Browse R&D Systems for biochemical assays
    GenScript Custom Assay Services for AGO1
    Browse Enzo Life Sciences for kits & assays
    Browse ELISAs at Cloud-Clone Corp. 
    Browse CLIAs at Cloud-Clone Corp.


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    HGNC Gene Families: 
    AGO: Argonaute/PIWI family

    4 InterPro protein domains:
     IPR014811 DUF1785
     IPR003165 Piwi
     IPR003100 PAZ
     IPR012337 RNaseH-like_dom

    Graphical View of Domain Structure for InterPro Entry Q9UL18

    ProtoNet protein and cluster: Q9UL18

    2 Blocks protein domains:
    IPB003100 Argonaute and Dicer protein
    IPB003165 Stem cell self-renewal protein Piwi


    UniProtKB/Swiss-Prot: AGO1_HUMAN, Q9UL18
    Similarity: Belongs to the argonaute family. Ago subfamily
    Similarity: Contains 1 PAZ domain
    Similarity: Contains 1 Piwi domain


    AGO1 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: AGO1_HUMAN, Q9UL18
    Function: Required for RNA-mediated gene silencing (RNAi). Binds to short RNAs such as microRNAs (miRNAs) or short
    interfering RNAs (siRNAs), and represses the translation of mRNAs which are complementary to them. Lacks
    endonuclease activity and does not appear to cleave target mRNAs. Also required for transcriptional gene
    silencing (TGS) of promoter regions which are complementary to bound short antigene RNAs (agRNAs)

         Gene Ontology (GO): 3 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003676nucleic acid binding ----
    GO:0003723RNA binding IEA--
    GO:0005515protein binding IPI12526743
         
    AGO1 for ontologies           About GeneDecksing


    Phenotypes:
         4 MGI mutant phenotypes (inferred from 3 alleles(MGI details for Ago1):
     homeostasis/metabolism  integument  no phenotypic analysis  normal 

    AGO1 for phenotypes           About GeneDecksing

    Animal Models:
       inGenious Targeting Laboratory - Custom generated mouse model solutions for AGO1 
       inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for AGO1

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for AGO1 
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for AGO1 

    miRNA
    Products:
        
    miRTarBase miRNAs that target AGO1:
    hsa-mir-503 (MIRT000649)

    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat AGO1
    Search QIAGEN for miScript miRNA Assays for microRNAs that regulate AGO1
    SwitchGear 3'UTR luciferase reporter plasmidAGO1 3' UTR sequence
    Inhib. RNA
    Products:
        
    Browse for Gene Knock-down Tools from EMD Millipore
    OriGene RNAi products in human, mouse, rat for AGO1
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat AGO1

    Gene Editing
    Products:
    DNA2.0 Custom Protein Engineering Service for AGO1
    Sirion Biotech Customized adenovirus for overexpression of AGO1

    Clone
    Products:
         
    Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
    OriGene clones in human, mouse for AGO1 (see all 6)
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript Custom all cDNA clones Services for AGO1
    Browse Sino Biological Human cDNA Clones
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for AGO1
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat AGO1
    Sirion Biotech Customized lentivirus for stable overexpression of AGO1 
                         Customized lentivirus expression plasmids for stable overexpression of AGO1 

    Cell Line
    Products:
         
    GenScript Custom overexpressing Cell Line Services for AGO1
    Search LifeMap BioReagents cell lines for AGO1
    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for AGO1


    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section

    SuperPaths for AGO1 About   (see all 13)                                                                                              See pathways by source

    SuperPathSelected contained pathways About (see all per SuperPath)
    1Signaling by FGFR
    Downstream signaling of activated FGFR0.92
    Downstream signal transduction0.90
    Signaling by FGFR0.92
    Signaling by PDGF0.85
    Signaling by FGFR in disease0.91
    Signaling by EGFR0.84
    DAP12 signaling0.91
    Signaling by EGFR in Cancer0.83
    2PIP3 activates AKT signaling
    GAB1 signalosome0.93
    PI3K events in ERBB2 signaling0.88
    PI3K/AKT activation0.93
    PI3K events in ERBB4 signaling0.88
    PIP3 activates AKT signaling0.88
    Signaling by SCF-KIT0.72
    PI-3K cascade0.88
    Signaling by ERBB40.67
    3Post-transcriptional Silencing By Small RNAs
    Post-transcriptional Silencing By Small RNAs0.58
    Small Interfering RNA (siRNA) Biogenesis0.40
    Pre-NOTCH Transcription and Translation0.58
    4Immune System
    Immune System0.56
    Innate Immune System0.50
    Adaptive Immune System0.56
    5Regulatory RNA pathways
    MicroRNA (miRNA) Biogenesis0.88
    Regulatory RNA pathways0.88

