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Aliases for AGBL2 Gene

Aliases for AGBL2 Gene

  • ATP/GTP Binding Protein Like 2 2 3 5
  • Cytoplasmic Carboxypeptidase 2 2 3
  • CCP2 3 4
  • Testis Tissue Sperm-Binding Protein Li 96mP 3
  • ATP/GTP-Binding Protein-Like 2 4
  • Cytosolic Carboxypeptidase 2 3
  • EC 3.4.17.- 4
  • EC 3.4.17 61

External Ids for AGBL2 Gene

Previous GeneCards Identifiers for AGBL2 Gene

  • GC11M047638
  • GC11M047681
  • GC11M047387
  • GC11M047856
  • GC11M047960
  • GC11M050807
  • GC11M051602

Summaries for AGBL2 Gene

GeneCards Summary for AGBL2 Gene

AGBL2 (ATP/GTP Binding Protein Like 2) is a Protein Coding gene. Diseases associated with AGBL2 include Dyskinesia Of Esophagus and Bone Inflammation Disease. GO annotations related to this gene include metallocarboxypeptidase activity. An important paralog of this gene is AGBL3.

UniProtKB/Swiss-Prot for AGBL2 Gene

  • Metallocarboxypeptidase that mediates deglutamylation of target proteins. Catalyzes the deglutamylation of polyglutamate side chains generated by post-translational polyglutamylation in proteins such as tubulins. Also removes gene-encoded polyglutamates from the carboxy-terminus of target proteins such as MYLK. Does not show detyrosinase or deglycylase activities from the carboxy-terminus of tubulin.

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for AGBL2 Gene

Genomics for AGBL2 Gene

Regulatory Elements for AGBL2 Gene

Enhancers for AGBL2 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH11F047506 1.7 FANTOM5 Ensembl ENCODE 9.8 +201.9 201889 14.6 HDGF PKNOX1 WRNIP1 ZFP64 ZNF493 SIN3A FEZF1 ZNF2 ZNF121 GATA2 NUP160 FNBP4 ENSG00000200090 ENSG00000270060 C1QTNF4 DDB2 ZNF408 CELF1 SLC39A13 NDUFS3
GH11F047498 1.2 Ensembl ENCODE 9.8 +216.2 216189 2.4 ZNF493 WRNIP1 ZFP64 RAD21 ZNF155 YY1 ZEB1 ZNF354C ZNF138 KLF7 NUP160 FNBP4 ENSG00000200090 ENSG00000270060 DDB2 ZNF408 SLC39A13 KBTBD4 NDUFS3 PTPMT1
GH11F047606 0.8 Ensembl ENCODE 10.4 +107.7 107708 1.9 PBX2 BHLHE40 HMBOX1 FOS EBF1 MAFK ZIC2 FNBP4 FAM180B KBTBD4 NDUFS3 CELF1 PTPMT1 ENSG00000231880 RNU5E-10P MTCH2 AGBL2
GH11F047532 0.8 Ensembl ENCODE 9.3 +181.9 181889 2.2 RFX1 PRDM10 ZNF384 ZNF18 C1QTNF4 NDUFS3 ENSG00000231880 RNU5E-10P KBTBD4 MTCH2 FNBP4 AGBL2 PACSIN3 ENSG00000270072
GH11F047611 0.7 Ensembl ENCODE 10.3 +103.6 103631 0.9 IKZF1 SPI1 FAM180B CELF1 NDUFS3 PTPMT1 KBTBD4 MTCH2 ENSG00000231880 RNU5E-10P RAPSN AGBL2
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around AGBL2 on UCSC Golden Path with GeneCards custom track

Promoters for AGBL2 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000109066 189 1201 HDGF ZFP64 ARID4B SIN3A DMAP1 ZNF48 ZNF143 SP5 MXD4 MIER2

Genomic Location for AGBL2 Gene

Chromosome:
11
Start:
47,659,169 bp from pter
End:
47,715,389 bp from pter
Size:
56,221 bases
Orientation:
Minus strand

Genomic View for AGBL2 Gene

Genes around AGBL2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
AGBL2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for AGBL2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for AGBL2 Gene

Proteins for AGBL2 Gene

  • Protein details for AGBL2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q5U5Z8-CBPC2_HUMAN
    Recommended name:
    Cytosolic carboxypeptidase 2
    Protein Accession:
    Q5U5Z8
    Secondary Accessions:
    • A8MPX2
    • Q53FV5
    • Q8IV57
    • Q9H5C0

    Protein attributes for AGBL2 Gene

    Size:
    902 amino acids
    Molecular mass:
    104194 Da
    Cofactor:
    Name=Zn(2+); Xref=ChEBI:CHEBI:29105;
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=BAB15707.1; Type=Erroneous termination; Positions=797; Note=Translated as Lys.; Evidence={ECO:0000305}; Sequence=BAD96891.1; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=BAD96896.1; Type=Erroneous initiation; Evidence={ECO:0000305};

