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Aliases for AFMID Gene

Aliases for AFMID Gene

  • Arylformamidase 2 3 4
  • N-Formylkynurenine Formamidase 3 4
  • KFase 3 4
  • FKF 3 4
  • KFA 3 4
  • Probable Arylformamidase 3
  • Kynurenine Formamidase 3
  • EC 3.5.1.9 4
  • KF 3

External Ids for AFMID Gene

Summaries for AFMID Gene

GeneCards Summary for AFMID Gene

AFMID (Arylformamidase) is a Protein Coding gene. Among its related pathways are Metabolism and Metabolism. GO annotations related to this gene include arylformamidase activity.

UniProtKB/Swiss-Prot for AFMID Gene

  • Catalyzes the hydrolysis of N-formyl-L-kynurenine to L-kynurenine, the second step in the kynurenine pathway of tryptophan degradation. Kynurenine may be further oxidized to nicotinic acid, NAD(H) and NADP(H). Required for elimination of toxic metabolites.

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for AFMID Gene

Genomics for AFMID Gene

Genomic Location for AFMID Gene

Start:
78,185,159 bp from pter
End:
78,207,701 bp from pter
Size:
22,543 bases
Orientation:
Plus strand

Genomic View for AFMID Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for AFMID Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for AFMID Gene

Regulatory Elements for AFMID Gene

Transcription factor binding sites by QIAGEN in the AFMID gene promoter:

Proteins for AFMID Gene

  • Protein details for AFMID Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q63HM1-KFA_HUMAN
    Recommended name:
    Kynurenine formamidase
    Protein Accession:
    Q63HM1
    Secondary Accessions:
    • A2RUB3

    Protein attributes for AFMID Gene

    Size:
    303 amino acids
    Molecular mass:
    33992 Da
    Quaternary structure:
    • Homodimer.

    Alternative splice isoforms for AFMID Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for AFMID Gene

Proteomics data for AFMID Gene at MOPED

Post-translational modifications for AFMID Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for AFMID Gene

Domains for AFMID Gene

Protein Domains for AFMID Gene

UniProtKB/Swiss-Prot:

KFA_HUMAN
Domain:
  • The main chain amide nitrogen atoms of the second glycine and its adjacent residue in the HGGXW motif define the oxyanion hole, and stabilize the oxyanion that forms during the nucleophilic attack by the catalytic serine during substrate cleavage.:
    • Q63HM1
Family:
  • Belongs to the kynurenine formamidase family.:
    • Q63HM1
genes like me logo Genes that share domains with AFMID: view

No data available for Gene Families for AFMID Gene

Function for AFMID Gene

Molecular function for AFMID Gene

UniProtKB/Swiss-Prot CatalyticActivity: N-formyl-L-kynurenine + H(2)O = formate + L-kynurenine.
UniProtKB/Swiss-Prot Function: Catalyzes the hydrolysis of N-formyl-L-kynurenine to L-kynurenine, the second step in the kynurenine pathway of tryptophan degradation. Kynurenine may be further oxidized to nicotinic acid, NAD(H) and NADP(H). Required for elimination of toxic metabolites.

Enzyme Numbers (IUBMB) for AFMID Gene

Gene Ontology (GO) - Molecular Function for AFMID Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004061 arylformamidase activity IEA --
GO:0016787 hydrolase activity --
genes like me logo Genes that share ontologies with AFMID: view

Phenotypes for AFMID Gene

MGI mutant phenotypes for AFMID:
inferred from 1 alleles
genes like me logo Genes that share phenotypes with AFMID: view

Animal Models for AFMID Gene

MGI Knock Outs for AFMID:

No data available for miRNA , Transcription Factor Targeting and HOMER Transcription for AFMID Gene

Localization for AFMID Gene

Subcellular locations from UniProtKB/Swiss-Prot for AFMID Gene

Cytoplasm, cytosol. Nucleus. Note=Predominantly cytosolic. Some fraction is nuclear. {ECO:0000255 HAMAP-Rule:MF_03014}.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for AFMID Gene COMPARTMENTS Subcellular localization image for AFMID gene
Compartment Confidence
cytosol 2
nucleus 2
mitochondrion 1
peroxisome 1

Gene Ontology (GO) - Cellular Components for AFMID Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IEA --
GO:0005737 cytoplasm --
GO:0005829 cytosol IEA --
genes like me logo Genes that share ontologies with AFMID: view

Pathways for AFMID Gene

genes like me logo Genes that share pathways with AFMID: view

Pathways by source for AFMID Gene

UniProtKB/Swiss-Prot Q63HM1-KFA_HUMAN

  • Pathway: Amino-acid degradation; L-tryptophan degradation via kynurenine pathway; L-kynurenine from L-tryptophan: step 2/2.

Interacting Proteins for AFMID Gene

Gene Ontology (GO) - Biological Process for AFMID Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006569 tryptophan catabolic process TAS --
GO:0008152 metabolic process --
GO:0019441 tryptophan catabolic process to kynurenine IEA --
GO:0034354 de novo NAD biosynthetic process from tryptophan IEA --
GO:0034641 cellular nitrogen compound metabolic process TAS --
genes like me logo Genes that share ontologies with AFMID: view

Compounds for AFMID Gene

(11) HMDB Compounds for AFMID Gene

Compound Synonyms Cas Number PubMed IDs
2-Aminobenzoic acid
  • 1-Amino-2-carboxybenzene
118-92-3
5-Hydroxykynurenine
  • 5-Hydroxy-L-kynurenine
2208-41-5
5-Hydroxy-N-formylkynurenine
Not Available
Formic acid
  • Add-F
64-18-6
Formylanthranilic acid
  • 2-(Formylamino)-benzoic acid
3342-77-6
genes like me logo Genes that share compounds with AFMID: view

