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AGAP2 Gene

protein-coding   GIFtS: 63
GCID: GC12M058118

ArfGAP With GTPase Domain, Ankyrin Repeat And PH Domain...

(Previous names: centaurin, gamma 1)
(Previous symbol: CENTG1)
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(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
ArfGAP With GTPase Domain, Ankyrin Repeat And PH Domain 21 2     GTP-Binding And GTPase Activating Protein 22
CENTG11 2 3     Phosphatidylinositol-3-Kinase Enhancer2
PIKE2 3 5     Phosphoinositide 3-Kinase Enhancer2
Centaurin, Gamma 11 2     AGAP-23
Phosphatidylinositol 3-Kinase Enhancer2 3     Centaurin-gamma-13
GGAP22 3     Cnt-g13
Arf GAP With GTP-Binding Protein-Like, ANK Repeat And PH Domains 22     KIAA01673
Arf-GAP With GTPase, ANK Repeat And PH Domain-Containing Protein 22     GTP-Binding And GTPase-Activating Protein 23
cnt-g12     

External Ids:    HGNC: 169211   Entrez Gene: 1169862   Ensembl: ENSG000001354397   OMIM: 6054765   UniProtKB: Q994903   

Export aliases for AGAP2 gene to outside databases

Previous GC identifers: GC12M056406 GC12M055156


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for AGAP2 Gene:
The protein encoded by this gene belongs to the centaurin gamma-like family. It mediates anti-apoptotic effects of
nerve growth factor by activating nuclear phosphoinositide 3-kinase. It is overexpressed in cancer cells, and
promotes cancer cell invasion. Alternatively spliced transcript variants encoding different isoforms have been
described for this gene. (provided by RefSeq, Aug 2011)

GeneCards Summary for AGAP2 Gene:
AGAP2 (ArfGAP with GTPase domain, ankyrin repeat and PH domain 2) is a protein-coding gene. Diseases associated with AGAP2 include anisakiasis, and diphyllobothriasis. GO annotations related to this gene include ARF GTPase activator activity and GTP binding. An important paralog of this gene is AGAP5.

UniProtKB/Swiss-Prot: AGAP2_HUMAN, Q99490
Function: GTPase-activating protein (GAP) for ARF1 and ARF5, which also shows strong GTPase activity. Isoform 1
participates in the prevention of neuronal apoptosis by enhancing PI3 kinase activity. It aids the coupling of
metabotropic glutamate receptor 1 (GRM1) to cytoplasmic PI3 kinase by interacting with Homer scaffolding
proteins, and also seems to mediate anti-apoptotic effects of NGF by activating nuclear PI3 kinase. Isoform 2
does not stimulate PI3 kinase but may protect cells from apoptosis by stimulating Akt. It also regulates the
adapter protein 1 (AP-1)-dependent trafficking of proteins in the endosomal system. It seems to be oncogenic. It
is overexpressed in cancer cells, prevents apoptosis and promotes cancer cell invasion

Gene Wiki entry for AGAP2 (CENTG1) Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence:
NC_000012.12  NT_029419.13  NC_018923.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the AGAP2 gene promoter:
         AP-1   ATF-2   c-Jun   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmids (see all 2): AGAP2 promoter sequence
   Search Chromatin IP Primers for AGAP2

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat AGAP2


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 12q14.1   Ensembl cytogenetic band:  12q14.1   HGNC cytogenetic band: 12q13.2

AGAP2 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
AGAP2 gene location

GeneLoc information about chromosome 12         GeneLoc Exon Structure

GeneLoc location for GC12M058118:  view genomic region     (about GC identifiers)

