AGER Gene
protein-coding GIFtS : 65 GCID: GC06 M032148
advanced glycosylation end product-specific receptor
Jump to Section...
Aliases
Databases
Disorders / Diseases
Domains / Families
Drugs / Compounds
Expression
Function
Genomic Views
Intellectual Property
Orthologs
Paralogs
Pathways / Interactions
Products
Proteins
Publications
Search Box
Summaries
Transcripts
Variants
TOP
BOTTOM
Aliasesfor AGER gene
(According to
1 HGNC ,
2 Entrez Gene ,
3 UniProtKB/Swiss-Prot ,
4 UniProtKB/TrEMBL , 5 OMIM , 6 GeneLoc ,
7 Ensembl ,
8 DME ,
9 miRBase ,
and/or 10 fRNAdb )About This Section Aliases Advanced Glycosylation End Product-Specific Receptor 1 2 RAGE1 2 3 5 RAGE Isoform NtRAGE-Delta2 RAGE Isoform SRAGE-Delta2 Receptor For Advanced Glycosylation End Products3
Export aliases for AGER gene to outside databases Previous GC identifers: GC06M032175 GC06M031920 GC06M032220 GC06M032256 GC06M031903
Jump to Section...
Aliases
Databases
Disorders / Diseases
Domains / Families
Drugs / Compounds
Expression
Function
Genomic Views
Intellectual Property
Orthologs
Paralogs
Pathways / Interactions
Products
Proteins
Publications
Search Box
Summaries
Transcripts
Variants
TOP
BOTTOM
Summariesfor AGER gene (According to Entrez Gene ,
Tocris Bioscience ,
Wikipedia's
Gene Wiki ,
PharmGKB ,UniProtKB/Swiss-Prot ,
and/or
UniProtKB/TrEMBL )
About This Section Entrez Gene summary for AGER : The advanced glycosylation end product (AGE) receptor encoded by this gene is a member of the immunoglobulin superfamily of cell surface receptors. It is a multiligand receptor, and besides AGE, interacts with other molecules implicated in homeostasis, development, and inflammation, and certain diseases, such as diabetes and Alzheimer's disease. Many alternatively spliced transcript variants encoding different isoforms, as well as non-protein-coding variants, have been described for this gene (PMID:18089847). (provided by RefSeq, May 2011) UniProtKB/Swiss-Prot: RAGE_HUMAN, Q15109 Function : Mediates interactions of advanced glycosylation end products (AGE). These are nonenzymatically glycosylatedproteins which accumulate in vascular tissue in aging and at an accelerated rate in diabetes. Acts as a mediator of both acute and chronic vascular inflammation in conditions such as atherosclerosis and in particular as a complication of diabetes. AGE/RAGE signaling plays an important role in regulating the production/expression of TNF-alpha, oxidative stress, and endothelial dysfunction in type 2 diabetes. Interaction with S100A12 on endothelium, mononuclear phagocytes, and lymphocytes triggers cellular activation, with generation of key proinflammatory mediators. Interaction with S100B after myocardial infarction may play a role in myocyte apoptosis by activating ERK1/2 and p53/TP53 signaling (By similarity). Receptor for amyloid beta peptide. Contributes to the translocation of amyloid-beta peptide (ABPP) across the cell membrane from the extracellular to the intracellular space in cortical neurons. ABPP-initiated RAGE signaling, especially stimulation of p38 mitogen-activated protein kinase (MAPK), has the capacity to drive a transport system delivering ABPP as a complex with RAGE to the intraneuronal space Gene Wiki entry for AGER (RAGE)
Jump to Section...
