Set Analyses:
Advanced Search

Advanced Search

 
Search By
Section (entire)
for


 
or upload a file of gene symbols


Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

AGMAT Gene

protein-coding   GIFtS: 55
GCID: GC01M015898

Agmatine Ureohydrolase (Agmatinase)

  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
Agmatine Ureohydrolase (Agmatinase)1 2
AUH2 3
EC 3.5.3.113 8
Agmatinase, Mitochondrial2
Agmatine Ureohydrolase3
EC 3.5.38

External Ids:    HGNC: 184071   Entrez Gene: 798142   Ensembl: ENSG000001167717   UniProtKB: Q9BSE53   

Export aliases for AGMAT gene to outside databases

Previous GC identifers: GC01M015296 GC01M015078 GC01M015050 GC01M015262 GC01M015261 GC01M015644 GC01M015772 GC01M014418


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

GeneCards Summary for AGMAT Gene: 
AGMAT (agmatine ureohydrolase (agmatinase)) is a protein-coding gene. Diseases associated with AGMAT include mood disorder, and malaria, and among its related super-pathways are Metabolic pathways and Methionine salvage pathway. GO annotations related to this gene include agmatinase activity and metal ion binding. An important paralog of this gene is ARG2.

Gene Wiki entry for AGMAT (Agmatinase) Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000001.10  NC_018912.2  NT_004610.19  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the AGMAT gene promoter:
         Bach1   USF1   AP-2gamma   C/EBPalpha   c-Ets-1   S8   USF-1   c-Myb   SEF-1 (1)   En-1   
         Other transcription factors

Browse SwitchGear Promoter luciferase reporter plasmids
   Search SABiosciences Chromatin IP Primers for AGMAT

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat AGMAT


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 1p36.21   Ensembl cytogenetic band:  1p36.21   HGNC cytogenetic band: 1p36.13

AGMAT Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
AGMAT gene location

GeneLoc information about chromosome 1         GeneLoc Exon Structure

GeneLoc location for GC01M015898:  view genomic region     (about GC identifiers)

Start:
15,898,194 bp from pter      End:
15,911,605 bp from pter
Size:
13,412 bases      Orientation:
minus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: SPEB_HUMAN, Q9BSE5 (See protein sequence)
Recommended Name: Agmatinase, mitochondrial precursor  
Size: 352 amino acids; 37660 Da
Cofactor: Manganese (Potential)
Subcellular location: Mitochondrion
Secondary accessions: Q5TDH1 Q9H5J3

Explore the universe of human proteins at neXtProt for AGMAT: NX_Q9BSE5

Explore proteomics data for AGMAT at MOPED 

Post-translational modifications:

  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_Q9BSE5

  • 4/5 DME Specific Peptides for AGMAT (Q9BSE5) (see all 5)
     RPGARFGP  QALEIIRGC  ANLLFEMLC  RVVQIGIRGSS 

    AGMAT Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    AGMAT Protein Expression
    REFSEQ proteins: NP_079034.3  
    ENSEMBL proteins: 
     ENSP00000364986  
    Reactome Protein details: Q9BSE5
    Human Recombinant Protein Products for AGMAT: 
    Browse Purified and Recombinant Proteins at EMD Millipore
    Browse R&D Systems for human recombinant proteins
    Browse recombinant and purified proteins available from Enzo Life Sciences
    OriGene Purified Protein for AGMAT
    OriGene Protein Over-expression Lysate for AGMAT
    OriGene MassSpec for AGMAT 
    OriGene Custom Protein Services for AGMAT
    GenScript Custom Purified and Recombinant Proteins Services for AGMAT
    Novus Biologicals AGMAT Protein
    Novus Biologicals AGMAT Lysates
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates 
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for AGMAT 

    Gene Ontology (GO): 1 cellular component term (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005739mitochondrion TAS--

    AGMAT for ontologies           About GeneDecksing



    AGMAT Antibody Products: 
    Browse EMD Millipore's Extensive Line of Mono- and Polyclonal Antibodies
    Browse R&D Systems for Antibodies
    OriGene Antibodies for AGMAT
    OriGene Custom Antibody Services for AGMAT
    GenScript Custom Superior Antibodies Services for AGMAT
    Novus Biologicals AGMAT Antibodies
    Abcam antibodies for AGMAT
    Cloud-Clone Corp. Antibodies for AGMAT 
    ThermoFisher Antibody for AGMAT
    LSBio Antibodies in human, mouse, rat for AGMAT 

