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Aliases for AGAP3 Gene

Aliases for AGAP3 Gene

  • ArfGAP With GTPase Domain, Ankyrin Repeat And PH Domain 3 2 3
  • MR1-Interacting Protein 3 4
  • CRAM-Associated GTPase 3 4
  • Centaurin, Gamma 3 2 3
  • Centaurin-Gamma-3 3 4
  • Cnt-G3 3 4
  • CENTG3 3 4
  • AGAP-3 3 4
  • MRIP-1 3 4
  • CRAG 3 4
  • CRMP (Collapsin Response Mediator Protein) Associated 3

External Ids for AGAP3 Gene

Previous HGNC Symbols for AGAP3 Gene

  • CENTG3

Previous GeneCards Identifiers for AGAP3 Gene

  • GC07P150415
  • GC07P150782
  • GC07P144596

Summaries for AGAP3 Gene

GeneCards Summary for AGAP3 Gene

AGAP3 (ArfGAP With GTPase Domain, Ankyrin Repeat And PH Domain 3) is a Protein Coding gene. Among its related pathways are Endocytosis. GO annotations related to this gene include GTP binding and GTPase activator activity. An important paralog of this gene is ASAP3.

UniProtKB/Swiss-Prot for AGAP3 Gene

  • GTPase-activating protein for the ADP ribosylation factor family (Potential). GTPase which may be involved in the degradation of expanded polyglutamine proteins through the ubiquitin-proteasome pathway.

Gene Wiki entry for AGAP3 Gene

No data available for Entrez Gene Summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for AGAP3 Gene

Genomics for AGAP3 Gene

Regulatory Elements for AGAP3 Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for AGAP3 Gene

Chromosome:
7
Start:
151,085,831 bp from pter
End:
151,144,436 bp from pter
Size:
58,606 bases
Orientation:
Plus strand

Genomic View for AGAP3 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for AGAP3 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for AGAP3 Gene

Proteins for AGAP3 Gene

  • Protein details for AGAP3 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q96P47-AGAP3_HUMAN
    Recommended name:
    Arf-GAP with GTPase, ANK repeat and PH domain-containing protein 3
    Protein Accession:
    Q96P47
    Secondary Accessions:
    • B3KNZ8
    • E9PAL8
    • Q59EN0
    • Q96RK3

    Protein attributes for AGAP3 Gene

    Size:
    875 amino acids
    Molecular mass:
    95044 Da
    Quaternary structure:
    • Interacts with PML. Interacts with expanded polyglutamine proteins.

    Three dimensional structures from OCA and Proteopedia for AGAP3 Gene

    Alternative splice isoforms for AGAP3 Gene

neXtProt entry for AGAP3 Gene

Proteomics data for AGAP3 Gene at MOPED

Post-translational modifications for AGAP3 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for AGAP3 Gene

Domains & Families for AGAP3 Gene

Graphical View of Domain Structure for InterPro Entry

Q96P47

UniProtKB/Swiss-Prot:

AGAP3_HUMAN :
  • Contains 1 Arf-GAP domain.
  • Belongs to the centaurin gamma-like family.
  • Contains 3 ANK repeats.
Domain:
  • Contains 1 Arf-GAP domain.
  • Contains 1 PH domain.
Family:
  • Belongs to the centaurin gamma-like family.
Similarity:
  • Contains 3 ANK repeats.
genes like me logo Genes that share domains with AGAP3: view

Function for AGAP3 Gene

Molecular function for AGAP3 Gene

UniProtKB/Swiss-Prot EnzymeRegulation:
GTPase activity is stimulated by oxidative stress.
UniProtKB/Swiss-Prot Function:
GTPase-activating protein for the ADP ribosylation factor family (Potential). GTPase which may be involved in the degradation of expanded polyglutamine proteins through the ubiquitin-proteasome pathway.

