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Aliases for AGAP5 Gene

Aliases for AGAP5 Gene

  • ArfGAP With GTPase Domain, Ankyrin Repeat And PH Domain 5 2 3 5
  • Centaurin, Gamma-Like Family, Member 2 2 3
  • Centaurin-Gamma-Like Family Member 2 3 4
  • CTGLF2 3 4
  • AGAP-5 3 4
  • Arf-GAP With GTPase, ANK Repeat And PH Domain-Containing Protein 5 3

External Ids for AGAP5 Gene

Previous HGNC Symbols for AGAP5 Gene

  • CTGLF2

Previous GeneCards Identifiers for AGAP5 Gene

  • GC10M075108
  • GC10M075435

Summaries for AGAP5 Gene

GeneCards Summary for AGAP5 Gene

AGAP5 (ArfGAP With GTPase Domain, Ankyrin Repeat And PH Domain 5) is a Protein Coding gene. GO annotations related to this gene include GTPase activator activity. An important paralog of this gene is AGAP14.

UniProtKB/Swiss-Prot for AGAP5 Gene

  • Putative GTPase-activating protein.

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for AGAP5 Gene

Genomics for AGAP5 Gene

Regulatory Elements for AGAP5 Gene

Enhancers for AGAP5 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
- Elite enhancer/Elite enhancer-gene association

Enhancers around AGAP5 on UCSC Golden Path with GeneCards custom track

Genomic Location for AGAP5 Gene

73,674,275 bp from pter
73,698,159 bp from pter
23,885 bases
Minus strand

Genomic View for AGAP5 Gene

Genes around AGAP5 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
AGAP5 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for AGAP5 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for AGAP5 Gene

Proteins for AGAP5 Gene

  • Protein details for AGAP5 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Arf-GAP with GTPase, ANK repeat and PH domain-containing protein 5
    Protein Accession:
    Secondary Accessions:
    • A8MSN5

    Protein attributes for AGAP5 Gene

    686 amino acids
    Molecular mass:
    75492 Da
    Quaternary structure:
    No Data Available
    • Encoded by one of the numerous copies of centaurin gamma-like genes clustered in the q11 region of chromosome 10.

neXtProt entry for AGAP5 Gene

Post-translational modifications for AGAP5 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for AGAP5 Gene

No data available for DME Specific Peptides for AGAP5 Gene

Domains & Families for AGAP5 Gene

Protein Domains for AGAP5 Gene

Suggested Antigen Peptide Sequences for AGAP5 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Contains 1 Arf-GAP domain.
  • Belongs to the centaurin gamma-like family.
  • Contains 2 ANK repeats.
  • Contains 1 Arf-GAP domain.
  • Contains 1 PH domain.
  • Belongs to the centaurin gamma-like family.
  • Contains 2 ANK repeats.
genes like me logo Genes that share domains with AGAP5: view

Function for AGAP5 Gene

Molecular function for AGAP5 Gene

UniProtKB/Swiss-Prot Function:
Putative GTPase-activating protein.

Gene Ontology (GO) - Molecular Function for AGAP5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005096 GTPase activator activity IEA --
GO:0046872 metal ion binding IEA --
genes like me logo Genes that share ontologies with AGAP5: view

Phenotypes for AGAP5 Gene

genes like me logo Genes that share phenotypes with AGAP5: view

Animal Model Products

CRISPR Products

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for AGAP5 Gene

Localization for AGAP5 Gene

Subcellular locations from

Jensen Localization Image for AGAP5 Gene COMPARTMENTS Subcellular localization image for AGAP5 gene
Compartment Confidence
cytosol 3
extracellular 2
nucleus 2

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Gene Ontology (GO) - Cellular Components for AGAP5 Gene

Pathways & Interactions for AGAP5 Gene

SuperPathways for AGAP5 Gene

No Data Available

Interacting Proteins for AGAP5 Gene

Gene Ontology (GO) - Biological Process for AGAP5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0043547 positive regulation of GTPase activity IEA --
genes like me logo Genes that share ontologies with AGAP5: view

No data available for Pathways by source and SIGNOR curated interactions for AGAP5 Gene

