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Aliases for AFM Gene

Aliases for AFM Gene

  • Afamin 2 3
  • ALB2 3 4 6
  • ALBA 3 4 6
  • Alpha-Albumin 3 4
  • Alpha-Alb 3 4
  • ALF 3

External Ids for AFM Gene

Previous GeneCards Identifiers for AFM Gene

  • GC04P074336
  • GC04P074587
  • GC04P074748
  • GC04P074813
  • GC04P074712
  • GC04P074566
  • GC04P070158

Summaries for AFM Gene

Entrez Gene Summary for AFM Gene

  • This gene is a member of the albumin gene family, which is comprised of four genes that localize to chromosome 4 in a tandem arrangement. These four genes encode structurally-related serum transport proteins that are known to be evolutionarily related. The protein encoded by this gene is regulated developmentally, expressed in the liver and secreted into the bloodstream. [provided by RefSeq, Jul 2008]

GeneCards Summary for AFM Gene

AFM (Afamin) is a Protein Coding gene. Diseases associated with AFM include squamous papillomatosis and trigonitis. GO annotations related to this gene include vitamin E binding. An important paralog of this gene is AFP.

UniProtKB/Swiss-Prot for AFM Gene

  • Vitamin E binding protein. May transport vitamin E in body fluids under conditions where the lipoprotein system is not sufficient. May be involved in the regulation and transport of vitamin E at the blood-brain barrier.

Gene Wiki entry for AFM Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for AFM Gene

Genomics for AFM Gene

Regulatory Elements for AFM Gene

Genomic Location for AFM Gene

Start:
73,481,683 bp from pter
End:
73,504,001 bp from pter
Size:
22,319 bases
Orientation:
Plus strand

Genomic View for AFM Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for AFM Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for AFM Gene

Proteins for AFM Gene

  • Protein details for AFM Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P43652-AFAM_HUMAN
    Recommended name:
    Afamin
    Protein Accession:
    P43652
    Secondary Accessions:
    • A8K3E1
    • Q32MR3
    • Q4W5C5

    Protein attributes for AFM Gene

    Size:
    599 amino acids
    Molecular mass:
    69069 Da
    Quaternary structure:
    No Data Available

neXtProt entry for AFM Gene

Proteomics data for AFM Gene at MOPED

Post-translational modifications for AFM Gene

  • N-glycosylated; more than 90% of the glycans are sialylated.
  • Glycosylation at Asn33, Asn109, Asn383, Asn402, and Asn488
  • Modification sites at PhosphoSitePlus

Other Protein References for AFM Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for AFM Gene

Domains for AFM Gene

Suggested Antigen Peptide Sequences for AFM Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

P43652

UniProtKB/Swiss-Prot:

AFAM_HUMAN :
  • P43652
Domain:
  • Contains 3 albumin domains.
Family:
  • Belongs to the ALB/AFP/VDB family.
genes like me logo Genes that share domains with AFM: view

No data available for Gene Families for AFM Gene

Function for AFM Gene

Molecular function for AFM Gene

GENATLAS Biochemistry: afamin,87kDa,albumin superfamily
UniProtKB/Swiss-Prot Function: Vitamin E binding protein. May transport vitamin E in body fluids under conditions where the lipoprotein system is not sufficient. May be involved in the regulation and transport of vitamin E at the blood-brain barrier.

Gene Ontology (GO) - Molecular Function for AFM Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0008431 vitamin E binding IDA 15952736
genes like me logo Genes that share ontologies with AFM: view

Phenotypes for AFM Gene

genes like me logo Genes that share phenotypes with AFM: view

Animal Model Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for AFM

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Animal Models , miRNA , Transcription Factor Targeting and HOMER Transcription for AFM Gene

Localization for AFM Gene

Subcellular locations from UniProtKB/Swiss-Prot for AFM Gene

Secreted.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for AFM Gene COMPARTMENTS Subcellular localization image for AFM gene
Compartment Confidence
extracellular 5
cytoskeleton 1
cytosol 1
golgi apparatus 1
peroxisome 1

Gene Ontology (GO) - Cellular Components for AFM Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005576 extracellular region TAS 7517938
GO:0005615 extracellular space IDA 15952736
GO:0070062 extracellular exosome IDA 23376485
GO:0072562 blood microparticle IDA 22516433
genes like me logo Genes that share ontologies with AFM: view

Pathways for AFM Gene

SuperPathways for AFM Gene

No Data Available

Interacting Proteins for AFM Gene

STRING Interaction Network Preview (showing 1 interactants - click image to see details)
http://string-db.org/version_10/api/image/networkList?limit=0&targetmode=proteins&caller_identity=gene_cards&network_flavor=evidence&identifiers=9606.ENSP00000226355%0d%0a9606.ENSP00000328287%0d%0a
Selected Interacting proteins: ENSP00000226355 for AFM Gene via STRING

Symbol External ID(s) Details
RNF123

Gene Ontology (GO) - Biological Process for AFM Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0051180 vitamin transport IDA 19046407
genes like me logo Genes that share ontologies with AFM: view

No data available for Pathways by source for AFM Gene

Compounds for AFM Gene

(3) Novoseek inferred chemical compound relationships for AFM Gene

Compound -log(P) Hits PubMed IDs
vitamin-e 61.8 9
vitamin d 52.1 5
alpha tocopherol 50.4 6
genes like me logo Genes that share compounds with AFM: view

