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Aliases & Descriptions for AFP
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc
, and/or 7Ensembl,
8miRBase) About This Section
|
| Aliases |
|---|
| Alpha-1-fetoprotein 3 | | Alpha-fetoglobulin 3 | | FETA 1, 2 | | HP 5 | | HPAFP 2, 3 | | OTTHUMP00000160480 2 | | alpha-1-fetoprotein 2 | | alpha-fetoglobulin 2 | | alpha-fetoprotein 2 |
| | |
| | Search outside databases for aliases for AFP genePrevious GC identifers: GC04P074291 GC04P074703 GC04P074768 GC04P074666 |
Summaries for AFP(According to Entrez Gene,
Wikipedia's
Gene Wiki,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
| EntrezGene summary for AFP: This gene encodes alpha-fetoprotein, a major plasma protein produced by the yolk sac and the liver during fetal life. Alpha-fetoprotein expression in adults is often associated with hepatoma or teratoma. However, hereditary persistance of alpha-fetoprotein may also be found in individuals with no obvious pathology. The protein is thought to be the fetal counterpart of serum albumin, and the alpha-fetoprotein and albumin genes are present in tandem in the same transcriptional orientation on chromosome 4. Alpha-fetoprotein is found in monomeric as well as dimeric and trimeric forms, and binds copper, nickel, fatty acids and bilirubin. The level of alpha-fetoprotein in amniotic fluid is used to measure renal loss of protein to screen for spina bifida and anencephaly. [provided by RefSeq] UniProtKB/Swiss-Prot: FETA_HUMAN, P02771Function: Binds copper, nickel, and fatty acids as well as, and bilirubin less well than, serum albumin. Only a small percentage (less than 2%) of the human AFP shows estrogen-binding propertiesGene Wiki entry for AFP (Alpha-fetoprotein) |
Genomic Location for AFP
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 36),
and/or miRBase,
Genomic Views according to
UCSC and
Ensembl,
Transcription factor binding sites according to
SABiosciences) About This Section
| Genomic View: UCSC Golden Path with GeneCards custom track
Transcription factor binding sites upstream to the AFP gene 
Entrez Gene cytogenetic band: 4q11-q13 Ensembl cytogenetic band: 4q13.3 HGNC cytogenetic band: 4q11-q13AFP Gene in genomic location: bands according to Ensembl, locations according to
(and/or Entrez Gene and/or Ensembl if different)
 GeneLoc gene densities for chromosome 4 GeneLoc Exon Structure GeneLoc location for GC04P074541:
(about GC identifiers)
Start:
|
74,520,744 bp from pter |
End:
|
74,540,358 bp from pter |
Size:
|
19,615 bases |
Orientation:
|
plus strand |
RefSeq DNA sequence:- NC_000004.10 NT_006216.14
| Proteins for AFP
(According to
1UniProtKB,
and/or Ensembl,
Phosphorylation sites according to 2Phosphosite,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from Invitrogen,
Millipore,
Sigma-Aldrich,
R&D Systems,
Enzo Life Sciences,
Abnova,
OriGene and/or,
Abcam,
Biochemical Assays by
Invitrogen,
Millipore,
R&D Systems,
Cell Signaling Technology, and/or
Enzo Life Sciences,
Ontologies according to Gene
Ontology Consortium 01 Apr 2009 and
Entrez Gene,
Antibodies by Invitrogen,
Millipore,
Sigma-Aldrich,
R&D Systems,
Cell Signaling Technology,
Abcam,
Abnova, and/or
Novus Biologicals)
About This Section
| UniProtKB/Swiss-Prot: FETA_HUMAN, P02771 (See
protein sequence)Recommended Name: Alpha-fetoprotein precursor Size: 609 amino acids; 68678 Da
Subunit: Dimeric and trimeric forms have been found in addition to the monomeric form
Subcellular location: Secreted
Developmental stage: Occurs in the plasma of fetuses more than 4 weeks old, reaches the highest levels during the 12th-16th week of gestation, and drops to trace amounts after birth. The serum level in adults is usually less than 40 ng/ml. AFP occurs also at high levels in the plasma and ascitic fluid of adults with hepatoma
Secondary accessions: B2RBU3Post-translational modifications:
Independent studies suggest heterogeneity of the N-terminal sequence of the mature protein and of the cleavage site of the signal sequence1
Sulfated1
View phosphorylation sites using PhosphoSite2
REFSEQ proteins: NP_001125.1
ENSEMBL proteins: ENSP00000379138 ENSP00000226359
Human Recombinant Proteins               OriGene Purified Recombinant Human Protein: AFP 
3 Gene Ontology (GO) cellular component terms (links to tree view): About this table
Antibodies for AFP: Assays for AFP: | Protein
Domains/ Families for AFP(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
| - Graphical View of Domain Structure for InterPro Entry P02771
ProtoNet protein and cluster: P02771 2 Blocks protein families: IPB000264 Serum albumin family IPB001703 Alpha-fetoprotein signature
UniProtKB/Swiss-Prot: FETA_HUMAN, P02771Similarity: Belongs to the ALB/AFP/VDB familySimilarity: Contains 3 albumin domains | Gene Function for AFP
(According to MGI Jun 06 2009, UniProtKB,
IUBMB,and/or Genatlas,
shRNA from
OriGene,
Sigma-Aldrich, RNAi from
Sigma-Aldrich,
RNAi Products,
Clones, and
Q-PCR Products
from Invitrogen,
Millipore,
OriGene, and/or
Abnova,
siRNAs from
Applied Biosystems,
SYBR primers from OriGene,
Cell-based Assays from Millipore,
Ontologies according to Gene Ontology Consortium 01 Apr 2009 via
Entrez Gene.)
