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Aliases for AGAP2 Gene

Aliases for AGAP2 Gene

  • ArfGAP With GTPase Domain, Ankyrin Repeat And PH Domain 2 2 3 5
  • Phosphatidylinositol 3-Kinase Enhancer 3 4
  • Centaurin, Gamma 1 2 3
  • Cnt-G1 3 4
  • CENTG1 3 4
  • GGAP2 3 4
  • PIKE 3 4
  • Arf GAP With GTP-Binding Protein-Like, ANK Repeat And PH Domains 2 3
  • Arf-GAP With GTPase, ANK Repeat And PH Domain-Containing Protein 2 3
  • GTP-Binding And GTPase Activating Protein 2 3
  • GTP-Binding And GTPase-Activating Protein 2 4
  • Phosphoinositide 3-Kinase Enhancer 3
  • Centaurin-Gamma-1 4
  • KIAA0167 4
  • AGAP-2 4

External Ids for AGAP2 Gene

Previous HGNC Symbols for AGAP2 Gene

  • CENTG1

Previous GeneCards Identifiers for AGAP2 Gene

  • GC12M056406
  • GC12M058118
  • GC12M055156

Summaries for AGAP2 Gene

Entrez Gene Summary for AGAP2 Gene

  • The protein encoded by this gene belongs to the centaurin gamma-like family. It mediates anti-apoptotic effects of nerve growth factor by activating nuclear phosphoinositide 3-kinase. It is overexpressed in cancer cells, and promotes cancer cell invasion. Alternatively spliced transcript variants encoding different isoforms have been described for this gene. [provided by RefSeq, Aug 2011]

GeneCards Summary for AGAP2 Gene

AGAP2 (ArfGAP With GTPase Domain, Ankyrin Repeat And PH Domain 2) is a Protein Coding gene. Among its related pathways are Developmental Biology and FoxO signaling pathway. GO annotations related to this gene include GTP binding and GTPase activator activity. An important paralog of this gene is AGAP1.

UniProtKB/Swiss-Prot for AGAP2 Gene

  • GTPase-activating protein (GAP) for ARF1 and ARF5, which also shows strong GTPase activity. Isoform 1 participates in the prevention of neuronal apoptosis by enhancing PI3 kinase activity. It aids the coupling of metabotropic glutamate receptor 1 (GRM1) to cytoplasmic PI3 kinase by interacting with Homer scaffolding proteins, and also seems to mediate anti-apoptotic effects of NGF by activating nuclear PI3 kinase. Isoform 2 does not stimulate PI3 kinase but may protect cells from apoptosis by stimulating Akt. It also regulates the adapter protein 1 (AP-1)-dependent trafficking of proteins in the endosomal system. It seems to be oncogenic. It is overexpressed in cancer cells, prevents apoptosis and promotes cancer cell invasion.

