Free for academic non-profit institutions. Other users need a Commercial license

Aliases for AGBL5 Gene

Aliases for AGBL5 Gene

  • ATP/GTP Binding Protein-Like 5 2 3 5
  • ATP/GTP-Binding Protein-Like 5 3 4
  • Cytosolic Carboxypeptidase 5 2 3
  • CCP5 3 4
  • EC 3.4.17.- 4

External Ids for AGBL5 Gene

Previous GeneCards Identifiers for AGBL5 Gene

  • GC02P027128
  • GC02P027265

Summaries for AGBL5 Gene

GeneCards Summary for AGBL5 Gene

AGBL5 (ATP/GTP Binding Protein-Like 5) is a Protein Coding gene. GO annotations related to this gene include tubulin binding and metallocarboxypeptidase activity. An important paralog of this gene is AGBL2.

UniProtKB/Swiss-Prot for AGBL5 Gene

  • Metallocarboxypeptidase that mediates tubulin deglutamylation. Specifically catalyzes the deglutamylation of the branching point glutamate side chains generated by post-translational glutamylation in proteins such as tubulins. In contrast, it is not able to act as a long-chain deglutamylase that shortens long polyglutamate chains, a process catalyzed by AGTPBP1/CCP1, AGBL2/CCP2, AGBL3/CCP3, AGBL1/CCP4 and AGBL4/CCP6.

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for AGBL5 Gene

Genomics for AGBL5 Gene

Regulatory Elements for AGBL5 Gene

Genomic Location for AGBL5 Gene

Chromosome:
2
Start:
27,042,364 bp from pter
End:
27,070,622 bp from pter
Size:
28,259 bases
Orientation:
Plus strand

Genomic View for AGBL5 Gene

Genes around AGBL5 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
AGBL5 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for AGBL5 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for AGBL5 Gene

Proteins for AGBL5 Gene

  • Protein details for AGBL5 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8NDL9-CBPC5_HUMAN
    Recommended name:
    Cytosolic carboxypeptidase-like protein 5
    Protein Accession:
    Q8NDL9
    Secondary Accessions:
    • A2VDI7
    • B7WPG9
    • B7Z7I7
    • D6W548
    • Q53SW0
    • Q53SZ0
    • Q96IK8
    • Q9H6V0
    • Q9H8P8

    Protein attributes for AGBL5 Gene

    Size:
    886 amino acids
    Molecular mass:
    97534 Da
    Cofactor:
    Name=Zn(2+); Xref=ChEBI:CHEBI:29105;
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=AAX93164.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305}; Sequence=AAY14655.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305}; Sequence=BAB15151.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305};

    Alternative splice isoforms for AGBL5 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for AGBL5 Gene

Proteomics data for AGBL5 Gene at MOPED

Post-translational modifications for AGBL5 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Antibody Products

No data available for DME Specific Peptides for AGBL5 Gene

Domains & Families for AGBL5 Gene

Protein Domains for AGBL5 Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for AGBL5 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q8NDL9

UniProtKB/Swiss-Prot:

CBPC5_HUMAN :
  • Belongs to the peptidase M14 family.
Family:
  • Belongs to the peptidase M14 family.
genes like me logo Genes that share domains with AGBL5: view

No data available for Gene Families for AGBL5 Gene

Function for AGBL5 Gene

Molecular function for AGBL5 Gene

UniProtKB/Swiss-Prot Function:
Metallocarboxypeptidase that mediates tubulin deglutamylation. Specifically catalyzes the deglutamylation of the branching point glutamate side chains generated by post-translational glutamylation in proteins such as tubulins. In contrast, it is not able to act as a long-chain deglutamylase that shortens long polyglutamate chains, a process catalyzed by AGTPBP1/CCP1, AGBL2/CCP2, AGBL3/CCP3, AGBL1/CCP4 and AGBL4/CCP6.