Start:
58,118,980 bp from pter      End:
58,135,940 bp from pter
Size:
16,961 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
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UniProtKB/Swiss-Prot: AGAP2_HUMAN, Q99490 (See protein sequence)
Recommended Name: Arf-GAP with GTPase, ANK repeat and PH domain-containing protein 2  
Size: 1192 amino acids; 124674 Da
Subunit: Isoform 1 interacts with EPB41L1, PLCG1, NF2, HOMER1 and HOMER2 (By similarity). Isoform 2 interacts with
activated AKT1 in the presence of guanine nucleotides, and with the AP-1 complex
Sequence caution: Sequence=BAA11484.2; Type=Erroneous initiation;
3 PDB 3D structures from and Proteopedia for AGAP2:
2BMJ (3D)        2IWR (3D)        2RLO (3D)    
Secondary accessions: A8K9F7 O00578 Q548E0 Q8IWU3
Alternative splicing: 2 isoforms:  Q99490-1   Q99490-2   (Contains a phosphotyrosine at position 682. Contains a phosphotyrosine at position 774)

Explore the universe of human proteins at neXtProt for AGAP2: NX_Q99490

Explore proteomics data for AGAP2 at MOPED

Post-translational modifications: 

  • Isoform PIKE-A is phosphorylated at Tyr-682 and Tyr-774 by FYN, preventing its apoptotic cleavage1
  • Modification sites at neXtProt
  • Modification sites at PhosphoSitePlus

  • See AGAP2 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (2 alternative transcripts): 
    NP_001116244.1  NP_055585.1  

    ENSEMBL proteins: 
     ENSP00000328160   ENSP00000257897   ENSP00000449241   ENSP00000446683  
    Reactome Protein details: Q99490

    AGAP2 Human Recombinant Protein Products:

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    Browse Proteins at Cloud-Clone Corp.

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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    PLEKH: Pleckstrin homology (PH) domain containing
    ANKRD: Ankyrin repeat domain containing
    ArfGAP: ADP-ribosylation factor GTPase activating proteins

    Selected InterPro protein domains (see all 7):
     IPR013684 MIRO-like
     IPR001849 Pleckstrin_homology
     IPR001164 ArfGAP
     IPR011993 PH_like_dom
     IPR002110 Ankyrin_rpt

    Graphical View of Domain Structure for InterPro Entry Q99490

    ProtoNet protein and cluster: Q99490

    4 Blocks protein domains:
    IPB001164 HIV Rev interacting protein signature
    IPB001849 Pleckstrin-like
    IPB002110 Ankyrin repeat signature
    IPB013684 Miro-like


    UniProtKB/Swiss-Prot: AGAP2_HUMAN, Q99490
    Domain: G domain binds GTP and has GTPase activity
    Domain: Arf-GAP domain interacts with G domain and may regulate its GTPase activity
    Domain: Although both PH domains of isoforms 1 and 2 bind phospholipids, they differently regulate subcellular
    location. PH domain of isoform 1 directs the protein to the nucleus, but PH domain of isoform 2 directs it to the
    cytosol. PH domain of isoform 2 is required for binding to AP-1
    Similarity: Belongs to the centaurin gamma-like family
    Similarity: Contains 2 ANK repeats
    Similarity: Contains 1 Arf-GAP domain
    Similarity: Contains 1 PH domain


    AGAP2 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: AGAP2_HUMAN, Q99490
    Function: GTPase-activating protein (GAP) for ARF1 and ARF5, which also shows strong GTPase activity. Isoform 1
    participates in the prevention of neuronal apoptosis by enhancing PI3 kinase activity. It aids the coupling of
    metabotropic glutamate receptor 1 (GRM1) to cytoplasmic PI3 kinase by interacting with Homer scaffolding
    proteins, and also seems to mediate anti-apoptotic effects of NGF by activating nuclear PI3 kinase. Isoform 2
    does not stimulate PI3 kinase but may protect cells from apoptosis by stimulating Akt. It also regulates the
    adapter protein 1 (AP-1)-dependent trafficking of proteins in the endosomal system. It seems to be oncogenic. It
    is overexpressed in cancer cells, prevents apoptosis and promotes cancer cell invasion
    Enzyme regulation: GAP activity is stimulated by phosphatidylinositol 4,5-bisphosphate (PIP2) and, to a lesser
    extent, by phosphatidylinositol 3,4,5-trisphosphate (PIP3). Phosphatidic acid potentiates PIP2 stimulation

         Gene Ontology (GO): Selected molecular function terms (see all 6):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005515protein binding IPI--
    GO:0005525GTP binding IEA--
    GO:0008060ARF GTPase activator activity IEA--
    GO:0008270zinc ion binding IEA--
    GO:0019901protein kinase binding ----
         
