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AFP Gene

protein-coding   GIFtS: 65

GC04P074541
alpha-fetoprotein
Symbol approved by the HUGO Gene Nomenclature Committee (HGNC) database
(Previous symbol: HPAFP)
Services    

Aliases &
Descriptions
for AFP

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc , and/or 7Ensembl, 8miRBase)
About This Section
Aliases
Alpha-1-fetoprotein 3
Alpha-fetoglobulin 3
FETA 1, 2
HP 5
HPAFP 2, 3
OTTHUMP00000160480 2
alpha-1-fetoprotein 2
alpha-fetoglobulin 2
alpha-fetoprotein 2
External Ids
HGNC: 3171
Entrez Gene: 1742
UniProtKB: P027713
Ensembl: ENSG000000810517
Search outside databases for aliases for AFP gene

Previous GC identifers: GC04P074291 GC04P074703 GC04P074768 GC04P074666

Summaries
for AFP

(According to Entrez Gene, Wikipedia's Gene Wiki,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

 EntrezGene summary for AFP:
This gene encodes alpha-fetoprotein, a major plasma protein produced by the yolk sac and the liver
during fetal life. Alpha-fetoprotein expression in adults is often associated with hepatoma or
teratoma. However, hereditary persistance of alpha-fetoprotein may also be found in individuals
with no obvious pathology. The protein is thought to be the fetal counterpart of serum albumin,
and the alpha-fetoprotein and albumin genes are present in tandem in the same transcriptional
orientation on chromosome 4. Alpha-fetoprotein is found in monomeric as well as dimeric and
trimeric forms, and binds copper, nickel, fatty acids and bilirubin. The level of
alpha-fetoprotein in amniotic fluid is used to measure renal loss of protein to screen for spina
bifida and anencephaly. [provided by RefSeq]

UniProtKB/Swiss-Prot: FETA_HUMAN, P02771
Function: Binds copper, nickel, and fatty acids as well as, and bilirubin less well than, serum
albumin. Only a small percentage (less than 2%) of the human AFP shows estrogen-binding properties

Gene Wiki entry for AFP (Alpha-fetoprotein)

Genomic Location
for AFP

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 36),
and/or miRBase,
Genomic Views according to UCSC and Ensembl, Transcription factor binding sites according to SABiosciences)
About This Section

 Genomic View:
UCSC Golden Path with GeneCards custom track

 Transcription factor binding sites upstream to the AFP gene  

Entrez Gene cytogenetic band: 4q11-q13   Ensembl cytogenetic band:  4q13.3   HGNC cytogenetic band: 4q11-q13

AFP Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)

GeneLoc gene densities for chromosome 4         GeneLoc Exon Structure

GeneLoc location for GC04P074541:     (about GC identifiers)

Start:
 74,520,744 bp from pter
End:
 74,540,358 bp from pter
Size:
 19,615 bases
Orientation:
 plus strand
RefSeq DNA sequence:
NC_000004.10  NT_006216.14  

Proteins
for AFP

(According to 1UniProtKB, and/or Ensembl, Phosphorylation sites according to 2Phosphosite, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Enzo Life Sciences, Abnova, OriGene and/or, Abcam,
Biochemical Assays by Invitrogen, Millipore, R&D Systems, Cell Signaling Technology, and/or Enzo Life Sciences, Ontologies according to Gene Ontology Consortium 01 Apr 2009 and Entrez Gene, Antibodies by Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Cell Signaling Technology, Abcam, Abnova, and/or Novus Biologicals)
About This Section

 UniProtKB/Swiss-Prot: FETA_HUMAN, P02771 (See protein sequence)
Recommended Name: Alpha-fetoprotein precursor  
Size: 609 amino acids; 68678 Da
Subunit: Dimeric and trimeric forms have been found in addition to the monomeric form
Subcellular location: Secreted
Developmental stage: Occurs in the plasma of fetuses more than 4 weeks old, reaches the highest
levels during the 12th-16th week of gestation, and drops to trace amounts after birth. The serum
level in adults is usually less than 40 ng/ml. AFP occurs also at high levels in the plasma and
ascitic fluid of adults with hepatoma
Secondary accessions: B2RBU3

