AGAP8 Gene
protein-coding GIFtS: 37
GCID: GC10M051224
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ArfGAP with GTPase domain, ankyrin repeat and PH domain...(Previous names: centaurin, gamma-like family, member 5 )
(Previous symbol: CTGLF5)
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Aliases
for AGAP8 gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| ArfGAP With GTPase Domain, Ankyrin Repeat And PH Domain 81 2 | | CTGLF51 2 3 | | Centaurin, Gamma-Like Family, Member 51 2 | | Centaurin-Gamma-Like Family Member 52 3 | | AGAP-82 3 | | Arf-GAP With GTPase, ANK Repeat And PH Domain-Containing Protein 82 |
Export aliases for AGAP8 gene to outside databasesPrevious GC identifer: GC10M050897 |
Summaries
for AGAP8 gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
UniProtKB/Swiss-Prot: AGAP8_HUMAN, Q5SRD3Function: Putative GTPase-activating protein (Potential)
|
Genomic Views
for AGAP8 gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000010.10 NC_018921.1 NT_030059.13
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the AGAP8 gene promoter:
AML1a Tal-1beta FOXL1 FOXJ2 (long isoform) HFH-1 FOXJ2 Pax-4a ITF-2
Other transcription factors
Search SABiosciences Chromatin IP Primers for AGAP8
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat AGAP8 |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 10q11.23 Ensembl cytogenetic band: 10q11.23 HGNC cytogenetic band: 10q11.23AGAP8 Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 10 GeneLoc Exon Structure GeneLoc location for GC10M051224: view genomic region
(about GC identifiers)
Start:
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51,224,688 bp from pter |
End:
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51,252,947 bp from pter |
Size:
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28,260 bases |
Orientation:
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minus strand |
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Proteins
for AGAP8 gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: AGAP8_HUMAN, Q5SRD3 (See
protein sequence)Recommended Name: Arf-GAP with GTPase, ANK repeat and PH domain-containing protein 8 Size: 663 amino acids; 73068 Da
Miscellaneous: Encoded by one of the numerous copies of centaurin gamma-like genes clustered in the q11 region ofchromosome 10Explore the universe of human proteins at neXtProt for AGAP8: NX_Q5SRD3
Post-translational modifications:
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_Q5SRD3
AGAP8 Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins (3 alternative transcripts):
NP_001071154.1 NP_001263272.1 NP_001263273.1
ENSEMBL proteins: ENSP00000415452
Human Recombinant Protein Products for AGAP8:
AGAP8 Antibody Products:
Assay Products for AGAP8: |
Protein
Domains /
Families
for AGAP8 gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
AGAP8 for domains About GeneDecksing
5 InterPro domains/families:Graphical View of Domain Structure for InterPro Entry Q5SRD3ProtoNet protein and cluster: Q5SRD3 1 Blocks protein family: IPB001164 HIV Rev interacting protein signature
UniProtKB/Swiss-Prot: AGAP8_HUMAN, Q5SRD3Similarity: Belongs to the centaurin gamma-like familySimilarity: Contains 2 ANK repeatsSimilarity: Contains 1 Arf-GAP domainSimilarity: Contains 1 PH domain |
Function
for AGAP8 gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
inGenious Targeting Laboratory,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase,
shRNA from
OriGene,
Sirion Biotech,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Sirion Biotech,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
Sirion Biotech,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Molecular Function:
UniProtKB/Swiss-Prot Summary: AGAP8_HUMAN, Q5SRD3Function: Putative GTPase-activating protein (Potential) Gene Ontology (GO): 3 molecular function terms (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0005543 | phospholipid binding |
IEA | -- | | GO:0008060 | ARF GTPase activator activity |
IEA | -- | | GO:0008270 | zinc ion binding |
IEA | -- |
AGAP8 for ontologies About GeneDecksing
Animal Models:
Clone
Products: |  | Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore | |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for AGAP8
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for AGAP8
OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
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| |  | GenScript: all cDNA clones in your preferred vector: AGAP8 (NM_001077686) | |  | Browse Sino Biological Human cDNA Clones | |  | DNA2.0 Custom Codon Optimized Gene
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In Situ Assay
Products: |
 | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for AGAP8 |
|
Pathways & Interactions
for AGAP8 gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Interactions:
Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for AGAP8
Gene Ontology (GO): 1 biological process term (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0032312 | regulation of ARF GTPase activity |
IEA | -- |
AGAP8 for ontologies About GeneDecksing
|
Drugs & Compounds
for AGAP8 gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
 Browse Tocris compounds for AGAP8
Search CenterWatch for drugs/clinical trials and news about AGAP8
|
Transcripts
for AGAP8 gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
Sirion Biotech,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for AGAP8 gene (3 alternative transcripts): NM_001077686.2 NM_001276343.1 NM_001276344.1 Unigene Cluster for AGAP8: ArfGAP with GTPase domain, ankyrin repeat and PH domain 8 Hs.536192 [show with all ESTs]Unigene Representative Sequence: NM_0010776865 Ensembl transcripts including schematic representations, and UCSC links where relevant: ENST00000425119(uc010qgy.2 uc001jij.3 uc021pqg.1 uc009xom.3 uc001jik.3)
ENST00000479304 ENST00000470172 ENST00000484805 ENST00000482521
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for AGAP8
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for AGAP8
OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript: all cDNA clones in your preferred vector: AGAP8 (NM_001077686) | | | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for AGAP8 | | | Search Vector BioLabs for ready-to-use adenovirus/AAV for human, mouse, rat AGAP8 |
8 DOTS entries: DT.445244 DT.92443635 DT.121289186 DT.102828606 DT.102840041 DT.101973107 DT.101979838 DT.95274220
GeneLoc Exon Structure
5/8 Alternative Splicing Database (ASD) splice patterns (SP) for AGAP8 (see all 8) About this scheme
| ExUns: | 1a | · | 1b | · | 1c | · | 1d | ^ | 2 | ^ | 3a | · | 3b | ^ | 4 | ^ | 5 | ^ | 6 | ^ | 7a | · | 7b | ^ | 8 | ^ | 9a | · | 9b | ^ | 10 | ^ | 11 | ^ | 12a | · | 12b | ^ | 13 | ^ | 14 | ^ | 15 | ^ | 16 |
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| SP1: | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | |
| SP2: | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | |
| SP3: | | | | | | | | | - | | - | | - | | - | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | |
| SP4: | | | | | | | - | | - | | - | | - | | | | - | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | |
| SP5: | | | | | | | | | - | | - | | - | | - | | - | | - | | - | | - | | | | | | | | | | | | | | | | | | | | | | | |
ECgene alternative splicing isoforms for AGAP8
|
Expression
for AGAP8 gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| AGAP8 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: --
About this image
See AGAP8 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for AGAP8
SOURCE GeneReport for Unigene cluster: Hs.536192
SABiosciences Custom PCR Arrays for AGAP8
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for AGAP8
Browse OriGene validated miRNA SYBR primer pairs
| | | SABiosciences RT2 qPCR Primer Assay in human, mouse / rat AGAP8 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat AGAP8 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat AGAP8 | In Situ
Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for AGAP8 |
Orthologs
for AGAP8 gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
This gene was present in the common ancestor of animals.
