AGMO Gene
protein-coding GIFtS : 41
GCID: GC07 M015239
alkylglycerol monooxygenase (Previous name: transmembrane protein 195 ) (Previous symbol: TMEM195 )
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Aliasesfor AGMO gene
(According to
1 HGNC ,
2 Entrez Gene ,
3 UniProtKB/Swiss-Prot ,
4 UniProtKB/TrEMBL , 5 OMIM , 6 GeneLoc ,
7 Ensembl ,
8 DME ,
9 miRBase ,
and/or 10 fRNAdb )About This Section Aliases Alkylglycerol Monooxygenase 1 2 TMEM1951 2 3 5 Transmembrane Protein 1951 2 3 FLJ162371 Glyceryl-Ether Monooxygenase2 EC 1.14.16.53
Export aliases for AGMO gene to outside databases
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Summariesfor AGMO gene (According to Entrez Gene ,
Tocris Bioscience ,
Wikipedia's
Gene Wiki ,
PharmGKB ,
UniProtKB/Swiss-Prot ,
and/or
UniProtKB/TrEMBL )
About This Section Entrez Gene summary for AGMO : The protein encoded by this gene is a tetrahydrobiopterin- and iron-dependent enzyme that cleaves the ether bond of alkylglycerols. Sequence comparisons distinguish this protein as forming a third, distinct class of tetrahydrobiopterin-dependent enzymes. Variations in this gene have been associated with decreased glucose-stimulated insulin response, type 2 diabetes, and susceptibility to intracranial aneurysms. (provided by RefSeq, Aug 2012) UniProtKB/Swiss-Prot: ALKMO_HUMAN, Q6ZNB7 Function : Glyceryl-ether monooxygenase that cleaves the O-alkyl bond of ether lipids. Ether lipids are essentialcomponents of brain membranes
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Genomic Viewsfor AGMO gene
(According to
GeneLoc and/or
HGNC , and/or
Entrez Gene (NCBI build 37) ,
and/or miRBase ,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69) ,
Regulatory elements and Epigenetics data according to
QIAGEN ,
SABiosciences , and/or
SwitchGear Genomics )About This Section RefSeq DNA sequence: NC_000007.13 NC_018918.1 NT_007819.17 NT_079592.2 Regulatory elements: Search SABiosciences Regulatory transcription factor binding sites for AGMO Other transcription factors Search SABiosciences Chromatin IP Primers for AGMO Epigenetics: QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat AGMO
Genomic Location: Genomic View : UCSC Golden Path with GeneCards custom track Entrez Gene cytogenetic band: 7p21.2 Ensembl cytogenetic band: 7p21.2 HGNC cytogenetic band: 7p21.1 AGMO Gene in genomic location: bands according to Ensembl, locations according to
(and/or Entrez Gene and/or Ensembl if different) GeneLoc information about chromosome 7 GeneLoc Exon Structure
GeneLoc location for GC07M015239: view genomic region
(about GC identifiers )
Start:
15,239,943 bp from pter
End:
15,601,640 bp from pter
Size:
361,698 bases
Orientation:
minus strand
1 alternative location : Chr 7-,CRA_TCAG 15,291,248-15,654,751
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Proteinsfor AGMO gene
(According to
1 UniProtKB ,
HORDE ,
neXtProt ,
Ensembl ,
and/or Reactome ,
Modification sites according to 2 PhosphoSitePlus ,
Specific Peptides from DME ,
Protein expression images according to data from SPIRE MOPED and PaxDb ,
RefSeq according to NCBI ,
PDB rendering according to OCA and/or Proteopedia ,
Recombinant Proteins
from
EMD Millipore ,
R&D Systems ,
GenScript ,
Enzo Life Sciences ,
OriGene ,
Novus Biologicals ,
Sino Biological ,
ProSpec , and/or
Uscn ,
Biochemical Assays by
EMD Millipore ,
R&D Systems ,
OriGene ,
GenScript ,
Cell Signaling Technology ,
Enzo Life Sciences , and/or
Uscn ,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene ,
Antibodies by
EMD Millipore ,
R&D Systems ,
GenScript ,
Cell Signaling Technology ,
OriGene ,
Novus Biologicals ,
Thermo Fisher Scientific ,
Abcam , and/or
Uscn )
About This Section UniProtKB/Swiss-Prot: ALKMO_HUMAN, Q6ZNB7 (See
protein sequence )Recommended Name: Alkylglycerol monooxygenase Size : 445 amino acids; 51500 Da
Cofactor : Iron (Probable)
Subcellular location : Endoplasmic reticulum membrane; Multi-pass membrane protein
Sequence caution : Sequence=EAL24290.1; Type=Erroneous gene model prediction;
