Set Analyses:
Advanced Search

Advanced Search

 
Search By
Section (entire)
for


 
or upload a file of gene symbols


Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

AGAP2 Gene

protein-coding   GIFtS: 63
GCID: GC12M058118

ArfGAP With GTPase Domain, Ankyrin Repeat And PH Domain...

(Previous names: centaurin, gamma 1)
(Previous symbol: CENTG1)
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
ArfGAP With GTPase Domain, Ankyrin Repeat And PH Domain 21 2     GTP-Binding And GTPase Activating Protein 22
CENTG11 2 3     Phosphatidylinositol-3-Kinase Enhancer2
PIKE2 3 5     Phosphoinositide 3-Kinase Enhancer2
Centaurin, Gamma 11 2     AGAP-23
Phosphatidylinositol 3-Kinase Enhancer2 3     Centaurin-gamma-13
GGAP22 3     Cnt-g13
Arf GAP With GTP-Binding Protein-Like, ANK Repeat And PH Domains 22     KIAA01673
Arf-GAP With GTPase, ANK Repeat And PH Domain-Containing Protein 22     GTP-Binding And GTPase-Activating Protein 23
cnt-g12     

External Ids:    HGNC: 169211   Entrez Gene: 1169862   Ensembl: ENSG000001354397   OMIM: 6054765   UniProtKB: Q994903   

Export aliases for AGAP2 gene to outside databases

Previous GC identifers: GC12M056406 GC12M055156


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for AGAP2 Gene:
The protein encoded by this gene belongs to the centaurin gamma-like family. It mediates anti-apoptotic effects of
nerve growth factor by activating nuclear phosphoinositide 3-kinase. It is overexpressed in cancer cells, and
promotes cancer cell invasion. Alternatively spliced transcript variants encoding different isoforms have been
described for this gene. (provided by RefSeq, Aug 2011)

GeneCards Summary for AGAP2 Gene: 
AGAP2 (ArfGAP with GTPase domain, ankyrin repeat and PH domain 2) is a protein-coding gene. Diseases associated with AGAP2 include anisakiasis, and diphyllobothriasis, and among its related super-pathways are Axon guidance and Development Prolactin receptor signaling. GO annotations related to this gene include ARF GTPase activator activity and GTP binding. An important paralog of this gene is AGAP5.

UniProtKB/Swiss-Prot: AGAP2_HUMAN, Q99490
Function: GTPase-activating protein (GAP) for ARF1 and ARF5, which also shows strong GTPase activity. Isoform 1
participates in the prevention of neuronal apoptosis by enhancing PI3 kinase activity. It aids the coupling of
metabotropic glutamate receptor 1 (GRM1) to cytoplasmic PI3 kinase by interacting with Homer scaffolding
proteins, and also seems to mediate anti-apoptotic effects of NGF by activating nuclear PI3 kinase. Isoform 2
does not stimulate PI3 kinase but may protect cells from apoptosis by stimulating Akt. It also regulates the
adapter protein 1 (AP-1)-dependent trafficking of proteins in the endosomal system. It seems to be oncogenic. It
is overexpressed in cancer cells, prevents apoptosis and promotes cancer cell invasion

Gene Wiki entry for AGAP2 (CENTG1) Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000012.11  NT_029419.12  NC_018923.2  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the AGAP2 gene promoter:
         AP-1   ATF-2   c-Jun   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmids (see all 2): AGAP2 promoter sequence
   Search SABiosciences Chromatin IP Primers for AGAP2

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat AGAP2


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 12q14.1   Ensembl cytogenetic band:  12q14.1   HGNC cytogenetic band: 12q13.2

AGAP2 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
AGAP2 gene location

GeneLoc information about chromosome 12         GeneLoc Exon Structure

GeneLoc location for GC12M058118:  view genomic region     (about GC identifiers)

