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AGER Gene

protein-coding GIFtS: 66

GC06M032256

advanced glycosylation end product-specific receptor
Symbol approved by the HUGO Gene Nomenclature Committee (HGNC) database

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc , and/or ⁷Ensembl, ⁸miRBase)
About This Section

Aliases
MGC22357 ^²
OTTHUMP00000029155 ^²
OTTHUMP00000029156 ^²
RAGE ^¹, ², ³, ⁵

Descriptions
Receptor for advanced glycosylation end products ^³
advanced glycosylation end product-specific receptor ^²
receptor for advanced glycosylation end-products ^²

External Ids
HGNC: 320¹
Entrez Gene: 177²
UniProtKB: Q15109³
Ensembl: ENSG00000204305⁷

Search outside databases for aliases for AGER gene

Previous GC identifers: GC06M032175 GC06M031920 GC06M032220

(According to Entrez Gene, Wikipedia's Gene Wiki,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

EntrezGene summary for AGER:

This gene encodes a member of the immunoglobulin superfamily of cell surface molecules. It is a

receptor for various molecules, including the amyloidogenic form of serum amyloid A, amyloid-beta

protein, members of the S100/calgranulin superfamily and advanced glycation end products. The gene

lies within the major histocompatibility complex (MHC) class III region on chromosome 6.

Alternative splicing results in two transcript variants encoding different isoforms. [provided by

RefSeq]

UniProtKB/Swiss-Prot: RAGE_HUMAN, Q15109

Function: Mediates interactions of advanced glycosylation end products (AGE). These are

nonenzymatically glycosylated proteins which accumulate in vascular tissue in aging and at an

accelerated rate in diabetes. Receptor for amyloid beta peptide

Gene Wiki entry for AGER (RAGE)

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 36),
and/or miRBase,
Genomic Views according to UCSC and Ensembl, Transcription factor binding sites according to SABiosciences)
About This Section

Genomic View:

UCSC Golden Path with GeneCards custom track

Transcription factor binding sites upstream to the AGER gene

Entrez Gene cytogenetic band: 6p21.3 Ensembl cytogenetic band: 6p21.32 HGNC cytogenetic band: 6p21.3

AGER Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)

GeneLoc gene densities for chromosome 6 GeneLoc Exon Structure

GeneLoc location for GC06M032256: (about GC identifiers)

Start:	32,256,723 bp from pter
End:	32,260,001 bp from pter
Size:	3,279 bases
Orientation:	minus strand

2 alternative locations:

Chr6-,c6_COX 32,244,477-32,247,754

Chr6-,c6_QBL 32,249,222-32,252,499

RefSeq DNA sequence:

NC_000006.10 NT_007592.14 NT_113891.1 NT_113896.1

(According to ¹UniProtKB, and/or Ensembl, Phosphorylation sites according to ²Phosphosite, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Enzo Life Sciences, Abnova, OriGene and/or, Abcam,
Biochemical Assays by Invitrogen, Millipore, R&D Systems, Cell Signaling Technology, and/or Enzo Life Sciences, Ontologies according to Gene Ontology Consortium 01 Apr 2009 and Entrez Gene, Antibodies by Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Cell Signaling Technology, Abcam, Abnova, and/or Novus Biologicals)
About This Section

UniProtKB/Swiss-Prot: RAGE_HUMAN, Q15109 (See protein sequence)

Recommended Name: Advanced glycosylation end product-specific receptor precursor

Size: 404 amino acids; 42803 Da

Subcellular location: Isoform 1: Cell membrane; Single-pass type I membrane protein

Subcellular location: Isoform 2: Secreted

PDB structures from and Proteopedia :

1PWI (3D)

2BJP (3D)

2E5E (3D)

2ENS (3D)

3CJJ (3D)

Secondary accessions: Q15279 Q9H2X7 Q9Y3R3

Alternative splicing: 2 isoforms: Q15109-1 Q15109-2

REFSEQ proteins (2 alternative transcripts):

NP_001127.1 NP_751947.1

ENSEMBL proteins:

