AGAP4 Gene
protein-coding GIFtS: 41
GCID: GC10M046322
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ArfGAP with GTPase domain, ankyrin repeat and PH domain...(Previous names: centaurin, gamma-like family, member 1 )
(Previous symbol: CTGLF1)
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Aliases
for AGAP4 gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| ArfGAP With GTPase Domain, Ankyrin Repeat And PH Domain 41 2 | | AGAP-42 3 | | CTGLF11 2 3 | | Em:AC012044.11 | | MRIP21 2 3 | | ARF GTPase-Activating Protein2 | | Centaurin, Gamma-Like Family, Member 11 2 | | Arf-GAP With GTPase, ANK Repeat And PH Domain-Containing Protein 42 | | Centaurin-Gamma-Like Family Member 12 3 | | |
Export aliases for AGAP4 gene to outside databasesPrevious GC identifers: GC10M045643 GC10M045375 |
Summaries
for AGAP4 gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
UniProtKB/Swiss-Prot: AGAP4_HUMAN, Q96P64Function: Putative GTPase-activating protein (Potential)
|
Genomic Views
for AGAP4 gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000010.10 NC_018921.1 NT_033985.7
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the AGAP4 gene promoter:
AML1a Tal-1beta FOXL1 FOXJ2 (long isoform) HFH-1 FOXJ2 Pax-4a ITF-2
Other transcription factors
Search SABiosciences Chromatin IP Primers for AGAP4
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat AGAP4 |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 10q11.22 Ensembl cytogenetic band: 10q11.22 HGNC cytogenetic band: 10q11.21AGAP4 Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 10 GeneLoc Exon Structure GeneLoc location for GC10M046322: view genomic region
(about GC identifiers)
Start:
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46,321,042 bp from pter |
End:
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46,349,323 bp from pter |
Size:
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28,282 bases |
Orientation:
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minus strand |
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Proteins
for AGAP4 gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: AGAP4_HUMAN, Q96P64 (See
protein sequence)Recommended Name: Arf-GAP with GTPase, ANK repeat and PH domain-containing protein 4 Size: 663 amino acids; 73070 Da
Miscellaneous: Encoded by one of the numerous copies of centaurin gamma-like genes clustered in the q11 region ofchromosome 10Explore the universe of human proteins at neXtProt for AGAP4: NX_Q96P64
Post-translational modifications:
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_Q96P64
AGAP4 Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins: NP_597703.2
ENSEMBL proteins: ENSP00000392513 ENSP00000468160
Human Recombinant Protein Products:
AGAP4 Antibody Products:
Assay Products for AGAP4: |
Protein
Domains /
Families
for AGAP4 gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
AGAP4 for domains About GeneDecksing
5 InterPro domains/families:Graphical View of Domain Structure for InterPro Entry Q96P64ProtoNet protein and cluster: Q96P64 3 Blocks protein families: IPB001164 HIV Rev interacting protein signature IPB001849 Pleckstrin-like IPB002110 Ankyrin repeat signature
UniProtKB/Swiss-Prot: AGAP4_HUMAN, Q96P64Similarity: Belongs to the centaurin gamma-like familySimilarity: Contains 2 ANK repeatsSimilarity: Contains 1 Arf-GAP domainSimilarity: Contains 1 PH domain |
Function
for AGAP4 gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Function Summary:
UniProtKB/Swiss-Prot: AGAP4_HUMAN, Q96P64Function: Putative GTPase-activating protein (Potential)
Clone
Products: |  | Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore | |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for AGAP4
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for AGAP4
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
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Synthesis Service for AGAP4 | |  | Search Vector BioLabs for ready-to-use adenovirus/AAV for human, mouse, rat AGAP4 |
In Situ Assay
Products: |
 | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for AGAP4 |
Gene Ontology (GO): 3 molecular function terms (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0005543 | phospholipid binding |
IEA | -- | | GO:0008060 | ARF GTPase activator activity |
IEA | -- | | GO:0008270 | zinc ion binding |
IEA | -- |
AGAP4 for ontologies About GeneDecksing
1 GenomeRNAi human phenotype for AGAP4:
|
Pathways & Interactions
for AGAP4 gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Interactions:
Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for AGAP4
STRING Interaction
Network Preview (showing 1 interactants - click image to see more details)
1 Interacting protein for AGAP4 (ENSP000003925134) via UniProtKB, MINT, STRING, and/or I2DAbout this table
Gene Ontology (GO): 1 biological process term (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0032312 | regulation of ARF GTPase activity |
IEA | -- |
AGAP4 for ontologies About GeneDecksing
|
Drugs & Compounds
for AGAP4 gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
 Browse Tocris compounds for AGAP4
Search CenterWatch for drugs/clinical trials and news about AGAP4
|
Transcripts
for AGAP4 gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for AGAP4 gene: NM_133446.2 Unigene Cluster for AGAP4: ArfGAP with GTPase domain, ankyrin repeat and PH domain 4 Hs.656384 [show with all ESTs]Unigene Representative Sequence: AK0961075 Ensembl transcripts including schematic representations, and UCSC links where relevant: ENST00000448048(uc001jcx.4 uc021pps.1 uc010qfl.2 uc001jcy.4)
ENST00000430779 ENST00000492347 ENST00000495243 ENST00000490752
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for AGAP4
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for AGAP4
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript: all cDNA clones in your preferred vector: AGAP4 (NM_133446) | | | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for AGAP4 | | | Search Vector BioLabs for ready-to-use adenovirus/AAV for human, mouse, rat AGAP4 |
Additional cDNA sequence: AF411132.1 AK096107.1 BC048341.1 BC062366.1 BC171833.1 18 DOTS entries: DT.121289186 DT.95321258 DT.101979838 DT.445244 DT.92443635 DT.121288881 DT.437615 DT.100812744 DT.95274220 DT.101973107 DT.102828606 DT.102842747 DT.121222110 DT.121233727 DT.121280386 DT.121281807 DT.86856013 DT.97796057 24/112 AceView cDNA sequences (see all 112): AL542342 AA370813 AL045696 AF130105 AI114519 CA950419 BU567830 NM_133446 C00469 AI972947 AW440580 BX111919 BM811556 BV200259 BC048341 BM463163 BX372674 BV200258 BV201160 BX281178 CA436825 AL042956 BQ437372 BV202984
GeneLoc Exon Structure
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Expression
for AGAP4 gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| AGAP4 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: GCCCGAGATG
About this image
See AGAP4 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for AGAP4
SOURCE GeneReport for Unigene cluster: Hs.656384
SABiosciences Custom PCR Arrays for AGAP4
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for AGAP4
Browse OriGene validated miRNA SYBR primer pairs
| | | Search SABiosciences RT2 qPCR
Primer Assays in human, mouse, rat AGAP4 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat AGAP4 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat AGAP4 | In Situ
Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for AGAP4 |
Orthologs
for AGAP4 gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
This gene was present in the common ancestor of animals.
