Free for academic non-profit institutions. Other users need a Commercial license

Aliases for AGAP4 Gene

Aliases for AGAP4 Gene

  • ArfGAP With GTPase Domain, Ankyrin Repeat And PH Domain 4 2 3 5
  • ArfGAP With GTPase Domain, Ankyrin Repeat And PH Domain 8 2 3
  • Centaurin, Gamma-Like Family, Member 1 2 3
  • Centaurin, Gamma-Like Family, Member 5 2 3
  • CTGLF1 3 4
  • CTGLF5 3 4
  • AGAP-4 3 4
  • AGAP8 3 4
  • MRIP2 3 4
  • Arf-GAP With GTPase, ANK Repeat And PH Domain-Containing Protein 4 3
  • Arf-GAP With GTPase, ANK Repeat And PH Domain-Containing Protein 8 3
  • Centaurin-Gamma-Like Family Member 1 4
  • Centaurin-Gamma-Like Family Member 5 4
  • ARF GTPase-Activating Protein 3
  • AGAP-8 3

External Ids for AGAP4 Gene

Previous HGNC Symbols for AGAP4 Gene

  • CTGLF1
  • AGAP8
  • CTGLF5

Previous GeneCards Identifiers for AGAP4 Gene

  • GC10M045643
  • GC10M046322
  • GC10M045375

Summaries for AGAP4 Gene

GeneCards Summary for AGAP4 Gene

AGAP4 (ArfGAP With GTPase Domain, Ankyrin Repeat And PH Domain 4) is a Protein Coding gene. GO annotations related to this gene include GTPase activator activity. An important paralog of this gene is AGAP6.

UniProtKB/Swiss-Prot for AGAP4 Gene

  • Putative GTPase-activating protein.

No data available for Entrez Gene Summary , CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for AGAP4 Gene

Genomics for AGAP4 Gene

Regulatory Elements for AGAP4 Gene

Enhancers for AGAP4 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH10G046522 1.4 Ensembl ENCODE 108 -670.8 -670822 3.6 HDGF ARNT SIN3A YBX1 ZNF2 ZBTB7B ZNF766 ZNF207 ZNF143 FOS PARGP1 AGAP4 AGAP9 BMS1P1 WASHC2C FAM21FP LOC105378289 FAM35BP ANXA8L1 PTPN20
GH10G046028 1.4 ENCODE dbSUPER 40 -176.5 -176535 4.8 CREB3L1 ZFP64 DMAP1 YY1 SLC30A9 ZNF143 SP3 PPARGC1A MEF2D SSRP1 AGAP4 AGAP7P FAM21FP NCOA4 PIR52076 GC10M046012
GH10G046000 1.3 ENCODE dbSUPER 26 -148.3 -148334 3.5 HDGF PKNOX1 FOXA2 CREB3L1 ARNT ARID4B SIN3A YY1 ZNF766 KLF13 AGAP7P AGAP4 TIMM23 GC10P046001 PIR61640 PIR61931
GH10G044957 1.7 FANTOM5 ENCODE dbSUPER 15.3 +890.1 890061 12.3 HDGF FOXA2 PKNOX1 MLX CREB3L1 SIN3A ARID4B DMAP1 YBX1 ZNF2 TMEM72-AS1 ZNF22 AGAP4 C10orf25 ENSG00000223462 ENSG00000234504 TMEM72 RASSF4 CEP164P1 ALOX5
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around AGAP4 on UCSC Golden Path with GeneCards custom track

Genomic Location for AGAP4 Gene

45,825,592 bp from pter
45,853,877 bp from pter
28,286 bases
Minus strand

Genomic View for AGAP4 Gene

Genes around AGAP4 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
AGAP4 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for AGAP4 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for AGAP4 Gene

Proteins for AGAP4 Gene

  • Protein details for AGAP4 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Arf-GAP with GTPase, ANK repeat and PH domain-containing protein 4
    Protein Accession:

    Protein attributes for AGAP4 Gene

    663 amino acids
    Molecular mass:
    73070 Da
    Quaternary structure:
    No Data Available
    • Encoded by one of the numerous copies of centaurin gamma-like genes clustered in the q11 region of chromosome 10.

neXtProt entry for AGAP4 Gene

Post-translational modifications for AGAP4 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for AGAP4 Gene

Domains & Families for AGAP4 Gene

Suggested Antigen Peptide Sequences for AGAP4 Gene

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the centaurin gamma-like family.
  • Belongs to the centaurin gamma-like family.
genes like me logo Genes that share domains with AGAP4: view

Function for AGAP4 Gene

Molecular function for AGAP4 Gene

UniProtKB/Swiss-Prot Function:
Putative GTPase-activating protein.