ENSP00000364195 ENSP00000364196 ENSP00000364199 ENSP00000364201 ENSP00000364208 ENSP00000364217

ENSP00000364211 ENSP00000364206 ENSP00000364210

Human Recombinant Proteins

	Browse Drug Discovery Central at Invitrogen for human recombinant proteins
	Browse Purified and Recombinant Proteins at Millipore
	Browse Human Recombinant Proteins at Sigma-Aldrich
	R&D Systems Recombinant & Natural Proteins for AGER (RAGE)
	Browse recombinant and purified proteins available from Enzo Life Sciences
	Recombinant Proteins from Abcam (RAGE)
	Human Recombinant Proteins from Abnova (AGER)

Browse Origene for full length recombinant human proteins expressed in human HEK293 cells

3 Gene Ontology (GO) cellular component terms (links to tree view):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005576	extracellular region	IEA	--
GO:0005886	plasma membrane	NAS	1378843
GO:0005887	integral to plasma membrane	TAS	1378843

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Antibodies for AGER:

	Browse Antibodies Central at Invitrogen
	Millipore Mono- and Polyclonal Antibodies for the study of AGER
	Sigma-Aldrich Antibodies for AGER
	R&D Systems Antibodies for AGER (RAGE)
	Antibodies from Abcam (RAGE), each with their Abpromise^SM
	Monoclonal and Polyclonal Antibodies from Abnova (AGER)
	Novus Biologicals Antibodies for AGER

Assays for AGER:

	Browse Invitrogen for biochemical assays
	Browse Kits and Assays available from Millipore
	R&D Systems ELISAs for AGER (RAGE) (see all)
	Browse biochemical assays available from Enzo Life Sciences

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

Graphical View of Domain Structure for InterPro Entry Q15109

ProtoNet protein and cluster: Q15109

2 Blocks protein families:

IPB003598 Immunoglobulin C-2 type

IPB013162 CD80-like C2-set immunoglobulin

UniProtKB/Swiss-Prot: RAGE_HUMAN, Q15109

Similarity: Contains 2 Ig-like C2-type (immunoglobulin-like) domains

Similarity: Contains 1 Ig-like V-type (immunoglobulin-like) domain

(According to MGI Jun 06 2009, UniProtKB, IUBMB,and/or Genatlas,
shRNA from OriGene, Sigma-Aldrich, RNAi from Sigma-Aldrich,
RNAi Products, Clones, and Q-PCR Products from Invitrogen, Millipore, OriGene, and/or Abnova, siRNAs from Applied Biosystems, SYBR primers from OriGene, Cell-based Assays from Millipore, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
About This Section

Inhib. RNA:		Invitrogen RNAi Products for gene knock-down (AGER)
		Browse for Gene Knock-down Tools from Millipore
		Abnova Chimera RNAi Products for Gene knock-down (AGER)

OriGene 29mer shRNA kit in GFP-retroviral vectors (see all 2): NM_172197

Applied Biosystems Silencer® siRNAs for AGER

Sigma-Aldrich siRNA and siRNA Panels for AGER

Sigma-Aldrich shRNA for AGER

Explore Sigma-Aldrich super-pooled esiRNAs

Clones:		Invitrogen Clones for AGER
		Browse Clones for the Expression of Recombinant Proteins Available from Millipore

OriGene GFP tagged cDNA clones in CMV expression vector (see all 2): NM_001136
Myc/DDK tagged cDNA clones in CMV expression vector (see all 2): NM_001136
untagged cDNA clones in CMV expression vector (see all 2): NM_001136

Primers:

Browse Quantitative PCR Central at Invitrogen for Q-PCR LUX™ Primers

OriGene genome-wide validated SYBR primer pairs: NM_001136

UniProtKB/Swiss-Prot: RAGE_HUMAN, Q15109

Function: Mediates interactions of advanced glycosylation end products (AGE). These are

nonenzymatically glycosylated proteins which accumulate in vascular tissue in aging and at an

accelerated rate in diabetes. Receptor for amyloid beta peptide

Genatlas biochemistry entry for AGER:

receptor of advanced glycosylation end products of proteins,mediating amyloid beta peptide effect

on neurons and microglia

13 MGI mutant phenotypes (inferred from 3 alleles) (MGI details for Ager):

	behavior/neurological	cellular	growth/size	hematopoietic system
homeostasis/metabolism	immune system	muscle	no phenotypic analysis	normal
renal/urinary system	skeleton	touch/vibrissae

