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Aliases for AGAP2 Gene

Aliases for AGAP2 Gene

  • ArfGAP With GTPase Domain, Ankyrin Repeat And PH Domain 2 2 3
  • PIKE 3 4 6
  • Phosphatidylinositol 3-Kinase Enhancer 3 4
  • Centaurin, Gamma 1 2 3
  • Cnt-G1 3 4
  • CENTG1 3 4
  • GGAP2 3 4
  • Arf GAP With GTP-Binding Protein-Like, ANK Repeat And PH Domains 2 3
  • Arf-GAP With GTPase, ANK Repeat And PH Domain-Containing Protein 2 3
  • GTP-Binding And GTPase Activating Protein 2 3
  • GTP-Binding And GTPase-Activating Protein 2 4
  • Phosphatidylinositol-3-Kinase Enhancer 3
  • Phosphoinositide 3-Kinase Enhancer 3
  • Centaurin-Gamma-1 4
  • KIAA0167 4
  • AGAP-2 4

External Ids for AGAP2 Gene

Previous Symbols for AGAP2 Gene

  • CENTG1

Summaries for AGAP2 Gene

Entrez Gene Summary for AGAP2 Gene

  • The protein encoded by this gene belongs to the centaurin gamma-like family. It mediates anti-apoptotic effects of nerve growth factor by activating nuclear phosphoinositide 3-kinase. It is overexpressed in cancer cells, and promotes cancer cell invasion. Alternatively spliced transcript variants encoding different isoforms have been described for this gene. [provided by RefSeq, Aug 2011]

GeneCards Summary for AGAP2 Gene

AGAP2 (ArfGAP With GTPase Domain, Ankyrin Repeat And PH Domain 2) is a Protein Coding gene. Diseases associated with AGAP2 include diphyllobothriasis and anisakiasis. Among its related pathways are L1CAM interactions and Endocytosis. GO annotations related to this gene include GTP binding. An important paralog of this gene is ASAP3.

UniProtKB/Swiss-Prot for AGAP2 Gene

  • GTPase-activating protein (GAP) for ARF1 and ARF5, which also shows strong GTPase activity. Isoform 1 participates in the prevention of neuronal apoptosis by enhancing PI3 kinase activity. It aids the coupling of metabotropic glutamate receptor 1 (GRM1) to cytoplasmic PI3 kinase by interacting with Homer scaffolding proteins, and also seems to mediate anti-apoptotic effects of NGF by activating nuclear PI3 kinase. Isoform 2 does not stimulate PI3 kinase but may protect cells from apoptosis by stimulating Akt. It also regulates the adapter protein 1 (AP-1)-dependent trafficking of proteins in the endosomal system. It seems to be oncogenic. It is overexpressed in cancer cells, prevents apoptosis and promotes cancer cell invasion.

Gene Wiki entry for AGAP2 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for AGAP2 Gene

Genomics for AGAP2 Gene

Genomic Location for AGAP2 Gene

Start:
57,723,761 bp from pter
End:
57,742,201 bp from pter
Size:
18,441 bases
Orientation:
Minus strand

Genomic View for AGAP2 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for AGAP2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for AGAP2 Gene

Regulatory Elements for AGAP2 Gene

Transcription factor binding sites by QIAGEN in the AGAP2 gene promoter:

Proteins for AGAP2 Gene

  • Protein details for AGAP2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q99490-AGAP2_HUMAN
    Recommended name:
    Arf-GAP with GTPase, ANK repeat and PH domain-containing protein 2
    Protein Accession:
    Q99490
    Secondary Accessions:
    • A8K9F7
    • O00578
    • Q548E0
    • Q8IWU3

    Protein attributes for AGAP2 Gene

    Size:
    1192 amino acids
    Molecular mass:
    124674 Da
    Quaternary structure:
    • Isoform 1 interacts with EPB41L1, PLCG1, NF2, HOMER1 and HOMER2 (By similarity). Isoform 2 interacts with activated AKT1 in the presence of guanine nucleotides, and with the AP-1 complex.
    SequenceCaution:
    • Sequence=BAA11484.2; Type=Erroneous initiation; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for AGAP2 Gene