    Alternative splice isoforms for AGBL2 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for AGBL2 Gene

Selected DME Specific Peptides for AGBL2 Gene

Q5U5Z8:
  • ARVHPGE
  • DAQLLRD
  • KEGTGRVVMW
  • PMLNPDGV
  • CDFHGHS

Post-translational modifications for AGBL2 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Domains & Families for AGBL2 Gene

Protein Domains for AGBL2 Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for AGBL2 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q5U5Z8

UniProtKB/Swiss-Prot:

CBPC2_HUMAN :
  • Belongs to the peptidase M14 family.
Family:
  • Belongs to the peptidase M14 family.
genes like me logo Genes that share domains with AGBL2: view

No data available for Gene Families for AGBL2 Gene

Function for AGBL2 Gene

Molecular function for AGBL2 Gene

UniProtKB/Swiss-Prot EnzymeRegulation:
Inhibited by RARRES1.
UniProtKB/Swiss-Prot Function:
Metallocarboxypeptidase that mediates deglutamylation of target proteins. Catalyzes the deglutamylation of polyglutamate side chains generated by post-translational polyglutamylation in proteins such as tubulins. Also removes gene-encoded polyglutamates from the carboxy-terminus of target proteins such as MYLK. Does not show detyrosinase or deglycylase activities from the carboxy-terminus of tubulin.

Enzyme Numbers (IUBMB) for AGBL2 Gene

Gene Ontology (GO) - Molecular Function for AGBL2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004181 metallocarboxypeptidase activity IEA,ISS --
GO:0008233 peptidase activity IEA --
GO:0008237 metallopeptidase activity IEA --
GO:0008270 zinc ion binding IEA --
GO:0016787 hydrolase activity IEA --
genes like me logo Genes that share ontologies with AGBL2: view
genes like me logo Genes that share phenotypes with AGBL2: view

Animal Model Products

  • Taconic Biosciences Mouse Models for AGBL2

miRNA for AGBL2 Gene

miRTarBase miRNAs that target AGBL2

Inhibitory RNA Products

Flow Cytometry Products

No data available for Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for AGBL2 Gene

Localization for AGBL2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for AGBL2 Gene

Cytoplasm, cytosol. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome, centriole. Cytoplasm, cytoskeleton, cilium basal body. Note=Colocalizes with gamma-tubulin in the centrioles and with glutamylated tubulin in the basal bodies of ciliated cells. {ECO:0000269 PubMed:23085998}.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for AGBL2 gene
Compartment Confidence
cytoskeleton 5
cytosol 5
nucleus 2
extracellular 1
mitochondrion 1

Gene Ontology (GO) - Cellular Components for AGBL2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm IEA --
GO:0005814 centriole IEA,IDA 23085998
GO:0005829 cytosol ISS --
GO:0005856 cytoskeleton IEA --
GO:0036064 ciliary basal body IDA 23085998
genes like me logo Genes that share ontologies with AGBL2: view

Pathways & Interactions for AGBL2 Gene

SuperPathways for AGBL2 Gene

No Data Available

Interacting Proteins for AGBL2 Gene

Gene Ontology (GO) - Biological Process for AGBL2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006508 proteolysis IEA --
GO:0035610 protein side chain deglutamylation ISS --
genes like me logo Genes that share ontologies with AGBL2: view

No data available for Pathways by source and SIGNOR curated interactions for AGBL2 Gene

Transcripts for AGBL2 Gene

Unigene Clusters for AGBL2 Gene

ATP/GTP binding protein-like 2:
Representative Sequences:

Inhibitory RNA Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for AGBL2 Gene

ExUns: 1a · 1b · 1c ^ 2 ^ 3a · 3b ^ 4 ^ 5 ^ 6a · 6b ^ 7 ^ 8 ^ 9 ^ 10a · 10b ^ 11a · 11b ^ 12a · 12b ^ 13a · 13b ^ 14 ^ 15 ^ 16 ^ 17 ^ 18 ^
SP1: - - - -
SP2: - - - - - -
SP3: -
SP4: - - - - - -
SP5: - - - -
SP6: -
SP7: - - -
SP8: - -
SP9: - -

ExUns: 19 ^ 20 ^ 21 ^ 22
SP1:
SP2:
SP3:
SP4:
SP5:
SP6:
SP7:
SP8:
SP9:

Relevant External Links for AGBL2 Gene

GeneLoc Exon Structure for
AGBL2
ECgene alternative splicing isoforms for
AGBL2

Expression for AGBL2 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for AGBL2 Gene

mRNA differential expression in normal tissues according to GTEx for AGBL2 Gene

This gene is overexpressed in Testis (x15.4).

