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AGER Gene

protein-coding   GIFtS: 65
GCID: GC06M032148

Advanced Glycosylation End Product-Specific Receptor

  See AGER-related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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This gene clusters with an RNA gene
Subcategory (RNA class): lncRNA

Quality score for the ORGUL clustered with this gene is 3

Aliases
Advanced Glycosylation End Product-Specific Receptor1 2
RAGE2 3 5
RAGE Isoform NtRAGE-Delta2
RAGE Isoform SRAGE-Delta2
Receptor For Advanced Glycation End-Products Variant 202
Receptor For Advanced Glycosylation End Products3

External Ids:    HGNC: 3201   Entrez Gene: 1772   Ensembl: ENSG000002043057   OMIM: 6002145   UniProtKB: Q151093   
ORGUL members:         

Export aliases for AGER gene to outside databases

Previous GC identifers: GC06M032175 GC06M031920 GC06M032220 GC06M032256 GC06M031903


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for AGER Gene:
The advanced glycosylation end product (AGE) receptor encoded by this gene is a member of the immunoglobulin
superfamily of cell surface receptors. It is a multiligand receptor, and besides AGE, interacts with other
molecules implicated in homeostasis, development, and inflammation, and certain diseases, such as diabetes and
Alzheimer's disease. Many alternatively spliced transcript variants encoding different isoforms, as well as
non-protein-coding variants, have been described for this gene (PMID:18089847). (provided by RefSeq, May 2011)

GeneCards Summary for AGER Gene:
AGER (advanced glycosylation end product-specific receptor) is a protein-coding gene. Diseases associated with AGER include diabetic angiopathy, and noma. GO annotations related to this gene include S100 protein binding and receptor activity.

UniProtKB/Swiss-Prot: RAGE_HUMAN, Q15109
Function: Mediates interactions of advanced glycosylation end products (AGE). These are nonenzymatically
glycosylated proteins which accumulate in vascular tissue in aging and at an accelerated rate in diabetes. Acts
as a mediator of both acute and chronic vascular inflammation in conditions such as atherosclerosis and in
particular as a complication of diabetes. AGE/RAGE signaling plays an important role in regulating the
production/expression of TNF-alpha, oxidative stress, and endothelial dysfunction in type 2 diabetes. Interaction
with S100A12 on endothelium, mononuclear phagocytes, and lymphocytes triggers cellular activation, with
generation of key proinflammatory mediators. Interaction with S100B after myocardial infarction may play a role
in myocyte apoptosis by activating ERK1/2 and p53/TP53 signaling (By similarity). Receptor for amyloid beta
peptide. Contributes to the translocation of amyloid-beta peptide (ABPP) across the cell membrane from the
extracellular to the intracellular space in cortical neurons. ABPP-initiated RAGE signaling, especially
stimulation of p38 mitogen-activated protein kinase (MAPK), has the capacity to drive a transport system
delivering ABPP as a complex with RAGE to the intraneuronal space. Can also bind oligonucleotides

Gene Wiki entry for AGER (RAGE) Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000006.11  NC_018917.2  NT_007592.16  NT_113891.3  NT_167244.2  NT_167246.2  NT_167247.2  NT_167248.2  
NT_167249.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the AGER gene promoter:
         E2F-3a   E2F-4   HEN1   E2F-5   E2F-1   STAT3   E2F-2   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidAGER promoter sequence
   Search Chromatin IP Primers for AGER

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat AGER


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 6p21.3   Ensembl cytogenetic band:  6p21.32   HGNC cytogenetic band: 6p21.3

AGER Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
AGER gene location

GeneLoc information about chromosome 6         GeneLoc Exon Structure

GeneLoc location for GC06M032148:  view genomic region     (about GC identifiers)

Start:
32,148,745 bp from pter      End:
32,152,101 bp from pter
Size:
3,357 bases      Orientation:
minus strand

6 alternative locations:
Chr6-,NT_167249 3,496,473-3,499,827      Chr6-,NT_167247 3,528,572-3,531,926      Chr6-,NT_113891.2 3,619,426-3,622,780     
Chr6-,NT_167246 3,491,569-3,494,923      Chr6-,NT_167244 3,463,486-3,466,840      Chr6-,NT_167248 3,409,765-3,413,119     