Post-translational modifications:

  • Independent studies suggest heterogeneity of the N-terminal sequence of the mature protein and of
    the cleavage site of the signal sequence1
  • Sulfated1
  • View phosphorylation sites using PhosphoSite2


    • REFSEQ proteins: NP_001125.1  

    ENSEMBL proteins: 
    ENSP00000379138 ENSP00000226359 


    Human Recombinant Proteins 
    Browse Drug Discovery Central at Invitrogen for human recombinant proteins
    Browse Purified and Recombinant Proteins at Millipore
    Browse Human Recombinant Proteins at Sigma-Aldrich  
    Browse R&D Systems for human recombinant proteins
    Browse recombinant and purified proteins available from Enzo Life Sciences
    Recombinant Proteins from Abcam (alpha 1 Fetoprotein, alpha Fetoprotein)
    Human Recombinant Proteins from Abnova (AFP)
                  OriGene Purified Recombinant Human Protein: AFP 

    3 Gene Ontology (GO) cellular component terms (links to tree view):

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005576 extracellular region IEA--
    GO:0005615 extracellular space IEA--
    GO:0005737 cytoplasm IEA--
    About this table

    Antibodies for AFP: 
    Invitrogen Antibodies for AFP
    Browse Millipore's Extensive Line of Mono- and Polyclonal Antibodies
    Sigma-Aldrich Antibodies for AFP
    R&D Systems Antibodies for AFP (alpha-Fetoprotein/AFP)
    Cell Signaling Technology (CST) Antibodies for AFP 
    Antibodies from Abcam (alpha 1 Fetoprotein, alpha Fetoprotein), each with their AbpromiseSM
    Monoclonal and Polyclonal Antibodies from Abnova (AFP)
    Novus Biologicals Antibodies for FETA

    Assays for AFP: 
    Browse Invitrogen for biochemical assays
    Browse Kits and Assays available from Millipore
    R&D Systems ELISAs for AFP (alpha-Fetoprotein/AFP)         (see all)
    Browse biochemical assays available from Enzo Life Sciences

    Protein Domains/
    Families
    for AFP

    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    3 InterPro domains/families:
     IPR000264 Serum_albumin
     IPR001703 Alpha-fetoprotein
     IPR014760 Serum_albumin_N


       GeneDecks  AFP for the domains selected above  
    About GeneDecksing

    Graphical View of Domain Structure for InterPro Entry P02771

    ProtoNet protein and cluster: P02771

    2 Blocks protein families:
    IPB000264 Serum albumin family
    IPB001703 Alpha-fetoprotein signature


    UniProtKB/Swiss-Prot: FETA_HUMAN, P02771
    Similarity: Belongs to the ALB/AFP/VDB family
    Similarity: Contains 3 albumin domains

    Gene Function
    for AFP

    (According to MGI Jun 06 2009, UniProtKB, IUBMB,and/or Genatlas,
    shRNA from OriGene, Sigma-Aldrich, RNAi from Sigma-Aldrich,
    RNAi Products, Clones, and Q-PCR Products from Invitrogen, Millipore, OriGene, and/or Abnova, siRNAs from Applied Biosystems, SYBR primers from OriGene, Cell-based Assays from Millipore, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
    About This Section
    Inhib.
    RNA:    		Invitrogen RNAi Products for gene knock-down (AFP)
    Browse for Gene Knock-down Tools from Millipore
    Abnova Chimera RNAi Products for Gene knock-down (AFP)
                  OriGene 29mer shRNA kit in GFP-retroviral vector: NM_001134

