AFF4 Gene
protein-coding GIFtS: 49
GCID: GC05M132211
|
|
AF4/FMR2 family, member 4
| |
Aliases
for AFF4 gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| AF4/FMR2 Family, Member 41 2 | | ALL1-Fused Gene From Chromosome 5q31 Protein2 3 | | AF5Q311 2 3 5 | | AF4/FMR2 Family Member 42 | | MCEF1 2 3 | | Protein AF-5q313 | | Major CDK9 Elongation Factor-Associated Protein2 3 | | |
Export aliases for AFF4 gene to outside databasesPrevious GC identifers: GC05M132243 GC05M127403 |
Summaries
for AFF4 gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
Entrez Gene summary for AFF4:
The protein encoded by this gene belongs to the AF4 family of transcription factors involved in leukemia. It is acomponent of the positive transcription elongation factor b (P-TEFb) complex. A chromosomal translocation involvingthis gene and MLL gene on chromosome 11 is found in infant acute lymphoblastic leukemia with ins(5;11)(q31;q31q23).(provided by RefSeq, Oct 2011)
UniProtKB/Swiss-Prot: AFF4_HUMAN, Q9UHB7Function: Key component of the super elongation complex (SEC), a complex required to increase the catalytic rate of RNApolymerase II transcription by suppressing transient pausing by the polymerase at multiple sites along the DNA. In theSEC complex, AFF4 acts as a central scaffold that recruits other factors through direct interactions with ELL proteins(ELL, ELL2 or ELL3) and the P-TEFb complex. In case of infection by HIV-1 virus, the SEC complex is recruited by theviral Tat protein to stimulate viral gene expression
|
Genomic Views
for AFF4 gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000005.9 NC_018916.1 NT_034772.6
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the AFF4 gene promoter:
HOXA9B HOXA9 c-Fos RFX1 AP-1 Nkx2-5 HNF-3beta Arnt c-Jun Meis-1
Other transcription factors
Search SABiosciences Chromatin IP Primers for AFF4
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat AFF4 |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 5q31 Ensembl cytogenetic band: 5q31.1 HGNC cytogenetic band: 5q31AFF4 Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 5 GeneLoc Exon Structure GeneLoc location for GC05M132211: view genomic region
(about GC identifiers)
Start:
|
132,211,071 bp from pter |
End:
|
132,299,354 bp from pter |
Size:
|
88,284 bases |
Orientation:
|
minus strand |
|
Proteins
for AFF4 gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: AFF4_HUMAN, Q9UHB7 (See
protein sequence)Recommended Name: AF4/FMR2 family member 4 Size: 1163 amino acids; 127459 Da
Subunit: Interacts with ELL3; the interaction is direct (By similarity). Interacts with ELL2; the interaction is directand leads to stabilize ELL2 and prevent ELL2 ubiquitination and degradation. Component of the super elongation complex(SEC), at least composed of EAF1, MLLT3/AF9, AFF (AFF1 or AFF4), the P-TEFb complex and ELL (ELL, ELL2 or ELL3).Interacts with ELL
Subcellular location: Nucleus
Developmental stage: Expressed in fetal heart, lung, brain and to a lower extent liver
Sequence caution: Sequence=AAI00288.1; Type=Miscellaneous discrepancy; Note=Contaminating sequence. Potential poly-Asequence; Sequence=BAD92784.1; Type=Erroneous initiation;
Secondary accessions: B2RP19 B7WPD2 Q498B2 Q59FB3 Q6P592 Q8TDR1 Q9P0E4Alternative splicing: 3 isoforms: Q9UHB7-1 Q9UHB7-2 Q9UHB7-3 Explore the universe of human proteins at neXtProt for AFF4: NX_Q9UHB7
Post-translational modifications:
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_Q9UHB7
AFF4 Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins: NP_055238.1
ENSEMBL proteins: ENSP00000265343 ENSP00000367858 ENSP00000409069 ENSP00000395268
Human Recombinant Protein Products:
Gene Ontology (GO): 3 cellular component terms (GO ID links to tree view): About this table
AFF4 for ontologies About GeneDecksing
AFF4 Antibody Products:
Assay Products for AFF4: |
Protein
Domains /
Families
for AFF4 gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
AFF4 for domains About GeneDecksing
1 InterPro domain/family:Graphical View of Domain Structure for InterPro Entry Q9UHB7ProtoNet protein and cluster: Q9UHB7 1 Blocks protein family: IPB007797 AF-4 proto-oncoprotein
UniProtKB/Swiss-Prot: AFF4_HUMAN, Q9UHB7Similarity: Belongs to the AF4 family |
Function
for AFF4 gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Function Summary:
UniProtKB/Swiss-Prot: AFF4_HUMAN, Q9UHB7Function: Key component of the super elongation complex (SEC), a complex required to increase the catalytic rate of RNApolymerase II transcription by suppressing transient pausing by the polymerase at multiple sites along the DNA. In theSEC complex, AFF4 acts as a central scaffold that recruits other factors through direct interactions with ELL proteins(ELL, ELL2 or ELL3) and the P-TEFb complex. In case of infection by HIV-1 virus, the SEC complex is recruited by theviral Tat protein to stimulate viral gene expression
Clone
Products: |  | Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore | |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for AFF4 (see all 3)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for AFF4
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling 
| |  | GenScript: all cDNA clones in your preferred vector: AFF4 (NM_014423) | |  | Browse Sino Biological Human cDNA Clones | |  | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for AFF4 | |  | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat AFF4 |
In Situ Assay
Products: |
 | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for AFF4 |
Gene Ontology (GO): 2 molecular function terms (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0003700 | sequence-specific DNA binding transcription factor activity |
TAS | 10588740 | | GO:0005515 | protein binding |
IPI | -- |
AFF4 for ontologies About GeneDecksing
Animal Models:
Mouse knock-out Aff4tm1Nosa for AFF4
8 MGI mutant phenotypes (inferred from 1 allele ) (MGI details for Aff4):
AFF4 for phenotypes About GeneDecksing
|
Pathways & Interactions
for AFF4 gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Interactions:
Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for AFF4
STRING Interaction
Network Preview (showing 5 interactants - click image to see 20)
5/23 Interacting proteins for AFF4 (Q9UHB71, 2, 3 ENSP000002653434) via UniProtKB, MINT, STRING, and/or I2D (see all 23)| Interactant | Interaction Details |
|---|
| GeneCard | External ID(s) |
|---|
| SIAH1 | Q8IUQ42, 3, ENSP000003491564 | MINT-66990 I2D:
score=4 STRING: ENSP00000349156 | | CCNT1 | O605631, 3, ENSP000002619004 | EBI-1384303,EBI-2479671 I2D:
score=3 STRING: ENSP00000261900 | | MLLT3 | P425681, 3, ENSP000003696954 | EBI-1384303,EBI-716132 I2D:
score=2 STRING: ENSP00000369695 | | MLLT1 | Q031111, 3, ENSP000002526744 | EBI-1384303,EBI-1384215 I2D:
score=4 STRING: ENSP00000252674 | | MED10 | Q9BTT43, ENSP000002557644 | I2D:
score=1 STRING: ENSP00000255764 |
About this table
Gene Ontology (GO): 3 biological process terms (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0006355 | regulation of transcription, DNA-dependent |
-- | -- | | GO:0006366 | transcription from RNA polymerase II promoter |
TAS | 10588740 | | GO:0007286 | spermatid development |
IEA | -- |
AFF4 for ontologies About GeneDecksing
|
Drugs & Compounds
for AFF4 gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
 Browse Tocris compounds for AFF4
Search CenterWatch for drugs/clinical trials and news about AFF4