Secondary accessions : A4D114 A6NCH5Explore the universe of human proteins at neXtProt for AGMO: NX_Q6ZNB7 Post-translational modifications:
View modification sites using PhosphoSitePlus 2 View neXtProt modification sites for NX_Q6ZNB7 AGMO Protein expression data from MOPED and PaxDb : About this image REFSEQ proteins: NP_001004320.1 ENSEMBL proteins: ENSP00000341662 ENSP00000385742 ENSP00000394412 Human Recombinant Protein Products for AGMO: Gene Ontology (GO): 3 cellular component terms (GO ID links to tree view) : About this table
GO ID Qualified GO term Evidence PubMed IDs GO:0005783 endoplasmic reticulum
IDA -- GO:0005789 endoplasmic reticulum membrane
IEA -- GO:0016021 integral to membrane
IEA --
AGMO for ontologies About GeneDecksing AGMO Antibody Products: Assay Products for AGMO:
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Protein
Domains / Familiesfor AGMO gene (According to InterPro , ProtoNet ,
UniProtKB , and/or BLOCKS ,
Sets of similar genes according to GeneDecks )
About This Section
AGMO for domains About GeneDecksing 1 InterPro domain/family :
Graphical View of Domain Structure for InterPro Entry Q6ZNB7 ProtoNet protein and cluster: Q6ZNB7
UniProtKB/Swiss-Prot: ALKMO_HUMAN, Q6ZNB7 Similarity : Belongs to the sterol desaturase family. TMEM195 subfamily
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Functionfor AGMO gene
(According to 1 UniProtKB ,
Genatlas ,
LifeMap Discovery™ ,
IUBMB , and/or
2 DME ,
Human phenotypes from GenomeRNAi ,
Animal models from MGI Mar 06 2013,
inGenious Targeting Laboratory ,
bound targets from SABiosciences ,
miRNA Gene Targets from miRTarBase ,
shRNA from
OriGene ,
Sirion Biotech ,
RNAi from
EMD Millipore ,
siRNAs from
OriGene ,
QIAGEN ,
microRNA from QIAGEN ,
Gene Editing from DNA2.0 ,
Sirion Biotech ,
Clones from EMD Millipore ,
OriGene ,
SwitchGear Genomics ,
GenScript ,
Sino Biological ,
DNA2.0 ,
and Vector BioLabs ,
Cell Lines from GenScript ,
LifeMap BioReagents ,
Sirion Biotech ,
In Situ Hybridization Assays from Advanced Cell Diagnostics ,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene .)
About This Section Molecular Function: UniProtKB/Swiss-Prot Summary: ALKMO_HUMAN, Q6ZNB7 Function : Glyceryl-ether monooxygenase that cleaves the O-alkyl bond of ether lipids. Ether lipids are essentialcomponents of brain membranes Catalytic activity : 1-alkyl-sn-glycerol + tetrahydrobiopterin + O(2) = 1-O-alkyl-sn-glycerol + dihydrobiopterin + H(2)OBiophysicochemical properties : Kinetic parameters: KM=11 uM for 1-O pyrenedecyl glycerol (in presence of ALDH3A2);KM=2.58 uM for tetrahydrobiopterin (in presence of ALDH3A2); Enzyme Number (IUBMB): EC 1.14.16.5 1
Gene Ontology (GO): 2 molecular function terms (GO ID links to tree view) : About this table
GO ID Qualified GO term Evidence PubMed IDs GO:0005506 iron ion binding
IMP -- GO:0050479 glyceryl-ether monooxygenase activity
IDA --
AGMO for ontologies About GeneDecksing Phenotypes: 1 GenomeRNAi human phenotype for AGMO :Animal Models: Clone Products: Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human , mouse , rat for AGMO (see all 3 ) OriGene untagged cDNA clones in CMV expression vector in human , mouse , rat for AGMOOriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling GenScript: all cDNA clones in your preferred vector: AGMO (NM_001004320 ) Browse Sino Biological Human cDNA Clones DNA2.0 Custom Codon Optimized Gene
Synthesis Service for AGMO Vector BioLabs ready-to-use adenovirus/AAV for human , mouse , rat AGMO
In Situ Assay Products: Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for AGMO
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Pathways & Interactionsfor AGMO gene
(Pathways according to
EMD Millipore ,
R&D Systems ,
Cell Signaling Technology ,
KEGG ,
PharmGKB ,
BioSystems ,
Reactome ,
Tocris Bioscience ,
GeneGo (Thomson Reuters) ,
QIAGEN ,
and/or UniProtKB ,
Sets of similar genes according to GeneDecks ,
Interaction Networks according to
SABiosciences ,
and/or STRING ,
Interactions according to 1 UniProtKB ,
2 MINT ,
3 I2D , and/or
4 STRING ,
with links to IntAct and
Ensembl ,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene) .
