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AGAP10 Gene

protein-coding   GIFtS: 25
GCID: GC10M047191          (predicted)

ArfGAP With GTPase Domain, Ankyrin Repeat And PH Domain...

(Previous names: centaurin, gamma-like family, member 7)
(Previous symbol: CTGLF7)
  Search for AGAP10
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
ArfGAP With GTPase Domain, Ankyrin Repeat And PH Domain 101 2
CTGLF71 2 3
Centaurin, Gamma-Like Family, Member 71 2
bA144G6.22
AGAP-103
Centaurin-Gamma-Like Family Member 73

External Ids:    HGNC: 234621   Entrez Gene: 7281272   Ensembl: ENSG000002041727   UniProtKB: Q5T2P93   

Export aliases for AGAP10 gene to outside databases

Previous GC identifer: GC10M046615


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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GeneCards Summary for AGAP10 Gene:
AGAP10 (ArfGAP with GTPase domain, ankyrin repeat and PH domain 10) is a protein-coding gene. GO annotations related to this gene include phospholipid binding and ARF GTPase activator activity. An important paralog of this gene is AGAP5.

UniProtKB/Swiss-Prot: AGA10_HUMAN, Q5T2P9
Function: Putative GTPase-activating protein (Potential)




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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Regulatory elements:
   Regulatory transcription factor binding sites in the AGAP10 gene promoter:
         Sox5   AML1a   FOXL1   Egr-4   CREB   HFH-1   FOXJ2 (long isoform)   deltaCREB   FOXJ2   Pax-4a   
         Other transcription factors

Browse SwitchGear Promoter luciferase reporter plasmids
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Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat AGAP10


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 10q11.22   Ensembl cytogenetic band:  10q11.22   HGNC cytogenetic band: 10q11.22

AGAP10 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
AGAP10 gene location

GeneLoc information about chromosome 10         GeneLoc Exon Structure

GeneLoc location for GC10M047191:  view genomic region     (about GC identifiers)

Start:
47,190,590 bp from pter      End:
47,239,738 bp from pter
Size:
49,149 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: AGA10_HUMAN, Q5T2P9 (See protein sequence)
Recommended Name: Arf-GAP with GTPase, ANK repeat and PH domain-containing protein 10  
Size: 658 amino acids; 72707 Da
Miscellaneous: Encoded by one of the numerous copies of centaurin gamma-like genes clustered in the q11 region of
chromosome 10
Sequence caution: Sequence=CAI12206.1; Type=Erroneous gene model prediction;

Explore the universe of human proteins at neXtProt for AGAP10: NX_Q5T2P9

Explore proteomics data for AGAP10 at MOPED


See AGAP10 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB


ENSEMBL proteins: 
 ENSP00000392206   ENSP00000407436   ENSP00000347372  

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(According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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HGNC Gene Families:
PLEKH: Pleckstrin homology (PH) domain containing
ANKRD: Ankyrin repeat domain containing
ArfGAP: ADP-ribosylation factor GTPase activating proteins

4 InterPro protein domains:
 IPR001849 Pleckstrin_homology
 IPR001164 ArfGAP
 IPR011993 PH_like_dom
 IPR020683 Ankyrin_rpt-contain_dom

Graphical View of Domain Structure for InterPro Entry Q5T2P9

ProtoNet protein and cluster: Q5T2P9

UniProtKB/Swiss-Prot: AGA10_HUMAN, Q5T2P9
Similarity: Belongs to the centaurin gamma-like family
Similarity: Contains 1 ANK repeat
Similarity: Contains 1 Arf-GAP domain
Similarity: Contains 1 PH domain


AGAP10 for domains           About GeneDecksing


(According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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Molecular Function:

     UniProtKB/Swiss-Prot Summary: AGA10_HUMAN, Q5T2P9
Function: Putative GTPase-activating protein (Potential)

     Gene Ontology (GO): 4 molecular function terms:    About this table

GO IDQualified GO termEvidencePubMed IDs
GO:0003924GTPase activity ----
GO:0005525GTP binding ----
GO:0008060ARF GTPase activator activity IEA--
GO:0008270zinc ion binding IEA--
     
AGAP10 for ontologies           About GeneDecksing


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(According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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Subcellular locations from COMPARTMENTS: 

CompartmentConfidence
cytosol2

(SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for AGAP10
Interactions:

    Search GeneGlobe Interaction Network for AGAP10

STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

Selected Interacting proteins for AGAP10 (ENSP000004074364) via UniProtKB, MINT, STRING, and/or I2D (see all 67)
InteractantInteraction Details
GeneCardExternal ID(s)
AATFENSP000002254024STRING: ENSP00000225402
BYSLENSP000002303404STRING: ENSP00000230340
HEATR1ENSP000003555414STRING: ENSP00000355541
NOC4LENSP000003288544STRING: ENSP00000328854
NOL10ENSP000003711014STRING: ENSP00000371101
About this table

Gene Ontology (GO): 1 biological process term:    About this table

GO IDQualified GO termEvidencePubMed IDs
GO:0032312regulation of ARF GTPase activity IEA--

AGAP10 for ontologies           About GeneDecksing



(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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Browse Small Molecules at EMD Millipore
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Browse Tocris compounds for AGAP10 (AGA10)



(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
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3 Ensembl transcripts including schematic representations, and UCSC links where relevant:
ENST00000452145(uc009xnf.2) ENST00000413193(uc001jei.3) ENST00000355232

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GeneLoc Exon Structure


(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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AGAP10 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS <intensity>2/3
CGAP TAG: --
AGAP10 Expression
About this image

AGAP10 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

AGAP10 Protein Expression
    Custom PCR Arrays for AGAP10
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(Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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This gene was present in the common ancestor of animals.