                  Applied Biosystems Silencer® siRNAs for AFP

                  Sigma-Aldrich siRNA for AFP  
                         Sigma-Aldrich shRNA for AFP  
                         Explore Sigma-Aldrich super-pooled esiRNAs  

    Clones:Invitrogen Clones for AFP
    Browse Clones for the Expression of Recombinant Proteins Available from Millipore
                  OriGene GFP tagged cDNA clone in CMV expression vector: NM_001134
                                     Myc/DDK tagged cDNA clone in CMV expression vector: NM_001134
                                     untagged cDNA clone in CMV expression vector: NM_001134 

    Primers: Browse Quantitative PCR Central at Invitrogen for Q-PCR LUX™ Primers
                  OriGene genome-wide validated SYBR primer pairs: NM_001134

    UniProtKB/Swiss-Prot: FETA_HUMAN, P02771
    Function: Binds copper, nickel, and fatty acids as well as, and bilirubin less well than, serum
    albumin. Only a small percentage (less than 2%) of the human AFP shows estrogen-binding properties

    Genatlas biochemistry entry for AFP:
    alpha-fetoprotein

    5 MGI mutant phenotypes (inferred from 4 alleles) (MGI details for Afp):

    behavior/neurologicalendocrine/exocrine glandhomeostasis/metabolismreproductive systemtumorigenesis

    3 Gene Ontology (GO) molecular function terms (links to tree view):

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005507 copper ion binding IEA--
    GO:0016151 nickel ion binding IEA--
    GO:0046872 metal ion binding IEA--
    About this table

    Pathways & Interactions
    for AFP

    (Pathways according to Invitrogen (maps by GeneGo), Millipore, Cell Signaling Technology, Sigma-Aldrich, KEGG and/or UniProtKB,
    Sets of similar genes according to GeneDecks, Proteins Network according to SABiosciences, Interactions according to 1UniProtKB, 2MINT, and/or 3STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
    About This Section


    3 Sigma-Aldrich "Your Favorite Gene" Pathways for  AFP  (Your Favorite Gene powered by Ingenuity) 
     Pentose and Glucuronate Interconversions
     Glycosaminoglycan Degradation
     Starch and Sucrose Metabolism

       GeneDecks  AFP for the pathways selected above  
    About GeneDecksing

     Gene Network CentralTM Interacting Genes and Proteins Network for  AFP 


    5/64 Interacting proteins for AFP (P027712 ENSP000002263593) via UniProtKB, MINT, and/or STRING (see all 64 )
    InteractantInteraction Details
    GeneCardExternal ID(s)
    SGSM2O431472MINT-64867
    HNF1AENSP000002575553STRING (score=.973)
    FOXA3ENSP000003040043STRING (score=.966)
    HGFENSP000002223903STRING (score=.964)
    FOXA1ENSP000002504483STRING (score=.961)
    About this table

    4 Gene Ontology (GO) biological process terms (links to tree view):

    GO IDQualified GO termEvidencePubMed IDs
    GO:0001542 ovulation from ovarian follicle IEA--
    GO:0006810 transport IEA--
    GO:0019953 sexual reproduction IEA--
    GO:0042448 progesterone metabolic process IEA--
    About this table

    Drugs & Compounds
    for AFP

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, Sigma-Aldrich, Tocris Bioscience, and/or Novoseek and Drugs according to Enzo Life Sciences and/or PharmGKB)
    About This Section

    Browse drugs & compounds from Enzo Life Sciences
    Browse Small Molecules at Sigma-Aldrich