Aliases
Databases
Disorders / Diseases
Domains / Families
Drugs / Compounds
Expression
Function
Genomic Views
Intellectual Property
Orthologs
Paralogs
Pathways / Interactions
Products
Proteins
Publications
Search Box
Summaries
Transcripts
Variants
TOP
BOTTOM
Genomic Viewsfor AGER gene
(According to
GeneLoc and/or
HGNC , and/or
Entrez Gene (NCBI build 37) ,miRBase ,UCSC (hg19) and
Ensembl (release 69) ,
Regulatory elements and Epigenetics data according to
QIAGEN ,
SABiosciences , and/or
SwitchGear Genomics )About This Section RefSeq DNA sequence: NC_000006.11 NC_018917.1 NT_007592.15 NT_113891.2 NT_167244.1 NT_167246.1 NT_167247.1 NT_167248.1 NT_167249.1 Regulatory elements: SABiosciences Regulatory transcription factor binding sites in the AGER gene promoter:E2F-3a E2F-4 HEN1 E2F-5 E2F-1 STAT3 E2F-2 Other transcription factors Search SABiosciences Chromatin IP Primers for AGER Epigenetics: QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat AGER
Genomic Location: Genomic View : UCSC Golden Path with GeneCards custom track Entrez Gene cytogenetic band: 6p21.3 Ensembl cytogenetic band: 6p21.32 HGNC cytogenetic band: 6p21.3 AGER Gene in genomic location: bands according to Ensembl, locations according to
Entrez Gene Ensembl GeneLoc information about chromosome 6 GeneLoc Exon Structure
GeneLoc location for GC06M032148: view genomic region
(about GC identifiers )
Start: 32,148,745 bp from pter End:
32,152,101 bp from pter
Size: 3,357 bases Orientation:
minus strand
6 alternative locations : Chr 6-,ALT_REF_LOCI_5 32,139,996-32,143,273 Chr 6-,ALT_REF_LOCI_4 32,111,229-32,114,506 Chr 6-,ALT_REF_LOCI_6 32,106,368-32,145,227 Chr 6-,ALT_REF_LOCI_1 32,160,089-32,171,667 Chr 6-,ALT_REF_LOCI_2 32,097,222-32,139,688 Chr 6-,ALT_REF_LOCI_7 32,085,939-32,089,216
Jump to Section...
Aliases
Databases
Disorders / Diseases
Domains / Families
Drugs / Compounds
Expression
Function
Genomic Views
Intellectual Property
Orthologs
Paralogs
Pathways / Interactions
Products
Proteins
Publications
Search Box
Summaries
Transcripts
Variants
TOP
BOTTOM
Proteinsfor AGER gene
(According to
1 UniProtKB ,
HORDE ,
neXtProt ,
Ensembl ,
and/or Reactome ,
Modification sites according to 2 PhosphoSitePlus ,
Specific Peptides from DME ,
Protein expression images according to data from SPIRE MOPED and PaxDb ,
RefSeq according to NCBI ,
PDB rendering according to OCA and/or Proteopedia ,
Recombinant Proteins
from
EMD Millipore ,
R&D Systems ,
GenScript ,
Enzo Life Sciences ,
OriGene ,
Novus Biologicals ,
Sino Biological ,
ProSpec , and/or
Uscn ,
EMD Millipore ,
R&D Systems ,
OriGene ,
GenScript ,
Cell Signaling Technology ,
Enzo Life Sciences , and/or
Uscn ,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene ,
Antibodies by
EMD Millipore ,
R&D Systems ,
GenScript ,
Cell Signaling Technology ,
OriGene ,
Novus Biologicals ,
Thermo Fisher Scientific ,
Abcam , and/or
Uscn )
About This Section UniProtKB/Swiss-Prot: RAGE_HUMAN, Q15109 See
protein sequence )Recommended Name: Size : 404 amino acids; 42803 DaSubunit : Interacts with S100B, S100A1 and APP (By similarity). Interacts with S100A12Subcellular location : Isoform 1: Cell membrane; Single-pass type I membrane proteinSubcellular location : Isoform 2: Secreted6/11 PDB 3D structures from (see all 11 ):1PWI (3D) 2BJP (3D) 2E5E (3D) 2ENS (3D) 2L7U (3D) 2LE9 (3D) Secondary accessions : A2BFI7 A6NKF0 B0V176 Q15279 Q3L1R7 Q86SN1 Q9H2X7 Q9Y3R3Alternative splicing : 4 isoforms : Q15109-1 Q15109-2 Q15109-3 Q15109-4 Explore the universe of human proteins at neXtProt for AGER: NX_Q15109 Post-translational modifications:
View modification sites using PhosphoSitePlus 2 View neXtProt modification sites for NX_Q15109 AGER Protein expression data from MOPED and PaxDb : About this image REFSEQ proteins (9 alternative transcripts): NP_001127.1 NP_001193858.1 NP_001193861.1 NP_001193863.1 NP_001193865.1 NP_001193869.1 NP_001193883.1 NP_001193895.1 NP_751947.1 ENSEMBL proteins: ENSP00000364208 ENSP00000364195 ENSP00000364217 ENSP00000398466 ENSP00000364196 ENSP00000364211 ENSP00000364210 ENSP00000387887 ENSP00000364206 ENSP00000445389 Reactome Protein details: Q15109 Human Recombinant Protein Products for AGER: Gene Ontology (GO): 5/9 cellular component terms (GO ID links to tree view) (see all 9 ): About this table
About GeneDecksing AGER Antibody Products: Assay Products for AGER:
Jump to Section...
