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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

AGAP3 Gene

protein-coding   GIFtS: 51
GCID: GC07P150782

ArfGAP With GTPase Domain, Ankyrin Repeat And PH Domain...

(Previous names: centaurin, gamma 3)
(Previous symbol: CENTG3)
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
ArfGAP With GTPase Domain, Ankyrin Repeat And PH Domain 31 2     MR1-Interacting Protein2 3
CENTG31 2 3     Arf-GAP With GTPase, ANK Repeat And PH Domain-Containing Protein 32
Centaurin, Gamma 31 2     centaurin-gamma-32
AGAP-32 3     cnt-g32
CRAG2 3     CRMP (Collapsin Response Mediator Protein) Associated2
MRIP-12 3     Centaurin-gamma-33
CRAM-Associated GTPase2 3     Cnt-g33

External Ids:    HGNC: 169231   Entrez Gene: 1169882   Ensembl: ENSG000001336127   UniProtKB: Q96P473   

Export aliases for AGAP3 gene to outside databases

Previous GC identifers: GC07P150415 GC07P144596


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

GeneCards Summary for AGAP3 Gene: 
AGAP3 (ArfGAP with GTPase domain, ankyrin repeat and PH domain 3) is a protein-coding gene. Diseases associated with AGAP3 include cryptococcosis, and machado-joseph disease. GO annotations related to this gene include GTP binding and GTPase activity. An important paralog of this gene is AGAP5.

UniProtKB/Swiss-Prot: AGAP3_HUMAN, Q96P47
Function: GTPase-activating protein for the ADP ribosylation factor family (Potential). GTPase which may be
involved in the degradation of expanded polyglutamine proteins through the ubiquitin-proteasome pathway

Gene Wiki entry for AGAP3 (CENTG3) Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000007.13  NT_007914.15  NC_018918.2  NT_079596.2  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the AGAP3 gene promoter:
         GR   p53   GR-beta   GR-alpha   C/EBPalpha   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmids (see all 6): AGAP3 promoter sequence
   Search SABiosciences Chromatin IP Primers for AGAP3

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat AGAP3


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 7q36.1   Ensembl cytogenetic band:  7q36.1   HGNC cytogenetic band: 7q36.1

AGAP3 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
AGAP3 gene location

GeneLoc information about chromosome 7         GeneLoc Exon Structure

GeneLoc location for GC07P150782:  view genomic region     (about GC identifiers)

Start:
150,782,918 bp from pter      End:
150,841,523 bp from pter
Size:
58,606 bases      Orientation:
plus strand

1 alternative location:
Chr7+,CRA_TCAG 150,113,360-150,171,043     

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: AGAP3_HUMAN, Q96P47 (See protein sequence)
Recommended Name: Arf-GAP with GTPase, ANK repeat and PH domain-containing protein 3  
Size: 875 amino acids; 95044 Da
Subunit: Interacts with PML. Interacts with expanded polyglutamine proteins
Subcellular location: Cytoplasm. Note=In cells upon oxidative stress or in brains of Machado-Joseph disease
patients, translocates to PML nuclear bodies
1 PDB 3D structure from and Proteopedia for AGAP3:
3IHW (3D)    
Secondary accessions: Q59EN0 Q96RK3
Alternative splicing: 4 isoforms:  Q96P47-1   Q96P47-2   Q96P47-3   Q96P47-4   

Explore the universe of human proteins at neXtProt for AGAP3: NX_Q96P47

Explore proteomics data for AGAP3 at MOPED 

Post-translational modifications:

  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_Q96P47

  • AGAP3 Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    AGAP3 Protein Expression
    REFSEQ proteins (3 alternative transcripts): 
    NP_001036000.1  NP_001268229.1  NP_114152.3  

    ENSEMBL proteins: 
     ENSP00000418016   ENSP00000418921   ENSP00000418125   ENSP00000380413   ENSP00000417151  
     ENSP00000335589   ENSP00000419801   ENSP00000418159   ENSP00000417910  

    Human Recombinant Protein Products for AGAP3: 
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    Browse Sino Biological Cell Lysates 
    Browse ProSpec Recombinant Proteins
    Browse Proteins at Cloud-Clone Corp. 