About This Section Interactions: Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for AGMO Gene Ontology (GO): 3 biological process terms (GO ID links to tree view) : About this table
GO ID Qualified GO term Evidence PubMed IDs GO:0006633 fatty acid biosynthetic process
IEA -- GO:0006643 membrane lipid metabolic process
IDA -- GO:0046485 ether lipid metabolic process
IDA --
AGMO for ontologies About GeneDecksing
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Drugs & Compoundsfor AGMO gene (Chemical Compounds according to UniProtKB , Enzo Life Sciences ,
EMD Millipore , Tocris Bioscience
HMDB ,
BitterDB , and/or
Novoseek , and Drugs according to
DrugBank ,
Enzo Life Sciences , and/or
PharmGKB , with drugs/clinical trials/news
search links to CenterWatch )
About This Section Browse Tocris compounds for AGMO Search CenterWatch for drugs/clinical trials and news about AGMO / ALKMO
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Transcriptsfor AGMO gene (Secondary structures according to
fRNAdb ,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank , RefSeq according to Entrez Gene ,
DOTS (version 10), and/or
AceView ,
transcript ids from Ensembl
with links to UCSC ,
exon structure from GeneLoc ,
alternative splicing isoforms according to ASD and/or
ECgene ,
RNAi Products from
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siRNAs from
OriGene ,
QIAGEN ,
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Tagged/untagged cDNA clones from
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SwitchGear Genomics ,
GenScript ,
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Vector BioLabs ,
Primers from
OriGene ,
SABiosciences , and/or
QIAGEN
)About This Section REFSEQ mRNAs for AGMO gene: NM_001004320.1 Unigene Cluster for AGMO:
Alkylglycerol monooxygenase Hs.670634 [show with all ESTs ] Unigene Representative Sequence: AK131284 4 Ensembl transcripts including schematic representations, and UCSC links where relevant : ENST00000342526 (uc003stb.1 ) ENST00000407277 ENST00000418075 ENST00000498264 Clone Products: OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human , mouse , rat for AGMO (see all 3 ) OriGene untagged cDNA clones in CMV expression vector in human , mouse , rat for AGMOOriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling GenScript: all cDNA clones in your preferred vector: AGMO (NM_001004320 ) DNA2.0 Custom Codon Optimized Gene
Synthesis Service for AGMO Vector BioLabs ready-to-use adenovirus/AAV for human , mouse , rat AGMO
Additional cDNA sequence: AK131284.1 BC108676.1
3 DOTS entries : DT.95150240 DT.65285086
DT.100745811 14 AceView cDNA sequences :
NM_001004320 AK131284 BG184006 BG184008 BG199009 BG210858 BG215242 BG209478 BG202090 BG221368 BG215241 BG212574 BG192913 BG057477 GeneLoc Exon Structure
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Expression for AGMO gene
(RNA expression data according to
H-InvDB ,
NONCODE ,
miRBase , and
RNAdb ,
Expression images according to data from
BioGPS ,
Illumina Human BodyMap , and
CGAP
SAGE ,
Sets of similar genes according to GeneDecks ,
in vivo and in vitro expression data from LifeMap Discovery™ ,
plus additional links to
Genevestigator , and/or
SOURCE , and/or
BioGPS , and/or
UniProtKB ,
PCR Arrays from
SABiosciences ,
Primers from
OriGene ,
SABiosciences , and/or
QIAGEN ,
In Situ Hybridization Assays from Advanced Cell Diagnostics )
About This Section AGMO expression in normal human tissues (normalized intensities) See probesets specificity/sensitivity at GeneAnnot About this image BioGPS CGAP TAG: AAACAACTCAAbout this image AGMO expression in embryonic tissues and stem cells Expression by the Database of Embryonic development, Stem cell research, and
Regenerative medicine About this table
See AGMO Protein Expression from SPIRE MOPED and PaxDB SOURCE GeneReport for Unigene cluster: Hs.670634 SABiosciences Custom PCR Arrays for AGMO Primer Products: OriGene genome-wide validated SYBR primer pairs in human , mouse , rat for AGMOBrowse OriGene validated miRNA SYBR primer pairs SABiosciences RT2 qPCR Primer Assay in human , mouse / rat AGMO QIAGEN QuantiTect SYBR Green Assays in human , mouse , rat AGMO QIAGEN QuantiFast Probe-based Assays in human , mouse , rat AGMO In Situ Assay Products: Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for AGMO
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Orthologsfor AGMO gene
(Orthologs according to
1,2 HomoloGene (2 older version, for species not in 1 newer version),
3 euGenes ,
4 SGD
,
5 MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase ,
and/or
6 Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam )
About This Section
This gene was present in the common ancestor of animals.
