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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

AGAP11 Gene

protein-coding   GIFtS: 38
GCID: GC10P088720

Ankyrin Repeat And GTPase Domain Arf GTPase Activating Protein...

  Search for AGAP11
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
Ankyrin Repeat And GTPase Domain Arf GTPase Activating Protein 111 2
AGAP-112 3
Arf-GAP With GTPase, ANK Repeat And PH Domain-Containing Protein 112
KIAA19753
Centaurin-Gamma-Like Protein KIAA19753

External Ids:    HGNC: 294211   Entrez Gene: 1193852   Ensembl: ENSG000001513037   UniProtKB: Q8TF273   

Export aliases for AGAP11 gene to outside databases

Previous GC identifer: GC10P082584


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

GeneCards Summary for AGAP11 Gene: 
AGAP11 (ankyrin repeat and GTPase domain Arf GTPase activating protein 11) is a protein-coding gene. GO annotations related to this gene include phospholipid binding and ARF GTPase activator activity. An important paralog of this gene is AGAP5.

UniProtKB/Swiss-Prot: AGA11_HUMAN, Q8TF27
Function: Putative GTPase-activating protein (Potential)




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000010.10  NT_030059.13  NC_018921.2  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the AGAP11 gene promoter:
         STAT1   AML1a   STAT1beta   STAT1alpha   C/EBPalpha   S8   PPAR-gamma1   HSF2   PPAR-gamma2   
         Other transcription factors

Browse SwitchGear Promoter luciferase reporter plasmids
   Search SABiosciences Chromatin IP Primers for AGAP11

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat AGAP11


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 10q23.2   Ensembl cytogenetic band:  10q23.2   HGNC cytogenetic band: 10q23.2

AGAP11 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
AGAP11 gene location

GeneLoc information about chromosome 10         GeneLoc Exon Structure

GeneLoc location for GC10P088720:  view genomic region     (about GC identifiers)

Start:
88,730,498 bp from pter      End:
88,769,960 bp from pter
Size:
39,463 bases      Orientation:
plus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: AGA11_HUMAN, Q8TF27 (See protein sequence)
Recommended Name: Arf-GAP with GTPase, ANK repeat and PH domain-containing protein 11  
Size: 550 amino acids; 60549 Da
Sequence caution: Sequence=BAB85561.1; Type=Erroneous initiation;
Secondary accessions: B9EIP7 D3DWE4

Explore the universe of human proteins at neXtProt for AGAP11: NX_Q8TF27

Post-translational modifications:

  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_Q8TF27

  • AGAP11 Protein expression data from MOPED1, PaxDb2 and MAXQB3 : --
    REFSEQ proteins: NP_597704.1  
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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    HGNC Gene Families: 
    ANKRD: Ankyrin repeat domain containing
    ArfGAP: ADP-ribosylation factor GTPase activating proteins

    5 InterPro protein domains:
     IPR001849 Pleckstrin_homology
     IPR001164 ArfGAP
     IPR020683 Ankyrin_rpt-contain_dom
     IPR011993 PH_like_dom
     IPR002110 Ankyrin_rpt

    Graphical View of Domain Structure for InterPro Entry Q8TF27

    ProtoNet protein and cluster: Q8TF27

    3 Blocks protein domains:
    IPB001164 HIV Rev interacting protein signature
    IPB001849 Pleckstrin-like
    IPB002110 Ankyrin repeat signature


    UniProtKB/Swiss-Prot: AGA11_HUMAN, Q8TF27
    Similarity: Belongs to the centaurin gamma-like family
    Similarity: Contains 2 ANK repeats
    Similarity: Contains 1 Arf-GAP domain
    Similarity: Contains 1 PH domain


    AGAP11 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: AGA11_HUMAN, Q8TF27
    Function: Putative GTPase-activating protein (Potential)

         Gene Ontology (GO): 3 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005543phospholipid binding IEA--
    GO:0008060ARF GTPase activator activity IEA--
    GO:0008270zinc ion binding IEA--
         
    AGAP11 for ontologies           About GeneDecksing


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    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section



    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for AGAP11

    Gene Ontology (GO): 1 biological process term (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0032312regulation of ARF GTPase activity IEA--

    AGAP11 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for AGAP11 (AGA11)

    Search CenterWatch for drugs/clinical trials and news about AGAP11 / AGA11

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
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    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for AGAP11 gene: 
    NM_133447.1  

    Unigene Cluster for AGAP11:

    Ankyrin repeat and GTPase domain Arf GTPase activating protein 11
    Hs.511787  [show with all ESTs]
    Unigene Representative Sequence: NM_133447
    1 Ensembl transcript including schematic representation, and UCSC links where relevant:
    ENST00000444431(uc001kee.2)
    miRNA
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    Additional mRNA sequence: 

    AK097165.1 BC062776.1 BC140762.1 

    4 DOTS entries:

    DT.100058943  DT.100058139  DT.100858878  DT.95194678 

    24/267 AceView cDNA sequences (see all 267):

    AJ346418 CB107161 CA434240 AA878084 CB045310 BQ219402 BM838642 AA486472 
    BQ694475 NM_006829 BM748818 AW006481 AI434794 BE566379 BU728272 H49348 
    AB075855 BM693306 BI836596 BM668990 BM704419 F30398 CA406377 BE299889 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    AGAP11 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: --
    AGAP11 Expression
    About this image


    Genevestigator expression for AGAP11

    SOURCE GeneReport for Unigene cluster: Hs.511787
        SABiosciences Custom PCR Arrays for AGAP11
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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for AGAP11

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of human and chimp.

