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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

AGAP6 Gene

protein-coding   GIFtS: 32
GCID: GC10P051748

ArfGAP With GTPase Domain, Ankyrin Repeat And PH Domain...

(Previous names: centaurin, gamma-like family, member 3)
(Previous symbol: CTGLF3)
  Search for AGAP6
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
ArfGAP With GTPase Domain, Ankyrin Repeat And PH Domain 61 2     AGAP-62 3
CTGLF31 2 3     Arf-GAP With GTPase, ANK Repeat And PH Domain-Containing Protein 62
Centaurin, Gamma-Like Family, Member 31 2     bA324H6.12
Centaurin-Gamma-Like Family Member 32 3     

External Ids:    HGNC: 234661   Entrez Gene: 4141892   Ensembl: ENSG000002041497   UniProtKB: Q5VW223   

Export aliases for AGAP6 gene to outside databases

Previous GC identifer: GC10P051420


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

GeneCards Summary for AGAP6 Gene: 
AGAP6 (ArfGAP with GTPase domain, ankyrin repeat and PH domain 6) is a protein-coding gene. GO annotations related to this gene include phospholipid binding and ARF GTPase activator activity. An important paralog of this gene is AGAP5.

UniProtKB/Swiss-Prot: AGAP6_HUMAN, Q5VW22
Function: Putative GTPase-activating protein (Potential)




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000010.10  NT_030059.13  NC_018921.2  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the AGAP6 gene promoter:
         AML1a   HFH-1   FOXJ2 (long isoform)   FOXJ2   Tal-1beta   Pax-4a   FOXL1   
         Other transcription factors

Browse SwitchGear Promoter luciferase reporter plasmids
   Search SABiosciences Chromatin IP Primers for AGAP6

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat AGAP6


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 10q11.23   Ensembl cytogenetic band:  10q11.23   HGNC cytogenetic band: 10q11.23

AGAP6 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
AGAP6 gene location

GeneLoc information about chromosome 10         GeneLoc Exon Structure

GeneLoc location for GC10P051748:  view genomic region     (about GC identifiers)

Start:
51,748,078 bp from pter      End:
51,770,259 bp from pter
Size:
22,182 bases      Orientation:
plus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
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About This Section

UniProtKB/Swiss-Prot: AGAP6_HUMAN, Q5VW22 (See protein sequence)
Recommended Name: Arf-GAP with GTPase, ANK repeat and PH domain-containing protein 6  
Size: 663 amino acids; 73127 Da
Miscellaneous: Encoded by one of the numerous copies of centaurin gamma-like genes clustered in the q11 region of
chromosome 10
Sequence caution: Sequence=BC131545; Type=Frameshift; Positions=Several;
Alternative splicing: 2 isoforms:  Q5VW22-1   Q5VW22-2   (Prediction based on family homologs sequence)

Explore the universe of human proteins at neXtProt for AGAP6: NX_Q5VW22

Explore proteomics data for AGAP6 at MOPED 

Post-translational modifications:

  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_Q5VW22

  • AGAP6 Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    AGAP6 Protein Expression
    REFSEQ proteins: NP_001071133.2  
    ENSEMBL proteins: 
     ENSP00000400972   ENSP00000363168  

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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    HGNC Gene Families: 
    PLEKH: Pleckstrin homology (PH) domain containing
    ANKRD: Ankyrin repeat domain containing
    ArfGAP: ADP-ribosylation factor GTPase activating proteins

    5 InterPro protein domains:
     IPR001849 Pleckstrin_homology
     IPR001164 ArfGAP
     IPR020683 Ankyrin_rpt-contain_dom
     IPR011993 PH_like_dom
     IPR002110 Ankyrin_rpt

    Graphical View of Domain Structure for InterPro Entry Q5VW22

    ProtoNet protein and cluster: Q5VW22

    1 Blocks protein domain: IPB001164 HIV Rev interacting protein signature

    UniProtKB/Swiss-Prot: AGAP6_HUMAN, Q5VW22
    Similarity: Belongs to the centaurin gamma-like family
    Similarity: Contains 2 ANK repeats
    Similarity: Contains 1 Arf-GAP domain
    Similarity: Contains 1 PH domain


    AGAP6 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: AGAP6_HUMAN, Q5VW22
    Function: Putative GTPase-activating protein (Potential)

         Gene Ontology (GO): 4 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005515protein binding ----
    GO:0005543phospholipid binding IEA--
    GO:0008060ARF GTPase activator activity IEA--
    GO:0008270zinc ion binding IEA--
         
    AGAP6 for ontologies           About GeneDecksing


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    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section



    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for AGAP6

    Gene Ontology (GO): 1 biological process term (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0032312regulation of ARF GTPase activity IEA--

    AGAP6 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
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    Browse Tocris compounds for AGAP6

    Search CenterWatch for drugs/clinical trials and news about AGAP6

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
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    About This Section

    REFSEQ mRNAs for AGAP6 gene: 
    NM_001077665.2  

    Unigene Cluster for AGAP6:

    ArfGAP with GTPase domain, ankyrin repeat and PH domain 6
    Hs.536158  [show with all ESTs]
    Unigene Representative Sequence: NM_001077665
    2 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000412531 ENST00000374056(uc001jix.4)
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    Additional mRNA sequence: BC131545.1 

    7 DOTS entries:

    DT.102828606  DT.86856013  DT.121250606  DT.102842747  DT.101979838  DT.102840041  DT.121288881 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    AGAP6 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: --
    AGAP6 Expression
    About this image


    See AGAP6 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for AGAP6

    SOURCE GeneReport for Unigene cluster: Hs.536158
        SABiosciences Custom PCR Arrays for AGAP6
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    In Situ
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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of animals.