    Alternative splice isoforms for AGAP2 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for AGAP2 Gene

Proteomics data for AGAP2 Gene at MOPED

Post-translational modifications for AGAP2 Gene

  • Isoform PIKE-A is phosphorylated at Tyr-682 and Tyr-774 by FYN, preventing its apoptotic cleavage
  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for AGAP2 Gene

ENSEMBL proteins:
Reactome Protein details:
REFSEQ proteins:

No data available for DME Specific Peptides for AGAP2 Gene

Domains for AGAP2 Gene

Gene Families for AGAP2 Gene

HGNC:
  • PLEKH :Pleckstrin homology (PH) domain containing
  • ArfGAP :ADP-ribosylation factor GTPase activating proteins
  • ANKRD :Ankyrin repeat domain containing

UniProtKB/Swiss-Prot:

AGAP2_HUMAN
Domain:
  • G domain binds GTP and has GTPase activity:
    • Q99490
  • Arf-GAP domain interacts with G domain and may regulate its GTPase activity:
    • Q99490
  • Although both PH domains of isoforms 1 and 2 bind phospholipids, they differently regulate subcellular location. PH domain of isoform 1 directs the protein to the nucleus, but PH domain of isoform 2 directs it to the cytosol. PH domain of isoform 2 is required for binding to AP-1:
    • Q99490
  • Contains 1 Arf-GAP domain.:
    • Q99490
  • Contains 1 PH domain.:
    • Q99490
Family:
  • Belongs to the centaurin gamma-like family.:
    • Q99490
Similarity:
  • Contains 2 ANK repeats.:
    • Q99490
genes like me logo Genes that share domains with AGAP2: view

Function for AGAP2 Gene

Molecular function for AGAP2 Gene

UniProtKB/Swiss-Prot EnzymeRegulation: GAP activity is stimulated by phosphatidylinositol 4,5-bisphosphate (PIP2) and, to a lesser extent, by phosphatidylinositol 3,4,5-trisphosphate (PIP3). Phosphatidic acid potentiates PIP2 stimulation
UniProtKB/Swiss-Prot Function: GTPase-activating protein (GAP) for ARF1 and ARF5, which also shows strong GTPase activity. Isoform 1 participates in the prevention of neuronal apoptosis by enhancing PI3 kinase activity. It aids the coupling of metabotropic glutamate receptor 1 (GRM1) to cytoplasmic PI3 kinase by interacting with Homer scaffolding proteins, and also seems to mediate anti-apoptotic effects of NGF by activating nuclear PI3 kinase. Isoform 2 does not stimulate PI3 kinase but may protect cells from apoptosis by stimulating Akt. It also regulates the adapter protein 1 (AP-1)-dependent trafficking of proteins in the endosomal system. It seems to be oncogenic. It is overexpressed in cancer cells, prevents apoptosis and promotes cancer cell invasion.

Gene Ontology (GO) - Molecular Function for AGAP2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005096 GTPase activator activity IEA --
GO:0005515 protein binding IPI 20075866
GO:0005525 GTP binding IEA --
GO:0008270 zinc ion binding IEA --
GO:0019901 protein kinase binding --
genes like me logo Genes that share ontologies with AGAP2: view
genes like me logo Genes that share phenotypes with AGAP2: view

Animal Models for AGAP2 Gene

MGI Knock Outs for AGAP2:

No data available for Enzyme Numbers (IUBMB) , miRNA , Transcription Factor Targeting and HOMER Transcription for AGAP2 Gene

Localization for AGAP2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for AGAP2 Gene

Isoform 1: Cytoplasm. Nucleus.
Isoform 2: Cytoplasm.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for AGAP2 Gene COMPARTMENTS Subcellular localization image for AGAP2 gene
Compartment Confidence
nucleus 5
mitochondrion 4
cytoskeleton 1
cytosol 1
endosome 1
extracellular 1
plasma membrane 1