    Orthologs for AGAP11 gene from 1 species (see representative species )    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    chimpanzee
    (Pan troglodytes)
    Mammalia CTGLF21 ArfGAP with GTPase domain, ankyrin repeat and PH domain more 97.7(n)
    95.25(a)
      737901  XM_001141368.3  XP_001141368.3 


    ENSEMBL Gene Tree for AGAP11 (if available)
    TreeFam Gene Tree for AGAP11 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for AGAP11 gene
    AGAP5  AGAP8  AGAP4  AGAP10  AGAP6  AGAP7  AGAP9  
    17 SIMAP similar genes for AGAP11 using alignment to 2 protein entries:     AGA11_HUMAN (see all proteins):
    AGAP4    AGAP5    AGAP7    AGAP8    AGAP6    CENTG2
    CTGLF11P    AGAP9    AGAP1    AGAP10    FLJ00312    DKFZp761E2216
    AGAP3    CENTG3    AGAP2    ARFGAP1    ARFGAP3

    AGAP11 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/784 SNPs in AGAP11 are shown (see all 784)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 10 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs12403761,2
    C,F,A,H--88733150(-) tgcgaT/Ctaaac 1 -- int117Minor allele frequency- C:0.32NS EA NA WA 898
    rs12403751,2
    C,F,A,H--88733192(-) ggagaA/Gagatt 1 -- int123Minor allele frequency- G:0.34NS EA NA WA 2346
    rs127833211,2
    C,F,A,H--88733275(+) AGTGCA/GGAGTG 1 -- int116Minor allele frequency- G:0.28NS EA NA WA CSA 792
    rs1896670441,2
    --88733333(+) ATGTTC/GTTCTG 1 -- int10--------
    rs1172904631,2
    C,F--88733443(+) TCTGAA/CGGCCA 1 -- int11Minor allele frequency- C:0.03EA 120
    rs127716141,2
    C,F--88733536(+) attagC/Tcgggt 1 -- int13Minor allele frequency- T:0.50NA 6
    rs1117406701,2
    C,F--88733596(+) GAATTG/TCTTGA 1 -- int11Minor allele frequency- T:0.50WA 2
    rs784722301,2
    F--88733731(+) TTCCTA/GAACAA 1 -- int11Minor allele frequency- G:0.01WA 118
    rs79132091,2
    C--88733748(+) atgatG/Tctaac 1 -- int10--------
    rs754600991,2
    C,F--88733775(+) GTGGGA/TACAGT 1 -- int12Minor allele frequency- T:0.04WA 120

    HapMap Linkage Disequilibrium report for AGAP11 (88730498 - 88769960 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 10/15 variations for AGAP11 (see all 15):    About this table     
    Variant IDTypeSubtypePubMed ID
    esv2664328CNV Deletion23128226
    dgv797n71CNV Loss21882294
    nsv428236CNV Loss18775914
    nsv895858CNV Loss21882294
    esv27213CNV Loss19812545
    nsv8712CNV Loss18304495
    nsv470969CNV Loss18288195
    nsv831939CNV Gain17160897
    nsv517487CNV Gain+Loss19592680
    essv23924CNV CNV17122850

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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
      --

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for AGAP11 gene integrated from 9 sources:
    (articles sorted by number of sources associating them with AGAP11)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Prediction of the coding sequences of unidentified human genes. XXII. The complete sequences of 50 new cDNA clones which code for large proteins. (PubMed id 11853319)1, 2, 3 Nagase T.... Ohara O. (2001)
    2. A germline-specific class of small RNAs binds mammali an Piwi proteins. (PubMed id 16751776)1 Girard A....Carmell M.A. (2006)
    3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)2 Gerhard D.S....Malek J. (2004)
    4. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1 Ota T.... Sugano S. (2004)
    5. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (2002)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 119385 HGNC: 29421 AceView: SNCGandC10orf116andKIAA1975 Ensembl:ENSG00000151303 euGenes: HUgn119385
    ECgene: AGAP11 H-InvDB: AGAP11

    (According to HUGE)
    About This Section
    HUGE: KIAA1975

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for AGAP11 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for AGAP11 gene:
    Search GeneIP for patents involving AGAP11

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0 and Sirion Biotech, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Sirion Biotech, Cell lines from GenScript, and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
    About This Section

     
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    GeneCards Homepage - Last full update: 23 Oct 2013 - Incrementals: 4 Nov 2013 , 7 Nov 2013 , 23 Jan 2014

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    Category
    (GIFtS: 73)
    transforming growth factor, beta 1
    GIFtS Group
    The GeneCards human gene database gene index: 1 3 5 6 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z 


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