Aliases for AGL Gene
- Amylo-Alpha-1, 6-Glucosidase, 4-Alpha-Glucanotransferase 2 3 5
- Amylo-1, 6-Glucosidase, 4-Alpha-Glucanotransferase 2 3
- Glycogen Debranching Enzyme 2 3
- Glycogen Debrancher 3 4
- GDE 3 4
- Amylo-Alpha-1, 6-Glucosidase, 4-Alpha-Glucanotransferaseprovided 3
- Glycogen Storage Disease Type III 2
- Glycogen Debranching Protein 3
External Ids for AGL Gene
Previous GeneCards Identifiers for AGL Gene
This gene encodes the glycogen debrancher enzyme which is involved in glycogen degradation. This enzyme has two independent catalytic activities which occur at different sites on the protein: a 4-alpha-glucotransferase activity and a amylo-1,6-glucosidase activity. Mutations in this gene are associated with glycogen storage disease although a wide range of enzymatic and clinical variability occurs which may be due to tissue-specific alternative splicing. Alternatively spliced transcripts encoding different isoforms have been described. [provided by RefSeq, Jul 2008]
GeneCards Summary for AGL Gene
AGL (Amylo-Alpha-1, 6-Glucosidase, 4-Alpha-Glucanotransferase) is a Protein Coding gene. Diseases associated with AGL include Glycogen Storage Disease Iiia and Glycogen Storage Disease. Among its related pathways are Metabolism and Immune System. GO annotations related to this gene include carbohydrate binding and polysaccharide binding. An important paralog of this gene is ENSG00000283495.
UniProtKB/Swiss-Prot for AGL Gene
Multifunctional enzyme acting as 1,4-alpha-D-glucan:1,4-alpha-D-glucan 4-alpha-D-glycosyltransferase and amylo-1,6-glucosidase in glycogen degradation.
Glycosylases are a group of enzymes that includes glucosidases, mannosidases and heparanases. There are two glucosidase subtypes, both found in the gut. They hydrolyze terminal (1,4)alpha-glucosidic linkages and (1,6)beta-glucosidic linkages, liberating alpha-glucose and beta-glucose.