Drugs & Compounds for AGAP5 Gene

No Compound Related Data Available

Transcripts for AGAP5 Gene

mRNA/cDNA for AGAP5 Gene

(6) REFSEQ mRNAs :
(0) Additional mRNA sequences :
(4) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for AGAP5 Gene

ArfGAP with GTPase domain, ankyrin repeat and PH domain 5:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for AGAP5 Gene

No ASD Table

Relevant External Links for AGAP5 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for AGAP5 Gene

mRNA expression in normal human tissues for AGAP5 Gene

Protein differential expression in normal tissues from HIPED for AGAP5 Gene

This gene is overexpressed in Brain (69.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for AGAP5 Gene

Protein tissue co-expression partners for AGAP5 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of AGAP5 Gene:


SOURCE GeneReport for Unigene cluster for AGAP5 Gene:

genes like me logo Genes that share expression patterns with AGAP5: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for AGAP5 Gene

Orthologs for AGAP5 Gene

This gene was present in the common ancestor of animals.

Orthologs for AGAP5 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia CTGLF2 34
  • 98.34 (n)
  • 96.44 (a)
(Monodelphis domestica)
Mammalia -- 35
  • 74 (a)
(Ornithorhynchus anatinus)
Mammalia -- 35
  • 46 (a)
(Gallus gallus)
Aves -- 35
  • 58 (a)
(Anolis carolinensis)
Reptilia -- 35
  • 13 (a)
-- 35
  • 63 (a)
(Danio rerio)
Actinopterygii agap1 35
  • 48 (a)
fruit fly
(Drosophila melanogaster)
Insecta cenG1A 35
  • 26 (a)
(Caenorhabditis elegans)
Secernentea cnt-2 35
  • 20 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 35
  • 35 (a)
Species where no ortholog for AGAP5 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • cow (Bos Taurus)
  • dog (Canis familiaris)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • mouse (Mus musculus)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)

Evolution for AGAP5 Gene

Gene Tree for AGAP5 (if available)
Gene Tree for AGAP5 (if available)

Paralogs for AGAP5 Gene

(16) SIMAP similar genes for AGAP5 Gene using alignment to 3 proteins: Pseudogenes for AGAP5 Gene

genes like me logo Genes that share paralogs with AGAP5: view

Variants for AGAP5 Gene

Sequence variations from dbSNP and Humsavar for AGAP5 Gene

SNP ID Clin Chr 10 pos Sequence Context AA Info Type
rs3861034 -- 73,676,088(-) CTCCT(C/T)CTGTT intron-variant
rs3861035 -- 73,676,314(-) ttttt(C/T)ttttc intron-variant
rs3861036 -- 73,676,347(+) tggtg(G/T)cacat intron-variant
rs3870388 -- 73,676,002(-) TTCCA(C/T)CGACT reference, missense
rs3870389 -- 73,676,048(-) AAGAA(A/C)AGAAA reference, missense

Structural Variations from Database of Genomic Variants (DGV) for AGAP5 Gene

Variant ID Type Subtype PubMed ID
esv24583 CNV loss 19812545
nsv831912 CNV gain 17160897
nsv8688 CNV loss 18304495
nsv948068 CNV duplication 23825009
nsv971764 CNV duplication 23825009
nsv971766 CNV duplication 23825009
nsv974949 CNV duplication 23825009
nsv975705 CNV duplication 23825009

Variation tolerance for AGAP5 Gene

Gene Damage Index Score: 4.04; 60.51% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for AGAP5 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for AGAP5 Gene

Disorders for AGAP5 Gene

Relevant External Links for AGAP5

Atlas of Genetics and Cytogenetics in Oncology and Haematology:

No disorders were found for AGAP5 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for AGAP5 Gene

Publications for AGAP5 Gene

  1. The functional landscape of Hsp27 reveals new cellular processes such as DNA repair and alternative splicing and proposes novel anticancer targets. (PMID: 25277244) Katsogiannou M. … Rocchi P. (Mol. Cell Proteomics 2014) 3 65
  2. The DNA sequence and comparative analysis of human chromosome 10. (PMID: 15164054) Deloukas P. … Rogers J. (Nature 2004) 4 65
  3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 4 65
  4. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg R.L. … Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002) 3 65

Products for AGAP5 Gene

Sources for AGAP5 Gene

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