Aliases
Databases
Disorders / Diseases
Domains / Families
Drugs / Compounds
Expression
Function
Genomic Views
Intellectual Property
Orthologs
Paralogs
Pathways / Interactions
Products
Proteins
Publications
Search Box
Summaries
Transcripts
Variants
TOP
BOTTOM
Protein
Domains /for AGER gene (According to InterPro , ProtoNet ,
UniProtKB , and/or BLOCKS ,
Sets of similar genes according to GeneDecks )
About This Section About GeneDecksing 5/6 InterPro domains/families (see all 6 ):
Graphical View of Domain Structure for InterPro Entry Q15109 ProtoNet protein and cluster: Q15109
2 Blocks protein families : IPB003598 IPB013162 UniProtKB/Swiss-Prot: RAGE_HUMAN, Q15109 Similarity : Contains 2 Ig-like C2-type (immunoglobulin-like) domainsSimilarity : Contains 1 Ig-like V-type (immunoglobulin-like) domain
Jump to Section...
Aliases
Databases
Disorders / Diseases
Domains / Families
Drugs / Compounds
Expression
Function
Genomic Views
Intellectual Property
Orthologs
Paralogs
Pathways / Interactions
Products
Proteins
Publications
Search Box
Summaries
Transcripts
Variants
TOP
BOTTOM
Functionfor AGER gene
(According to 1 UniProtKB ,
Genatlas ,
LifeMap Discovery™ ,
IUBMB , and/or
2 DME ,
Human phenotypes from GenomeRNAi ,
Animal models from MGI Mar 06 2013,
inGenious Targeting Laboratory ,
SABiosciences ,
miRNA Gene Targets from miRTarBase ,
shRNA from
OriGene ,
Sirion Biotech ,
RNAi from
EMD Millipore ,
siRNAs from
OriGene ,
QIAGEN ,
microRNA from QIAGEN ,
Gene Editing from DNA2.0 ,
Sirion Biotech ,
Clones from EMD Millipore ,
OriGene ,
SwitchGear Genomics ,
GenScript ,
Sino Biological ,
DNA2.0 ,
and Vector BioLabs ,
Cell Lines from GenScript ,
LifeMap BioReagents ,
Sirion Biotech ,
In Situ Hybridization Assays from Advanced Cell Diagnostics ,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene .)
About This Section Molecular Function: UniProtKB/Swiss-Prot Summary: RAGE_HUMAN, Q15109 Function : Mediates interactions of advanced glycosylation end products (AGE). These are nonenzymatically glycosylatedproteins which accumulate in vascular tissue in aging and at an accelerated rate in diabetes. Acts as a mediator of both acute and chronic vascular inflammation in conditions such as atherosclerosis and in particular as a complication of diabetes. AGE/RAGE signaling plays an important role in regulating the production/expression of TNF-alpha, oxidative stress, and endothelial dysfunction in type 2 diabetes. Interaction with S100A12 on endothelium, mononuclear phagocytes, and lymphocytes triggers cellular activation, with generation of key proinflammatory mediators. Interaction with S100B after myocardial infarction may play a role in myocyte apoptosis by activating ERK1/2 and p53/TP53 signaling (By similarity). Receptor for amyloid beta peptide. Contributes to the translocation of amyloid-beta peptide (ABPP) across the cell membrane from the extracellular to the intracellular space in cortical neurons. ABPP-initiated RAGE signaling, especially stimulation of p38 mitogen-activated protein kinase (MAPK), has the capacity to drive a transport system delivering ABPP as a complex with RAGE to the intraneuronal space
Genatlas biochemistry entry for AGER receptor of advanced glycosylation end products of proteins,mediating amyloid beta peptide effect on neurons and microglia Gene Ontology (GO): 5 molecular function terms (GO ID links to tree view) : About this table
About GeneDecksing Phenotypes: 13 MGI mutant phenotypes (inferred from 4 alleles(MGI details for Ager) :About GeneDecksing Animal Models: Ager tm1.1Hyam for AGERClone Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human mouse rat see all 4 )human mouse rat see all 2 )OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling GenScript: all cDNA clones in your preferred vector (see all 2 ): AGER (NM_172197 ) Sino Biological Human cDNA Clone for AGER DNA2.0 Custom Codon Optimized Gene
Synthesis Service for AGER Vector BioLabs ready-to-use adenovirus/AAV for human , mouse , rat AGER
In Situ AssayAdvanced Cell Diagnostics RNAscope RNA in situ hybridization assays for AGER
Jump to Section...