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways


    1 Cell Signaling Technology (CST) Pathway for AGO1
        Translational Control

    5/38        Reactome Pathways for AGO1 (see all 38)
        Signaling by EGFR in Cancer
    Downstream signal transduction
    Signal Transduction
    Regulatory RNA pathways
    Signaling by PDGF



    AGO1 for pathways           About GeneDecksing

    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for AGO1

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    5/210 Interacting proteins for AGO1 (Q9UL181, 2, 3 ENSP000003623004) via UniProtKB, MINT, STRING, and/or I2D (see all 210)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    AGO2Q9UKV82, 3, ENSP000002205924MINT-6167681 MINT-6167695 MINT-6167661 MINT-6167702 MINT-6167688 MINT-6167709 I2D: score=2 STRING: ENSP00000220592
    PARP2Q9UGN52, 3, ENSP000002504164MINT-8202029 I2D: score=1 STRING: ENSP00000250416
    DICER1Q9UPY31, 2, 3, ENSP000003437454EBI-527363,EBI-395506 MINT-6488488 MINT-6488791 I2D: score=3 STRING: ENSP00000343745
    SART3Q150202, ENSP000002282844MINT-6167588 MINT-6488590 MINT-6488488 MINT-6488791 STRING: ENSP00000228284
    DHX36Q9H2U12, ENSP000004170784MINT-6167681 MINT-6488590 MINT-6488791 STRING: ENSP00000417078
    About this table

    Gene Ontology (GO): 5/12 biological process terms (GO ID links to tree view) (see all 12):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000956nuclear-transcribed mRNA catabolic process IDA18771919
    GO:0006351transcription, DNA-dependent IEA--
    GO:0006355regulation of transcription, DNA-dependent IEA--
    GO:0007173epidermal growth factor receptor signaling pathway TAS--
    GO:0007219Notch signaling pathway TAS--

    AGO1 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for AGO1

    Search CenterWatch for drugs/clinical trials and news about AGO1

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for AGO1 gene: 
    NM_012199.2  

    Unigene Cluster for AGO1:

    Argonaute RISC catalytic component 1
    Hs.22867  [show with all ESTs]
    Unigene Representative Sequence: NM_012199
    2 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000373206 ENST00000373204(uc001bzk.3 uc001bzl.3 uc009vuy.3)

    Congresses - knowledge worth sharing:  
    European Congress of Clinical Microbiology and Infectious Diseases (ECCMID) 10 - 13 May 2014

    miRNA
    Products:
         
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat AGO1
    Search QIAGEN for miScript miRNA Assays for microRNAs that regulate AGO1
    SwitchGear 3'UTR luciferase reporter plasmidAGO1 3' UTR sequence
    Inhib. RNA
    Products:
         
    Browse for Gene Knock-down Tools from EMD Millipore
    OriGene RNAi products in human, mouse, rat for AGO1
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat AGO1
    Clone
    Products:
         
    OriGene clones in human, mouse for AGO1 (see all 6)
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript Custom all cDNA clones Services for AGO1
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for AGO1
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat AGO1
    Sirion Biotech Customized lentivirus for stable overexpression of AGO1 
                         Customized lentivirus expression plasmids for stable overexpression of AGO1 
    Primer
    Products:
        
    OriGene qPCR primer pairs and template standards for AGO1
    OriGene qSTAR qPCR primer pairs in human, mouse for AGO1
    Search SABiosciences RT2 qPCR Primer Assays in human, mouse, rat AGO1
      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat AGO1
      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat AGO1

    Additional mRNA sequence: 

    AF093097.1 AK000326.1 AK001622.1 AK002003.1 AK027611.1 AK314148.1 BC063275.1 CR936823.1 
    U92986.1 

    6 DOTS entries:

    DT.415593  DT.95279692  DT.91797251  DT.40108476  DT.95259083  DT.40226186 

    24/165 AceView cDNA sequences (see all 165):

