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AGAP11 Gene

protein-coding   GIFtS: 37
GCID: GC10P088720

Ankyrin Repeat And GTPase Domain Arf GTPase Activating Protein...

  Search for AGAP11
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Ankyrin Repeat And GTPase Domain Arf GTPase Activating Protein 111 2
AGAP-112 3
Arf-GAP With GTPase, ANK Repeat And PH Domain-Containing Protein 112
KIAA19753
Centaurin-Gamma-Like Protein KIAA19753

External Ids:    HGNC: 294211   Entrez Gene: 1193852   Ensembl: ENSG000001513037   UniProtKB: Q8TF273   

Export aliases for AGAP11 gene to outside databases

Previous GC identifer: GC10P082584


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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GeneCards Summary for AGAP11 Gene:
AGAP11 (ankyrin repeat and GTPase domain Arf GTPase activating protein 11) is a protein-coding gene. GO annotations related to this gene include phospholipid binding and ARF GTPase activator activity. An important paralog of this gene is LOC101060581.

UniProtKB/Swiss-Prot: AGA11_HUMAN, Q8TF27
Function: Putative GTPase-activating protein (Potential)




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000010.10  NC_018921.2  NT_030059.14  
Regulatory elements:
   Regulatory transcription factor binding sites in the AGAP11 gene promoter:
         STAT1   AML1a   STAT1beta   STAT1alpha   C/EBPalpha   S8   PPAR-gamma1   HSF2   PPAR-gamma2   
         Other transcription factors

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Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat AGAP11


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 10q23.2   Ensembl cytogenetic band:  10q23.2   HGNC cytogenetic band: 10q23.2

AGAP11 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
AGAP11 gene location

GeneLoc information about chromosome 10         GeneLoc Exon Structure

GeneLoc location for GC10P088720:  view genomic region     (about GC identifiers)

Start:
88,730,498 bp from pter      End:
88,769,960 bp from pter
Size:
39,463 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., and/or eBioscience,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., and/or eBioscience, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: AGA11_HUMAN, Q8TF27 (See protein sequence)
Recommended Name: Arf-GAP with GTPase, ANK repeat and PH domain-containing protein 11  
Size: 550 amino acids; 60549 Da
Sequence caution: Sequence=BAB85561.1; Type=Erroneous initiation;
Secondary accessions: B9EIP7 D3DWE4

Explore the universe of human proteins at neXtProt for AGAP11: NX_Q8TF27

Explore proteomics data for AGAP11 at MOPED


See AGAP11 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

REFSEQ proteins: NP_597704.1  

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(According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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HGNC Gene Families:
ANKRD: Ankyrin repeat domain containing
ArfGAP: ADP-ribosylation factor GTPase activating proteins

5 InterPro protein domains:
 IPR001849 Pleckstrin_homology
 IPR001164 ArfGAP
 IPR011993 PH_like_dom
 IPR002110 Ankyrin_rpt
 IPR020683 Ankyrin_rpt-contain_dom

Graphical View of Domain Structure for InterPro Entry Q8TF27

ProtoNet protein and cluster: Q8TF27

3 Blocks protein domains:
IPB001164 HIV Rev interacting protein signature
IPB001849 Pleckstrin-like
IPB002110 Ankyrin repeat signature


UniProtKB/Swiss-Prot: AGA11_HUMAN, Q8TF27
Similarity: Belongs to the centaurin gamma-like family
Similarity: Contains 2 ANK repeats
Similarity: Contains 1 Arf-GAP domain
Similarity: Contains 1 PH domain


Find genes that share domains with AGAP11           About GenesLikeMe


(According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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Molecular Function:

     UniProtKB/Swiss-Prot Summary: AGA11_HUMAN, Q8TF27
Function: Putative GTPase-activating protein (Potential)

     Gene Ontology (GO): 2 molecular function terms:    About this table

GO IDQualified GO termEvidencePubMed IDs
GO:0008060ARF GTPase activator activity IEA--
GO:0008270zinc ion binding IEA--
     
Find genes that share ontologies with AGAP11           About GenesLikeMe


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(According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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Subcellular locations from COMPARTMENTS: 

CompartmentConfidence
cytosol3
nucleus2
extracellular1
mitochondrion1

(SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for AGAP11
Interactions:

    Search GeneGlobe Interaction Network for AGAP11

Gene Ontology (GO): 1 biological process term:    About this table

GO IDQualified GO termEvidencePubMed IDs
GO:0032312regulation of ARF GTPase activity IEA--

Find genes that share ontologies with AGAP11           About GenesLikeMe



(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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Browse Small Molecules at EMD Millipore
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Browse Tocris compounds for AGAP11 (AGA11)



(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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REFSEQ mRNAs for AGAP11 gene: 
NM_133447.1  

Unigene Cluster for AGAP11:

Ankyrin repeat and GTPase domain Arf GTPase activating protein 11
Hs.511787  [show with all ESTs]
Unigene Representative Sequence: NM_133447
1 Ensembl transcript including schematic representation, and UCSC links where relevant:
ENST00000444431(processed_transcript)
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Additional mRNA sequence: 

AK097165.1 BC062776.1 BC140762.1 

4 DOTS entries:

DT.100058943  DT.100058139  DT.100858878  DT.95194678 

Selected AceView cDNA sequences (see all 267):

BE566379 AW006481 BQ219402 BM748818 BQ218148 H49348 BQ430954 AI434794 
CB107161 AI637713 BG413520 CA434240 BM838642 AJ346418 CR541788 CR541790 
BQ694475 AB075855 CB045310 BU728272 BM693306 NM_006829 AA878084 AA486472 

GeneLoc Exon Structure


(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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AGAP11 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS <intensity>2/3
CGAP TAG: --
AGAP11 Expression
About this image

AGAP11 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

AGAP11 Protein Expression

SOURCE GeneReport for Unigene cluster: Hs.511787
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(Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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This gene was present in the common ancestor of human and chimp.