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., eBioscience, and/or antibodies-online,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., eBioscience, and/or antibodies-online, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, antibodies-online, and/or others.)
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UniProtKB/Swiss-Prot: RAGE_HUMAN, Q15109 (See protein sequence)
Recommended Name: Advanced glycosylation end product-specific receptor precursor  
Size: 404 amino acids; 42803 Da
Subunit: Interacts with S100A1 and APP (By similarity). Interacts with S100B, S100A12 and S100A14. Constitutive
homodimer; disulfide-linked
Selected PDB 3D structures from and Proteopedia for AGER (see all 13):
1PWI (3D)        2BJP (3D)        2E5E (3D)        2ENS (3D)        2L7U (3D)        2LE9 (3D)    
Secondary accessions: A2BFI7 A6NKF0 A7Y2U9 B0V176 Q15279 Q3L1R4 Q3L1R5 Q3L1R6 Q3L1R7 Q3L1R8
Q3L1S0 Q86SN1 Q9H2X7 Q9Y3R3
Alternative splicing: 9 isoforms:  Q15109-1   Q15109-2   Q15109-3   Q15109-4   Q15109-5   Q15109-6   Q15109-7   Q15109-8   
Q15109-9   

Explore the universe of human proteins at neXtProt for AGER: NX_Q15109

Explore proteomics data for AGER at MOPED

Post-translational modifications: 

  • Glycosylation2 at Asn25, Asn81
  • Modification sites at PhosphoSitePlus

  • See AGER Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (9 alternative transcripts): 
    NP_001127.1  NP_001193858.1  NP_001193861.1  NP_001193863.1  NP_001193865.1  NP_001193869.1  NP_001193883.1  NP_001193895.1  
    NP_751947.1  

    ENSEMBL proteins: 
     ENSP00000364208   ENSP00000364195   ENSP00000364217   ENSP00000398466   ENSP00000364196  
     ENSP00000364211   ENSP00000364210   ENSP00000387887   ENSP00000364206   ENSP00000445389  
    Reactome Protein details: Q15109

    AGER Human Recombinant Protein Products:

    Browse Purified and Recombinant Proteins at EMD Millipore
    R&D Systems Recombinant & Natural Proteins for AGER (RAGE)
    Browse recombinant and purified proteins available from Enzo Life Sciences
    OriGene Purified Protein for AGER
    OriGene Protein Over-expression Lysate for AGER
    OriGene Custom MassSpec
    OriGene Custom Protein Services for AGER
    GenScript Custom Purified and Recombinant Proteins Services for AGER
    Novus Biologicals AGER Proteins
    Novus Biologicals AGER Lysates
    Sino Biological Recombinant Protein for AGER
    Sino Biological Cell Lysate for AGER
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for AGER

     
    Search eBioscience for Proteins for AGER 

     
    antibodies-online proteins for AGER (37 products) 

     
    antibodies-online peptides for AGER

    AGER Antibody Products:

    EMD Millipore Mono- and Polyclonal Antibodies for the study of AGER
    R&D Systems Antibodies for AGER (RAGE)
    Cell Signaling Technology (CST) Antibodies for AGER  (RAGE)
    OriGene Antibodies for AGER
    OriGene Custom Antibody Services for AGER
    Novus Biologicals AGER Antibodies
    Search for Antibodies for AGER at Abcam
    Cloud-Clone Corp. Antibodies for AGER
    ThermoFisher Antibody for AGER
    LSBio Antibodies in human, mouse, rat for AGER
    antibodies-online antibodies for AGER (206 products) 

    AGER Assay Products:

    Browse Kits and Assays available from EMD Millipore
    OriGene Custom Assay Services for AGER
    R&D Systems ELISAs for AGER (RAGE)         (see all)
    GenScript Custom Assay Services for AGER
    Browse Enzo Life Sciences for kits & assays
    Cloud-Clone Corp. ELISAs for AGER
    Cloud-Clone Corp. CLIAs for AGER
    Search eBioscience for ELISAs for AGER 
    antibodies-online kits for AGER (41 products) 


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    C2SET: Immunoglobulin superfamily / C2-set domain containing
    IGD: Immunoglobulin superfamily / Immunoglobulin-like domain containing