Aliases
Databases
Disorders / Diseases
Domains / Families
Drugs / Compounds
Expression
Function
Genomic Views
Intellectual Property
Orthologs
Paralogs
Pathways / Interactions
Products
Proteins
Publications
Search Box
Summaries
Transcripts
Variants
TOP
BOTTOM
Pathways & Interactionsfor AGER gene
(Pathways according to
EMD Millipore ,
R&D Systems ,
Cell Signaling Technology ,
KEGG ,
PharmGKB ,
BioSystems ,
Reactome ,
Tocris Bioscience ,
GeneGo (Thomson Reuters) ,
QIAGEN ,
and/or UniProtKB ,
Sets of similar genes according to GeneDecks ,
Interaction Networks according to
SABiosciences ,
and/or STRING ,
Interactions according to 1 UniProtKB ,
2 MINT ,
3 I2D , and/or
4 STRING ,
with links to IntAct and
Ensembl ,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene) .
About This Section Unified GeneCards pathways - 5/6 super-pathways (see all 6 ) About this table See pathways by source Super-pathway contained gene-specific pathways 1 Immune System 2 NF-kappaB Signaling 3 AGE/RAGE pathway 4 A-beta Uptake & Degradation 5 amb2 Integrin signaling
Pathway sources See GeneCards unified pathways Show all pathways 1 1 2 3 About GeneDecksing Interactions: SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for AGER STRING Interaction
Network Preview (showing 5 interactants - click image to see 7)5/15 Interacting proteins for AGER (Q15109 1 , 2 , 3 ENSP00000364217 4 via UniProtKB, MINT, STRING , and/or I2D (see all 15 )About this table Gene Ontology (GO): 5/17 biological process terms (GO ID links to tree view) (see all 17 ): About this table
About GeneDecksing
Jump to Section...
Aliases
Databases
Disorders / Diseases
Domains / Families
Drugs / Compounds
Expression
Function
Genomic Views
Intellectual Property
Orthologs
Paralogs
Pathways / Interactions
Products
Proteins
Publications
Search Box
Summaries
Transcripts
Variants
TOP
BOTTOM
Drugs & Compoundsfor AGER gene (Chemical Compounds according to UniProtKB , Enzo Life Sciences ,
EMD Millipore , Tocris Bioscience
HMDB ,
BitterDB , and/or
Novoseek , and Drugs according to
DrugBank ,
Enzo Life Sciences , and/or
PharmGKB , with drugs/clinical trials/news
search links to CenterWatch )
About This Section About GeneDecksing Browse Tocris compounds for AGER 10/31 Novoseek chemical compound relationships for AGER gene (see all 31 ) About this table
Compound
-log (P-Val)
Hits
PubMed IDs for Articles with Shared Sentences (# sentences)
n(epsilon)-(carboxymethyl)lysine
79.1
22
19998499 (3), 10531386 (2), 10966490 (2), 15213320 (1) (see all 7 )
pentosidine
68.5
9
15213278 (1), 11576932 (1), 16315765 (1), 10966490 (1) (see all 5 )
3-deoxyglucosone
62.3
2
15213320 (1)
gw9662
59.7
2
17004092 (1), 18855759 (1)
telmisartan
44.1
13
17004092 (4), 18855759 (4), 16271939 (2), 17697525 (2)
glucose
42.3
30
19833897 (3), 19850013 (3), 15770917 (2), 17960513 (2) (see all 12 )
candesartan
41
5
15574998 (2), 16888237 (2), 17004092 (1)
oxygen
37.9
32
19833897 (2), 15553663 (2), 19190027 (2), 16712480 (1) (see all 21 )
olmesartan
31.5
5
17560613 (5), 16888237 (2)
vegf
29.7
24
17325184 (6), 17149374 (2), 18477569 (2), 15781285 (1) (see all 11 )
AGER / RAGE
Jump to Section...
