Free for academic non-profit institutions. Other users need a Commercial license

Aliases for AGK Gene

Aliases for AGK Gene

  • Acylglycerol Kinase 2 3
  • Multiple Substrate Lipid Kinase 2 3 4
  • MULK 3 4 6
  • Multi-Substrate Lipid Kinase 3 4
  • CTRCT38 3 6
  • MTDPS10 3 6
  • HsMuLK 3 4
  • CATC5 3 6
  • HAGK 3 4
  • Acylglycerol Kinase, Mitochondrial 3
  • EC 2.7.1.107 4
  • EC 2.7.1.94 4

External Ids for AGK Gene

Previous HGNC Symbols for AGK Gene

  • MULK

Previous GeneCards Identifiers for AGK Gene

  • GC07P140899
  • GC07P141250
  • GC07P135547

Summaries for AGK Gene

Entrez Gene Summary for AGK Gene

  • The protein encoded by this gene is a mitochondrial membrane protein involved in lipid and glycerolipid metabolism. The encoded protein is a lipid kinase that catalyzes the formation of phosphatidic and lysophosphatidic acids. Defects in this gene have been associated with mitochondrial DNA depletion syndrome 10. [provided by RefSeq, Feb 2012]

GeneCards Summary for AGK Gene

AGK (Acylglycerol Kinase) is a Protein Coding gene. Diseases associated with AGK include sengers syndrome and cataract 38, autosomal recessive. Among its related pathways are Metabolism and Glycerolipid metabolism. GO annotations related to this gene include NAD+ kinase activity and ceramide kinase activity. An important paralog of this gene is SPHK2.

UniProtKB/Swiss-Prot for AGK Gene

  • Lipid kinase that can phosphorylate both monoacylglycerol and diacylglycerol to form lysophosphatidic acid (LPA) and phosphatidic acid (PA), respectively. Does not phosphorylate sphingosine. Overexpression increases the formation and secretion of LPA, resulting in transactivation of EGFR and activation of the downstream MAPK signaling pathway, leading to increased cell growth.

Gene Wiki entry for AGK Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for AGK Gene

Genomics for AGK Gene

Regulatory Elements for AGK Gene

Genomic Location for AGK Gene

Start:
141,551,189 bp from pter
End:
141,655,244 bp from pter
Size:
104,056 bases
Orientation:
Plus strand

Genomic View for AGK Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for AGK Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for AGK Gene

Proteins for AGK Gene

  • Protein details for AGK Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q53H12-AGK_HUMAN
    Recommended name:
    Acylglycerol kinase, mitochondrial
    Protein Accession:
    Q53H12
    Secondary Accessions:
    • Q75KN1
    • Q96GC3
    • Q9NP48

    Protein attributes for AGK Gene

    Size:
    422 amino acids
    Molecular mass:
    47137 Da
    Cofactor:
    Name=Mg(2+); Xref=ChEBI:CHEBI:18420;
    Quaternary structure:
    No Data Available
    Miscellaneous:
    • Overexpressed in prostate cancer, suggesting that it may play a role in initiation and progression of prostate cancer, processes in which LPA plays key roles

    Alternative splice isoforms for AGK Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for AGK Gene

Proteomics data for AGK Gene at MOPED

Post-translational modifications for AGK Gene

  • Ubiquitination at Lys223
  • Modification sites at PhosphoSitePlus

Other Protein References for AGK Gene

No data available for DME Specific Peptides for AGK Gene

Domains for AGK Gene

Protein Domains for AGK Gene

Suggested Antigen Peptide Sequences for AGK Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q53H12

UniProtKB/Swiss-Prot:

AGK_HUMAN :
  • Q53H12
Domain:
  • Contains 1 DAGKc domain.
genes like me logo Genes that share domains with AGK: view

No data available for Gene Families for AGK Gene

Function for AGK Gene

Molecular function for AGK Gene

UniProtKB/Swiss-Prot CatalyticActivity: ATP + acylglycerol = ADP + acyl-sn-glycerol 3-phosphate
UniProtKB/Swiss-Prot CatalyticActivity: ATP + 1,2-diacyl-sn-glycerol = ADP + 1,2-diacyl-sn-glycerol 3-phosphate
UniProtKB/Swiss-Prot Function: Lipid kinase that can phosphorylate both monoacylglycerol and diacylglycerol to form lysophosphatidic acid (LPA) and phosphatidic acid (PA), respectively. Does not phosphorylate sphingosine. Overexpression increases the formation and secretion of LPA, resulting in transactivation of EGFR and activation of the downstream MAPK signaling pathway, leading to increased cell growth.

