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Aliases for AGMO Gene

Aliases for AGMO Gene

  • Alkylglycerol Monooxygenase 2 3
  • Transmembrane Protein 195 2 3 4
  • TMEM195 3 4 6
  • Glyceryl-Ether Monooxygenase 3
  • EC 1.14.16.5 4

External Ids for AGMO Gene

Previous HGNC Symbols for AGMO Gene

  • TMEM195

Summaries for AGMO Gene

Entrez Gene Summary for AGMO Gene

  • The protein encoded by this gene is a tetrahydrobiopterin- and iron-dependent enzyme that cleaves the ether bond of alkylglycerols. Sequence comparisons distinguish this protein as forming a third, distinct class of tetrahydrobiopterin-dependent enzymes. Variations in this gene have been associated with decreased glucose-stimulated insulin response, type 2 diabetes, and susceptibility to intracranial aneurysms. [provided by RefSeq, Aug 2012]

GeneCards Summary for AGMO Gene

AGMO (Alkylglycerol Monooxygenase) is a Protein Coding gene. GO annotations related to this gene include iron ion binding and glyceryl-ether monooxygenase activity.

UniProtKB/Swiss-Prot for AGMO Gene

  • Glyceryl-ether monooxygenase that cleaves the O-alkyl bond of ether lipids. Ether lipids are essential components of brain membranes.

No data available for Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for AGMO Gene

Genomics for AGMO Gene

Genomic Location for AGMO Gene

Start:
15,200,318 bp from pter
End:
15,562,015 bp from pter
Size:
361,698 bases
Orientation:
Minus strand

Genomic View for AGMO Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for AGMO Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for AGMO Gene

No data available for Regulatory Elements for AGMO Gene

Proteins for AGMO Gene

  • Protein details for AGMO Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q6ZNB7-ALKMO_HUMAN
    Recommended name:
    Alkylglycerol monooxygenase
    Protein Accession:
    Q6ZNB7
    Secondary Accessions:
    • A4D114
    • A6NCH5

    Protein attributes for AGMO Gene

    Size:
    445 amino acids
    Molecular mass:
    51500 Da
    Cofactor:
    Name=Fe cation; Xref=ChEBI:CHEBI:24875;
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=EAL24290.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};

neXtProt entry for AGMO Gene

Proteomics data for AGMO Gene at MOPED

Post-translational modifications for AGMO Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for AGMO Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for AGMO Gene

Domains for AGMO Gene

Gene Families for AGMO Gene

HGNC:
  • FATHD :Fatty acid hydroxylase domain containing

Protein Domains for AGMO Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for AGMO Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q6ZNB7

UniProtKB/Swiss-Prot:

ALKMO_HUMAN :
  • Q6ZNB7
Family:
  • Belongs to the sterol desaturase family. TMEM195 subfamily.
genes like me logo Genes that share domains with AGMO: view

Function for AGMO Gene

Molecular function for AGMO Gene

UniProtKB/Swiss-Prot BiophysicochemicalProperties: Kinetic parameters: KM=11 uM for 1-O pyrenedecyl glycerol (in presence of ALDH3A2) {ECO:0000269 PubMed:20643956}; KM=2.58 uM for tetrahydrobiopterin (in presence of ALDH3A2) {ECO:0000269 PubMed:20643956};
UniProtKB/Swiss-Prot CatalyticActivity: 1-alkyl-sn-glycerol + tetrahydrobiopterin + O(2) = 1-O-alkyl-sn-glycerol + dihydrobiopterin + H(2)O.
UniProtKB/Swiss-Prot Function: Glyceryl-ether monooxygenase that cleaves the O-alkyl bond of ether lipids. Ether lipids are essential components of brain membranes.