Aliases
Databases
Disorders / Diseases
Domains / Families
Drugs / Compounds
Expression
Function
Genomic Views
Intellectual Property
Orthologs
Paralogs
Pathways / Interactions
Products
Proteins
Publications
Search Box
Summaries
Transcripts
Variants
TOP
BOTTOM
Transcriptsfor AGER gene (Secondary structures according to
fRNAdb ,Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank , Entrez Gene ,
DOTS (version 10), and/or
AceView ,
transcript ids from Ensembl
with links to UCSC , GeneLoc ,
alternative splicing isoforms according to ASD and/or
ECgene ,EMD Millipore ,
OriGene ,
QIAGEN ,
shRNA from
OriGene ,
Sirion Biotech ,
microRNA from QIAGEN ,
OriGene ,
SwitchGear Genomics ,
GenScript ,
DNA2.0 ,
Vector BioLabs ,
Primers from
OriGene ,
SABiosciences , and/or
QIAGEN
)About This Section REFSEQ mRNAs for AGER gene (9 alternative transcripts): NM_001136.4 NM_001206929.1 NM_001206932.1 NM_001206934.1 NM_001206936.1 NM_001206940.1 NM_001206954.1 NM_001206966.1 NM_172197.2 Unigene Cluster for AGER:
Advanced glycosylation end product-specific receptor Hs.534342 [show with all ESTs ] Unigene Representative Sequence: NR_038190 14 Ensembl transcripts including schematic representations, and UCSC links where relevant : ENST00000469940 ENST00000488669 ENST00000473619 ENST00000375067 ENST00000375055 (uc003oat.2 uc011dpo.2 uc021yvr.1 uc003oau.2 uc003oas.2 uc010jtv.2 )ENST00000484849 (uc021yvm.1 uc021yvn.1 uc021yvo.1 uc021yvp.1 uc021yvq.1 uc011dpn.2 uc011dpm.2 uc003oar.3 )ENST00000375076 (uc003oan.2 uc003oao.2 uc010jtw.2 uc003oap.2 uc003oam.2 uc003oal.2 uc003oaq.2 )ENST00000450110 ENST00000375056 ENST00000375070 (uc011dpp.2 uc011dpq.2 uc011dpr.2 uc011dps.2 )ENST00000375069 ENST00000438221 ENST00000375065 ENST00000538695 Clone OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human mouse rat see all 4 )human mouse rat see all 2 )OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling GenScript: all cDNA clones in your preferred vector (see all 2 ): AGER (NM_172197 ) DNA2.0 Custom Codon Optimized Gene
Synthesis Service for AGER Vector BioLabs ready-to-use adenovirus/AAV for human , mouse , rat AGER
Additional cDNA sequence: AB036432.1 AB061668.1 AB061669.1 AF536237.1 AJ133822.1 AK298100.1 AK313178.1 AY755619.1 AY755620.1 AY755621.1 AY755622.1 AY755623.1 AY755624.1 AY755627.1 AY755628.1 BC020669.1 DQ104252.1 DQ104254.1 EU117141.1 EU428811.1 EU428812.1 EU428813.1 EU428814.1 EU428815.1 EU428816.1 EU826618.1 HQ148133.1 M91211.1 NR_038190.1
11 DOTS entries : DT.100642746 DT.121378339
DT.121378379 DT.121378225 DT.121378333 DT.91637899 DT.95371256 DT.91722873 DT.91722860 DT.97832209 DT.101985408 24/307 AceView cDNA sequences (see all 307 ):
BC082261 CD251257 CA428962 BQ023810 BU899237 AW177610 BF476466 CD722009 BQ690225 AW177611 BU188403 AF537303 AB036432 BU622208 BU521990 BM726610 CD722431 BM702297 BQ024657 BM894006 BM714937 BC003111 AI057090 AI620218 GeneLoc Exon Structure
Jump to Section...
Aliases
Databases
Disorders / Diseases
Domains / Families
Drugs / Compounds
Expression
Function
Genomic Views
Intellectual Property
Orthologs
Paralogs
Pathways / Interactions
Products
Proteins
Publications
Search Box
Summaries
Transcripts
Variants
TOP
BOTTOM
Expression for AGER gene
(RNA expression data according to
H-InvDB ,
NONCODE ,
miRBase , and
RNAdb ,
Expression images according to data from
BioGPS ,
Illumina Human BodyMap , and
CGAP
SAGE ,
Sets of similar genes according to GeneDecks ,
in vivo and in vitro expression data from LifeMap Discovery™ ,
plus additional links to
Genevestigator , and/or
SOURCE , and/or
BioGPS , and/or
UniProtKB ,SABiosciences ,
Primers from
OriGene ,
SABiosciences , and/or
QIAGEN ,
In Situ Hybridization Assays from Advanced Cell Diagnostics )
About This Section AGER expression in normal human tissues (normalized intensities) See probesets specificity/sensitivity at GeneAnnot About this image BioGPS CGAP TAG: TGTGTCAGAGAbout this image AGER expression in embryonic tissues and stem cells About this table
Stem Cell Differentiation: 1 LifeMap Cell Name Category Mature brain microvascular endothelial cells (Derivation of blood-... )Expression: Experimental details:
In-situ hybridization
See AGER Protein Expression from SPIRE MOPED and PaxDB Genevestigator expression for AGER SOURCE GeneReport for Unigene cluster: Hs.534342 UniProtKB/Swiss-Prot: RAGE_HUMAN, Q15109 Tissue specificity : Endothelial cellsSABiosciences Expression via Pathway-Focused PCR Array including AGER : Primer OriGene genome-wide validated SYBR primer pairs in human mouse rat Browse OriGene validated miRNA SYBR primer pairs SABiosciences RT2 qPCR Primer Assay in human mouse rat QIAGEN QuantiTect SYBR Green Assays in human mouse rat QIAGEN QuantiFast Probe-based Assays in human mouse rat In Situ Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for AGER
Jump to Section...