    Selected InterPro protein domains (see all 6):
     IPR003598 Ig_sub2
     IPR013162 CD80_C2-set
     IPR013783 Ig-like_fold
     IPR007110 Ig-like_dom
     IPR003006 Ig/MHC_CS

    Graphical View of Domain Structure for InterPro Entry Q15109

    ProtoNet protein and cluster: Q15109

    2 Blocks protein domains:
    IPB003598 Immunoglobulin C-2 type
    IPB013162 CD80-like C2-set immunoglobulin


    UniProtKB/Swiss-Prot: RAGE_HUMAN, Q15109
    Similarity: Contains 2 Ig-like C2-type (immunoglobulin-like) domains
    Similarity: Contains 1 Ig-like V-type (immunoglobulin-like) domain


    Find genes that share domains with AGER           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: RAGE_HUMAN, Q15109
    Function: Mediates interactions of advanced glycosylation end products (AGE). These are nonenzymatically
    glycosylated proteins which accumulate in vascular tissue in aging and at an accelerated rate in diabetes. Acts
    as a mediator of both acute and chronic vascular inflammation in conditions such as atherosclerosis and in
    particular as a complication of diabetes. AGE/RAGE signaling plays an important role in regulating the
    production/expression of TNF-alpha, oxidative stress, and endothelial dysfunction in type 2 diabetes. Interaction
    with S100A12 on endothelium, mononuclear phagocytes, and lymphocytes triggers cellular activation, with
    generation of key proinflammatory mediators. Interaction with S100B after myocardial infarction may play a role
    in myocyte apoptosis by activating ERK1/2 and p53/TP53 signaling (By similarity). Receptor for amyloid beta
    peptide. Contributes to the translocation of amyloid-beta peptide (ABPP) across the cell membrane from the
    extracellular to the intracellular space in cortical neurons. ABPP-initiated RAGE signaling, especially
    stimulation of p38 mitogen-activated protein kinase (MAPK), has the capacity to drive a transport system
    delivering ABPP as a complex with RAGE to the intraneuronal space. Can also bind oligonucleotides

         Genatlas biochemistry entry for AGER:
    receptor of advanced glycosylation end products of proteins,mediating amyloid beta peptide effect on neurons and
    microglia

         Gene Ontology (GO): 5 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0004872receptor activity TAS8751438
    GO:0004888transmembrane signaling receptor activity TAS1378843
    GO:0005515protein binding IPI16061848
    GO:0042802identical protein binding IPI--
    GO:0044548S100 protein binding IPI15033494
         
    Find genes that share ontologies with AGER           About GenesLikeMe


    Phenotypes:
         13 MGI mutant phenotypes (inferred from 4 alleles(MGI details for Ager):
     behavior/neurological  cardiovascular system  cellular  growth/size/body  hematopoietic system 
     homeostasis/metabolism  immune system  integument  muscle  no phenotypic analysis 
     normal  renal/urinary system  skeleton 

    Find genes that share phenotypes with AGER           About GenesLikeMe

    Animal Models:
         MGI mouse knock-out Agertm1.1Hyam for AGER

       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for AGER
       inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for AGER

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for AGER
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for AGER

    miRNA
    Products:
        
    miRTarBase miRNAs that target AGER:
    hsa-mir-195-5p (MIRT044860), hsa-mir-16-5p (MIRT051103), hsa-mir-10a-5p (MIRT047532)

    Block miRNA regulation of human, mouse, rat AGER using miScript Target Protectors
    2 qRT-PCR Assays for microRNAs that regulate AGER:
    hsa-miR-3934 hsa-miR-592
    SwitchGear 3'UTR luciferase reporter plasmidAGER 3' UTR sequence
    Inhib. RNA
    Products:
        
    OriGene RNAi products in human, mouse, rat for AGER
    Predesigned siRNA for gene silencing in human, mouse, rat AGER

    Gene Editing
    Products:
    DNA2.0 Custom Protein Engineering Service for AGER

    Clone
    Products:
         
    OriGene clones in human, mouse for AGER (see all 10)
    OriGene ORF clones in mouse, rat for AGER
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector (see all 2): AGER (NM_172197)
    Sino Biological Human cDNA Clone for AGER
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for AGER
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat AGER

    Cell Line
    Products:
         
