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AGMO Gene

protein-coding   GIFtS: 40
GCID: GC07M015239

Alkylglycerol Monooxygenase

(Previous name: transmembrane protein 195)
(Previous symbol: TMEM195)
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Alkylglycerol Monooxygenase1 2
TMEM1951 2 3 5
Transmembrane Protein 1951 2 3
Glyceryl-Ether Monooxygenase2
EC 1.14.16.53

External Ids:    HGNC: 337841   Entrez Gene: 3926362   Ensembl: ENSG000001875467   OMIM: 6137385   UniProtKB: Q6ZNB73   

Export aliases for AGMO gene to outside databases


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for AGMO Gene:
The protein encoded by this gene is a tetrahydrobiopterin- and iron-dependent enzyme that cleaves the ether bond
of alkylglycerols. Sequence comparisons distinguish this protein as forming a third, distinct class of
tetrahydrobiopterin-dependent enzymes. Variations in this gene have been associated with decreased
glucose-stimulated insulin response, type 2 diabetes, and susceptibility to intracranial aneurysms. (provided by
RefSeq, Aug 2012)

GeneCards Summary for AGMO Gene:
AGMO (alkylglycerol monooxygenase) is a protein-coding gene. Diseases associated with AGMO include intracranial aneurysm, and tuberculosis. GO annotations related to this gene include glyceryl-ether monooxygenase activity and iron ion binding.

UniProtKB/Swiss-Prot: ALKMO_HUMAN, Q6ZNB7
Function: Glyceryl-ether monooxygenase that cleaves the O-alkyl bond of ether lipids. Ether lipids are essential
components of brain membranes




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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Regulatory elements:
   Search for regulatory transcription factor binding sites for AGMO
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidAGMO promoter sequence
   Search Chromatin IP Primers for AGMO

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat AGMO


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 7p21.2   Ensembl cytogenetic band:  7p21.2   HGNC cytogenetic band: 7p21.1

AGMO Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
AGMO gene location

GeneLoc information about chromosome 7         GeneLoc Exon Structure

GeneLoc location for GC07M015239:  view genomic region     (about GC identifiers)

Start:
15,239,943 bp from pter      End:
15,601,640 bp from pter
Size:
361,698 bases      Orientation:
minus strand

1 alternative location:
Chr7-,CRA_TCAG 15,291,248-15,654,751     

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
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UniProtKB/Swiss-Prot: ALKMO_HUMAN, Q6ZNB7 (See protein sequence)
Recommended Name: Alkylglycerol monooxygenase  
Size: 445 amino acids; 51500 Da
Cofactor: Iron (Probable)
Sequence caution: Sequence=EAL24290.1; Type=Erroneous gene model prediction;
Secondary accessions: A4D114 A6NCH5

Explore the universe of human proteins at neXtProt for AGMO: NX_Q6ZNB7

Explore proteomics data for AGMO at MOPED

Post-translational modifications: 

  • Modification sites at neXtProt
  • Modification sites at PhosphoSitePlus

  • See AGMO Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_001004320.1  
    ENSEMBL proteins: 
     ENSP00000341662   ENSP00000385742   ENSP00000394412  

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    Cloud-Clone Corp. CLIAs for AGMO


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    FATHD: Fatty acid hydroxylase domain containing

    1 InterPro protein domain:
     IPR006694 Fatty_acid_hydroxylase

    Graphical View of Domain Structure for InterPro Entry Q6ZNB7

    ProtoNet protein and cluster: Q6ZNB7

    UniProtKB/Swiss-Prot: ALKMO_HUMAN, Q6ZNB7
    Similarity: Belongs to the sterol desaturase family. TMEM195 subfamily


    AGMO for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: ALKMO_HUMAN, Q6ZNB7
    Function: Glyceryl-ether monooxygenase that cleaves the O-alkyl bond of ether lipids. Ether lipids are essential
    components of brain membranes
    Catalytic activity: 1-alkyl-sn-glycerol + tetrahydrobiopterin + O(2) = 1-O-alkyl-sn-glycerol + dihydrobiopterin +
    H(2)O
    Biophysicochemical properties: Kinetic parameters: KM=11 uM for 1-O pyrenedecyl glycerol (in presence of ALDH3A2);
    KM=2.58 uM for tetrahydrobiopterin (in presence of ALDH3A2);

         Enzyme Number (IUBMB): EC 1.14.16.51

         Gene Ontology (GO): 3 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005506iron ion binding IMP--
    GO:0016491oxidoreductase activity ----
    GO:0050479glyceryl-ether monooxygenase activity IDA--
         
    AGMO for ontologies           About GeneDecksing


    Phenotypes:
         1 GenomeRNAi human phenotype for AGMO:
     Synthetic lethal with c-Myc af 