Enzyme Numbers (IUBMB) for AGBL5 Gene

genes like me logo Genes that share phenotypes with AGBL5: view

Animal Model Products

CRISPR Products

miRNA for AGBL5 Gene

miRTarBase miRNAs that target AGBL5

No data available for Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for AGBL5 Gene

Localization for AGBL5 Gene

Subcellular locations from UniProtKB/Swiss-Prot for AGBL5 Gene

Cytoplasm, cytosol. Nucleus. Cytoplasm, cytoskeleton, spindle. Midbody. Note=Mainly cytoplasmic. Slight accumulation in the nucleus is observed (By similarity). Colocalizes with alpha-tubulin in the mitotic spindle and with midbody microtubules in the intercellular bridges formed during cytokinesis. {ECO:0000250 UniProtKB:Q09M02, ECO:0000269 PubMed:23085998}.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for AGBL5 Gene COMPARTMENTS Subcellular localization image for AGBL5 gene
Compartment Confidence
cytoskeleton 5
cytosol 5
nucleus 5

No data available for Gene Ontology (GO) - Cellular Components for AGBL5 Gene

Pathways & Interactions for AGBL5 Gene

SuperPathways for AGBL5 Gene

No Data Available

Interacting Proteins for AGBL5 Gene

Selected Interacting proteins: Q8NDL9-CBPC5_HUMAN for AGBL5 Gene via MINT

Symbol External ID(s) Details
--

Gene Ontology (GO) - Biological Process for AGBL5 Gene

None

No data available for Pathways by source and SIGNOR curated interactions for AGBL5 Gene

Drugs & Compounds for AGBL5 Gene

No Compound Related Data Available

Transcripts for AGBL5 Gene

Unigene Clusters for AGBL5 Gene

ATP/GTP binding protein-like 5:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for AGBL5 Gene

ExUns: 1 ^ 2a · 2b ^ 3 ^ 4 ^ 5a · 5b · 5c ^ 6a · 6b ^ 7a · 7b · 7c ^ 8 ^ 9a · 9b ^ 10a · 10b ^ 11a · 11b · 11c ^ 12a · 12b ^ 13 ^ 14a · 14b ^
SP1: - - - - -
SP2: - -
SP3: - -
SP4: - - - -
SP5: - - - -
SP6: -
SP7:
SP8:
SP9: -

ExUns: 15 ^ 16 ^ 17 ^ 18 ^ 19 ^ 20 ^ 21
SP1: - -
SP2:
SP3:
SP4:
SP5:
SP6:
SP7:
SP8: -
SP9:

Relevant External Links for AGBL5 Gene

GeneLoc Exon Structure for
AGBL5
ECgene alternative splicing isoforms for
AGBL5

Expression for AGBL5 Gene

mRNA expression in normal human tissues for AGBL5 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for AGBL5 Gene

This gene is overexpressed in Testis (x12.4).

Protein differential expression in normal tissues from HIPED for AGBL5 Gene

This gene is overexpressed in Heart (67.5).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for AGBL5 Gene



SOURCE GeneReport for Unigene cluster for AGBL5 Gene Hs.138207

mRNA Expression by UniProt/SwissProt for AGBL5 Gene

Q8NDL9-CBPC5_HUMAN
Tissue specificity: Expressed in brain.
genes like me logo Genes that share expression patterns with AGBL5: view

Protein tissue co-expression partners for AGBL5 Gene

- Elite partner

Primer Products

In Situ Assay Products

Orthologs for AGBL5 Gene

This gene was present in the common ancestor of chordates.

