Free for academic non-profit institutions. Other users need a Commercial license

Aliases for AGAP2 Gene

Aliases for AGAP2 Gene

  • ArfGAP With GTPase Domain, Ankyrin Repeat And PH Domain 2 2 3 5
  • Phosphatidylinositol 3-Kinase Enhancer 3 4
  • Centaurin, Gamma 1 2 3
  • Cnt-G1 3 4
  • CENTG1 3 4
  • GGAP2 3 4
  • PIKE 3 4
  • Arf GAP With GTP-Binding Protein-Like, ANK Repeat And PH Domains 2 3
  • GTP-Binding And GTPase Activating Protein 2 3
  • GTP-Binding And GTPase-Activating Protein 2 4
  • Phosphatidylinositol-3-Kinase Enhancer 3
  • Phosphoinositide 3-Kinase Enhancer 3
  • Centaurin-Gamma-1 4
  • KIAA0167 4
  • AGAP-2 4

External Ids for AGAP2 Gene

Previous HGNC Symbols for AGAP2 Gene

  • CENTG1

Previous GeneCards Identifiers for AGAP2 Gene

  • GC12M056406
  • GC12M058118
  • GC12M055156

Summaries for AGAP2 Gene

Entrez Gene Summary for AGAP2 Gene

  • The protein encoded by this gene belongs to the centaurin gamma-like family. It mediates anti-apoptotic effects of nerve growth factor by activating nuclear phosphoinositide 3-kinase. It is overexpressed in cancer cells, and promotes cancer cell invasion. Alternatively spliced transcript variants encoding different isoforms have been described for this gene. [provided by RefSeq, Aug 2011]

GeneCards Summary for AGAP2 Gene

AGAP2 (ArfGAP With GTPase Domain, Ankyrin Repeat And PH Domain 2) is a Protein Coding gene. Among its related pathways are Developmental Biology and Netrin-1 signaling. GO annotations related to this gene include GTP binding and GTPase activator activity. An important paralog of this gene is ASAP3.

UniProtKB/Swiss-Prot for AGAP2 Gene

  • GTPase-activating protein (GAP) for ARF1 and ARF5, which also shows strong GTPase activity. Isoform 1 participates in the prevention of neuronal apoptosis by enhancing PI3 kinase activity. It aids the coupling of metabotropic glutamate receptor 1 (GRM1) to cytoplasmic PI3 kinase by interacting with Homer scaffolding proteins, and also seems to mediate anti-apoptotic effects of NGF by activating nuclear PI3 kinase. Isoform 2 does not stimulate PI3 kinase but may protect cells from apoptosis by stimulating Akt. It also regulates the adapter protein 1 (AP-1)-dependent trafficking of proteins in the endosomal system. It seems to be oncogenic. It is overexpressed in cancer cells, prevents apoptosis and promotes cancer cell invasion.

Gene Wiki entry for AGAP2 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for AGAP2 Gene

Genomics for AGAP2 Gene

Regulatory Elements for AGAP2 Gene

Promoters for AGAP2 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around AGAP2 on UCSC Golden Path with GeneCards custom track

Transcription factor binding sites by QIAGEN in the AGAP2 gene promoter:

Genomic Location for AGAP2 Gene

Chromosome:
12
Start:
57,723,761 bp from pter
End:
57,742,201 bp from pter
Size:
18,441 bases
Orientation:
Minus strand

Genomic View for AGAP2 Gene

Genes around AGAP2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
AGAP2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for AGAP2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for AGAP2 Gene

Proteins for AGAP2 Gene

  • Protein details for AGAP2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q99490-AGAP2_HUMAN
    Recommended name:
    Arf-GAP with GTPase, ANK repeat and PH domain-containing protein 2
    Protein Accession:
    Q99490
    Secondary Accessions:
    • A8K9F7
    • O00578
    • Q548E0
    • Q8IWU3

    Protein attributes for AGAP2 Gene

    Size:
    1192 amino acids
    Molecular mass:
    124674 Da
    Quaternary structure:
    • Isoform 1 interacts with EPB41L1, PLCG1, NF2, HOMER1 and HOMER2 (By similarity). Isoform 2 interacts with activated AKT1 in the presence of guanine nucleotides, and with the AP-1 complex.
    SequenceCaution:
    • Sequence=BAA11484.2; Type=Erroneous initiation; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for AGAP2 Gene