    Gene Ontology (GO): 5 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005622intracellular ----
    GO:0005634nucleus IEA--
    GO:0005737cytoplasm IEA--
    GO:0016020membrane IEA--
    GO:0071944cell periphery IEA--

    AGAP3 for ontologies           About GeneDecksing



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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    HGNC Gene Families: 
    PLEKH: Pleckstrin homology (PH) domain containing
    ANKRD: Ankyrin repeat domain containing
    ArfGAP: ADP-ribosylation factor GTPase activating proteins

    5/8 InterPro protein domains (see all 8):
     IPR027417 P-loop_NTPase
     IPR013684 MIRO-like
     IPR001849 Pleckstrin_homology
     IPR001164 ArfGAP
     IPR020849 Small_GTPase_Ras

    Graphical View of Domain Structure for InterPro Entry Q96P47

    ProtoNet protein and cluster: Q96P47

    4 Blocks protein domains:
    IPB001164 HIV Rev interacting protein signature
    IPB001849 Pleckstrin-like
    IPB002110 Ankyrin repeat signature
    IPB013684 Miro-like


    UniProtKB/Swiss-Prot: AGAP3_HUMAN, Q96P47
    Similarity: Belongs to the centaurin gamma-like family
    Similarity: Contains 3 ANK repeats
    Similarity: Contains 1 Arf-GAP domain
    Similarity: Contains 1 PH domain


    AGAP3 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: AGAP3_HUMAN, Q96P47
    Function: GTPase-activating protein for the ADP ribosylation factor family (Potential). GTPase which may be
    involved in the degradation of expanded polyglutamine proteins through the ubiquitin-proteasome pathway
    Enzyme regulation: GTPase activity is stimulated by oxidative stress

         Gene Ontology (GO): 5/7 molecular function terms (GO ID links to tree view) (see all 7):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003924GTPase activity IEA--
    GO:0005515protein binding ----
    GO:0005525GTP binding IEA--
    GO:0005543phospholipid binding IEA--
    GO:0008060ARF GTPase activator activity IEA--
         
    AGAP3 for ontologies           About GeneDecksing


    Phenotypes:
         2 GenomeRNAi human phenotypes for AGAP3:
     Decreased number of cells in m  Decreased viability with pacli 

    Animal Models:
       inGenious Targeting Laboratory - Custom generated mouse model solutions for AGAP3 
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    miRNA
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    8/43 QIAGEN miScript miRNA Assays for microRNAs that regulate AGAP3 (see all 43):
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    SwitchGear 3'UTR luciferase reporter plasmidAGAP3 3' UTR sequence
    Inhib. RNA
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    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section

    SuperPaths for AGAP3 About                                                                                                See pathways by source

    SuperPathContained pathways About
    1Endocytosis
    Endocytosis

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways



    1         Kegg Pathway  (Kegg details for AGAP3):
        Endocytosis


    AGAP3 for pathways           About GeneDecksing

    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for AGAP3

    STRING Interaction Network Preview (showing 2 interactants - click image to see more details)

    5/22 Interacting proteins for AGAP3 (Q96P473 ENSP000003804134) via UniProtKB, MINT, STRING, and/or I2D (see all 22)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    GLI2P100703I2D: score=4 
    AKT3Q9Y2433I2D: score=3 
    ARHGAP1Q079603I2D: score=3 
    C12orf4Q9NQ893I2D: score=3 
    CCNA1P783963I2D: score=3 
    About this table

    Gene Ontology (GO): 5/8 biological process terms (GO ID links to tree view) (see all 8):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000060protein import into nucleus, translocation IEA--
    GO:0006184GTP catabolic process ----
    GO:0007165signal transduction ----
    GO:0007264small GTPase mediated signal transduction IEA--
    GO:0015031protein transport ----