Start:
58,118,980 bp from pter      End:
58,135,940 bp from pter
Size:
16,961 bases      Orientation:
minus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: AGAP2_HUMAN, Q99490 (See protein sequence)
Recommended Name: Arf-GAP with GTPase, ANK repeat and PH domain-containing protein 2  
Size: 1192 amino acids; 124674 Da
Subunit: Isoform 1 interacts with EPB41L1, PLCG1, NF2, HOMER1 and HOMER2 (By similarity). Isoform 2 interacts with
activated AKT1 in the presence of guanine nucleotides, and with the AP-1 complex
Subcellular location: Isoform 1: Cytoplasm. Nucleus
Subcellular location: Isoform 2: Cytoplasm
Sequence caution: Sequence=BAA11484.2; Type=Erroneous initiation;
3 PDB 3D structures from and Proteopedia for AGAP2:
2BMJ (3D)        2IWR (3D)        2RLO (3D)    
Secondary accessions: A8K9F7 O00578 Q548E0 Q8IWU3
Alternative splicing: 2 isoforms:  Q99490-1   Q99490-2   (Phosphorylated by FYN)

Explore the universe of human proteins at neXtProt for AGAP2: NX_Q99490

Explore proteomics data for AGAP2 at MOPED 

Post-translational modifications:

  • UniProtKB: Isoform PIKE-A is phosphorylated at Tyr-682 and Tyr-774 by FYN, preventing its apoptotic cleavage
  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_Q99490

  • AGAP2 Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    AGAP2 Protein Expression
    REFSEQ proteins (2 alternative transcripts): 
    NP_001116244.1  NP_055585.1  

    ENSEMBL proteins: 
     ENSP00000328160   ENSP00000257897   ENSP00000449241   ENSP00000446683  
    Reactome Protein details: Q99490
    Human Recombinant Protein Products for AGAP2: 
    Browse Purified and Recombinant Proteins at EMD Millipore
    Browse R&D Systems for human recombinant proteins
    Browse recombinant and purified proteins available from Enzo Life Sciences
    Browse OriGene full length recombinant human proteins expressed in human HEK293 cells
    OriGene Protein Over-expression Lysate for AGAP2
    OriGene Custom MassSpec 
    OriGene Custom Protein Services for AGAP2
    GenScript Custom Purified and Recombinant Proteins Services for AGAP2
    Novus Biologicals AGAP2 Proteins
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates 
    Browse ProSpec Recombinant Proteins
    Browse Proteins at Cloud-Clone Corp. 

    Gene Ontology (GO): 5 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005622intracellular ----
    GO:0005634nucleus ISS11136977
    GO:0005730nucleolus IDA--
    GO:0005739mitochondrion IDA--
    GO:0016020membrane ----

    AGAP2 for ontologies           About GeneDecksing



    AGAP2 Antibody Products: 
    EMD Millipore Mono- and Polyclonal Antibodies for the study of AGAP2
    Browse R&D Systems for Antibodies
    OriGene Antibodies for AGAP2
    OriGene Custom Antibody Services for AGAP2
    GenScript Custom Superior Antibodies Services for AGAP2
    Novus Biologicals AGAP2 Antibodies
    Abcam antibodies for AGAP2
    Browse Antibodies at Cloud-Clone Corp. 
    ThermoFisher Antibodies for AGAP2
    LSBio Antibodies in human, mouse, rat for AGAP2 

    Assay Products for AGAP2: 
    Browse Kits and Assays available from EMD Millipore
    OriGene Custom Assay Services for AGAP2
    Browse R&D Systems for biochemical assays
    GenScript Custom Assay Services for AGAP2
    Browse Enzo Life Sciences for kits & assays
    Browse ELISAs at Cloud-Clone Corp. 
    Browse CLIAs at Cloud-Clone Corp.


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    HGNC Gene Families: 
    PLEKH: Pleckstrin homology (PH) domain containing
    ANKRD: Ankyrin repeat domain containing
    ArfGAP: ADP-ribosylation factor GTPase activating proteins

    5/7 InterPro protein domains (see all 7):
     IPR027417 P-loop_NTPase
     IPR013684 MIRO-like
     IPR001849 Pleckstrin_homology
     IPR001164 ArfGAP
     IPR020683 Ankyrin_rpt-contain_dom

    Graphical View of Domain Structure for InterPro Entry Q99490

    ProtoNet protein and cluster: Q99490

    4 Blocks protein domains:
    IPB001164 HIV Rev interacting protein signature
    IPB001849 Pleckstrin-like
    IPB002110 Ankyrin repeat signature
    IPB013684 Miro-like