Transcripts for AFMID Gene

Unigene Clusters for AFMID Gene

Arylformamidase:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for AFMID Gene

ExUns: 1a · 1b ^ 2 ^ 3 ^ 4a · 4b · 4c ^ 5a · 5b ^ 6 ^ 7a · 7b · 7c ^ 8 ^ 9 ^ 10 ^ 11 ^ 12a · 12b · 12c · 12d · 12e
SP1: - - - -
SP2: - -
SP3: - - - - - - -
SP4: - - -
SP5: - - - - - - - -
SP6: -
SP7: - - - - - - - - - - - - -
SP8: - - - - - - - - - -
SP9:
SP10: - - - - - - - - - - - - - -

Relevant External Links for AFMID Gene

GeneLoc Exon Structure for
AFMID
ECgene alternative splicing isoforms for
AFMID

Expression for AFMID Gene

mRNA expression in normal human tissues for AFMID Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for AFMID Gene

This gene is overexpressed in Liver (8.0).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for AFMID Gene

SOURCE GeneReport for Unigene cluster for AFMID Gene Hs.558614

genes like me logo Genes that share expressions with AFMID: view

Orthologs for AFMID Gene

This gene was present in the common ancestor of animals.

Orthologs for AFMID Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia AFMID 36
  • 99.34 (n)
  • 99.01 (a)
AFMID 37
  • 99 (a)
OneToOne
cow
(Bos Taurus)
Mammalia AFMID 36
  • 83.11 (n)
  • 78.81 (a)
AFMID 37
  • 77 (a)
OneToOne
dog
(Canis familiaris)
Mammalia AFMID 36
  • 83.68 (n)
  • 79.31 (a)
AFMID 37
  • 74 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Afmid 36
  • 77.78 (n)
  • 72.39 (a)
Afmid 16
Afmid 37
  • 68 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia AFMID 37
  • 34 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia -- 37
  • 43 (a)
OneToMany
-- 37
  • 45 (a)
OneToMany
rat
(Rattus norvegicus)
Mammalia Afmid 36
  • 76.76 (n)
  • 69.05 (a)
chicken
(Gallus gallus)
Aves AFMID 36
  • 64.42 (n)
  • 56.03 (a)
AFMID 37
  • 55 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia AFMID 37
  • 48 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia afmid 36
  • 58.3 (n)
  • 46.44 (a)
zebrafish
(Danio rerio)
Actinopterygii afmid 37
  • 48 (a)
OneToMany
CU929356.4 37
  • 47 (a)
OneToMany
LOC100537894 36
  • 58.36 (n)
  • 48.44 (a)
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP009433 36
  • 46.62 (n)
  • 35.14 (a)
fruit fly
(Drosophila melanogaster)
Insecta CG9542 37
  • 24 (a)
OneToOne
KFase 36
  • 44.44 (n)
  • 28.94 (a)
worm
(Caenorhabditis elegans)
Secernentea afmd-1 37
  • 29 (a)
OneToMany
D2024.2 36
  • 44.9 (n)
  • 33.47 (a)
Y45F10A.3 37
  • 25 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea -- 37
  • 26 (a)
OneToMany
-- 37
  • 26 (a)
OneToMany
Species with no ortholog for AFMID:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for AFMID Gene

ENSEMBL:
Gene Tree for AFMID (if available)
TreeFam:
Gene Tree for AFMID (if available)

Paralogs for AFMID Gene

No data available for Paralogs for AFMID Gene

Variants for AFMID Gene

Sequence variations from dbSNP and Humsavar for AFMID Gene

SNP ID Clin Chr 17 pos Sequence Context AA Info Type MAF
rs1079133 -- 78,199,702(-) TGGTG(A/G)CCACA intron-variant
rs2009106 -- 78,199,663(-) GGGCG(C/G)GGCGG intron-variant
rs4340385 -- 78,202,022(+) ACTGC(A/G)CCCAG intron-variant
rs4341803 -- 78,199,146(+) GCGTT(C/G)TGCAA intron-variant
rs4402626 -- 78,194,359(+) GCCTC(A/G)AGTGA intron-variant

Structural Variations from Database of Genomic Variants (DGV) for AFMID Gene

Variant ID Type Subtype PubMed ID
dgv3277n71 CNV Loss 21882294
dgv3278n71 CNV Loss 21882294
dgv3279n71 CNV Loss 21882294
nsv524306 CNV Gain 19592680
nsv908876 CNV Gain 21882294

Relevant External Links for AFMID Gene

HapMap Linkage Disequilibrium report
AFMID

Disorders for AFMID Gene

Relevant External Links for AFMID

Human Genome Epidemiology (HuGE) Navigator
AFMID
genes like me logo Genes that share disorders with AFMID: view

No data available for UniProtKB/Swiss-Prot for AFMID Gene

Publications for AFMID Gene

  1. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg R.L. … Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002) 3
  2. Enzymology of NAD+ homeostasis in man. (PMID: 14704851) Magni G. … Ruggieri S. (Cell. Mol. Life Sci. 2004) 3
  3. Ubiquitin-mediated proteolysis of HuR by heat shock. (PMID: 19322201) Abdelmohsen K. … Gorospe M. (EMBO J. 2009) 3
  4. Single nucleotide polymorphisms of matrix metalloproteinase 9 (MMP9) and tumor protein 73 (TP73) interact with Epstein-Barr virus in chronic lymphocytic leukemia: results from the European case-control study EpiLymph. (PMID: 21048031) Casabonne D. … de Sanjose S. (Haematologica 2011) 3
  5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 4

Products for AFMID Gene

Sources for AFMID Gene

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