    AGAP2 for ontologies           About GeneDecksing


    Phenotypes:
         5 GenomeRNAi human phenotypes for AGAP2:
     Altered focal adhesion (FA) or  Decreased Tat-dependent transc  Decreased Wnt reporter activit  Decreased p24 protein expressi 
     Increased gamma-H2AX phosphory 

         5 MGI mutant phenotypes (inferred from 2 alleles(MGI details for Agap2):
     endocrine/exocrine gland  growth/size/body  homeostasis/metabolism  integument  liver/biliary system 

    AGAP2 for phenotypes           About GeneDecksing

    Animal Models:
         MGI mouse knock-out Agap2tm1.1Kye for AGAP2

       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for AGAP2
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       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for AGAP2
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for AGAP2

    miRNA
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    Selected qRT-PCR Assays for microRNAs that regulate AGAP2 (see all 63):
    hsa-miR-1321 hsa-miR-3194-5p hsa-miR-136 hsa-miR-520e hsa-miR-302d hsa-miR-1914* hsa-miR-513a-5p hsa-miR-624
    SwitchGear 3'UTR luciferase reporter plasmidAGAP2 3' UTR sequence
    Inhib. RNA
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    Predesigned siRNA for gene silencing in human, mouse, rat AGAP2

    Gene Editing
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    GenScript: all cDNA clones in your preferred vector (see all 2): AGAP2 (NM_014770)
    Browse Sino Biological Human cDNA Clones
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for AGAP2


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    AGAP2_HUMAN, Q99490: Isoform 1: Cytoplasm. Nucleus
    AGAP2_HUMAN, Q99490: Isoform 2: Cytoplasm
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    nucleus5
    mitochondrion4
    cytoskeleton1
    cytosol1
    endosome1
    extracellular1
    plasma membrane1

    Gene Ontology (GO): 5 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005622intracellular ----
    GO:0005634nucleus ISS11136977
    GO:0005730nucleolus IDA--
    GO:0005739mitochondrion IDA--
    GO:0016020membrane ----

    AGAP2 for ontologies           About GeneDecksing


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for AGAP2 About   (see all 7)                                                                                              See pathways by source

    SuperPathContained pathways About
    1L1CAM interactions
    Axon guidance0.63
    Developmental Biology0.63
    2Prolactin Signaling Pathway
    Prolactin Signaling Pathway0.39
    3Development HGF signaling pathway
    Apoptosis and survival NGF signaling pathway0.36
    4Trk receptor signaling mediated by PI3K and PLC-gamma
    Trk receptor signaling mediated by PI3K and PLC-gamma
    5Netrin-1 signaling
    Netrin-1 signaling

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways


    1 GeneGo (Thomson Reuters) Pathway for AGAP2
        Apoptosis and survival NGF signaling pathway

    2 BioSystems Pathways for AGAP2
        Prolactin Signaling Pathway
    Trk receptor signaling mediated by PI3K and PLC-gamma

    1 Reactome Pathway for AGAP2
        Netrin-1 signaling


    2 Kegg Pathways  (Kegg details for AGAP2):
        FoxO signaling pathway
    Endocytosis


    AGAP2 for pathways           About GeneDecksing

        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for AGAP2
    Interactions:

        GeneGlobe Interaction Network for AGAP2

    STRING Interaction Network Preview (showing 5 interactants - click image to see 22)

    Selected Interacting proteins for AGAP2 (Q994901, 2, 3 ENSP000003281604) via UniProtKB, MINT, STRING, and/or I2D (see all 28)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    STAT5AP422291, 2, 3, ENSP000003412084EBI-7737644,EBI-749537 MINT-7760983 MINT-7760966 MINT-7761049 I2D: score=1 STRING: ENSP00000341208
    INSRP062131, 2, 3, ENSP000003038304EBI-2361824,EBI-475899 MINT-8204673 MINT-8204689 I2D: score=2 STRING: ENSP00000303830
    HOMER1Q86YM73, ENSP000003343824I2D: score=4 STRING: ENSP00000334382
    EPB41L1Q9H4G03, ENSP000003371684I2D: score=3 STRING: ENSP00000337168
    HOMER2Q9NSB83, ENSP000003056324I2D: score=3 STRING: ENSP00000305632
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 15):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006184GTP catabolic process ----
    GO:0007165signal transduction ----
    GO:0007264small GTPase mediated signal transduction IEA--
    GO:0007411axon guidance TAS--
    GO:0015031protein transport IEA--