    Animal Models:
       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for AGMO
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    5 qRT-PCR Assays for microRNAs that regulate AGMO:
    hsa-miR-511 hsa-miR-653 hsa-miR-1303 hsa-miR-590-3p hsa-miR-3138
    SwitchGear 3'UTR luciferase reporter plasmidAGMO 3' UTR sequence
    Inhib. RNA
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    Predesigned siRNA for gene silencing in human, mouse, rat AGMO

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    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    ALKMO_HUMAN, Q6ZNB7: Endoplasmic reticulum membrane; Multi-pass membrane protein

    Gene Ontology (GO): 3 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005783endoplasmic reticulum IDA--
    GO:0005789endoplasmic reticulum membrane IEA--
    GO:0016021integral component of membrane IEA--

    AGMO for ontologies           About GeneDecksing


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for AGMO
    Interactions:

        Search GeneGlobe Interaction Network for AGMO

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for AGMO (ENSP000003416624) via UniProtKB, MINT, STRING, and/or I2D (see all 68)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    C14orf1ENSP000002563194STRING: ENSP00000256319
    FDFT1ENSP000002205844STRING: ENSP00000220584
    LSSENSP000003487624STRING: ENSP00000348762
    SQLEENSP000002658964STRING: ENSP00000265896
    SIGMAR1ENSP000002770104STRING: ENSP00000277010
    About this table

    Gene Ontology (GO): 4 biological process terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006633fatty acid biosynthetic process IEA--
    GO:0006643membrane lipid metabolic process IDA--
    GO:0046485ether lipid metabolic process IDA--
    GO:0055114oxidation-reduction process ----

    AGMO for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for AGMO (ALKMO)



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
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    REFSEQ mRNAs for AGMO gene: 
    NM_001004320.1  

    4 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000342526(uc003stb.1) ENST00000407277 ENST00000418075 ENST00000498264

    miRNA
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    5 qRT-PCR Assays for microRNAs that regulate AGMO:
    hsa-miR-511 hsa-miR-653 hsa-miR-1303 hsa-miR-590-3p hsa-miR-3138
    SwitchGear 3'UTR luciferase reporter plasmidAGMO 3' UTR sequence
    Inhib. RNA
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    Predesigned siRNA for gene silencing in human, mouse, rat AGMO
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    Primer
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    Pre-validated RT2 qPCR Primer Assay in human, mouse / rat AGMO
      QuantiTect SYBR Green Assays in human, mouse, rat AGMO
      QuantiFast Probe-based Assays in human, mouse, rat AGMO

    14 AceView cDNA sequences:

    AK131284 NM_001004320 BG184006 BG199009 BG184008 BG210858 BG215242 BG209478 
    BG202090 BG221368 BG057477 BG192913 BG212574 BG215241 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    AGMO expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: AAACAACTCA
    AGMO Expression
    About this image


    AGMO expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 6) fully expand
     
     Epithelial Cells
             Duct Cells Pancreatic Ducts
     
     Heart (Cardiovascular System)
             Mature Cardiac Fibroblasts Myocardium
     
     Pancreas (Endocrine System)
             Duct Cells Pancreatic Ducts
     
     Fibroblasts
             Mature Cardiac Fibroblasts Myocardium
     
     Skeletal Muscle (Muscoskeletal System)
             Muscle Progenitor Cells Thoracic Ventrolateral Dermomyotome Lip
    AGMO Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    AGMO Protein Expression
        Custom PCR Arrays for AGMO
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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for AGMO

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of animals.

    Orthologs for AGMO gene from Selected species (see all 13)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Agmo1 , 5 alkylglycerol monooxygenase1, 5 84.64(n)1
    83.37(a)1
      12 (16.84 cM)5
    3196601  NM_178767.51  NP_848882.21 
     372416415 
    chicken
    (Gallus gallus)
    Aves AGMO1 alkylglycerol monooxygenase 70.22(n)
    65.2(a)
      772374  XM_001235520.3  XP_001235521.3 
    lizard
    (Anolis carolinensis)
    Reptilia AGMO6
    alkylglycerol monooxygenase
    72(a)
    1 ↔ 1
    6(26886307-26977887)
    tropical clawed frog
    (Xenopus tropicalis)
    Amphibia agmo1 alkylglycerol monooxygenase 66.9(n)
    65.97(a)
      496770  NM_001011313.1  NP_001011313.1 
    zebrafish
    (Danio rerio)
    Actinopterygii agmo1 alkylglycerol monooxygenase 61.44(n)
    59.55(a)
      405819  NM_212883.1  NP_998048.1 
    worm
    (Caenorhabditis elegans)
    Secernentea agmo-11 agmo-1 48.88(n)
    39.69(a)
      176695  NM_067263.5  NP_499664.2 


    ENSEMBL Gene Tree for AGMO (if available)
    TreeFam Gene Tree for AGMO (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for AGMO gene
    1 SIMAP similar gene for AGMO using alignment to 3 protein entries:     ALKMO_HUMAN (see all proteins):
    LOC389466