Gene Ontology (GO) - Cellular Components for AGAP2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005622 intracellular --
GO:0005634 nucleus ISS 11136977
GO:0005730 nucleolus IDA --
GO:0005739 mitochondrion IDA --
GO:0016020 membrane IDA 19946888
genes like me logo Genes that share ontologies with AGAP2: view

Pathways for AGAP2 Gene

genes like me logo Genes that share pathways with AGAP2: view

Pathways by source for AGAP2 Gene

1 GeneGo (Thomson Reuters Life Sciences Research) pathway for AGAP2 Gene
3 Reactome pathways for AGAP2 Gene
2 KEGG pathways for AGAP2 Gene

Gene Ontology (GO) - Biological Process for AGAP2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006184 obsolete GTP catabolic process --
GO:0007165 signal transduction --
GO:0007264 small GTPase mediated signal transduction IEA --
GO:0007411 axon guidance TAS --
GO:0014068 positive regulation of phosphatidylinositol 3-kinase signaling --
genes like me logo Genes that share ontologies with AGAP2: view

Compounds for AGAP2 Gene

(13) HMDB Compounds for AGAP2 Gene

Compound Synonyms Cas Number PubMed IDs
Guanosine triphosphate
  • 5'-GTP
86-01-1
PA(16:0/16:0)
  • Dipalmitoylphosphatidic acid
7091-44-3
PA(16:0/18:1(11Z))
  • PA(16:0/18:1n7)
Not Available
PA(16:0/18:1(9Z))
  • PA(16:0/18:1n9)
Not Available
PA(16:0/18:2(9Z,12Z))
  • PA(34:2)
Not Available

(1) PharmGKB related drug/compound annotations for AGAP2 Gene

Drug/compound Annotation
somatropin recombinant CA
genes like me logo Genes that share compounds with AGAP2: view

Transcripts for AGAP2 Gene

Unigene Clusters for AGAP2 Gene

ArfGAP with GTPase domain, ankyrin repeat and PH domain 2:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for AGAP2 Gene

ExUns: 1 ^ 2a · 2b ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11 ^ 12 ^ 13 ^ 14 ^ 15 ^ 16 ^ 17 ^ 18 ^ 19 ^ 20a · 20b · 20c
SP1:
SP2:
SP3: - - -

Relevant External Links for AGAP2 Gene

GeneLoc Exon Structure for
AGAP2
ECgene alternative splicing isoforms for
AGAP2

Expression for AGAP2 Gene

mRNA expression in normal human tissues for AGAP2 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for AGAP2 Gene

This gene is overexpressed in Brain - Cortex (5.7), Brain - Cerebellum (5.4), Brain - Nucleus accumbens (basal ganglia) (4.9), Brain - Anterior cingulate cortex (BA24) (4.7), Brain - Hippocampus (4.6), Brain - Cerebellar Hemisphere (4.6), Brain - Amygdala (4.3), and Brain - Frontal Cortex (BA9) (4.1).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for AGAP2 Gene

SOURCE GeneReport for Unigene cluster for AGAP2 Gene Hs.302435

mRNA Expression by UniProt/SwissProt for AGAP2 Gene

Q99490-AGAP2_HUMAN
Tissue specificity: Isoform 1 is brain-specific. Isoform 2 is ubiquitously expressed, with highest levels in brain and heart.
genes like me logo Genes that share expressions with AGAP2: view

Orthologs for AGAP2 Gene

This gene was present in the common ancestor of animals.

Orthologs for AGAP2 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia AGAP2 36
  • 98.03 (n)
  • 97.74 (a)
AGAP2 37
  • 100 (a)
OneToOne
cow
(Bos Taurus)
Mammalia AGAP2 36
  • 92.59 (n)
  • 95.79 (a)
AGAP2 37
  • 96 (a)
OneToOne
dog
(Canis familiaris)
Mammalia AGAP2 37
  • 90 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Agap2 36
  • 88.81 (n)
  • 93.76 (a)
Agap2 16
Agap2 37
  • 95 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia AGAP2 37
  • 14 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia AGAP2 37
  • 81 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Agap2 36
  • 88.67 (n)
  • 93.76 (a)
chicken
(Gallus gallus)
Aves -- 37
  • 15 (a)
ManyToMany
lizard
(Anolis carolinensis)
Reptilia AGAP2 37
  • 58 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia LOC100496997 36
  • 61.38 (n)
  • 64.09 (a)
zebrafish
(Danio rerio)
Actinopterygii agap2 36
  • 60.14 (n)
  • 59.25 (a)
agap2 37
  • 53 (a)
OneToOne
fruit fly
(Drosophila melanogaster)
Insecta Asap1 37
  • 14 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea CSA.5006 37
  • 15 (a)
OneToMany
Species with no ortholog for AGAP2:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for AGAP2 Gene

