Free for academic non-profit institutions. Other users need a Commercial license

Aliases for AGMAT Gene

Aliases for AGMAT Gene

  • Agmatine Ureohydrolase (Agmatinase) 2 3
  • EC 3.5.3.11 4 63
  • AUH 3 4
  • Agmatine Ureohydrolase 4
  • EC 3.5.3 63

External Ids for AGMAT Gene

Previous GeneCards Identifiers for AGMAT Gene

  • GC01M015296
  • GC01M015078
  • GC01M015050
  • GC01M015262
  • GC01M015261
  • GC01M015644
  • GC01M015772
  • GC01M015898
  • GC01M014418

Summaries for AGMAT Gene

GeneCards Summary for AGMAT Gene

AGMAT (Agmatine Ureohydrolase (Agmatinase)) is a Protein Coding gene. Among its related pathways are Metabolism and Arginine and proline metabolism. GO annotations related to this gene include agmatinase activity. An important paralog of this gene is ARG1.

Gene Wiki entry for AGMAT Gene

No data available for Entrez Gene Summary , UniProtKB/Swiss-Prot , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for AGMAT Gene

Genomics for AGMAT Gene

Regulatory Elements for AGMAT Gene

Genomic Location for AGMAT Gene

Chromosome:
1
Start:
15,571,699 bp from pter
End:
15,585,110 bp from pter
Size:
13,412 bases
Orientation:
Minus strand

Genomic View for AGMAT Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
GeneLoc Logo Gene Density

RefSeq DNA sequence for AGMAT Gene

Proteins for AGMAT Gene

  • Protein details for AGMAT Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9BSE5-SPEB_HUMAN
    Recommended name:
    Agmatinase, mitochondrial
    Protein Accession:
    Q9BSE5
    Secondary Accessions:
    • Q5TDH1
    • Q9H5J3

    Protein attributes for AGMAT Gene

    Size:
    352 amino acids
    Molecular mass:
    37660 Da
    Cofactor:
    Name=Mn(2+); Xref=ChEBI:CHEBI:29035;
    Quaternary structure:
    No Data Available

neXtProt entry for AGMAT Gene

Proteomics data for AGMAT Gene at MOPED

Selected DME Specific Peptides for AGMAT Gene

Post-translational modifications for AGMAT Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for AGMAT Gene

ENSEMBL proteins:
REFSEQ proteins:

Antibody Products

Domains & Families for AGMAT Gene

Suggested Antigen Peptide Sequences for AGMAT Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q9BSE5

UniProtKB/Swiss-Prot:

SPEB_HUMAN :
  • Belongs to the arginase family. Agmatinase subfamily.
Family:
  • Belongs to the arginase family. Agmatinase subfamily.
genes like me logo Genes that share domains with AGMAT: view

No data available for Gene Families for AGMAT Gene

Function for AGMAT Gene

Molecular function for AGMAT Gene

UniProtKB/Swiss-Prot CatalyticActivity:
Agmatine + H(2)O = putrescine + urea.

Enzyme Numbers (IUBMB) for AGMAT Gene

Gene Ontology (GO) - Molecular Function for AGMAT Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0008783 agmatinase activity IEA --
GO:0016813 hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amidines --
GO:0046872 metal ion binding IEA --
genes like me logo Genes that share ontologies with AGMAT: view

Phenotypes for AGMAT Gene

genes like me logo Genes that share phenotypes with AGMAT: view

Animal Model Products

miRNA for AGMAT Gene

miRTarBase miRNAs that target AGMAT

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for AGMAT

In Situ Assay Products

Flow Cytometry Products

No data available for Animal Models , Transcription Factor Targets and HOMER Transcription for AGMAT Gene

Localization for AGMAT Gene

Subcellular locations from UniProtKB/Swiss-Prot for AGMAT Gene

Mitochondrion.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for AGMAT Gene COMPARTMENTS Subcellular localization image for AGMAT gene
Compartment Confidence
extracellular 5
mitochondrion 5

Gene Ontology (GO) - Cellular Components for AGMAT Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005739 mitochondrion TAS --
GO:0070062 extracellular exosome IDA 23376485
genes like me logo Genes that share ontologies with AGMAT: view