    Browse Tocris compounds for AFP
    10/51 Novoseek chemical compound relationships for AFP gene (see all 51 )
    Compound   Score   Articles   PubMed IDs for Articles with Shared Sentences (# sentences)
    oestriol 86.99 61 9795869 (2), 7479589 (1), 8904471 (1), 10589060 (1) (see all 58)
    lipiodol 71.81 9 11895553 (2), 16258102 (1), 16333675 (1), 7511068 (1) (see all 6)
    nitrazine 64.02 12 1695510 (5), 8902437 (4), 7586524 (3)
    ntbc 46.50 2 17008115 (2)
    cis-diaminodichloroplatinum 41.58 2 8391290 (1)
    n-acetylglucosamine 23.21 11 8894307 (2), 10355508 (1), 7679920 (1), 11679535 (1) (see all 8)
    n-succinimidyl 3-(2-pyridyldithio)propionate 22.77 2 1704234 (1)
    ethanol 22.76 7 11379338 (1), 11788887 (1), 15363186 (1), 15813715 (1) (see all 6)
    europium 21.30 3 10704020 (1), 7691439 (1)
    con a 18.44 18 1704432 (4), 8652249 (3), 1690592 (1), 8893165 (1) (see all 7)
    About this table


    Transcripts
    for AFP

    (GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 219 Homo sapiens; Jun 2 2009) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView,
    non coding RNAs according to RNAdb,
    ESTs according to GeneTide,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from Invitrogen, Millipore, and/or Abnova,
    siRNAs from Applied Biosystems, Sigma-Aldrich,
    shRNA from Sigma-Aldrich, OriGene,
    Tagged/untagged cDNA clones from OriGene,
    Expression Assays from Applied Biosystems)
    About This Section
    Inhib.
    RNA:    		Invitrogen RNAi Products for gene knock-down (AFP)
    Browse for Gene Knock-down Tools from Millipore
    Abnova Chimera RNAi Products for Gene knock-down (AFP)
                  OriGene 29mer shRNA kit in GFP-retroviral vector: NM_001134

                  Sigma-Aldrich siRNA for AFP  
                         Sigma-Aldrich shRNA for AFP  
                         Explore Sigma-Aldrich super-pooled esiRNAs  

    Applied Biosystems Silencer® siRNAs: 

    NM_001134  

    REFSEQ mRNAs for AFP gene: 

    NM_001134.1   

    Applied Biosystems TaqMan ® Gene Expression Assays: 

    NM_001134  

                  OriGene GFP tagged cDNA clone in CMV expression vector: NM_001134
                                     Myc/DDK tagged cDNA clone in CMV expression vector: NM_001134
                                     untagged cDNA clone in CMV expression vector: NM_001134 

    Additional cDNA sequence: 

    AF484525.1 AF484526.1 AK297669.1 AK297674.1 AK314817.1 BC027881.1 CR602918.1 CR603328.1 
    CR608054.1 CR608871.1 CR610573.1 CR616557.1 CR618771.1 CR621004.1 CR625428.1 CR625429.1 
    V01514.1 

    21 DOTS entries:

    DT.95165242  DT.100871902  DT.449398  DT.100871898  DT.121276106  DT.100871901  DT.100871907  DT.121276084 
    DT.100871914  DT.92458729  DT.95165257  DT.121276107  DT.75179602  DT.92458727  DT.95165243  DT.95165265 
    DT.100651994  DT.100871911  DT.121276061  DT.92458758  DT.95165245 

    24/535 AceView cDNA sequences (see all 535 ):

    AU120529 AF484525 AW594198 AA333822 CR608054 AU076699 H94548 AU120341 
    AU121108 AU120511 AU120294 V01514 AU120987 AU121049 BX346088 AA334643 
    AU120814 AU120336 AA334621 AI990611 H94018 AU121094 AU121308 AU120127 

    highest scoring ESTs for AFP:

    AA677021 AI174905 AI652420 AL531238 AL531608 AL564175 AL579817 AL579859 AV699872 BC027881 

    Unigene Cluster for AFP:

    Alpha-fetoprotein
    Hs.518808  [show with all ESTs]
    Unigene Representative Sequence: BC027881