    UniProtKB/Swiss-Prot: AGAP2_HUMAN, Q99490
    Domain: G domain binds GTP and has GTPase activity
    Domain: Arf-GAP domain interacts with G domain and may regulate its GTPase activity
    Domain: Although both PH domains of isoforms 1 and 2 bind phospholipids, they differently regulate subcellular
    location. PH domain of isoform 1 directs the protein to the nucleus, but PH domain of isoform 2 directs it to the
    cytosol. PH domain of isoform 2 is required for binding to AP-1
    Similarity: Belongs to the centaurin gamma-like family
    Similarity: Contains 2 ANK repeats
    Similarity: Contains 1 Arf-GAP domain
    Similarity: Contains 1 PH domain


    AGAP2 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: AGAP2_HUMAN, Q99490
    Function: GTPase-activating protein (GAP) for ARF1 and ARF5, which also shows strong GTPase activity. Isoform 1
    participates in the prevention of neuronal apoptosis by enhancing PI3 kinase activity. It aids the coupling of
    metabotropic glutamate receptor 1 (GRM1) to cytoplasmic PI3 kinase by interacting with Homer scaffolding
    proteins, and also seems to mediate anti-apoptotic effects of NGF by activating nuclear PI3 kinase. Isoform 2
    does not stimulate PI3 kinase but may protect cells from apoptosis by stimulating Akt. It also regulates the
    adapter protein 1 (AP-1)-dependent trafficking of proteins in the endosomal system. It seems to be oncogenic. It
    is overexpressed in cancer cells, prevents apoptosis and promotes cancer cell invasion
    Enzyme regulation: GAP activity is stimulated by phosphatidylinositol 4,5-bisphosphate (PIP2) and, to a lesser
    extent, by phosphatidylinositol 3,4,5-trisphosphate (PIP3). Phosphatidic acid potentiates PIP2 stimulation

         Gene Ontology (GO): 5/8 molecular function terms (GO ID links to tree view) (see all 8):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003924GTPase activity ----
    GO:0005515protein binding IPI--
    GO:0005525GTP binding IEA--
    GO:0005543phospholipid binding IEA--
    GO:0008060ARF GTPase activator activity IEA--
         
    AGAP2 for ontologies           About GeneDecksing


    Phenotypes:
         5 GenomeRNAi human phenotypes for AGAP2:
     Altered focal adhesion (FA) or  Decreased Tat-dependent transc  Decreased Wnt reporter activit  Decreased p24 protein expressi 
     Increased gamma-H2AX phosphory 

         5 MGI mutant phenotypes (inferred from 2 alleles(MGI details for Agap2):
     endocrine/exocrine gland  growth/size  homeostasis/metabolism  integument  liver/biliary system 

    AGAP2 for phenotypes           About GeneDecksing

    Animal Models:
         MGI mouse knock-out Agap2tm1.1Kye for AGAP2

       inGenious Targeting Laboratory - Custom generated mouse model solutions for AGAP2 
       inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for AGAP2

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for AGAP2 
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for AGAP2 

    miRNA
    Products:
        
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat AGAP2
    8/63 QIAGEN miScript miRNA Assays for microRNAs that regulate AGAP2 (see all 63):
    hsa-miR-1321 hsa-miR-3194-5p hsa-miR-136 hsa-miR-520e hsa-miR-302d hsa-miR-1914* hsa-miR-513a-5p hsa-miR-624
    SwitchGear 3'UTR luciferase reporter plasmidAGAP2 3' UTR sequence
    Inhib. RNA
    Products:
        
    Browse for Gene Knock-down Tools from EMD Millipore
    OriGene RNAi products in human, mouse, rat for AGAP2
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat AGAP2

    Gene Editing
    Products:
    DNA2.0 Custom Protein Engineering Service for AGAP2
    Sirion Biotech Customized adenovirus for overexpression of AGAP2

    Clone
    Products:
         
    Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
    OriGene clones in human, mouse for AGAP2 (see all 13)
    OriGene ORF clones in mouse, rat for AGAP2
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector (see all 2): AGAP2 (NM_014770)
    Browse Sino Biological Human cDNA Clones
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for AGAP2
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat AGAP2
    Sirion Biotech Customized lentivirus for stable overexpression of AGAP2 
                         Customized lentivirus expression plasmids for stable overexpression of AGAP2 