    Orthologs for AGAP6 gene from 5/12 species (see all 12)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    chicken
    (Gallus gallus)
    Aves AGAP16
    Uncharacterized protein
    53(a)
    possible ortholog
    7(5139160-5321453)
    lizard
    (Anolis carolinensis)
    Reptilia AGAP16
    --
    --
    62(a)
    6(a)
    possible ortholog
    possible ortholog
    1(119629499-119789786)
    1(119461547-119529618)
    zebrafish
    (Danio rerio)
    Actinopterygii AGAP16
    Uncharacterized protein
    43(a)
    1 → many
    6(15961367-16311293)
    fruit fly
    (Drosophila melanogaster)
    Insecta cenG1A6
    centaurin gamma 1A
    23(a)
    1 → many
    2L(13835567-13898715)
    worm
    (Caenorhabditis elegans)
    Secernentea cnt-26
    Protein CNT-2, isoform b
    17(a)
    1 → many
    III(10655770-10677522)
            Species with no ortholog for AGAP6

    ENSEMBL Gene Tree for AGAP6 (if available)
    TreeFam Gene Tree for AGAP6 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for AGAP6 gene
    AGAP81 2  AGAP41 2  AGAP71 2  AGAP51 2  AGAP101 2  AGAP91 2  AGAP11  ASAP12  
    ARAP32  ACAP22  ACAP32  ASAP22  ARAP12  AGAP32  ARAP22  AGAP22  
    AGAP12  ACAP12  ASAP32  
    15 SIMAP similar genes for AGAP6 using alignment to 1 protein entry:     AGAP6_HUMAN:
    AGAP4    AGAP7    AGAP8    AGAP5    CENTG2    CTGLF11P
    AGAP11    FLJ00312    AGAP10    AGAP9    AGAP1    DKFZp761E2216
    AGAP3    CENTG3    AGAP2

    AGAP6 for paralogs           About GeneDecksing


    1 Pseudogenes.org Pseudogene for AGAP6
    PGOHUM00000238733


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/288 SNPs in AGAP6 are shown (see all 288)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 10 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1931943511,2
    --51746225(+) TAAAAC/GGTTAA 1 -- us2k10--------
    rs2011803851,2
    --51746339(+) CTCAA-/AATAAT
            
    AATAA
    1 -- cds10--------
    rs31218691,2
    --51746346(+) ATAATA/CATCAT 1 -- us2k10--------
    rs1829877511,2
    --51746412(+) ACTTCC/TACCTT 1 -- us2k10--------
    rs1869929551,2
    --51746849(+) TTGGCC/TTCCCA 1 -- us2k10--------
    rs1918194801,2
    --51747145(+) GCTATA/GCTTTC 1 -- us2k10--------
    rs169308251,2
    F--51747254(+) TTCTCC/TGTCTC 1 -- us2k11Minor allele frequency- T:0.49MN 184
    rs1160889461,2
    F--51747419(+) TTGTGT/CATGAG 1 -- us2k11Minor allele frequency- C:0.01WA 118
    rs2002840791,2
    C--51748266(+) AACTC-/AGGGGAG 1 -- ut510--------
    rs1836690041,2
    C--51748309(+) TAGCCA/GGGGCC 1 -- ut510--------

    HapMap Linkage Disequilibrium report for AGAP6 (51748078 - 51770259 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 8 variations for AGAP6:    About this table     
    Variant IDTypeSubtypePubMed ID
    nsv8655CNV Loss18304495
    nsv895383CNV Loss21882294
    esv26750CNV Loss19812545
    nsv895389CNV Gain21882294
    nsv518071CNV Gain19592680
    nsv428232CNV Gain+Loss18775914
    essv19403CNV CNV17122850
    dgv273e1CNV Complex17122850

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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
      --

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for AGAP6 gene integrated from 9 sources:
    (articles sorted by number of sources associating them with AGAP6)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. The DNA sequence and comparative analysis of human chromosome 10. (PubMed id 15164054)2 Deloukas P.... Rogers J. (2004)
    2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)2 Gerhard D.S....Malek J. (2004)
    3. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (2002)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 414189 HGNC: 23466 Ensembl:ENSG00000204149 euGenes: HUgn414189 ECgene: AGAP6
    H-InvDB: AGAP6

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for AGAP6 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for AGAP6 gene:
    Search GeneIP for patents involving AGAP6

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0 and Sirion Biotech, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Sirion Biotech, Cell lines from GenScript, and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
    About This Section

     
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    GeneCards Homepage - Last full update: 23 Oct 2013 - Incrementals: 4 Nov 2013 , 7 Nov 2013 , 23 Jan 2014

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    (GIFtS: 73)
    transforming growth factor, beta 1
    GIFtS Group
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