Gene Wiki entry for AGAP2 Gene

No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for AGAP2 Gene

Genomics for AGAP2 Gene

Regulatory Elements for AGAP2 Gene

Enhancers for AGAP2 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH12G057733 1.7 FANTOM5 Ensembl ENCODE 12.7 +3.7 3745 9.6 HDGF ARID4B ZNF143 ZNF548 SP3 REST ZNF662 SMARCA4 GLIS1 HMBOX1 TSFM NEMP1 ARHGAP9 ATP23 CTDSP2 AGAP2 DDIT3 KIF5A MARCH9 MBD6
GH12G057905 1.6 Ensembl ENCODE dbSUPER 9.1 -163.4 -163429 0.9 WRNIP1 ARID4B SIN3A ZNF2 YY1 ZNF143 DEK ZNF263 ZHX2 MXD4 ATP23 MIR26A2 RNU6-1083P CTDSP2 AVIL TSFM CYP27B1 METTL1 EEF1AKMT3 CDK4
GH12G057830 2 FANTOM5 Ensembl ENCODE dbSUPER 4.7 -97.3 -97279 17.0 MLX FEZF1 DMAP1 YY1 ZNF143 ZNF263 SP3 NFYC ZNF610 GLIS1 EEF1AKMT3 TSFM ATP23 METTL1 CTDSP2 TSPAN31 CDK4 AGAP2 LOC283387 PIR34053
GH12G057575 0.9 ENCODE 10.3 +165.5 165541 1.4 TBP FOXA2 ARID4B ZNF48 RARA SLC30A9 GATA4 CREM THAP11 SP5 DTX3 ARHGEF25 SLC26A10 ENSG00000224713 DCTN2 KIF5A B4GALNT1 DDIT3 MIR616 MBD6
GH12G057579 0.8 ENCODE 10.3 +162.3 162322 0.8 ELF3 TBP FOXA2 ATF1 ARID4B DMAP1 KAT2B CREM CEBPB KAT8 DCTN2 DTX3 ARHGEF25 SLC26A10 ENSG00000224713 KIF5A B4GALNT1 TSPAN31 AGAP2 MBD6
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around AGAP2 on UCSC Golden Path with GeneCards custom track

Promoters for AGAP2 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000052698 101 201 HDGF CTCF SUZ12 RAD21 CTBP1 POLR2A ZNF143 SMC3 IKZF2 ZNF687

Transcription factor binding sites by QIAGEN in the AGAP2 gene promoter:

Genomic Location for AGAP2 Gene

Chromosome:
12
Start:
57,723,761 bp from pter
End:
57,742,201 bp from pter
Size:
18,441 bases
Orientation:
Minus strand

Genomic View for AGAP2 Gene

Genes around AGAP2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
AGAP2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for AGAP2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for AGAP2 Gene

Proteins for AGAP2 Gene

  • Protein details for AGAP2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q99490-AGAP2_HUMAN
    Recommended name:
    Arf-GAP with GTPase, ANK repeat and PH domain-containing protein 2
    Protein Accession:
    Q99490
    Secondary Accessions:
    • A8K9F7
    • O00578
    • Q548E0
    • Q8IWU3

    Protein attributes for AGAP2 Gene

    Size:
    1192 amino acids
    Molecular mass:
    124674 Da
    Quaternary structure:
    • Isoform 1 interacts with EPB41L1, PLCG1, NF2, HOMER1 and HOMER2 (By similarity). Isoform 2 interacts with activated AKT1 in the presence of guanine nucleotides, and with the AP-1 complex.
    SequenceCaution:
    • Sequence=BAA11484.2; Type=Erroneous initiation; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for AGAP2 Gene

    Alternative splice isoforms for AGAP2 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for AGAP2 Gene

Post-translational modifications for AGAP2 Gene

  • Isoform PIKE-A is phosphorylated at Tyr-682 and Tyr-774 by FYN, preventing its apoptotic cleavage.
  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for AGAP2 Gene

No data available for DME Specific Peptides for AGAP2 Gene

Domains & Families for AGAP2 Gene

Suggested Antigen Peptide Sequences for AGAP2 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q99490

UniProtKB/Swiss-Prot:

AGAP2_HUMAN :
  • G domain binds GTP and has GTPase activity.
  • Belongs to the centaurin gamma-like family.
Domain:
  • G domain binds GTP and has GTPase activity.
  • Arf-GAP domain interacts with G domain and may regulate its GTPase activity.
  • Although both PH domains of isoforms 1 and 2 bind phospholipids, they differently regulate subcellular location. PH domain of isoform 1 directs the protein to the nucleus, but PH domain of isoform 2 directs it to the cytosol. PH domain of isoform 2 is required for binding to AP-1.
Family:
  • Belongs to the centaurin gamma-like family.
genes like me logo Genes that share domains with AGAP2: view

