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Aliases for AGBL2 Gene

Aliases for AGBL2 Gene

  • ATP/GTP Binding Protein-Like 2 2 3
  • Cytoplasmic Carboxypeptidase 2 2 3
  • CCP2 3 4
  • ATP/GTP-Binding Protein-Like 2 4
  • Cytosolic Carboxypeptidase 2 3
  • EC 3.4.17.- 4
  • EC 3.4.17 63

External Ids for AGBL2 Gene

Previous GeneCards Identifiers for AGBL2 Gene

  • GC11M047638
  • GC11M047681
  • GC11M047387

Summaries for AGBL2 Gene

GeneCards Summary for AGBL2 Gene

AGBL2 (ATP/GTP Binding Protein-Like 2) is a Protein Coding gene. GO annotations related to this gene include metallocarboxypeptidase activity. An important paralog of this gene is AGBL3.

UniProtKB/Swiss-Prot for AGBL2 Gene

  • Metallocarboxypeptidase that mediates deglutamylation of target proteins. Catalyzes the deglutamylation of polyglutamate side chains generated by post-translational polyglutamylation in proteins such as tubulins. Also removes gene-encoded polyglutamates from the carboxy-terminus of target proteins such as MYLK. Does not show detyrosinase or deglycylase activities from the carboxy-terminus of tubulin.

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for AGBL2 Gene

Genomics for AGBL2 Gene

Regulatory Elements for AGBL2 Gene

Genomic Location for AGBL2 Gene

Start:
47,659,486 bp from pter
End:
47,715,389 bp from pter
Size:
55,904 bases
Orientation:
Minus strand

Genomic View for AGBL2 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for AGBL2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for AGBL2 Gene

Proteins for AGBL2 Gene

  • Protein details for AGBL2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q5U5Z8-CBPC2_HUMAN
    Recommended name:
    Cytosolic carboxypeptidase 2
    Protein Accession:
    Q5U5Z8
    Secondary Accessions:
    • A8MPX2
    • Q53FV5
    • Q8IV57
    • Q9H5C0

    Protein attributes for AGBL2 Gene

    Size:
    902 amino acids
    Molecular mass:
    104194 Da
    Cofactor:
    Name=Zn(2+); Xref=ChEBI:CHEBI:29105; Note=Binds 1 zinc ion per subunit.;
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=BAB15707.1; Type=Erroneous termination; Positions=797; Note=Translated as Lys.; Evidence={ECO:0000305}; Sequence=BAD96891.1; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=BAD96896.1; Type=Erroneous initiation; Evidence={ECO:0000305};

    Alternative splice isoforms for AGBL2 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for AGBL2 Gene

Proteomics data for AGBL2 Gene at MOPED

Selected DME Specific Peptides for AGBL2 Gene

Post-translational modifications for AGBL2 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Domains for AGBL2 Gene

Protein Domains for AGBL2 Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for AGBL2 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q5U5Z8

UniProtKB/Swiss-Prot:

CBPC2_HUMAN :
  • Q5U5Z8
Family:
  • Belongs to the peptidase M14 family.
genes like me logo Genes that share domains with AGBL2: view

No data available for Gene Families for AGBL2 Gene

Function for AGBL2 Gene

Molecular function for AGBL2 Gene

UniProtKB/Swiss-Prot EnzymeRegulation: Inhibited by RARRES1.
UniProtKB/Swiss-Prot Function: Metallocarboxypeptidase that mediates deglutamylation of target proteins. Catalyzes the deglutamylation of polyglutamate side chains generated by post-translational polyglutamylation in proteins such as tubulins. Also removes gene-encoded polyglutamates from the carboxy-terminus of target proteins such as MYLK. Does not show detyrosinase or deglycylase activities from the carboxy-terminus of tubulin.

Enzyme Numbers (IUBMB) for AGBL2 Gene

Gene Ontology (GO) - Molecular Function for AGBL2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004181 metallocarboxypeptidase activity ISS --
GO:0008270 zinc ion binding IEA --
genes like me logo Genes that share ontologies with AGBL2: view

Animal Model Products

CRISPR Products

miRNA for AGBL2 Gene

miRTarBase miRNAs that target AGBL2

No data available for Phenotypes , Animal Models , Transcription Factor Targeting and HOMER Transcription for AGBL2 Gene

Localization for AGBL2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for AGBL2 Gene

Cytoplasm, cytosol. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome, centriole. Cytoplasm, cytoskeleton, cilium basal body. Note=Colocalizes with gamma-tubulin in the centrioles and with glutamylated tubulin in the basal bodies of ciliated cells. {ECO:0000269 PubMed:23085998}.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for AGBL2 Gene COMPARTMENTS Subcellular localization image for AGBL2 gene
Compartment Confidence
cytosol 4
nucleus 2
mitochondrion 1

Gene Ontology (GO) - Cellular Components for AGBL2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005814 centriole IDA 23085998
GO:0005829 cytosol ISS --
GO:0036064 ciliary basal body IDA 23085998
genes like me logo Genes that share ontologies with AGBL2: view

Pathways for AGBL2 Gene

SuperPathways for AGBL2 Gene

No Data Available

Interacting Proteins for AGBL2 Gene

Selected Interacting proteins: Q5U5Z8-CBPC2_HUMAN for AGBL2 Gene via I2D

Gene Ontology (GO) - Biological Process for AGBL2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006508 proteolysis IEA --
GO:0035610 protein side chain deglutamylation ISS --
genes like me logo Genes that share ontologies with AGBL2: view

