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AFMID Gene

protein-coding   GIFtS: 51
GCID: GC17P076183

Arylformamidase

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(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
arylformamidase1 2     N-Formylkynurenine Formamidase2 3
Arylformamidase3     KF2
FKF2 3     Kynurenine Formamidase2
KFA2 3     Probable Arylformamidase2
KFase2 3     EC 3.5.1.93

External Ids:    HGNC: 209101   Entrez Gene: 1250612   Ensembl: ENSG000001830777   UniProtKB: Q63HM13   

Export aliases for AFMID gene to outside databases

Previous GC identifers: GC17P076780 GC17U900085 GC17P073695 GC17P071607


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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GeneCards Summary for AFMID Gene:
AFMID (arylformamidase) is a protein-coding gene. GO annotations related to this gene include arylformamidase activity.

UniProtKB/Swiss-Prot: KFA_HUMAN, Q63HM1
Function: Catalyzes the hydrolysis of N-formyl-L-kynurenine to L-kynurenine, the second step in the kynurenine
pathway of tryptophan degradation. Kynurenine may be further oxidized to nicotinic acid, NAD(H) and NADP(H).
Required for elimination of toxic metabolites (By similarity)




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000017.10  NT_010783.16  NC_018928.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the AFMID gene promoter:
         Sp1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidAFMID promoter sequence
   Search Chromatin IP Primers for AFMID

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat AFMID


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 17q25.3   Ensembl cytogenetic band:  17q25.3   HGNC cytogenetic band: 17q25.3

AFMID Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
AFMID gene location

GeneLoc information about chromosome 17         GeneLoc Exon Structure

GeneLoc location for GC17P076183:  view genomic region     (about GC identifiers)

Start:
76,183,398 bp from pter      End:
76,203,782 bp from pter
Size:
20,385 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., and/or eBioscience,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., and/or eBioscience, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: KFA_HUMAN, Q63HM1 (See protein sequence)
Recommended Name: Kynurenine formamidase  
Size: 303 amino acids; 33992 Da
Subunit: Homodimer (By similarity)
Secondary accessions: A2RUB3
Alternative splicing: 2 isoforms:  Q63HM1-1   Q63HM1-2   (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for AFMID: NX_Q63HM1

Explore proteomics data for AFMID at MOPED

Post-translational modifications: 

  • Modification sites at neXtProt
  • Modification sites at PhosphoSitePlus

  • See AFMID Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (2 alternative transcripts): 
    NP_001010982.2  NP_001138998.1  

    ENSEMBL proteins: 
     ENSP00000386890   ENSP00000466515   ENSP00000466859   ENSP00000467869   ENSP00000465406  
     ENSP00000464929   ENSP00000467365   ENSP00000328938   ENSP00000466566   ENSP00000466241  
    Reactome Protein details: Q63HM1

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    Cloud-Clone Corp. Proteins for AFMID

     
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    AFMID Assay Products:

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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    2 InterPro protein domains:
     IPR027519 KFase
     IPR013094 AB_hydrolase_3

    Graphical View of Domain Structure for InterPro Entry Q63HM1

    ProtoNet protein and cluster: Q63HM1

    UniProtKB/Swiss-Prot: KFA_HUMAN, Q63HM1
    Domain: The main chain amide nitrogen atoms of the second glycine and its adjacent residue in the HGGXW motif
    define the oxyanion hole, and stabilize the oxyanion that forms during the nucleophilic attack by the catalytic
    serine during substrate cleavage (By similarity)
    Similarity: Belongs to the kynurenine formamidase family


    Find genes that share domains with AFMID           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: KFA_HUMAN, Q63HM1
    Function: Catalyzes the hydrolysis of N-formyl-L-kynurenine to L-kynurenine, the second step in the kynurenine
    pathway of tryptophan degradation. Kynurenine may be further oxidized to nicotinic acid, NAD(H) and NADP(H).
    Required for elimination of toxic metabolites (By similarity)
    Catalytic activity: N-formyl-L-kynurenine + H(2)O = formate + L-kynurenine

         Enzyme Number (IUBMB): EC 3.5.1.91

         Gene Ontology (GO): 2 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0004061arylformamidase activity IEA--
    GO:0016787hydrolase activity ----
         