Enzyme Numbers (IUBMB) for AGK Gene

Gene Ontology (GO) - Molecular Function for AGK Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001727 lipid kinase activity --
GO:0001729 ceramide kinase activity IEA --
GO:0003951 NAD+ kinase activity IEA --
GO:0004143 diacylglycerol kinase activity IEA --
GO:0005524 ATP binding IEA --
genes like me logo Genes that share ontologies with AGK: view

Animal Model Products

CRISPR Products

miRNA for AGK Gene

No data available for Phenotypes , Animal Models , Transcription Factor Targeting and HOMER Transcription for AGK Gene

Localization for AGK Gene

Subcellular locations from UniProtKB/Swiss-Prot for AGK Gene

Mitochondrion membrane.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for AGK Gene COMPARTMENTS Subcellular localization image for AGK gene
Compartment Confidence
mitochondrion 5
cytosol 2
nucleus 1
peroxisome 1

Gene Ontology (GO) - Cellular Components for AGK Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005739 mitochondrion IDA --
GO:0016020 membrane --
GO:0031966 mitochondrial membrane IEA --
GO:0043231 intracellular membrane-bounded organelle IDA --
genes like me logo Genes that share ontologies with AGK: view

Pathways for AGK Gene

genes like me logo Genes that share pathways with AGK: view

Pathways by source for AGK Gene

2 KEGG pathways for AGK Gene

UniProtKB/Swiss-Prot Q53H12-AGK_HUMAN

  • Pathway: Lipid metabolism; glycerolipid metabolism

Interacting Proteins for AGK Gene

Gene Ontology (GO) - Biological Process for AGK Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007205 protein kinase C-activating G-protein coupled receptor signaling pathway IEA --
GO:0016310 phosphorylation --
GO:0046486 glycerolipid metabolic process IEA --
GO:0046513 ceramide biosynthetic process IEA --
GO:0046834 lipid phosphorylation IEA --
genes like me logo Genes that share ontologies with AGK: view

Compounds for AGK Gene

(928) HMDB Compounds for AGK Gene

Compound Synonyms Cas Number PubMed IDs
2-Arachidonylglycerol
  • 2-Arachidonyl glycerol
53847-30-6
DG(14:0/14:0/0:0)
  • DAG(14:0/14:0)
Not Available
DG(14:0/14:1(9Z)/0:0)
  • DAG(14:0/14:1)
Not Available
DG(14:0/15:0/0:0)
  • Diacylglycerol(29:0)
Not Available
DG(14:0/16:0/0:0)
  • DAG(30:0)
Not Available

(38) Novoseek inferred chemical compound relationships for AGK Gene

Compound -log(P) Hits PubMed IDs
phosphoinositide 86.2 44
phosphatidylinositol 85.1 54
lipid 84.1 177
wortmannin 76.7 14
ptdins(3)p 75.9 1
genes like me logo Genes that share compounds with AGK: view

Transcripts for AGK Gene

Unigene Clusters for AGK Gene

Acylglycerol kinase:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for AGK

Primer Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for AGK Gene

No ASD Table

Relevant External Links for AGK Gene

GeneLoc Exon Structure for
AGK
ECgene alternative splicing isoforms for
AGK

Expression for AGK Gene

mRNA expression in normal human tissues for AGK Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Integrated Proteomics: protein expression from ProteomicsDB, MOPED, and MaxQB for AGK Gene

SOURCE GeneReport for Unigene cluster for AGK Gene Hs.743318

mRNA Expression by UniProt/SwissProt for AGK Gene

Q53H12-AGK_HUMAN
Tissue specificity: Highly expressed in muscle, heart, kidney and brain.
genes like me logo Genes that share expressions with AGK: view

In Situ Assay Products

No data available for mRNA differential expression in normal tissues for AGK Gene

Orthologs for AGK Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for AGK Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia AGK 35
  • 99.61 (n)
  • 99.29 (a)
AGK 36
  • 99 (a)
OneToOne
cow
(Bos Taurus)
Mammalia AGK 35
  • 89.68 (n)
  • 91.43 (a)
AGK 36
  • 92 (a)
OneToOne
dog
(Canis familiaris)
Mammalia AGK 35
  • 91.13 (n)
  • 92.16 (a)
AGK 36
  • 92 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Agk 35
  • 87.73 (n)
  • 91.92 (a)
Agk 16
Agk 36
  • 92 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia AGK 36
  • 82 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia AGK 36
  • 73 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Agk 35
  • 86.94 (n)
  • 90.97 (a)
chicken
(Gallus gallus)
Aves AGK 35
  • 75 (n)
  • 75.48 (a)
AGK 36
  • 69 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia AGK 36
  • 72 (a)
OneToOne
African clawed frog
(Xenopus laevis)
Amphibia MGC52920 35
tropical clawed frog
(Silurana tropicalis)
Amphibia agk 35
  • 68.98 (n)
  • 68.82 (a)
Str.15995 35
zebrafish
(Danio rerio)
Actinopterygii agk 35
  • 60.42 (n)
  • 61.31 (a)
agk 36
  • 59 (a)
OneToOne
wufi38e09 35
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP005825 35
  • 44.02 (n)
  • 33.33 (a)
fruit fly
(Drosophila melanogaster)
Insecta Mulk 35
  • 43.95 (n)
  • 30.55 (a)
Mulk 36
  • 26 (a)
OneToOne
worm
(Caenorhabditis elegans)
Secernentea F52C9.3 36
  • 21 (a)
OneToOne
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes LCB4 36
  • 11 (a)
ManyToMany
LCB5 36
  • 10 (a)
ManyToMany
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 32 (a)
OneToOne
Species with no ortholog for AGK:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for AGK Gene