    Alternative splice isoforms for AGAP2 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for AGAP2 Gene

Proteomics data for AGAP2 Gene at MOPED

Post-translational modifications for AGAP2 Gene

  • Isoform PIKE-A is phosphorylated at Tyr-682 and Tyr-774 by FYN, preventing its apoptotic cleavage.
  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for AGAP2 Gene

Antibody Products

No data available for DME Specific Peptides for AGAP2 Gene

Domains & Families for AGAP2 Gene

Suggested Antigen Peptide Sequences for AGAP2 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q99490

UniProtKB/Swiss-Prot:

AGAP2_HUMAN :
  • G domain binds GTP and has GTPase activity.
  • Belongs to the centaurin gamma-like family.
  • Contains 2 ANK repeats.
Domain:
  • G domain binds GTP and has GTPase activity.
  • Arf-GAP domain interacts with G domain and may regulate its GTPase activity.
  • Although both PH domains of isoforms 1 and 2 bind phospholipids, they differently regulate subcellular location. PH domain of isoform 1 directs the protein to the nucleus, but PH domain of isoform 2 directs it to the cytosol. PH domain of isoform 2 is required for binding to AP-1.
  • Contains 1 Arf-GAP domain.
  • Contains 1 PH domain.
Family:
  • Belongs to the centaurin gamma-like family.
Similarity:
  • Contains 2 ANK repeats.
genes like me logo Genes that share domains with AGAP2: view

Function for AGAP2 Gene

Molecular function for AGAP2 Gene

UniProtKB/Swiss-Prot EnzymeRegulation:
GAP activity is stimulated by phosphatidylinositol 4,5-bisphosphate (PIP2) and, to a lesser extent, by phosphatidylinositol 3,4,5-trisphosphate (PIP3). Phosphatidic acid potentiates PIP2 stimulation.
UniProtKB/Swiss-Prot Function:
GTPase-activating protein (GAP) for ARF1 and ARF5, which also shows strong GTPase activity. Isoform 1 participates in the prevention of neuronal apoptosis by enhancing PI3 kinase activity. It aids the coupling of metabotropic glutamate receptor 1 (GRM1) to cytoplasmic PI3 kinase by interacting with Homer scaffolding proteins, and also seems to mediate anti-apoptotic effects of NGF by activating nuclear PI3 kinase. Isoform 2 does not stimulate PI3 kinase but may protect cells from apoptosis by stimulating Akt. It also regulates the adapter protein 1 (AP-1)-dependent trafficking of proteins in the endosomal system. It seems to be oncogenic. It is overexpressed in cancer cells, prevents apoptosis and promotes cancer cell invasion.

Gene Ontology (GO) - Molecular Function for AGAP2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0019901 protein kinase binding IEA --
genes like me logo Genes that share ontologies with AGAP2: view
genes like me logo Genes that share phenotypes with AGAP2: view

Animal Models for AGAP2 Gene

MGI Knock Outs for AGAP2:

Animal Model Products

CRISPR Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , miRNA , Transcription Factor Targets and HOMER Transcription for AGAP2 Gene

Localization for AGAP2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for AGAP2 Gene

Isoform 1: Cytoplasm. Nucleus.
Isoform 2: Cytoplasm.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for AGAP2 Gene COMPARTMENTS Subcellular localization image for AGAP2 gene
Compartment Confidence
extracellular 5
mitochondrion 5
nucleus 5
cytosol 1
endosome 1
golgi apparatus 1

Gene Ontology (GO) - Cellular Components for AGAP2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0016020 membrane IEA,IDA 19946888
genes like me logo Genes that share ontologies with AGAP2: view

Pathways & Interactions for AGAP2 Gene

genes like me logo Genes that share pathways with AGAP2: view

Pathways by source for AGAP2 Gene

2 KEGG pathways for AGAP2 Gene
1 GeneGo (Thomson Reuters) pathway for AGAP2 Gene

SIGNOR curated interactions for AGAP2 Gene

Is activated by:

Gene Ontology (GO) - Biological Process for AGAP2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007165 signal transduction IEA --
GO:0007411 axon guidance TAS --
GO:0032147 activation of protein kinase activity IEA --
GO:0033601 positive regulation of mammary gland epithelial cell proliferation IEA --
GO:0043524 negative regulation of neuron apoptotic process IEA,IGI 18374643
genes like me logo Genes that share ontologies with AGAP2: view

