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Aliases for AGFG2 Gene

Aliases for AGFG2 Gene

  • ArfGAP With FG Repeats 2 2 3
  • Rev/Rex Activation Domain-Binding Protein Related 3 4
  • HIV-1 Rev-Binding Protein-Like Protein 3 4
  • HRBL 3 4
  • RABR 3 4
  • Arf-GAP Domain And FG Repeats-Containing Protein 2 3
  • Rev/Rex Activation Domain Binding Protein-Related 3
  • HIV-1 Rev Binding Protein-Like 2
  • Nucleoporin 3
  • RAB-R 4

External Ids for AGFG2 Gene

Previous HGNC Symbols for AGFG2 Gene

  • HRBL

Previous GeneCards Identifiers for AGFG2 Gene

  • GC07P099976
  • GC07P100136
  • GC07P094769

Summaries for AGFG2 Gene

Entrez Gene Summary for AGFG2 Gene

  • This gene is a member of the HIV-1 Rev binding protein (HRB) family and encodes a protein with one Arf-GAP zinc finger domain, several phe-gly (FG) motifs, and four asn-pro-phe (NPF) motifs. This protein interacts with Eps15 homology (EH) domains and plays a role in the Rev export pathway, which mediates the nucleocytoplasmic transfer of proteins and RNAs. Alternatively spliced transcript variants have been described, but their biological validity has not been determined. [provided by RefSeq, Feb 2013]

GeneCards Summary for AGFG2 Gene

AGFG2 (ArfGAP With FG Repeats 2) is a Protein Coding gene. Diseases associated with AGFG2 include hiv-1. An important paralog of this gene is AGFG1.

Gene Wiki entry for AGFG2 Gene

No data available for UniProtKB/Swiss-Prot , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for AGFG2 Gene

Genomics for AGFG2 Gene

Regulatory Elements for AGFG2 Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for AGFG2 Gene

Chromosome:
7
Start:
100,539,211 bp from pter
End:
100,568,220 bp from pter
Size:
29,010 bases
Orientation:
Plus strand

Genomic View for AGFG2 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for AGFG2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for AGFG2 Gene

Proteins for AGFG2 Gene

  • Protein details for AGFG2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    O95081-AGFG2_HUMAN
    Recommended name:
    Arf-GAP domain and FG repeat-containing protein 2
    Protein Accession:
    O95081
    Secondary Accessions:
    • O75429
    • Q96AB9
    • Q96GL4

    Protein attributes for AGFG2 Gene

    Size:
    481 amino acids
    Molecular mass:
    48963 Da
    Quaternary structure:
    • Interacts with EPS15R.
    SequenceCaution:
    • Sequence=AAC78803.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};

    Alternative splice isoforms for AGFG2 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for AGFG2 Gene

Proteomics data for AGFG2 Gene at MOPED

Post-translational modifications for AGFG2 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for AGFG2 Gene

ENSEMBL proteins:
REFSEQ proteins:

Antibody Products

No data available for DME Specific Peptides for AGFG2 Gene

Domains & Families for AGFG2 Gene

Gene Families for AGFG2 Gene

HGNC:

Protein Domains for AGFG2 Gene

Graphical View of Domain Structure for InterPro Entry

O95081

UniProtKB/Swiss-Prot:

AGFG2_HUMAN :
  • Contains FG repeats and 4 N-P-F repeats
Domain:
  • Contains FG repeats and 4 N-P-F repeats
  • Contains 1 Arf-GAP domain.
genes like me logo Genes that share domains with AGFG2: view

Function for AGFG2 Gene

Gene Ontology (GO) - Molecular Function for AGFG2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003674 molecular_function ND --
GO:0005096 GTPase activator activity IEA --
GO:0046872 metal ion binding IEA --
genes like me logo Genes that share ontologies with AGFG2: view
genes like me logo Genes that share phenotypes with AGFG2: view

Animal Model Products

CRISPR Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for AGFG2

In Situ Assay Products

Flow Cytometry Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Animal Models , Transcription Factor Targets and HOMER Transcription for AGFG2 Gene

Localization for AGFG2 Gene

Gene Ontology (GO) - Cellular Components for AGFG2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0016020 membrane IDA 19946888
genes like me logo Genes that share ontologies with AGFG2: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Subcellular locations from COMPARTMENTS for AGFG2 Gene

Pathways & Interactions for AGFG2 Gene

SuperPathways for AGFG2 Gene

No Data Available

Interacting Proteins for AGFG2 Gene

Gene Ontology (GO) - Biological Process for AGFG2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0008150 biological_process ND --
GO:0043547 positive regulation of GTPase activity IEA --
genes like me logo Genes that share ontologies with AGFG2: view

No data available for Pathways by source and SIGNOR curated interactions for AGFG2 Gene

Drugs & Compounds for AGFG2 Gene

No Compound Related Data Available

Transcripts for AGFG2 Gene

Unigene Clusters for AGFG2 Gene

ArfGAP with FG repeats 2:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for AGFG2

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for AGFG2 Gene

ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5 ^ 6a · 6b ^ 7 ^ 8 ^ 9 ^ 10 ^ 11 ^ 12 ^ 13
SP1: - -
SP2: - -
SP3: -

Relevant External Links for AGFG2 Gene

GeneLoc Exon Structure for
AGFG2
ECgene alternative splicing isoforms for
AGFG2

Expression for AGFG2 Gene

mRNA expression in normal human tissues for AGFG2 Gene

Protein differential expression in normal tissues from HIPED for AGFG2 Gene

This gene is overexpressed in Skin (31.8), CD4 Tcells (9.0), and Cervix (6.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MOPED, and MaxQB for AGFG2 Gene



SOURCE GeneReport for Unigene cluster for AGFG2 Gene Hs.521083

genes like me logo Genes that share expression patterns with AGFG2: view

Protein tissue co-expression partners for AGFG2 Gene

Primer Products

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for AGFG2 Gene

Orthologs for AGFG2 Gene

This gene was present in the common ancestor of animals.