Pathways & Interactions for AGMAT Gene

genes like me logo Genes that share pathways with AGMAT: view

PCR Array Products

  • Pathway & Disease-focused RT² Profiler PCR Arrays

UniProtKB/Swiss-Prot Q9BSE5-SPEB_HUMAN

  • Pathway: Amine and polyamine biosynthesis; putrescine biosynthesis via agmatine pathway; putrescine from agmatine: step 1/1

Interacting Proteins for AGMAT Gene

Gene Ontology (GO) - Biological Process for AGMAT Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006595 polyamine metabolic process TAS --
GO:0008295 spermidine biosynthetic process IEA --
GO:0033388 putrescine biosynthetic process from arginine IEA --
GO:0034641 cellular nitrogen compound metabolic process TAS --
GO:0044281 small molecule metabolic process TAS --
genes like me logo Genes that share ontologies with AGMAT: view

No data available for SIGNOR curated interactions for AGMAT Gene

Drugs & Compounds for AGMAT Gene

(10) Drugs for AGMAT Gene - From: NovoSeek and HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
spermine Approved Nutra Channel blocker 0
Guanidine Approved Pharma 0
Morphine Approved, Investigational Pharma Partial agonist, Agonist 805
Ornithine Approved Nutra Full agonist, Agonist 31
agmatine Experimental, Investigational Pharma Activator 0

(5) Additional Compounds for AGMAT Gene - From: HMDB and NovoSeek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
N1-acetylspermine
  • N'-Acetylspermine
  • N'-Monoacetylspermine
  • N(1)-Acetylspermine
  • N-(3-((4-((3-Aminopropyl)amino)butyl)amino)propyl)-Acetamide
  • N-Acetylspermine
25593-72-0
Norspermidine
  • -1,3-propanediamine
  • 1,7-Diamino-4-azaheptane
  • 3, 3'-Diaminodipropylamine
  • 3, {3'-Iminobis[propylamine]}
  • 3,3'-Diamino-Dipropylamine
56-18-8
Water
  • Dihydrogen oxide
  • Steam
7732-18-5
Amine
hexamethylenediamine
genes like me logo Genes that share compounds with AGMAT: view

Transcripts for AGMAT Gene

mRNA/cDNA for AGMAT Gene

(1) REFSEQ mRNAs :
(4) Additional mRNA sequences :
(84) Selected AceView cDNA sequences:
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for AGMAT Gene

Agmatine ureohydrolase (agmatinase):
Representative Sequences:

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for AGMAT

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for AGMAT Gene

ExUns: 1a · 1b ^ 2 ^ 3 ^ 4 ^ 5 ^ 6a · 6b ^ 7
SP1:
SP2: -

Relevant External Links for AGMAT Gene

GeneLoc Exon Structure for
AGMAT
ECgene alternative splicing isoforms for
AGMAT

Expression for AGMAT Gene

mRNA expression in normal human tissues for AGMAT Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for AGMAT Gene

This gene is overexpressed in Kidney - Cortex (x24.3) and Liver (x12.3).

Protein differential expression in normal tissues from HIPED for AGMAT Gene

This gene is overexpressed in Kidney (49.7).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for AGMAT Gene



SOURCE GeneReport for Unigene cluster for AGMAT Gene Hs.461532

mRNA Expression by UniProt/SwissProt for AGMAT Gene

Q9BSE5-SPEB_HUMAN
Tissue specificity: Highly expressed in liver and kidney. Also found in skeletal muscle, fetal liver, brain, testis, skin and the gastrointestinal tract. Within brain, expression is higher in the cerebral cortex with lower levels in the medulla and spinal cord.
genes like me logo Genes that share expression patterns with AGMAT: view

