AGAP2 Gene
protein-coding GIFtS: 60
GCID: GC12M058118
|
|
ArfGAP with GTPase domain, ankyrin repeat and PH domain...(Previous names: centaurin, gamma 1 )
(Previous symbol: CENTG1)
| |
Aliases
for AGAP2 gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| ArfGAP With GTPase Domain, Ankyrin Repeat And PH Domain 21 2 | | GTP-Binding And GTPase Activating Protein 22 | | CENTG11 2 3 | | Phosphatidylinositol-3-Kinase Enhancer2 | | PIKE2 3 5 | | Phosphoinositide 3-Kinase Enhancer2 | | Centaurin, Gamma 11 2 | | AGAP-23 | | Phosphatidylinositol 3-Kinase Enhancer2 3 | | Centaurin-Gamma-11 | | GGAP22 3 | | Cnt-G11 | | Arf GAP With GTP-Binding Protein-Like, ANK Repeat And PH Domains 22 | | KIAA01673 | | Arf-GAP With GTPase, ANK Repeat And PH Domain-Containing Protein 22 | | GTP-Binding And GTPase-Activating Protein 23 | | Cnt-G11 | | |
Export aliases for AGAP2 gene to outside databasesPrevious GC identifers: GC12M056406 GC12M055156 |
Summaries
for AGAP2 gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
Entrez Gene summary for AGAP2:
The protein encoded by this gene belongs to the centaurin gamma-like family. It mediates anti-apoptotic effects ofnerve growth factor by activating nuclear phosphoinositide 3-kinase. It is overexpressed in cancer cells, and promotescancer cell invasion. Alternatively spliced transcript variants encoding different isoforms have been described forthis gene. (provided by RefSeq, Aug 2011)
UniProtKB/Swiss-Prot: AGAP2_HUMAN, Q99490Function: GTPase-activating protein (GAP) for ARF1 and ARF5, which also shows strong GTPase activity. Isoform 1participates in the prevention of neuronal apoptosis by enhancing PI3 kinase activity. It aids the coupling ofmetabotropic glutamate receptor 1 (GRM1) to cytoplasmic PI3 kinase by interacting with Homer scaffolding proteins, andalso seems to mediate anti-apoptotic effects of NGF by activating nuclear PI3 kinase. Isoform 2 does not stimulate PI3kinase but may protect cells from apoptosis by stimulating Akt. It also regulates the adapter protein 1(AP-1)-dependent trafficking of proteins in the endosomal system. It seems to be oncogenic. It is overexpressed incancer cells, prevents apoptosis and promotes cancer cell invasion
Gene Wiki entry for AGAP2 (CENTG1)
|
Genomic Views
for AGAP2 gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000012.11 NC_018923.1 NT_029419.12
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the AGAP2 gene promoter:
AP-1 ATF-2 c-Jun
Other transcription factors
Search SABiosciences Chromatin IP Primers for AGAP2
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat AGAP2 |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 12q14.1 Ensembl cytogenetic band: 12q14.1 HGNC cytogenetic band: 12q13.2AGAP2 Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 12 GeneLoc Exon Structure GeneLoc location for GC12M058118: view genomic region
(about GC identifiers)
Start:
|
58,118,981 bp from pter |
End:
|
58,135,940 bp from pter |
Size:
|
16,960 bases |
Orientation:
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minus strand |
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Proteins
for AGAP2 gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: AGAP2_HUMAN, Q99490 (See
protein sequence)Recommended Name: Arf-GAP with GTPase, ANK repeat and PH domain-containing protein 2 Size: 1192 amino acids; 124674 Da
Subunit: Isoform 1 interacts with EPB41L1, PLCG1, NF2, HOMER1 and HOMER2 (By similarity). Isoform 2 interacts withactivated AKT1 in the presence of guanine nucleotides, and with the AP-1 complex
Subcellular location: Isoform 1: Cytoplasm. Nucleus
Subcellular location: Isoform 2: Cytoplasm
Sequence caution: Sequence=BAA11484.2; Type=Erroneous initiation;
3 PDB 3D structures from  and Proteopedia  for AGAP2:2BMJ (3D)
2IWR (3D)
2RLO (3D)