Aliases
Databases
Disorders / Diseases
Domains / Families
Drugs / Compounds
Expression
Function
Genomic Views
Intellectual Property
Orthologs
Paralogs
Pathways / Interactions
Products
Proteins
Publications
Search Box
Summaries
Transcripts
Variants
TOP
BOTTOM
Orthologsfor AGER gene
(Orthologs according to
1,2 HomoloGene (2 older version, for species not in 1 newer version),
3 euGenes ,
4 SGD
,
5 MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase ,
and/or
6 Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam )
About This Section
ENSEMBL Gene Tree for AGER (if available)TreeFam Gene Tree for AGER (if available)
Jump to Section...
Aliases
Databases
Disorders / Diseases
Domains / Families
Drugs / Compounds
Expression
Function
Genomic Views
Intellectual Property
Orthologs
Paralogs
Pathways / Interactions
Products
Proteins
Publications
Search Box
Summaries
Transcripts
Variants
TOP
BOTTOM
Paralogsfor AGER gene (Paralogs according to
1 HomoloGene ,2 Ensembl , and 3 SIMAP , Pseudogenes according to 4 Pseudogene.org Build 68)About This Section Paralogs for AGER gene BCAM 2 MCAM 2 ALCAM 2 2 SIMAP similar genes for AGER using alignment to 39 protein entries: RAGE_HUMAN (see all proteins ):RAGE ALCAM About GeneDecksing
Jump to Section...
Aliases
Databases
Disorders / Diseases
Domains / Families
Drugs / Compounds
Expression
Function
Genomic Views
Intellectual Property
Orthologs
Paralogs
Pathways / Interactions
Products
Proteins
Publications
Search Box
Summaries
Transcripts
Variants
TOP
BOTTOM
Genomic Variantsfor AGER gene (SNPs/Variants according to the
1 NCBI SNP Database ,
2 Ensembl ,
3 PupaSUITE ,
UniProtKB , and
DNA2.0 ,
Linkage Disequilibrium by HapMap ,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants , Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB) , Blood group antigen gene mutations by BGMUT ,
Resequencing Primers from QIAGEN ,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences )
About This Section Genomic Data Transcription Related Data Allele Frequencies SNP ID Valid Clinical Chr 6 pos Sequence # AA Type More # Allele Pop Total More
HapMap Linkage Disequilibrium report for AGER (32148745 - 32152101 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions) Database of Genomic Variants (DGV): 1 variation for AGER 1 CNV 3602 Human Gene Mutation Database (HGMD) : AGER SABiosciences Cancer Mutation PCR Assays
QIAGEN SeqTarget long-range PCR primers in human mouse rat
Jump to Section...
Aliases
Databases
Disorders / Diseases
Domains / Families
Drugs / Compounds
Expression
Function
Genomic Views
Intellectual Property
Orthologs
Paralogs
Pathways / Interactions
Products
Proteins
Publications
Search Box
Summaries
Transcripts
Variants
TOP
BOTTOM
Disorders
/ Diseasesfor AGER gene
(in which this Gene is Involved, According to MalaCards ,
OMIM, UniProtKB ,
the University of Copenhagen DISEASES
database , Novoseek ,
Genatlas , GeneTests ,
GAD ,
HuGE Navigator ,
and/or TGDB .)
About This Section About GeneDecksing OMIM gene information: 600214
OMIM disorders : --20/121 (see all 121 ): About MalaCards limb-girdle muscular dystrophy alzheimer's disease ceroid lipofuscinosis neuronal ceroid-lipofuscinosis disseminated intravascular coagulation age related macular degeneration cor pulmonale non-small cell lung carcinoma aortic valve stenosis polycystic ovary syndrome diabetic angiopathy type 2 diabetes mellitus coronary heart disease myocardial infarction macular degeneration squamous cell carcinoma muscular dystrophy diabetes mellitus idiopathic pulmonary fibrosis insulin resistance 3 diseases from the University of Copenhagen DISEASES database for AGER :Diabetes mellitus Alzheimer's disease Atherosclerosis 10/61 Novoseek disease relationships for AGER gene (see all 61 ) About this table
Disease
-log (P-Val)
Hits
PubMed IDs for Articles with Shared Sentences (# sentences)
diabetic angiopathies
68.9
1
17462779 (1)
diabetic nephropathies
65.2
31
8559486 (4), 16936199 (3), 10966490 (3), 17667983 (2) (see all 13 )
hyperglycemia
64.4
18
11694852 (1), 20299674 (1), 20495289 (1), 14670831 (1) (see all 8 )
atherosclerosis
63.9
39
10421989 (2), 20372816 (2), 19217461 (2), 17097822 (2) (see all 26 )
microangiopathy diabetic
58.5
6
18855759 (2), 15823719 (1), 15224502 (1), 16146671 (1) (see all 5 )
diabetes mellitus
55.4
10
19636529 (1), 18331234 (1), 9044315 (1), 19591173 (1) (see all 6 )
diabetic retinopathy
54.1
16
18331234 (2), 16047941 (2), 17251488 (2), 16216433 (1) (see all 12 )
inflammation
53.4
45
19292913 (3), 17117586 (3), 20192808 (2), 19679874 (2) (see all 31 )
vascular diseases
47.9
27
19275767 (5), 7887450 (3), 16356122 (2), 9044300 (1) (see all 11 )
diabetic cardiomyopathy
47.4
2
19602045 (2)
Genetic Association Database (GAD): AGER Human Genome Epidemiology (HuGE) Navigator: AGER (37 documents) Export disorders for AGER gene to outside databases
Jump to Section...