2 Gene Ontology (GO) molecular function terms (links to tree view):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0004888	transmembrane receptor activity	TAS	1378843
GO:0005515	protein binding	IPI	16061848 17474147

About this table

(Pathways according to Invitrogen (maps by GeneGo), Millipore, Cell Signaling Technology, Sigma-Aldrich, KEGG and/or UniProtKB,
Sets of similar genes according to GeneDecks, Proteins Network according to SABiosciences, Interactions according to ¹UniProtKB, ²MINT, and/or ³STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
About This Section

Gene Network Central^TM Interacting Genes and Proteins Network for AGER

5/10 Interacting proteins for AGER (ENSP00000364211³ Q15109^{1, 2}) via UniProtKB, MINT, and/or STRING (see all 10 )

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
S100B	P04271²	STRING (score=.873) MINT-5224202 MINT-5224259 MINT-5224222 MINT-5224235
GRB2	P62993¹	EBI-1646426, EBI-401755
NCK1	P16333¹	EBI-1646426, EBI-389883
S100P	P25815¹	EBI-1646426, EBI-743700
TTR	P02766²	MINT-2635425 MINT-2635447

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2 Gene Ontology (GO) biological process terms (links to tree view):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0006954	inflammatory response	TAS	10399917
GO:0007166	cell surface receptor linked signal transduction	TAS	10835680

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(Chemical Compounds according to UniProtKB, Enzo Life Sciences, Sigma-Aldrich, Tocris Bioscience, and/or Novoseek and Drugs according to Enzo Life Sciences and/or PharmGKB)
About This Section

Browse drugs & compounds from Enzo Life Sciences

Browse Small Molecules at Sigma-Aldrich

Browse Tocris compounds for AGER
10/16 Novoseek chemical compound relationships for AGER gene (see all 16 )

Compound	Score	Articles	PubMed IDs for Articles with Shared Sentences (# sentences)
n(epsilon)-(carboxymethyl)lysine	78.71	15	10531386 (2), 10966490 (2), 15213320 (1), 11700025 (1) (see all 5)
pentosidine	70.62	9	15213278 (1), 11576932 (1), 16315765 (1), 10966490 (1) (see all 5)
3-deoxyglucosone	64.39	2	15213320 (1)
gw9662	58.98	2	17004092 (1), 18855759 (1)
glucose	40.69	13	15770917 (2), 17960513 (2), 15213320 (1), 14670831 (1) (see all 9)
oxygen	30.33	19	15553663 (2), 16712480 (1), 18049312 (1), 18616999 (1) (see all 15)
nadph	26.05	8	15574998 (2), 15830106 (2), 19252229 (1), 15297385 (1) (see all 5)
aldose	23.75	1	16037296 (1)
gdp	11.98	1	15213320 (1)
nitric oxide	8.58	14	18256374 (1), 19252229 (1), 17190908 (1), 15574998 (1) (see all 7)

About this table

(GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 219 Homo sapiens; Jun 2 2009) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView,
non coding RNAs according to RNAdb,
ESTs according to GeneTide,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from Invitrogen, Millipore, and/or Abnova,
siRNAs from Applied Biosystems, Sigma-Aldrich,
shRNA from Sigma-Aldrich, OriGene,
Tagged/untagged cDNA clones from OriGene,
Expression Assays from Applied Biosystems)
About This Section

Inhib. RNA:		Invitrogen RNAi Products for gene knock-down (AGER)
		Browse for Gene Knock-down Tools from Millipore
		Abnova Chimera RNAi Products for Gene knock-down (AGER)

OriGene 29mer shRNA kit in GFP-retroviral vectors (see all 2): NM_172197

Sigma-Aldrich siRNA and siRNA Panels for AGER

Sigma-Aldrich shRNA for AGER

Explore Sigma-Aldrich super-pooled esiRNAs

Applied Biosystems Silencer® siRNAs:

NM_001136 NM_172197

REFSEQ mRNAs for AGER gene (2 alternative transcripts):

NM_001136.3 NM_172197.1

Applied Biosystems TaqMan ® Gene Expression Assays:

NM_001136 NM_172197

               OriGene GFP tagged cDNA clones in CMV expression vector (see all 2): NM_001136
                                 Myc/DDK tagged cDNA clones in CMV expression vector (see all 2): NM_001136
                                 untagged cDNA clones in CMV expression vector (see all 2): NM_001136

