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Aliases for AGFG1 Gene

Aliases for AGFG1 Gene

  • ArfGAP With FG Repeats 1 2 3 5
  • Rev/Rex Activation Domain-Binding Protein 3 4
  • Nucleoporin-Like Protein RIP 3 4
  • HIV-1 Rev Binding Protein 2 3
  • HIV-1 Rev-Binding Protein 3 4
  • Rev-Interacting Protein 3 4
  • HRB 3 4
  • RAB 3 4
  • RIP 3 4
  • Arf-GAP Domain And FG Repeats-Containing Protein 1 3
  • Rab, Rev/Rex Activation Domain-Binding Protein 3
  • HRIP, Rev Interacting Protein 3

External Ids for AGFG1 Gene

Previous HGNC Symbols for AGFG1 Gene

  • HRB

Previous GeneCards Identifiers for AGFG1 Gene

  • GC02P228046
  • GC02P228336
  • GC02P220179

Summaries for AGFG1 Gene

Entrez Gene Summary for AGFG1 Gene

  • The protein encoded by this gene is related to nucleoporins, a class of proteins that mediate nucleocytoplasmic transport. The encoded protein binds the activation domain of the human immunodeficiency virus Rev protein when Rev is assembled onto its RNA target, and is required for the nuclear export of Rev-directed RNAs. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Sep 2008]

GeneCards Summary for AGFG1 Gene

AGFG1 (ArfGAP With FG Repeats 1) is a Protein Coding gene. Diseases associated with AGFG1 include choroideremia and hiv-1. Among its related pathways are Influenza A. GO annotations related to this gene include RNA binding. An important paralog of this gene is AGFG2.

UniProtKB/Swiss-Prot for AGFG1 Gene

  • Required for vesicle docking or fusion during acrosome biogenesis (By similarity). May play a role in RNA trafficking or localization. In case of infection by HIV-1, acts as a cofactor for viral Rev and promotes movement of Rev-responsive element-containing RNAs from the nuclear periphery to the cytoplasm. This step is essential for HIV-1 replication.

Gene Wiki entry for AGFG1 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for AGFG1 Gene

Genomics for AGFG1 Gene

Regulatory Elements for AGFG1 Gene

Promoters for AGFG1 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around AGFG1 on UCSC Golden Path with GeneCards custom track

Genomic Location for AGFG1 Gene

Chromosome:
2
Start:
227,472,152 bp from pter
End:
227,561,222 bp from pter
Size:
89,071 bases
Orientation:
Plus strand

Genomic View for AGFG1 Gene

Genes around AGFG1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
AGFG1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for AGFG1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for AGFG1 Gene

Proteins for AGFG1 Gene

  • Protein details for AGFG1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P52594-AGFG1_HUMAN
    Recommended name:
    Arf-GAP domain and FG repeat-containing protein 1
    Protein Accession:
    P52594
    Secondary Accessions:
    • B3KUL1
    • E9PHX7
    • Q15277
    • Q4VAS0
    • Q4VAS1
    • Q4VAS3
    • Q53QT8
    • Q53R11

    Protein attributes for AGFG1 Gene

    Size:
    562 amino acids
    Molecular mass:
    58260 Da
    Quaternary structure:
    • Interacts with EPS15R and EPS15. Interacts with FCHO1.
    SequenceCaution:
    • Sequence=BAG53473.1; Type=Miscellaneous discrepancy; Note=Aberrant splicing within exon 1.; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for AGFG1 Gene

    Alternative splice isoforms for AGFG1 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for AGFG1 Gene

Proteomics data for AGFG1 Gene at MOPED

Post-translational modifications for AGFG1 Gene

Antibody Products

No data available for DME Specific Peptides for AGFG1 Gene

Domains & Families for AGFG1 Gene

Gene Families for AGFG1 Gene

Protein Domains for AGFG1 Gene

Suggested Antigen Peptide Sequences for AGFG1 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

P52594

UniProtKB/Swiss-Prot:

AGFG1_HUMAN :
  • Contains FG repeats. The FG repeat region is required for acting as a cofactor of HIV-1 Rev.
Domain:
  • Contains FG repeats. The FG repeat region is required for acting as a cofactor of HIV-1 Rev.
  • Contains 1 Arf-GAP domain.
genes like me logo Genes that share domains with AGFG1: view