    GeneLoc Exon Structure

    2 Ensembl transcripts including schematic representations:
    ENST00000395792  ENST00000226359  

    Expression
    for AFP

    (Experimental results according to 1GeneNote and GNF BioGPS,
    probe sets-to-genes annotations according to 2GeneAnnot , 3GeneTide , Sets of similar genes according to GeneDecks, Electronic Northern calculations according to data from UniGene (Build 219 Homo sapiens), SAGE tags according to CGAP, plus additional links to SOURCE, and/or GNF BioGPS, and/or EXPOLDB, and/or UniProtKB,
    Expression Assays from Applied Biosystems )
    About This Section

    AFP expression in normal and diseased human tissues

     Applied Biosystems TaqMan ® Gene Expression Assays for AFP

    1 / 2 / 3

    3 probe-sets matching AFP gene


    		Affymetrix
    probe-set    		 Array  GeneAnnot data GeneNote data GeneTide data
    # genes Sensitivity Specificity Correlation Length Gb_Accession Consensus Uniqueness Score Rank

    		40114_at2, 3 U95-A 1 0.94 1.00 1.00 1.00 J00077 0.40 1.00 0.76 1

    		204694_at2, 3 U133-A 1 1.00 1.00 -- -- NM_001134 0.60 1.00 0.82 1

    		204694_at2 U133Plus2 1 1.00 1.00 -- -- -- -- -- -- --
    About this table
    Data from (Publications) and GNF BioGPS
        About these images
    About these images

    CGAP SAGE TAG: AATATTCAAG

    SOURCE GeneReport for Unigene cluster: Hs.518808

    Expression variation in blood from EXPOLDB for AFP

    UniProtKB/Swiss-Prot: FETA_HUMAN, P02771
    Tissue specificity: Plasma. Synthesized by the fetal liver and yolk sac

    Orthologs
    for AFP

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD and/or 5MGI Jun 06 2009, with possible further links to Flybase and/or WormBase, Gene Trees according to Ensembl)
    About This Section
    Orthologs for AFP gene from 5 species
    Organism Gene Locus Description Human
    Similarity    		 NCBI accessions
    dog
    (Canis familiaris)    		 AFP1   -- alpha-fetoprotein 87.25(n)
    84.07(a)    		 403551  NM_001003027.1  NP_001003027.1 
    chimpanzee
    (Pan troglodytes)    		 AFP1   -- alpha-fetoprotein 99.45(n)
    99.18(a)    		 461258  XM_517231.2  XP_517231.2 
    cow
    (Bos taurus)    		 AFP1   -- alpha-fetoprotein 84.78(n)
    78.33(a)    		 506011  NM_001034262.1  NP_001029434.1 
    rat
    (Rattus norvegicus)    		 Afp1   -- alpha-fetoprotein 74.38(n)
    65.45(a)    		 24177  NM_012493.1  NP_036625.1 
    mouse
    (Mus musculus)    		 Afp1, 5 5 (50.00 cM)5
    		 alpha fetoprotein1, 5 75.48(n)1
    65.62(a)1    		 115761  NM_007423.31  NP_031449.21 
     AH0018425  AK0109345  (see all 39)
    About this table        Species with no ortholog for AFP

    ENSEMBL Gene Tree for AFP

    Paralogs
    for AFP

    (Paralogs according to 1HomoloGene
    and 2Ensembl, Pseudogenes according to 3Pseudogene.org)
    About This Section

    Paralogs for AFP gene
    AFM2  ALB2  GC2  

    SNPs/Variants
    for AFP

    (According to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, and UniProtKB, Linkage Disequilibrium by HapMap, Genotyping Reagents from Applied Biosystems)
    About This Section