Enzyme Numbers (IUBMB) for AGMO Gene

Gene Ontology (GO) - Molecular Function for AGMO Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005506 iron ion binding IMP 20643956
GO:0016491 oxidoreductase activity --
GO:0050479 glyceryl-ether monooxygenase activity IDA 20643956
genes like me logo Genes that share ontologies with AGMO: view

Phenotypes for AGMO Gene

GenomeRNAi human phenotypes for AGMO:
genes like me logo Genes that share phenotypes with AGMO: view

Animal Model Products

CRISPR Products

No data available for Animal Models , miRNA , Transcription Factor Targeting and HOMER Transcription for AGMO Gene

Localization for AGMO Gene

Subcellular locations from UniProtKB/Swiss-Prot for AGMO Gene

Endoplasmic reticulum membrane; Multi-pass membrane protein.

Gene Ontology (GO) - Cellular Components for AGMO Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005783 endoplasmic reticulum IDA 20643956
GO:0005789 endoplasmic reticulum membrane IEA --
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with AGMO: view

No data available for Subcellular locations from COMPARTMENTS for AGMO Gene

Pathways for AGMO Gene

SuperPathways for AGMO Gene

No Data Available

Interacting Proteins for AGMO Gene

Gene Ontology (GO) - Biological Process for AGMO Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006633 fatty acid biosynthetic process IEA --
GO:0006643 membrane lipid metabolic process IDA 20643956
GO:0046485 ether lipid metabolic process IDA 20643956
GO:0055114 oxidation-reduction process IEA --
genes like me logo Genes that share ontologies with AGMO: view

No data available for Pathways by source for AGMO Gene

Transcripts for AGMO Gene

mRNA/cDNA for AGMO Gene

(2) Additional mRNA sequences :
(14) Selected AceView cDNA sequences:
(5) REFSEQ mRNAs :
(4) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for AGMO Gene

Alkylglycerol monooxygenase:
Representative Sequences:

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for AGMO

Primer Products

  • OriGene qSTAR qPCR primer pairs in human,mouse,rat for AGMO

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for AGMO Gene

No ASD Table

Relevant External Links for AGMO Gene

GeneLoc Exon Structure for
AGMO
ECgene alternative splicing isoforms for
AGMO

Expression for AGMO Gene

mRNA expression in normal human tissues for AGMO Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for AGMO Gene

This gene is overexpressed in Liver (27.8).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for AGMO Gene

SOURCE GeneReport for Unigene cluster for AGMO Gene Hs.670634

genes like me logo Genes that share expressions with AGMO: view

In Situ Assay Products

No data available for mRNA Expression by UniProt/SwissProt for AGMO Gene

Orthologs for AGMO Gene

This gene was present in the common ancestor of animals.

Orthologs for AGMO Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia AGMO 35
  • 99.25 (n)
  • 99.33 (a)
AGMO 36
  • 99 (a)
OneToOne
cow
(Bos Taurus)
Mammalia AGMO 35
  • 87.72 (n)
  • 88.09 (a)
AGMO 36
  • 88 (a)
OneToOne
dog
(Canis familiaris)
Mammalia AGMO 35
  • 89.62 (n)
  • 91.42 (a)
AGMO 36
  • 91 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Agmo 35
  • 84.64 (n)
  • 83.37 (a)
Agmo 16
Agmo 36
  • 83 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia AGMO 36
  • 72 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia -- 36
  • 70 (a)
OneToMany
-- 36
  • 74 (a)
OneToMany
-- 36
  • 88 (a)
OneToMany
-- 36
  • 68 (a)
OneToMany
-- 36
  • 69 (a)
OneToMany
rat
(Rattus norvegicus)
Mammalia Agmo 35
  • 83.07 (n)
  • 83.15 (a)
chicken
(Gallus gallus)
Aves AGMO 35
  • 70.22 (n)
  • 65.2 (a)
AGMO 36
  • 55 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia AGMO 36
  • 72 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia agmo 35
  • 66.9 (n)
  • 65.97 (a)
zebrafish
(Danio rerio)
Actinopterygii agmo 35
  • 61.44 (n)
  • 59.55 (a)
agmo 36
  • 57 (a)
OneToOne
worm
(Caenorhabditis elegans)
Secernentea agmo-1 35
  • 48.88 (n)
  • 39.69 (a)
agmo-1 36
  • 31 (a)
OneToOne
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 48 (a)
OneToOne
Species with no ortholog for AGMO:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for AGMO Gene