Aliases
Databases
Disorders / Diseases
Domains / Families
Drugs / Compounds
Expression
Function
Genomic Views
Intellectual Property
Orthologs
Paralogs
Pathways / Interactions
Products
Proteins
Publications
Search Box
Summaries
Transcripts
Variants
TOP
BOTTOM
Publicationsfor AGER gene (in
PubMed .
Associations of this gene to articles via
1 Entrez Gene ,
2 UniProtKB/Swiss-Prot ,
3 HGNC ,
4 GAD ,
5 PharmGKB ,
6 HMDB ,
7 DrugBank ,
8 UniProtKB/TrEMBL ,
9 Novoseek , and/or
10 fRNAdb )
About This Section PubMed articles for AGER gene, integrated from 9 sources (see all 652 ):(articles sorted by number of sources associating them with AGER) Utopia : connect your pdf to the dynamic
Effects of novel polymorphisms in the RAGE gene on transcriptional regulation and their association with diabetic retinopathy. (PubMed id 11375354) 1 , 2 , 4(2001) Cloning and expression of a cell surface receptor for advanced glycosylation end products of proteins. (PubMed id 1378843) 1 , 2 , 9(1992) Novel splice variants of the receptor for advanced glycation end- products expressed in human vascular endothelial cells and pericytes, and their putative roles in diabetes-induced vascular injury. (PubMed id 12495433) 1 , 2 , 9(2003) Polymorphisms 1704G/T and 2184A/G in the RAGE gene are associated with antioxidant status. (PubMed id 11586486) 1 , 4, 9(2001) -429T/C and -374T/A polymorphisms of RAGE gene promoter are not associated with diabetic retinopathy in Chinese patients with type 2 diabetes. (PubMed id 12941744) 1 , 4, 9(2003) Association of Gly82Ser polymorphism in the RAGE gene with diabetic retinopathy in type II diabetic Asian Indian patients. (PubMed id 12477623) 1 , 4, 9(2002) Three genes in the human MHC class III region near the junction with the class II: gene for receptor of advanced glycosylation end products, PBX2 homeobox gene and a notch homolog, human counterpart of mouse mammary tumor gene int-3. (PubMed id 7835890) 1 , 2 , 9(1994) RAGE-dependent signaling in microglia contributes to neuroinflammation, A{beta} accumulation, and impaired learning/memory in a mouse model of Alzheimer's disease. (PubMed id 19906677) 1 , 2 (2009) Both Ca2+ and Zn2+ are essential for S100A12 protein oligomerization and function. (PubMed id 19386136) 1 , 2 (2009) Identification, classification, and expression of RAGE gene splice variants. (PubMed id 18089847) 1 , 2 (2008)
Jump to Section...
Aliases
Databases
Disorders / Diseases
Domains / Families
Drugs / Compounds
Expression
Function
Genomic Views
Intellectual Property
Orthologs
Paralogs
Pathways / Interactions
Products
Proteins
Publications
Search Box
Summaries
Transcripts
Variants
TOP
BOTTOM
External Searches for AGER gene
(in PubMed ,
OMIM , and NCBI Bookshelf ) About This Section
Jump to Section...
Aliases
Databases
Disorders / Diseases
Domains / Families
Drugs / Compounds
Expression
Function
Genomic Views
Intellectual Property
Orthologs
Paralogs
Pathways / Interactions
Products
Proteins
Publications
Search Box
Summaries
Transcripts
Variants
TOP
BOTTOM
Genome Databases showing AGER gene
(According to
Entrez Gene ,
HGNC ,
AceView ,
euGenes ,
Ensembl ,
miRBase ,
ECgene ,
Kegg ,
and/or
H-InvDB )
About This Section
Jump to Section...
