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Aliases for AGAP5 Gene

Aliases for AGAP5 Gene

  • ArfGAP With GTPase Domain, Ankyrin Repeat And PH Domain 5 2 3
  • Centaurin, Gamma-Like Family, Member 2 2 3
  • Centaurin-Gamma-Like Family Member 2 3 4
  • CTGLF2 3 4
  • AGAP-5 3 4
  • Arf-GAP With GTPase, ANK Repeat And PH Domain-Containing Protein 5 3

External Ids for AGAP5 Gene

Previous Symbols for AGAP5 Gene

  • CTGLF2

Summaries for AGAP5 Gene

GeneCards Summary for AGAP5 Gene

AGAP5 (ArfGAP With GTPase Domain, Ankyrin Repeat And PH Domain 5) is a Protein Coding gene. GO annotations related to this gene include phospholipid binding. An important paralog of this gene is ASAP3.

UniProtKB/Swiss-Prot for AGAP5 Gene

  • Putative GTPase-activating protein.

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for AGAP5 Gene

Genomics for AGAP5 Gene

Genomic Location for AGAP5 Gene

Start:
73,674,275 bp from pter
End:
73,697,881 bp from pter
Size:
23,607 bases
Orientation:
Minus strand

Genomic View for AGAP5 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for AGAP5 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for AGAP5 Gene

Regulatory Elements for AGAP5 Gene

Proteins for AGAP5 Gene

  • Protein details for AGAP5 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    A6NIR3-AGAP5_HUMAN
    Recommended name:
    Arf-GAP with GTPase, ANK repeat and PH domain-containing protein 5
    Protein Accession:
    A6NIR3
    Secondary Accessions:
    • A8MSN5

    Protein attributes for AGAP5 Gene

    Size:
    686 amino acids
    Molecular mass:
    75492 Da
    Quaternary structure:
    No Data Available
    Miscellaneous:
    • Encoded by one of the numerous copies of centaurin gamma-like genes clustered in the q11 region of chromosome 10

neXtProt entry for AGAP5 Gene

Proteomics data for AGAP5 Gene at MOPED

Post-translational modifications for AGAP5 Gene

No Post-translational modifications

Other Protein References for AGAP5 Gene

No data available for DME Specific Peptides for AGAP5 Gene

Domains for AGAP5 Gene

Gene Families for AGAP5 Gene

HGNC:
  • PLEKH :Pleckstrin homology (PH) domain containing
  • ArfGAP :ADP-ribosylation factor GTPase activating proteins
  • ANKRD :Ankyrin repeat domain containing

Protein Domains for AGAP5 Gene

UniProtKB/Swiss-Prot:

AGAP5_HUMAN
Domain:
  • Contains 1 Arf-GAP domain.:
    • A6NIR3
  • Contains 1 PH domain.:
    • A6NIR3
Family:
  • Belongs to the centaurin gamma-like family.:
    • A6NIR3
Similarity:
  • Contains 2 ANK repeats.:
    • A6NIR3
genes like me logo Genes that share domains with AGAP5: view

Function for AGAP5 Gene

Molecular function for AGAP5 Gene

UniProtKB/Swiss-Prot Function: Putative GTPase-activating protein.

Gene Ontology (GO) - Molecular Function for AGAP5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005096 GTPase activator activity IEA --
GO:0005515 protein binding --
GO:0008270 zinc ion binding IEA --
genes like me logo Genes that share ontologies with AGAP5: view

No data available for Enzyme Numbers (IUBMB) , Phenotypes , Animal Models , miRNA , Transcription Factor Targeting and HOMER Transcription for AGAP5 Gene

Localization for AGAP5 Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for AGAP5 Gene COMPARTMENTS Subcellular localization image for AGAP5 gene
Compartment Confidence
cytosol 3
extracellular 2
nucleus 2