    10/103 NCBI SNPs in AFP are shown (see all 103 )
    (Click for Applied Biosystems TaqMan ® Genotyping Assay)  (see all 74)
    ABGenomic DataTranscription DataAllele Frequencies
    SNP IDValidChr 4 posSequenceRecsAA
    Chg    		TypeMoreRecsAllele
    freq    		PopTotal
    sample    		More
    ------------
    rs40181,2
    		A,C,F,H,O74520177(+) GCATAT/CTAAAT 1 -- ng517Minor allele frequency- C:0.47NA EU EA WA 540
    rs68340591,2
    		A,C,F,H74520539(+) GTCATC/GTCTTT 1 -- ng514Minor allele frequency- G:0.27EU EA WA 418
    rs100204321,2
    		A,C,F,H74540464(+) TGGTTG/ATTATA 1 -- ng317Minor allele frequency- A:0.43NA EU EA WA 558
    rs40241,2
    		A,C,F,H74520248(+) TGACAA/GCATAA 1 -- ng515Minor allele frequency- G:0.46MN EU EA WA 598
    rs44462791,2
    		A,C,F,H74519474(+) GCATAC/GTGCTC 1 -- ng518Minor allele frequency- G:0.27EU EA WA 838
    rs77901,2
    		C,F,H74538402(+) TGAGGC/GTGTCA 1 A/G mis112Minor allele frequency- G:0.42NA EU EA WA 1056
    rs126515811,2
    		C,F,H74519744(+) TTTGAT/CGGCTG 1 -- ng514Minor allele frequency- C:0.09EU EA WA 418
    rs357656191,2
    		C,F74526953(+) ATGACA/CAAATA 1 K/Q mis15Minor allele frequency- C:0.01NA EU EA WA 498
    rs68152131,2
    		F,H74520202(+) CTTATT/CGACAT 1 -- ng51 tfbs34Minor allele frequency- C:0.01EU EA WA 416
    rs18942641,2
    		C,F,H74535241(+) TCGTCG/AGAGCT 1 S/S syn1 ese35Minor allele frequency- A:0.02EU EA WA NA 478
    About this table

    HapMap Linkage Disequilibrium images for AFP (up to first 250kb)

    Disorders & Mutations
    for AFP

    (in which this Gene is Involved, According to OMIM, UniProtKB, Novoseek, PharmGKB, Genatlas, GeneTests, Blood group antigen gene mutations by BGMUT, HGMD, GAD, HuGE Navigator, BCGD, and/or TGDB.)
    About This Section

    		 OMIM: 104150

    10/94 Novoseek disease relationships for AFP gene (see all 94 )

    Disease   Score   Articles   PubMed IDs for Articles with Shared Sentences (# sentences)
    hepatocellular carcinoma 94.03 618 17250819 (8), 12834318 (7), 7686840 (5), 9754243 (5) (see all 99)
    yolk sac tumor 89.67 63 15924879 (3), 17197899 (3), 1691611 (3), 9094031 (2) (see all 42)
    down syndrome 82.56 214 9639764 (5), 8649703 (5), 11679535 (4), 11002446 (4) (see all 99)
    hepatoblastoma 79.63 62 9094031 (4), 10626849 (4), 18525464 (3), 17535089 (2) (see all 33)
    cirrhosis 78.93 160 15004489 (3), 9166938 (3), 16136646 (3), 17767898 (3) (see all 99)
    liver cirrhosis 78.65 96 10355508 (5), 1717126 (5), 17288606 (3), 1709347 (2) (see all 69)
    tumors 78.33 1283 8646674 (6), 9118030 (4), 12209753 (4), 9422080 (4) (see all 99)
    teratoma 76.21 41 10386812 (3), 9258169 (2), 11745252 (2), 7685750 (2) (see all 31)
    neural tube defects 71.98 45 11002446 (4), 8284287 (3), 8878277 (2), 12848450 (2) (see all 35)
    testicular yolk sac tumor 71.66 3 1690592 (1), 19000459 (1)
    About this table

    Human Gene Mutation Database: AFP
    Human Genome Epidemiology Navigator: AFP (6 documents)