    Assay Products for AGMAT: 
    Browse Kits and Assays available from EMD Millipore
    OriGene Custom Assay Services for AGMAT
    Browse R&D Systems for biochemical assays
    GenScript Custom Assay Services for AGMAT
    Browse Enzo Life Sciences for kits & assays
    Cloud-Clone Corp. ELISAs for AGMAT 
    Cloud-Clone Corp. CLIAs for AGMAT


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    4 InterPro protein domains:
     IPR006035 Ureohydrolase
     IPR020855 Ureohydrolase_Mn_BS
     IPR023696 Ureohydrolase_domain
     IPR005925 Agmatinase-rel

    Graphical View of Domain Structure for InterPro Entry Q9BSE5

    ProtoNet protein and cluster: Q9BSE5

    2 Blocks protein domains:
    IPB005924 Arginase signature
    IPB006035 Arginase/agmatinase/formiminoglutamase


    UniProtKB/Swiss-Prot: SPEB_HUMAN, Q9BSE5
    Similarity: Belongs to the arginase family. Agmatinase subfamily


    AGMAT for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: SPEB_HUMAN, Q9BSE5
    Catalytic activity: Agmatine + H(2)O = putrescine + urea

         Enzyme Numbers (IUBMB): EC 3.5.3.111 2 EC 3.5.32

         Gene Ontology (GO): 3 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0008783agmatinase activity IEA--
    GO:0016813hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amidines ----
    GO:0046872metal ion binding IEA--
         
    AGMAT for ontologies           About GeneDecksing


    Animal Models:
       inGenious Targeting Laboratory - Custom generated mouse model solutions for AGMAT 
       inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for AGMAT

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for AGMAT 
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for AGMAT 

    miRNA
    Products:
        
    miRTarBase miRNAs that target AGMAT:
    hsa-mir-1 (MIRT001392)

    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat AGMAT
    3 QIAGEN miScript miRNA Assays for microRNAs that regulate AGMAT:
    hsa-miR-922 hsa-miR-33b hsa-miR-33a
    SwitchGear 3'UTR luciferase reporter plasmidAGMAT 3' UTR sequence
    Inhib. RNA
    Products:
        
    Browse for Gene Knock-down Tools from EMD Millipore
    OriGene RNAi products in human, mouse, rat for AGMAT
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat AGMAT

    Gene Editing
    Products:
    DNA2.0 Custom Protein Engineering Service for AGMAT
    Sirion Biotech Customized adenovirus for overexpression of AGMAT

    Clone
    Products:
         
    Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
    OriGene clones in human, mouse for AGMAT (see all 7)
    OriGene ORF clones in mouse, rat for AGMAT
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: AGMAT (NM_024758)
    Sino Biological Human cDNA Clone for AGMAT
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for AGMAT
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat AGMAT
    Sirion Biotech Customized lentivirus for stable overexpression of AGMAT 
                         Customized lentivirus expression plasmids for stable overexpression of AGMAT 

    Cell Line
    Products:
         
    GenScript Custom overexpressing Cell Line Services for AGMAT
    Search LifeMap BioReagents cell lines for AGMAT
    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for AGMAT


    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section

    SuperPaths for AGMAT About                                                                                                See pathways by source

    SuperPathContained pathways About
    1Metabolism
    Metabolism0.40
    Metabolic pathways0.40
    2Methionine salvage pathway
    Metabolism of polyamines0.40
    3Arginine and proline metabolism
    Arginine and proline metabolism0.35
    4putrescine biosynthesis III
    Agmatine biosynthesis0.33
    5Metabolism of amino acids and derivatives
    Metabolism of amino acids and derivatives

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways



    4        Reactome Pathways for AGMAT
        Agmatine biosynthesis
    Metabolism of polyamines
    Metabolism
    Metabolism of amino acids and derivatives


    2         Kegg Pathways  (Kegg details for AGMAT):
        Arginine and proline metabolism
    Metabolic pathways

    UniProtKB/Swiss-Prot: SPEB_HUMAN, Q9BSE5
    Pathway: Amine and polyamine biosynthesis; putrescine biosynthesis via agmatine pathway; putrescine from agmatine:
    step 1/1


