AGAP10 Gene
protein-coding GIFtS: 28
GCID: GC10M047191 (predicted)
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ArfGAP with GTPase domain, ankyrin repeat and PH domain...(Previous names: centaurin, gamma-like family, member 7 )
(Previous symbol: CTGLF7)
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Aliases
for AGAP10 gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
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| Aliases |
|---|
| ArfGAP With GTPase Domain, Ankyrin Repeat And PH Domain 101 2 | | CTGLF71 2 3 | | BA144G6.21 | | Centaurin, Gamma-Like Family, Member 71 2 | | AGAP-103 | | Centaurin-Gamma-Like Family Member 73 |
Export aliases for AGAP10 gene to outside databasesPrevious GC identifer: GC10M046615 |
Summaries
for AGAP10 gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
UniProtKB/Swiss-Prot: AGA10_HUMAN, Q5T2P9Function: Putative GTPase-activating protein (Potential)
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Genomic Views
for AGAP10 gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the AGAP10 gene promoter:
Sox5 AML1a FOXL1 Egr-4 CREB HFH-1 FOXJ2 (long isoform) deltaCREB FOXJ2 Pax-4a
Other transcription factors
Search SABiosciences Chromatin IP Primers for AGAP10
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat AGAP10 |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 10q11.22 Ensembl cytogenetic band: 10q11.22 HGNC cytogenetic band: 10q11.22AGAP10 Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 10 GeneLoc Exon Structure GeneLoc location for GC10M047191: view genomic region
(about GC identifiers)
Start:
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47,190,590 bp from pter |
End:
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47,239,738 bp from pter |
Size:
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49,149 bases |
Orientation:
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minus strand |
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Proteins
for AGAP10 gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
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UniProtKB/Swiss-Prot: AGA10_HUMAN, Q5T2P9 (See
protein sequence)Recommended Name: Arf-GAP with GTPase, ANK repeat and PH domain-containing protein 10 Size: 658 amino acids; 72707 Da
Miscellaneous: Encoded by one of the numerous copies of centaurin gamma-like genes clustered in the q11 region ofchromosome 10
Sequence caution: Sequence=CAI12206.1; Type=Erroneous gene model prediction;Explore the universe of human proteins at neXtProt for AGAP10: NX_Q5T2P9
Post-translational modifications:
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_Q5T2P9
AGAP10 Protein expression data from MOPED and PaxDb: About this image 
ENSEMBL proteins: ENSP00000392206 ENSP00000407436 ENSP00000347372
Human Recombinant Protein Products:
AGAP10 Antibody Products:
Assay Products for AGAP10: |
Protein
Domains /
Families
for AGAP10 gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
AGAP10 for domains About GeneDecksing
4 InterPro domains/families:Graphical View of Domain Structure for InterPro Entry Q5T2P9ProtoNet protein and cluster: Q5T2P9 UniProtKB/Swiss-Prot: AGA10_HUMAN, Q5T2P9Similarity: Belongs to the centaurin gamma-like familySimilarity: Contains 1 ANK repeatSimilarity: Contains 1 Arf-GAP domainSimilarity: Contains 1 PH domain |
Function
for AGAP10 gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
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Function Summary:
UniProtKB/Swiss-Prot: AGA10_HUMAN, Q5T2P9Function: Putative GTPase-activating protein (Potential)
Gene Ontology (GO): 5 molecular function terms (GO ID links to tree view): About this table
AGAP10 for ontologies About GeneDecksing
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Pathways & Interactions
for AGAP10 gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
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Interactions:
Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for AGAP10
Gene Ontology (GO): 1 biological process term (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
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| GO:0032312 | regulation of ARF GTPase activity |
IEA | -- |
AGAP10 for ontologies About GeneDecksing
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Drugs & Compounds
for AGAP10 gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
 Browse Tocris compounds for AGAP10
Search CenterWatch for drugs/clinical trials and news about AGAP10 / AGA10 
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Transcripts
for AGAP10 gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
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3 Ensembl transcripts including schematic representations, and UCSC links where relevant: ENST00000452145(uc009xnf.2) ENST00000413193(uc001jei.3) ENST00000355232
GeneLoc Exon Structure
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Expression
for AGAP10 gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| AGAP10 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: --
About this image
See AGAP10 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for AGAP10
SABiosciences Custom PCR Arrays for AGAP10
Primer
Products: |  | Browse OriGene genome-wide validated SYBR primer pairs
Browse OriGene validated miRNA SYBR primer pairs
| | | SABiosciences RT2 qPCR Primer Assay in human, mouse / rat AGAP10 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat AGAP10 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat AGAP10 |
Orthologs
for AGAP10 gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
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This gene was present in the common ancestor of animals.
