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Aliases for AGMO Gene

Aliases for AGMO Gene

  • Alkylglycerol Monooxygenase 2 3
  • Transmembrane Protein 195 2 3 4
  • TMEM195 3 4
  • Glyceryl-Ether Monooxygenase 3
  • EC 1.14.16.5 4

External Ids for AGMO Gene

Previous HGNC Symbols for AGMO Gene

  • TMEM195

Summaries for AGMO Gene

Entrez Gene Summary for AGMO Gene

  • The protein encoded by this gene is a tetrahydrobiopterin- and iron-dependent enzyme that cleaves the ether bond of alkylglycerols. Sequence comparisons distinguish this protein as forming a third, distinct class of tetrahydrobiopterin-dependent enzymes. Variations in this gene have been associated with decreased glucose-stimulated insulin response, type 2 diabetes, and susceptibility to intracranial aneurysms. [provided by RefSeq, Aug 2012]

GeneCards Summary for AGMO Gene

AGMO (Alkylglycerol Monooxygenase) is a Protein Coding gene. Among its related pathways are Metabolism and Regulation of lipid metabolism by Peroxisome proliferator-activated receptor alpha (PPARalpha). GO annotations related to this gene include oxidoreductase activity and glyceryl-ether monooxygenase activity.

UniProtKB/Swiss-Prot for AGMO Gene

  • Glyceryl-ether monooxygenase that cleaves the O-alkyl bond of ether lipids. Ether lipids are essential components of brain membranes.

No data available for Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for AGMO Gene

Genomics for AGMO Gene

Genomic Location for AGMO Gene

Chromosome:
7
Start:
15,159,124 bp from pter
End:
15,562,015 bp from pter
Size:
402,892 bases
Orientation:
Minus strand

Genomic View for AGMO Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for AGMO Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for AGMO Gene

No data available for Regulatory Elements for AGMO Gene

Proteins for AGMO Gene

  • Protein details for AGMO Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q6ZNB7-ALKMO_HUMAN
    Recommended name:
    Alkylglycerol monooxygenase
    Protein Accession:
    Q6ZNB7
    Secondary Accessions:
    • A4D114
    • A6NCH5

    Protein attributes for AGMO Gene

    Size:
    445 amino acids
    Molecular mass:
    51500 Da
    Cofactor:
    Name=Fe cation; Xref=ChEBI:CHEBI:24875;
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=EAL24290.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};

neXtProt entry for AGMO Gene

Proteomics data for AGMO Gene at MOPED

Post-translational modifications for AGMO Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for AGMO Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for AGMO Gene

Domains & Families for AGMO Gene

Gene Families for AGMO Gene

Protein Domains for AGMO Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for AGMO Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q6ZNB7

UniProtKB/Swiss-Prot:

ALKMO_HUMAN :
  • Belongs to the sterol desaturase family. TMEM195 subfamily.
Family:
  • Belongs to the sterol desaturase family. TMEM195 subfamily.
genes like me logo Genes that share domains with AGMO: view

Function for AGMO Gene

Molecular function for AGMO Gene

UniProtKB/Swiss-Prot BiophysicochemicalProperties:
Kinetic parameters: KM=11 uM for 1-O pyrenedecyl glycerol (in presence of ALDH3A2) {ECO:0000269 PubMed:20643956}; KM=2.58 uM for tetrahydrobiopterin (in presence of ALDH3A2) {ECO:0000269 PubMed:20643956};
UniProtKB/Swiss-Prot CatalyticActivity:
1-alkyl-sn-glycerol + tetrahydrobiopterin + O(2) = 1-O-alkyl-sn-glycerol + dihydrobiopterin + H(2)O.
UniProtKB/Swiss-Prot Function:
Glyceryl-ether monooxygenase that cleaves the O-alkyl bond of ether lipids. Ether lipids are essential components of brain membranes.