About This Section
|               OriGene 29mer shRNA kit in GFP-retroviral vector: NM_001134
Applied Biosystems Silencer® siRNAs for AFP
Sigma-Aldrich siRNA for AFP  Sigma-Aldrich shRNA for AFP  Explore Sigma-Aldrich super-pooled esiRNAs 
              OriGene GFP tagged cDNA clone in CMV expression vector: NM_001134                                  Myc/DDK tagged cDNA clone in CMV expression vector: NM_001134                                  untagged cDNA clone in CMV expression vector: NM_001134 
Primers: Browse
Quantitative PCR Central at Invitrogen for Q-PCR LUX™ Primers               OriGene genome-wide validated SYBR primer pairs: NM_001134
UniProtKB/Swiss-Prot: FETA_HUMAN, P02771Function: Binds copper, nickel, and fatty acids as well as, and bilirubin less well than, serum albumin. Only a small percentage (less than 2%) of the human AFP shows estrogen-binding propertiesGenatlas biochemistry entry for AFP:alpha-fetoprotein5 MGI mutant phenotypes (inferred from 4 alleles ) (MGI details for Afp):
3 Gene Ontology (GO) molecular function terms (links to tree view): About this table | Pathways & Interactions for AFP
(Pathways according to Invitrogen
(maps by GeneGo),
Millipore,
Cell Signaling Technology,
Sigma-Aldrich,
KEGG
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Proteins Network according to
SABiosciences,
Interactions according to 1UniProtKB,
2MINT, and/or
3STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Apr 2009 via
Entrez Gene.)
About This Section
| 3 Sigma-Aldrich "Your Favorite Gene" Pathways for AFP (Your Favorite Gene powered by Ingenuity) 
Gene Network CentralTM Interacting Genes and Proteins Network for AFP 
5/64 Interacting proteins for AFP (P027712 ENSP000002263593) via UniProtKB, MINT, and/or STRING (see all 64
)About this table
4 Gene Ontology (GO) biological process terms (links to tree view): About this table
|
Drugs & Compounds for AFP(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
Sigma-Aldrich, Tocris Bioscience, and/or
Novoseek and Drugs according to
Enzo Life Sciences and/or
PharmGKB)
About This Section
|
Browse Tocris compounds for AFP 10/51 Novoseek chemical compound relationships for AFP gene (see all 51
)
| Compound |
Score |
Articles |
PubMed IDs for Articles with Shared Sentences (# sentences) |
| oestriol |
86.99 |
61 |
9795869 (2), 7479589 (1), 8904471 (1), 10589060 (1) (see all 58) |
| lipiodol |
71.81 |
9 |
11895553 (2), 16258102 (1), 16333675 (1), 7511068 (1) (see all 6) |
| nitrazine |
64.02 |
12 |
1695510 (5), 8902437 (4), 7586524 (3) |
| ntbc |
46.50 |
2 |
17008115 (2) |
| cis-diaminodichloroplatinum |
41.58 |
2 |
8391290 (1) |
| n-acetylglucosamine |
23.21 |
11 |
8894307 (2), 10355508 (1), 7679920 (1), 11679535 (1) (see all 8) |
| n-succinimidyl 3-(2-pyridyldithio)propionate |
22.77 |
2 |
1704234 (1) |
| ethanol |
22.76 |
7 |
11379338 (1), 11788887 (1), 15363186 (1), 15813715 (1) (see all 6) |
| europium |
21.30 |
3 |
10704020 (1), 7691439 (1) |
| con a |
18.44 |
18 |
1704432 (4), 8652249 (3), 1690592 (1), 8893165 (1) (see all 7) |
About this table
|
Transcripts for AFP(GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 219 Homo sapiens; Jun 2 2009) or GenBank, RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
non coding RNAs according to
RNAdb,
ESTs according to GeneTide,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from Invitrogen,
Millipore, and/or
Abnova,
siRNAs from Applied Biosystems,
Sigma-Aldrich,
shRNA from
Sigma-Aldrich,
OriGene,
Tagged/untagged cDNA clones from
OriGene, Expression Assays from Applied Biosystems) About This Section