    AGMAT for pathways           About GeneDecksing

    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for AGMAT

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    5/29 Interacting proteins for AGMAT (ENSP000003649864) via UniProtKB, MINT, STRING, and/or I2D (see all 29)

    InteractantInteraction Details
    GeneCardExternal ID(s)
    ADCENSP000002945174STRING: ENSP00000294517
    AOC1ENSP000003541934STRING: ENSP00000354193
    DEPDC1ENSP000004122924STRING: ENSP00000412292
    ODC1ENSP000002341114STRING: ENSP00000234111
    SAT1ENSP000003685724STRING: ENSP00000368572
    About this table

    Gene Ontology (GO): 5/6 biological process terms (GO ID links to tree view) (see all 6):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006595polyamine metabolic process TAS--
    GO:0008295spermidine biosynthetic process IEA--
    GO:0033388putrescine biosynthetic process from arginine IEA--
    GO:0034641cellular nitrogen compound metabolic process TAS--
    GO:0044281small molecule metabolic process TAS--

    AGMAT for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section

    AGMAT for compounds           About GeneDecksing

    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for AGMAT (SPEB)

    10 HMDB Compounds for AGMAT    About this table
    CompoundSynonyms CAS #PubMed Ids
    Agmatine(4-Aminobutyl)guanidine (see all 11)306-60-5--
    Guanidine(4-Aminobutyl) guanidine (see all 8)50-01-1--
    Manganesemanganese 7439-96-5--
    N1-AcetylspermineN'-Acetylspermine (see all 6)25593-72-0--
    NorspermidineN-(3-aminopropyl)-1,3-Propanediamine (see all 28)56-18-8--
    Putrescine1,4-Butanediamine (see all 8)110-60-1--
    Spermidine1,5,10-Triazadecane (see all 15)124-20-9--
    Spermine1,5,10,14-Tetraazatetradecane (see all 18)71-44-3--
    UreaCarbonyl diamine (see all 90)57-13-6--
    WaterDihydrogen oxide (see all 2)7732-18-5--

    10 Novoseek inferred chemical compound relationships for AGMAT gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    agmatine 93.8 14 9494113 (1), 14648699 (1), 15522599 (1), 11914032 (1) (see all 11)
    hexamethylenediamine 83.7 1 16511187 (1)
    putrescine 79.3 7 9494113 (1), 9851555 (1), 14648699 (1), 15522599 (1) (see all 7)
    arginine 65.6 13 15090903 (3), 9494113 (1), 16128822 (1), 11914032 (1) (see all 6)
    ornithine 60.3 2 19286931 (1), 11804860 (1)
    spermidine 45 1 15355972 (1)
    spermine 43.3 1 15355972 (1)
    amine 40 1 9494113 (1)
    manganese 30.6 1 15355972 (1)
    morphine 19.5 1 17025265 (1)

    Search CenterWatch for drugs/clinical trials and news about AGMAT / SPEB

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for AGMAT gene: 
    NM_024758.4  

    Unigene Cluster for AGMAT:

    Agmatine ureohydrolase (agmatinase)
    Hs.461532  [show with all ESTs]
    Unigene Representative Sequence: NM_024758
    1 Ensembl transcript including schematic representation, and UCSC links where relevant:
    ENST00000375826(uc001awv.2)
    miRNA
    Products:
         
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat AGMAT
    3 QIAGEN miScript miRNA Assays for microRNAs that regulate AGMAT:
    hsa-miR-922 hsa-miR-33b hsa-miR-33a
    SwitchGear 3'UTR luciferase reporter plasmidAGMAT 3' UTR sequence
    Inhib. RNA
    Products:
         
    Browse for Gene Knock-down Tools from EMD Millipore
    OriGene RNAi products in human, mouse, rat for AGMAT
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat AGMAT
    Clone
    Products:
         
    OriGene clones in human, mouse for AGMAT (see all 7)
    OriGene ORF clones in mouse, rat for AGMAT
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: AGMAT (NM_024758)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for AGMAT
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat AGMAT
    Sirion Biotech Customized lentivirus for stable overexpression of AGMAT 
                         Customized lentivirus expression plasmids for stable overexpression of AGMAT 
    Primer
    Products:
        
    OriGene qPCR primer pairs and template standards for AGMAT
    OriGene qSTAR qPCR primer pairs in human, mouse for AGMAT
    SABiosciences RT2 qPCR Primer Assay in human, mouse, rat AGMAT
      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat AGMAT
      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat AGMAT