|
Transcripts
for AFF4 gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for AFF4 gene: NM_014423.3 Unigene Cluster for AFF4: AF4/FMR2 family, member 4 Hs.519313 [show with all ESTs]Unigene Representative Sequence: NM_0144239 Ensembl transcripts including schematic representations, and UCSC links where relevant: ENST00000265343(uc003kyd.3 uc011cxk.2) ENST00000378595(uc003kye.1)
ENST00000478588 ENST00000378593 ENST00000425658 ENST00000477369 ENST00000491831
ENST00000465484(uc003kyf.4) ENST00000421773
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for AFF4 (see all 3)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for AFF4
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript: all cDNA clones in your preferred vector: AFF4 (NM_014423) | | | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for AFF4 | | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat AFF4 |
Additional cDNA sequence: AB209547.1 AF161355.1 AF173886.1 AF197927.1 AF213987.2 AK024831.1 AK055638.1 AK126818.1 AK307407.1 BC025700.1 BC063007.1 BC100287.1 BC137226.1 BC144538.1 21 DOTS entries: DT.106700 DT.435243 DT.110034 DT.91746494 DT.97858702 DT.91946025 DT.95207548 DT.40249939 DT.40260120 DT.120803242 DT.91746492 DT.95366815 DT.120803256 DT.430967 DT.91651639 DT.95248796 DT.100749401 DT.101976043 DT.40112133 DT.91660210 DT.97772394 24/238 AceView cDNA sequences (see all 238): AI949293 AL044396 BP350261 AI914070 AF173886 BC040454 BQ438036 BQ708661 BM449518 BG288429 CN478659 BP343784 BE328052 BQ722836 AK126818 NM_014423 BM836800 BM835510 BX503945 BU074576 AI672170 BM718613 AF197927 BU743052
GeneLoc Exon Structure
5 Alternative Splicing Database (ASD) splice patterns (SP) for AFF4 About this scheme
| ExUns: | 1a | · | 1b | · | 1c | · | 1d | ^ | 2 | ^ | 3 | ^ | 4a | · | 4b | ^ | 5 | ^ | 6a | · | 6b | ^ | 7 | ^ | 8 | ^ | 9 | ^ | 10 | ^ | 11 | ^ | 12 | ^ | 13a | · | 13b | ^ | 14 | ^ | 15a | · | 15b | ^ | 16 | ^ | 17 | ^ | 18 | ^ | 19 | ^ |
|---|
|
| SP1: | | | | | | | | | - | | | | | | | | | | | | - | | | | | | - | | | | | | | | | | | | | | | | - | | | | | | | | | | |
| SP2: | | | | | | | | | - | | | | | | | | | | | | - | | | | | | - | | | | | | | | | | | | | | | | | | | | | | | | | | |
| SP3: | | | | | | | | | - | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | |
| SP4: | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | |
| SP5: | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | |
| ExUns: | 20 | ^ | 21 | ^ | 22 | ^ | 23 |
|---|
|
| SP1: | | | | | | | | | |
| SP2: | | | | | | | | | |
| SP3: | | | | | | | | | |
| SP4: | | | | | | | | | |
| SP5: | | | | | | | | |
ECgene alternative splicing isoforms for AFF4
|
Expression
for AFF4 gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| AFF4 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: CGTTTAATGT
About this image
See AFF4 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for AFF4
SOURCE GeneReport for Unigene cluster: Hs.519313
UniProtKB/Swiss-Prot: AFF4_HUMAN, Q9UHB7Tissue specificity: Ubiquitously expressed. Strongly expressed in heart, placenta, skeletal muscle, pancreas and to alower extent in brain
SABiosciences Custom PCR Arrays for AFF4
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for AFF4
Browse OriGene validated miRNA SYBR primer pairs
| | | SABiosciences RT2 qPCR Primer Assay in human, mouse, rat AFF4 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat AFF4 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat AFF4 | In Situ
Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for AFF4 |
Orthologs
for AFF4 gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
This gene was present in the common ancestor of animals.