Orthologs for AGFG2 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia AGFG2 36
  • 98 (a)
OneToOne
AGFG2 35
  • 99.17 (n)
  • 99.17 (a)
platypus
(Ornithorhynchus anatinus)
Mammalia AGFG2 36
  • 61 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Agfg2 36
  • 81 (a)
OneToOne
Agfg2 16
Agfg2 35
  • 82.56 (n)
  • 82.98 (a)
oppossum
(Monodelphis domestica)
Mammalia AGFG2 36
  • 67 (a)
OneToOne
dog
(Canis familiaris)
Mammalia AGFG2 36
  • 86 (a)
OneToOne
AGFG2 35
  • 88.96 (n)
  • 86.67 (a)
cow
(Bos Taurus)
Mammalia AGFG2 36
  • 87 (a)
OneToOne
AGFG2 35
  • 88.94 (n)
  • 89.74 (a)
lizard
(Anolis carolinensis)
Reptilia AGFG2 36
  • 54 (a)
OneToOne
zebrafish
(Danio rerio)
Actinopterygii AGFG2 36
  • 28 (a)
OneToOne
fruit fly
(Drosophila melanogaster)
Insecta drongo 36
  • 16 (a)
OneToMany
Species with no ortholog for AGFG2:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for AGFG2 Gene

ENSEMBL:
Gene Tree for AGFG2 (if available)
TreeFam:
Gene Tree for AGFG2 (if available)

Paralogs for AGFG2 Gene

Paralogs for AGFG2 Gene

(2) SIMAP similar genes for AGFG2 Gene using alignment to 2 proteins:

genes like me logo Genes that share paralogs with AGFG2: view

Variants for AGFG2 Gene

Sequence variations from dbSNP and Humsavar for AGFG2 Gene

SNP ID Clin Chr 07 pos Sequence Context AA Info Type MAF
rs200118629 -- 100,555,261(+) GTGTG(G/T)GGTTT intron-variant
rs200167830 -- 100,563,939(+) GCAGA(C/T)CCCGC reference, missense
rs200180787 -- 100,556,567(+) CCCAC(C/G/T)CTTCT intron-variant
rs200260850 -- 100,564,173(+) CTGCA(A/G)GAAGG intron-variant
rs200376951 -- 100,539,189(+) CAGGA(A/C)GGGCA upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for AGFG2 Gene

Variant ID Type Subtype PubMed ID
esv2734888 CNV Deletion 23290073
dgv7398n71 CNV Loss 21882294
nsv888779 CNV Loss 21882294
dgv7399n71 CNV Loss 21882294
dgv7400n71 CNV Loss 21882294
nsv831072 CNV Loss 17160897

Variation tolerance for AGFG2 Gene

Residual Variation Intolerance Score: 67.34% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 4.74; 66.45% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for AGFG2 Gene

HapMap Linkage Disequilibrium report
AGFG2

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for AGFG2 Gene

Disorders for AGFG2 Gene

MalaCards: The human disease database

(1) MalaCards diseases for AGFG2 Gene - From: GeneCards

Disorder Aliases PubMed IDs
hiv-1
  • aids, slow progression to
- elite association
Search AGFG2 in MalaCards View complete list of genes associated with diseases

Relevant External Links for AGFG2

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
AGFG2
genes like me logo Genes that share disorders with AGFG2: view

No data available for UniProtKB/Swiss-Prot and Genatlas for AGFG2 Gene

Publications for AGFG2 Gene

  1. The eps15 homology (EH) domain-based interaction between eps15 and hrb connects the molecular machinery of endocytosis to that of nucleocytosolic transport. (PMID: 10613896) Doria M. … Di Fiore P.P. (J. Cell Biol. 1999) 23 67
  2. Large-scale sequencing of two regions in human chromosome 7q22: analysis of 650 kb of genomic sequence around the EPO and CUTL1 loci reveals 17 genes. (PMID: 9799793) Gloeckner G. … Rosenthal A. (Genome Res. 1998) 2 67
  3. Genome-wide shRNA screening identifies host factors involved in early endocytic events for HIV-1-induced CD4 down-regulation. (PMID: 25496667) Landi A. … Verhasselt B. (Retrovirology 2014) 67
  4. Intersectin (ITSN) family of scaffolds function as molecular hubs in protein interaction networks. (PMID: 22558309) Wong K.A. … O'Bryan J.P. (PLoS ONE 2012) 67
  5. Initial characterization of the human central proteome. (PMID: 21269460) Burkard T.R. … Colinge J. (BMC Syst. Biol. 2011) 67

Products for AGFG2 Gene

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