Gene Ontology (GO) - Molecular Function for AGAP3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005096 GTPase activator activity IEA --
GO:0005515 protein binding --
GO:0005525 GTP binding IEA --
GO:0046872 metal ion binding IEA --
genes like me logo Genes that share ontologies with AGAP3: view
genes like me logo Genes that share phenotypes with AGAP3: view

miRNA for AGAP3 Gene

miRTarBase miRNAs that target AGAP3

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for AGAP3

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Animal Models , Transcription Factor Targets and HOMER Transcription for AGAP3 Gene

Localization for AGAP3 Gene

Subcellular locations from UniProtKB/Swiss-Prot for AGAP3 Gene

Cytoplasm. Note=In cells upon oxidative stress or in brains of Machado-Joseph disease patients, translocates to PML nuclear bodies.

Gene Ontology (GO) - Cellular Components for AGAP3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005622 intracellular --
GO:0005737 cytoplasm IEA --
GO:0016020 membrane IEA --
genes like me logo Genes that share ontologies with AGAP3: view

No data available for Subcellular locations from COMPARTMENTS for AGAP3 Gene

Pathways & Interactions for AGAP3 Gene

SuperPathways for AGAP3 Gene

Superpath Contained pathways
1 Endocytosis
genes like me logo Genes that share pathways with AGAP3: view

Pathways by source for AGAP3 Gene

1 KEGG pathway for AGAP3 Gene

Interacting Proteins for AGAP3 Gene

Gene Ontology (GO) - Biological Process for AGAP3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007165 signal transduction --
GO:0007264 small GTPase mediated signal transduction IEA --
GO:0015031 protein transport --
GO:0043547 positive regulation of GTPase activity IEA --
genes like me logo Genes that share ontologies with AGAP3: view

No data available for SIGNOR curated interactions for AGAP3 Gene

Drugs & Compounds for AGAP3 Gene

No Compound Related Data Available

Transcripts for AGAP3 Gene

Unigene Clusters for AGAP3 Gene

ArfGAP with GTPase domain, ankyrin repeat and PH domain 3:
Representative Sequences:

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for AGAP3

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for AGAP3 Gene

ExUns: 1a · 1b · 1c ^ 2a · 2b · 2c ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10a · 10b · 10c · 10d ^ 11a · 11b ^ 12a · 12b ^ 13a · 13b · 13c ^ 14a · 14b ^
SP1: - - - - - - - -
SP2: - - - - - - - - - - - -
SP3: - - - - -
SP4: - - - - - - - -
SP5:
SP6: - - - - - - -
SP7: - - - -
SP8:
SP9: -
SP10: - -
SP11:
SP12:
SP13:
SP14:
SP15:
SP16:

ExUns: 15a · 15b ^ 16a · 16b ^ 17a · 17b · 17c ^ 18 ^ 19a · 19b ^ 20 ^ 21 ^ 22 ^ 23a · 23b ^ 24 ^ 25 ^ 26 ^ 27a · 27b
SP1: - - - - - -
SP2: - - - - - - - -
SP3:
SP4:
SP5: - - -
SP6:
SP7:
SP8:
SP9:
SP10:
SP11:
SP12: -
SP13: -
SP14:
SP15:
SP16:

Relevant External Links for AGAP3 Gene

GeneLoc Exon Structure for
AGAP3
ECgene alternative splicing isoforms for
AGAP3

Expression for AGAP3 Gene

mRNA expression in normal human tissues for AGAP3 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for AGAP3 Gene

This gene is overexpressed in Adrenal (21.6), Fetal Brain (17.5), and Frontal cortex (10.1).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for AGAP3 Gene



SOURCE GeneReport for Unigene cluster for AGAP3 Gene Hs.647075

mRNA Expression by UniProt/SwissProt for AGAP3 Gene

Q96P47-AGAP3_HUMAN
Tissue specificity: Widely expressed.
genes like me logo Genes that share expression patterns with AGAP3: view

Protein tissue co-expression partners for AGAP3 Gene

- Elite partner

Primer Products

In Situ Assay Products

No data available for mRNA differential expression in normal tissues for AGAP3 Gene

Orthologs for AGAP3 Gene

This gene was present in the common ancestor of animals.