Function for AGAP2 Gene

Molecular function for AGAP2 Gene

UniProtKB/Swiss-Prot EnzymeRegulation:
GAP activity is stimulated by phosphatidylinositol 4,5-bisphosphate (PIP2) and, to a lesser extent, by phosphatidylinositol 3,4,5-trisphosphate (PIP3). Phosphatidic acid potentiates PIP2 stimulation.
UniProtKB/Swiss-Prot Function:
GTPase-activating protein (GAP) for ARF1 and ARF5, which also shows strong GTPase activity. Isoform 1 participates in the prevention of neuronal apoptosis by enhancing PI3 kinase activity. It aids the coupling of metabotropic glutamate receptor 1 (GRM1) to cytoplasmic PI3 kinase by interacting with Homer scaffolding proteins, and also seems to mediate anti-apoptotic effects of NGF by activating nuclear PI3 kinase. Isoform 2 does not stimulate PI3 kinase but may protect cells from apoptosis by stimulating Akt. It also regulates the adapter protein 1 (AP-1)-dependent trafficking of proteins in the endosomal system. It seems to be oncogenic. It is overexpressed in cancer cells, prevents apoptosis and promotes cancer cell invasion.

Gene Ontology (GO) - Molecular Function for AGAP2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003924 GTPase activity IEA --
GO:0005096 GTPase activator activity IEA --
GO:0005515 protein binding IPI 21720388
GO:0005525 GTP binding IEA --
GO:0019901 protein kinase binding IEA --
genes like me logo Genes that share ontologies with AGAP2: view
genes like me logo Genes that share phenotypes with AGAP2: view

Animal Models for AGAP2 Gene

MGI Knock Outs for AGAP2:

Animal Model Products

Inhibitory RNA Products

Clone Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , miRNA , Transcription Factor Targets and HOMER Transcription for AGAP2 Gene

Localization for AGAP2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for AGAP2 Gene

Isoform 1: Cytoplasm. Nucleus.
Isoform 2: Cytoplasm.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for AGAP2 gene
Compartment Confidence
extracellular 5
mitochondrion 5
nucleus 5
cytosol 1
endosome 1

Gene Ontology (GO) - Cellular Components for AGAP2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IDA,ISS 11136977
GO:0005730 nucleolus IDA --
GO:0005737 cytoplasm IEA --
GO:0005739 mitochondrion IDA --
GO:0016020 membrane IDA 19946888
genes like me logo Genes that share ontologies with AGAP2: view

Pathways & Interactions for AGAP2 Gene

genes like me logo Genes that share pathways with AGAP2: view

Pathways by source for AGAP2 Gene

2 KEGG pathways for AGAP2 Gene
1 GeneGo (Thomson Reuters) pathway for AGAP2 Gene

SIGNOR curated interactions for AGAP2 Gene

Is activated by:

Gene Ontology (GO) - Biological Process for AGAP2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006810 transport IEA --
GO:0007264 small GTPase mediated signal transduction IEA --
GO:0014068 positive regulation of phosphatidylinositol 3-kinase signaling IEA --
GO:0015031 protein transport IEA --
GO:0032147 activation of protein kinase activity IEA --
genes like me logo Genes that share ontologies with AGAP2: view

Drugs & Compounds for AGAP2 Gene

(1) Drugs for AGAP2 Gene - From: HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Guanosine triphosphate Experimental Pharma 0