Additional cDNA sequence:

AB036432.1 AB061668.1 AB061669.1 AF536236.1 AF536237.1 AF537303.1 AJ133822.1 AK298100.1

AK313178.1 AY755619.1 AY755620.1 AY755621.1 AY755622.1 AY755623.1 AY755624.1 AY755625.1

AY755626.1 AY755627.1 AY755628.1 BC020669.1 DQ104251.1 DQ104252.1 DQ104253.1 DQ104254.1

EU117141.1 EU428811.1 EU428812.1 EU428813.1 EU428814.1 EU428815.1 EU428816.1 EU826616.1

EU826617.1 EU826618.1 EU826619.1 EU826620.1 FJ545655.1 M91211.1

11 DOTS entries:

DT.100642746 DT.121378339 DT.121378379 DT.121378225 DT.121378333 DT.91637899 DT.101985408 DT.95371256

DT.91722873 DT.91722860 DT.97832209

24/307 AceView cDNA sequences (see all 307 ):

BU622208 AB061668 BM992910 BX092491 BM714937 BU521990 BU899237 R78183

BF476466 CR601493 AW177611 AI057090 AW177609 BM547314 AW177610 BF309711

CD722009 CA449935 BF205468 CD615126 CD251257 BM726610 BQ023810 BM702297

highest scoring ESTs for AGER:

M91211 AB036432 AB061668 AB061669 BC020669 BG483796 BG484869 BG506672 BG529831 BG529866

Unigene Cluster for AGER:

Advanced glycosylation end product-specific receptor

Hs.534342 [show with all ESTs]

Unigene Representative Sequence: AK298100

GeneLoc Exon Structure

9 Ensembl transcripts including schematic representations:

ENST00000375055 ENST00000375056 ENST00000375059 ENST00000375061 ENST00000375067 ENST00000375076

ENST00000375070 ENST00000375065 ENST00000375069

(Experimental results according to ¹GeneNote and GNF BioGPS,
probe sets-to-genes annotations according to ²GeneAnnot , ³GeneTide , Sets of similar genes according to GeneDecks, Electronic Northern calculations according to data from UniGene (Build 219 Homo sapiens), SAGE tags according to CGAP, plus additional links to SOURCE, and/or GNF BioGPS, and/or EXPOLDB, and/or UniProtKB,
Expression Assays from Applied Biosystems )
About This Section

AGER expression in normal and diseased human tissues

Applied Biosystems TaqMan ® Gene Expression Assays for AGER

¹ / ² / ³

5 probe-sets matching AGER gene

Affymetrix probe-set	Array	# genes	Sensitivity	Specificity	Correlation	Length	Gb_Accession	Consensus	Uniqueness	Score	Rank
Affymetrix probe-set	Array	GeneAnnot data			GeneNote data		GeneTide data
35868_at²^{, 3}	U95-A	3	1.00	0.33	1.00	1.00	M91211	1.00	0.90	0.95	1
210081_at²^{, 3}	U133-A	3	1.00	0.33	--	--	AB036432	0.80	0.88	0.84	1
217046_s_at²^{, 3}	U133-A	3	1.00	0.33	--	--	AJ133822	0.60	1.00	0.82	1
210081_at²	U133Plus2	3	1.00	0.33	--	--	--	--	--	--	--
217046_s_at²	U133Plus2	3	1.00	0.33	--	--	--	--	--	--	--

GeneDecks AGER for binary patterns associated with the probe-sets selected above

About GeneDecksing

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Data from

(Publications) and GNF BioGPS
About these images
About these images

CGAP SAGE TAG: TGTGTCAGAG

SOURCE GeneReport for Unigene cluster: Hs.534342
Expression variation in blood from EXPOLDB for AGER
UniProtKB/Swiss-Prot: RAGE_HUMAN, Q15109
Tissue specificity: Endothelial cells

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD and/or ⁵MGI Jun 06 2009, with possible further links to Flybase and/or WormBase, Gene Trees according to Ensembl)
About This Section