Function for AGFG1 Gene

Molecular function for AGFG1 Gene

UniProtKB/Swiss-Prot Function:
Required for vesicle docking or fusion during acrosome biogenesis (By similarity). May play a role in RNA trafficking or localization. In case of infection by HIV-1, acts as a cofactor for viral Rev and promotes movement of Rev-responsive element-containing RNAs from the nuclear periphery to the cytoplasm. This step is essential for HIV-1 replication.
genes like me logo Genes that share phenotypes with AGFG1: view

Animal Models for AGFG1 Gene

MGI Knock Outs for AGFG1:

Animal Model Products

Inhibitory RNA Products

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for AGFG1 Gene

Localization for AGFG1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for AGFG1 Gene

Nucleus. Cytoplasmic vesicle.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for AGFG1 Gene COMPARTMENTS Subcellular localization image for AGFG1 gene
Compartment Confidence
nucleus 5
cytosol 3
endosome 2
golgi apparatus 2
lysosome 2
plasma membrane 2
vacuole 2
cytoskeleton 1
endoplasmic reticulum 1

Gene Ontology (GO) - Cellular Components for AGFG1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0042995 cell projection IEA --
genes like me logo Genes that share ontologies with AGFG1: view

Pathways & Interactions for AGFG1 Gene

SuperPathways for AGFG1 Gene

Superpath Contained pathways
1 Influenza A
genes like me logo Genes that share pathways with AGFG1: view

Pathways by source for AGFG1 Gene

1 KEGG pathway for AGFG1 Gene

Gene Ontology (GO) - Biological Process for AGFG1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007275 multicellular organism development IEA --
GO:0043547 positive regulation of GTPase activity IEA --
genes like me logo Genes that share ontologies with AGFG1: view

No data available for SIGNOR curated interactions for AGFG1 Gene

Drugs & Compounds for AGFG1 Gene

(19) Drugs for AGFG1 Gene - From: Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials

(10) Additional Compounds for AGFG1 Gene - From: Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
genes like me logo Genes that share compounds with AGFG1: view

Transcripts for AGFG1 Gene

Unigene Clusters for AGFG1 Gene

ArfGAP with FG repeats 1:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for AGFG1 Gene

ExUns: 1a · 1b ^ 2 ^ 3 ^ 4 ^ 5a · 5b ^ 6a · 6b ^ 7 ^ 8 ^ 9 ^ 10a · 10b ^ 11 ^ 12 ^ 13 ^ 14a · 14b
SP1: -
SP2: -
SP3:
SP4:
SP5: - -

Relevant External Links for AGFG1 Gene

GeneLoc Exon Structure for
AGFG1
ECgene alternative splicing isoforms for
AGFG1

Expression for AGFG1 Gene

mRNA expression in normal human tissues for AGFG1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for AGFG1 Gene

This gene is overexpressed in Whole Blood (x8.1).

Protein differential expression in normal tissues from HIPED for AGFG1 Gene

This gene is overexpressed in Peripheral blood mononuclear cells (10.8), Monocytes (6.8), CD8 Tcells (6.5), and Bone marrow stromal cell (6.5).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for AGFG1 Gene



SOURCE GeneReport for Unigene cluster for AGFG1 Gene Hs.352962

mRNA Expression by UniProt/SwissProt for AGFG1 Gene

P52594-AGFG1_HUMAN
Tissue specificity: Ubiquitously expressed.
genes like me logo Genes that share expression patterns with AGFG1: view

Protein tissue co-expression partners for AGFG1 Gene

Primer Products

In Situ Assay Products

Orthologs for AGFG1 Gene

This gene was present in the common ancestor of animals.