    GenScript Custom overexpressing Cell Line Services for AGER
    Browse ESI BIO Cell Lines and PureStem Progenitors for AGER 
    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for AGER


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    RAGE_HUMAN, Q15109: Isoform 1: Cell membrane; Single-pass type I membrane protein
    RAGE_HUMAN, Q15109: Isoform 2: Secreted
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    extracellular5
    plasma membrane5
    cytoskeleton2
    nucleus2
    endoplasmic reticulum1

    Gene Ontology (GO): 4 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005576extracellular region IEA--
    GO:0005886plasma membrane TAS--
    GO:0005887integral component of plasma membrane TAS1378843
    GO:0016020membrane ----

    Find genes that share ontologies with AGER           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for AGER About   (see all 8)  
    See pathways by source

    SuperPathContained pathways About
    1Toll Like Receptor 7/8 (TLR7/8) Cascade
    Toll Like Receptor 9 (TLR9) Cascade0.93
    MyD88 dependent cascade initiated on endosome0.69
    TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation0.93
    MyD88-independent cascade0.69
    Toll Like Receptor 7/8 (TLR7/8) Cascade0.69
    Toll Like Receptor 3 (TLR3) Cascade0.69
    2Cytosolic sensors of pathogen-associated DNA
    RIP-mediated NFkB activation via ZBP10.81
    TAK1 activates NFkB by phosphorylation and activation of IKKs complex0.52
    ZBP1(DAI) mediated induction of type I IFNs0.81
    Cytosolic sensors of pathogen-associated DNA0.38
    TRAF6 mediated NF-kB activation0.55
    DEx/H-box helicases activate type I IFN and inflammatory cytokines production0.00
    3RIG-I/MDA5 mediated induction of IFN-alpha/beta pathways
    RIG-I/MDA5 mediated induction of IFN-alpha/beta pathways0.47
    4NF-kappaB Signaling
    NF-kappaB Signaling
    5amb2 Integrin signaling
    amb2 Integrin signaling


    Find genes that share SuperPaths with AGER           About GenesLikeMe

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    1 R&D Systems Pathway for AGER
        A-beta Uptake & Degradation

    1 Downloadable PowerPoint Slide of GeneGlobe Pathway Central Maps for AGER
        HMGB1 Pathway

    1 Cell Signaling Technology (CST) Pathway for AGER
        NF-kappaB Signaling

    2 BioSystems Pathways for AGER
        AGE/RAGE pathway
    amb2 Integrin signaling


    5 Reactome Pathways for AGER
        DEx/H-box helicases activate type I IFN and inflammatory cytokines production
    Advanced glycosylation endproduct receptor signaling
    RIP-mediated NFkB activation via ZBP1
    TAK1 activates NFkB by phosphorylation and activation of IKKs complex
    TRAF6 mediated NF-kB activation


        Pathway & Disease-focused RT2 Profiler PCR Array including AGER: 
              Lung Cancer in human mouse rat

    Interactions:

        GeneGlobe Interaction Network for AGER

    STRING Interaction Network Preview (showing 5 interactants - click image to see 7)

    Selected Interacting proteins for AGER (Q151091, 2, 3 ENSP000003642174) via UniProtKB, MINT, STRING, and/or I2D (see all 16)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    RHOAP615861, 2, 3EBI-1646426,EBI-446668 MINT-7301186 MINT-7301204 I2D: score=1 
    GRB2P629931, 3EBI-1646426,EBI-401755 I2D: score=2 
    NCK1P163331, 3EBI-1646426,EBI-389883 I2D: score=2 
    S100BP042711, 2, 3, ENSP000002917004EBI-1646426,EBI-458391 MINT-5224202 MINT-5224259 MINT-5224222 MINT-5224235 I2D: score=2 STRING: ENSP00000291700
    TTRP027661, 2, 3, ENSP000002370144EBI-1646426,EBI-711909 MINT-2635425 MINT-2635447 I2D: score=2 STRING: ENSP00000237014
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 7):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006954inflammatory response IEA--
    GO:0007166cell surface receptor signaling pathway TAS10835680
    GO:0009611response to wounding TAS10399917
    GO:0031175neuron projection development IGI10391939
    GO:0045087innate immune response TAS--

    Find genes that share ontologies with AGER           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for AGER (RAGE)

