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Aliases for AGO1 Gene

Aliases for AGO1 Gene

  • Argonaute RISC Catalytic Component 1 2 3 4
  • EIF2C1 3 4 6
  • Eukaryotic Translation Initiation Factor 2C, 1 2 3
  • Putative RNA-Binding Protein Q99 3 4
  • Argonaute 1 2 3
  • Argonaute1 3 4
  • EIF-2C 1 3 4
  • EIF2C 1 3 4
  • GERP95 3 6
  • EIF2C 3 6
  • HAgo1 3 4
  • Eukaryotic Translation Initiation Factor 2C 1 4
  • Golgi Endoplasmic Reticulum Protein 95 KDa 3
  • Protein Argonaute-1 3
  • Q99 3

External Ids for AGO1 Gene

Previous HGNC Symbols for AGO1 Gene

  • EIF2C1

Previous GeneCards Identifiers for AGO1 Gene

  • GC01P036336

Summaries for AGO1 Gene

Entrez Gene Summary for AGO1 Gene

  • This gene encodes a member of the Argonaute family of proteins which play a role in RNA interference. The encoded protein is highly basic, and contains a PAZ domain and a PIWI domain. It may interact with dicer1 and play a role in short-interfering-RNA-mediated gene silencing. This gene is located on chromosome 1 in a cluster of closely related family members including argonaute 3, and argonaute 4. [provided by RefSeq, Jul 2008]

GeneCards Summary for AGO1 Gene

AGO1 (Argonaute RISC Catalytic Component 1) is a Protein Coding gene. Among its related pathways are PI-3K cascade and PI-3K cascade. GO annotations related to this gene include RNA binding. An important paralog of this gene is PIWIL4.

UniProtKB/Swiss-Prot for AGO1 Gene

  • Required for RNA-mediated gene silencing (RNAi). Binds to short RNAs such as microRNAs (miRNAs) or short interfering RNAs (siRNAs), and represses the translation of mRNAs which are complementary to them. Lacks endonuclease activity and does not appear to cleave target mRNAs. Also required for transcriptional gene silencing (TGS) of promoter regions which are complementary to bound short antigene RNAs (agRNAs).

Gene Wiki entry for AGO1 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for AGO1 Gene

Genomics for AGO1 Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for AGO1 Gene

Start:
35,869,808 bp from pter
End:
35,929,610 bp from pter
Size:
59,803 bases
Orientation:
Plus strand

Genomic View for AGO1 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for AGO1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for AGO1 Gene

No data available for Regulatory Elements for AGO1 Gene

Proteins for AGO1 Gene

  • Protein details for AGO1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9UL18-AGO1_HUMAN
    Recommended name:
    Protein argonaute-1
    Protein Accession:
    Q9UL18
    Secondary Accessions:
    • Q5TA57
    • Q6P4S0

    Protein attributes for AGO1 Gene

    Size:
    857 amino acids
    Molecular mass:
    97214 Da
    Quaternary structure:
    • Interacts with DDB1, DDX5, DDX6, DHX30, DHX36, DDX47, DICER1, AGO2, ELAVL1, HNRNPF, IGF2BP1, ILF3, IMP8, MATR3, MOV10, PABPC1, PRMT5, RBM4, SART3, TNRC6B, UPF1 and YBX1. Associates with polysomes and messenger ribonucleoproteins (mNRPs). Interacts with LIMD1, WTIP and AJUBA. Interacts with APOBEC3F, APOBEC3G and APOBEC3H.
    Miscellaneous:
    • Lacks RNA cleavage activity due to the absence of the conserved His at position 805, but also because it binds the RNA in a subtly different manner that precludes efficient cleavage

    Three dimensional structures from OCA and Proteopedia for AGO1 Gene

neXtProt entry for AGO1 Gene

Proteomics data for AGO1 Gene at MOPED

Post-translational modifications for AGO1 Gene

  • Ubiquitination at Lys364
  • Modification sites at PhosphoSitePlus

Other Protein References for AGO1 Gene

ENSEMBL proteins:
Reactome Protein details:
REFSEQ proteins:

No data available for DME Specific Peptides for AGO1 Gene

Domains for AGO1 Gene

Gene Families for AGO1 Gene

HGNC:
  • AGO :Argonaute/PIWI family

Graphical View of Domain Structure for InterPro Entry

Q9UL18

UniProtKB/Swiss-Prot:

AGO1_HUMAN :
  • Q9UL18
Domain:
  • Contains 1 PAZ domain.
  • Contains 1 Piwi domain.
Family:
  • Belongs to the argonaute family. Ago subfamily.
genes like me logo Genes that share domains with AGO1: view

No data available for Suggested Antigen Peptide Sequences for AGO1 Gene

Function for AGO1 Gene

Molecular function for AGO1 Gene

UniProtKB/Swiss-Prot Function: Required for RNA-mediated gene silencing (RNAi). Binds to short RNAs such as microRNAs (miRNAs) or short interfering RNAs (siRNAs), and represses the translation of mRNAs which are complementary to them. Lacks endonuclease activity and does not appear to cleave target mRNAs. Also required for transcriptional gene silencing (TGS) of promoter regions which are complementary to bound short antigene RNAs (agRNAs).

Gene Ontology (GO) - Molecular Function for AGO1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000978 RNA polymerase II core promoter proximal region sequence-specific DNA binding IEA --
GO:0000993 RNA polymerase II core binding IDA 25336585
GO:0001047 core promoter binding IMP 25336585
GO:0003676 nucleic acid binding --
GO:0003723 RNA binding IDA 23809764
genes like me logo Genes that share ontologies with AGO1: view
genes like me logo Genes that share phenotypes with AGO1: view

Animal Model Products

CRISPR Products

miRNA for AGO1 Gene

miRTarBase miRNAs that target AGO1

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for AGO1

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Animal Models , Transcription Factor Targeting and HOMER Transcription for AGO1 Gene

Localization for AGO1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for AGO1 Gene

Cytoplasm, P-body.

Gene Ontology (GO) - Cellular Components for AGO1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000932 cytoplasmic mRNA processing body IEA --
GO:0005634 nucleus IC 25336585
GO:0005654 nucleoplasm TAS --
GO:0005737 cytoplasm IDA 15260970
GO:0005829 cytosol TAS --
genes like me logo Genes that share ontologies with AGO1: view

No data available for Subcellular locations from COMPARTMENTS for AGO1 Gene

Pathways for AGO1 Gene

genes like me logo Genes that share pathways with AGO1: view

Pathways by source for AGO1 Gene

2 Qiagen pathways for AGO1 Gene
1 Cell Signaling Technology pathway for AGO1 Gene

Gene Ontology (GO) - Biological Process for AGO1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000956 nuclear-transcribed mRNA catabolic process IDA 18771919
GO:0006351 transcription, DNA-templated IEA --
GO:0006355 regulation of transcription, DNA-templated --
GO:0007173 epidermal growth factor receptor signaling pathway TAS --
GO:0007219 Notch signaling pathway TAS --
genes like me logo Genes that share ontologies with AGO1: view

Transcripts for AGO1 Gene

Unigene Clusters for AGO1 Gene

Argonaute RISC catalytic component 1:
Representative Sequences:

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for AGO1

Primer Products

  • QuantiTect SYBR Green Assays in human,mouse,rat
  • Pre-validated RT² qPCR Primer Assay in human,mouse,rat
  • QuantiFast Probe-based Assays in human,mouse,rat

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for AGO1 Gene

No ASD Table

Relevant External Links for AGO1 Gene

GeneLoc Exon Structure for
AGO1
ECgene alternative splicing isoforms for
AGO1

Expression for AGO1 Gene

mRNA expression in normal human tissues for AGO1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for AGO1 Gene

SOURCE GeneReport for Unigene cluster for AGO1 Gene Hs.22867

genes like me logo Genes that share expressions with AGO1: view

In Situ Assay Products

No data available for mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for AGO1 Gene