    Cell Line
    Products:
         
    GenScript Custom overexpressing Cell Line Services for AGAP2
    Search LifeMap BioReagents cell lines for AGAP2
    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for AGAP2


    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section

    SuperPaths for AGAP2 About   (see all 6)                                                                                              See pathways by source

    SuperPathContained pathways About
    1Axon guidance
    Axon guidance0.69
    Developmental Biology0.69
    2Development Prolactin receptor signaling
    Prolactin Signaling Pathway0.39
    3Development HGF signaling pathway
    Apoptosis and survival NGF signaling pathway0.36
    4Netrin-1 signaling
    Netrin-1 signaling0.33
    5Trk receptor signaling mediated by PI3K and PLC-gamma
    Trk receptor signaling mediated by PI3K and PLC-gamma

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    1 EMD Millipore Pathway for AGAP2
        Apoptosis and survival NGF signaling pathway


    1 GeneGo (Thomson Reuters) Pathway for AGAP2
        Apoptosis and survival NGF signaling pathway

    2 BioSystems Pathways for AGAP2
        Prolactin Signaling Pathway
    Trk receptor signaling mediated by PI3K and PLC-gamma

    3        Reactome Pathways for AGAP2
        Developmental Biology
    Netrin-1 signaling
    Axon guidance


    1         Kegg Pathway  (Kegg details for AGAP2):
        Endocytosis


    AGAP2 for pathways           About GeneDecksing

    Interactions:

        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for AGAP2

    STRING Interaction Network Preview (showing 5 interactants - click image to see 19)

    5/23 Interacting proteins for AGAP2 (Q994902, 3 ENSP000003281604) via UniProtKB, MINT, STRING, and/or I2D (see all 23)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    STAT5AP422292, 3, ENSP000003412084MINT-7760983 MINT-7760966 MINT-7761049 I2D: score=1 STRING: ENSP00000341208
    INSRP062132, 3, ENSP000003038304MINT-8204673 MINT-8204689 I2D: score=2 STRING: ENSP00000303830
    HOMER1Q86YM73, ENSP000003343824I2D: score=4 STRING: ENSP00000334382
    EPB41L1Q9H4G03, ENSP000003371684I2D: score=3 STRING: ENSP00000337168
    HOMER2Q9NSB83, ENSP000003056324I2D: score=3 STRING: ENSP00000305632
    About this table

    Gene Ontology (GO): 5/15 biological process terms (GO ID links to tree view) (see all 15):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006184GTP catabolic process ----
    GO:0007165signal transduction ----
    GO:0007264small GTPase mediated signal transduction IEA--
    GO:0007411axon guidance TAS--
    GO:0015031protein transport IEA--

    AGAP2 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section

    AGAP2 for compounds           About GeneDecksing

    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for AGAP2

    10/13 HMDB Compounds for AGAP2 (see all 13)    About this table
    CompoundSynonyms CAS #PubMed Ids
    Guanosine triphosphate5'-GTP (see all 10)86-01-1--
    PA(16:0/16:0)Dipalmitoylphosphatidic acid (see all 25)7091-44-3--
    PA(16:0/18:1(11Z))PA(16:0/18:1n7) (see all 10)----
    PA(16:0/18:1(9Z))PA(16:0/18:1n9) (see all 10)----
    PA(16:0/18:2(9Z,12Z))PA(34:2) (see all 10)----
    PA(16:0e/18:0)2-octadecanoyl-1-hexadecyl-sn-glycero-3-phosphate ;PA(o-16:0/18:0) ----
    PA(18:0/18:2(9Z,12Z))PA(36:2) (see all 10)----
    PA(18:1(11Z)/18:1(11Z))PA(36:2) (see all 10)----
    PA(18:1(11Z)/18:1(9Z))PA(36:2) (see all 10)----
    PA(18:1(9Z)/18:1(11Z))PA(36:2) (see all 10)----

    1 PharmGKB related drug/compound annotation for AGAP2 gene    About this table
    Drug/compound PharmGKB Annotation
    somatropin recombinantCA  

    Search CenterWatch for drugs/clinical trials and news about AGAP2

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for AGAP2 gene (2 alternative transcripts): 
    NM_001122772.2  NM_014770.3  

    Unigene Cluster for AGAP2:

    ArfGAP with GTPase domain, ankyrin repeat and PH domain 2
    Hs.302435  [show with all ESTs]
    Unigene Representative Sequence: NM_001122772
    4 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000328568(uc001spq.3 uc001spp.3) ENST00000257897(uc001spr.3)
    ENST00000547588 ENST00000549129
    miRNA
    Products:
         
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat AGAP2
    8/63 QIAGEN miScript miRNA Assays for microRNAs that regulate AGAP2 (see all 63):
    hsa-miR-1321 hsa-miR-3194-5p hsa-miR-136 hsa-miR-520e hsa-miR-302d hsa-miR-1914* hsa-miR-513a-5p hsa-miR-624
    SwitchGear 3'UTR luciferase reporter plasmidAGAP2 3' UTR sequence
    Inhib. RNA
    Products:
         
    Browse for Gene Knock-down Tools from EMD Millipore
    OriGene RNAi products in human, mouse, rat for AGAP2
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat AGAP2
    Clone
    Products:
         
    OriGene clones in human, mouse for AGAP2 (see all 13)
    OriGene ORF clones in mouse, rat for AGAP2
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector (see all 2): AGAP2 (NM_014770)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for AGAP2
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat AGAP2
    Sirion Biotech Customized lentivirus for stable overexpression of AGAP2 
                         Customized lentivirus expression plasmids for stable overexpression of AGAP2 
    Primer
    Products:
        
    OriGene qPCR primer pairs and template standards for AGAP2
    OriGene qSTAR qPCR primer pairs in human, mouse for AGAP2
    SABiosciences RT2 qPCR Primer Assay in human, mouse, rat AGAP2
      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat AGAP2
      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat AGAP2

    Additional mRNA sequence: 

    AF384128.1 AF413077.1 AK122827.1 AK292672.1 AY128689.1 BC028020.1 D79989.1 

    8 DOTS entries:

    DT.110116  DT.100781647  DT.99999099  DT.100781650  DT.100727113  DT.97843575  DT.100835143  DT.92428865 

    24/67 AceView cDNA sequences (see all 67):

    NM_014770 BU198063 AA939069 D79989 AL560115 AL120358 AI948875 CR625050 
    AA772779 AK122827 BC028020 BQ935205 AF384128 AF413077 BU198064 AL134787 
    BE670674 BV205580 BG825364 AL118974 AI372021 BX105563 BE551002 BE280072 

    GeneLoc Exon Structure

    3 Alternative Splicing Database (ASD) splice patterns (SP) for AGAP2    About this scheme

    ExUns: 1 ^ 2a · 2b ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11 ^ 12 ^ 13 ^ 14 ^ 15 ^ 16 ^ 17 ^ 18 ^ 19 ^ 20a · 20b · 20c
    SP1:                                                                                                                                          
    SP2:                                                                                                                                          
    SP3:        -     -                                                                             -                                             


    ECgene alternative splicing isoforms for AGAP2

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    AGAP2 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: GGGATGGGGG
    AGAP2 Expression
    About this image


    See AGAP2 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for AGAP2

    SOURCE GeneReport for Unigene cluster: Hs.302435

    UniProtKB/Swiss-Prot: AGAP2_HUMAN, Q99490
    Tissue specificity: Isoform 1 is brain-specific. Isoform 2 is ubiquitously expressed, with highest levels in brain
    and heart

        SABiosciences Custom PCR Arrays for AGAP2
    Primer
    Products:
    OriGene qPCR primer pairs and template standards for AGAP2
    OriGene qSTAR qPCR primer pairs in human, mouse for AGAP2
    SABiosciences RT2 qPCR Primer Assay in human, mouse, rat AGAP2
    QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat AGAP2
    QIAGEN QuantiFast Probe-based Assays in human, mouse, rat AGAP2
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for AGAP2

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of animals.