    Additional mRNA sequence: 

    AK130034.1 AK225366.1 AY057097.1 BC005090.1 

    8 DOTS entries:

    DT.308843  DT.95164407  DT.91828828  DT.100745527  DT.97839308  DT.100751882  DT.86854932  DT.95164406 

    24/84 AceView cDNA sequences (see all 84):

    AI261350 AW206473 BM853724 AI653589 CA312785 BF476183 BM788254 AW299579 
    BU675534 AI439108 AW614215 AA934764 AI186209 BE465248 AI492488 F32232 
    AW611892 AW611556 AW058507 AI521141 AW237392 BF806682 AI863485 BG403443 

    GeneLoc Exon Structure

    2 Alternative Splicing Database (ASD) splice patterns (SP) for AGMAT    About this scheme

    ExUns: 1a · 1b ^ 2 ^ 3 ^ 4 ^ 5 ^ 6a · 6b ^ 7
    SP1:                                                      
    SP2:                                -                     


    ECgene alternative splicing isoforms for AGMAT

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    AGMAT expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: --
    AGMAT Expression
    About this image


    See AGMAT Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for AGMAT

    SOURCE GeneReport for Unigene cluster: Hs.461532

    UniProtKB/Swiss-Prot: SPEB_HUMAN, Q9BSE5
    Tissue specificity: Highly expressed in liver and kidney. Also found in skeletal muscle, fetal liver, brain,
    testis, skin and the gastrointestinal tract

        SABiosciences Expression via Pathway-Focused PCR Array including AGMAT: 
              Amino Acid Metabolism I in human mouse rat

    Primer
    Products:
    OriGene qPCR primer pairs and template standards for AGMAT
    OriGene qSTAR qPCR primer pairs in human, mouse for AGMAT
    SABiosciences RT2 qPCR Primer Assay in human, mouse, rat AGMAT
    QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat AGMAT
    QIAGEN QuantiFast Probe-based Assays in human, mouse, rat AGMAT
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for AGMAT

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of animals and fungi.

    Orthologs for AGMAT gene from 5/17 species (see all 17)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Agmat1 , 5 agmatine ureohydrolase (agmatinase)1, 5 82.58(n)1
    84.09(a)1
      4 (74.75 cM)5
    759861  NM_001081408.11  NP_001074877.11 
     1417466725 
    chicken
    (Gallus gallus)
    Aves AGMAT1 agmatine ureohydrolase (agmatinase) 73.77(n)
    80.88(a)
      373942  NM_204143.2  NP_989474.1 
    zebrafish
    (Danio rerio)
    Actinopterygii agmat1 agmatine ureohydrolase (agmatinase) 65.51(n)
    70.57(a)
      556522  NM_001077551.1  NP_001071019.1 
    worm
    (Caenorhabditis elegans)
    Secernentea T21F4.16
    Protein T21F4.1, isoform a
    11(a)
    1 ↔ 1
    X(5630356-5638098)
    baker's yeast
    (Saccharomyces cerevisiae)
    Saccharomycetes CAR16
    Arginase, responsible for arginine degradation, ex...
    13(a)
    1 → many
    XVI(339944-340945)


    ENSEMBL Gene Tree for AGMAT (if available)
    TreeFam Gene Tree for AGMAT (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for AGMAT gene
    ARG22  ARG12  

    AGMAT for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/369 SNPs in AGMAT are shown (see all 369)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 1 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs344141681,2
    F--15898831(+) TGAGCC/TACTGG 1 -- ut311Minor allele frequency- T:0.06WA 118
    rs1918934171,2
    --15898841(+) GGTCCA/GGCCTG 1 -- ut310--------
    rs595134621,2
    C,F--15898940(+) ACCTCC/TACCTC 1 -- ut312Minor allele frequency- T:0.50NA CSA 4
    rs1124860691,2
    C,F--15898941(+) CCTCCG/ACCTCC 1 -- ut311Minor allele frequency- A:0.50WA 2
    rs1888518111,2
    C--15899003(+) GCACGC/TGCCAC 1 -- ut310--------
    rs1385083101,2
    --15899015(+) ACGCCC/TAGCTA 1 -- ut310--------
    rs1450573181,2
    C--15899025(+) AACTT-/CTGTAT 1 -- ut310--------
    rs1928900931,2
    --15899052(+) TTTTCA/CCCATG 1 -- ut310--------
    rs1857339281,2
    --15899113(+) GCCCCC/GCAAAG 1 -- ut310--------
    rs1496376411,2
    --15899141(+) TGAGCC/TACCGT 1 -- ut310--------