No data available for Pathways by source for AGBL2 Gene

Transcripts for AGBL2 Gene

Unigene Clusters for AGBL2 Gene

ATP/GTP binding protein-like 2:
Representative Sequences:

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for AGBL2

Primer Products

  • OriGene qSTAR qPCR primer pairs in human,mouse,rat for AGBL2

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for AGBL2 Gene

ExUns: 1a · 1b · 1c ^ 2 ^ 3a · 3b ^ 4 ^ 5 ^ 6a · 6b ^ 7 ^ 8 ^ 9 ^ 10a · 10b ^ 11a · 11b ^ 12a · 12b ^ 13a · 13b ^ 14 ^ 15 ^ 16 ^ 17 ^ 18 ^
SP1: - - - -
SP2: - - - - - -
SP3: -
SP4: - - - - - -
SP5: - - - -
SP6: -
SP7: - - -
SP8: - -
SP9: - -

ExUns: 19 ^ 20 ^ 21 ^ 22
SP1:
SP2:
SP3:
SP4:
SP5:
SP6:
SP7:
SP8:
SP9:

Relevant External Links for AGBL2 Gene

GeneLoc Exon Structure for
AGBL2
ECgene alternative splicing isoforms for
AGBL2

Expression for AGBL2 Gene

mRNA expression in normal human tissues for AGBL2 Gene

mRNA differential expression in normal tissues according to GTEx for AGBL2 Gene

This gene is overexpressed in Testis (15.4).

Integrated Proteomics: protein expression from ProteomicsDB and MOPED for AGBL2 Gene

SOURCE GeneReport for Unigene cluster for AGBL2 Gene Hs.147377

genes like me logo Genes that share expressions with AGBL2: view

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and mRNA Expression by UniProt/SwissProt for AGBL2 Gene

Orthologs for AGBL2 Gene

This gene was present in the common ancestor of animals.

Orthologs for AGBL2 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia AGBL2 35
  • 99.59 (n)
  • 99.33 (a)
AGBL2 36
  • 99 (a)
OneToOne
dog
(Canis familiaris)
Mammalia AGBL2 35
  • 88.23 (n)
  • 86.53 (a)
AGBL2 36
  • 83 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Agbl2 35
  • 83.55 (n)
  • 80.3 (a)
Agbl2 16
Agbl2 36
  • 80 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia AGBL2 36
  • 59 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia AGBL2 36
  • 67 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Agbl2 35
  • 82.39 (n)
  • 81.56 (a)
chicken
(Gallus gallus)
Aves AGBL2 35
  • 63.55 (n)
  • 68.48 (a)
AGBL2 36
  • 67 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia AGBL2 36
  • 60 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia agbl2 35
  • 63.4 (n)
  • 62.17 (a)
Str.18052 35
zebrafish
(Danio rerio)
Actinopterygii agbl2 35
  • 62.28 (n)
  • 62.5 (a)
agbl2 36
  • 40 (a)
OneToOne
fruit fly
(Drosophila melanogaster)
Insecta NnaD 36
  • 25 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 61 (a)
OneToMany
Species with no ortholog for AGBL2:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • cow (Bos Taurus)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for AGBL2 Gene

ENSEMBL:
Gene Tree for AGBL2 (if available)
TreeFam:
Gene Tree for AGBL2 (if available)

Paralogs for AGBL2 Gene

Paralogs for AGBL2 Gene

Selected SIMAP similar genes for AGBL2 Gene using alignment to 9 proteins:

genes like me logo Genes that share paralogs with AGBL2: view

Variants for AGBL2 Gene

Sequence variations from dbSNP and Humsavar for AGBL2 Gene

SNP ID Clin Chr 11 pos Sequence Context AA Info Type MAF
rs936444 -- 47,686,448(+) TCTGG(G/T)TTTTT intron-variant
rs936445 -- 47,686,471(+) ttttG(G/T)AAAGG intron-variant
rs936446 -- 47,686,473(+) ttGGA(A/G)AGGCA intron-variant
rs1017730 -- 47,711,942(-) gccag(C/T)acacc intron-variant
rs1056387 -- 47,659,818(-) TCAAA(A/C)TCTAT utr-variant-3-prime, intron-variant

Structural Variations from Database of Genomic Variants (DGV) for AGBL2 Gene

Variant ID Type Subtype PubMed ID
nsv832142 CNV Loss 17160897
nsv509405 CNV Insertion 20534489
nsv469858 CNV Gain 16826518
nsv315 CNV Insertion 18451855
nsv832143 CNV Loss 17160897

Relevant External Links for AGBL2 Gene

HapMap Linkage Disequilibrium report
AGBL2

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for AGBL2 Gene

Disorders for AGBL2 Gene

No disorders were found for AGBL2 Gene.

No data available for UniProtKB/Swiss-Prot for AGBL2 Gene

Publications for AGBL2 Gene

  1. Tumor suppressor RARRES1 interacts with cytoplasmic carboxypeptidase AGBL2 to regulate the I+-tubulin tyrosination cycle. (PMID: 21303978) Sahab Z.J. … Byers S.W. (Cancer Res. 2011) 2 3 4
  2. Functional segregation and emerging role of cilia-related cytosolic carboxypeptidases (CCPs). (PMID: 23085998) Rodriguez de la Vega Otazo M. … Bautista J.M. (FASEB J. 2013) 3 4
  3. Identification of candidate liver tumor suppressor genes from human 11p11.2 by transcription mapping of microcell hybrid cell lines. (PMID: 12738998) Jahn J.E. … Coleman W.B. (Int. J. Oncol. 2003) 2 3
  4. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4
  5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4

Products for AGBL2 Gene

Sources for AGBL2 Gene

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