Secondary accessions: A8K9F7 O00578 Q548E0 Q8IWU3Alternative splicing: 2 isoforms: Q99490-1 Q99490-2 (Phosphorylated by FYN)Explore the universe of human proteins at neXtProt for AGAP2: NX_Q99490
Post-translational modifications:
Isoform PIKE-A is phosphorylated at Tyr-682 and Tyr-774 by FYN, preventing its apoptotic cleavage1
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_Q99490
AGAP2 Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins (2 alternative transcripts):
NP_001116244.1 NP_055585.1
ENSEMBL proteins: ENSP00000328160 ENSP00000257897 ENSP00000449241 ENSP00000446683 Reactome Protein details: Q99490
Human Recombinant Protein Products:
Gene Ontology (GO): 4 cellular component terms (GO ID links to tree view): About this table
AGAP2 for ontologies About GeneDecksing
AGAP2 Antibody Products:
Assay Products for AGAP2: |
Protein
Domains /
Families
for AGAP2 gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
AGAP2 for domains About GeneDecksing
5/6 InterPro domains/families (see all 6):Graphical View of Domain Structure for InterPro Entry Q99490ProtoNet protein and cluster: Q99490 4 Blocks protein families: IPB001164 HIV Rev interacting protein signature IPB001849 Pleckstrin-like IPB002110 Ankyrin repeat signature IPB013684 Miro-like
UniProtKB/Swiss-Prot: AGAP2_HUMAN, Q99490Domain: G domain binds GTP and has GTPase activityDomain: Arf-GAP domain interacts with G domain and may regulate its GTPase activityDomain: Although both PH domains of isoforms 1 and 2 bind phospholipids, they differently regulate subcellularlocation. PH domain of isoform 1 directs the protein to the nucleus, but PH domain of isoform 2 directs it to thecytosol. PH domain of isoform 2 is required for binding to AP-1Similarity: Belongs to the centaurin gamma-like familySimilarity: Contains 2 ANK repeatsSimilarity: Contains 1 Arf-GAP domainSimilarity: Contains 1 PH domain |
Function
for AGAP2 gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Function Summary:
UniProtKB/Swiss-Prot: AGAP2_HUMAN, Q99490Function: GTPase-activating protein (GAP) for ARF1 and ARF5, which also shows strong GTPase activity. Isoform 1participates in the prevention of neuronal apoptosis by enhancing PI3 kinase activity. It aids the coupling ofmetabotropic glutamate receptor 1 (GRM1) to cytoplasmic PI3 kinase by interacting with Homer scaffolding proteins, andalso seems to mediate anti-apoptotic effects of NGF by activating nuclear PI3 kinase. Isoform 2 does not stimulate PI3kinase but may protect cells from apoptosis by stimulating Akt. It also regulates the adapter protein 1(AP-1)-dependent trafficking of proteins in the endosomal system. It seems to be oncogenic. It is overexpressed incancer cells, prevents apoptosis and promotes cancer cell invasionEnzyme regulation: GAP activity is stimulated by phosphatidylinositol 4,5-bisphosphate (PIP2) and, to a lesser extent,by phosphatidylinositol 3,4,5-trisphosphate (PIP3). Phosphatidic acid potentiates PIP2 stimulation
Clone
Products: |  | Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore | |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for AGAP2 (see all 3)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for AGAP2 (see all 2)
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling 
| |  | GenScript: all cDNA clones in your preferred vector (see all 2): AGAP2 (NM_014770) | |  | Browse Sino Biological Human cDNA Clones | |  | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for AGAP2 | |  | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat AGAP2 |
In Situ Assay
Products: |
 | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for AGAP2 |
Gene Ontology (GO): 5/7 molecular function terms (GO ID links to tree view) (see all 7): About this table
AGAP2 for ontologies About GeneDecksing
5 GenomeRNAi human phenotypes for AGAP2:
Animal Models:
Mouse knock-out Agap2tm1.1Kye for AGAP2