    HapMap Linkage Disequilibrium report for AGMAT (15898194 - 15911605 bp)

    Structural Variations
          Database of Genomic Variants (DGV) variations for AGMAT: --
    SABiosciences Cancer Mutation PCR Assays
    SeqTarget long-range PCR primers for resequencing AGMAT
    DNA2.0 Custom Variant and Variant Library Synthesis for AGMAT

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    7 diseases for AGMAT:    About MalaCards
    mood disorder    malaria    renal cell carcinoma    hepatitis b
    asthma    hepatitis    gastric cancer


    AGMAT for disorders           About GeneDecksing

    2 Novoseek inferred disease relationships for AGMAT gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    carcinoma renal cell 23.3 1 14648699 (1)
    tumors 0 2 14648699 (2)

    Genetic Association Database (GAD): AGMAT
    Human Genome Epidemiology (HuGE) Navigator: AGMAT (3 documents)

    Export disorders for AGMAT gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for AGMAT gene, integrated from 9 sources (see all 38):
    (articles sorted by number of sources associating them with AGMAT)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Cloning of human agmatinase. An alternate path for polyamine synthesis induced in liver by hepatitis B virus. (PubMed id 11804860)1, 2, 3, 9 Mistry S.K.... Morris S.M. Jr. (2002)
    2. Human agmatinase is diminished in the clear cell type of renal cell carcinoma. (PubMed id 14648699)1, 3, 9 Dallmann K....Walther R. (2004)
    3. Cloning and characterization of human agmatinase. (PubMed id 11914032)1, 3, 9 Iyer R.K....Cederbaum S.D. (2002)
    4. Novel association strategy with copy number variation for identifying new risk Loci of human diseases. (PubMed id 20808825)1, 4 Chen X....Kong X. (2010)
    5. Genetic variants in nuclear-encoded mitochondrial gen es influence AIDS progression. (PubMed id 20877624)1, 4 Hendrickson S.L....O'Brien S.J. (2010)
    6. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PubMed id 20379614)1, 4 Rose J.E....Uhl G.R. (2010)
    7. The DNA sequence and biological annotation of human chromosome 1. (PubMed id 16710414)1, 2 Gregory S.G.... Bentley D.R. (2006)
    8. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (2004)
    9. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    10. Expression, crystallization and preliminary X-ray crystallographic analysis of human agmatinase. (PubMed id 16511187)1, 9 Kim K.H....Suh S.W. (2005)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 79814 HGNC: 18407 AceView: AGMAT Ensembl:ENSG00000116771 euGenes: HUgn79814
    ECgene: AGMAT Kegg: 79814 H-InvDB: AGMAT

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for AGMAT Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for AGMAT gene:
    Search GeneIP for patents involving AGMAT

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0 and Sirion Biotech, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Sirion Biotech, Cell lines from GenScript, and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
    About This Section

     
     EMD Millipore Custom Antibody & Bulk Services
     EMD Millipore Preclinical / Clinical Development Services
     EMD Millipore Immunoassay Services
     EMD Millipore Target Screening & Profiling Services

      
     Browse Antibodies   Browse Cell Culture Products  
     Browse ELISAs   Browse Flow Cytometry Kits  
     Browse Primer Pairs   Browse Kinase Activity Assays/Reagents  
     Browse ELISpot Kits/Development Modules   Browse TFB/Immunoprecipitation Assays  
     Browse Apoptosis Detection Kits/Reagents   Browse Ubiquitin Proteasome Pathway (UPP) Assay Kits/Reagents  
     Browse DNA Damage/Repair Kits/Reagents   Browse Multiplex/Array Assay Kits/Reagents  
     Browse Cell Selection/Detection Kits/Reagents   Browse Secondary Antibodies/Controls/Staining Reagents  
     Browse Protease Activity Assays and Reagents   Browse Recombinant/Natural Proteins  
     Browse Stem Cell Products   Browse Tocris Biochemicals & Compounds  
     Browse cDNA Clones   Browse Proteome Profiler Antibody Arrays  
     OriGene Antibodies for AGMAT   OriGene RNAi products in human, mouse, rat for AGMAT  
     OriGene qPCR primer pairs and template standards for AGMAT   OriGene Protein Over-expression Lysate for AGMAT  
     OriGene MassSpec something-or-other for AGMAT   OriGene clones in human, mouse for AGMAT  
     OriGene qSTAR qPCR primer pairs in human, mouse for AGMAT   OriGene Purified Protein for AGMAT  
     OriGene ORF clones in mouse, rat for AGMAT   OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling  
     OriGene Custom Antibody Services for AGMAT   OriGene Custom Protein Services for AGMAT  