Orthologs for AGAP3 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia AGAP3 35
  • 89.4 (n)
  • 93.19 (a)
AGAP3 36
  • 94 (a)
OneToOne
dog
(Canis familiaris)
Mammalia AGAP3 35
  • 92.22 (n)
  • 96.69 (a)
AGAP3 36
  • 95 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Agap3 35
  • 89.81 (n)
  • 97.21 (a)
Agap3 16
Agap3 36
  • 96 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia AGAP3 35
  • 99.73 (n)
  • 99.88 (a)
AGAP3 36
  • 99 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Agap3 35
  • 88.24 (n)
  • 93.62 (a)
oppossum
(Monodelphis domestica)
Mammalia AGAP3 36
  • 91 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia AGAP3 36
  • 59 (a)
OneToOne
chicken
(Gallus gallus)
Aves AGAP3 35
  • 78.38 (n)
  • 85.15 (a)
AGAP3 36
  • 81 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia -- 36
  • 60 (a)
ManyToMany
zebrafish
(Danio rerio)
Actinopterygii AGAP3 (1 of 2) 36
  • 75 (a)
OneToMany
AGAP3 (2 of 2) 36
  • 42 (a)
OneToMany
fruit fly
(Drosophila melanogaster)
Insecta cenG1A 36
  • 42 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea cnt-2 36
  • 31 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 50 (a)
OneToMany
Species with no ortholog for AGAP3:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)

Evolution for AGAP3 Gene

ENSEMBL:
Gene Tree for AGAP3 (if available)
TreeFam:
Gene Tree for AGAP3 (if available)

Paralogs for AGAP3 Gene

genes like me logo Genes that share paralogs with AGAP3: view

Variants for AGAP3 Gene

Sequence variations from dbSNP and Humsavar for AGAP3 Gene

SNP ID Clin Chr 07 pos Sequence Context AA Info Type MAF
rs77076228 -- 151,104,143(+) TTAGC(A/G)TCCAT intron-variant
rs77222700 -- 151,139,921(+) CCTGC(A/G)CCCCT intron-variant
rs77332378 -- 151,141,136(+) AGTCA(C/T)ACTGC intron-variant
rs77484182 -- 151,122,369(+) TGTGT(C/T)CCCTC intron-variant
rs77511477 -- 151,100,332(+) GGCTT(A/G)GTGTG intron-variant

Structural Variations from Database of Genomic Variants (DGV) for AGAP3 Gene

Variant ID Type Subtype PubMed ID
nsv889465 CNV Loss 21882294
nsv889476 CNV Loss 21882294
nsv889477 CNV Loss 21882294
dgv7545n71 CNV Loss 21882294
nsv831188 CNV Loss 17160897
dgv7546n71 CNV Loss 21882294
nsv465215 CNV Loss 19166990
nsv6004 CNV Insertion 18451855
dgv7547n71 CNV Loss 21882294
dgv7548n71 CNV Loss 21882294
esv22632 CNV Loss 19812545
nsv527369 CNV Loss 19592680
dgv436n21 CNV Loss 19592680

Variation tolerance for AGAP3 Gene

Residual Variation Intolerance Score: 6.29% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.10; 38.38% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for AGAP3 Gene

HapMap Linkage Disequilibrium report
AGAP3

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for AGAP3 Gene

Disorders for AGAP3 Gene

Relevant External Links for AGAP3

Genetic Association Database (GAD)
AGAP3
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
AGAP3
genes like me logo Genes that share disorders with AGAP3: view

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for AGAP3 Gene

Publications for AGAP3 Gene

  1. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin E.L. … Gygi S.P. (Cell 2015) 67
  2. Temporal proteomics of NGF-TrkA signaling identifies an inhibitory role for the E3 ligase Cbl-b in neuroblastoma cell differentiation. (PMID: 25921289) Emdal K.B. … Olsen J.V. (Sci Signal 2015) 67
  3. The functional landscape of Hsp27 reveals new cellular processes such as DNA repair and alternative splicing and proposes novel anticancer targets. (PMID: 25277244) Katsogiannou M. … Rocchi P. (Mol. Cell Proteomics 2014) 67
  4. An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome. (PMID: 24275569) Bian Y. … Zou H. (J. Proteomics 2014) 67
  5. AGAP3 and Arf6 regulate trafficking of AMPA receptors and synaptic plasticity. (PMID: 23904596) Oku Y. … Huganir R.L. (J. Neurosci. 2013) 67

Products for AGAP3 Gene

Sources for AGAP3 Gene

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