Enzyme Numbers (IUBMB) for AGMO Gene

Gene Ontology (GO) - Molecular Function for AGMO Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005506 iron ion binding IMP 20643956
GO:0016491 oxidoreductase activity --
GO:0050479 glyceryl-ether monooxygenase activity IDA 20643956
genes like me logo Genes that share ontologies with AGMO: view

Phenotypes for AGMO Gene

GenomeRNAi human phenotypes for AGMO:
genes like me logo Genes that share phenotypes with AGMO: view

Animal Model Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for AGMO

In Situ Assay Products

Flow Cytometry Products

No data available for Animal Models , Transcription Factor Targets and HOMER Transcription for AGMO Gene

Localization for AGMO Gene

Subcellular locations from UniProtKB/Swiss-Prot for AGMO Gene

Endoplasmic reticulum membrane; Multi-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for AGMO Gene COMPARTMENTS Subcellular localization image for AGMO gene
Compartment Confidence
endoplasmic reticulum 5

Gene Ontology (GO) - Cellular Components for AGMO Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005783 endoplasmic reticulum IDA 20643956
GO:0005789 endoplasmic reticulum membrane TAS --
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with AGMO: view

Pathways & Interactions for AGMO Gene

genes like me logo Genes that share pathways with AGMO: view

Interacting Proteins for AGMO Gene

Gene Ontology (GO) - Biological Process for AGMO Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006633 fatty acid biosynthetic process IEA --
GO:0006643 membrane lipid metabolic process IDA 20643956
GO:0019432 triglyceride biosynthetic process TAS --
GO:0044255 cellular lipid metabolic process TAS --
GO:0044281 small molecule metabolic process TAS --
genes like me logo Genes that share ontologies with AGMO: view

No data available for SIGNOR curated interactions for AGMO Gene

Drugs & Compounds for AGMO Gene

(1) Drugs for AGMO Gene - From: HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
dihydrobiopterin Experimental Pharma 0

(3) Additional Compounds for AGMO Gene - From: HMDB

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
L-erythro-tetrahydrobiopterin
oxygen
  • Dioxygen
  • Molecular oxygen
  • O2
  • Oxygen
  • Oxygen molecule
7782-44-7
Water
  • Dihydrogen oxide
  • Steam
7732-18-5
genes like me logo Genes that share compounds with AGMO: view

Transcripts for AGMO Gene

mRNA/cDNA for AGMO Gene

(5) REFSEQ mRNAs :
(2) Additional mRNA sequences :
(14) Selected AceView cDNA sequences:
(4) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for AGMO Gene

Alkylglycerol monooxygenase:
Representative Sequences:

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for AGMO

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for AGMO Gene

No ASD Table

Relevant External Links for AGMO Gene

GeneLoc Exon Structure for
AGMO
ECgene alternative splicing isoforms for
AGMO

Expression for AGMO Gene

mRNA expression in normal human tissues for AGMO Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for AGMO Gene

This gene is overexpressed in Liver (x27.8).

Protein differential expression in normal tissues from HIPED for AGMO Gene

This gene is overexpressed in Liver (46.6) and Fetal Liver (22.4).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for AGMO Gene



SOURCE GeneReport for Unigene cluster for AGMO Gene Hs.670634

genes like me logo Genes that share expression patterns with AGMO: view

Protein tissue co-expression partners for AGMO Gene

Primer Products

In Situ Assay Products

No data available for mRNA Expression by UniProt/SwissProt for AGMO Gene

Orthologs for AGMO Gene

This gene was present in the common ancestor of animals.

Orthologs for AGMO Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia AGMO 35
  • 87.72 (n)
  • 88.09 (a)
AGMO 36
  • 88 (a)
OneToOne
dog
(Canis familiaris)
Mammalia AGMO 35
  • 89.62 (n)
  • 91.42 (a)
AGMO 36
  • 91 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Agmo 35
  • 84.64 (n)
  • 83.37 (a)
Agmo 16
Agmo 36
  • 83 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia AGMO 35
  • 99.25 (n)
  • 99.33 (a)
AGMO 36
  • 99 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Agmo 35
  • 83.07 (n)
  • 83.15 (a)
oppossum
(Monodelphis domestica)
Mammalia AGMO 36
  • 72 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia -- 36
  • 70 (a)
OneToMany
-- 36
  • 74 (a)
OneToMany
-- 36
  • 88 (a)
OneToMany
-- 36
  • 68 (a)
OneToMany
-- 36
  • 69 (a)
OneToMany
chicken
(Gallus gallus)
Aves AGMO 35
  • 70.22 (n)
  • 65.2 (a)
AGMO 36
  • 55 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia AGMO 36
  • 72 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia agmo 35
  • 66.9 (n)
  • 65.97 (a)
zebrafish
(Danio rerio)
Actinopterygii agmo 35
  • 61.44 (n)
  • 59.55 (a)
agmo 36
  • 57 (a)
OneToOne
worm
(Caenorhabditis elegans)
Secernentea agmo-1 35
  • 48.88 (n)
  • 39.69 (a)
agmo-1 36
  • 31 (a)
OneToOne
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 48 (a)
OneToOne
Species with no ortholog for AGMO:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for AGMO Gene