    BQ425517 NM_012199 BQ446036 BU687788 BQ073251 BM794307 CK300071 BQ187004 
    H88369 BG236359 BI094423 AU132504 AA477432 AA453723 BC063275 AI342074 
    BE467699 AA326718 AI242569 BF438013 AI251849 AA699358 AA447772 BX956010 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    AGO1 expression in normal human tissues (normalized intensities)      AGO1 embryonic expression: see
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: --
    AGO1 Expression
    About this image


    AGO1 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database 
     5/2 selected tissues (see all 2) fully expand
     
     Blood (Hematopoietic System)
             platelets   
     
     Neural Tube (Nervous System)
             Primitive Spinal Cord

    See AGO1 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for AGO1

    SOURCE GeneReport for Unigene cluster: Hs.22867
        SABiosciences Custom PCR Arrays for AGO1
    Primer
    Products:
    OriGene qPCR primer pairs and template standards for AGO1
    OriGene qSTAR qPCR primer pairs in human, mouse for AGO1
    Search SABiosciences RT2 qPCR Primer Assays in human, mouse, rat AGO1
    QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat AGO1
    QIAGEN QuantiFast Probe-based Assays in human, mouse, rat AGO1
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for AGO1

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of eukaryotes.

    Orthologs for AGO1 gene from 6/14 species (see all 14)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Ago15
    Eif2c11
    eukaryotic translation initiation factor 2C, 11, 5 93.5(n)1
    100(a)1
      4 (60.76 cM)5
    2365111  NM_153403.21  NP_700452.21 
     1264350125 
    chicken
    (Gallus gallus)
    Aves EIF2C11 eukaryotic translation initiation factor 2C, 1 83.94(n)
    99.88(a)
      428222  XM_425781.3  XP_425781.3 
    lizard
    (Anolis carolinensis)
    Reptilia AGO16
    argonaute RISC catalytic component 1
    100(a)
    1 ↔ 1
    GL343488.1(539056-555537)
    zebrafish
    (Danio rerio)
    Actinopterygii LOC5707751 protein argonaute-1-like 80.68(n)
    96.81(a)
      570775  XM_694292.5  XP_699384.4 
    Alicante grape
    (Vitis vinifera)
    eudicotyledons Vvi.117072 Vitis vinifera transcribed sequence with moderate similarity more 77.83(n)    CB974988.1 
    corn
    (Zea mays)
    Liliopsida AY110984.12   -- 70.83(n)    AY110984.1 


    ENSEMBL Gene Tree for AGO1 (if available)
    TreeFam Gene Tree for AGO1 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for AGO1 gene
    PIWIL42  PIWIL22  AGO32  PIWIL12  AGO42  PIWIL32  AGO22  
    5 SIMAP similar genes for AGO1 using alignment to 2 protein entries:     AGO1_HUMAN (see all proteins):
    EIF2C2    AGO2    AGO4    AGO3    EIF2C3

    AGO1 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/816 SNPs in AGO1 are shown (see all 816)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 1 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1451756111,2
    --36346953(+) TTTCAC/TTCTTG 1 -- us2k10--------
    rs1821425391,2
    --36346982(+) AATGGC/TGTGAT 1 -- us2k10--------
    rs1855421721,2
    --36347112(+) GAGACA/GAGACT 1 -- us2k10--------
    rs1491471611,2
    C--36347203(+) CAGGCA/GTGAGC 1 -- us2k10--------
    rs1907363561,2
    --36347244(+) ACAAGC/TTTTCC 1 -- us2k10--------
    rs770434761,2
    C,F--36347337(+) AGGACC/TGGTTA 1 -- us2k11Minor allele frequency- T:0.05WA 118
    rs1807965251,2
    --36347464(+) CTGCAC/TCAGAC 1 -- us2k10--------
    rs1422802071,2
    --36347512(+) AGACTA/GGCAAG 1 -- us2k10--------
    rs1161885581,2
    F--36347534(+) GATACG/ATCTAG 1 -- us2k11Minor allele frequency- A:0.03WA 118
    rs115840051,2
    C,F,H--36347574(+) AAGAAA/GCCATC 1 -- us2k111Minor allele frequency- G:0.02NS EA NA 1092

    HapMap Linkage Disequilibrium report for AGO1 (36335409 - 36395211 bp)