ENSEMBL:
Gene Tree for AGK (if available)
TreeFam:
Gene Tree for AGK (if available)

Paralogs for AGK Gene

Paralogs for AGK Gene

Selected SIMAP similar genes for AGK Gene using alignment to 4 proteins:

Pseudogenes.org Pseudogenes for AGK Gene

genes like me logo Genes that share paralogs with AGK: view

Variants for AGK Gene

Sequence variations from dbSNP and Humsavar for AGK Gene

SNP ID Clin Chr 07 pos Sequence Context AA Info Type MAF
rs3779086 -- 141,643,287(-) TAAAC(A/G)TGTGC intron-variant
rs3924731 -- 141,606,502(-) actgc(C/T)ctaaa intron-variant
rs4298424 -- 141,567,425(+) TACTG(G/T)ATTTA intron-variant
rs4548091 -- 141,562,274(+) taatg(G/T)cctga intron-variant
rs4588773 -- 141,567,406(+) GGAGG(G/T)TCTAT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for AGK Gene

Variant ID Type Subtype PubMed ID
esv34135 CNV Loss 18971310
esv2666672 CNV Deletion 23128226
esv268124 CNV Insertion 20981092
nsv510118 CNV Loss 20534489

Relevant External Links for AGK Gene

HapMap Linkage Disequilibrium report
AGK
Human Gene Mutation Database (HGMD)
AGK

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for AGK Gene

Disorders for AGK Gene

MalaCards: The human disease database

MalaCards: The human disease database. (3) Diseases for AGK Gene including...

Search for AGK Gene in MalaCards »

(2) OMIM Diseases for AGK Gene (610345)

UniProtKB/Swiss-Prot

AGK_HUMAN
  • Mitochondrial DNA depletion syndrome 10 (MTDPS10) [MIM:212350]: An autosomal recessive mitochondrial disorder characterized by congenital cataracts, hypertrophic cardiomyopathy, skeletal myopathy, exercise intolerance, and lactic acidosis. Mental development is normal, but affected individuals may die early from cardiomyopathy. {ECO:0000269 PubMed:22277967, ECO:0000269 PubMed:22284826}. Note=The disease is caused by mutations affecting the gene represented in this entry.
  • Cataract 38 (CTRCT38) [MIM:614691]: An opacification of the crystalline lens of the eye becoming evident at birth. It frequently results in visual impairment or blindness. Opacities vary in morphology, are often confined to a portion of the lens, and may be static or progressive. In general, the more posteriorly located and dense an opacity, the greater the impact on visual function. {ECO:0000269 PubMed:22415731}. Note=The disease is caused by mutations affecting the gene represented in this entry.

(9) Novoseek inferred disease relationships for AGK Gene

Disease -log(P) Hits PubMed IDs
cancer 32.2 11
erythroleukemia 21.8 1
tumors 6.37 7
inflammation 1.99 3
pheochromocytoma 0.784 2

Relevant External Links for AGK

Genetic Association Database (GAD)
AGK
Human Genome Epidemiology (HuGE) Navigator
AGK
genes like me logo Genes that share disorders with AGK: view

Publications for AGK Gene

  1. A novel acylglycerol kinase that produces lysophosphatidic acid modulates cross talk with EGFR in prostate cancer cells. (PMID: 15939762) Bektas M. … Spiegel S. (J. Cell Biol. 2005) 2 3 4 23
  2. MuLK, a eukaryotic multi-substrate lipid kinase. (PMID: 15252046) Waggoner D.W. … Bajjalieh S.M. (J. Biol. Chem. 2004) 2 3 23
  3. The DNA sequence of human chromosome 7. (PMID: 12853948) Hillier L.W. … Wilson R.K. (Nature 2003) 3 4
  4. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4
  5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4

Products for AGK Gene

  • Addgene plasmids for AGK

Sources for AGK Gene

Back to Top

Content