Orthologs for AGMO gene from 6/19 species (see all 19 ) About this table
ENSEMBL Gene Tree for AGMO (if available)TreeFam Gene Tree for AGMO (if available)
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Paralogsfor AGMO gene (Paralogs according to
1 HomoloGene , 2 Ensembl , and 3 SIMAP , Pseudogenes according to 4 Pseudogene.org Build 68)About This Section --
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Genomic Variantsfor AGMO gene (SNPs/Variants according to the
1 NCBI SNP Database ,
2 Ensembl ,
3 PupaSUITE ,
UniProtKB , and
DNA2.0 ,
Linkage Disequilibrium by HapMap ,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants , Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB) , Blood group antigen gene mutations by BGMUT ,
Resequencing Primers from QIAGEN ,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences )
About This Section
Genomic Data Transcription Related Data Allele Frequencies SNP ID Valid Clinical significance Chr 7 pos Sequence # AA Chg Type More # Allele freq Pop Total sample More
HapMap Linkage Disequilibrium report for AGMO (15239943 - 15489943 bp, first 250kb of AGMO)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions) Database of Genomic Variants (DGV) variations for AGMO: --
SABiosciences Cancer Mutation PCR Assays
QIAGEN SeqTarget long-range PCR primers in human , mouse , rat for resequencing AGMO
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Disorders
/ Diseasesfor AGMO gene
(in which this Gene is Involved, According to MalaCards ,
OMIM, UniProtKB ,
the University of Copenhagen DISEASES
database ,
Genatlas , GeneTests ,
GAD ,
HuGE Navigator ,
and/or TGDB .)
About This Section
AGMO for disorders About GeneDecksing
OMIM gene information: 613738
OMIM disorders : --3 diseases for AGMO : About MalaCards intracranial aneurysm tuberculosis mycobacterium tuberculosis Export disorders for AGMO gene to outside databases
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Publicationsfor AGMO gene (in
PubMed .
