Aliases for AGFG1 Gene
External Ids for AGFG1 Gene
Previous HGNC Symbols for AGFG1 Gene
Previous GeneCards Identifiers for AGFG1 Gene
The protein encoded by this gene is related to nucleoporins, a class of proteins that mediate nucleocytoplasmic transport. The encoded protein binds the activation domain of the human immunodeficiency virus Rev protein when Rev is assembled onto its RNA target, and is required for the nuclear export of Rev-directed RNAs. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Sep 2008]
GeneCards Summary for AGFG1 Gene
AGFG1 (ArfGAP With FG Repeats 1) is a Protein Coding gene. Diseases associated with AGFG1 include Choroideremia and Hiv-1. Among its related pathways are Clathrin-mediated endocytosis and Vesicle-mediated transport. GO annotations related to this gene include RNA binding. An important paralog of this gene is AGFG2.
UniProtKB/Swiss-Prot for AGFG1 Gene
Required for vesicle docking or fusion during acrosome biogenesis (By similarity). May play a role in RNA trafficking or localization. In case of infection by HIV-1, acts as a cofactor for viral Rev and promotes movement of Rev-responsive element-containing RNAs from the nuclear periphery to the cytoplasm. This step is essential for HIV-1 replication.