Primer Products

In Situ Assay Products

No data available for Protein tissue co-expression partners for AGMAT Gene

Orthologs for AGMAT Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for AGMAT Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia AGMAT 35
  • 87.65 (n)
  • 87.18 (a)
AGMAT 36
  • 82 (a)
OneToOne
dog
(Canis familiaris)
Mammalia AGMAT 35
  • 87.88 (n)
  • 87.22 (a)
AGMAT 36
  • 87 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Agmat 35
  • 82.48 (n)
  • 84.09 (a)
Agmat 16
Agmat 36
  • 78 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia AGMAT 35
  • 99.15 (n)
  • 99.15 (a)
AGMAT 36
  • 99 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Agmat 35
  • 81.53 (n)
  • 81.25 (a)
oppossum
(Monodelphis domestica)
Mammalia AGMAT 36
  • 70 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia AGMAT 36
  • 87 (a)
OneToOne
chicken
(Gallus gallus)
Aves AGMAT 35
  • 73.77 (n)
  • 80.88 (a)
AGMAT 36
  • 74 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia agmat 35
  • 70.99 (n)
  • 78.48 (a)
zebrafish
(Danio rerio)
Actinopterygii agmat 35
  • 65.51 (n)
  • 70.57 (a)
agmat 36
  • 61 (a)
OneToOne
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.6064 35
worm
(Caenorhabditis elegans)
Secernentea T21F4.1 36
  • 13 (a)
OneToOne
K. lactis yeast
(Kluyveromyces lactis)
Saccharomycetes KLLA0F04235g 35
  • 44.98 (n)
  • 37.86 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes CAR1 36
  • 18 (a)
OneToMany
thale cress
(Arabidopsis thaliana)
eudicotyledons AT4G08900 35
  • 45.93 (n)
  • 37.79 (a)
rice
(Oryza sativa)
Liliopsida Os04g0106300 35
  • 46.16 (n)
  • 36.6 (a)
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.395 35
bread mold
(Neurospora crassa)
Ascomycetes NCU01348 35
  • 47.96 (n)
  • 38.78 (a)
fission yeast
(Schizosaccharomyces pombe)
Schizosaccharomycetes SPAC11D3.09 35
  • 46.94 (n)
  • 38.44 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 65 (a)
OneToMany
-- 36
  • 58 (a)
OneToMany
Species with no ortholog for AGMAT:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for AGMAT Gene

ENSEMBL:
Gene Tree for AGMAT (if available)
TreeFam:
Gene Tree for AGMAT (if available)

Paralogs for AGMAT Gene

Paralogs for AGMAT Gene

genes like me logo Genes that share paralogs with AGMAT: view

Variants for AGMAT Gene

Sequence variations from dbSNP and Humsavar for AGMAT Gene

SNP ID Clin Chr 01 pos Sequence Context AA Info Type MAF
rs2861385 -- 15,581,089(+) caggc(A/G)cagtg intron-variant
rs3210999 -- 15,572,357(+) ttttt(C/T)ttttt utr-variant-3-prime
rs3211000 -- 15,572,369(+) ttttt(C/T)ttttt utr-variant-3-prime
rs3737705 -- 15,584,854(+) GGCGC(A/G)TCGGA reference, synonymous-codon
rs6429752 -- 15,573,976(+) AAGGA(A/G)AACCT intron-variant

Variation tolerance for AGMAT Gene

Residual Variation Intolerance Score: 56.5% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 7.38; 81.72% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for AGMAT Gene

HapMap Linkage Disequilibrium report
AGMAT

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Structural Variations from Database of Genomic Variants (DGV) for AGMAT Gene

Disorders for AGMAT Gene

Relevant External Links for AGMAT

Genetic Association Database (GAD)
AGMAT
Human Genome Epidemiology (HuGE) Navigator
AGMAT
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
AGMAT
genes like me logo Genes that share disorders with AGMAT: view

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for AGMAT Gene

Publications for AGMAT Gene

  1. Human agmatinase is diminished in the clear cell type of renal cell carcinoma. (PMID: 14648699) Dallmann K. … Walther R. (Int. J. Cancer 2004) 2 23 67
  2. Cloning of human agmatinase. An alternate path for polyamine synthesis induced in liver by hepatitis B virus. (PMID: 11804860) Mistry S.K. … Morris S.M. Jr. (Am. J. Physiol. 2002) 2 23 67
  3. Cloning and characterization of human agmatinase. (PMID: 11914032) Iyer R.K. … Cederbaum S.D. (Mol. Genet. Metab. 2002) 2 23 67
  4. [Differentially expressed proteins in the precancerous stage of rat hepatocarcinogenesis induced by diethylnitrosamine]. (PMID: 19785954) Liang H.J. … Liu Y.K. (Zhonghua Gan Zang Bing Za Zhi 2009) 23 67
  5. Functionally important role for arginase 1 in the airway hyperresponsiveness of asthma. (PMID: 19286931) North M.L. … Scott J.A. (Am. J. Physiol. Lung Cell Mol. Physiol. 2009) 23 67

Products for AGMAT Gene

Sources for AGMAT Gene

Back to Top

Content