    Selected Novoseek inferred chemical compound relationships for AGER gene (see all 31)    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    n(epsilon)-(carboxymethyl)lysine 79.1 22 19998499 (3), 10531386 (2), 10966490 (2), 15213320 (1) (see all 7)
    pentosidine 68.5 9 15213278 (1), 11576932 (1), 16315765 (1), 10966490 (1) (see all 5)
    3-deoxyglucosone 62.3 2 15213320 (1)
    gw9662 59.7 2 17004092 (1), 18855759 (1)
    telmisartan 44.1 13 17004092 (4), 18855759 (4), 16271939 (2), 17697525 (2)
    glucose 42.3 30 19833897 (3), 19850013 (3), 15770917 (2), 17960513 (2) (see all 12)
    candesartan 41 5 15574998 (2), 16888237 (2), 17004092 (1)
    oxygen 37.9 32 19833897 (2), 15553663 (2), 19190027 (2), 16712480 (1) (see all 21)
    olmesartan 31.5 5 17560613 (5), 16888237 (2)
    vegf 29.7 24 17325184 (6), 17149374 (2), 18477569 (2), 15781285 (1) (see all 11)



    Find genes that share compounds with AGER           About GenesLikeMe



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for AGER gene (9 alternative transcripts): 
    NM_001136.4  NM_001206929.1  NM_001206932.1  NM_001206934.1  NM_001206936.1  NM_001206940.1  NM_001206954.1  NM_001206966.1  
    NM_172197.2  

    Unigene Cluster for AGER:

    Advanced glycosylation end product-specific receptor
    Hs.534342  [show with all ESTs]
    Unigene Representative Sequence: NR_038190
    14 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000469940 ENST00000488669 ENST00000473619 ENST00000375067 ENST00000375055(uc003oat.2 uc011dpo.2 uc021yvr.1 uc003oau.2 uc003oas.2 uc010jtv.2)
    ENST00000484849(uc021yvm.1 uc021yvn.1 uc021yvo.1 uc021yvp.1 uc021yvq.1 uc011dpn.2 uc011dpm.2 uc003oar.3)
    ENST00000375076(uc003oan.2 uc003oao.2 uc010jtw.2 uc003oap.2 uc003oam.2 uc003oal.2 uc003oaq.2)
    ENST00000450110 ENST00000375056 ENST00000375070(uc011dpp.2 uc011dpq.2 uc011dpr.2 uc011dps.2)
    ENST00000375069 ENST00000438221 ENST00000375065 ENST00000538695
    miRNA
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    2 qRT-PCR Assays for microRNAs that regulate AGER:
    hsa-miR-3934 hsa-miR-592
    SwitchGear 3'UTR luciferase reporter plasmidAGER 3' UTR sequence
    Inhib. RNA
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    OriGene RNAi products in human, mouse, rat for AGER
    Predesigned siRNA for gene silencing in human, mouse, rat AGER
    Clone
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    OriGene clones in human, mouse for AGER (see all 10)
    OriGene ORF clones in mouse, rat for AGER
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector (see all 2): AGER (NM_172197)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for AGER
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat AGER
    Primer
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    OriGene qPCR primer pairs and template standards for AGER
    OriGene qSTAR qPCR primer pairs in human, mouse for AGER
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat AGER
      QuantiTect SYBR Green Assays in human, mouse, rat AGER
      QuantiFast Probe-based Assays in human, mouse, rat AGER

    Additional mRNA sequence: 

    AB036432.1 AB061668.1 AB061669.1 AF536237.1 AJ133822.1 AK298100.1 AK313178.1 AY755619.1 
    AY755620.1 AY755621.1 AY755622.1 AY755623.1 AY755624.1 AY755627.1 AY755628.1 BC020669.1 
    DQ104252.1 DQ104254.1 EU117141.1 EU428811.1 EU428812.1 EU428813.1 EU428814.1 EU428815.1 
    EU428816.1 EU826618.1 HQ148133.1 M91211.1 NR_038190.1 

    11 DOTS entries:

    DT.100642746  DT.121378339  DT.121378379  DT.121378225  DT.121378333  DT.91637899  DT.95371256  DT.91722873 
    DT.91722860  DT.97832209  DT.101985408 

    Selected AceView cDNA sequences (see all 307):