Orthologs for AGAP8 gene from 4/17 species (see all 17) About this table
ENSEMBL Gene Tree for AGAP8 (if available)
TreeFam Gene Tree for AGAP8 (if available) |
Paralogs
for AGAP8 gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| Paralogs for AGAP8 gene
- AGAP41 2 AGAP61 2 AGAP71 2 AGAP51 2 AGAP101 2 AGAP91 2 AGAP11 ASAP12
- ACAP22 ARAP32 GIT22 ACAP32 ARAP12 ASAP22 AGAP32 GIT12
- ARAP22 AGAP22 AGAP12 ACAP12 ASAP32
18/19 SIMAP similar genes for AGAP8 using alignment to 2 protein entries: AGAP8_HUMAN (see all proteins)
(see all similar genes):AGAP4 AGAP6 AGAP7 AGAP5 CENTG2 CTGLF11P
AGAP11 FLJ00312 AGAP10 AGAP9 AGAP1 DKFZp761E2216
AGAP3 CCNYL2 CENTG3 CCNYL1 AGAP2 ARFGAP1
AGAP8 for paralogs About GeneDecksing
1 Pseudogenes.org Pseudogene for AGAP8
PGOHUM00000238473
|
Genomic Variants
for AGAP8 gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr 10 pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
|---|
HapMap Linkage Disequilibrium report for AGAP8 (51224688 - 51252947 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 6 variations for AGAP8
6 CNVs: 3800 85264 6871 75241 31732 71007 | SABiosciences Cancer Mutation PCR Assays |
|
Disorders
/ Diseases
for AGAP8 gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
AGAP8 for disorders About GeneDecksing
1  disease for AGAP8: About MalaCardsmalaria
Export disorders for AGAP8 gene to outside databases
|
Publications
for AGAP8 gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for AGAP8 gene integrated from 9 sources:
(articles sorted by number of sources associating them with AGAP8) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- Exome sequencing identifies frequent mutation of the SWI/SNF complex gene PBRM1 in renal carcinoma. (PubMed id 21248752)2 Varela I....Futreal P.A. (2011)
- The DNA sequence and comparative analysis of human chromosome 10. (PubMed id 15164054)2 Deloukas P.... Rogers J. (2004)
- Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (2002)
|
External Searches for AGAP8 gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
|
|
Genome Databases showing AGAP8 gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing AGAP8 gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing AGAP8 gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
| Name | Description |
| PharmGKB entry for AGAP8 | Pharmacogenomics, SNPs, Pathways |
|
| | |
About This Section
| Patent Information for AGAP8 gene:
Search GeneIP for patents involving AGAP8
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for AGAP8 gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0 and Sirion Biotech, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript, LifeMap BioReagents, and Sirion Biotech, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences, In Situ Hybridization Assays from
Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory)
About This Section
|
 | |
 | |
 |
| | |  | Browse OriGene Antibodies | | OriGene shRNA RFP for AGAP8 | | | OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for AGAP8 | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for AGAP8 | | | OriGene Protein Over-expression Lysate for AGAP8 | | Browse OriGene Fluorogenic Cell Assay Kits | | | OriGene siRNA for AGAP8 | | OriGene 3'-UTR Clone for AGAP8 | | | OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for AGAP8 | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for AGAP8 | | | Browse OriGene GFP tagged cDNA clones in CMV expression vector | | Browse OriGene MicroRNA Expression Plasmids | | | Browse OriGene basic RS shRNAs | | Browse OriGene validated miRNA SYBR primer pairs | | | Browse OriGene full length recombinant human proteins expressed in human HEK293 cells | | OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
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| |
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 | | | AGAP8 Proteins, Antibodies, CLIAs, and ELISAs |
| | | | | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for AGAP8 |
|  |  |  |  | | | | Search ThermoFisher Antibodies for AGAP8 |
| | | Search Vector BioLabs for ready-to-use adenovirus/AAV for human, mouse, rat AGAP8 |
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