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Category Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21

GIFtS
-

AGBL3 Gene

protein-coding GIFtS: 41
GCID: GC07P134671

ATP/GTP binding protein-like 3

Explore 1 disease affiliated with
AGBL3 via

MalaCards

our new
Human Malady Compendium

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc, ⁷Ensembl, ⁸DME, ⁹miRBase, and/or ¹⁰fRNAdb)
About This Section

Aliases
ATP/GTP Binding Protein-Like 3¹ ²		CCP3³
ATP/GTP-Binding Protein-Like 3² ³		EC 3.4.17.-³
MGC32955¹		EC 3.4.17⁸
Cytosolic Carboxypeptidase 3²

External Ids:	HGNC: 27981¹	Entrez Gene: 340351²	Ensembl: ENSG00000146856⁷	UniProtKB: Q8NEM8³

Export aliases for AGBL3 gene to outside databases

Previous GC identifers: GC07P134129 GC07P134321 GC07P128973

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

UniProtKB/Swiss-Prot: CBPC3_HUMAN, Q8NEM8

Function: Metallocarboxypeptidase that may play a role in the processing of tubulin

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section

RefSeq DNA sequence:

NC_000007.13 NC_018918.1 NT_007933.15 NT_079596.2

Regulatory elements:

SABiosciences Regulatory transcription factor binding sites in the AGBL3 gene promoter:
AML1a Pax-6 Pax-2 LUN-1 Tal-1beta YY1 Evi-1 AREB6 Pax-2b ITF-2
Other transcription factors

Browse SwitchGear Promoter luciferase reporter plasmids

Search SABiosciences Chromatin IP Primers for AGBL3

Epigenetics:

QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat AGBL3

Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 7q33 Ensembl cytogenetic band: 7q33 HGNC cytogenetic band: 7q33

AGBL3 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
AGBL3 gene location

GeneLoc information about chromosome 7 GeneLoc Exon Structure

GeneLoc location for GC07P134671: view genomic region (about GC identifiers)

Start:	134,671,259 bp from pter	End:	134,832,715 bp from pter
Size:	161,457 bases	Orientation:	plus strand

1 alternative location:

Chr7+,CRA_TCAG 134,015,578-134,164,887

(According to ¹UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to ²PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section

UniProtKB/Swiss-Prot: CBPC3_HUMAN, Q8NEM8 (See protein sequence)

Recommended Name: Cytosolic carboxypeptidase 3

Size: 1001 amino acids; 116011 Da

Cofactor: Binds 1 zinc ion per subunit (By similarity)

Subcellular location: Cytoplasm, cytosol (By similarity)

Secondary accessions: B7Z827 Q9H965

Alternative splicing: 4 isoforms: Q8NEM8-1 Q8NEM8-2 Q8NEM8-3 Q8NEM8-4 (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for AGBL3: NX_Q8NEM8

Post-translational modifications:

View modification sites using PhosphoSitePlus²

View neXtProt modification sites for NX_Q8NEM8

4 DME Specific Peptides for AGBL3 (Q8NEM8)

DAQLLRD

ARVHPGE

PMLNPDGV

KEGTGRVVMW

AGBL3 Protein expression data from MOPED and PaxDb: About this image

REFSEQ proteins: NP_848658.3

ENSEMBL proteins:

ENSP00000388275 ENSP00000275763 ENSP00000401220 ENSP00000412700 ENSP00000352343

ENSP00000395969

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Gene Ontology (GO): 1 cellular component term (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005829	cytosol	IEA	--

AGBL3 for ontologies About GeneDecksing

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(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

AGBL3 for domains About GeneDecksing

1 InterPro domain/family:

IPR000834 Peptidase_M14

Graphical View of Domain Structure for InterPro Entry Q8NEM8

ProtoNet protein and cluster: Q8NEM8

UniProtKB/Swiss-Prot: CBPC3_HUMAN, Q8NEM8

Similarity: Belongs to the peptidase M14 family

(According to ¹UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or ²DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
About This Section

Function Summary:

UniProtKB/Swiss-Prot: CBPC3_HUMAN, Q8NEM8

Function: Metallocarboxypeptidase that may play a role in the processing of tubulin

Enzyme Numbers (IUBMB): EC 3.4.17² EC 3.4.17.-¹

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Gene Ontology (GO): 2 molecular function terms (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0004181	metallocarboxypeptidase activity	IDA	17244817
GO:0008270	zinc ion binding	IEA	--