No data available for Gene Ontology (GO) - Cellular Components for AGAP5 Gene

Pathways for AGAP5 Gene

SuperPathways for AGAP5 Gene

No Data Available

Interacting Proteins for AGAP5 Gene

Gene Ontology (GO) - Biological Process for AGAP5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0043547 positive regulation of GTPase activity IEA --
genes like me logo Genes that share ontologies with AGAP5: view

No data available for Pathways by source for AGAP5 Gene

Transcripts for AGAP5 Gene

mRNA/cDNA for AGAP5 Gene

(1) REFSEQ mRNAs :
(0) Additional mRNA sequences :
(4) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for AGAP5 Gene

ArfGAP with GTPase domain, ankyrin repeat and PH domain 5:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for AGAP5 Gene

No ASD Table

Relevant External Links for AGAP5 Gene

GeneLoc Exon Structure for
AGAP5
ECgene alternative splicing isoforms for
AGAP5

Expression for AGAP5 Gene

mRNA expression in normal human tissues for AGAP5 Gene

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, and MOPED for AGAP5 Gene

SOURCE GeneReport for Unigene cluster for AGAP5 Gene Hs.651147

genes like me logo Genes that share expressions with AGAP5: view

Orthologs for AGAP5 Gene

This gene was present in the common ancestor of animals.

Orthologs for AGAP5 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia CTGLF2 36
  • 98.34 (n)
  • 96.44 (a)
oppossum
(Monodelphis domestica)
Mammalia -- 37
  • 74 (a)
OneToMany
platypus
(Ornithorhynchus anatinus)
Mammalia -- 37
  • 46 (a)
OneToMany
chicken
(Gallus gallus)
Aves -- 37
  • 58 (a)
OneToMany
lizard
(Anolis carolinensis)
Reptilia -- 37
  • 13 (a)
ManyToMany
-- 37
  • 63 (a)
ManyToMany
zebrafish
(Danio rerio)
Actinopterygii agap1 37
  • 48 (a)
OneToMany
fruit fly
(Drosophila melanogaster)
Insecta cenG1A 37
  • 26 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea cnt-2 37
  • 20 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea -- 37
  • 35 (a)
OneToMany
Species with no ortholog for AGAP5:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • cow (Bos Taurus)
  • dog (Canis familiaris)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • mouse (Mus musculus)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)

Evolution for AGAP5 Gene

ENSEMBL:
Gene Tree for AGAP5 (if available)
TreeFam:
Gene Tree for AGAP5 (if available)

Paralogs for AGAP5 Gene

Selected SIMAP similar genes for AGAP5 Gene using alignment to 3 proteins:

Pseudogenes.org Pseudogenes for AGAP5 Gene

genes like me logo Genes that share paralogs with AGAP5: view

Variants for AGAP5 Gene

Sequence variations from dbSNP and Humsavar for AGAP5 Gene

SNP ID Clin Chr 10 pos Sequence Context AA Info Type MAF
rs2394385 -- 73,688,922(+) GCACA(A/G)ctgcc intron-variant
rs3861036 -- 73,676,347(+) tggtg(G/T)cacat intron-variant
rs3878011 -- 73,676,694(+) AAATA(C/G)AACCT intron-variant
rs3878052 -- 73,694,192(-) GATGT(A/C)ATGTA intron-variant
rs3878053 -- 73,694,271(-) CGCAG(A/T)CCTCT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for AGAP5 Gene

Variant ID Type Subtype PubMed ID
nsv831912 CNV Gain 17160897
esv24583 CNV Loss 19812545
nsv8688 CNV Loss 18304495

Relevant External Links for AGAP5 Gene

HapMap Linkage Disequilibrium report
AGAP5

Disorders for AGAP5 Gene

No disorders were found for AGAP5 Gene.

No data available for UniProtKB/Swiss-Prot for AGAP5 Gene

Publications for AGAP5 Gene

  1. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg R.L. … Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002) 3
  2. The DNA sequence and comparative analysis of human chromosome 10. (PMID: 15164054) Deloukas P. … Rogers J. (Nature 2004) 4
  3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 4

Products for AGAP5 Gene

Sources for AGAP5 Gene

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