ENSEMBL:
Gene Tree for AGMO (if available)
TreeFam:
Gene Tree for AGMO (if available)

Paralogs for AGMO Gene

(1) SIMAP similar genes for AGMO Gene using alignment to 3 proteins:

genes like me logo Genes that share paralogs with AGMO: view

No data available for Paralogs for AGMO Gene

Variants for AGMO Gene

Sequence variations from dbSNP and Humsavar for AGMO Gene

SNP ID Clin Chr 07 pos Sequence Context AA Info Type MAF
rs4721435 -- 15,408,979(+) AGAGA(A/T)AATGC intron-variant
rs4721434 -- 15,408,801(+) GGTTG(C/T)GTGAT intron-variant
rs4721433 -- 15,400,483(+) CATTC(C/T)GTGCT intron-variant
rs4721432 -- 15,392,831(+) acaaa(A/C)aactt intron-variant
rs4721431 -- 15,392,658(+) accac(A/G)cgtgg intron-variant

Structural Variations from Database of Genomic Variants (DGV) for AGMO Gene

Variant ID Type Subtype PubMed ID
dgv2062e1 CNV Complex 17122850
nsv522976 CNV Gain 19592680
esv2670331 CNV Deletion 23128226
dgv7210n71 CNV Loss 21882294
nsv887726 CNV Loss 21882294
esv2676612 CNV Deletion 23128226
esv2668496 CNV Deletion 23128226
esv2673644 CNV Deletion 23128226
esv2673770 CNV Deletion 23128226
nsv887727 CNV Gain 21882294
esv2734043 CNV Deletion 23290073
nsv366752 CNV Loss 16902084
esv1002080 CNV Deletion 20482838
nsv517723 CNV Loss 19592680
nsv524952 CNV Loss 19592680
nsv437537 CNV Loss 16327808
esv2662398 CNV Deletion 23128226
esv26270 CNV Loss 19812545
nsv518175 CNV Loss 19592680
nsv524706 CNV Loss 19592680
nsv887728 CNV Loss 21882294
nsv887729 CNV Loss 21882294
esv2734044 CNV Deletion 23290073
esv259539 OTHER Complex 20981092
dgv7211n71 CNV Gain 21882294
dgv410n21 CNV Loss 19592680
dgv7212n71 CNV Loss 21882294
nsv887733 CNV Gain+Loss 21882294
esv2734045 CNV Deletion 23290073
esv2734046 CNV Deletion 23290073
esv1274113 CNV Insertion 17803354
nsv523199 CNV Gain 19592680

Variation tolerance for AGMO Gene

Residual Variation Intolerance Score: 94.52% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 4.75; 66.54% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for AGMO Gene

HapMap Linkage Disequilibrium report
AGMO
Human Gene Mutation Database (HGMD)
AGMO

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for AGMO Gene

Disorders for AGMO Gene

Relevant External Links for AGMO

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
AGMO
genes like me logo Genes that share disorders with AGMO: view

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for AGMO Gene

Publications for AGMO Gene

  1. Identification of the gene encoding alkylglycerol monooxygenase defines a third class of tetrahydrobiopterin-dependent enzymes. (PMID: 20643956) Watschinger K. … Werner E.R. (Proc. Natl. Acad. Sci. U.S.A. 2010) 2 67
  2. An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome. (PMID: 24275569) Bian Y. … Zou H. (J. Proteomics 2014) 67
  3. Protein interaction network of alternatively spliced isoforms from brain links genetic risk factors for autism. (PMID: 24722188) Corominas R. … Iakoucheva L.M. (Nat. Commun. 2014) 67
  4. Genome-wide screen for metabolic syndrome susceptibility Loci reveals strong lipid gene contribution but no evidence for common genetic basis for clustering of metabolic syndrome traits. (PMID: 22399527) Kristiansson K. … Salomaa V. (Circ Cardiovasc Genet 2012) 67
  5. Novel genetic loci identified for the pathophysiology of childhood obesity in the Hispanic population. (PMID: 23251661) Comuzzie A.G. … Butte N.F. (PLoS ONE 2012) 67

Products for AGMO Gene

Sources for AGMO Gene

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