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Aliases for AGBL5 Gene

Aliases for AGBL5 Gene

  • ATP/GTP Binding Protein-Like 5 2 3
  • ATP/GTP-Binding Protein-Like 5 3 4
  • Cytosolic Carboxypeptidase 5 2 3
  • CCP5 3 4
  • Cytosolic Carboxypeptidase-Like Protein 5 3
  • EC 3.4.17.- 4

External Ids for AGBL5 Gene

Summaries for AGBL5 Gene

GeneCards Summary for AGBL5 Gene

AGBL5 (ATP/GTP Binding Protein-Like 5) is a Protein Coding gene. GO annotations related to this gene include tubulin binding and metallocarboxypeptidase activity. An important paralog of this gene is AGBL2.

UniProtKB/Swiss-Prot for AGBL5 Gene

  • Metallocarboxypeptidase that mediates tubulin deglutamylation. Specifically catalyzes the deglutamylation of the branching point glutamate side chains generated by post-translational glutamylation in proteins such as tubulins. In contrast, it is not able to act as a long-chain deglutamylase that shortens long polyglutamate chains, a process catalyzed by AGTPBP1/CCP1, AGBL2/CCP2, AGBL3/CCP3, AGBL1/CCP4 and AGBL4/CCP6.

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for AGBL5 Gene

Genomics for AGBL5 Gene

Genomic Location for AGBL5 Gene

Start:
27,042,364 bp from pter
End:
27,070,622 bp from pter
Size:
28,259 bases
Orientation:
Plus strand

Genomic View for AGBL5 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for AGBL5 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for AGBL5 Gene

Regulatory Elements for AGBL5 Gene

Proteins for AGBL5 Gene

  • Protein details for AGBL5 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8NDL9-CBPC5_HUMAN
    Recommended name:
    Cytosolic carboxypeptidase-like protein 5
    Protein Accession:
    Q8NDL9
    Secondary Accessions:
    • A2VDI7
    • B7WPG9
    • B7Z7I7
    • D6W548
    • Q53SW0
    • Q53SZ0
    • Q96IK8
    • Q9H6V0
    • Q9H8P8

    Protein attributes for AGBL5 Gene

    Size:
    886 amino acids
    Molecular mass:
    97534 Da
    Cofactor:
    Name=Zn(2+); Xref=ChEBI:CHEBI:29105; Note=Binds 1 zinc ion per subunit.;
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=AAX93164.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305}; Sequence=AAY14655.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305}; Sequence=BAB15151.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305};

    Alternative splice isoforms for AGBL5 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for AGBL5 Gene

Proteomics data for AGBL5 Gene at MOPED

Post-translational modifications for AGBL5 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for AGBL5 Gene

Domains for AGBL5 Gene

Protein Domains for AGBL5 Gene

InterPro:
ProtoNet:

UniProtKB/Swiss-Prot:

CBPC5_HUMAN
Family:
  • Belongs to the peptidase M14 family.:
    • Q8NDL9
genes like me logo Genes that share domains with AGBL5: view

No data available for Gene Families for AGBL5 Gene

Function for AGBL5 Gene

Molecular function for AGBL5 Gene

UniProtKB/Swiss-Prot Function: Metallocarboxypeptidase that mediates tubulin deglutamylation. Specifically catalyzes the deglutamylation of the branching point glutamate side chains generated by post-translational glutamylation in proteins such as tubulins. In contrast, it is not able to act as a long-chain deglutamylase that shortens long polyglutamate chains, a process catalyzed by AGTPBP1/CCP1, AGBL2/CCP2, AGBL3/CCP3, AGBL1/CCP4 and AGBL4/CCP6.

Enzyme Numbers (IUBMB) for AGBL5 Gene

Gene Ontology (GO) - Molecular Function for AGBL5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004181 metallocarboxypeptidase activity ISS --
GO:0008270 zinc ion binding IEA --
GO:0015631 tubulin binding ISS --
genes like me logo Genes that share ontologies with AGBL5: view
genes like me logo Genes that share phenotypes with AGBL5: view

No data available for Animal Models , miRNA , Transcription Factor Targeting and HOMER Transcription for AGBL5 Gene

Localization for AGBL5 Gene

Subcellular locations from UniProtKB/Swiss-Prot for AGBL5 Gene

Cytoplasm, cytosol. Nucleus. Cytoplasm, cytoskeleton, spindle. Midbody. Note=Mainly cytoplasmic. Slight accumulation in the nucleus is observed (By similarity). Colocalizes with alpha-tubulin in the mitotic spindle and with midbody microtubules in the intercellular bridges formed during cytokinesis. {ECO:0000250 UniProtKB:Q09M02, ECO:0000269 PubMed:23085998}.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for AGBL5 Gene COMPARTMENTS Subcellular localization image for AGBL5 gene
Compartment Confidence
cytosol 4
nucleus 4

Gene Ontology (GO) - Cellular Components for AGBL5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus ISS --
GO:0005737 cytoplasm IDA --
GO:0005829 cytosol ISS --
GO:0030496 midbody IDA 23085998
GO:0072686 mitotic spindle IDA 23085998
genes like me logo Genes that share ontologies with AGBL5: view

Pathways for AGBL5 Gene

SuperPathways for AGBL5 Gene

No Data Available

Interacting Proteins for AGBL5 Gene

Selected Interacting proteins: Q8NDL9-CBPC5_HUMAN for AGBL5 Gene via MINT

Symbol External ID(s) Details
--

Gene Ontology (GO) - Biological Process for AGBL5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006508 proteolysis IEA --
GO:0035608 protein deglutamylation ISS --
GO:0035611 protein branching point deglutamylation ISS --
genes like me logo Genes that share ontologies with AGBL5: view

