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Aliases for AGAP5 Gene

Aliases for AGAP5 Gene

  • ArfGAP With GTPase Domain, Ankyrin Repeat And PH Domain 5 2 3 5
  • Centaurin, Gamma-Like Family, Member 2 2 3
  • CTGLF2 3 4
  • AGAP-5 3 4
  • Arf-GAP With GTPase, ANK Repeat And PH Domain-Containing Protein 5 3
  • Centaurin-Gamma-Like Family Member 2 4

External Ids for AGAP5 Gene

Previous HGNC Symbols for AGAP5 Gene

  • CTGLF2

Previous GeneCards Identifiers for AGAP5 Gene

  • GC10M075108
  • GC10M075435

Summaries for AGAP5 Gene

GeneCards Summary for AGAP5 Gene

AGAP5 (ArfGAP With GTPase Domain, Ankyrin Repeat And PH Domain 5) is a Protein Coding gene. GO annotations related to this gene include GTPase activator activity. An important paralog of this gene is AGAP6.

UniProtKB/Swiss-Prot for AGAP5 Gene

  • Putative GTPase-activating protein.

Additional gene information for AGAP5 Gene

No data available for Entrez Gene Summary , CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for AGAP5 Gene

Genomics for AGAP5 Gene

Regulatory Elements for AGAP5 Gene

Enhancers for AGAP5 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH10H074417 2.7 VISTA Ensembl ENCODE 16.7 -720.5 -720464 1 PKNOX1 FEZF1 ZNF2 YY1 TSHZ1 ZNF610 ZSCAN16 GLIS1 HNF4A WT1 AGAP5 GLUD1P3 DUSP8P5 ENSG00000272791 ENSG00000272140 ZSWIM8 KAT6B ENSG00000268584 SEC24C ENSG00000227186
GH10H073930 1.2 Ensembl ENCODE 36.9 -232.6 -232649 1 HDGF PKNOX1 ATF1 ARNT TCF12 ATF7 CAVIN1 REST ZNF592 SNIP1 GLUD1P3 ECD ENSG00000272140 AGAP5 DUSP8P5 SEC24C ZSWIM8 KAT6B AP3M1 BMS1P4
GH10H073584 1.6 Ensembl ENCODE dbSUPER 26.8 +111.8 111819 2 PKNOX1 FOXA2 ARID4B FEZF1 DMAP1 ZNF2 YY1 ZNF766 CBX5 FOS ENSG00000272140 AGAP5 GLUD1P3 SEC24C NUDT13 DUSP8P5 ZSWIM8 BMS1P4 ZSWIM8-AS1 ENSG00000242288
GH10H073261 1.8 FANTOM5 Ensembl ENCODE dbSUPER 23.4 +435.7 435726 2 PKNOX1 ATF1 ARNT ATF7 FOS ZNF592 MEF2D ATF4 SMARCA4 MYNN NUDT13 GLUD1P3 DUSP8P5 AGAP5 ENSG00000272140 ECD ENSG00000224195 ENSG00000242288 CFAP70 RPL17P50
GH10H074174 1.7 Ensembl ENCODE dbSUPER 23.4 -478.9 -478880 5 HDGF PKNOX1 FOXA2 ARNT ARID4B SIN3A FEZF1 DMAP1 ZNF2 YY1 KAT6B ADK GLUD1P3 ENSG00000272791 DUSP8P5 AP3M1 AGAP5 ENSG00000272140 ENSG00000224195 ENSG00000242288
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around AGAP5 on UCSC Golden Path with GeneCards custom track

Genomic Location for AGAP5 Gene

Chromosome:
10
Start:
73,674,275 bp from pter
End:
73,698,159 bp from pter
Size:
23,885 bases
Orientation:
Minus strand

Genomic View for AGAP5 Gene

Genes around AGAP5 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
AGAP5 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for AGAP5 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for AGAP5 Gene

Proteins for AGAP5 Gene

  • Protein details for AGAP5 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    A6NIR3-AGAP5_HUMAN
    Recommended name:
    Arf-GAP with GTPase, ANK repeat and PH domain-containing protein 5
    Protein Accession:
    A6NIR3
    Secondary Accessions:
    • A8MSN5

    Protein attributes for AGAP5 Gene

    Size:
    686 amino acids
    Molecular mass:
    75492 Da
    Quaternary structure:
    No Data Available
    Miscellaneous:
    • Encoded by one of the numerous copies of centaurin gamma-like genes clustered in the q11 region of chromosome 10.

neXtProt entry for AGAP5 Gene

Post-translational modifications for AGAP5 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for AGAP5 Gene

Domains & Families for AGAP5 Gene

Protein Domains for AGAP5 Gene

Suggested Antigen Peptide Sequences for AGAP5 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

A6NIR3

UniProtKB/Swiss-Prot:

AGAP5_HUMAN :
  • Belongs to the centaurin gamma-like family.
Family:
  • Belongs to the centaurin gamma-like family.
genes like me logo Genes that share domains with AGAP5: view

Function for AGAP5 Gene

Molecular function for AGAP5 Gene

UniProtKB/Swiss-Prot Function:
Putative GTPase-activating protein.