Gene Ontology (GO) - Molecular Function for AGAP4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005096 GTPase activator activity IEA --
GO:0046872 metal ion binding IEA --
genes like me logo Genes that share ontologies with AGAP4: view
genes like me logo Genes that share phenotypes with AGAP4: view

Animal Model Products

miRNA for AGAP4 Gene

miRTarBase miRNAs that target AGAP4

Inhibitory RNA Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for AGAP4 Gene

Localization for AGAP4 Gene

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for AGAP4 gene
Compartment Confidence
cytosol 3
nucleus 2
extracellular 1
mitochondrion 1

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Gene Ontology (GO) - Cellular Components for AGAP4 Gene

Pathways & Interactions for AGAP4 Gene

SuperPathways for AGAP4 Gene

No Data Available

Gene Ontology (GO) - Biological Process for AGAP4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0043547 positive regulation of GTPase activity IEA --
genes like me logo Genes that share ontologies with AGAP4: view

No data available for Pathways by source and SIGNOR curated interactions for AGAP4 Gene

Drugs & Compounds for AGAP4 Gene

No Compound Related Data Available

Transcripts for AGAP4 Gene

Unigene Clusters for AGAP4 Gene

ArfGAP with GTPase domain, ankyrin repeat and PH domain 4:
Representative Sequences:

Inhibitory RNA Products

Alternative Splicing Database (ASD) splice patterns (SP) for AGAP4 Gene

No ASD Table

Relevant External Links for AGAP4 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for AGAP4 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for AGAP4 Gene

Protein differential expression in normal tissues from HIPED for AGAP4 Gene

This gene is overexpressed in Brain (69.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for AGAP4 Gene

Protein tissue co-expression partners for AGAP4 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of AGAP4 Gene:


SOURCE GeneReport for Unigene cluster for AGAP4 Gene:


Evidence on tissue expression from TISSUES for AGAP4 Gene

  • Liver(2.5)
  • Nervous system(2.4)
  • Intestine(2.1)
  • Kidney(2)
genes like me logo Genes that share expression patterns with AGAP4: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for AGAP4 Gene

Orthologs for AGAP4 Gene

This gene was present in the common ancestor of animals.

Orthologs for AGAP4 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia CTGLF2 34
  • 98.18 (n)
-- 35
  • 92 (a)
(Monodelphis domestica)
Mammalia -- 35
  • 73 (a)
(Ornithorhynchus anatinus)
Mammalia -- 35
  • 45 (a)
(Gallus gallus)
Aves -- 35
  • 57 (a)
(Anolis carolinensis)
Reptilia -- 35
  • 63 (a)
-- 35
  • 10 (a)
(Danio rerio)
Actinopterygii agap1 35
  • 46 (a)
fruit fly
(Drosophila melanogaster)
Insecta cenG1A 35
  • 26 (a)
(Caenorhabditis elegans)
Secernentea cnt-2 35
  • 20 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 35
  • 34 (a)
Species where no ortholog for AGAP4 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • cow (Bos Taurus)
  • dog (Canis familiaris)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • mouse (Mus musculus)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)

Evolution for AGAP4 Gene

Gene Tree for AGAP4 (if available)
Gene Tree for AGAP4 (if available)

Paralogs for AGAP4 Gene Pseudogenes for AGAP4 Gene

genes like me logo Genes that share paralogs with AGAP4: view

Variants for AGAP4 Gene

Sequence variations from dbSNP and Humsavar for AGAP4 Gene

SNP ID Clin Chr 10 pos Sequence Context AA Info Type
rs1057791 -- 45,855,951(-) CTGTA(C/T)ACTCT intron-variant, utr-variant-5-prime
rs10666313 -- 45,857,168(+) CACAC(-/AC/CC/CG)GCACG intron-variant, utr-variant-5-prime
rs111351178 -- 45,830,503(+) TTTGT(G/T)TAGGC intron-variant
rs111572815 -- 45,832,504(+) GCTTT(C/G)GGCAT intron-variant
rs11239607 -- 45,825,275(+) CATGG(G/T)CCGGG downstream-variant-500B

Structural Variations from Database of Genomic Variants (DGV) for AGAP4 Gene

Variant ID Type Subtype PubMed ID
nsv1118165 CNV deletion 24896259
nsv8630 CNV loss 18304495
nsv947917 CNV duplication 23825009
nsv971743 CNV duplication 23825009
nsv974928 CNV duplication 23825009
nsv974930 CNV duplication 23825009
nsv975686 CNV duplication 23825009
nsv982752 CNV duplication 23825009

Variation tolerance for AGAP4 Gene

Gene Damage Index Score: 1.98; 36.61% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for AGAP4 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for AGAP4 Gene

Disorders for AGAP4 Gene

Relevant External Links for AGAP4

Atlas of Genetics and Cytogenetics in Oncology and Haematology:

No disorders were found for AGAP4 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for AGAP4 Gene

Publications for AGAP4 Gene

  1. The DNA sequence and comparative analysis of human chromosome 10. (PMID: 15164054) Deloukas P. … Rogers J. (Nature 2004) 3 4 64
  2. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg R.L. … Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002) 2 3 64
  3. The functional landscape of Hsp27 reveals new cellular processes such as DNA repair and alternative splicing and proposes novel anticancer targets. (PMID: 25277244) Katsogiannou M. … Rocchi P. (Mol. Cell Proteomics 2014) 3 64
  4. Charting the landscape of tandem BRCT domain-mediated protein interactions. (PMID: 22990118) Woods N.T. … Monteiro A.N. (Sci Signal 2012) 3 64
  5. Exome sequencing identifies frequent mutation of the SWI/SNF complex gene PBRM1 in renal carcinoma. (PMID: 21248752) Varela I. … Futreal P.A. (Nature 2011) 3 64

Products for AGAP4 Gene

Sources for AGAP4 Gene

Loading form....