Drugs & Compounds for AGAP2 Gene

(2) Drugs for AGAP2 Gene - From: PharmGKB and HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Somatropin recombinant Approved, Investigational Pharma 0
Guanosine triphosphate Experimental Pharma 0

(12) Additional Compounds for AGAP2 Gene - From: HMDB

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
PA(16:0/16:0)
  • 1,2-Di-O-palmitoyl-3-sn-glyceryl-O-phosphorate
  • 1,2-Di-O-palmitoyl-3-sn-glyceryl-O-phosphoric acid
  • 1,2-Dihexadecanoyl-rac-phosphatidic acid
  • 1,2-Dipalmitoyl-3-sn-phosphatidate
  • 1,2-Dipalmitoyl-3-sn-phosphatidic acid
7091-44-3
PA(16:0/18:1(11Z))
  • 1-Hexadecanoyl-2-(11Z-octadecenoyl)-sn-phosphatidic acid
  • 1-Palmitoyl-2-vaccenoyl-sn-glycero-3-phosphate
  • PA(16:0/18:1)
  • PA(16:0/18:1n7)
  • PA(16:0/18:1w7)
PA(16:0/18:1(9Z))
  • 1-Hexadecanoyl-2-(9Z-octadecenoyl)-sn-phosphatidic acid
  • 1-Palmitoyl-2-oleoyl-sn-glycero-3-phosphate
  • PA(16:0/18:1)
  • PA(16:0/18:1n9)
  • PA(16:0/18:1w9)
PA(16:0/18:2(9Z,12Z))
  • 1-Hexadecanoyl-2-(9Z,12Z-octadecadienoyl)-sn-phosphatidic acid
  • 1-Palmitoyl-2-linoleoyl-sn-glycero-3-phosphate
  • PA(16:0/18:2)
  • PA(16:0/18:2n6)
  • PA(16:0/18:2w6)
PA(16:0e/18:0)
  • 2-Octadecanoyl-1-hexadecyl-sn-glycero-3-phosphate
  • PA(O-16:0/18:0)
genes like me logo Genes that share compounds with AGAP2: view

Transcripts for AGAP2 Gene

Unigene Clusters for AGAP2 Gene

ArfGAP with GTPase domain, ankyrin repeat and PH domain 2:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for AGAP2 Gene

ExUns: 1 ^ 2a · 2b ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11 ^ 12 ^ 13 ^ 14 ^ 15 ^ 16 ^ 17 ^ 18 ^ 19 ^ 20a · 20b · 20c
SP1:
SP2:
SP3: - - -

Relevant External Links for AGAP2 Gene

GeneLoc Exon Structure for
AGAP2
ECgene alternative splicing isoforms for
AGAP2

Expression for AGAP2 Gene

mRNA expression in normal human tissues for AGAP2 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for AGAP2 Gene

This gene is overexpressed in Brain - Cortex (x5.7), Brain - Cerebellum (x5.4), Brain - Nucleus accumbens (basal ganglia) (x4.9), Brain - Anterior cingulate cortex (BA24) (x4.7), Brain - Hippocampus (x4.6), Brain - Cerebellar Hemisphere (x4.6), Brain - Amygdala (x4.3), and Brain - Frontal Cortex (BA9) (x4.1).

Protein differential expression in normal tissues from HIPED for AGAP2 Gene

This gene is overexpressed in Peripheral blood mononuclear cells (12.8), Stomach (11.1), and Brain (8.8).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for AGAP2 Gene



SOURCE GeneReport for Unigene cluster for AGAP2 Gene Hs.302435

mRNA Expression by UniProt/SwissProt for AGAP2 Gene

Q99490-AGAP2_HUMAN
Tissue specificity: Isoform 1 is brain-specific. Isoform 2 is ubiquitously expressed, with highest levels in brain and heart.
genes like me logo Genes that share expression patterns with AGAP2: view

Primer Products

In Situ Assay Products

No data available for Protein tissue co-expression partners for AGAP2 Gene

Orthologs for AGAP2 Gene

This gene was present in the common ancestor of animals.