Phenotypes From GWAS Catalog for AGAP5 Gene

Gene Ontology (GO) - Molecular Function for AGAP5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005096 GTPase activator activity IEA --
GO:0046872 metal ion binding IEA --
genes like me logo Genes that share ontologies with AGAP5: view

Phenotypes for AGAP5 Gene

genes like me logo Genes that share phenotypes with AGAP5: view

Animal Model Products

CRISPR Products

Inhibitory RNA Products

Clone Products

  • Applied Biological Materials Clones for AGAP5
  • Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for AGAP5 Gene

Localization for AGAP5 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for AGAP5 gene
Compartment Confidence
cytosol 3
extracellular 2
nucleus 2

No data available for Subcellular locations from UniProtKB/Swiss-Prot , Subcellular locations from the Human Protein Atlas (HPA) and Gene Ontology (GO) - Cellular Components for AGAP5 Gene

Pathways & Interactions for AGAP5 Gene

SuperPathways for AGAP5 Gene

No Data Available

Interacting Proteins for AGAP5 Gene

Gene Ontology (GO) - Biological Process for AGAP5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0043547 positive regulation of GTPase activity IEA --
genes like me logo Genes that share ontologies with AGAP5: view

No data available for Pathways by source and SIGNOR curated interactions for AGAP5 Gene

Drugs & Compounds for AGAP5 Gene

No Compound Related Data Available

Transcripts for AGAP5 Gene

mRNA/cDNA for AGAP5 Gene

(6) REFSEQ mRNAs :
(0) Additional mRNA sequences :
-
(4) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for AGAP5 Gene

ArfGAP with GTPase domain, ankyrin repeat and PH domain 5:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Clone Products

  • Applied Biological Materials Clones for AGAP5
  • Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more

Alternative Splicing Database (ASD) splice patterns (SP) for AGAP5 Gene

No ASD Table

Relevant External Links for AGAP5 Gene

GeneLoc Exon Structure for
AGAP5
ECgene alternative splicing isoforms for
AGAP5

Expression for AGAP5 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for AGAP5 Gene

Protein differential expression in normal tissues from HIPED for AGAP5 Gene

This gene is overexpressed in Brain (69.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for AGAP5 Gene



Protein tissue co-expression partners for AGAP5 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of AGAP5 Gene:

AGAP5

SOURCE GeneReport for Unigene cluster for AGAP5 Gene:

Hs.651147
genes like me logo Genes that share expression patterns with AGAP5: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for AGAP5 Gene

Orthologs for AGAP5 Gene

This gene was present in the common ancestor of animals.

Orthologs for AGAP5 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia CTGLF2 33
  • 98.34 (n)
oppossum
(Monodelphis domestica)
Mammalia -- 34
  • 74 (a)
OneToMany
platypus
(Ornithorhynchus anatinus)
Mammalia -- 34
  • 46 (a)
OneToMany
chicken
(Gallus gallus)
Aves -- 34
  • 58 (a)
OneToMany
lizard
(Anolis carolinensis)
Reptilia -- 34
  • 63 (a)
ManyToMany
-- 34
  • 13 (a)
ManyToMany
zebrafish
(Danio rerio)
Actinopterygii agap1 34
  • 48 (a)
OneToMany
fruit fly
(Drosophila melanogaster)
Insecta cenG1A 34
  • 26 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea cnt-2 34
  • 20 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea -- 34
  • 35 (a)
OneToMany
Species where no ortholog for AGAP5 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • cow (Bos Taurus)
  • dog (Canis familiaris)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • mouse (Mus musculus)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)

Evolution for AGAP5 Gene

ENSEMBL:
Gene Tree for AGAP5 (if available)
TreeFam:
Gene Tree for AGAP5 (if available)

Paralogs for AGAP5 Gene

(16) SIMAP similar genes for AGAP5 Gene using alignment to 3 proteins:

Pseudogenes.org Pseudogenes for AGAP5 Gene

genes like me logo Genes that share paralogs with AGAP5: view

Variants for AGAP5 Gene

Sequence variations from dbSNP and Humsavar for AGAP5 Gene

SNP ID Clin Chr 10 pos Sequence Context AA Info Type
rs1000104499 -- 73,699,673(+) TGCCC(C/T)CGTGA intron-variant, upstream-variant-2KB
rs1000346048 -- 73,688,047(+) AATCT(-/CTAA)CTAGA intron-variant
rs1000570137 -- 73,678,366(+) CTCGG(C/T)CTAAA intron-variant
rs1000581646 -- 73,677,788(+) GACAC(G/T)TGCCA intron-variant
rs1000837625 -- 73,687,778(+) AACCT(C/T)ATTAG intron-variant

Structural Variations from Database of Genomic Variants (DGV) for AGAP5 Gene

Variant ID Type Subtype PubMed ID
esv24583 CNV loss 19812545
nsv831912 CNV gain 17160897
nsv8688 CNV loss 18304495
nsv948068 CNV duplication 23825009
nsv971764 CNV duplication 23825009
nsv971766 CNV duplication 23825009
nsv974949 CNV duplication 23825009
nsv975705 CNV duplication 23825009

Variation tolerance for AGAP5 Gene

Gene Damage Index Score: 4.04; 60.51% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for AGAP5 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
AGAP5

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for AGAP5 Gene

Disorders for AGAP5 Gene

Relevant External Links for AGAP5

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
AGAP5

No disorders were found for AGAP5 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for AGAP5 Gene

Publications for AGAP5 Gene

  1. The functional landscape of Hsp27 reveals new cellular processes such as DNA repair and alternative splicing and proposes novel anticancer targets. (PMID: 25277244) Katsogiannou M … Rocchi P (Molecular & cellular proteomics : MCP 2014) 3 60
  2. The DNA sequence and comparative analysis of human chromosome 10. (PMID: 15164054) Deloukas P … Rogers J (Nature 2004) 4 60
  3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 4 60
  4. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg RL … Mammalian Gene Collection Program Team (Proceedings of the National Academy of Sciences of the United States of America 2002) 3 60

Products for AGAP5 Gene

Sources for AGAP5 Gene

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