    AGAP2 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for AGAP2

    Selected HMDB Compounds for AGAP2 (see all 13)    About this table
    CompoundSynonyms CAS #PubMed Ids
    Guanosine triphosphate5'-GTP (see all 10)86-01-1--
    PA(16:0/16:0)Dipalmitoylphosphatidic acid (see all 25)7091-44-3--
    PA(16:0/18:1(11Z))PA(16:0/18:1n7) (see all 10)----
    PA(16:0/18:1(9Z))PA(16:0/18:1n9) (see all 10)----
    PA(16:0/18:2(9Z,12Z))PA(34:2) (see all 10)----
    PA(16:0e/18:0)2-octadecanoyl-1-hexadecyl-sn-glycero-3-phosphate ;PA(o-16:0/18:0) ----
    PA(18:0/18:2(9Z,12Z))PA(36:2) (see all 10)----
    PA(18:1(11Z)/18:1(11Z))PA(36:2) (see all 10)----
    PA(18:1(11Z)/18:1(9Z))PA(36:2) (see all 10)----
    PA(18:1(9Z)/18:1(11Z))PA(36:2) (see all 10)----

    1 PharmGKB related drug/compound annotation for AGAP2 gene    About this table
    Drug/compound PharmGKB Annotation
    somatropin recombinantCA  



    AGAP2 for compounds           About GeneDecksing



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
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    REFSEQ mRNAs for AGAP2 gene (2 alternative transcripts): 
    NM_001122772.2  NM_014770.3  

    Unigene Cluster for AGAP2:

    ArfGAP with GTPase domain, ankyrin repeat and PH domain 2
    Hs.302435  [show with all ESTs]
    Unigene Representative Sequence: NM_001122772
    4 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000328568(uc001spq.3 uc001spp.3) ENST00000257897(uc001spr.3)
    ENST00000547588 ENST00000549129

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    Selected qRT-PCR Assays for microRNAs that regulate AGAP2 (see all 63):
    hsa-miR-1321 hsa-miR-3194-5p hsa-miR-136 hsa-miR-520e hsa-miR-302d hsa-miR-1914* hsa-miR-513a-5p hsa-miR-624
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    GenScript: all cDNA clones in your preferred vector (see all 2): AGAP2 (NM_014770)
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      QuantiFast Probe-based Assays in human, mouse, rat AGAP2

    Additional mRNA sequence: 

    AF384128.1 AF413077.1 AK122827.1 AK292672.1 AY128689.1 BC028020.1 D79989.1 

    8 DOTS entries:

    DT.110116  DT.100781647  DT.99999099  DT.100781650  DT.100727113  DT.97843575  DT.100835143  DT.92428865 

    Selected AceView cDNA sequences (see all 67):

    AK122827 AL120358 BU198064 BQ935205 BC028020 NM_014770 AF384128 D79989 
    BU198063 AA772779 AI948875 AF413077 CR625050 AL560115 AA939069 BF529135 
    BM726931 BI755875 BI910944 AW016402 AI654376 BV205580 BG682882 AL134589 

    GeneLoc Exon Structure

    3 Alternative Splicing Database (ASD) splice patterns (SP) for AGAP2    About this scheme

    ExUns: 1 ^ 2a · 2b ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11 ^ 12 ^ 13 ^ 14 ^ 15 ^ 16 ^ 17 ^ 18 ^ 19 ^ 20a · 20b · 20c
    SP1:                                                                                                                                          
    SP2:                                                                                                                                          
    SP3:        -     -                                                                             -                                             


    ECgene alternative splicing isoforms for AGAP2

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    AGAP2 expression in normal human tissues (normalized intensities)      AGAP2 embryonic expression: see
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: GGGATGGGGG
    AGAP2 Expression
    About this image


    AGAP2 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     
     Brain (Nervous System)
             Cerebral Cortex
    AGAP2 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    AGAP2 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.302435

    UniProtKB/Swiss-Prot: AGAP2_HUMAN, Q99490
    Tissue specificity: Isoform 1 is brain-specific. Isoform 2 is ubiquitously expressed, with highest levels in brain
    and heart

        Custom PCR Arrays for AGAP2
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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of animals.