    AGAP3 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for AGAP3

    Search CenterWatch for drugs/clinical trials and news about AGAP3

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for AGAP3 gene (3 alternative transcripts): 
    NM_001042535.2  NM_001281300.1  NM_031946.5  

    Unigene Cluster for AGAP3:

    ArfGAP with GTPase domain, ankyrin repeat and PH domain 3
    Hs.647075  [show with all ESTs]
    Unigene Representative Sequence: AL442089
    18/25 Ensembl transcripts including schematic representations, and UCSC links where relevant (see all 25):
    ENST00000490097 ENST00000463381(uc003wje.1) ENST00000473312(uc003wjf.1)
    ENST00000479901(uc010lpy.1) ENST00000397238(uc003wjg.1 uc003wjj.1)
    ENST00000469901 ENST00000476375 ENST00000492234 ENST00000335367(uc003wjh.1)
    ENST00000473140 ENST00000490839 ENST00000467724 ENST00000468796 ENST00000480106
    ENST00000498559 ENST00000486946 ENST00000475145 ENST00000463179
    miRNA
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    8/43 QIAGEN miScript miRNA Assays for microRNAs that regulate AGAP3 (see all 43):
    hsa-miR-15a hsa-miR-485-3p hsa-miR-765 hsa-miR-486-3p hsa-miR-29b-1* hsa-miR-424 hsa-miR-629 hsa-miR-3150b-3p
    SwitchGear 3'UTR luciferase reporter plasmidAGAP3 3' UTR sequence
    Inhib. RNA
    Products:
         
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    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat AGAP3
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      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat AGAP3

    Additional mRNA sequence: 

    AB209781.1 AF413079.1 AK027415.1 AK055393.1 AK091771.1 AK096352.1 AL442089.1 BC020426.1 
    BC037543.1 BC044644.1 BC048300.1 

    24/31 DOTS entries (see all 31):

    DT.100811659  DT.75100587  DT.100058684  DT.121111111  DT.97847223  DT.85102022  DT.87046929  DT.100811656 
    DT.100811662  DT.97791697  DT.121111038  DT.121111078  DT.40132677  DT.92422879  DT.95130700  DT.100766181 
    DT.100811661  DT.92422876  DT.121111082  DT.121111103  DT.121111105  DT.100698862  DT.121111060  DT.121111066 

    24/269 AceView cDNA sequences (see all 269):

    BQ188530 BU624887 NM_031946 BM723317 BQ428566 BF434291 BM931941 BC069236 
    BF940554 CD674188 AI913087 AI560349 CD676064 CA866107 AI903172 BC048300 
    BF528096 AI001048 BM669703 AI494590 BI490023 AA779405 BC037543 AI417314 

    GeneLoc Exon Structure

    5/16 Alternative Splicing Database (ASD) splice patterns (SP) for AGAP3 (see all 16)    About this scheme

    ExUns: 1a · 1b · 1c ^ 2a · 2b · 2c ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10a · 10b · 10c · 10d ^ 11a · 11b ^ 12a · 12b ^ 13a · 13b · 13c ^ 14a · 14b ^
    SP1:                                      -     -     -     -                                         -     -                                         -     -   
    SP2:              -     -     -     -     -     -     -     -                                         -     -                                         -     -   
    SP3:                                                        -                                         -     -                                         -     -   
    SP4:                                      -     -     -     -                                         -     -                                         -     -   
    SP5:                                                                                                                                                            

    ExUns: 15a · 15b ^ 16a · 16b ^ 17a · 17b · 17c ^ 18 ^ 19a · 19b ^ 20 ^ 21 ^ 22 ^ 23a · 23b ^ 24 ^ 25 ^ 26 ^ 27a · 27b
    SP1:  -     -     -                             -                 -                 -                                       
    SP2:  -     -     -                             -                 -     -     -     -                                       
    SP3:                                                                                                                        
    SP4:                                                                                                                        
    SP5:                                                              -     -           -                                       


