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AFTPH Gene

protein-coding   GIFtS: 50
GCID: GC02P064751

Aftiphilin

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(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
aftiphilin1 2
Nbla103882
Aftiphilin Protein2
AFTH3

External Ids:    HGNC: 259511   Entrez Gene: 548122   Ensembl: ENSG000001198447   UniProtKB: Q6ULP23   

Export aliases for AFTPH gene to outside databases

Previous GC identifers: GC02P064604 GC02P064485


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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GeneCards Summary for AFTPH Gene:
AFTPH (aftiphilin) is a protein-coding gene. GO annotations related to this gene include clathrin binding.

UniProtKB/Swiss-Prot: AFTIN_HUMAN, Q6ULP2
Function: May play a role in membrane trafficking

Gene Wiki entry for AFTPH Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000002.11  NT_022184.16  NC_018913.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the AFTPH gene promoter:
         AP-1   ATF-2   E2F-2   c-Jun   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidAFTPH promoter sequence
   Search Chromatin IP Primers for AFTPH

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat AFTPH


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 2p14   Ensembl cytogenetic band:  2p14   HGNC cytogenetic band: 2p14

AFTPH Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
AFTPH gene location

GeneLoc information about chromosome 2         GeneLoc Exon Structure

GeneLoc location for GC02P064751:  view genomic region     (about GC identifiers)

Start:
64,751,439 bp from pter      End:
64,820,139 bp from pter
Size:
68,701 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., and/or eBioscience,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., and/or eBioscience, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: AFTIN_HUMAN, Q6ULP2 (See protein sequence)
Recommended Name: Aftiphilin  
Size: 937 amino acids; 102200 Da
Subunit: Interacts with GGA1, GGA3, AP1G1 and AP1G2 via their GAE domain
Sequence caution: Sequence=AAH22247.1; Type=Frameshift; Positions=919; Sequence=BAB13930.1; Type=Erroneous
initiation; Sequence=BAB14949.1; Type=Erroneous initiation;
Secondary accessions: D6W5E9 Q6ZM66 Q86VW3 Q8TCF3 Q9H7E3 Q9HAB9 Q9NXS4
Alternative splicing: 5 isoforms:  Q6ULP2-1   Q6ULP2-2   Q6ULP2-3   Q6ULP2-4   Q6ULP2-5   (May be due to intron retention. No experimental confirmation available)

Explore the universe of human proteins at neXtProt for AFTPH: NX_Q6ULP2

Explore proteomics data for AFTPH at MOPED

Post-translational modifications: 

  • Modification sites at neXtProt
  • Modification sites at PhosphoSitePlus

  • See AFTPH Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (3 alternative transcripts): 
    NP_001002243.1  NP_060127.3  NP_982261.2  

    ENSEMBL proteins: 
     ENSP00000238856   ENSP00000387071   ENSP00000386913   ENSP00000397726   ENSP00000238855  

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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    ProtoNet protein and cluster: Q6ULP2

    UniProtKB/Swiss-Prot: AFTIN_HUMAN, Q6ULP2
    Domain: The WXXF motifs mediate binding of accessory proteins to the ear-domain of AP-1, GGAs and AP-2 through
    hydrophobic interactions. Selective binding to the GAE domains of AP-1 or to the alpha-ear domain of AP-2 is
    tuned by the acidic context surrounding the motif and the properties of the second residue of the motif itself
    (By similarity)


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: AFTIN_HUMAN, Q6ULP2
    Function: May play a role in membrane trafficking

         Gene Ontology (GO): 1 molecular function term:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0030276clathrin binding IDA15758025
         
    Find genes that share ontologies with AFTPH           About GenesLikeMe


    Animal Models:
       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for AFTPH
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    miRNA
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    miRTarBase miRNAs that target AFTPH:
    hsa-mir-374b-5p (MIRT016058), hsa-mir-181a-5p (MIRT025206), hsa-mir-21-5p (MIRT031032)

    Block miRNA regulation of human, mouse, rat AFTPH using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate AFTPH (see all 39):
    hsa-miR-411* hsa-miR-140-5p hsa-miR-323-3p hsa-miR-379* hsa-miR-1197 hsa-miR-3653 hsa-miR-1273d hsa-miR-133a
    SwitchGear 3'UTR luciferase reporter plasmidAFTPH 3' UTR sequence
    Inhib. RNA
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    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    AFTIN_HUMAN, Q6ULP2: Cytoplasm. Note=Colocalizes with AP1G1 and clathrin
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    cytosol5
    golgi apparatus5
    nucleus4

    Gene Ontology (GO): Selected cellular component terms (see all 6):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus ----
    GO:0005737cytoplasm ----
    GO:0005794Golgi apparatus ----
    GO:0005829cytosol IDA15758025
    GO:0030121AP-1 adaptor complex IDA15758025

    Find genes that share ontologies with AFTPH           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for AFTPH
    Interactions:

        GeneGlobe Interaction Network for AFTPH

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for AFTPH (Q6ULP22, 3 ENSP000002388554) via UniProtKB, MINT, STRING, and/or I2D (see all 64)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    UBE3AQ050862, 3, ENSP000003810454MINT-8276354 I2D: score=2 STRING: ENSP00000381045
    GGA1Q9UJY53, ENSP000003413444I2D: score=1 STRING: ENSP00000341344
    AP1G1O437473, ENSP000003771484I2D: score=1 STRING: ENSP00000377148
    GGA2Q9UJY43, ENSP000003119624I2D: score=1 STRING: ENSP00000311962
    GGA3Q9NZ523, ENSP000002455414I2D: score=1 STRING: ENSP00000245541
    About this table

    Gene Ontology (GO): 1 biological process term:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0015031protein transport IEA--

    Find genes that share ontologies with AFTPH           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for AFTPH (AFTIN)



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for AFTPH gene (3 alternative transcripts): 
    NM_001002243.2  NM_017657.4  NM_203437.3  

    Unigene Cluster for AFTPH:

    Aftiphilin
    Hs.655167  [show with all ESTs]
    Unigene Representative Sequence: AL833962
    7 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000238856(uc002sda.3 uc002sdb.3) ENST00000498706 ENST00000409933
    ENST00000409183 ENST00000487769 ENST00000422803(uc002sdc.3) ENST00000238855(uc002scz.3)

    miRNA
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    Block miRNA regulation of human, mouse, rat AFTPH using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate AFTPH (see all 39):
    hsa-miR-411* hsa-miR-140-5p hsa-miR-323-3p hsa-miR-379* hsa-miR-1197 hsa-miR-3653 hsa-miR-1273d hsa-miR-133a
    SwitchGear 3'UTR luciferase reporter plasmidAFTPH 3' UTR sequence
    Inhib. RNA
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    Predesigned siRNA for gene silencing in human, mouse, rat AFTPH
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    GenScript: all cDNA clones in your preferred vector (see all 3): AFTPH (NM_001002243)
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    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat AFTPH
    Primer
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    OriGene qPCR primer pairs and template standards for AFTPH
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    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat AFTPH
      QuantiTect SYBR Green Assays in human, mouse, rat AFTPH
      QuantiFast Probe-based Assays in human, mouse, rat AFTPH

    Additional mRNA sequence: 

    AB073356.1 AK000087.1 AK021899.1 AK024658.1 AK222821.1 AL833962.2 AY367088.1 BC022247.1 
    BC047529.1 

    13 DOTS entries:

    DT.422833  DT.100825726  DT.100825717  DT.446217  DT.101957094  DT.100825718  DT.218404  DT.91768438 
    DT.218405  DT.86843088  DT.91768439  DT.95293010  DT.95102278 

    Selected AceView cDNA sequences (see all 291):

    AI254347 CA444731 AI567913 AA890197 AA470446 CK823389 T33352 AA583062 
    BE895955 AI383780 BC047529 BM668634 AL833962 AI128320 CA405426 T30703 
    AA703242 Z44609 T32973 AI080442 AL708627 AI247225 AA236020 BP428706 

    GeneLoc Exon Structure

    Selected Alternative Splicing Database (ASD) splice patterns (SP) for AFTPH (see all 6)    About this scheme

    ExUns: 1a · 1b · 1c ^ 2 ^ 3 ^ 4a · 4b · 4c ^ 5a · 5b ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11 ^ 12 ^ 13 ^ 14
    SP1:                                                                                                                  
    SP2:                                                                                                                  
    SP3:                                                                                                                  
    SP4:              -                                                                                                   
    SP5:                                                                                                                  


    ECgene alternative splicing isoforms for AFTPH

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    AFTPH expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: CCCAAGGTCT
    AFTPH Expression
    About this image


    AFTPH expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 2) fully expand
     
     Blood (Cardiovascular System)
             Definitive Hematopoietic Stem Cells Definitive Yolk Sac
     
     Yolk Sac (Extraembryonic Tissues)
             Definitive Hematopoietic Stem Cells Definitive Yolk Sac
    AFTPH Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    AFTPH Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.655167
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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for AFTPH

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of animals.

    Orthologs for AFTPH gene from Selected species (see all 14)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Aftph1 , 5 aftiphilin1, 5 85.25(n)1
    79.05(a)1
      11 (13.25 cM)5
    2165491  NM_181411.31  NP_852076.11 
     206850845 
    chicken
    (Gallus gallus)
    Aves AFTPH1 aftiphilin 72.23(n)
    62.83(a)
      421277  XM_419346.3  XP_419346.2 
    lizard
    (Anolis carolinensis)
    Reptilia AFTPH6
    aftiphilin
    52(a)
    1 ↔ 1
    1(124047508-124091704)
    African clawed frog
    (Xenopus laevis)
    Amphibia Xl.331722 Xenopus laevis transcribed sequence with moderate similarity to protein refNP_060127.1 (H.sapiens) hypothetical protein FLJ20080 [Homo sapiens] less 83.21(n)    BJ088328.1 
    zebrafish
    (Danio rerio)
    Actinopterygii aftpha1 aftiphilin a 51.92(n)
    46.51(a)
      556043  NM_001145561.1  NP_001139033.1 
    worm
    (Caenorhabditis elegans)
    Secernentea Y45G5AM.96
    Protein Y45G5AM.9, isoform b
    26(a)
    1 ↔ 1
    V(4181332-4191515) WBGene00021561