    Orthologs for AGAP2 gene from Selected species (see all 13)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Agap21 , 5 ArfGAP with GTPase domain, ankyrin repeat and PH domain more1, 5 88.81(n)1
    93.76(a)1
      10 (74.50 cM)5
    2164391  NM_001033263.41  NP_001028435.11 
     1270789075 
    chicken
    (Gallus gallus)
    Aves --
    Uncharacterized protein
    15(a)
    many ↔ many
    20(1343160-1364227)
    lizard
    (Anolis carolinensis)
    Reptilia AGAP26
    ArfGAP with GTPase domain, ankyrin repeat and PH d...
    58(a)
    1 ↔ 1
    2(66469382-66556664)
    tropical clawed frog
    (Xenopus tropicalis)
    Amphibia LOC1004969971 mucin-19-like 61.38(n)
    64.09(a)
      100496997  XM_002933688.2  XP_002933734.2 
    zebrafish
    (Danio rerio)
    Actinopterygii agap21 ArfGAP with GTPase domain, ankyrin repeat and PH domain more 60.14(n)
    59.25(a)
      565109  NM_001080018.1  NP_001073487.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta Asap16
    ArfGAP with SH3 domain, ankyrin repeat and PH doma...
    14(a)
    1 → many
    2R(4001791-4010357)


    ENSEMBL Gene Tree for AGAP2 (if available)
    TreeFam Gene Tree for AGAP2 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for AGAP2 gene
    AGAP52  AGAP62  ASAP12  ARAP32  ACAP22  ACAP32  ASAP22  ARAP12  
    AGAP32  ARAP22  AGAP42  AGAP12  AGAP82  ACAP12  AGAP72  AGAP102  
    AGAP92  ASAP32  
    17 SIMAP similar genes for AGAP2 using alignment to 4 protein entries:     AGAP2_HUMAN (see all proteins):
    CENTG2    AGAP1    CENTG3    DKFZp761E2216    AGAP3    AGAP10
    AGAP11    CTGLF11P    ARFGAP3    AGAP8    AGAP4    AGAP5
    AGAP9    AGAP6    AGAP7    FLJ00312    ARFGAP1

    AGAP2 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for AGAP2 (see all 422)    About this table    
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 12 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    VAR_0264414
    A glioblastoma cell line4--see VAR_0264412 A V mis40--------
    VAR_0264454
    A glioblastoma cell line4--see VAR_0264452 S P mis40--------
    VAR_0361844
    A breast cancer sample4--see VAR_0361842 D Y mis40--------
    VAR_0264424
    A glioblastoma cell line4--see VAR_0264422 E V mis40--------
    VAR_0264384
    A glioblastoma cell line4--see VAR_0264382 V A mis40--------
    VAR_0361834
    A breast cancer sample4--see VAR_0361832 T A mis40--------
    VAR_0264444
    A sarcoma cell line4--see VAR_0264442 V M mis40--------
    VAR_0264394
    A sarcoma cell line4--see VAR_0264392 R G mis40--------
    VAR_0264434
    A glioblastoma cell line4--see VAR_0264432 N D mis40--------
    rs2000440651,2
    C--55155980(-) CCGGTC/TTNNNN 2 -- ut310--------

    HapMap Linkage Disequilibrium report for AGAP2 (58118980 - 58135940 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 10 variations for AGAP2:    About this table    
    Variant IDTypeSubtypePubMed ID
    nsv899121CNV Loss21882294
    nsv899123CNV Loss21882294
    nsv470296CNV Loss18288195
    nsv899122CNV Loss21882294
    nsv510601CNV Loss20534489
    nsv470297CNV Gain18288195
    nsv826384CNV Gain20364138
    nsv826383CNV Gain20364138
    nsv826386CNV Gain20364138
    nsv826385CNV Gain20364138