AGBL3 for ontologies About GeneDecksing

(Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to ¹UniProtKB, ²MINT, ³I2D, and/or ⁴STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
About This Section

Interactions:

Search SABiosciences Gene Network Central^TM Interacting Genes and Proteins Networks for AGBL3

Gene Ontology (GO): 1 biological process term (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0006508	proteolysis	IEA	--

AGBL3 for ontologies About GeneDecksing

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
About This Section

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Browse drugs & compounds from Enzo Life Sciences

Browse Tocris compounds for AGBL3
Search CenterWatch for drugs/clinical trials and news about AGBL3 / CBPC3

(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
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About This Section

REFSEQ mRNAs for AGBL3 gene:

NM_178563.3

Unigene Cluster for AGBL3:

ATP/GTP binding protein-like 3

Hs.648616 [show with all ESTs]

Unigene Representative Sequence: NM_178563

9 Ensembl transcripts including schematic representations, and UCSC links where relevant:

ENST00000436302(uc011kpw.2) ENST00000275763 ENST00000435976 ENST00000455283

ENST00000476700 ENST00000494702 ENST00000470839 ENST00000359383 ENST00000458078

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Additional cDNA sequence:

AK023045.1 AK302827.1 AK311252.1

8 DOTS entries:

DT.97766717 DT.95315740 DT.204533 DT.75125488 DT.102990 DT.91912898 DT.99938566 DT.102839651

24/31 AceView cDNA sequences (see all 31):

AU129966 BX106953 AA970632 CA313390 BX097304 AU119482 BX108115 AK023045

AA935135 BI821898 AI611811 AI674787 AK021841 BM825266 BX282589 AL832281

AW338204 BI460267 BC030651 NM_178563 AV700251 AA932946 BF475255 AU152023

GeneLoc Exon Structure

(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section

AGBL3 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: GAAAAAAATC

About this image
See AGBL3 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for AGBL3

SOURCE GeneReport for Unigene cluster: Hs.648616

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In Situ
Assay Products:

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(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD , ⁵MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or ⁶Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
About This Section

This gene was present in the common ancestor of animals.

Orthologs for AGBL3 gene from 3/19 species (see all 19) About this table

Organism	Taxonomic classification	Gene	Description	Human Similarity	Orthology Type	Details
chicken (Gallus gallus)	Aves	AGBL3¹	ATP/GTP binding protein-like 3	68.92(n) 65.44(a)		769745 XM_001233036.2 XP_001233037.2
lizard (Anolis carolinensis)	Reptilia	AGBL3⁶ --	--	65(a) 11(a)	1 ↔ 1 possible ortholog	5(27862179-27883587) 2(41899559-41919954)
fruit fly (Drosophila melanogaster)	Insecta	NnaD⁶	Drosophila Nna1 ortholog	19(a)	1 → many	X(13586325-13608468)

ENSEMBL Gene Tree for AGBL3 (if available)
TreeFam Gene Tree for AGBL3 (if available)

(Paralogs according to ¹HomoloGene,
²Ensembl, and ³SIMAP, Pseudogenes according to ⁴Pseudogene.org Build 68)
About This Section

Paralogs for AGBL3 gene

AGBL5² AGTPBP1² AGBL1² AGBL2² AGBL4²

18/34 SIMAP similar genes for AGBL3 using alignment to 5 protein entries: CBPC3_HUMAN (see all proteins) (see all similar genes):

SEPSECS KIAA0101 DYNC2LI1 SH3PXD2A KIAA1651 TMEM14B

pp12301 AURA2 LINC00596 HMGA2 SH2B3 PKN1

RBP7 MYB RPS6KA5 UTY C16orf89 GEMIN6

AGBL3 for paralogs About GeneDecksing

(SNPs/Variants according to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section

