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Aliases for AGAP11 Gene

Aliases for AGAP11 Gene

  • ArfGAP With GTPase Domain, Ankyrin Repeat And PH Domain 11 2 3 5
  • Ankyrin Repeat And GTPase Domain Arf GTPase Activating Protein 11 2 3
  • AGAP-11 3 4
  • Arf-GAP With GTPase, ANK Repeat And PH Domain-Containing Protein 11 3
  • Centaurin-Gamma-Like Protein KIAA1975 4
  • KIAA1975 4

External Ids for AGAP11 Gene

Previous GeneCards Identifiers for AGAP11 Gene

  • GC10P088720
  • GC10P082584

Summaries for AGAP11 Gene

GeneCards Summary for AGAP11 Gene

AGAP11 (ArfGAP With GTPase Domain, Ankyrin Repeat And PH Domain 11) is a Protein Coding gene. GO annotations related to this gene include GTPase activator activity. An important paralog of this gene is AGAP5.

UniProtKB/Swiss-Prot for AGAP11 Gene

  • Putative GTPase-activating protein.

Additional gene information for AGAP11 Gene

No data available for Entrez Gene Summary , CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for AGAP11 Gene

Genomics for AGAP11 Gene

Regulatory Elements for AGAP11 Gene

Promoters for AGAP11 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

Genomic Locations for AGAP11 Gene

Genomic Locations for AGAP11 Gene
39,463 bases
Plus strand

Genomic View for AGAP11 Gene

Genes around AGAP11 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
AGAP11 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for AGAP11 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for AGAP11 Gene

Proteins for AGAP11 Gene

  • Protein details for AGAP11 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Arf-GAP with GTPase, ANK repeat and PH domain-containing protein 11
    Protein Accession:
    Secondary Accessions:
    • B9EIP7
    • D3DWE4

    Protein attributes for AGAP11 Gene

    550 amino acids
    Molecular mass:
    60549 Da
    Quaternary structure:
    No Data Available
    • Sequence=BAB85561.1; Type=Erroneous initiation; Evidence={ECO:0000305};

neXtProt entry for AGAP11 Gene

Post-translational modifications for AGAP11 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for AGAP11 Gene

REFSEQ proteins:

No data available for DME Specific Peptides for AGAP11 Gene

Domains & Families for AGAP11 Gene

Suggested Antigen Peptide Sequences for AGAP11 Gene

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the centaurin gamma-like family.
  • Belongs to the centaurin gamma-like family.
genes like me logo Genes that share domains with AGAP11: view

Function for AGAP11 Gene

Molecular function for AGAP11 Gene

UniProtKB/Swiss-Prot Function:
Putative GTPase-activating protein.

Phenotypes From GWAS Catalog for AGAP11 Gene

Gene Ontology (GO) - Molecular Function for AGAP11 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005096 GTPase activator activity IEA --
GO:0046872 metal ion binding IEA --
genes like me logo Genes that share ontologies with AGAP11: view

Clone Products

No data available for Enzyme Numbers (IUBMB) , Phenotypes , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for AGAP11 Gene

Localization for AGAP11 Gene

No data available for Subcellular locations from UniProtKB/Swiss-Prot , Subcellular locations from COMPARTMENTS , Subcellular locations from the Human Protein Atlas (HPA) and Gene Ontology (GO) - Cellular Components for AGAP11 Gene

Pathways & Interactions for AGAP11 Gene

SuperPathways for AGAP11 Gene

No Data Available

Interacting Proteins for AGAP11 Gene

Selected Interacting proteins: Q8TF27-AGA11_HUMAN for AGAP11 Gene via IID

Gene Ontology (GO) - Biological Process for AGAP11 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0043547 positive regulation of GTPase activity IEA --
genes like me logo Genes that share ontologies with AGAP11: view

No data available for Pathways by source and SIGNOR curated interactions for AGAP11 Gene