    Site Specific Mutation Identification with PCR Assays
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    DNA2.0 Custom Variant and Variant Library Synthesis for AGAP2

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 605476    OMIM disorders: --

    11 diseases for AGAP2:    About MalaCards
    anisakiasis    diphyllobothriasis    lymphosarcoma    breast and colorectal cancer
    multiple sclerosis    prostate cancer    prostatitis    hiv-1
    squamous cell carcinoma    neuronitis    colorectal cancer

    3 diseases from the University of Copenhagen DISEASES database for AGAP2:
    Diphyllobothriasis     Anisakiasis     Lymphosarcoma

    AGAP2 for disorders           About GeneDecksing


    Congresses - knowledge worth sharing:
    The International Symposium on Pneumococci and Pneumococcal Diseases (ISPPD) 9 - 13 March 2014

    1 Novoseek inferred disease relationship for AGAP2 gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    cancer 28.5 3 19318351 (1), 20419274 (1), 17367500 (1)

    Genetic Association Database (GAD): AGAP2
    Human Genome Epidemiology (HuGE) Navigator: AGAP2 (2 documents)

    Export disorders for AGAP2 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for AGAP2 gene, integrated from 10 sources (see all 47):
    (articles sorted by number of sources associating them with AGAP2)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. The Arf GAPs AGAP1 and AGAP2 distinguish between the adaptor protein complexes AP-1 and AP-3. (PubMed id 16079295)1, 2, 9 Nie Z.... Randazzo P.A. (J. Cell Sci. 2005)
    2. Genetic alteration and expression of the phosphoinositol-3-kinase/Akt pathway genes PIK3CA and PIKE in human glioblastomas. (PubMed id 16150119)1, 2, 9 Knobbe C.B.... Reifenberger G. (Neuropathol. Appl. Neurobiol. 2005)
    3. The centaurin gamma-1 GTPase-like domain functions as an NTPase. (PubMed id 17037982)1, 2, 9 Soundararajan M.... Doyle D.A. (Biochem. J. 2007)
    4. PIKE (phosphatidylinositol 3-kinase enhancer)-A GTPase stimulates Akt activity and mediates cellular invasion. (PubMed id 14761976)1, 2, 9 Ahn J.-Y.... Ye K. (J. Biol. Chem. 2004)
    5. Split pleckstrin homology domain-mediated cytoplasmic-nuclear localization of PI3-kinase enhancer GTPase. (PubMed id 18371979)1, 2 Yan J.... Zhang M. (J. Mol. Biol. 2008)
    6. Src-family tyrosine kinase fyn phosphorylates phosphatidylinositol 3- kinase enhancer-activating Akt, preventing its apoptotic cleavage and promoting cell survival. (PubMed id 16841086)1, 2 Tang X.... Ye K. (Cell Death Differ. 2007)
    7. Phosphoinositol lipids bind to phosphatidylinositol 3 (PI3)-kinase enhancer GTPase and mediate its stimulatory effect on PI3-kinase and Akt signalings. (PubMed id 16263930)1, 2 Hu Y.... Ye K. (Proc. Natl. Acad. Sci. U.S.A. 2005)
    8. PIKE-A is amplified in human cancers and prevents apoptosis by up- regulating Akt. (PubMed id 15118108)1, 2 Ahn J.-Y.... Ye K. (Proc. Natl. Acad. Sci. U.S.A. 2004)
    9. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (Nat. Genet. 2004)
    10. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 116986 HGNC: 16921 AceView: CENTG1 Ensembl:ENSG00000135439 euGenes: HUgn116986
    ECgene: AGAP2 Kegg: 116986 H-InvDB: AGAP2

    (According to HUGE)
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    HUGE: KIAA0167

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for AGAP2 Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for AGAP2 Genetics and Cytogenetics in Oncology and Haematology

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for AGAP2 gene:
    Search GeneIP for patents involving AGAP2

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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