    ENSEMBL Gene Tree for AFTPH (if available)
    TreeFam Gene Tree for AFTPH (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for AFTPH gene
    1 SIMAP similar gene for AFTPH using alignment to 2 protein entries:     AFTIN_HUMAN (see all proteins):
    Nbla10388

    Find genes that share paralogs with AFTPH           About GenesLikeMe



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for AFTPH (see all 1450)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 2 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1885848991,2
    --64749440(+) GCTTAC/TAACAC 3 -- us2k10--------
    rs1423883231,2
    --64749452(+) AAAGGG/TACACA 3 -- us2k10--------
    rs1811736351,2
    --64749459(+) CACAAA/CATCTA 3 -- us2k10--------
    rs2019292841,2
    C--64749504(+) CACAG-/AAAAAA 3 -- us2k10--------
    rs1861454551,2
    --64749509(+) GAAAAA/CAAAAC 3 -- us2k10--------
    rs67522601,2
    C,F,A,H--64749583(+) CTTAGA/GTAATG 3 -- us2k124Minor allele frequency- G:0.48NS EA NA WA 1236
    rs1906213791,2
    --64749595(+) AGTTAC/TGGCCA 3 -- us2k10--------
    rs1840624731,2
    C--64749692(+) AAACAC/TTCAAA 3 -- us2k10--------
    rs1513006991,2
    --64749738(+) GGGCAC/TTGTCT 3 -- us2k10--------
    rs1404764171,2
    --64749747(+) CTTCGG/TAATTA 3 -- us2k10--------

    HapMap Linkage Disequilibrium report for AFTPH (64751439 - 64820139 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 6 variations for AFTPH:    About this table    
    Variant IDTypeSubtypePubMed ID
    esv269614CNV Insertion20981092
    nsv2754CNV Insertion18451855
    nsv820060CNV Loss19587683
    nsv2756CNV Loss18451855
    nsv834245CNV Gain17160897
    nsv7313OTHER Inversion18451855

    Site Specific Mutation Identification with PCR Assays
    Search QIAGEN SeqTarget long-range PCR primers for resequencing AFTPH
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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    Find genes that share disorders with AFTPH           About GenesLikeMe

    Genetic Association Database (GAD): AFTPH

    Export disorders for AFTPH gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for AFTPH gene, integrated from 10 sources (see all 24):
    (articles sorted by number of sources associating them with AFTPH)
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    1. Definition of the consensus motif recognized by gamma-adaptin ear domains. (PubMed id 14665628)1, 2, 3, 9 Mattera R.... Bonifacino J.S. (J. Biol. Chem. 2004)
    2. Aftiphilin is a component of the clathrin machinery in neurons. (PubMed id 15811338)1, 3, 9 Burman J.L....McPherson P.S. (FEBS Lett. 2005)
    3. The aftiphilin/p200/gamma-synergin complex. (PubMed id 15758025)1, 3, 9 Hirst J....Robinson M.S. (Mol. Biol. Cell 2005)
    4. A probability-based approach for high-throughput protein phosphorylation analysis and site localization. (PubMed id 16964243)1, 2 Beausoleil S.A.... Gygi S.P. (Nat. Biotechnol. 2006)
    5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    6. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (Nat. Genet. 2004)
    7. Aftiphilin and gamma-synergin are required for secretagogue sensitivity of Weibel-Palade bodies in endothelial cells. (PubMed id 18815278)1, 9 Lui-Roberts W.W....Cutler D.F. (Mol. Biol. Cell 2008)
    8. Pathway Analysis of ChIP-Seq-Based NRF1 Target Genes Suggests a Logical Hypothesis of their Involvement in the Pathogenesis of Neurodegenerative Diseases. (PubMed id 24250222)1 Satoh J....Yamamoto Y. (Gene Regul Syst Bio 2013)
    9. Charting the landscape of tandem BRCT domain-mediated protein interactions. (PubMed id 22990118)1 Woods N.T....Monteiro A.N. (Sci Signal 2012)
    10. Systems-wide analysis of ubiquitylation dynamics reveals a key role for PAF15 ubiquitylation in DNA-damage bypass. (PubMed id 23000965)1 Povlsen L.K....Choudhary C. (Nat. Cell Biol. 2012)

    (in PubMed, OMIM, and NCBI Bookshelf)
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    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 54812 HGNC: 25951 AceView: AFTIPHILIN Ensembl:ENSG00000119844 euGenes: HUgn54812
    ECgene: AFTPH H-InvDB: AFTPH

    (According to HUGE)
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    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for AFTPH Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for AFTPH gene:
    Search GeneIP for patents involving AFTPH

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, eBioscience, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
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