(12) Additional Compounds for AGAP2 Gene - From: HMDB

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
PA(16:0/16:0)
  • 1,2-Di-O-palmitoyl-3-sn-glyceryl-O-phosphorate
  • 1,2-Di-O-palmitoyl-3-sn-glyceryl-O-phosphoric acid
  • 1,2-Dihexadecanoyl-rac-phosphatidic acid
  • 1,2-Dipalmitoyl-3-sn-phosphatidate
  • 1,2-Dipalmitoyl-3-sn-phosphatidic acid
7091-44-3
PA(16:0/18:1(11Z))
  • 1-Hexadecanoyl-2-(11Z-octadecenoyl)-sn-phosphatidic acid
  • 1-Palmitoyl-2-vaccenoyl-sn-glycero-3-phosphate
  • PA(16:0/18:1)
  • PA(16:0/18:1n7)
  • PA(16:0/18:1w7)
PA(16:0/18:1(9Z))
  • 1-Hexadecanoyl-2-(9Z-octadecenoyl)-sn-phosphatidic acid
  • 1-Palmitoyl-2-oleoyl-sn-glycero-3-phosphate
  • PA(16:0/18:1)
  • PA(16:0/18:1n9)
  • PA(16:0/18:1w9)
PA(16:0/18:2(9Z,12Z))
  • 1-Hexadecanoyl-2-(9Z,12Z-octadecadienoyl)-sn-phosphatidic acid
  • 1-Palmitoyl-2-linoleoyl-sn-glycero-3-phosphate
  • PA(16:0/18:2)
  • PA(16:0/18:2n6)
  • PA(16:0/18:2w6)
PA(16:0e/18:0)
  • 2-Octadecanoyl-1-hexadecyl-sn-glycero-3-phosphate
  • PA(O-16:0/18:0)
genes like me logo Genes that share compounds with AGAP2: view

Transcripts for AGAP2 Gene

Unigene Clusters for AGAP2 Gene

ArfGAP with GTPase domain, ankyrin repeat and PH domain 2:
Representative Sequences:

Inhibitory RNA Products

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for AGAP2 Gene

ExUns: 1 ^ 2a · 2b ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11 ^ 12 ^ 13 ^ 14 ^ 15 ^ 16 ^ 17 ^ 18 ^ 19 ^ 20a · 20b · 20c
SP1:
SP2:
SP3: - - -

Relevant External Links for AGAP2 Gene

GeneLoc Exon Structure for
AGAP2
ECgene alternative splicing isoforms for
AGAP2

Expression for AGAP2 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for AGAP2 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for AGAP2 Gene

This gene is overexpressed in Brain - Cortex (x5.7), Brain - Cerebellum (x5.4), Brain - Nucleus accumbens (basal ganglia) (x4.9), Brain - Anterior cingulate cortex (BA24) (x4.7), Brain - Hippocampus (x4.6), Brain - Cerebellar Hemisphere (x4.6), Brain - Amygdala (x4.3), and Brain - Frontal Cortex (BA9) (x4.1).

Protein differential expression in normal tissues from HIPED for AGAP2 Gene

This gene is overexpressed in Peripheral blood mononuclear cells (12.8), Stomach (11.1), and Brain (8.8).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for AGAP2 Gene



NURSA nuclear receptor signaling pathways regulating expression of AGAP2 Gene:

AGAP2

SOURCE GeneReport for Unigene cluster for AGAP2 Gene:

Hs.302435

mRNA Expression by UniProt/SwissProt for AGAP2 Gene:

Q99490-AGAP2_HUMAN
Tissue specificity: Isoform 1 is brain-specific. Isoform 2 is ubiquitously expressed, with highest levels in brain and heart.

Evidence on tissue expression from TISSUES for AGAP2 Gene

  • Blood(4.1)
  • Bone marrow(4.1)
  • Heart(4.1)
  • Nervous system(2.5)
genes like me logo Genes that share expression patterns with AGAP2: view

Primer Products

No data available for Protein tissue co-expression partners and Phenotype-based relationships between genes and organs from Gene ORGANizer for AGAP2 Gene

Orthologs for AGAP2 Gene

This gene was present in the common ancestor of animals.