5 MGI mutant phenotypes (inferred from 2 alleles ) (MGI details for Agap2):
AGAP2 for phenotypes About GeneDecksing
|
Pathways & Interactions
for AGAP2 gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Unified GeneCards pathways - 5/6 super-pathways (see all 6) About this table
See pathways by source
| Super-pathway | contained gene-specific pathways |
|---|
| 1 | Axon guidance | | | 2 | Development HGF signaling pathway | | | 3 | Trk receptor signaling mediated by PI3K and PLC-gamma | | | 4 | Endocytosis | | | 5 | Netrin-1 signaling | |
Pathway sources
See GeneCards unified pathways
Show all pathways
1 EMD Millipore Pathway for AGAP2
1  GeneGo (Thomson Reuters) Pathway for AGAP2
2  BioSystems Pathways for AGAP2
3 
Reactome Pathways for AGAP2
1 
Kegg Pathway (Kegg details for AGAP2):
AGAP2 for pathways About GeneDecksing
Interactions:
SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for AGAP2
STRING Interaction
Network Preview (showing 5 interactants - click image to see 19)
5/23 Interacting proteins for AGAP2 (Q994902, 3 ENSP000003281604) via UniProtKB, MINT, STRING, and/or I2D (see all 23)About this table
Gene Ontology (GO): 5/12 biological process terms (GO ID links to tree view) (see all 12): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0001934 | positive regulation of protein phosphorylation |
-- | -- | | GO:0007264 | small GTPase mediated signal transduction |
IEA | -- | | GO:0007411 | axon guidance |
TAS | -- | | GO:0015031 | protein transport |
IEA | -- | | GO:0032312 | regulation of ARF GTPase activity |
IEA | -- |
AGAP2 for ontologies About GeneDecksing
|
Drugs & Compounds
for AGAP2 gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
 Browse Tocris compounds for AGAP2
10/13 HMDB Compounds for AGAP2 (see all 13) About this table
Search CenterWatch for drugs/clinical trials and news about AGAP2
|
Transcripts
for AGAP2 gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for AGAP2 gene (2 alternative transcripts): NM_001122772.2 NM_014770.3 Unigene Cluster for AGAP2: ArfGAP with GTPase domain, ankyrin repeat and PH domain 2 Hs.302435 [show with all ESTs]Unigene Representative Sequence: NM_0011227724 Ensembl transcripts including schematic representations, and UCSC links where relevant: ENST00000328568(uc001spq.3 uc001spp.3) ENST00000257897(uc001spr.3)
ENST00000547588 ENST00000549129
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for AGAP2 (see all 3)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for AGAP2 (see all 2)
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript: all cDNA clones in your preferred vector (see all 2): AGAP2 (NM_014770) | | | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for AGAP2 | | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat AGAP2 |
Additional cDNA sequence: AF384128.1 AF413077.1 AK122827.1 AK292672.1 AY128689.1 BC028020.1 D79989.1 6 DOTS entries: DT.110116 DT.100781647 DT.99999099 DT.100727113 DT.92428865 DT.97843575 24/67 AceView cDNA sequences (see all 67): AL120358 AF384128 NM_014770 BQ935205 BU198063 AL560115 BC028020 AA939069 D79989 AA772779 CR625050 AI948875 AF413077 BU198064 AK122827 AL134787 AW016402 AI372021 BE551002 BV205580 AI708908 BX105563 AL118974 BE670674
GeneLoc Exon Structure
3 Alternative Splicing Database (ASD) splice patterns (SP) for AGAP2 About this scheme
| ExUns: | 1 | ^ | 2a | · | 2b | ^ | 3 | ^ | 4 | ^ | 5 | ^ | 6 | ^ | 7 | ^ | 8 | ^ | 9 | ^ | 10 | ^ | 11 | ^ | 12 | ^ | 13 | ^ | 14 | ^ | 15 | ^ | 16 | ^ | 17 | ^ | 18 | ^ | 19 | ^ | 20a | · | 20b | · | 20c |
|---|
|
| SP1: | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | |
| SP2: | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | |
| SP3: | | | - | | - | | | | | | | | | | | | | | | | | | | | | | | | | | - | | | | | | | | | | | | | | | |
ECgene alternative splicing isoforms for AGAP2
|
Expression