Orthologs for AGFG1 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia AGFG1 35
  • 95.77 (n)
  • 98.21 (a)
AGFG1 36
  • 98 (a)
OneToOne
dog
(Canis familiaris)
Mammalia AGFG1 35
  • 95.6 (n)
  • 97.09 (a)
AGFG1 36
  • 97 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Agfg1 35
  • 92.73 (n)
  • 96.78 (a)
Agfg1 16
Agfg1 36
  • 97 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia AGFG1 35
  • 99.64 (n)
  • 99.64 (a)
AGFG1 36
  • 100 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Agfg1 35
  • 92.9 (n)
  • 96.24 (a)
oppossum
(Monodelphis domestica)
Mammalia AGFG1 36
  • 92 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia AGFG1 36
  • 85 (a)
OneToOne
chicken
(Gallus gallus)
Aves AGFG1 35
  • 84.19 (n)
  • 86.13 (a)
AGFG1 36
  • 86 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia AGFG1 36
  • 86 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia agfg1 35
  • 74.48 (n)
  • 77.91 (a)
Str.10746 35
African clawed frog
(Xenopus laevis)
Amphibia Xl.31956 35
zebrafish
(Danio rerio)
Actinopterygii agfg1a 35
  • 66.3 (n)
  • 66.73 (a)
hrb 35
agfg1a 36
  • 41 (a)
OneToMany
agfg1b 36
  • 58 (a)
OneToMany
fruit fly
(Drosophila melanogaster)
Insecta drongo 36
  • 21 (a)
OneToMany
Species with no ortholog for AGFG1:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for AGFG1 Gene

ENSEMBL:
Gene Tree for AGFG1 (if available)
TreeFam:
Gene Tree for AGFG1 (if available)

Paralogs for AGFG1 Gene

Paralogs for AGFG1 Gene

(3) SIMAP similar genes for AGFG1 Gene using alignment to 4 proteins:

genes like me logo Genes that share paralogs with AGFG1: view

Variants for AGFG1 Gene

Sequence variations from dbSNP and Humsavar for AGFG1 Gene

SNP ID Clin Chr 02 pos Sequence Context AA Info Type
rs1359 -- 227,556,495(-) AGGAA(A/G)TCCTC utr-variant-3-prime
rs9973 -- 227,554,749(+) ATTGC(A/G)GATAC utr-variant-3-prime
rs12866 -- 227,555,048(+) GAGGG(A/T)TACCT utr-variant-3-prime
rs1135969 -- 227,520,019(+) CCACA(A/G)AAAGT reference, synonymous-codon
rs4130464 -- 227,477,962(+) TGTCA(C/T)GCTTT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for AGFG1 Gene

Variant ID Type Subtype PubMed ID
nsv834560 CNV Loss 17160897
esv259807 OTHER Complex 20981092
nsv834561 CNV Gain 17160897

Variation tolerance for AGFG1 Gene

Residual Variation Intolerance Score: 17.9% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.71; 32.57% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for AGFG1 Gene

HapMap Linkage Disequilibrium report
AGFG1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for AGFG1 Gene

Disorders for AGFG1 Gene

MalaCards: The human disease database

(7) MalaCards diseases for AGFG1 Gene - From: DISEASES, Novoseek, and GeneCards

Disorder Aliases PubMed IDs
choroideremia
  • choroidal sclerosis
hiv-1
  • aids, slow progression to
griscelli syndrome, type 2
  • griscelli syndrome type 2
jensen syndrome
  • opticoacoustic nerve atrophy with dementia
progressive bulbar palsy
  • progressive bulbar atrophy
- elite association - COSMIC cancer census association via MalaCards
Search AGFG1 in MalaCards View complete list of genes associated with diseases

Relevant External Links for AGFG1

Genetic Association Database (GAD)
AGFG1
Human Genome Epidemiology (HuGE) Navigator
AGFG1
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
AGFG1
genes like me logo Genes that share disorders with AGFG1: view

No data available for UniProtKB/Swiss-Prot and Genatlas for AGFG1 Gene

Publications for AGFG1 Gene

  1. A human nucleoporin-like protein that specifically interacts with HIV Rev. (PMID: 7637788) Fritz C.C. … Green M.R. (Nature 1995) 2 3 4 67
  2. Role of HRB in clathrin-dependent endocytosis. (PMID: 18819912) Chaineau M. … Galli T. (J. Biol. Chem. 2008) 3 23
  3. The eps15 homology (EH) domain-based interaction between eps15 and hrb connects the molecular machinery of endocytosis to that of nucleocytosolic transport. (PMID: 10613896) Doria M. … Di Fiore P.P. (J. Cell Biol. 1999) 3 23
  4. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin E.L. … Gygi S.P. (Cell 2015) 3
  5. The LEF1/CYLD axis and cIAPs regulate RIP1 deubiquitination and trigger apoptosis in selenite-treated colorectal cancer cells. (PMID: 24577083) Wu P. … Xu C.M. (Cell Death Dis 2014) 3

Products for AGFG1 Gene

Sources for AGFG1 Gene

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