    Find genes that share ontologies with AFMID           About GenesLikeMe


    Phenotypes:
         1 MGI mutant phenotype (inferred from 2 alleles(MGI details for Afmid):
     mortality/aging 

    Find genes that share phenotypes with AFMID           About GenesLikeMe

    Animal Models:
         MGI mouse knock-out Afmidtm1Vnd for AFMID

       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for AFMID
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       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for AFMID
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for AFMID

    miRNA
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    2 qRT-PCR Assays for microRNAs that regulate AFMID:
    hsa-miR-214 hsa-miR-761
    SwitchGear 3'UTR luciferase reporter plasmidAFMID 3' UTR sequence
    Inhib. RNA
    Products:
        
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    GenScript: all cDNA clones in your preferred vector (see all 2): AFMID (NM_001010982)
    Sino Biological Human cDNA Clone for AFMID
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for AFMID
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat AFMID

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    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    KFA_HUMAN, Q63HM1: Cytoplasm, cytosol (By similarity). Nucleus (By similarity). Note=Predominantly cytosolic.
    Some fraction is nuclear (By similarity)
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    cytosol2
    nucleus2
    mitochondrion1
    peroxisome1

    Gene Ontology (GO): 3 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus IEA--
    GO:0005737cytoplasm ----
    GO:0005829cytosol IEA--

    Find genes that share ontologies with AFMID           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for AFMID About   (see all 6)  
    See pathways by source

    SuperPathContained pathways About
    1Tryptophan metabolism
    Tryptophan metabolism0.46
    Tryptophan catabolism0.00
    Tryptophan metabolism0.46
    2Metabolism
    Metabolism0.38
    Metabolic pathways0.38
    3Metabolism of amino acids and derivatives
    Metabolism of amino acids and derivatives
    tryptophan degradation via kynurenine0.00
    4tryptophan utilization II
    tryptophan utilization II0.71
    NAD de novo biosynthesis0.00
    tryptophan utilization I0.71
    tryptophan degradation to 2-amino-3-carboxymuconate semialdehyde0.00
    tryptophan degradation0.00
    5Nicotinate and nicotinamide metabolism
    NAD metabolism0.43


    Find genes that share SuperPaths with AFMID           About GenesLikeMe

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways


    1 GeneGo (Thomson Reuters) Pathway for AFMID
        NAD metabolism

    Selected BioSystems Pathways for AFMID (see all 7)
        NAD de novo biosynthesis
    tryptophan degradation via kynurenine
    tryptophan degradation to 2-amino-3-carboxymuconate semialdehyde
    Tryptophan metabolism
    tryptophan degradation


    1 Reactome Pathway for AFMID
        Tryptophan catabolism


    3 Kegg Pathways  (Kegg details for AFMID):
        Tryptophan metabolism
    Glyoxylate and dicarboxylate metabolism
    Metabolic pathways

    UniProtKB/Swiss-Prot: KFA_HUMAN, Q63HM1
    Pathway: Amino-acid degradation; L-tryptophan degradation via kynurenine pathway; L-kynurenine from L-tryptophan:
    step 2/2

        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for AFMID
    Interactions:

        Search GeneGlobe Interaction Network for AFMID

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for AFMID (ENSP000003289384) via UniProtKB, MINT, STRING, and/or I2D (see all 27)

    InteractantInteraction Details
    GeneCardExternal ID(s)
    AADATENSP000002268404STRING: ENSP00000226840
    CCBL1ENSP000003022274STRING: ENSP00000302227
    CCBL2ENSP000002605084STRING: ENSP00000260508
    IDO1ENSP000002535134STRING: ENSP00000253513
    KMOENSP000003555174STRING: ENSP00000355517
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 6):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006569tryptophan catabolic process TAS--
    GO:0008152metabolic process ----
    GO:0019441tryptophan catabolic process to kynurenine IEA--
    GO:0034354'de novo' NAD biosynthetic process from tryptophan IEA--
    GO:0034641cellular nitrogen compound metabolic process TAS--

    Find genes that share ontologies with AFMID           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for AFMID (KFA)