Associations of this gene to articles via
1 Entrez Gene ,
2 UniProtKB/Swiss-Prot ,
3 HGNC ,
4 GAD ,
5 PharmGKB ,
6 HMDB ,
7 DrugBank ,
8 UniProtKB/TrEMBL ,
9 Novoseek , and/or
10 fRNAdb )
About This Section PubMed articles for AGMO gene, integrated from 9 sources (see all 11 ): (articles sorted by number of sources associating them with AGMO) Utopia : connect your pdf to the dynamic world of online information
Identification of the gene encoding alkylglycerol mon ooxygenase defines a third class of tetrahydrobiopterin-dependent enzymes. (PubMed id 20643956) 1 , 2 , 3 Watschinger K....Werner E.R. (2010) Human chromosome 7: DNA sequence and biology. (PubMed id 12690205) 1 , 2 Scherer S.W.... Tsui L.-C. (2003) Genome-wide screen for metabolic syndrome susceptibili ty Loci reveals strong lipid gene contribution but no evidence for common geneti c basis for clustering of metabolic syndrome traits. (PubMed id 22399527) 1 Kristiansson K....Salomaa V. (2012) Catalytic residues and a predicted structure of tetrah ydrobiopterin-dependent alkylglycerol mono-oxygenase. (PubMed id 22220568) 1 Watschinger K....Werner E.R. (2012) Genome-wide association study to identify genetic var iants present in Japanese patients harboring intracranial aneurysms. (PubMed id 20613766) 1 Akiyama K....Inoue I. (2010) Evaluating the discriminative power of multi-trait ge netic risk scores for type 2 diabetes in a northern Swedish population. (PubMed id 20571754) 1 Fontaine-Bisson B....Franks P.W. (2010) Variants at DGKB/TMEM195, ADRA2A, GLIS3 and C2CD4B lo ci are associated with reduced glucose-stimulated beta cell function in middle- aged Danish people. (PubMed id 20419449) 1 Boesgaard T.W....Borch-Johnsen K. (2010) New genetic loci implicated in fasting glucose homeos tasis and their impact on type 2 diabetes risk. (PubMed id 20081858) 1 Dupuis J....Zillikens M.C. (2010) The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334) 2 Gerhard D.S....Malek J. (2004) Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039) 2 Ota T.... Sugano S. (2004)
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External Searches for AGMO gene
(in PubMed ,
OMIM , and NCBI Bookshelf ) About This Section
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Genome Databases showing AGMO gene
(According to
Entrez Gene ,
HGNC ,
AceView ,
euGenes ,
Ensembl ,
miRBase ,
ECgene ,
Kegg ,
and/or
H-InvDB )
About This Section
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Other Databases showing AGMO gene
(According to HUGE )
About This Section --
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Specialized Databases showing AGMO gene (According to PharmGKB ,
ATLAS , HORDE , IMGT , LEIDEN , UniProtKB/Swiss-Prot , and/or UniProtKB/TrEMBL ,Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot )About This Section
Name Description
PharmGKB entry for AGMO Pharmacogenomics, SNPs, Pathways
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About This Section Patent Information for AGMO gene: Search GeneIP for patents involving AGMO GeneCards and IP: Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
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Productsfor AGMO gene (Antibodies, recombinant proteins, and assays from EMD Millipore , R&D Systems , OriGene , QIAGEN , GenScript , Cell Signaling Technology , SABiosciences , Novus Biologicals , Sino Biological , Enzo Life Sciences , Abcam , ProSpec , Uscn , Thermo Fisher Scientific , Gene Editing from DNA2.0 and Sirion Biotech , Clones from EMD Millipore , OriGene , GenScript , Sino Biological , DNA2.0 , SwitchGear Genomics , Vector BioLabs , Cell lines from GenScript , LifeMap BioReagents , and Sirion Biotech , PCR Arrays from SABiosciences , Drugs and/or compounds from EMD Millipore , Tocris Bioscience , and/or
Enzo Life Sciences , In Situ Hybridization Assays from Advanced Cell Diagnostics , Animal models from inGenious Targeting Laboratory )About This Section
Browse OriGene Antibodies OriGene shRNA RFP for AGMO OriGene 29mer shRNA kits in GFP-retroviral vector in human , mouse , rat for AGMO OriGene genome-wide validated SYBR primer pairs in human , mouse , rat for AGMO OriGene Protein Over-expression Lysate for AGMO Browse OriGene Fluorogenic Cell Assay Kits OriGene siRNA for AGMO Browse 3'-UTR reporter clones for miRNA target validation OriGene untagged cDNA clones in CMV expression vector in human , mouse , rat for AGMO OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human , mouse , rat for AGMO Browse OriGene GFP tagged cDNA clones in CMV expression vector Browse OriGene MicroRNA Expression Plasmids Browse OriGene basic RS shRNAs Browse OriGene validated miRNA SYBR primer pairs Browse OriGene full length recombinant human proteins expressed in human HEK293 cells OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling OriGene Custom Antibody Services for AGMO OriGene Custom Protein Services for AGMO OriGene Custom Immunoassay Development
QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat AGMO QIAGEN SeqTarget long-range PCR primers in human , mouse , rat for resequencing AGMO QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat AGMO QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human , mouse , rat AGMO QIAGEN QuantiFast Probe-based Assays in human , mouse , rat AGMO QIAGEN QuantiTect SYBR Green Assays in human , mouse , rat AGMO
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Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for AGMO
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Vector BioLabs ready-to-use adenovirus/AAV for human , mouse , rat AGMO
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