    Structural Variations
          Database of Genomic Variants (DGV) variations for AGO1: --
    SABiosciences Cancer Mutation PCR Assays
    SeqTarget long-range PCR primers for resequencing AGO1
    DNA2.0 Custom Variant and Variant Library Synthesis for AGO1

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    OMIM gene information: 606228    OMIM disorders: --

    9 diseases for AGO1:    About MalaCards
    estrogen-receptor negative breast cancer    skin cancer    esophageal cancer    renal cell carcinoma
    esophagitis    neuroblastoma    colorectal cancer    lung cancer
    breast cancer


    AGO1 for disorders           About GeneDecksing


    Export disorders for AGO1 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for AGO1 gene, integrated from 9 sources (see all 87):
    (articles sorted by number of sources associating them with AGO1)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Human eukaryotic initiation factor EIF2C1 gene: cDNA sequence, genomic organization, localization to chromosomal bands 1p34-p35, and expression. (PubMed id 10534406)1, 2, 3 Koesters R....Briner J. (1999)
    2. Translation repression in human cells by microRNA-induced gene silencing requires RCK/p54. (PubMed id 16756390)1, 2, 9 Chu C.-Y. and Rana T.M. (2006)
    3. Importin 8 is a gene silencing factor that targets argonaute proteins to distinct mRNAs. (PubMed id 19167051)1, 2 Weinmann L.... Meister G. (2009)
    4. Importance of translation and nonnucleolytic ago proteins for on- target RNA interference. (PubMed id 18771919)1, 2 Wu L.... Belasco J.G. (2008)
    5. Proteomic and functional analysis of Argonaute-containing mRNA- protein complexes in human cells. (PubMed id 17932509)1, 2 Hoeck J.... Meister G. (2007)
    6. Involvement of AGO1 and AGO2 in mammalian transcriptional silencing. (PubMed id 16936728)1, 2 Janowski B.A.... Corey D.R. (2006)
    7. The DNA sequence and biological annotation of human chromosome 1. (PubMed id 16710414)1, 2 Gregory S.G.... Bentley D.R. (2006)
    8. Structural basis for overhang-specific small interfering RNA recognition by the PAZ domain. (PubMed id 15152257)1, 2 Ma J.-B.... Patel D.J. (2004)
    9. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    10. Identification of eight members of the Argonaute family in the human genome. (PubMed id 12906857)1, 3 Sasaki T.... Shimizu N. (2003)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 26523 HGNC: 3262 AceView: EIF2C1 Ensembl:ENSG00000092847 euGenes: HUgn26523
    ECgene: AGO1 H-InvDB: AGO1

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for AGO1 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for AGO1 gene:
    Search GeneIP for patents involving AGO1

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0 and Sirion Biotech, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Sirion Biotech, Cell lines from GenScript, and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
    About This Section

     EMD Millipore Mono- and Polyclonal Antibodies for the study of AGO1
     Browse Small Molecules at EMD Millipore
     Browse Purified and Recombinant Proteins at EMD Millipore
     Browse Kits and Assays available from EMD Millipore
     Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
     Browse for Gene Knock-down Tools from EMD Millipore
     
     EMD Millipore Custom Antibody & Bulk Services
     EMD Millipore Preclinical / Clinical Development Services
     EMD Millipore Immunoassay Services
     EMD Millipore Target Screening & Profiling Services

      
     Browse Antibodies   Browse Cell Culture Products  
     Browse ELISAs   Browse Flow Cytometry Kits  
     Browse Primer Pairs   Browse Kinase Activity Assays/Reagents  
     Browse ELISpot Kits/Development Modules   Browse TFB/Immunoprecipitation Assays  
     Browse Apoptosis Detection Kits/Reagents   Browse Ubiquitin Proteasome Pathway (UPP) Assay Kits/Reagents  
     Browse DNA Damage/Repair Kits/Reagents   Browse Multiplex/Array Assay Kits/Reagents  
     Browse Cell Selection/Detection Kits/Reagents   Browse Secondary Antibodies/Controls/Staining Reagents  
     Browse Protease Activity Assays and Reagents   Browse Recombinant/Natural Proteins  
     Browse Stem Cell Products   Browse Tocris Biochemicals & Compounds  
     Browse cDNA Clones   Browse Proteome Profiler Antibody Arrays  
     OriGene Antibodies for AGO1   OriGene RNAi products in human, mouse, rat for AGO1  
     OriGene qPCR primer pairs and template standards for AGO1   OriGene Protein Over-expression Lysate for AGO1  
     OriGene Custom Mass Spec   OriGene clones in human, mouse for AGO1  
     OriGene qSTAR qPCR primer pairs in human, mouse for AGO1   Browse OriGene full length recombinant human proteins expressed in human HEK293 cells  
     Browse OriGene ORF clones   OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling  
     OriGene Custom Antibody Services for AGO1   OriGene Custom Protein Services for AGO1  