    Orthologs for AGAP2 gene from 5/11 species (see all 11)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Agap21 , 5 ArfGAP with GTPase domain, ankyrin repeat and PH domain more1, 5 90.01(n)1
    95.61(a)1
      10 (74.50 cM)5
    2164391  NM_001033263.41  NP_001028435.11 
     1270789075 
    lizard
    (Anolis carolinensis)
    Reptilia AGAP26
    ACAP36
    Uncharacterized protein
    52(a)
    23(a)
    1 ↔ 1
    possible ortholog
    2(66469382-66556664)
    GL344927.1(9483-14636)
    zebrafish
    (Danio rerio)
    Actinopterygii zgc:1537791 zgc:153779 60.37(n)
    59.65(a)
      565109  NM_001080018.1  NP_001073487.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta cenG1A6
    centaurin gamma 1A
    33(a)
    1 → many
    2L(13835567-13898715)
    worm
    (Caenorhabditis elegans)
    Secernentea cnt-26
    Protein CNT-2, isoform b
    27(a)
    1 → many
    III(10655770-10677522)


    ENSEMBL Gene Tree for AGAP2 (if available)
    TreeFam Gene Tree for AGAP2 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for AGAP2 gene
    AGAP52  AGAP62  ASAP12  ARAP32  ACAP22  ACAP32  ASAP22  ARAP12  
    AGAP32  ARAP22  AGAP42  AGAP12  AGAP82  ACAP12  AGAP72  AGAP102  
    AGAP92  ASAP32  
    17 SIMAP similar genes for AGAP2 using alignment to 4 protein entries:     AGAP2_HUMAN (see all proteins):
    CENTG2    AGAP1    DKFZp761E2216    CENTG3    AGAP3    AGAP10
    AGAP11    CTGLF11P    ARFGAP3    AGAP8    AGAP4    AGAP5
    AGAP9    AGAP6    AGAP7    FLJ00312    ARFGAP1

    AGAP2 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/422 SNPs in AGAP2 are shown (see all 422)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 12 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    VAR_0264414
    A glioblastoma cell line4--see VAR_0264412 A V mis40--------
    VAR_0264454
    A glioblastoma cell line4--see VAR_0264452 S P mis40--------
    VAR_0361844
    A breast cancer sample4--see VAR_0361842 D Y mis40--------
    VAR_0264424
    A glioblastoma cell line4--see VAR_0264422 E V mis40--------
    VAR_0264384
    A glioblastoma cell line4--see VAR_0264382 V A mis40--------
    VAR_0361834
    A breast cancer sample4--see VAR_0361832 T A mis40--------
    VAR_0264444
    A sarcoma cell line4--see VAR_0264442 V M mis40--------
    VAR_0264394
    A sarcoma cell line4--see VAR_0264392 R G mis40--------
    VAR_0264434
    A glioblastoma cell line4--see VAR_0264432 N D mis40--------
    VAR_0264404
    ----see VAR_0264402 T I mis40--------

    HapMap Linkage Disequilibrium report for AGAP2 (58118980 - 58135940 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 10 variations for AGAP2:    About this table     
    Variant IDTypeSubtypePubMed ID
    nsv899121CNV Loss21882294
    nsv899123CNV Loss21882294
    nsv470296CNV Loss18288195
    nsv899122CNV Loss21882294
    nsv510601CNV Loss20534489
    nsv470297CNV Gain18288195
    nsv826384CNV Gain20364138
    nsv826383CNV Gain20364138
    nsv826386CNV Gain20364138
    nsv826385CNV Gain20364138

    SABiosciences Cancer Mutation PCR Assays
    SeqTarget long-range PCR primers for resequencing AGAP2
    DNA2.0 Custom Variant and Variant Library Synthesis for AGAP2

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    OMIM gene information: 605476    OMIM disorders: --

    9 diseases for AGAP2:    About MalaCards
    anisakiasis    diphyllobothriasis    lymphosarcoma    prostate cancer, progression of
    prostate cancer    glioblastoma    prostatitis    multiple sclerosis
    neuronitis

    3 diseases from the University of Copenhagen DISEASES database for AGAP2:
    Diphyllobothriasis     Anisakiasis     Lymphosarcoma

    AGAP2 for disorders           About GeneDecksing

    1 Novoseek inferred disease relationship for AGAP2 gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    cancer 28.5 3 19318351 (1), 20419274 (1), 17367500 (1)

    Genetic Association Database (GAD): AGAP2
    Human Genome Epidemiology (HuGE) Navigator: AGAP2 (2 documents)

