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Aliases for AGBL3 Gene

Aliases for AGBL3 Gene

  • ATP/GTP Binding Protein-Like 3 2 3
  • ATP/GTP-Binding Protein-Like 3 3 4
  • CCP3 3 4
  • Cytosolic Carboxypeptidase 3 3
  • EC 3.4.17.- 4
  • EC 3.4.17 63

External Ids for AGBL3 Gene

Previous GeneCards Identifiers for AGBL3 Gene

  • GC07P134129
  • GC07P134321
  • GC07P134671
  • GC07P128973

Summaries for AGBL3 Gene

GeneCards Summary for AGBL3 Gene

AGBL3 (ATP/GTP Binding Protein-Like 3) is a Protein Coding gene. GO annotations related to this gene include metallocarboxypeptidase activity. An important paralog of this gene is AGBL2.

UniProtKB/Swiss-Prot for AGBL3 Gene

  • Metallocarboxypeptidase that mediates both deglutamylation and deaspartylation of target proteins. Catalyzes the deglutamylation of polyglutamate side chains generated by post-translational polyglutamylation in proteins such as tubulins. Also removes gene-encoded polyglutamates or polyaspartates from the carboxy-terminus of target proteins such as MYLK. Does not show detyrosinase or deglycylase activities from the carboxy-terminus of tubulin.

  • Isoform 2: Metallocarboxypeptidase that mediates tubulin deglutamylation.

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for AGBL3 Gene

Genomics for AGBL3 Gene

Regulatory Elements for AGBL3 Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for AGBL3 Gene

Start:
134,986,508 bp from pter
End:
135,147,963 bp from pter
Size:
161,456 bases
Orientation:
Plus strand

Genomic View for AGBL3 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for AGBL3 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for AGBL3 Gene

Proteins for AGBL3 Gene

  • Protein details for AGBL3 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8NEM8-CBPC3_HUMAN
    Recommended name:
    Cytosolic carboxypeptidase 3
    Protein Accession:
    Q8NEM8
    Secondary Accessions:
    • B7Z827
    • Q9H965

    Protein attributes for AGBL3 Gene

    Size:
    1001 amino acids
    Molecular mass:
    116011 Da
    Cofactor:
    Name=Zn(2+); Xref=ChEBI:CHEBI:29105; Note=Binds 1 zinc ion per subunit.;
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for AGBL3 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for AGBL3 Gene

Proteomics data for AGBL3 Gene at MOPED

Selected DME Specific Peptides for AGBL3 Gene

Post-translational modifications for AGBL3 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for AGBL3 Gene

Domains for AGBL3 Gene

Protein Domains for AGBL3 Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for AGBL3 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q8NEM8

UniProtKB/Swiss-Prot:

CBPC3_HUMAN :
  • Q8NEM8
Family:
  • Belongs to the peptidase M14 family.
genes like me logo Genes that share domains with AGBL3: view

No data available for Gene Families for AGBL3 Gene

Function for AGBL3 Gene

Molecular function for AGBL3 Gene

UniProtKB/Swiss-Prot Function:
Metallocarboxypeptidase that mediates both deglutamylation and deaspartylation of target proteins. Catalyzes the deglutamylation of polyglutamate side chains generated by post-translational polyglutamylation in proteins such as tubulins. Also removes gene-encoded polyglutamates or polyaspartates from the carboxy-terminus of target proteins such as MYLK. Does not show detyrosinase or deglycylase activities from the carboxy-terminus of tubulin.
UniProtKB/Swiss-Prot Function:
Isoform 2: Metallocarboxypeptidase that mediates tubulin deglutamylation.

Enzyme Numbers (IUBMB) for AGBL3 Gene

Gene Ontology (GO) - Molecular Function for AGBL3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004181 metallocarboxypeptidase activity IDA 17244817
GO:0008270 zinc ion binding IEA --
genes like me logo Genes that share ontologies with AGBL3: view

Animal Model Products

CRISPR Products

miRNA for AGBL3 Gene

miRTarBase miRNAs that target AGBL3

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for AGBL3

In Situ Assay Products

Flow Cytometry Products

No data available for Phenotypes , Animal Models , Transcription Factor Targeting and HOMER Transcription for AGBL3 Gene

Localization for AGBL3 Gene

Subcellular locations from UniProtKB/Swiss-Prot for AGBL3 Gene

Cytoplasm, cytosol.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for AGBL3 Gene COMPARTMENTS Subcellular localization image for AGBL3 gene
Compartment Confidence
cytosol 2
nucleus 2
mitochondrion 1

Gene Ontology (GO) - Cellular Components for AGBL3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm --
GO:0005829 cytosol IEA --
genes like me logo Genes that share ontologies with AGBL3: view

Pathways for AGBL3 Gene

SuperPathways for AGBL3 Gene

No Data Available

Interacting Proteins for AGBL3 Gene

Gene Ontology (GO) - Biological Process for AGBL3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006508 proteolysis IEA --
GO:0035610 protein side chain deglutamylation IDA 25103237
genes like me logo Genes that share ontologies with AGBL3: view

No data available for Pathways by source for AGBL3 Gene

Transcripts for AGBL3 Gene

Unigene Clusters for AGBL3 Gene

ATP/GTP binding protein-like 3:
Representative Sequences:

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for AGBL3

Primer Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for AGBL3 Gene

No ASD Table

Relevant External Links for AGBL3 Gene

GeneLoc Exon Structure for
AGBL3
ECgene alternative splicing isoforms for
AGBL3

Expression for AGBL3 Gene

mRNA expression in normal human tissues for AGBL3 Gene

mRNA differential expression in normal tissues according to GTEx for AGBL3 Gene

This gene is overexpressed in Testis (9.3).