Orthologs for AGAP11 gene from 1 species (see representative species )    About this table
Organism Taxonomic
classification
Gene Description Human
Similarity
Orthology
Type
Details
chimpanzee
(Pan troglodytes)
Mammalia CTGLF21 ArfGAP with GTPase domain, ankyrin repeat and PH domain more 97.7(n)
95.25(a)
  737901  XM_001141368.3  XP_001141368.3 


ENSEMBL Gene Tree for AGAP11 (if available)
TreeFam Gene Tree for AGAP11 (if available)

(Paralogs according to 1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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Paralogs for AGAP11 gene
LOC101060581  AGAP5  AGAP4  AGAP6  AGAP7  AGAP9  
17 SIMAP similar genes for AGAP11 using alignment to 2 protein entries:     AGA11_HUMAN (see all proteins):
AGAP4    AGAP5    AGAP7    AGAP8    AGAP6    CENTG2
CTGLF11P    AGAP9    AGAP1    AGAP10    FLJ00312    DKFZp761E2216
AGAP3    CENTG3    AGAP2    ARFGAP1    ARFGAP3

Find genes that share paralogs with AGAP11           About GenesLikeMe



(SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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Selected SNPs for AGAP11 (see all 784)    About this table                                 

Genomic DataTranscription Related DataAllele Frequencies
SNP IDValidClinical
significance
Chr 10 posSequence#AA
Chg
TypeMore#Allele
freq
PopTotal
sample
More
----------
rs12403761,2
C,F,A,H--88733150(-) tgcgaT/Ctaaac 1 -- int117Minor allele frequency- C:0.32NS EA NA WA 898
rs12403751,2
C,F,A,H--88733192(-) ggagaA/Gagatt 1 -- int123Minor allele frequency- G:0.34NS EA NA WA 2346
rs127833211,2
C,F,A,H--88733275(+) AGTGCA/GGAGTG 1 -- int116Minor allele frequency- G:0.28NS EA NA WA CSA 792
rs1896670441,2
--88733333(+) ATGTTC/GTTCTG 1 -- int10--------
rs1172904631,2
C,F--88733443(+) TCTGAA/CGGCCA 1 -- int11Minor allele frequency- C:0.03EA 120
rs127716141,2
C,F--88733536(+) attagC/Tcgggt 1 -- int13Minor allele frequency- T:0.50NA 6
rs1117406701,2
C,F--88733596(+) GAATTG/TCTTGA 1 -- int11Minor allele frequency- T:0.50WA 2
rs784722301,2
F--88733731(+) TTCCTA/GAACAA 1 -- int11Minor allele frequency- G:0.01WA 118
rs79132091,2
C--88733748(+) atgatG/Tctaac 1 -- int10--------
rs754600991,2
C,F--88733775(+) GTGGGA/TACAGT 1 -- int12Minor allele frequency- T:0.04WA 120

HapMap Linkage Disequilibrium report for AGAP11 (88730498 - 88769960 bp)

Structural Variations
     Database of Genomic Variants (DGV) Selected variations for AGAP11 (see all 15):    About this table    
Variant IDTypeSubtypePubMed ID
esv2664328CNV Deletion23128226
dgv797n71CNV Loss21882294
nsv428236CNV Loss18775914
nsv895858CNV Loss21882294
esv27213CNV Loss19812545
nsv8712CNV Loss18304495
nsv470969CNV Loss18288195
nsv831939CNV Gain17160897
nsv517487CNV Gain+Loss19592680
essv23924CNV CNV17122850

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(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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  --

(in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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PubMed articles for AGAP11 gene integrated from 10 sources:
(articles sorted by number of sources associating them with AGAP11)
    Utopia: connect your pdf to the dynamic
world of online information

  1. Prediction of the coding sequences of unidentified human genes. XXII. The complete sequences of 50 new cDNA clones which code for large proteins. (PubMed id 11853319)1, 2, 3 Nagase T.... Ohara O. (DNA Res. 2001)
  2. A germline-specific class of small RNAs binds mammalian Piwi proteins. (PubMed id 16751776)1 Girard A....Carmell M.A. (Nature 2006)
  3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)2 Gerhard D.S.... Malek J. (Genome Res. 2004)
  4. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1 Ota T.... Sugano S. (Nat. Genet. 2004)
  5. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002)

(in PubMed, OMIM, and NCBI Bookshelf)
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 ANDOR
Aliases
Free Text  

  Query String
PubMed
OMIM
NCBI Bookshelf
  (Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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Entrez Gene: 119385 HGNC: 29421 AceView: SNCGandC10orf116andKIAA1975 Ensembl:ENSG00000151303 euGenes: HUgn119385
ECgene: AGAP11 H-InvDB: AGAP11

(According to HUGE)
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HUGE: KIAA1975

(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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NameDescription
PharmGKB entry for AGAP11 Pharmacogenomics, SNPs, Pathways

(Patent information from GeneIP,
Licensable technologies from WIS Yeda, Salk, Tufts,
IP news from LifeMap Sciences, Inc.)
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Patent Information for AGAP11 gene:
Search GeneIP for patents involving AGAP11

GeneCards and IP:
Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, eBioscience, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
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 Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat AGAP11
 inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for AGAP11
 inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for AGAP11
 LSBio Antibodies in human, mouse, rat for AGAP11
Customized transgenic rodents for:
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GeneCards Homepage - Last full update: 7 May 2014 - Incrementals: 9 May 2014 , 2 Jun 2014 , 26 Jun 2014 , 30 Jun 2014 , 21 Aug 2014 , 8 Sep 2014

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