    Selected HMDB Compounds for AFMID (see all 11)    About this table
    CompoundSynonyms CAS #PubMed Ids
    2-Aminobenzoic acid1-Amino-2-carboxybenzene (see all 30)118-92-3--
    5-Hydroxy-N-formylkynurenine ----
    5-Hydroxykynurenine5-Hydroxy-L-kynurenine 2208-41-5--
    Formic acidAdd-F (see all 21)64-18-6--
    Formylanthranilic acid2-(Formylamino)-benzoic acid (see all 8)3342-77-6--
    Hydroxykynurenine3-(3-hydroxyanthraniloyl)-Alanine (see all 7)484-78-6--
    L-Kynurenine(S)-alpha,2-diamino-3-hydroxy-gamma-oxo-Benzenebutanoate (see all 15)343-65-7--
    N'-Formylkynurenine3-(N-formylanthraniloyl)-Alanine (see all 9)1022-31-7--
    NAD3-Carbamoyl-1-D-ribofuranosylpyridinium hydroxide 5'-ester with adenosine 5'-pyrophosphate (see all 28)53-84-9--
    NADPAdenine-nicotinamide dinucleotide phosphate (see all 18)53-59-8--



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for AFMID gene (2 alternative transcripts): 
    NM_001010982.4  NM_001145526.2  

    Unigene Cluster for AFMID:

    Arylformamidase
    Hs.558614  [show with all ESTs]
    Unigene Representative Sequence: BX648442
    15 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000409257(uc002juy.3 uc010dhj.3 uc002jva.3 uc002jvb.3)
    ENST00000591256 ENST00000589256 ENST00000592988 ENST00000589107 ENST00000588199
    ENST00000588800 ENST00000591952 ENST00000327898(uc002juz.3) ENST00000586542
    ENST00000586731 ENST00000591538 ENST00000587750 ENST00000589664 ENST00000585419

    miRNA
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    2 qRT-PCR Assays for microRNAs that regulate AFMID:
    hsa-miR-214 hsa-miR-761
    SwitchGear 3'UTR luciferase reporter plasmidAFMID 3' UTR sequence
    Inhib. RNA
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    Additional mRNA sequence: 

    BC020920.1 BC132824.1 BX648442.1 NR_027083.1 

    12 DOTS entries:

    DT.92004595  DT.120947006  DT.105189  DT.91696102  DT.91730398  DT.95369749  DT.102831500  DT.120947013 
    DT.95369750  DT.120947018  DT.91885943  DT.92470911 

    Selected AceView cDNA sequences (see all 516):

    L32866 CR607868 AF077350 BM549522 AI936819 BE206066 BE858078 AW027314 
    AI290250 AB154416 BU628667 BF345645 BM913308 BX090708 CR592187 AI918307 
    AI364358 AI672457 BF953215 CR624931 CR619419 CR612752 BF953213 CR611538 

    GeneLoc Exon Structure

    Selected Alternative Splicing Database (ASD) splice patterns (SP) for AFMID (see all 10)    About this scheme

    ExUns: 1a · 1b ^ 2 ^ 3 ^ 4a · 4b · 4c ^ 5a · 5b ^ 6 ^ 7a · 7b · 7c ^ 8 ^ 9 ^ 10 ^ 11 ^ 12a · 12b · 12c · 12d · 12e
    SP1:                    -                             -                 -     -                                                         
    SP2:                    -                             -                                                                                 
    SP3:                                                  -     -           -     -     -     -     -                                       
    SP4:                    -                             -     -                                                                           
    SP5:                                                  -     -     -     -     -     -     -     -                                       


    ECgene alternative splicing isoforms for AFMID

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    AFMID expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: TTGATAAATA
    AFMID Expression
    About this image


    AFMID expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 3) fully expand
     
     Eye (Sensory Organs)
             Retina
     
     Liver (Hepatobiliary System)
     
     Kidney (Urinary System)
    AFMID Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    AFMID Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.558614
        Custom PCR Arrays for AFMID
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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for AFMID

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

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    This gene was present in the common ancestor of animals.