for AGAP2 gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| AGAP2 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: GGGATGGGGG
About this image
See AGAP2 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for AGAP2
SOURCE GeneReport for Unigene cluster: Hs.302435
UniProtKB/Swiss-Prot: AGAP2_HUMAN, Q99490Tissue specificity: Isoform 1 is brain-specific. Isoform 2 is ubiquitously expressed, with highest levels in brain andheart
SABiosciences Custom PCR Arrays for AGAP2
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for AGAP2
Browse OriGene validated miRNA SYBR primer pairs
| | | SABiosciences RT2 qPCR Primer Assay in human, mouse, rat AGAP2 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat AGAP2 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat AGAP2 | In Situ
Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for AGAP2 |
Orthologs
for AGAP2 gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
This gene was present in the common ancestor of animals.
Orthologs for AGAP2 gene from 3/17 species (see all 17) About this table
| Organism |
Taxonomic
classification |
Gene |
Description |
Human
Similarity |
Orthology
Type |
Details |
lizard
(Anolis carolinensis) |
Reptilia |
AGAP26 |
-- |
66(a) |
1 ↔ 1 |
2(66469382-66556083) |
zebrafish
(Danio rerio) |
Actinopterygii |
zgc:1537791 |
zgc:153779 |
60.37(n)
59.65(a) |
|
565109 NM_001080018.1 NP_001073487.1 |
fruit fly
(Drosophila melanogaster) |
Insecta |
cenG1A6 |
centaurin gamma 1A |
32(a) |
1 → many |
2L(13835567-13898715) |
ENSEMBL Gene Tree for AGAP2 (if available)
TreeFam Gene Tree for AGAP2 (if available) |
Paralogs
for AGAP2 gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| Paralogs for AGAP2 gene
- AGAP52 AGAP62 ASAP12 ACAP22 ARAP32 GIT22 ACAP32 ARAP12
- ASAP22 AGAP32 GIT12 ARAP22 AGAP42 AGAP12 AGAP82 ACAP12
- AGAP72 AGAP102 AGAP92 ASAP32
17 SIMAP similar genes for AGAP2 using alignment to 4 protein entries: AGAP2_HUMAN (see all proteins):CENTG2 AGAP1 DKFZp761E2216 CENTG3 AGAP3 AGAP10
AGAP11 CTGLF11P ARFGAP3 AGAP8 AGAP4 AGAP5
AGAP9 AGAP6 AGAP7 FLJ00312 ARFGAP1
AGAP2 for paralogs About GeneDecksing
|
Genomic Variants
for AGAP2 gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr 12 pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
|---|
HapMap Linkage Disequilibrium report for AGAP2 (58118981 - 58135940 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV) variations for AGAP2: -- | SABiosciences Cancer Mutation PCR Assays |
| | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing AGAP2 |
|
Disorders
/ Diseases
for AGAP2 gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database, Novoseek,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
AGAP2 for disorders About GeneDecksing
OMIM gene information: 605476
OMIM disorders: --
10  diseases for AGAP2: About MalaCardsanisakiasis diphyllobothriasis lymphosarcoma myxoma
prostate cancer, progression of prostate cancer prostatitis glioblastoma
malaria neuronitis
3 diseases from the University of Copenhagen DISEASES database for AGAP2:Diphyllobothriasis Lymphosarcoma Anisakiasis 1 Novoseek disease relationship for AGAP2 gene About this table
| Disease |
-log (P-Val) |
Hits |
PubMed IDs for Articles with Shared Sentences (# sentences) |
| cancer |
28.5 |
3 |
19318351 (1), 20419274 (1), 17367500 (1) |
Human Genome Epidemiology (HuGE) Navigator: AGAP2 (2 documents)
Export disorders for AGAP2 gene to outside databases
|
Publications
for AGAP2 gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for AGAP2 gene, integrated from 9 sources (see all 41):
(articles sorted by number of sources associating them with AGAP2) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- The Arf GAPs AGAP1 and AGAP2 distinguish between the adaptor protein complexes AP-1 and AP-3. (PubMed id 16079295)1, 2, 9 Nie Z.... Randazzo P.A. (2005)