Orthologs for AGER gene from 5 species

Organism	Gene	Locus	Description	Human Similarity	NCBI accessions
dog (Canis familiaris)	AGER¹	--	advanced glycosylation end product-specific receptor	85.17(n) 80.25(a)	403168 XM_532093.2 XP_532093.2
chimpanzee (Pan troglodytes)	AGER¹	--	advanced glycosylation end product-specific receptor	99.59(n) 98.76(a)	462584 XM_518377.2 XP_518377.2
cow (Bos taurus)	AGER¹	--	advanced glycosylation end product-specific receptor	87.01(n) 83.62(a)	280986 NM_173982.2 NP_776407.1
rat (Rattus norvegicus)	Ager¹	--	advanced glycosylation end product-specific receptor	81.01(n) 78.36(a)	81722 NM_053336.1 NP_445788.1
mouse (Mus musculus)	Ager^{1, 5}	17⁵	advanced glycosylation end product-specific receptor^{1, 5}	81.09(n)¹ 78.61(a)¹	11596¹ NM_007425.2¹ NP_031451.2¹ AB207883⁵ AF030001⁵ (see all 8)

About this table Species with no ortholog for AGER

ENSEMBL Gene Tree for AGER

(Paralogs according to ¹HomoloGene
and ²Ensembl, Pseudogenes according to ³Pseudogene.org)
About This Section

(According to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, and UniProtKB, Linkage Disequilibrium by HapMap, Genotyping Reagents from Applied Biosystems)
About This Section

10/35 NCBI SNPs in AGER are shown (see all 35 )
(Click for Applied Biosystems TaqMan ® Genotyping Assay) (see all 79)

AB	SNP ID	Valid	Chr 6 pos	Sequence	Recs	AA Chg	Type	More	Recs	Pop	Total sample	More
AB	Genomic Data				Transcription Data				Allele Frequencies
				--	--	--		--	--			--
	rs2070600^1,2	C,F,H	32259421(-)	`CCAACG/AGCTCC`	2	S/G	mis¹ ese³		13	EA NA EU WA	2532
	rs1800684^1,2	A,C,F,H	32259972(-)	`ATGGCA/TGCCGG`	2	A/A	syn¹ ese³		7	EU EA WA NA	554
	rs35795092^1,2	F	32259398(+)	`ATCCCG/CACAGC`	2	V/V	syn¹		1	NA	74
--	rs3134940^1,2	A,C,F,H	32257794(-)	`AAAGGA/GACAGA`	2	--	int¹ trp³		7	EU EA WA NA	522
	rs1035798^1,2	A,C,F,H	32259200(-)	`CCACAC/TACAGA`	2	--	int¹		19	EA MN EU WA NS NA	2932
	rs3131300^1,2	A,C,F,H	32259912(+)	`GGTTGA/GGGGAG`	2	--	int¹		9	EU EA WA NS	1004
	rs184003^1,2	C,F,H	32258274(-)	`AACTAG/TCAACA`	2	--	int¹		14	EA NA EU WA	964
	rs2071288^1,2	C,F,H	32257238(-)	`TCTCCG/ATACAG`	2	--	int¹		5	EA EU WA	1902
	rs2269422^1,2	C,F,H	32259272(-)	`CTCTTA/GCCTAA`	2	--	int¹		8	EA NA EU WA	2054
--	rs204996^1,2	C,F	32257861(-)	`CCCCTG/ACCCCA`	2	--	int¹		1	MN	184

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HapMap Linkage Disequilibrium images for AGER (up to first 250kb)

(in which this Gene is Involved, According to OMIM, UniProtKB, Novoseek, PharmGKB, Genatlas, GeneTests, Blood group antigen gene mutations by BGMUT, HGMD, GAD, HuGE Navigator, BCGD, and/or TGDB.)
About This Section

OMIM: 600214

10/58 Novoseek disease relationships for AGER gene (see all 58 )