Drugs & Compounds for AGAP11 Gene

No Compound Related Data Available

Transcripts for AGAP11 Gene

mRNA/cDNA for AGAP11 Gene

(1) REFSEQ mRNAs :
(3) Additional mRNA sequences :
(267) Selected AceView cDNA sequences:
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for AGAP11 Gene

Ankyrin repeat and GTPase domain Arf GTPase activating protein 11:
Representative Sequences:

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for AGAP11 Gene

No ASD Table

Relevant External Links for AGAP11 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for AGAP11 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for AGAP11 Gene

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for AGAP11 Gene

NURSA nuclear receptor signaling pathways regulating expression of AGAP11 Gene:


SOURCE GeneReport for Unigene cluster for AGAP11 Gene:

genes like me logo Genes that share expression patterns with AGAP11: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for AGAP11 Gene

Orthologs for AGAP11 Gene

This gene was present in the common ancestor of human and chimp.

Orthologs for AGAP11 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia CTGLF2 33
  • 97.7 (n)
Species where no ortholog for AGAP11 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • cow (Bos Taurus)
  • dog (Canis familiaris)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • mouse (Mus musculus)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for AGAP11 Gene

Gene Tree for AGAP11 (if available)
Gene Tree for AGAP11 (if available)

Paralogs for AGAP11 Gene

Paralogs for AGAP11 Gene

(17) SIMAP similar genes for AGAP11 Gene using alignment to 2 proteins:

genes like me logo Genes that share paralogs with AGAP11: view

Variants for AGAP11 Gene

Sequence variations from dbSNP and Humsavar for AGAP11 Gene

SNP ID Clin Chr 10 pos Sequence Context AA Info Type
rs1000001811 -- 86,977,609(+) TCTGG(-/A)GTAGC intron-variant
rs1000066683 -- 86,975,806(+) CCCTG(C/G)CTGGG intron-variant
rs1000148963 -- 86,988,746(+) TTGTC(C/T)TTTCT intron-variant
rs1000297753 -- 86,973,712(+) CTGAC(A/G)TTAGG intron-variant
rs1000350462 -- 86,970,264(+) AAAGG(G/T)CTGGT upstream-variant-2KB, splice-donor-variant, utr-variant-5-prime

Structural Variations from Database of Genomic Variants (DGV) for AGAP11 Gene

Variant ID Type Subtype PubMed ID
nsv975708 CNV duplication 23825009
nsv975706 CNV duplication 23825009
nsv974952 CNV duplication 23825009
nsv948111 CNV duplication 23825009
nsv8712 CNV loss 18304495
nsv831939 CNV gain 17160897
nsv517487 CNV gain+loss 19592680
nsv470969 CNV loss 18288195
nsv428236 CNV loss 18775914
nsv1141879 OTHER inversion 24896259
nsv1127130 CNV deletion 24896259
nsv1125508 CNV tandem duplication 24896259
esv2759774 CNV gain+loss 17122850
esv27213 CNV loss 19812545
esv2664328 CNV deletion 23128226

Relevant External Links for AGAP11 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Variation tolerance for AGAP11 Gene

Disorders for AGAP11 Gene

Relevant External Links for AGAP11

Atlas of Genetics and Cytogenetics in Oncology and Haematology:

No disorders were found for AGAP11 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for AGAP11 Gene

Publications for AGAP11 Gene

  1. Prediction of the coding sequences of unidentified human genes. XXII. The complete sequences of 50 new cDNA clones which code for large proteins. (PMID: 11853319) Nagase T … Ohara O (DNA research : an international journal for rapid publication of reports on genes and genomes 2001) 2 3 4 60
  2. Characterization of the Cardiac Overexpression of HSPB2 Reveals Mitochondrial and Myogenic Roles Supported by a Cardiac HspB2 Interactome. (PMID: 26465331) Grose JH … Benjamin IJ (PloS one 2015) 3 60
  3. Insights into RNA biology from an atlas of mammalian mRNA-binding proteins. (PMID: 22658674) Castello A … Hentze MW (Cell 2012) 3 60
  4. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 60
  5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 4 60

Products for AGAP11 Gene

Sources for AGAP11 Gene

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