    Orthologs for AFMID gene from Selected species (see all 15)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Afmid1 , 5 arylformamidase1, 5 77.78(n)1
    72.39(a)1
      11 (82.96 cM)5
    715621  NM_027827.31  NP_082103.11 
     1178259245 
    chicken
    (Gallus gallus)
    Aves AFMID1 arylformamidase 64.42(n)
    56.03(a)
      769005  XM_004946295.1  XP_004946352.1 
    lizard
    (Anolis carolinensis)
    Reptilia AFMID6
    arylformamidase
    48(a)
    1 ↔ 1
    2(102282344-102286266)
    tropical clawed frog
    (Xenopus tropicalis)
    Amphibia afmid1 arylformamidase 58.3(n)
    46.44(a)
      100127853  NM_001113152.2  NP_001106623.1 
    zebrafish
    (Danio rerio)
    Actinopterygii LOC1005378941 kynurenine formamidase-like 58.36(n)
    48.44(a)
      100537894  XM_003199536.2  XP_003199584.2 
    fruit fly
    (Drosophila melanogaster)
    Insecta KFase1 Kynurenine formamidase 44.44(n)
    28.94(a)
      33907  NM_135192.2  NP_609036.1 
    worm
    (Caenorhabditis elegans)
    Secernentea D2024.21 D2024.2 44.9(n)
    33.47(a)
      177499  NM_068748.4  NP_501149.1 


    ENSEMBL Gene Tree for AFMID (if available)
    TreeFam Gene Tree for AFMID (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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      --

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for AFMID (see all 573)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 17 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1863317461,2
    --76185327(+) AGATGG/TAGTCT 3 -- int10--------
    rs1492398881,2
    --76185377(+) CAGCTC/TGCTGC 3 -- int10--------
    rs1912356511,2
    --76185550(+) TCACCC/TGCCTC 3 -- int10--------
    rs1816266831,2
    --76185551(+) CACCCA/GCCTCA 3 -- int10--------
    rs1859594521,2
    --76185595(+) CACCAC/TGCCCA 3 -- int10--------
    rs611721161,2
    C--76185609(+) TTTTT-/TGAAAC 3 -- int11Minor allele frequency- T:0.00CSA 2
    rs1127850481,2
    C,F--76185638(+) TTGCTC/TTCTCA 3 -- int11Minor allele frequency- T:0.50NA 2
    rs1446512021,2
    C--76185668(+) AATCTC/TGGCTC 3 -- int10--------
    rs288752571,2
    C,F--76185762(+) GCCCGG/CTTGAT 3 -- int11Minor allele frequency- C:0.10WA 118
    rs1490406751,2
    C--76185797(+) TGTTT-/CGCCAT 3 -- int10--------

    HapMap Linkage Disequilibrium report for AFMID (76183398 - 76203782 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 5 variations for AFMID:    About this table    
    Variant IDTypeSubtypePubMed ID
    dgv3277n71CNV Loss21882294
    dgv3279n71CNV Loss21882294
    dgv3278n71CNV Loss21882294
    nsv524306CNV Gain19592680
    nsv908876CNV Gain21882294

    Site Specific Mutation Identification with PCR Assays
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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    Find genes that share disorders with AFMID           About GenesLikeMe

    Human Genome Epidemiology (HuGE) Navigator: AFMID (1 document)

    Export disorders for AFMID gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for AFMID gene integrated from 10 sources:
    (articles sorted by number of sources associating them with AFMID)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Single nucleotide polymorphisms of matrix metalloproteinase 9 (MMP9) and tumor protein 73 (TP73) interact with Epstein-Barr virus in chronic lymphocytic leukemia: results from the European case-control study EpiLymph. (PubMed id 21048031)1 Casabonne D....de Sanjose S. (Haematologica 2011)
    2. Ubiquitin-mediated proteolysis of HuR by heat shock. (PubMed id 19322201)1 Abdelmohsen K....Gorospe M. (EMBO J. 2009)
    3. The full-ORF clone resource of the German cDNA consortium. (PubMed id 17974005)2 Bechtel S.... Schupp I. (BMC Genomics 2007)
    4. Enzymology of NAD+ homeostasis in man. (PubMed id 14704851)1 Magni G....Ruggieri S. (Cell. Mol. Life Sci. 2004)
    5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    6. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 125061 HGNC: 20910 AceView: BIRC5andAFMID Ensembl:ENSG00000183077 euGenes: HUgn125061
    ECgene: AFMID Kegg: 125061 H-InvDB: AFMID

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for AFMID Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for AFMID gene:
    Search GeneIP for patents involving AFMID

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, eBioscience, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
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