Protein differential expression in normal tissues for AGBL3 Gene

This gene is overexpressed in Placenta (23.4), Fetal gut (18.0), and Esophagus (6.9).

Integrated Proteomics: protein expression from ProteomicsDB and MOPED for AGBL3 Gene

SOURCE GeneReport for Unigene cluster for AGBL3 Gene Hs.648616

genes like me logo Genes that share expressions with AGBL3: view

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA Expression by UniProt/SwissProt and Expression partners for AGBL3 Gene

Orthologs for AGBL3 Gene

This gene was present in the common ancestor of animals.

Orthologs for AGBL3 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia AGBL3 35
  • 87.23 (n)
  • 82.31 (a)
AGBL3 36
  • 75 (a)
OneToOne
dog
(Canis familiaris)
Mammalia AGBL3 35
  • 87.24 (n)
  • 82.74 (a)
AGBL3 36
  • 78 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Agbl3 35
  • 82.79 (n)
  • 77.35 (a)
Agbl3 16
Agbl3 36
  • 71 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia AGBL3 35
  • 99.71 (n)
  • 99.67 (a)
AGBL3 36
  • 100 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Agbl3 35
  • 83.24 (n)
  • 78.36 (a)
platypus
(Ornithorhynchus anatinus)
Mammalia AGBL3 36
  • 61 (a)
OneToOne
chicken
(Gallus gallus)
Aves AGBL3 35
  • 65.01 (n)
  • 59.16 (a)
AGBL3 36
  • 68 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia AGBL3 36
  • 67 (a)
OneToOne
fruit fly
(Drosophila melanogaster)
Insecta NnaD 36
  • 23 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 69 (a)
OneToMany
Species with no ortholog for AGBL3:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for AGBL3 Gene

ENSEMBL:
Gene Tree for AGBL3 (if available)
TreeFam:
Gene Tree for AGBL3 (if available)

Paralogs for AGBL3 Gene

Paralogs for AGBL3 Gene

genes like me logo Genes that share paralogs with AGBL3: view

Variants for AGBL3 Gene

Sequence variations from dbSNP and Humsavar for AGBL3 Gene

SNP ID Clin Chr 07 pos Sequence Context AA Info Type MAF
rs1137566 -- 134,995,449(+) CACCA(G/T)CAGCA intron-variant
rs1142763 -- 135,128,246(+) gagat(C/T)gcacc intron-variant
rs1962205 -- 135,091,509(+) GTGTT(G/T)TTCAC intron-variant
rs1962522 -- 135,101,597(+) CTGGT(A/C)ACTTC intron-variant
rs1986359 -- 135,107,666(-) TTGCC(A/G)TATGG intron-variant

Structural Variations from Database of Genomic Variants (DGV) for AGBL3 Gene

Variant ID Type Subtype PubMed ID
nsv527174 CNV Loss 19592680
nsv889225 CNV Loss 21882294
esv2676287 CNV Deletion 23128226
esv2735185 CNV Deletion 23290073
esv2662841 CNV Deletion 23128226
nsv523222 CNV Gain 19592680

Relevant External Links for AGBL3 Gene

HapMap Linkage Disequilibrium report
AGBL3

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for AGBL3 Gene

Disorders for AGBL3 Gene

Relevant External Links for AGBL3

Genetic Association Database (GAD)
AGBL3
Human Genome Epidemiology (HuGE) Navigator
AGBL3

No disorders were found for AGBL3 Gene.

No data available for MalaCards , OMIM , UniProtKB/Swiss-Prot , University of Copenhagen DISEASES , Novoseek inferred disease relationships and Genatlas for AGBL3 Gene

Publications for AGBL3 Gene

  1. The DNA sequence of human chromosome 7. (PMID: 12853948) Hillier L.W. … Wilson R.K. (Nature 2003) 3 4
  2. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4
  3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4
  4. Nna1-like proteins are active metallocarboxypeptidases of a new and diverse M14 subfamily. (PMID: 17244817) Rodriguez de la Vega M. … Aviles F.X. (FASEB J. 2007) 3 4
  5. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PMID: 20379614) Rose J.E. … Uhl G.R. (Mol. Med. 2010) 3 48

Products for AGBL3 Gene

Sources for AGBL3 Gene

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