- Genetic alteration and expression of the phosphoinositol-3-kinase/Akt pathway genes PIK3CA and PIKE in human glioblastomas. (PubMed id 16150119)1, 2, 9 Knobbe C.B.... Reifenberger G. (2005)
- The centaurin gamma-1 GTPase-like domain functions as an NTPase. (PubMed id 17037982)1, 2, 9 Soundararajan M....Doyle D.A. (2007)
- PIKE (phosphatidylinositol 3-kinase enhancer)-A GTPase stimulates Akt activity and mediates cellular invasion. (PubMed id 14761976)1, 2, 9 Ahn J.-Y.... Ye K. (2004)
- Split pleckstrin homology domain-mediated cytoplasmic-nuclear localization of PI3-kinase enhancer GTPase. (PubMed id 18371979)1, 2 Yan J....Zhang M. (2008)
- Src-family tyrosine kinase fyn phosphorylates phosphatidylinositol 3-kinase enhancer-activating Akt, preventing its apoptotic cleavage and promoting cell survival. (PubMed id 16841086)1, 2 Tang X....Ye K. (2007)
- Phosphoinositol lipids bind to phosphatidylinositol 3 (PI3)-kinase enhancer GTPase and mediate its stimulatory effect on PI3-kinase and Akt signalings. (PubMed id 16263930)1, 2 Hu Y.... Ye K. (2005)
- PIKE-A is amplified in human cancers and prevents apoptosis by up- regulating Akt. (PubMed id 15118108)1, 2 Ahn J.-Y.... Ye K. (2004)
- Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (2004)
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
|
External Searches for AGAP2 gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
|
|
Genome Databases showing AGAP2 gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing AGAP2 gene
(According to HUGE)
About This Section
| |
Specialized Databases showing AGAP2 gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
|
About This Section
| Patent Information for AGAP2 gene:
Search GeneIP for patents involving AGAP2
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
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Products
for AGAP2 gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences),
In Situ Hybridization Assays from
Advanced Cell Diagnostics
About This Section
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| | |  | OriGene Antibodies for AGAP2 | | OriGene shRNA RFP for AGAP2 | | | OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for AGAP2 | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for AGAP2 | | | OriGene Protein Over-expression Lysate for AGAP2 | | Browse OriGene Fluorogenic Cell Assay Kits | | | OriGene siRNA for AGAP2 | | OriGene 3'-UTR Clone for AGAP2 | | | OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for AGAP2 | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for AGAP2 | | | Browse OriGene GFP tagged cDNA clones in CMV expression vector | | Browse OriGene MicroRNA Expression Plasmids | | | Browse OriGene basic RS shRNAs | | Browse OriGene validated miRNA SYBR primer pairs | | | Browse OriGene full length recombinant human proteins expressed in human HEK293 cells | | OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling | | | OriGene Custom Antibody Services for AGAP2 | | OriGene Custom Protein Services for AGAP2 | | | OriGene Custom Immunoassay Development | | |
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| | | QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat AGAP2 | | | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing AGAP2 | | | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat AGAP2 | | | QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat AGAP2 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat AGAP2 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat AGAP2 |
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| | | | Search Tocris compounds for AGAP2 |
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 | | | | | | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for AGAP2 |
|  |  |  | | | | ThermoFisher Antibodies for AGAP2 |
| | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat AGAP2 |
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