Aliases
Databases
Disorders / Diseases
Domains / Families
Drugs / Compounds
Expression
Function
Genomic Views
Intellectual Property
Orthologs
Paralogs
Pathways / Interactions
Products
Proteins
Publications
Search Box
Summaries
Transcripts
Variants
TOP
BOTTOM
Other Databases showing AGER gene
(According to HUGE )
About This Section --
Jump to Section...
Aliases
Databases
Disorders / Diseases
Domains / Families
Drugs / Compounds
Expression
Function
Genomic Views
Intellectual Property
Orthologs
Paralogs
Pathways / Interactions
Products
Proteins
Publications
Search Box
Summaries
Transcripts
Variants
TOP
BOTTOM
Specialized Databases showing AGER gene (According to PharmGKB ,
ATLAS , HORDE , IMGT , LEIDEN , UniProtKB/Swiss-Prot , and/or UniProtKB/TrEMBL ,Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot )About This Section
Jump to Section...
Aliases
Databases
Disorders / Diseases
Domains / Families
Drugs / Compounds
Expression
Function
Genomic Views
Intellectual Property
Orthologs
Paralogs
Pathways / Interactions
Products
Proteins
Publications
Search Box
Summaries
Transcripts
Variants
TOP
BOTTOM
About This Section Patent Information for AGER gene: AGER GeneCards and IP: Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
Jump to Section...
Aliases
Databases
Disorders / Diseases
Domains / Families
Drugs / Compounds
Expression
Function
Genomic Views
Intellectual Property
Orthologs
Paralogs
Pathways / Interactions
Products
Proteins
Publications
Search Box
Summaries
Transcripts
Variants
TOP
BOTTOM
Productsfor AGER gene (Antibodies, recombinant proteins, and assays from EMD Millipore , R&D Systems , OriGene , QIAGEN , GenScript , Cell Signaling Technology , SABiosciences , Novus Biologicals , Sino Biological , Enzo Life Sciences , Abcam , ProSpec , Uscn , Thermo Fisher Scientific , Gene Editing from DNA2.0 and Sirion Biotech , Clones from EMD Millipore , OriGene , GenScript , Sino Biological , DNA2.0 , SwitchGear Genomics , Vector BioLabs , Cell lines from GenScript , LifeMap BioReagents , and Sirion Biotech , PCR Arrays from SABiosciences , Drugs and/or compounds from EMD Millipore , Tocris Bioscience , and/or
Enzo Life Sciences , In Situ Hybridization Assays from Advanced Cell Diagnostics , Animal models from inGenious Targeting Laboratory )About This Section
Browse OriGene Antibodies OriGene shRNA RFP for AGER OriGene 29mer shRNA kits in GFP-retroviral vector in human mouse rat OriGene genome-wide validated SYBR primer pairs in human mouse rat OriGene Protein Over-expression Lysate for AGER Browse OriGene Fluorogenic Cell Assay Kits OriGene siRNA for AGER Browse 3'-UTR reporter clones for miRNA target validation OriGene untagged cDNA clones in CMV expression vector in human mouse rat OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human mouse rat Browse OriGene GFP tagged cDNA clones in CMV expression vector Browse OriGene MicroRNA Expression Plasmids Browse OriGene basic RS shRNAs Browse OriGene validated miRNA SYBR primer pairs Browse OriGene full length recombinant human proteins expressed in human HEK293 cells OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling OriGene Custom Antibody Services for AGER OriGene Custom Protein Services for AGER OriGene Custom Immunoassay Development
QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat AGER QIAGEN SeqTarget long-range PCR primers in human mouse rat QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat AGER QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human mouse rat QIAGEN QuantiFast Probe-based Assays in human mouse rat QIAGEN QuantiTect SYBR Green Assays in human mouse rat
Antibodies & Assays for AGER (RAGE)
Search Tocris compounds for AGER
AGER Proteins, Antibodies, CLIAs, and ELISAs
Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for AGER
ThermoFisher Antibody for AGER
Vector BioLabs ready-to-use adenovirus/AAV for human , mouse , rat AGER
Jump to Section...
Aliases for AGER
Databases for AGER
Disorders / Diseases for AGER
Domains / Families for AGER
Drugs / Compounds for AGER
Expression for AGER
Function for AGER
Genomic Views for AGER
Intellectual Property for AGER
Orthologs for AGER
Paralogs for AGER
Pathways / Interactions for AGER
Products for AGER
Proteins for AGER
Publications for AGER
Search Box for AGER
Summaries for AGER
Transcripts for AGER
Variants for AGER
TOP
BOTTOM
and Proteopedia 
for AGER (
Browse Tocris compounds for 
Expression by the Database of Embryonic development, Stem cell research, and
Regenerative medicine 
Negative
Selective marker
Microarrays
In-situ hybridization