|               OriGene 29mer shRNA kit in GFP-retroviral vector: NM_001134
Sigma-Aldrich siRNA for AFP  Sigma-Aldrich shRNA for AFP  Explore Sigma-Aldrich super-pooled esiRNAs 
Applied Biosystems Silencer® siRNAs: NM_001134 REFSEQ mRNAs for AFP gene: NM_001134.1
Applied Biosystems TaqMan ® Gene Expression Assays: NM_001134               OriGene GFP tagged cDNA clone in CMV expression vector: NM_001134                                  Myc/DDK tagged cDNA clone in CMV expression vector: NM_001134                                  untagged cDNA clone in CMV expression vector: NM_001134  Additional cDNA sequence: AF484525.1 AF484526.1 AK297669.1 AK297674.1 AK314817.1 BC027881.1 CR602918.1 CR603328.1 CR608054.1 CR608871.1 CR610573.1 CR616557.1 CR618771.1 CR621004.1 CR625428.1 CR625429.1 V01514.1 21 DOTS entries: DT.95165242 DT.100871902 DT.449398 DT.100871898 DT.121276106 DT.100871901 DT.100871907 DT.121276084 DT.100871914 DT.92458729 DT.95165257 DT.121276107 DT.75179602 DT.92458727 DT.95165243 DT.95165265 DT.100651994 DT.100871911 DT.121276061 DT.92458758 DT.95165245 24/535 AceView cDNA sequences (see all 535
):AU120529 AF484525 AW594198 AA333822 CR608054 AU076699 H94548 AU120341 AU121108 AU120511 AU120294 V01514 AU120987 AU121049 BX346088 AA334643 AU120814 AU120336 AA334621 AI990611 H94018 AU121094 AU121308 AU120127
highest scoring ESTs for AFP:AA677021 AI174905 AI652420 AL531238 AL531608 AL564175 AL579817 AL579859 AV699872 BC027881 Unigene Cluster for AFP: Alpha-fetoprotein Hs.518808 [show with all ESTs]Unigene Representative Sequence: BC027881
GeneLoc Exon Structure
2 Ensembl transcripts including schematic representations: ENST00000395792
ENST00000226359
|
Expression for AFP
(Experimental results according to
1GeneNote
and GNF BioGPS,
probe sets-to-genes annotations according to
2GeneAnnot ,
3GeneTide ,
Sets of similar genes according to GeneDecks,
Electronic Northern calculations according to data from
UniGene (Build 219 Homo sapiens),
SAGE tags according to
CGAP,
plus additional links to
SOURCE, and/or
GNF
BioGPS, and/or
EXPOLDB, and/or
UniProtKB,
Expression Assays from
Applied Biosystems
)
About This Section
| AFP expression in normal and diseased human tissues
Applied Biosystems TaqMan ® Gene Expression Assays for AFP
1 / 2 / 3 3 probe-sets matching AFP gene Data from
(Publications) and GNF BioGPS About these images About these images
CGAP SAGE TAG: AATATTCAAG
SOURCE GeneReport for Unigene cluster: Hs.518808
Expression variation in blood from EXPOLDB for AFP UniProtKB/Swiss-Prot: FETA_HUMAN, P02771Tissue specificity: Plasma. Synthesized by the fetal liver and yolk sac |
Orthologs for AFP
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
and/or
5MGI Jun 06 2009,
with possible further links to
Flybase
and/or
WormBase,
Gene Trees according to Ensembl)
About This Section
|
Orthologs for AFP gene from 5 species
About this table Species with no ortholog for AFP
ENSEMBL Gene Tree for AFP | Paralogs for AFP(Paralogs according to 1HomoloGene and 2Ensembl, Pseudogenes according to 3Pseudogene.org) About This Section
| Paralogs for AFP gene
- AFM2 ALB2 GC2
|
SNPs/Variants for AFP(According to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE, and
UniProtKB,
Linkage Disequilibrium by HapMap,
Genotyping Reagents from
Applied Biosystems)
About This Section
|
HapMap Linkage Disequilibrium images for AFP (up to first 250kb)
|
Disorders & Mutations for AFP
(in which this Gene is Involved, According to
OMIM, UniProtKB,
Novoseek, PharmGKB,
Genatlas, GeneTests,
Blood group antigen gene mutations by BGMUT,
HGMD, GAD,
HuGE Navigator,
BCGD,
and/or TGDB.)