Orthologs for AGAP2 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia AGAP2 34 35
  • 98.03 (n)
cow
(Bos Taurus)
Mammalia AGAP2 34 35
  • 92.59 (n)
dog
(Canis familiaris)
Mammalia AGAP2 35
  • 90 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Agap2 34 16 35
  • 88.81 (n)
rat
(Rattus norvegicus)
Mammalia Agap2 34
  • 88.67 (n)
platypus
(Ornithorhynchus anatinus)
Mammalia AGAP2 35
  • 81 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia AGAP2 35
  • 14 (a)
OneToOne
chicken
(Gallus gallus)
Aves -- 35
  • 15 (a)
ManyToMany
lizard
(Anolis carolinensis)
Reptilia AGAP2 35
  • 58 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia LOC100496997 34
  • 61.38 (n)
zebrafish
(Danio rerio)
Actinopterygii agap2 34 35
  • 60.14 (n)
fruit fly
(Drosophila melanogaster)
Insecta Asap1 35
  • 14 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea CSA.5006 35
  • 15 (a)
OneToMany
Species where no ortholog for AGAP2 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for AGAP2 Gene

ENSEMBL:
Gene Tree for AGAP2 (if available)
TreeFam:
Gene Tree for AGAP2 (if available)

Paralogs for AGAP2 Gene

genes like me logo Genes that share paralogs with AGAP2: view

Variants for AGAP2 Gene

Sequence variations from dbSNP and Humsavar for AGAP2 Gene

SNP ID Clin Chr 12 pos Sequence Context AA Info Type
VAR_026438 A glioblastoma cell line
VAR_026439 A sarcoma cell line
VAR_026441 A glioblastoma cell line
VAR_026442 A glioblastoma cell line
VAR_026443 A glioblastoma cell line

Structural Variations from Database of Genomic Variants (DGV) for AGAP2 Gene

Variant ID Type Subtype PubMed ID
nsv1071036 CNV deletion 25765185
nsv1143566 CNV deletion 24896259
nsv470296 CNV loss 18288195
nsv470297 CNV gain 18288195
nsv510601 CNV deletion 20534489
nsv559045 CNV loss 21841781
nsv826383 CNV gain 20364138
nsv826384 CNV gain 20364138
nsv826385 CNV gain 20364138
nsv826386 CNV gain 20364138

Variation tolerance for AGAP2 Gene

Residual Variation Intolerance Score: 16.2% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 3.50; 55.29% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for AGAP2 Gene

Human Gene Mutation Database (HGMD)
AGAP2
SNPedia medical, phenotypic, and genealogical associations of SNPs for
AGAP2

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for AGAP2 Gene

Disorders for AGAP2 Gene

Relevant External Links for AGAP2

Genetic Association Database (GAD)
AGAP2
Human Genome Epidemiology (HuGE) Navigator
AGAP2
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
AGAP2

No disorders were found for AGAP2 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for AGAP2 Gene

Publications for AGAP2 Gene

  1. The centaurin gamma-1 GTPase-like domain functions as an NTPase. (PMID: 17037982) Soundararajan M. … Doyle D.A. (Biochem. J. 2007) 3 4 22 64
  2. The Arf GAPs AGAP1 and AGAP2 distinguish between the adaptor protein complexes AP-1 and AP-3. (PMID: 16079295) Nie Z. … Randazzo P.A. (J. Cell Sci. 2005) 3 4 22 64
  3. Genetic alteration and expression of the phosphoinositol-3-kinase/Akt pathway genes PIK3CA and PIKE in human glioblastomas. (PMID: 16150119) Knobbe C.B. … Reifenberger G. (Neuropathol. Appl. Neurobiol. 2005) 3 4 22 64
  4. PIKE (phosphatidylinositol 3-kinase enhancer)-A GTPase stimulates Akt activity and mediates cellular invasion. (PMID: 14761976) Ahn J.-Y. … Ye K. (J. Biol. Chem. 2004) 3 4 22 64
  5. Arf GTPase-activating protein AGAP2 regulates focal adhesion kinase activity and focal adhesion remodeling. (PMID: 19318351) Zhu Y. … Nie Z. (J. Biol. Chem. 2009) 3 22 64

Products for AGAP2 Gene

Sources for AGAP2 Gene

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