Protein differential expression in normal tissues from HIPED for AGBL2 Gene

This gene is overexpressed in Liver, secretome (45.7) and Tlymphocyte (22.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for AGBL2 Gene



Protein tissue co-expression partners for AGBL2 Gene

NURSA nuclear receptor signaling pathways regulating expression of AGBL2 Gene:

AGBL2

SOURCE GeneReport for Unigene cluster for AGBL2 Gene:

Hs.147377
genes like me logo Genes that share expression patterns with AGBL2: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and mRNA Expression by UniProt/SwissProt for AGBL2 Gene

Orthologs for AGBL2 Gene

This gene was present in the common ancestor of animals.

Orthologs for AGBL2 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia AGBL2 34 35
  • 99.59 (n)
dog
(Canis familiaris)
Mammalia AGBL2 34 35
  • 88.23 (n)
mouse
(Mus musculus)
Mammalia Agbl2 34 16 35
  • 83.55 (n)
rat
(Rattus norvegicus)
Mammalia Agbl2 34
  • 82.39 (n)
platypus
(Ornithorhynchus anatinus)
Mammalia AGBL2 35
  • 67 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia AGBL2 35
  • 59 (a)
OneToOne
chicken
(Gallus gallus)
Aves AGBL2 34 35
  • 63.55 (n)
lizard
(Anolis carolinensis)
Reptilia AGBL2 35
  • 60 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia agbl2 34
  • 63.4 (n)
Str.18052 34
zebrafish
(Danio rerio)
Actinopterygii agbl2 34 35
  • 62.28 (n)
fruit fly
(Drosophila melanogaster)
Insecta NnaD 35
  • 25 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea -- 35
  • 61 (a)
OneToMany
Species where no ortholog for AGBL2 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • cow (Bos Taurus)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for AGBL2 Gene

ENSEMBL:
Gene Tree for AGBL2 (if available)
TreeFam:
Gene Tree for AGBL2 (if available)

Paralogs for AGBL2 Gene

Paralogs for AGBL2 Gene

(2) SIMAP similar genes for AGBL2 Gene using alignment to 9 proteins:

genes like me logo Genes that share paralogs with AGBL2: view

Variants for AGBL2 Gene

Sequence variations from dbSNP and Humsavar for AGBL2 Gene

SNP ID Clin Chr 11 pos Sequence Context AA Info Type
rs10128705 -- 47,678,331(+) tttta(C/T)tttat intron-variant
rs1017730 -- 47,711,942(-) gccag(C/T)acacc intron-variant, upstream-variant-2KB
rs1017731 -- 47,716,253(+) TAGGT(A/C)AAATA intron-variant, downstream-variant-500B, upstream-variant-2KB
rs1023895 -- 47,717,382(+) ACACA(A/C)AACAC nc-transcript-variant, upstream-variant-2KB, utr-variant-3-prime
rs10400218 -- 47,679,098(+) AAGAC(A/C)CCTGA intron-variant

Structural Variations from Database of Genomic Variants (DGV) for AGBL2 Gene

Variant ID Type Subtype PubMed ID
nsv832143 CNV loss 17160897
nsv832142 CNV loss 17160897
nsv509405 CNV insertion 20534489
nsv481132 CNV novel sequence insertion 20440878
nsv469858 CNV gain 16826518
nsv315 CNV insertion 18451855
esv3407993 CNV insertion 20981092
dgv1111n100 CNV gain 25217958

Variation tolerance for AGBL2 Gene

Residual Variation Intolerance Score: 20% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 3.87; 58.95% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for AGBL2 Gene

Human Gene Mutation Database (HGMD)
AGBL2
SNPedia medical, phenotypic, and genealogical associations of SNPs for
AGBL2

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for AGBL2 Gene

Disorders for AGBL2 Gene

MalaCards: The human disease database

(2) MalaCards diseases for AGBL2 Gene - From: DISEASES

Disorder Aliases PubMed IDs
dyskinesia of esophagus
  • dyskinesia of oesophagus
bone inflammation disease
  • bone inflammatory disease
- elite association - COSMIC cancer census association via MalaCards
Search AGBL2 in MalaCards View complete list of genes associated with diseases

Relevant External Links for AGBL2

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
AGBL2
genes like me logo Genes that share disorders with AGBL2: view

No data available for UniProtKB/Swiss-Prot and Genatlas for AGBL2 Gene

Publications for AGBL2 Gene

  1. Tumor suppressor RARRES1 interacts with cytoplasmic carboxypeptidase AGBL2 to regulate the I+-tubulin tyrosination cycle. (PMID: 21303978) Sahab Z.J. … Byers S.W. (Cancer Res. 2011) 2 3 4 64
  2. Functional segregation and emerging role of cilia-related cytosolic carboxypeptidases (CCPs). (PMID: 23085998) Rodriguez de la Vega Otazo M. … Bautista J.M. (FASEB J. 2013) 3 4 64
  3. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4 64
  4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4 64
  5. Identification of candidate liver tumor suppressor genes from human 11p11.2 by transcription mapping of microcell hybrid cell lines. (PMID: 12738998) Jahn J.E. … Coleman W.B. (Int. J. Oncol. 2003) 2 3 64

Products for AGBL2 Gene

Sources for AGBL2 Gene

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