Orthologs for AGAP2 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia AGAP2 35
  • 92.59 (n)
  • 95.79 (a)
AGAP2 36
  • 96 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Agap2 35
  • 88.81 (n)
  • 93.76 (a)
Agap2 16
Agap2 36
  • 95 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia AGAP2 35
  • 98.03 (n)
  • 97.74 (a)
AGAP2 36
  • 100 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Agap2 35
  • 88.67 (n)
  • 93.76 (a)
dog
(Canis familiaris)
Mammalia AGAP2 36
  • 90 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia AGAP2 36
  • 14 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia AGAP2 36
  • 81 (a)
OneToOne
chicken
(Gallus gallus)
Aves -- 36
  • 15 (a)
ManyToMany
lizard
(Anolis carolinensis)
Reptilia AGAP2 36
  • 58 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia LOC100496997 35
  • 61.38 (n)
  • 64.09 (a)
zebrafish
(Danio rerio)
Actinopterygii agap2 35
  • 60.14 (n)
  • 59.25 (a)
agap2 36
  • 53 (a)
OneToOne
fruit fly
(Drosophila melanogaster)
Insecta Asap1 36
  • 14 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea CSA.5006 36
  • 15 (a)
OneToMany
Species with no ortholog for AGAP2:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for AGAP2 Gene

ENSEMBL:
Gene Tree for AGAP2 (if available)
TreeFam:
Gene Tree for AGAP2 (if available)

Paralogs for AGAP2 Gene

genes like me logo Genes that share paralogs with AGAP2: view

Variants for AGAP2 Gene

Sequence variations from dbSNP and Humsavar for AGAP2 Gene

SNP ID Clin Chr 12 pos Sequence Context AA Info Type
rs2301553 - 57,734,056(+) CAGGC(C/T)TCCTC nc-transcript-variant, reference, missense
VAR_026438 A glioblastoma cell line
VAR_026439 A sarcoma cell line
VAR_026440 -
VAR_026441 A glioblastoma cell line

Structural Variations from Database of Genomic Variants (DGV) for AGAP2 Gene

Variant ID Type Subtype PubMed ID
nsv899121 CNV Loss 21882294
nsv470296 CNV Loss 18288195
nsv826383 CNV Gain 20364138
nsv899122 CNV Loss 21882294
nsv899123 CNV Loss 21882294
nsv826384 CNV Gain 20364138
nsv826385 CNV Gain 20364138
nsv510601 CNV Loss 20534489
nsv470297 CNV Gain 18288195
nsv826386 CNV Gain 20364138

Variation tolerance for AGAP2 Gene

Residual Variation Intolerance Score: 16.2% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 3.50; 55.29% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for AGAP2 Gene

HapMap Linkage Disequilibrium report
AGAP2

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for AGAP2 Gene

Disorders for AGAP2 Gene

Relevant External Links for AGAP2

Genetic Association Database (GAD)
AGAP2
Human Genome Epidemiology (HuGE) Navigator
AGAP2
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
AGAP2

No disorders were found for AGAP2 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for AGAP2 Gene

Publications for AGAP2 Gene

  1. The Arf GAPs AGAP1 and AGAP2 distinguish between the adaptor protein complexes AP-1 and AP-3. (PMID: 16079295) Nie Z. … Randazzo P.A. (J. Cell Sci. 2005) 3 4 23 67
  2. Arf GTPase-activating protein AGAP2 regulates focal adhesion kinase activity and focal adhesion remodeling. (PMID: 19318351) Zhu Y. … Nie Z. (J. Biol. Chem. 2009) 3 23
  3. The centaurin gamma-1 GTPase-like domain functions as an NTPase. (PMID: 17037982) Soundararajan M. … Doyle D.A. (Biochem. J. 2007) 3 23
  4. PIKE GTPase signaling and function. (PMID: 15951849) Ahn J.Y. … Ye K. (Int. J. Biol. Sci. 2005) 3 23
  5. Genetic alteration and expression of the phosphoinositol-3-kinase/Akt pathway genes PIK3CA and PIKE in human glioblastomas. (PMID: 16150119) Knobbe C.B. … Reifenberger G. (Neuropathol. Appl. Neurobiol. 2005) 3 23

Products for AGAP2 Gene

Sources for AGAP2 Gene

Back to Top

Content