    ECgene alternative splicing isoforms for AGAP3

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    AGAP3 expression in normal human tissues (normalized intensities)      AGAP3 embryonic expression: see
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: TAAACTTTGT
    AGAP3 Expression
    About this image


    AGAP3 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database 
     5/2 selected tissues (see all 2) fully expand
     
     Pancreas (Endocrine System)
             Posterior foregut-like cells ( A scalable, suspension protocol for derivation of...
     
     Eye (Sensory Organs)
             retinal amacrine cell p0   

    See AGAP3 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for AGAP3

    SOURCE GeneReport for Unigene cluster: Hs.647075

    UniProtKB/Swiss-Prot: AGAP3_HUMAN, Q96P47
    Tissue specificity: Widely expressed

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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for AGAP3

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of animals.

    Orthologs for AGAP3 gene from 6/12 species (see all 12)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Agap31 , 5 ArfGAP with GTPase domain, ankyrin repeat and PH domain more1, 5 89.43(n)1
    96.37(a)1
      5 (11.81 cM)5
    2139901  NM_139153.21  NP_631892.21 
     244521775 
    chicken
    (Gallus gallus)
    Aves AGAP31 ArfGAP with GTPase domain, ankyrin repeat and PH domain more 76.04(n)
    80.37(a)
      768507  XM_003640631.1  XP_003640679.1 
    African clawed frog
    (Xenopus laevis)
    Amphibia BG813775.12   -- 81.87(n)    BG813775.1 
    zebrafish
    (Danio rerio)
    Actinopterygii AGAP3 (1 of 2)6
    AGAP3 (2 of 2)6
    ArfGAP with GTPase domain, ankyrin repeat and PH d...
    ArfGAP with GTPase domain, ankyrin repeat and PH d...
    75(a)
    40(a)
    1 ↔ many
    1 ↔ many
    24(35366423-35412751)
    24(35552451-35679893)
    fruit fly
    (Drosophila melanogaster)
    Insecta cenG1A6
    centaurin gamma 1A
    41(a)
    1 → many
    2L(13835567-13898715)
    worm
    (Caenorhabditis elegans)
    Secernentea cnt-26
    Protein CNT-2, isoform b
    27(a)
    1 → many
    III(10655770-10677522)


    ENSEMBL Gene Tree for AGAP3 (if available)
    TreeFam Gene Tree for AGAP3 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for AGAP3 gene
    AGAP52  AGAP62  ASAP12  ARAP32  ACAP22  ACAP32  ASAP22  ARAP12  
    ARAP22  AGAP22  AGAP42  AGAP12  AGAP82  ACAP12  AGAP72  AGAP102  
    AGAP92  ASAP32  
    18/21 SIMAP similar genes for AGAP3 using alignment to 11 protein entries:     AGAP3_HUMAN (see all proteins) (see all similar genes):
    DKFZp761E2216    CENTG3    CENTG2    AGAP1    AGAP11    AGAP4
    AGAP5    AGAP6    AGAP8    AGAP7    CTGLF11P    AGAP9
    AGAP10    AGAP2    ADAP1    SMAP1    FLJ00312    ARFGAP3