    CD722431 AW177610 NM_002586 BU899237 AW177611 AI057090 BU188403 BM726610 
    BQ690225 CD722009 CD251257 AW375386 BM894006 AI620218 AF537303 BM702297 
    BX092491 CR601493 AB036432 BM967099 BM714937 BM547314 AW150393 CD364731 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

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    AGER expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: TGTGTCAGAG
    AGER Expression
    About this image


    AGER expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 4) fully expand
     
     Gut Tube (Gastrointestinal Tract)
             Foregut
     
     Endothelium (Cardiovascular System)
             Mature brain microvascular endothelial cells
     
     Brain (Nervous System)
             Mature brain microvascular endothelial cells
     
     Lung (Respiratory System)
    AGER Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    AGER Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.534342

    UniProtKB/Swiss-Prot: RAGE_HUMAN, Q15109
    Tissue specificity: Endothelial cells

        Pathway & Disease-focused RT2 Profiler PCR Array including AGER: 
              Lung Cancer in human mouse rat

    Primer
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for AGER

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of human and mouse.

    Orthologs for AGER gene from Selected species (see all 7)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Ager1 , 5 advanced glycosylation end product-specific receptor1, 5 81.09(n)1
    78.61(a)1
      17 (18.18 cM)5
    115961  NM_007425.31  NP_031451.21 
     345978625 


    ENSEMBL Gene Tree for AGER (if available)
    TreeFam Gene Tree for AGER (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for AGER gene
    2 SIMAP similar genes for AGER using alignment to 25 protein entries:     RAGE_HUMAN (see all proteins):
    RAGE    ALCAM

    Find genes that share paralogs with AGER           About GenesLikeMe



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
    About This Section

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    Selected SNPs for AGER (see all 190)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 6 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1883481541,2
    --32065773(+) ATAGAC/TGGGAG 10 -- ds5001 int10--------
    rs1811764441,2
    --32065775(+) AGATGC/GGAGAG 10 -- ds5001 int10--------
    rs83651,2
    C,F,A,H--32065901(-) AAGATC/GAAATC 10 -- ds5001 int122Minor allele frequency- G:0.12MN NS EA NA WA 2942
    rs563474391,2
    C--32066117(+) GCATCC/TTCTCC 10 -- ds5001 int10--------
    rs560874201,2
    C--32066126(+) CCCCAA/GCTTGA 10 -- ds5001 int10--------
    rs412704641,2
    C,F--32066222(+) TCATAC/TACACA 10 -- ds5001 int12Minor allele frequency- T:0.06WA NA 238
    rs563135011,2
    C--32066227(+) CACACA/GCACAG 10 -- ds5001 int10--------
    rs1464341201,2
    --32066334(+) GATTAC/TACAGG 10 -- ut31 nc-transcript-variant0--------
    rs2015752551,2
    C--32066408(+) TCTGT-/TGGTGGG 10 -- ut31 nc-transcript-variant0--------
    rs1403668011,2
    C--32066425(+) AAGGCC/TCTCCA 13 E G mis1 ut31 int11Minor allele frequency- T:0.00NA 4552

    HapMap Linkage Disequilibrium report for AGER (32148745 - 32152101 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 3 variations for AGER:    About this table    
    Variant IDTypeSubtypePubMed ID
    nsv830629CNV Loss17160897
    nsv462877CNV Loss19166990
    dgv1929e1CNV Complex17122850

    Human Gene Mutation Database (HGMD): AGER
    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing AGER
    DNA2.0 Custom Variant and Variant Library Synthesis for AGER

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 600214    OMIM disorders: --

    8 diseases for AGER:    
    About MalaCards
    diabetic angiopathy    noma    obstructive lung disease    leukostasis
    diabetic nephropathy    vascular disease    coronary artery disease    type 2 diabetes mellitus

    3 diseases from the University of Copenhagen DISEASES database for AGER:
    Diabetes mellitus     Alzheimer's disease     Atherosclerosis