Disease	Score	Articles	PubMed IDs for Articles with Shared Sentences (# sentences)
diabetic angiopathies	70.78	1	17462779 (1)
diabetic nephropathies	63.66	28	8559486 (4), 16936199 (3), 10966490 (3), 17667983 (2) (see all 11)
atherosclerosis	62.73	31	10421989 (2), 17097822 (2), 19217461 (2), 15666591 (1) (see all 21)
hyperglycemia	62.12	5	11694852 (1), 14670831 (1), 15638868 (1), 9797717 (1) (see all 5)
microangiopathy diabetic	60.52	6	18855759 (2), 15823719 (1), 15224502 (1), 16146671 (1) (see all 5)
diabetic retinopathy	57.01	16	18331234 (2), 16047941 (2), 17251488 (2), 16216433 (1) (see all 12)
diabetes mellitus	54.20	8	18331234 (1), 9044315 (1), 14578938 (1), 9797717 (1)
inflammation	48.61	33	19292913 (3), 17117586 (3), 15213278 (2), 18331236 (1) (see all 24)
vascular diseases	48.12	25	19275767 (5), 7887450 (3), 16356122 (2), 9044300 (1) (see all 9)
glomerulosclerosis	43.83	2	16936199 (1), 11457879 (1)

About this table

Human Gene Mutation Database: AGER
Genetic Association Database: AGER
Human Genome Epidemiology Navigator: AGER (17 documents)

(Possibly Related Articles in Doctor's Guide)
About This Section

(in PubMed. Associations of this gene to articles via ¹Novoseek, ²HGNC, ³Entrez Gene, ⁴UniProtKB/Swiss-Prot, ⁵UniProtKB/TrEMBL, ⁶GAD, and/or ⁷PharmGKB)
About This Section

10/399 PubMed articles for AGER gene (see all 399 ):

Effects of novel polymorphisms in the RAGE gene on transcriptional regulation and their association with diabetic retinopathy. (PubMed id 11375354)^{3, 4, 6} Hudson B.I....Grant P.J. (2001)
Cloning and expression of a cell surface receptor for advanced glycosylation end products of proteins. (PubMed id 1378843)^{1, 3, 4} Neeper M.... Shaw A. (1992)
-429T/C and -374T/A polymorphisms of RAGE gene promoter are not associated with diabetic retinopathy in Chinese patients with type 2 diabetes. (PubMed id 12941744)^{1, 3, 6} JiXiong X....ShuQin L. (2003)
Association of Gly82Ser polymorphism in the RAGE gene with diabetic retinopathy in type II diabetic Asian Indian patients. (PubMed id 12477623)^{1, 3, 6} Kumaramanickavel G....Sharma T. (2002)
Three genes in the human MHC class III region near the junction with the class II: gene for receptor of advanced glycosylation end products, PBX2 homeobox gene and a notch homolog, human counterpart of mouse mammary tumor gene int-3. (PubMed id 7835890)^{1, 3, 4} Sugaya K.... Ikemura T. (1994)
Haplotype analysis of the RAGE gene: identification of a haplotype marker for diabetic nephropathy in type 2 diabetes mellitus. (PubMed id 15790669)^{3, 6} Kankova K....Znojil V. (2005)
The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)^{3, 4} Gerhard D.S....Malek J. (2004)
The functional -374 T/A RAGE gene polymorphism is associated with proteinuria and cardiovascular disease in type 1 diabetic patients. (PubMed id 12606536)^{3, 6} Pettersson-Fernholm K....Groop P.H. (2003)
The DNA sequence and analysis of human chromosome 6. (PubMed id 14574404)^{3, 4} Mungall A.J.... Beck S. (2003)
The - 429 T/C and - 374 T/A gene polymorphisms of the receptor of advanced glycation end products gene are not risk factors for diabetic retinopathy in Caucasians with type 2 diabetes. (PubMed id 14704946)^{3, 6} Globocnik Petrovic M....Petrovic D. (2003)

(in PubMed, OMIM, and NCBI Bookshelf)
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		AND	OR
Aliases
Free Text

Query String		PubMed OMIM NCBI Bookshelf
	(Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, and/or H-InvDB)
About This Section

Entrez Gene: 177	HGNC: 320	AceView: AGERandPBX2	Ensembl:ENSG00000204305	euGenes: HUgn177
ECgene: AGER	H-InvDB: AGER

(According to HUGE)
About This Section

(According to ATLAS, HORDE, IMGT, MTDB, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section

Name	Description
ATLAS Chromosomes in Cancer entry for AGER	Genetics and Cytogenetics in Oncology and Haematology

Licensable Technologies for AGER
(Available from WIS Yeda, Salk, Tufts)