ENSEMBL:
Gene Tree for AGMO (if available)
TreeFam:
Gene Tree for AGMO (if available)

Paralogs for AGMO Gene

Selected SIMAP similar genes for AGMO Gene using alignment to 3 proteins:

genes like me logo Genes that share paralogs with AGMO: view

No data available for Paralogs for AGMO Gene

Variants for AGMO Gene

Sequence variations from dbSNP and Humsavar for AGMO Gene

SNP ID Clin Chr 07 pos Sequence Context AA Info Type MAF
rs763 -- 15,463,242(-) ACTTA(C/T)GACAA intron-variant
rs916943 -- 15,554,143(+) ATTTT(C/T)AAAAA intron-variant
rs978897 -- 15,558,531(+) CTTAA(A/G)GGGGA intron-variant
rs978898 -- 15,558,818(+) TAGAT(A/G)TTTAA intron-variant
rs978899 -- 15,558,843(+) TTTTT(A/T)AAAAT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for AGMO Gene

Variant ID Type Subtype PubMed ID
dgv2062e1 CNV Complex 17122850
nsv522976 CNV Gain 19592680
esv2670331 CNV Deletion 23128226
dgv7210n71 CNV Loss 21882294
nsv887726 CNV Loss 21882294
esv2676612 CNV Deletion 23128226
esv2668496 CNV Deletion 23128226
esv2673644 CNV Deletion 23128226
esv2673770 CNV Deletion 23128226
nsv887727 CNV Gain 21882294
esv2734043 CNV Deletion 23290073
nsv366752 CNV Loss 16902084
esv1002080 CNV Deletion 20482838
nsv517723 CNV Loss 19592680
nsv524952 CNV Loss 19592680
nsv437537 CNV Loss 16327808
esv2662398 CNV Deletion 23128226
esv26270 CNV Loss 19812545
nsv518175 CNV Loss 19592680
nsv524706 CNV Loss 19592680
nsv887728 CNV Loss 21882294
nsv887729 CNV Loss 21882294
esv2734044 CNV Deletion 23290073
esv259539 OTHER Complex 20981092
dgv7211n71 CNV Gain 21882294
dgv410n21 CNV Loss 19592680
dgv7212n71 CNV Loss 21882294
nsv887733 CNV Gain+Loss 21882294
esv2734045 CNV Deletion 23290073
esv2734046 CNV Deletion 23290073
esv1274113 CNV Insertion 17803354
nsv523199 CNV Gain 19592680

Relevant External Links for AGMO Gene

HapMap Linkage Disequilibrium report
AGMO
Human Gene Mutation Database (HGMD)
AGMO

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for AGMO Gene

Disorders for AGMO Gene

No disorders were found for AGMO Gene.

No data available for UniProtKB/Swiss-Prot for AGMO Gene

Publications for AGMO Gene

  1. Identification of the gene encoding alkylglycerol monooxygenase defines a third class of tetrahydrobiopterin-dependent enzymes. (PMID: 20643956) Watschinger K. … Werner E.R. (Proc. Natl. Acad. Sci. U.S.A. 2010) 2 3 4
  2. Human chromosome 7: DNA sequence and biology. (PMID: 12690205) Scherer S.W. … Tsui L.-C. (Science 2003) 3 4
  3. New genetic loci implicated in fasting glucose homeostasis and their impact on type 2 diabetes risk. (PMID: 20081858) Dupuis J. … Barroso I. (Nat. Genet. 2010) 3
  4. Variants at DGKB/TMEM195, ADRA2A, GLIS3 and C2CD4B loci are associated with reduced glucose-stimulated beta cell function in middle-aged Danish people. (PMID: 20419449) Boesgaard T.W. … Pedersen O. (Diabetologia 2010) 3
  5. Evaluating the discriminative power of multi-trait genetic risk scores for type 2 diabetes in a northern Swedish population. (PMID: 20571754) Fontaine-Bisson B. … Franks P.W. (Diabetologia 2010) 3

Products for AGMO Gene

Sources for AGMO Gene

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