Orthologs for AGAP4 gene from 4/17 species (see all 17) About this table
ENSEMBL Gene Tree for AGAP4 (if available)
TreeFam Gene Tree for AGAP4 (if available) |
Paralogs
for AGAP4 gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| Paralogs for AGAP4 gene
- AGAP81 2 AGAP61 2 AGAP71 2 AGAP51 2 AGAP91 2 AGAP101 2 AGAP11 ASAP12
- ACAP22 ARAP32 GIT22 ACAP32 ARAP12 ASAP22 AGAP32 GIT12
- ARAP22 AGAP22 AGAP12 ACAP12 ASAP32
18/19 SIMAP similar genes for AGAP4 using alignment to 3 protein entries: AGAP4_HUMAN (see all proteins)
(see all similar genes):AGAP8 AGAP6 AGAP7 AGAP5 CTGLF11P AGAP10
AGAP11 AGAP9 FLJ00312 CENTG2 DKFZp761E2216 AGAP1
AGAP3 CCNYL2 CENTG3 CCNYL1 AGAP2 ARFGAP1
AGAP4 for paralogs About GeneDecksing
|
Genomic Variants
for AGAP4 gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr 10 pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
|---|
HapMap Linkage Disequilibrium report for AGAP4 (46321042 - 46349323 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 12 variations for AGAP4
12 CNVs: 9150 31726 8651 48537 8652 48536 3798 2863 48535 34456 48538 48539 | SABiosciences Cancer Mutation PCR Assays |
|
Disorders
/ Diseases
for AGAP4 gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
AGAP4 for disorders About GeneDecksing
1  disease for AGAP4: About MalaCardsmalaria
Export disorders for AGAP4 gene to outside databases
|
Publications
for AGAP4 gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for AGAP4 gene integrated from 9 sources:
(articles sorted by number of sources associating them with AGAP4) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1, 3 Strausberg R.L....Marra M.A. (2002)
- Charting the landscape of tandem BRCT domain-mediated protein interactions. (PubMed id 22990118)1 Woods N.T....Monteiro A.N. (2012)
- The DNA sequence and comparative analysis of human chromosome 10. (PubMed id 15164054)2 Deloukas P.... Rogers J. (2004)
- Hepatitis C virus core protein interacts with 14-3-3 protein and activates the kinase Raf-1. (PubMed id )2 Aoki H.... Hino O. (2000)
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External Searches for AGAP4 gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
|
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Genome Databases showing AGAP4 gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing AGAP4 gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing AGAP4 gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
| Name | Description |
| PharmGKB entry for AGAP4 | Pharmacogenomics, SNPs, Pathways |
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| | |
About This Section
| Patent Information for AGAP4 gene:
Search GeneIP for patents involving AGAP4
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for AGAP4 gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences),
In Situ Hybridization Assays from
Advanced Cell Diagnostics
About This Section
|
 | |
 | |
 |
| | |  | Browse OriGene Antibodies | | OriGene shRNA RFP for AGAP4 | | | OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for AGAP4 | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for AGAP4 | | | OriGene Protein Over-expression Lysate for AGAP4 | | Browse OriGene Fluorogenic Cell Assay Kits | | | OriGene siRNA for AGAP4 | | OriGene 3'-UTR Clone for AGAP4 | | | OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for AGAP4 | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for AGAP4 | | | Browse OriGene GFP tagged cDNA clones in CMV expression vector | | Browse OriGene MicroRNA Expression Plasmids | | | Browse OriGene basic RS shRNAs | | Browse OriGene validated miRNA SYBR primer pairs | | | Browse OriGene full length recombinant human proteins expressed in human HEK293 cells | | OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
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| | | QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat AGAP4 | | | Search QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing AGAP4 | | | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat AGAP4 | | | QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat AGAP4 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat AGAP4 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat AGAP4 |
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 | | | AGAP4 Proteins, Antibodies, CLIAs, and ELISAs |
| | | | | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for AGAP4 |
|  |  |  | | | | Search ThermoFisher Antibodies for AGAP4 |
| | | Search Vector BioLabs for ready-to-use adenovirus/AAV for human, mouse, rat AGAP4 |
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