    AGMO for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for AGMO (see all 9725)    About this table    
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 7 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1380556791,2
    C--15239478(+) AGAATG/TTGTTG 1 -- ds50010--------
    rs1495058491,2
    --15239568(+) TTCACA/GTAGAC 1 -- ds50010--------
    rs125313861,2
    C,F,A,H--15239663(+) TCAGGC/TTCCTT 1 -- ds500110Minor allele frequency- T:0.07NS EA NA WA 664
    rs1837524211,2
    --15239718(+) TTTTTC/TTTAGT 1 -- ds50010--------
    rs1153111501,2
    C--15239729(+) ACATGC/TGTCTT 1 -- ds50010--------
    rs788023281,2
    C,F--15239750(+) AATTAT/CTAAAT 1 -- ds50011Minor allele frequency- C:0.14NA 120
    rs113159781,2
    C--15239821(+) AAAGA-/TTTTTT 1 -- ds50012Minor allele frequency- T:0.25NA 4
    rs1130688871,2
    C--15239829(+) TTTTTC/TTAACT 1 -- ds50010--------
    rs761205881,2
    C--15239849(+) TCTCAT/GTCTTT 1 -- ds50014Minor allele frequency- G:0.12CSA WA NA EA 360
    rs125314781,2
    C,F,A,H--15239894(+) CTAACG/AAAACA 1 -- ds500121Minor allele frequency- A:0.05NS EA NA WA 2392

    HapMap Linkage Disequilibrium report for AGMO (15239943 - 15489943 bp, first 250kb of AGMO)

    Structural Variations
         Database of Genomic Variants (DGV) Selected variations for AGMO (see all 32):    About this table    
    Variant IDTypeSubtypePubMed ID
    esv2673644CNV Deletion23128226
    esv2676612CNV Deletion23128226
    esv2734043CNV Deletion23290073
    esv2670331CNV Deletion23128226
    esv2673770CNV Deletion23128226
    esv2734045CNV Deletion23290073
    esv2662398CNV Deletion23128226
    esv2734044CNV Deletion23290073
    esv2668496CNV Deletion23128226
    esv2734046CNV Deletion23290073

    Site Specific Mutation Identification with PCR Assays
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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 613738    OMIM disorders: --

    4 diseases for AGMO:    
    About MalaCards
    intracranial aneurysm    tuberculosis    obesity    pancreatitis


    AGMO for disorders           About GeneDecksing


    Export disorders for AGMO gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for AGMO gene, integrated from 10 sources (see all 12):
    (articles sorted by number of sources associating them with AGMO)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Identification of the gene encoding alkylglycerol monooxygenase defines a third class of tetrahydrobiopterin-dependent enzymes. (PubMed id 20643956)1, 2, 3 Watschinger K.... Werner E.R. (Proc. Natl. Acad. Sci. U.S.A. 2010)
    2. Human chromosome 7: DNA sequence and biology. (PubMed id 12690205)1, 2 Scherer S.W.... Tsui L.-C. (Science 2003)
    3. Genome-wide screen for metabolic syndrome susceptibility Loci reveals strong lipid gene contribution but no evidence for common genetic basis for clustering of metabolic syndrome traits. (PubMed id 22399527)1 Kristiansson K....Salomaa V. (Circ Cardiovasc Genet 2012)
    4. Novel genetic loci identified for the pathophysiology of childhood obesity in the Hispanic population. (PubMed id 23251661)1 Comuzzie A.G....Butte N.F. (PLoS ONE 2012)
    5. Catalytic residues and a predicted structure of tetrahydrobiopterin-dependent alkylglycerol mono-oxygenase. (PubMed id 22220568)1 Watschinger K....Werner E.R. (Biochem. J. 2012)
    6. Genome-wide association study to identify genetic variants present in Japanese patients harboring intracranial aneurysms. (PubMed id 20613766)1 Akiyama K....Inoue I. (J. Hum. Genet. 2010)
    7. Evaluating the discriminative power of multi-trait genetic risk scores for type 2 diabetes in a northern Swedish population. (PubMed id 20571754)1 Fontaine-Bisson B....Franks P.W. (Diabetologia 2010)
    8. Variants at DGKB/TMEM195, ADRA2A, GLIS3 and C2CD4B loci are associated with reduced glucose-stimulated beta cell function in middle-aged Danish people. (PubMed id 20419449)1 Boesgaard T.W....Pedersen O. (Diabetologia 2010)
    9. New genetic loci implicated in fasting glucose homeostasis and their impact on type 2 diabetes risk. (PubMed id 20081858)1 Dupuis J....Barroso I. (Nat. Genet. 2010)
    10. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)2 Gerhard D.S.... Malek J. (Genome Res. 2004)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 392636 HGNC: 33784 AceView: FLJ16237.1 Ensembl:ENSG00000187546 euGenes: HUgn392636
    ECgene: AGMO H-InvDB: AGMO

    (According to HUGE)
    About This Section

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    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for AGMO Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for AGMO gene:
    Search GeneIP for patents involving AGMO

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript, and ESI BIO, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
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