    Export disorders for AGAP2 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for AGAP2 gene, integrated from 9 sources (see all 46):
    (articles sorted by number of sources associating them with AGAP2)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. The Arf GAPs AGAP1 and AGAP2 distinguish between the adaptor protein complexes AP-1 and AP-3. (PubMed id 16079295)1, 2, 9 Nie Z.... Randazzo P.A. (2005)
    2. Genetic alteration and expression of the phosphoinositol-3-kinase/Akt pathway genes PIK3CA and PIKE in human glioblastomas. (PubMed id 16150119)1, 2, 9 Knobbe C.B.... Reifenberger G. (2005)
    3. The centaurin gamma-1 GTPase-like domain functions as an NTPase. (PubMed id 17037982)1, 2, 9 Soundararajan M....Doyle D.A. (2007)
    4. PIKE (phosphatidylinositol 3-kinase enhancer)-A GTPase stimulates Akt activity and mediates cellular invasion. (PubMed id 14761976)1, 2, 9 Ahn J.-Y.... Ye K. (2004)
    5. Split pleckstrin homology domain-mediated cytoplasmic-nuclear localization of PI3-kinase enhancer GTPase. (PubMed id 18371979)1, 2 Yan J....Zhang M. (2008)
    6. Src-family tyrosine kinase fyn phosphorylates phosphatidylinositol 3-kinase enhancer-activating Akt, preventing its apoptotic cleavage and promoting cell survival. (PubMed id 16841086)1, 2 Tang X....Ye K. (2007)
    7. Phosphoinositol lipids bind to phosphatidylinositol 3 (PI3)-kinase enhancer GTPase and mediate its stimulatory effect on PI3-kinase and Akt signalings. (PubMed id 16263930)1, 2 Hu Y.... Ye K. (2005)
    8. PIKE-A is amplified in human cancers and prevents apoptosis by up- regulating Akt. (PubMed id 15118108)1, 2 Ahn J.-Y.... Ye K. (2004)
    9. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (2004)
    10. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 116986 HGNC: 16921 AceView: CENTG1 Ensembl:ENSG00000135439 euGenes: HUgn116986
    ECgene: AGAP2 Kegg: 116986 H-InvDB: AGAP2

    (According to HUGE)
    About This Section
    HUGE: KIAA0167

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for AGAP2 Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for AGAP2 Genetics and Cytogenetics in Oncology and Haematology

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for AGAP2 gene:
    Search GeneIP for patents involving AGAP2

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0 and Sirion Biotech, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Sirion Biotech, Cell lines from GenScript, and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
    About This Section

     Browse Kits and Assays available from EMD Millipore
     EMD Millipore Mono- and Polyclonal Antibodies for the study of AGAP2
     Browse for Gene Knock-down Tools from EMD Millipore
     Browse Small Molecules at EMD Millipore
     Browse Purified and Recombinant Proteins at EMD Millipore
     Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
     
     EMD Millipore Custom Antibody & Bulk Services
     EMD Millipore Preclinical / Clinical Development Services
     EMD Millipore Immunoassay Services
     EMD Millipore Target Screening & Profiling Services

      
     Browse Antibodies   Browse Cell Culture Products  
     Browse ELISAs   Browse Flow Cytometry Kits  
     Browse Primer Pairs   Browse Kinase Activity Assays/Reagents  
     Browse ELISpot Kits/Development Modules   Browse TFB/Immunoprecipitation Assays  
     Browse Apoptosis Detection Kits/Reagents   Browse Ubiquitin Proteasome Pathway (UPP) Assay Kits/Reagents  
     Browse DNA Damage/Repair Kits/Reagents   Browse Multiplex/Array Assay Kits/Reagents  
     Browse Cell Selection/Detection Kits/Reagents   Browse Secondary Antibodies/Controls/Staining Reagents  
     Browse Protease Activity Assays and Reagents   Browse Recombinant/Natural Proteins  
     Browse Stem Cell Products   Browse Tocris Biochemicals & Compounds  
     Browse cDNA Clones   Browse Proteome Profiler Antibody Arrays  
     OriGene Antibodies for AGAP2   OriGene RNAi products in human, mouse, rat for AGAP2  
     OriGene qPCR primer pairs and template standards for AGAP2   OriGene Protein Over-expression Lysate for AGAP2  
     OriGene Custom Mass Spec   OriGene clones in human, mouse for AGAP2  
     OriGene qSTAR qPCR primer pairs in human, mouse for AGAP2   Browse OriGene full length recombinant human proteins expressed in human HEK293 cells  
     OriGene ORF clones in mouse, rat for AGAP2   OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling  
     OriGene Custom Antibody Services for AGAP2   OriGene Custom Protein Services for AGAP2  