    Find genes that share disorders with AGER           About GenesLikeMe

    Selected Novoseek inferred disease relationships for AGER gene (see all 61)    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    diabetic angiopathies 68.9 1 17462779 (1)
    diabetic nephropathies 65.2 31 8559486 (4), 16936199 (3), 10966490 (3), 17667983 (2) (see all 13)
    hyperglycemia 64.4 18 11694852 (1), 20299674 (1), 20495289 (1), 14670831 (1) (see all 8)
    atherosclerosis 63.9 39 10421989 (2), 20372816 (2), 19217461 (2), 17097822 (2) (see all 26)
    microangiopathy diabetic 58.5 6 18855759 (2), 15823719 (1), 15224502 (1), 16146671 (1) (see all 5)
    diabetes mellitus 55.4 10 19636529 (1), 18331234 (1), 9044315 (1), 19591173 (1) (see all 6)
    diabetic retinopathy 54.1 16 18331234 (2), 16047941 (2), 17251488 (2), 16216433 (1) (see all 12)
    inflammation 53.4 45 19292913 (3), 17117586 (3), 20192808 (2), 19679874 (2) (see all 31)
    vascular diseases 47.9 27 19275767 (5), 7887450 (3), 16356122 (2), 9044300 (1) (see all 11)
    diabetic cardiomyopathy 47.4 2 19602045 (2)

    Genetic Association Database (GAD): AGER
    Human Genome Epidemiology (HuGE) Navigator: AGER (37 documents)

    Export disorders for AGER gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

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    PubMed articles for AGER gene, integrated from 10 sources (see all 715):
    (articles sorted by number of sources associating them with AGER)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Effects of novel polymorphisms in the RAGE gene on transcriptional regulation and their association with diabetic retinopathy. (PubMed id 11375354)1, 2, 4 Hudson B.I.... Grant P.J. (Diabetes 2001)
    2. Cloning and expression of a cell surface receptor for advanced glycosylation end products of proteins. (PubMed id 1378843)1, 2, 9 Neeper M.... Shaw A. (J. Biol. Chem. 1992)
    3. Novel splice variants of the receptor for advanced glycation end- products expressed in human vascular endothelial cells and pericytes, and their putative roles in diabetes-induced vascular injury. (PubMed id 12495433)1, 2, 9 Yonekura H.... Yamamoto H. (Biochem. J. 2003)
    4. Polymorphisms 1704G/T and 2184A/G in the RAGE gene are associated with antioxidant status. (PubMed id 11586486)1, 4, 9 KankovA! K....VA!cha J. (Metab. Clin. Exp. 2001)
    5. Polymorphisms in advanced glycosylation end product-specific receptor (AGER) gene, insulin resistance, and type 2 diabetes mellitus. (PubMed id 18796298)1, 4, 9 Goulart A.C....Zee R.Y. ( international journal of clinical chemistry 2008)
    6. Soluble RAGE, diabetic nephropathy and genetic variability in the AGER gene. (PubMed id 18615900)1, 4, 9 KankovA! K....Zima T. (Arch. Physiol. Biochem. 2008)
    7. -429T/C and -374T/A polymorphisms of RAGE gene promoter are not associated with diabetic retinopathy in Chinese patients with type 2 diabetes. (PubMed id 12941744)1, 4, 9 JiXiong X....ShuQin L. (Diabetes Care 2003)
    8. Association of Gly82Ser polymorphism in the RAGE gene with diabetic retinopathy in type II diabetic Asian Indian patients. (PubMed id 12477623)1, 4, 9 Kumaramanickavel G....Sharma T. (J. Diabetes Complicat. 2002)
    9. Three genes in the human MHC class III region near the junction with the class II: gene for receptor of advanced glycosylation end products, PBX2 homeobox gene and a notch homolog, human counterpart of mouse mammary tumor gene int-3. (PubMed id 7835890)1, 2, 9 Sugaya K.... Ikemura T. (Genomics 1994)
    10. Disulfide bonds within the C2 domain of RAGE play key roles in its dimerization and biogenesis. (PubMed id 23284645)1, 2 Wei W....Lin L. (PLoS ONE 2012)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 177 HGNC: 320 AceView: AGERandPBX2 Ensembl:ENSG00000204305 euGenes: HUgn177
    ECgene: AGER H-InvDB: AGER

    (According to HUGE)
    About This Section

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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
    About This Section

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    NameDescription
    PharmGKB entry for AGER Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for AGER Genetics and Cytogenetics in Oncology and Haematology

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for AGER gene:
    Search GeneIP for patents involving AGER

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, eBioscience, antibodies-online, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
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