     
     
     QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat AGMAT
     QIAGEN SeqTarget long-range PCR primers for resequencing AGMAT
     QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat AGMAT
     QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat AGMAT
     QIAGEN QuantiFast Probe-based Assays in human, mouse, rat AGMAT
     QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat AGMAT
     GenScript Custom Purified and Recombinant Proteins Services for AGMAT GenScript cDNA clones with any tag delivered in your preferred vector for AGMAT
     GenScript Custom Assay Services for AGMAT GenScript Custom Superior Antibodies Services for AGMAT
     GenScript Custom overexpressing Cell Line Services for AGMAT CloneReady with Over 120,000 Genes
     Gene Synthesis: Any Gene in Any Vector Vector-based siRNA and miRNA, Ready for Transfection
     Gene Mutant Library, Variants up to 10^11 Plasmid Preparation
     Custom Peptide Services
     Search for Antibodies & Assays

     Regulatory tfbs in AGMAT promoter
     Search Chromatin IP Primers for AGMAT
     RT2 qPCR Primer Assay in human, mouse, rat AGMAT
     Search GNC Networks for AGMAT
     SABiosciences PCR Arrays including human, mouse, rat AGMAT
     Search Tocris compounds for AGMAT (SPEB)
     Browse Sino Biological Proteins and Antibodies
     Browse Sino Biological Cell Lysates
     cDNA Clones for AGMAT
     4000+ Proteins
     Search Sino Biological for antibodies, proteins & pathways
     Protein Production Services
     Transfection Reagents
     Protein A/G/L resins
     Isotyping reagents
     Search www.enzolifesciences.com for proteins, assays, substrates, inhibitors & antibodies
     Novus Tissue Slides
     AGMAT antibodies
     AGMAT proteins
     AGMAT lysates
     Antibodies for AGMAT
     See all of Abcam's Antibodies, Kits and Proteins for AGMAT
     Custom Antibody / Protein Production Service
     Bulk Purchasing
     Advantages of Rabbit Monoclonal antibodies
     Abcam protocols and scientific support
     Browse ProSpec Recombinant Proteins




     Proteins for AGMAT
     Antibodies for AGMAT
     ELISAs for AGMAT
     CLIAs for AGMAT
     Search LifeMap BioReagents cell lines for AGMAT
     Gene Synthesis
     Protein Engineering
     Variant Library Synthesis
     Codon Optimization
     Protein Production and Purification
     Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for AGMAT
     SwitchGear 3'UTR luciferase reporter plasmids for AGMAT
     Browse SwitchGear Promoter luciferase reporter plasmids for AGMAT
     ThermoFisher Antibody for AGMAT
     Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat AGMAT
     inGenious Targeting Laboratory - Custom generated mouse model solutions for AGMAT
     inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for AGMAT
    Customized:
     lentivirus for stable overexpression of AGMAT
     lentivirus expression plasmids for stable overexpression of AGMAT
     adenovirus for overexpression of AGMAT
     LSBio Antibodies in human, mouse, rat for AGMAT
    Customized transgenic rodents for:
     Humanization
     Biomarker expression
     Off-target effect monitoring
     Translational medicine
     Tissue-specific gene expresssion
     Time-controlled gene expresssion
           
    GeneCards Homepage - Last full update: 23 Oct 2013 - Incrementals: 4 Nov 2013 , 7 Nov 2013 , 23 Jan 2014

    View Random Gene

    Category
    (GIFtS: 73)
    transforming growth factor, beta 1
    GIFtS Group
    The GeneCards human gene database gene index: 1 3 5 6 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z 


    Developed at the Crown Human Genome Center, Department of Molecular Genetics, the Weizmann Institute of Science

    Hot genes      Disease genes      AGMAT gene at Home site.
    hostname: 356977-web1.xennexinc.com index build: 106 solr: 1.4