Orthologs for AGBL5 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia AGBL5 36
  • 99 (a)
OneToOne
AGBL5 35
  • 99.66 (n)
  • 99.21 (a)
cow
(Bos Taurus)
Mammalia AGBL5 35
  • 90.76 (n)
  • 91.8 (a)
AGBL5 36
  • 89 (a)
OneToOne
dog
(Canis familiaris)
Mammalia AGBL5 36
  • 90 (a)
OneToOne
AGBL5 35
  • 90.29 (n)
  • 89.46 (a)
mouse
(Mus musculus)
Mammalia Agbl5 16
Agbl5 36
  • 83 (a)
OneToOne
Agbl5 35
  • 87.13 (n)
  • 88.03 (a)
oppossum
(Monodelphis domestica)
Mammalia AGBL5 36
  • 80 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia AGBL5 36
  • 73 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Agbl5 35
  • 86.07 (n)
  • 87.01 (a)
chicken
(Gallus gallus)
Aves AGBL5 36
  • 53 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia AGBL5 36
  • 66 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia agbl5 35
  • 66.42 (n)
  • 69.42 (a)
zebrafish
(Danio rerio)
Actinopterygii -- 35
agbl5 35
  • 65.92 (n)
  • 67.46 (a)
agbl5 36
  • 55 (a)
OneToOne
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 56 (a)
OneToOne
Species with no ortholog for AGBL5:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for AGBL5 Gene

ENSEMBL:
Gene Tree for AGBL5 (if available)
TreeFam:
Gene Tree for AGBL5 (if available)

Paralogs for AGBL5 Gene

Paralogs for AGBL5 Gene

genes like me logo Genes that share paralogs with AGBL5: view

Variants for AGBL5 Gene

Sequence variations from dbSNP and Humsavar for AGBL5 Gene

SNP ID Clin Chr 02 pos Sequence Context AA Info Type
rs35804461 - 27,059,261(-) TACCA(C/T)CGGCA nc-transcript-variant, reference, missense
rs1078809 -- 27,066,047(-) TCATG(A/G)GCTCA intron-variant
rs2004575 -- 27,056,882(-) agtag(C/T)tggga intron-variant
rs3072661 -- 27,064,262(+) CCAAC(-/AAC)TCTCA intron-variant
rs3739090 -- 27,053,938(+) GTTTC(A/G)TGGAG nc-transcript-variant, reference, missense

Structural Variations from Database of Genomic Variants (DGV) for AGBL5 Gene

Variant ID Type Subtype PubMed ID
nsv455974 CNV Loss 19166990
nsv817673 CNV Gain 17921354
nsv833603 CNV Loss 17160897
nsv873752 CNV Loss 21882294

Variation tolerance for AGBL5 Gene

Residual Variation Intolerance Score: 11.1% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 3.40; 54.25% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for AGBL5 Gene

HapMap Linkage Disequilibrium report
AGBL5

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for AGBL5 Gene

Disorders for AGBL5 Gene

Relevant External Links for AGBL5

Genetic Association Database (GAD)
AGBL5
Human Genome Epidemiology (HuGE) Navigator
AGBL5
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
AGBL5

No disorders were found for AGBL5 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for AGBL5 Gene

Publications for AGBL5 Gene

  1. Functional segregation and emerging role of cilia-related cytosolic carboxypeptidases (CCPs). (PMID: 23085998) Rodriguez de la Vega Otazo M. … Bautista J.M. (FASEB J. 2013) 3 4 67
  2. Cytosolic carboxypeptidase 5 removes I+- and I^-linked glutamates from tubulin. (PMID: 24022482) Berezniuk I. … Fricker L.D. (J. Biol. Chem. 2013) 2 3
  3. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin E.L. … Gygi S.P. (Cell 2015) 3
  4. The SH3 domain of postsynaptic density 95 mediates inflammatory pain through phosphatidylinositol-3-kinase recruitment. (PMID: 20467438) Arbuckle M.I. … Grant S.G. (EMBO Rep. 2010) 3
  5. Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study. (PMID: 20628086) Bailey S.D. … Anand S. (Diabetes Care 2010) 3

Products for AGBL5 Gene

Sources for AGBL5 Gene

Back to Top

Content