Orthologs for AGAP10 gene from Selected species (see all 9)    About this table
Organism Taxonomic
classification
Gene Description Human
Similarity
Orthology
Type
Details
oppossum
(Monodelphis domestica)
Mammalia --
Uncharacterized protein
58(a)
1 → many
2(536230123-536278792)
chicken
(Gallus gallus)
Aves --
Uncharacterized protein
50(a)
1 → many
7(5139160-5321453)
lizard
(Anolis carolinensis)
Reptilia --
--
Uncharacterized protein
8(a)
56(a)
many ↔ many
many ↔ many
1(119461547-119529618)
1(119629499-119789786)
zebrafish
(Danio rerio)
Actinopterygii agap16
ArfGAP with GTPase domain, ankyrin repeat and PH d...
42(a)
1 → many
6(15964316-16312330) ENSDARG00000062123
fruit fly
(Drosophila melanogaster)
Insecta cenG1A6
centaurin gamma 1A
23(a)
1 → many
2L(13835567-13898715)
worm
(Caenorhabditis elegans)
Secernentea cnt-26
Protein CNT-2, isoform b
18(a)
1 → many
III(10655770-10677522) WBGene00000566


ENSEMBL Gene Tree for AGAP10 (if available)
TreeFam Gene Tree for AGAP10 (if available)

(Paralogs according to 1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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Paralogs for AGAP10 gene
AGAP52  AGAP62  ASAP12  ARAP32  ACAP22  ACAP32  ASAP22  ARAP12  
AGAP32  ARAP22  AGAP22  AGAP42  AGAP12  AGAP82  ACAP12  AGAP72  
AGAP92  ASAP32  
18 SIMAP similar genes for AGAP10 using alignment to 3 protein entries:     AGA10_HUMAN (see all proteins):
AGAP4    FLJ00312    AGAP5    AGAP8    AGAP6    AGAP7
AGAP11    CTGLF11P    AGAP9    CENTG2    AGAP1    DKFZp761E2216
AGAP3    AGAP2    ARFGAP1    CCNYL2    CENTG3    ARFGAP3

AGAP10 for paralogs           About GeneDecksing


5 Pseudogenes.org Pseudogenes for AGAP10
PGOHUM00000238451 PGOHUM00000238480 PGOHUM00000238531 PGOHUM00000262856 PGOHUM00000238792


(SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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Selected SNPs for AGAP10 (see all 14)    About this table    
Genomic DataTranscription Related DataAllele Frequencies
SNP IDValidClinical
significance
Chr 10 posSequence#AA
Chg
TypeMore#Allele
freq
PopTotal
sample
More
----------
rs2001010341,2
F--47207779(+) AAACTA/GTCAAT 1 -- int11Minor allele frequency- G:0.02EU 227
rs2020143611,2
C,F--47207813(+) TTACAT/CGGTTT 2 /H /R mis11Minor allele frequency- C:0.01EU 407
rs1859416631,2
--47207862(+) AAAAAA/TAAAAA 1 -- int10--------
rs3703722801,2
C--47208108(+) AAGGGC/TAAAAA 2 -- int10--------
rs3702399311,2
----47207937(+) CTATGA/TAAATG 2 -- int10--------
rs2016334321,2
----47211463(+) CTCTTC/TAAAAA 1 -- int10--------
rs3733434841,2
----47208147(+) TAAAAA/CTTTAA 2 -- int10--------
rs2010217061,2
----47207780(+) AACTAT/CCAATT 1 -- int11Minor allele frequency- C:0.00EU 463
rs3765440141,2
----47207637(+) GCTAAA/GTAAAC 2 -- int10--------
rs3759828611,2
----47208037(+) CTTAGA/TTTTCA 2 -- int10--------

HapMap Linkage Disequilibrium report for AGAP10 (47190590 - 47239738 bp)

Structural Variations
      Database of Genomic Variants (DGV) variations for AGAP10: --
Site Specific Mutation Identification with PCR Assays
Search QIAGEN SeqTarget long-range PCR primers for resequencing AGAP10
DNA2.0 Custom Variant and Variant Library Synthesis for AGAP10

(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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  --

(in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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PubMed article for AGAP10 gene integrated from 10 sources:
(articles sorted by number of sources associating them with AGAP10)
    Utopia: connect your pdf to the dynamic
world of online information

  1. The DNA sequence and comparative analysis of human chromosome 10. (PubMed id 15164054)2 Deloukas P.... Rogers J. (Nature 2004)

(in PubMed, OMIM, and NCBI Bookshelf)
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 ANDOR
Aliases
Free Text  

  Query String
PubMed
OMIM
NCBI Bookshelf
  (Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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Entrez Gene: 728127 HGNC: 23462 Ensembl:ENSG00000204172 euGenes: HUgn728127 ECgene: AGAP10
H-InvDB: AGAP10

(According to HUGE)
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  --

(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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NameDescription
PharmGKB entry for AGAP10 Pharmacogenomics, SNPs, Pathways

(Patent information from GeneIP,
Licensable technologies from WIS Yeda, Salk, Tufts,
IP news from LifeMap Sciences, Inc.)
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Patent Information for AGAP10 gene:
Search GeneIP for patents involving AGAP10

GeneCards and IP:
Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript, and ESI BIO, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
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GeneCards Homepage - Last full update: 7 May 2014 - Incrementals: 9 May 2014 , 2 Jun 2014 , 26 Jun 2014 , 30 Jun 2014

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The GeneCards human gene database gene index: 1 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z 


Developed at the Crown Human Genome Center, Department of Molecular Genetics, the Weizmann Institute of Science

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