Transcripts for AFM Gene

mRNA/cDNA for AFM Gene

(31) Selected AceView cDNA sequences:
(1) REFSEQ mRNAs :
(4) Additional mRNA sequences :
(2) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for AFM Gene

Afamin:
Representative Sequences:

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for AFM

Primer Products

  • OriGene qSTAR qPCR primer pairs in human,mouse,rat for AFM

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for AFM Gene

ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10a · 10b ^ 11a · 11b ^ 12a · 12b ^ 13a · 13b ^ 14 ^ 15 ^ 16
SP1: - -
SP2:
SP3:
SP4: -

Relevant External Links for AFM Gene

GeneLoc Exon Structure for
AFM
ECgene alternative splicing isoforms for
AFM

Expression for AFM Gene

mRNA expression in normal human tissues for AFM Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for AFM Gene

This gene is overexpressed in Liver (50.8).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, and MOPED for AFM Gene

SOURCE GeneReport for Unigene cluster for AFM Gene Hs.168718

mRNA Expression by UniProt/SwissProt for AFM Gene

P43652-AFAM_HUMAN
Tissue specificity: High level detected in plasma but also in extravascular fluids such as follicular and cerebrospinal fluids (at protein level).
genes like me logo Genes that share expressions with AFM: view

In Situ Assay Products

Orthologs for AFM Gene

This gene was present in the common ancestor of chordates.

Orthologs for AFM Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia AFM 35
  • 99.44 (n)
  • 99 (a)
AFM 36
  • 99 (a)
OneToOne
cow
(Bos Taurus)
Mammalia AFM 35
  • 83.89 (n)
  • 75.59 (a)
AFM 36
  • 75 (a)
OneToOne
dog
(Canis familiaris)
Mammalia AFM 35
  • 82.75 (n)
  • 75.21 (a)
AFM 36
  • 74 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Afm 35
  • 76.96 (n)
  • 67.78 (a)
Afm 16
Afm 36
  • 67 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia AFM 36
  • 46 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia -- 36
  • 40 (a)
OneToMany
-- 36
  • 38 (a)
OneToMany
rat
(Rattus norvegicus)
Mammalia Afm 35
  • 76.74 (n)
  • 67.95 (a)
chicken
(Gallus gallus)
Aves -- 36
  • 34 (a)
OneToMany
lizard
(Anolis carolinensis)
Reptilia -- 36
  • 32 (a)
ManyToMany
-- 36
  • 33 (a)
ManyToMany
Species with no ortholog for AFM:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for AFM Gene

ENSEMBL:
Gene Tree for AFM (if available)
TreeFam:
Gene Tree for AFM (if available)

Paralogs for AFM Gene

Paralogs for AFM Gene

Selected SIMAP similar genes for AFM Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with AFM: view

Variants for AFM Gene

Sequence variations from dbSNP and Humsavar for AFM Gene

SNP ID Clin Chr 04 pos Sequence Context AA Info Type MAF
rs1158101 -- 73,497,565(+) AGAAA(C/T)AAGAA intron-variant
rs1159624 -- 73,501,989(+) CCCTG(C/T)AGGAC intron-variant, downstream-variant-500B
rs1894292 -- 73,483,441(+) TTAGT(A/G)TATGC intron-variant
rs1894293 -- 73,486,305(+) TAATT(A/G)GTAAG intron-variant
rs2040354 -- 73,501,383(+) TTGTA(C/T)TGGGA intron-variant

Relevant External Links for AFM Gene

HapMap Linkage Disequilibrium report
AFM

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Structural Variations from Database of Genomic Variants (DGV) for AFM Gene

Disorders for AFM Gene

MalaCards: The human disease database

MalaCards: The human disease database. (2) Diseases for AFM Gene including...

Search for AFM Gene in MalaCards »

(2) University of Copenhagen DISEASES for AFM Gene

Relevant External Links for AFM

Genetic Association Database (GAD)
AFM
genes like me logo Genes that share disorders with AFM: view

No data available for UniProtKB/Swiss-Prot for AFM Gene

Publications for AFM Gene

  1. Afamin is a new member of the albumin, alpha-fetoprotein, and vitamin D-binding protein gene family. (PMID: 7517938) Lichenstein H.S. … Zukowski M.M. (J. Biol. Chem. 1994) 2 3 4 23
  2. Identification of rat alpha-albumin and cDNA cloning of its human ortholog. (PMID: 7875606) Allard D. … Belanger L. (Gene 1995) 3 4 23
  3. Complete structure of the human alpha-albumin gene, a new member of the serum albumin multigene family. (PMID: 8755513) Nishio H. … Dugaiczyk A. (Proc. Natl. Acad. Sci. U.S.A. 1996) 3 4 23
  4. Characterization of the vitamin E-binding properties of human plasma afamin. (PMID: 12463752) Voegele A.F. … Dieplinger H. (Biochemistry 2002) 3 4 23
  5. Afamin is a novel human vitamin E-binding glycoprotein characterization and in vitro expression. (PMID: 15952736) Jerkovic L. … Dieplinger H. (J. Proteome Res. 2005) 3 4 23

Products for AFM Gene

Sources for AFM Gene

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