Orthologs for AGO1 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for AGO1 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia EIF2C1 35
  • 99.81 (n)
  • 100 (a)
EIF2C1 36
  • 100 (a)
OneToOne
cow
(Bos Taurus)
Mammalia EIF2C1 35
  • 95.33 (n)
  • 99.88 (a)
EIF2C1 36
  • 97 (a)
OneToOne
dog
(Canis familiaris)
Mammalia AGO1 35
  • 95.64 (n)
  • 100 (a)
AGO1 36
  • 100 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Ago1 35
  • 93.5 (n)
  • 100 (a)
Ago1 16
Ago1 36
  • 100 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia AGO1 36
  • 100 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia AGO1 36
  • 93 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Ago1 35
  • 93.39 (n)
  • 99.88 (a)
chicken
(Gallus gallus)
Aves AGO1 36
  • 100 (a)
OneToOne
EIF2C1 35
  • 83.94 (n)
  • 99.88 (a)
lizard
(Anolis carolinensis)
Reptilia AGO1 36
  • 100 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia ago4 35
  • 80.98 (n)
  • 98.25 (a)
zebrafish
(Danio rerio)
Actinopterygii AGO1 36
  • 96 (a)
OneToOne
LOC570775 35
  • 80.71 (n)
  • 96.92 (a)
Alicante grape
(Vitis vinifera)
eudicotyledons Vvi.11707 35
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.5272 35
Species with no ortholog for AGO1:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for AGO1 Gene

ENSEMBL:
Gene Tree for AGO1 (if available)
TreeFam:
Gene Tree for AGO1 (if available)

Paralogs for AGO1 Gene

Paralogs for AGO1 Gene

Selected SIMAP similar genes for AGO1 Gene using alignment to 2 proteins:

genes like me logo Genes that share paralogs with AGO1: view

Variants for AGO1 Gene

Sequence variations from dbSNP and Humsavar for AGO1 Gene

SNP ID Clin Chr 01 pos Sequence Context AA Info Type MAF
rs140864 -- 35,926,061(-) TGCTC(-/TTC)AAGTT cds-indel
rs581459 -- 35,909,509(+) TTGCC(C/T)GGAGT intron-variant
rs595055 -- 35,914,532(-) AAAGA(A/G)AGACA intron-variant
rs595961 -- 35,902,179(+) CACCT(A/G)GGCGC intron-variant
rs619613 -- 35,913,169(-) ggtgg(C/T)gggcg intron-variant

Relevant External Links for AGO1 Gene

HapMap Linkage Disequilibrium report
AGO1
Human Gene Mutation Database (HGMD)
AGO1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Structural Variations from Database of Genomic Variants (DGV) for AGO1 Gene

Disorders for AGO1 Gene

No disorders were found for AGO1 Gene.

No data available for UniProtKB/Swiss-Prot for AGO1 Gene

Publications for AGO1 Gene

  1. Translation repression in human cells by microRNA-induced gene silencing requires RCK/p54. (PMID: 16756390) Chu C.-Y. … Rana T.M. (PLoS Biol. 2006) 3 4 23
  2. Human eukaryotic initiation factor EIF2C1 gene: cDNA sequence, genomic organization, localization to chromosomal bands 1p34-p35, and expression. (PMID: 10534406) Koesters R. … Briner J. (Genomics 1999) 2 3 4
  3. Identification of eight members of the Argonaute family in the human genome. (PMID: 12906857) Sasaki T. … Shimizu N. (Genomics 2003) 2 3
  4. Structural basis for overhang-specific small interfering RNA recognition by the PAZ domain. (PMID: 15152257) Ma J.-B. … Patel D.J. (Nature 2004) 3 4
  5. Human Argonaute2 mediates RNA cleavage targeted by miRNAs and siRNAs. (PMID: 15260970) Meister G. … Tuschl T. (Mol. Cell 2004) 3 4

Products for AGO1 Gene

  • Addgene plasmids for AGO1

Sources for AGO1 Gene

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