    Medical News
    for AFP

    (Possibly Related Articles in Doctor's Guide)
    About This Section

    Publications
    for AFP

    (in PubMed. Associations of this gene to articles via 1Novoseek, 2HGNC, 3Entrez Gene, 4UniProtKB/Swiss-Prot, 5UniProtKB/TrEMBL, 6GAD, and/or 7PharmGKB)
    About This Section

    		10/1550 PubMed articles for AFP gene (see all 1550 ):

    Search for AFP

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section

     ANDOR
    Aliases
    Free Text  
      Query String
    		PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    Genome Databases showing AFP

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, and/or H-InvDB)
    About This Section
    Entrez Gene: 174 HGNC: 317 AceView: AFP Ensembl:ENSG00000081051 euGenes: HUgn174
    ECgene: AFP H-InvDB: AFP

    Other Databases showing AFP

    (According to HUGE)
    About This Section

    		   --

    Specialized Databases showing AFP

    (According to ATLAS, HORDE, IMGT, MTDB, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    Wikipedia http://en.wikipedia.org/wiki/Alpha-fetoprotein

    Licensable Technologies
    for AFP

    (Available from WIS Yeda, Salk, Tufts)
    About This Section

    		  --

    Services
    for AFP

    (Reagents available from Applied Biosystems, Antibodies and assays by Cell Signaling Technology, Abcam, Novus Biologicals,
    Sigma-Aldrich, R&D Systems, Millipore, Abnova, and/or Invitrogen, Clones available from OriGene,and/or Invitrogen, Drugs and/or compounds by Sigma-Aldrich,
    Enzo Life Sciences, and/or Tocris Bioscience)
    About This Section



    Products for AFP:
     TaqMan ® Gene Expression Assays
     TaqMan ® Genotyping Assays
    		  Free SNP selection tool



      Invitrogen iPath Pathways  Invitrogen BLOCK-iT™ RNAi
      Invitrogen Antibodies  Invitrogen Assays
      Invitrogen Clones  Invitrogen Q-PCR Products
      Invitrogen Human Recombinant Kinases  Invitrogen Custom Antibody and Peptide Service
      Invitrogen Proteins / Assays / Screening Services  Search Invitrogen catalog for AFP-related products

     Millipore Custom Antibody & Bulk Services
     Millipore Preclinical / Clinical Development Services
     Millipore Immunoassay Services
     Millipore Target Screening & Profiling Services


     Predesigned and custom siRNAs for AFP Antibodies for AFP
     Explore super-pooled esiRNAs Browse proteins at Sigma-Aldrich
     Lentivirus-delivered shRNAs for AFP Browse small molecules at Sigma-Aldrich
     "Your Favorite Gene" Pathwaysfeedback


      
     Antibodies   Primer Pairs  
     Cell Culture Products   ELISAs  
     Flow Cytometry Kits   Protease Activity Assays & Reagents  
     Cell Selection/Detection Kits & Reagents   ELISA/Assay Development Kits & Reagents  
     Multiplex/Array Assay Kits & Reagents   ELISpot Kits & Development Modules  
     Recombinant & Natural Proteins  

     Recombinant Proteins (AFP)
     Antibodies (AFP)
     Chimera RNAi (AFP)
     Custom Service for Mouse Mab
     Custom Service for Rabbit Pab from Full-length Protein
      
     Antibodies & Assays for AFP 

     Recombinant Proteins
    (alpha 1 Fetoprotein, alpha Fetoprotein)
     Antibodies (alpha 1 Fetoprotein, alpha Fetoprotein)
     Tagged/untagged cDNA clones
     Validated SYBR primer pairs
     Purified proteins from HEK293T cells
     Western blot validated antibodies
     shRNA in GFP-retroviral vector
     Search Tocris compounds for AFP




     Search www.enzolifesicences.com for proteins, assays, substrates, inhibitors & antibodies
     Antibodies for FETA

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