About This Section

(Reagents available from Applied Biosystems, Antibodies and assays by Cell Signaling Technology, Abcam, Novus Biologicals,
Sigma-Aldrich, R&D Systems, Millipore, Abnova, and/or Invitrogen, Clones available from OriGene,and/or Invitrogen, Drugs and/or compounds by Sigma-Aldrich,
Enzo Life Sciences, and/or Tocris Bioscience)
About This Section

Products for AGER:

TaqMan ® Gene Expression Assays

TaqMan ® Genotyping Assays

Free SNP selection tool

Invitrogen iPath Pathways	Invitrogen BLOCK-iT™ RNAi
Invitrogen Antibodies	Invitrogen Assays
Invitrogen Clones	Invitrogen Q-PCR Products
Invitrogen Human Recombinant Kinases	Invitrogen Custom Antibody and Peptide Service
Invitrogen Proteins / Assays / Screening Services	Search Invitrogen catalog for AGER-related products

	Millipore Custom Antibody & Bulk Services
	Millipore Preclinical / Clinical Development Services
	Millipore Immunoassay Services
	Millipore Target Screening & Profiling Services

	Predesigned and custom siRNAs for AGER		Antibodies for AGER
	Explore super-pooled esiRNAs		Browse proteins at Sigma-Aldrich
	Lentivirus-delivered shRNAs for AGER		Browse small molecules at Sigma-Aldrich
	"Your Favorite Gene" Pathways		feedback

	Antibodies		Primer Pairs
	Cell Culture Products		ELISAs
	Flow Cytometry Kits		Protease Activity Assays & Reagents
	Cell Selection/Detection Kits & Reagents		ELISA/Assay Development Kits & Reagents
	Multiplex/Array Assay Kits & Reagents		ELISpot Kits & Development Modules
	Recombinant & Natural Proteins

	Recombinant Proteins (AGER)
	Antibodies (AGER)
	Chimera RNAi (AGER)
	Custom Service for Mouse Mab
	Custom Service for Rabbit Pab from Full-length Protein

Search for Antibodies & Assays

	Recombinant Proteins (RAGE)
	Antibodies (RAGE)

Search OriGene for AGER

Search Tocris compounds for AGER

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Antibodies for AGER

GeneCards Homepage - Last full update: 2 Jul 2009 Incremental update: 13 Oct 2009

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Gene Index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

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AGER Gene at Home site.
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AGER Gene

protein-coding GIFtS: 66

Aliases &
Descriptions
for AGER

Summaries
for AGER

Genomic Location
for AGER

Proteins
for AGER

Protein Domains/
Families
for AGER

Gene Function
for AGER

Pathways & Interactions
for AGER

Drugs & Compounds
for AGER

Transcripts
for AGER

Expression
for AGER

Orthologs
for AGER

Paralogs
for AGER

SNPs/Variants
for AGER

Disorders & Mutations
for AGER

Medical News
for AGER

Publications
for AGER

Search for AGER

Genome Databases showing AGER

Other Databases showing AGER

Specialized Databases showing AGER

Licensable Technologies
for AGER

Services
for AGER

Gene Index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

AGER Gene

protein-coding GIFtS: 66

Aliases & Descriptionsfor AGER

Summariesfor AGER

Genomic Locationfor AGER

Proteinsfor AGER

Protein Domains/Familiesfor AGER

Gene Functionfor AGER

Pathways & Interactionsfor AGER

Drugs & Compoundsfor AGER

Transcriptsfor AGER

Expression for AGER

Orthologsfor AGER

Paralogsfor AGER

SNPs/Variantsfor AGER

Disorders & Mutationsfor AGER

Medical Newsfor AGER

Publicationsfor AGER

Search for AGER

Genome Databases showing AGER

Other Databases showing AGER

Specialized Databases showing AGER

Licensable Technologiesfor AGER

Servicesfor AGER

Gene Index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

Aliases &
Descriptions
for AGER

Summaries
for AGER

Genomic Location
for AGER

Proteins
for AGER

Protein Domains/
Families
for AGER

Gene Function
for AGER

Pathways & Interactions
for AGER

Drugs & Compounds
for AGER

Transcripts
for AGER

Expression
for AGER

Orthologs
for AGER

Paralogs
for AGER

SNPs/Variants
for AGER

Disorders & Mutations
for AGER

Medical News
for AGER

Publications
for AGER

Licensable Technologies
for AGER

Services
for AGER