     
     
     QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat AGAP2
     QIAGEN SeqTarget long-range PCR primers for resequencing AGAP2
     QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat AGAP2
     QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat AGAP2
     QIAGEN QuantiFast Probe-based Assays in human, mouse, rat AGAP2
     QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat AGAP2
     GenScript Custom Purified and Recombinant Proteins Services for AGAP2 GenScript cDNA clones with any tag delivered in your preferred vector for AGAP2
     GenScript Custom Assay Services for AGAP2 GenScript Custom Superior Antibodies Services for AGAP2
     GenScript Custom overexpressing Cell Line Services for AGAP2 CloneReady with Over 120,000 Genes
     Gene Synthesis: Any Gene in Any Vector Vector-based siRNA and miRNA, Ready for Transfection
     Gene Mutant Library, Variants up to 10^11 Plasmid Preparation
     Custom Peptide Services
     Search for Antibodies & Assays

     Regulatory tfbs in AGAP2 promoter
     Search Chromatin IP Primers for AGAP2
     RT2 qPCR Primer Assay in human, mouse, rat AGAP2
     GNC Network for AGAP2
     SABiosciences Custom PCR Arrays for AGAP2
     Search Tocris compounds for AGAP2
     Browse Sino Biological Proteins and Antibodies
     Browse Sino Biological Cell Lysates
     Browse Sino Biological cDNA Clones
     4000+ Proteins
     Search Sino Biological for antibodies, proteins & pathways
     Protein Production Services
     Transfection Reagents
     Protein A/G/L resins
     Isotyping reagents
     Search www.enzolifesciences.com for proteins, assays, substrates, inhibitors & antibodies
     Novus Tissue Slides
     AGAP2 antibodies
     AGAP2 proteins
     Antibodies for AGAP2
     See all of Abcam's Antibodies, Kits and Proteins for AGAP2
     Custom Antibody / Protein Production Service
     Bulk Purchasing
     Advantages of Rabbit Monoclonal antibodies
     Abcam protocols and scientific support
     Browse ProSpec Recombinant Proteins




     Browse Proteins at Cloud-Clone Corp.
     Browse Antibodies at Cloud-Clone Corp.
     Browse ELISAs at Cloud-Clone Corp.
     Browse CLIAs at Cloud-Clone Corp.
     Search LifeMap BioReagents cell lines for AGAP2
     Gene Synthesis
     Protein Engineering
     Variant Library Synthesis
     Codon Optimization
     Protein Production and Purification
     Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for AGAP2
     SwitchGear 3'UTR luciferase reporter plasmids for AGAP2
     SwitchGear Promoter luciferase reporter plasmids for AGAP2
     ThermoFisher Antibodies for AGAP2
     Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat AGAP2
     inGenious Targeting Laboratory - Custom generated mouse model solutions for AGAP2
     inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for AGAP2
    Customized:
     lentivirus for stable overexpression of AGAP2
     lentivirus expression plasmids for stable overexpression of AGAP2
     adenovirus for overexpression of AGAP2
     LSBio Antibodies in human, mouse, rat for AGAP2
    Customized transgenic rodents for:
     Humanization
     Biomarker expression
     Off-target effect monitoring
     Translational medicine
     Tissue-specific gene expresssion
     Time-controlled gene expresssion
           
    GeneCards Homepage - Last full update: 23 Oct 2013 - Incrementals: 4 Nov 2013 , 7 Nov 2013 , 23 Jan 2014

    View Random Gene

    Category
    (GIFtS: 73)
    transforming growth factor, beta 1
    GIFtS Group
    The GeneCards human gene database gene index: 1 3 5 6 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z 


    Developed at the Crown Human Genome Center, Department of Molecular Genetics, the Weizmann Institute of Science

    Hot genes      Disease genes      AGAP2 gene at Home site.
    hostname: 356977-web1.xennexinc.com index build: 106 solr: 1.4