Orthologs for AGAP10 gene from 4/17 species (see all 17) About this table
ENSEMBL Gene Tree for AGAP10 (if available)
TreeFam Gene Tree for AGAP10 (if available) |
Paralogs
for AGAP10 gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| Paralogs for AGAP10 gene
- AGAP91 2 AGAP81 2 AGAP41 2 AGAP51 2 AGAP71 2 AGAP61 2 AGAP11 ASAP12
- ACAP22 ARAP32 GIT22 ACAP32 ARAP12 ASAP22 AGAP32 GIT12
- ARAP22 AGAP22 AGAP12 ACAP12 ASAP32
18 SIMAP similar genes for AGAP10 using alignment to 3 protein entries: AGA10_HUMAN (see all proteins):AGAP4 FLJ00312 AGAP5 AGAP8 AGAP6 AGAP7
AGAP11 CTGLF11P AGAP9 CENTG2 AGAP1 DKFZp761E2216
AGAP3 AGAP2 CENTG3 ARFGAP1 CCNYL2 ARFGAP3
AGAP10 for paralogs About GeneDecksing
5 Pseudogenes.org Pseudogenes for AGAP10
PGOHUM00000238451 PGOHUM00000238480 PGOHUM00000238531 PGOHUM00000262856 PGOHUM00000238792
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Genomic Variants
for AGAP10 gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
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| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr 10 pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
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HapMap Linkage Disequilibrium report for AGAP10 (47190590 - 47239738 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV) variations for AGAP10: -- | SABiosciences Cancer Mutation PCR Assays |
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Disorders
/ Diseases
for AGAP10 gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
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AGAP10 for disorders About GeneDecksing
1  disease for AGAP10: About MalaCardsmalaria
Export disorders for AGAP10 gene to outside databases
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Publications
for AGAP10 gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
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PubMed article for AGAP10 gene integrated from 9 sources:
(articles sorted by number of sources associating them with AGAP10) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- The DNA sequence and comparative analysis of human chromosome 10. (PubMed id 15164054)2 Deloukas P.... Rogers J. (2004)
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External Searches for AGAP10 gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
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Genome Databases showing AGAP10 gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
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Other Databases showing AGAP10 gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing AGAP10 gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
| Name | Description |
| PharmGKB entry for AGAP10 | Pharmacogenomics, SNPs, Pathways |
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About This Section
| Patent Information for AGAP10 gene:
Search GeneIP for patents involving AGAP10
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for AGAP10 gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences),
In Situ Hybridization Assays from
Advanced Cell Diagnostics
About This Section
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|  | QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat AGAP10 | | | Search QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing AGAP10 | | | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat AGAP10 | | | QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat AGAP10 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat AGAP10 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat AGAP10 |
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| | | | Search Tocris compounds for AGAP10 |
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 | | | AGAP10 Proteins, Antibodies, CLIAs, and ELISAs |
| | | |  |  |  | | | | Search ThermoFisher Antibodies for AGAP10 |
| | | Search Vector BioLabs for ready-to-use adenovirus/AAV for human, mouse, rat AGAP10 |
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