    AGAP3 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/1306 SNPs in AGAP3 are shown (see all 1306)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 7 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1406059091,2
    --150782672(+) GGTGGC/GGGGGA 2 -- us2k10--------
    rs563532091,2
    C,F--150782693(+) AGAACT/CGCAGC 2 -- us2k12Minor allele frequency- C:0.20WA 120
    rs1153361541,2
    F--150782822(+) GGGCTT/CTGGTT 2 -- us2k11Minor allele frequency- C:0.03WA 118
    rs1140586021,2
    F--150782884(+) TCCCTC/TTTCTT 2 -- us2k11Minor allele frequency- T:0.02WA 118
    rs1504722131,2
    --150782979(+) CAGCCC/GGCAGT 2 -- us2k10--------
    rs726173521,2
    C--150783103(+) TAAGCG/AAGGAG 2 -- us2k13Minor allele frequency- A:0.23WA EA 240
    rs1926826421,2
    --150783157(+) GCAGCA/GCCCTC 2 -- us2k10--------
    rs2001512431,2
    --150784001(+) GCCCCC/TCCAGC 4 P L mis10--------
    rs1383228981,2
    C--150784028(+) CTCCGC/TGGCCA 4 A V mis10--------
    rs2017922171,2
    --150784201(+) GTGGCC/TTCTCC 2 -- int10--------

    HapMap Linkage Disequilibrium report for AGAP3 (150782918 - 150841523 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 10/13 variations for AGAP3 (see all 13):    About this table     
    Variant IDTypeSubtypePubMed ID
    nsv6004CNV Insertion18451855
    esv22632CNV Loss19812545
    dgv7547n71CNV Loss21882294
    dgv7546n71CNV Loss21882294
    nsv527369CNV Loss19592680
    dgv7548n71CNV Loss21882294
    nsv889477CNV Loss21882294
    nsv465215CNV Loss19166990
    nsv889465CNV Loss21882294
    dgv436n21CNV Loss19592680

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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    4 diseases for AGAP3:    About MalaCards
    cryptococcosis    machado-joseph disease    meningitis    leukemia


    AGAP3 for disorders           About GeneDecksing

    Genetic Association Database (GAD): AGAP3

    Export disorders for AGAP3 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for AGAP3 gene, integrated from 9 sources (see all 15):
    (articles sorted by number of sources associating them with AGAP3)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. A novel GTPase, CRAG, mediates promyelocytic leukemia protein- associated nuclear body formation and degradation of expanded polyglutamine protein. (PubMed id 16461359)1, 2 Qin Q.... Yanagi S. (2006)
    2. A probability-based approach for high-throughput protein phosphorylation analysis and site localization. (PubMed id 16964243)1, 2 Beausoleil S.A.... Gygi S.P. (2006)
    3. AGAP1, a novel binding partner of nitric oxide-sensitive guanylyl cyclase. (PubMed id 15381706)1, 2 Meurer S.... Gross S. (2004)
    4. GGAPs, a new family of bifunctional GTP-binding and GTPase-activating proteins. (PubMed id 12640130)1, 2 Xia C.... Liu M. (2003)
    5. Systematic and quantitative assessment of the ubiquiti n-modified proteome. (PubMed id 21906983)1 Kim W....Gygi S.P. (2011)
    6. Mass spectrometric analysis of lysine ubiquitylation r eveals promiscuity at site level. (PubMed id 21139048)1 Danielsen J.M....Nielsen M.L. (2011)
    7. A proteome-wide, quantitative survey of in vivo ubiqui tylation sites reveals widespread regulatory roles. (PubMed id 21890473)1 Wagner S.A....Choudhary C. (2011)
    8. Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach. (PubMed id 19413330)2 Gauci S....Mohammed S. (2009)
    9. A quantitative atlas of mitotic phosphorylation. (PubMed id 18669648)2 Dephoure N.... Gygi S.P. (2008)
    10. Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. (PubMed id 16344560)1 Kimura K.... Sugano S. (2006)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 116988 HGNC: 16923 AceView: CENTG3 Ensembl:ENSG00000133612 euGenes: HUgn116988
    ECgene: AGAP3 Kegg: 116988 H-InvDB: AGAP3

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for AGAP3 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for AGAP3 gene:
    Search GeneIP for patents involving AGAP3

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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    GeneCards Homepage - Last full update: 23 Oct 2013 - Incrementals: 4 Nov 2013 , 7 Nov 2013 , 23 Jan 2014

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