SNP ID	Valid	Clinical significance	Chr 7 pos	Sequence	#	AA Chg	Type	More	#	Allele freq	Pop	Total sample	More
Genomic Data					Transcription Related Data				Allele Frequencies
				--	--	--		--	--
rs61049217^1,2	C,	--	134079678(+)	`ATGTT-/TGGCTG`	1	--	int¹		0	--	--	--	--
rs199885929^1,2	C	--	134122158(-)	`TGGCTC/TTTTTT`	1	--	ds500¹		0	--	--	--	--
rs111293374^1,2		--	134122348(+)	`AAAGCG/AAAGCC`	1	--	ds500¹		1		CSA	2
rs73153761^1,2	C,F,	--	134122812(+)	`ATTCAG/ATGCAA`	1	--	nc-transcript-variant		3		WA NA EA	358
rs10268170^1,2	C,F,H,	--	134123457(+)	`CAGACG/AAATCC`	1	--	nc-transcript-variant		6		NS EA WA	524
rs73442109^1,2	C,	--	134123683(+)	`AGACCT/ACTTAG`	1	--	nc-transcript-variant		1		WA	2
rs28461869^1,2	C,	--	134123718(+)	`AGTAAA/CCATTG`	1	--	int¹		2		WA	120
rs76771668^1,2	F,	--	134124710(+)	`CAAGAA/TAATAC`	1	--	int¹		1		WA	118
rs75336600^1,2		--	134125352(+)	`GTGTAT/GATTGG`	1	--	int¹		1		NA	120
rs9719933^1,2	C,F	--	134125679(+)	`agataG/Cataga`	1	--	int¹		2		NA	4

HapMap Linkage Disequilibrium report for AGBL3 (134671259 - 134832715 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 1 variation for AGBL3
1 Indel: 41029

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(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
About This Section

AGBL3 for disorders About GeneDecksing

1 disease for AGBL3: About MalaCards

malaria

Human Genome Epidemiology (HuGE) Navigator: AGBL3 (1 document)

Export disorders for AGBL3 gene to outside databases

(in PubMed. Associations of this gene to articles via ¹Entrez Gene, ²UniProtKB/Swiss-Prot, ³HGNC, ⁴GAD, ⁵PharmGKB, ⁶HMDB, ⁷DrugBank, ⁸UniProtKB/TrEMBL, ⁹ Novoseek, and/or ¹⁰fRNAdb)
About This Section

PubMed articles for AGBL3 gene integrated from 9 sources:
(articles sorted by number of sources associating them with AGBL3)

Utopia: connect your pdf to the dynamic
world of online information

Nna1-like proteins are active metallocarboxypeptidase s of a new and diverse M14 subfamily. (PubMed id 17244817)^{1, 2} Rodriguez de la Vega M....AvilAcs F.X. (2007)
The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)^{1, 2} Gerhard D.S....Malek J. (2004)
Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)^{1, 2} Ota T.... Sugano S. (2004)
The DNA sequence of human chromosome 7. (PubMed id 12853948)^{1, 2} Hillier L.W.... Wilson R.K. (2003)
Genome-wide analysis of polymorphisms associated with cytokine responses in smallpox vaccine recipients. (PubMed id 22610502)¹ Kennedy R.B....Poland G.A. (2012)
Genome-wide association study of the child behavior c hecklist dysregulation profile. (PubMed id 21784300)¹ Mick E....Faraone S.V. (2011)
Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PubMed id 20379614)¹ Rose J.E....Uhl G.R. (2010)
Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)¹ Strausberg R.L....Marra M.A. (2002)

(in PubMed, OMIM, and NCBI Bookshelf)
About This Section

		AND	OR
Aliases
Free Text

Query String		PubMed OMIM NCBI Bookshelf
	(Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
About This Section

Entrez Gene: 340351	HGNC: 27981	AceView: LOC340351	Ensembl:ENSG00000146856	euGenes: HUgn340351
ECgene: AGBL3	H-InvDB: AGBL3

(According to HUGE)
About This Section

(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section

Name	Description
PharmGKB entry for AGBL3	Pharmacogenomics, SNPs, Pathways

Intellectual Property for AGBL3 gene
(Patent information from GeneIP, Licensable technologies from WIS Yeda, Salk, Tufts, IP news from LifeMap Sciences, Inc.)

About This Section

Patent Information for AGBL3 gene:
Search GeneIP for patents involving AGBL3

GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search

(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences),
In Situ Hybridization Assays from
Advanced Cell Diagnostics
About This Section


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GeneCards Homepage - Last full update: 18 Mar 2013 - Incrementals: 21 Mar 2013 , 15 Apr 2013 , 26 Apr 2013

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Category			VWF (GIFTS: 73) von Willebrand factor
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The GeneCards human gene database gene index: 1 3 5 6 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

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Developed at the Crown Human Genome Center, Department of Molecular Genetics, the Weizmann Institute of Science

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AGBL3 Gene

ATP/GTP binding protein-like 3

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AGBL3 Gene

ATP/GTP binding protein-like 3

Aliasesfor AGBL3 gene

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Genomic Viewsfor AGBL3 gene

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Protein Domains /Familiesfor AGBL3 gene

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for AGBL3 gene

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for AGBL3 gene

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for AGBL3 gene

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