Aliases for AGK Gene
External Ids for AGK Gene
Previous HGNC Symbols for AGK Gene
Previous GeneCards Identifiers for AGK Gene
The protein encoded by this gene is a mitochondrial membrane protein involved in lipid and glycerolipid metabolism. The encoded protein is a lipid kinase that catalyzes the formation of phosphatidic and lysophosphatidic acids. Defects in this gene have been associated with mitochondrial DNA depletion syndrome 10. [provided by RefSeq, Feb 2012]
GeneCards Summary for AGK Gene
AGK (Acylglycerol Kinase) is a Protein Coding gene. Diseases associated with AGK include non-syndromic congenital cataract and sengers syndrome. Among its related pathways are Metabolism and Regulation of lipid metabolism by Peroxisome proliferator-activated receptor alpha (PPARalpha). GO annotations related to this gene include NAD+ kinase activity and lipid kinase activity. An important paralog of this gene is SPHK1.
UniProtKB/Swiss-Prot for AGK Gene
Lipid kinase that can phosphorylate both monoacylglycerol and diacylglycerol to form lysophosphatidic acid (LPA) and phosphatidic acid (PA), respectively. Does not phosphorylate sphingosine. Overexpression increases the formation and secretion of LPA, resulting in transactivation of EGFR and activation of the downstream MAPK signaling pathway, leading to increased cell growth.