No data available for Pathways by source for AGBL5 Gene

Transcripts for AGBL5 Gene

Unigene Clusters for AGBL5 Gene

ATP/GTP binding protein-like 5:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for AGBL5 Gene

ExUns: 1 ^ 2a · 2b ^ 3 ^ 4 ^ 5a · 5b · 5c ^ 6a · 6b ^ 7a · 7b · 7c ^ 8 ^ 9a · 9b ^ 10a · 10b ^ 11a · 11b · 11c ^ 12a · 12b ^ 13 ^ 14a · 14b ^
SP1: - - - - -
SP2: - -
SP3: - -
SP4: - - - -
SP5: - - - -
SP6: -
SP7:
SP8:
SP9: -

ExUns: 15 ^ 16 ^ 17 ^ 18 ^ 19 ^ 20 ^ 21
SP1: - -
SP2:
SP3:
SP4:
SP5:
SP6:
SP7:
SP8: -
SP9:

Relevant External Links for AGBL5 Gene

GeneLoc Exon Structure for
AGBL5
ECgene alternative splicing isoforms for
AGBL5

Expression for AGBL5 Gene

mRNA expression in normal human tissues for AGBL5 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for AGBL5 Gene

This gene is overexpressed in Testis (12.4).

Integrated Proteomics: protein expression from ProteomicsDB and MOPED for AGBL5 Gene

SOURCE GeneReport for Unigene cluster for AGBL5 Gene Hs.138207

mRNA Expression by UniProt/SwissProt for AGBL5 Gene

Q8NDL9-CBPC5_HUMAN
Tissue specificity: Expressed in brain
genes like me logo Genes that share expressions with AGBL5: view

Orthologs for AGBL5 Gene

This gene was present in the common ancestor of chordates.

Orthologs for AGBL5 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia AGBL5 36
  • 99.66 (n)
  • 99.21 (a)
AGBL5 37
  • 99 (a)
OneToOne
cow
(Bos Taurus)
Mammalia AGBL5 36
  • 90.76 (n)
  • 91.8 (a)
AGBL5 37
  • 89 (a)
OneToOne
dog
(Canis familiaris)
Mammalia AGBL5 36
  • 90.29 (n)
  • 89.46 (a)
AGBL5 37
  • 90 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Agbl5 36
  • 87.13 (n)
  • 88.03 (a)
Agbl5 16
Agbl5 37
  • 83 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia AGBL5 37
  • 80 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia AGBL5 37
  • 73 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Agbl5 36
  • 86.07 (n)
  • 87.01 (a)
chicken
(Gallus gallus)
Aves AGBL5 37
  • 53 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia AGBL5 37
  • 66 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia agbl5 36
  • 66.42 (n)
  • 69.42 (a)
zebrafish
(Danio rerio)
Actinopterygii -- 36
agbl5 36
  • 65.92 (n)
  • 67.46 (a)
agbl5 37
  • 55 (a)
OneToOne
sea squirt
(Ciona savignyi)
Ascidiacea -- 37
  • 56 (a)
OneToOne
Species with no ortholog for AGBL5:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for AGBL5 Gene

ENSEMBL:
Gene Tree for AGBL5 (if available)
TreeFam:
Gene Tree for AGBL5 (if available)

Paralogs for AGBL5 Gene

Paralogs for AGBL5 Gene

genes like me logo Genes that share paralogs with AGBL5: view

Variants for AGBL5 Gene

Sequence variations from dbSNP and Humsavar for AGBL5 Gene

SNP ID Clin Chr 02 pos Sequence Context AA Info Type MAF
rs1058813 -- 27,059,381(+) CACCC(A/C)CCGGG reference, missense, nc-transcript-variant
rs1058814 -- 27,059,402(+) CGTCA(A/G)AGGTA missense, reference, nc-transcript-variant
rs1058815 -- 27,059,446(+) GTTGT(C/T)TGGGG reference, synonymous-codon, intron-variant
rs1065664 -- 27,059,415(+) CCAGT(C/T)TGGGA reference, synonymous-codon, intron-variant
rs1078809 -- 27,066,047(-) TCATG(A/G)GCTCA intron-variant

Structural Variations from Database of Genomic Variants (DGV) for AGBL5 Gene

Variant ID Type Subtype PubMed ID
nsv455974 CNV Loss 19166990
nsv817673 CNV Gain 17921354
nsv833603 CNV Loss 17160897
nsv873752 CNV Loss 21882294

Relevant External Links for AGBL5 Gene

HapMap Linkage Disequilibrium report
AGBL5

Disorders for AGBL5 Gene

Relevant External Links for AGBL5

Genetic Association Database (GAD)
AGBL5
Human Genome Epidemiology (HuGE) Navigator
AGBL5
genes like me logo Genes that share disorders with AGBL5: view

No data available for UniProtKB/Swiss-Prot for AGBL5 Gene

Publications for AGBL5 Gene

  1. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4
  2. Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study. (PMID: 20628086) Bailey S.D. … Anand S. (Diabetes Care 2010) 3 49
  3. Functional segregation and emerging role of cilia-related cytosolic carboxypeptidases (CCPs). (PMID: 23085998) Rodriguez de la Vega Otazo M. … Bautista J.M. (FASEB J. 2013) 3 4
  4. Cytosolic carboxypeptidase 5 removes I+- and I^-linked glutamates from tubulin. (PMID: 24022482) Berezniuk I. … Fricker L.D. (J. Biol. Chem. 2013) 2 3
  5. Genetic associations of variants in genes encoding HIV-dependency factors required for HIV-1 infection. (PMID: 21083371) Chinn L.W. … O'Brien S.J. (J. Infect. Dis. 2010) 49

Products for AGBL5 Gene

Sources for AGBL5 Gene

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