     
     
     QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat AGO1
     QIAGEN SeqTarget long-range PCR primers for resequencing AGO1
     QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat AGO1
     QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat AGO1
     QIAGEN QuantiFast Probe-based Assays in human, mouse, rat AGO1
     QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat AGO1
     GenScript Custom Purified and Recombinant Proteins Services for AGO1 GenScript Custom cDNA clones with any tag delivered in your preferred vector Services for AGO1
     GenScript Custom Assay Services for AGO1 GenScript Custom Superior Antibodies Services for AGO1
     GenScript Custom overexpressing Cell Line Services for AGO1 CloneReady with Over 120,000 Genes
     Gene Synthesis: Any Gene in Any Vector Vector-based siRNA and miRNA, Ready for Transfection
     Gene Mutant Library, Variants up to 10^11 Plasmid Preparation
     Custom Peptide Services
     Antibodies & Assays for AGO1 

     Search Regulatory tfbs for AGO1
     Search Chromatin IP Primers for AGO1
     Search RT2 qPCR Primer Assays in human, mouse, rat AGO1
     Search GNC Networks for AGO1
     SABiosciences Custom PCR Arrays for AGO1
     Search Tocris compounds for AGO1
     Browse Sino Biological Proteins and Antibodies
     Browse Sino Biological Cell Lysates
     Browse Sino Biological cDNA Clones
     4000+ Proteins
     Search Sino Biological for antibodies, proteins & pathways
     Protein Production Services
     Transfection Reagents
     Protein A/G/L resins
     Isotyping reagents
     Search www.enzolifesciences.com for proteins, assays, substrates, inhibitors & antibodies
     Novus Tissue Slides
     AGO1 antibodies
     AGO1 proteins
     AGO1 lysates
     Antibodies for AGO1
     See all of Abcam's Antibodies, Kits and Proteins for AGO1
     Custom Antibody / Protein Production Service
     Bulk Purchasing
     Advantages of Rabbit Monoclonal antibodies
     Abcam protocols and scientific support
     Browse ProSpec Recombinant Proteins




     Browse Proteins at Cloud-Clone Corp.
     Browse Antibodies at Cloud-Clone Corp.
     Browse ELISAs at Cloud-Clone Corp.
     Browse CLIAs at Cloud-Clone Corp.
     Search LifeMap BioReagents cell lines for AGO1
     Gene Synthesis
     Protein Engineering
     Variant Library Synthesis
     Codon Optimization
     Protein Production and Purification
     Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for AGO1
     SwitchGear 3'UTR luciferase reporter plasmids for AGO1
     SwitchGear Promoter luciferase reporter plasmids for AGO1
     ThermoFisher Antibodies for AGO1
     Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat AGO1
     inGenious Targeting Laboratory - Custom generated mouse model solutions for AGO1
     inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for AGO1
    Customized:
     lentivirus for stable overexpression of AGO1
     lentivirus expression plasmids for stable overexpression of AGO1
     adenovirus for overexpression of AGO1
     Search LSBio for Antibodies for AGO1
    Customized transgenic rodents for:
     Humanization
     Biomarker expression
     Off-target effect monitoring
     Translational medicine
     Tissue-specific gene expresssion
     Time-controlled gene expresssion
           
    GeneCards Homepage - Last full update: 23 Oct 2013 - Incrementals: 4 Nov 2013 , 7 Nov 2013 , 23 Jan 2014

    View Random Gene

    Category
    (GIFtS: 73)
    transforming growth factor, beta 1
    GIFtS Group
    The GeneCards human gene database gene index: 1 3 5 6 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z 


    Developed at the Crown Human Genome Center, Department of Molecular Genetics, the Weizmann Institute of Science

    Hot genes      Disease genes      AGO1 gene at Home site.
    hostname: 356980-web2.xennexinc.com index build: 106 solr: 1.4