ENSEMBL:
Gene Tree for AGAP2 (if available)
TreeFam:
Gene Tree for AGAP2 (if available)

Paralogs for AGAP2 Gene

genes like me logo Genes that share paralogs with AGAP2: view

Variants for AGAP2 Gene

Sequence variations from dbSNP and Humsavar for AGAP2 Gene

SNP ID Clin Chr 12 pos Sequence Context AA Info Type MAF
rs238516 -- 57,723,572(-) AGCTC(A/G)CCCTG downstream-variant-500B
rs238517 -- 57,723,954(+) AGGAG(G/T)GGAGC downstream-variant-500B, utr-variant-3-prime, nc-transcript-variant
rs238518 -- 57,724,046(+) CTCTT(C/G)TCGCT downstream-variant-500B, utr-variant-3-prime, intron-variant
rs238523 -- 57,731,020(+) GTCAA(C/T)ATGGT intron-variant
rs238524 -- 57,733,549(-) TCTCA(A/G)AGAAG intron-variant

Structural Variations from Database of Genomic Variants (DGV) for AGAP2 Gene

Variant ID Type Subtype PubMed ID
nsv899121 CNV Loss 21882294
nsv470296 CNV Loss 18288195
nsv826383 CNV Gain 20364138
nsv899122 CNV Loss 21882294
nsv899123 CNV Loss 21882294
nsv826384 CNV Gain 20364138
nsv826385 CNV Gain 20364138
nsv510601 CNV Loss 20534489
nsv470297 CNV Gain 18288195
nsv826386 CNV Gain 20364138

Relevant External Links for AGAP2 Gene

HapMap Linkage Disequilibrium report
AGAP2

Disorders for AGAP2 Gene

(3) University of Copenhagen DISEASES for AGAP2 Gene

(1) Novoseek inferred disease relationships for AGAP2 Gene

Disease -log(P) Hits PubMed IDs
cancer 28.5 3

Relevant External Links for AGAP2

Genetic Association Database (GAD)
AGAP2
Human Genome Epidemiology (HuGE) Navigator
AGAP2
genes like me logo Genes that share disorders with AGAP2: view

No data available for UniProtKB/Swiss-Prot for AGAP2 Gene

Publications for AGAP2 Gene

  1. The Arf GAPs AGAP1 and AGAP2 distinguish between the adaptor protein complexes AP-1 and AP-3. (PMID: 16079295) Nie Z. … Randazzo P.A. (J. Cell Sci. 2005) 3 4 23
  2. Genetic alteration and expression of the phosphoinositol-3-kinase/Akt pathway genes PIK3CA and PIKE in human glioblastomas. (PMID: 16150119) Knobbe C.B. … Reifenberger G. (Neuropathol. Appl. Neurobiol. 2005) 3 4 23
  3. The centaurin gamma-1 GTPase-like domain functions as an NTPase. (PMID: 17037982) Soundararajan M. … Doyle D.A. (Biochem. J. 2007) 3 4 23
  4. PIKE (phosphatidylinositol 3-kinase enhancer)-A GTPase stimulates Akt activity and mediates cellular invasion. (PMID: 14761976) Ahn J.-Y. … Ye K. (J. Biol. Chem. 2004) 3 4 23
  5. PIKE GTPase signaling and function. (PMID: 15951849) Ahn J.Y. … Ye K. (Int. J. Biol. Sci. 2005) 3 23

Products for AGAP2 Gene

Sources for AGAP2 Gene

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