About This Section
|
OMIM: 104150 10/94 Novoseek disease relationships for AFP gene (see all 94
)
| Disease |
Score |
Articles |
PubMed IDs for Articles with Shared Sentences (# sentences) |
| hepatocellular carcinoma |
94.03 |
618 |
17250819 (8), 12834318 (7), 7686840 (5), 9754243 (5) (see all 99) |
| yolk sac tumor |
89.67 |
63 |
15924879 (3), 17197899 (3), 1691611 (3), 9094031 (2) (see all 42) |
| down syndrome |
82.56 |
214 |
9639764 (5), 8649703 (5), 11679535 (4), 11002446 (4) (see all 99) |
| hepatoblastoma |
79.63 |
62 |
9094031 (4), 10626849 (4), 18525464 (3), 17535089 (2) (see all 33) |
| cirrhosis |
78.93 |
160 |
15004489 (3), 9166938 (3), 16136646 (3), 17767898 (3) (see all 99) |
| liver cirrhosis |
78.65 |
96 |
10355508 (5), 1717126 (5), 17288606 (3), 1709347 (2) (see all 69) |
| tumors |
78.33 |
1283 |
8646674 (6), 9118030 (4), 12209753 (4), 9422080 (4) (see all 99) |
| teratoma |
76.21 |
41 |
10386812 (3), 9258169 (2), 11745252 (2), 7685750 (2) (see all 31) |
| neural tube defects |
71.98 |
45 |
11002446 (4), 8284287 (3), 8878277 (2), 12848450 (2) (see all 35) |
| testicular yolk sac tumor |
71.66 |
3 |
1690592 (1), 19000459 (1) |
About this table
Human Gene Mutation Database: AFP Human Genome Epidemiology Navigator: AFP (6 documents)
|
Medical News for AFP(Possibly Related Articles in
Doctor's Guide)
About This Section
| |
Publications for AFP (in
PubMed.
Associations of this gene to articles via
1Novoseek,
2HGNC,
3Entrez Gene,
4UniProtKB/Swiss-Prot,
5UniProtKB/TrEMBL,
6GAD, and/or
7PharmGKB)
About This Section
| 10/1550 PubMed articles for AFP gene (see all 1550
):- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)3, 4 Gerhard D.S....Malek J. (2004)
- A G-->A substitution in an HNF I binding site in the human alpha- fetoprotein gene is associated with hereditary persistence of alpha- fetoprotein (HPAFP). (PubMed id 7684942)3, 4 McVey J.H.... Tuddenham E.G.D. (1993)
- Human alpha-fetoprotein primary structure: a mass spectrometric study. (PubMed id 1709810)3, 4 Pucci P.... Terrana B. (1991)
- Structure, polymorphism, and novel repeated DNA elements revealed by a complete sequence of the human alpha-fetoprotein gene. (PubMed id 2436661)3, 4 Gibbs P.E.M.... Dugaiczyk A. (1987)
- The human alpha-fetoprotein gene. Sequence organization and the 5' flanking region. (PubMed id 2580830)3, 4 Sakai M....Tamaoki T. (1985)
- Tyrosine sulfation of proteins from the human hepatoma cell line HepG2. (PubMed id 2414772)3, 4 Liu M.C.... Lipmann F. (1985)
- Primary structures of human alpha-fetoprotein and its mRNA. (PubMed id 6192439)3, 4 Morinaga T.... Tamaoki T. (1983)
- Structure and evolution of human alpha-fetoprotein deduced from partial sequence of cloned cDNA. (PubMed id 6187626)3, 4 Beattie W.G. and Dugaiczyk A. (1982)
- Alpha-Fetoprotein as a carrier protein in plasma and its bilirubin- binding ability. (PubMed id 89900)3, 4 Aoyagi Y.... Ichida F. (1979)
- Copper(II)-binding ability of human alpha-fetoprotein. (PubMed id 80265)3, 4 Aoyagi Y.... Ichida F. (1978)
|
Search for AFP
(in PubMed,
OMIM, and NCBI Bookshelf) About This Section
|
|
Genome Databases showing AFP
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
and/or
H-InvDB)
About This Section
|
| Other Databases showing AFP
(According to HUGE)
About This Section
| -- |
Specialized Databases showing AFP(According to ATLAS, HORDE, IMGT, MTDB, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL, Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot) About This Section
|
| Name | Description |
| Wikipedia | http://en.wikipedia.org/wiki/Alpha-fetoprotein |
|
| | | About This Section
| --
| Services for AFP(Reagents available from Applied Biosystems, Antibodies and assays by Cell
Signaling Technology, Abcam, Novus Biologicals, Sigma-Aldrich, R&D Systems, Millipore, Abnova, and/or Invitrogen, Clones available from OriGene,and/or Invitrogen, Drugs and/or compounds by Sigma-Aldrich, Enzo Life Sciences, and/or Tocris Bioscience) About This Section
| 
 Products for AFP:

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Incremental update: 13 Oct 2009
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