Orthologs for AFF4 gene from 5/15 species (see all 15) About this table
ENSEMBL Gene Tree for AFF4 (if available)
TreeFam Gene Tree for AFF4 (if available) |
Paralogs
for AFF4 gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| Paralogs for AFF4 gene
- AFF32 AFF12 AFF22
4 SIMAP similar genes for AFF4 using alignment to 5 protein entries: AFF4_HUMAN (see all proteins):AFF3 AFF1 AF-4 AFF2
AFF4 for paralogs About GeneDecksing
1 Pseudogenes.org Pseudogene for AFF4
PGOHUM00000238196
|
Genomic Variants
for AFF4 gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr 5 pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
|---|
HapMap Linkage Disequilibrium report for AFF4 (132211071 - 132299354 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV) variations for AFF4: -- | SABiosciences Cancer Mutation PCR Assays |
| | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing AFF4 |
|
Disorders
/ Diseases
for AFF4 gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
AFF4 for disorders About GeneDecksing
OMIM gene information: 604417
OMIM disorders: --
UniProtKB/Swiss-Prot: AFF4_HUMAN, Q9UHB7
Note=A chromosomal aberration involving AFF4 is found in acute lymphoblastic leukemia (ALL). Insertionins(5;11)(q31;q13q23) that forms a MLL-AFF4 fusion protein
3  diseases for AFF4: About MalaCardsacute lymphoblastic leukemia lymphoblastic leukemia leukemia
Human Genome Epidemiology (HuGE) Navigator: AFF4 (1 document)
Export disorders for AFF4 gene to outside databases
|
Publications
for AFF4 gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for AFF4 gene, integrated from 9 sources (see all 50):
(articles sorted by number of sources associating them with AFF4) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- AF5q31, a newly identified AF4-related gene, is fused to MLL in infant acute lymphoblastic leukemia with ins(5;11)(q31;q13q23). (PubMed id 10588740)1, 2, 3, 9 Taki T.... Hayashi Y. (1999)
- The ubiquitin ligase Siah1 controls ELL2 stability and formation of super elongation complexes to modulate gene transcription. (PubMed id 22483617)1, 2 Liu M....Zhou Q. (2012)
- HIV-1 Tat and host AFF4 recruit two transcription elo ngation factors into a bifunctional complex for coordinated activation of HIV-1 transcription. (PubMed id 20471948)1, 2 He N....Zhou Q. (2010)
- AFF4, a component of the ELL/P-TEFb elongation comple x and a shared subunit of MLL chimeras, can link transcription elongation to le ukemia. (PubMed id 20159561)1, 2 Lin C....Shilatifard A. (2010)
- Global, in vivo, and site-specific phosphorylation dynamics in signaling networks. (PubMed id 17081983)1, 2 Olsen J.V....Mann M. (2006)
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
- MCEF, the newest member of the AF4 family of transcription factors involved in leukemia, is a positive transcription elongation factor-b- associated protein. (PubMed id 12065898)1, 2 Estable M.C....Roeder R.G. (2002)
- MCEF is localized to the nucleus by protein sequences encoded within three distinct exons, where it represses HIV-1 Tat-transactivation of LTR-directed transcription. (PubMed id 17389929)1, 9 Niedzielski M.F....Estable M.C. (2007)
- HIV-1 Tat recruits transcription elongation factors dispersed along a flexible AFF4 scaffold. (PubMed id 23251033)2 Chou S.... Alber T. (2013)
- Targeted ubiquitination and degradation of G-protein-c oupled receptor kinase 5 by the DDB1-CUL4 ubiquitin ligase complex. (PubMed id 22952844)1 Wu Z....Ma L. (2012)
|
External Searches for AFF4 gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
|
|
Genome Databases showing AFF4 gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing AFF4 gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing AFF4 gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
|
About This Section
| Patent Information for AFF4 gene:
Search GeneIP for patents involving AFF4
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for AFF4 gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences),
In Situ Hybridization Assays from
Advanced Cell Diagnostics
About This Section
|
 | |
 | |
 |
| | |  | Browse OriGene Antibodies | | OriGene shRNA RFP for AFF4 | | | OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for AFF4 | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for AFF4 | | | OriGene Protein Over-expression Lysate for AFF4 | | Browse OriGene Fluorogenic Cell Assay Kits | | | OriGene siRNA for AFF4 | | OriGene 3'-UTR Clone for AFF4 | | | OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for AFF4 | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for AFF4 | | | Browse OriGene GFP tagged cDNA clones in CMV expression vector | | Browse OriGene MicroRNA Expression Plasmids | | | Browse OriGene basic RS shRNAs | | Browse OriGene validated miRNA SYBR primer pairs | | | Browse OriGene full length recombinant human proteins expressed in human HEK293 cells | | OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling | | | OriGene Custom Antibody Services for AFF4 | | OriGene Custom Protein Services for AFF4 | | | OriGene Custom Immunoassay Development | | |
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| | | QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat AFF4 | | | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing AFF4 | | | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat AFF4 | | | QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat AFF4 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat AFF4 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat AFF4 |
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| | | | Search Tocris compounds for AFF4 |
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 | | | AFF4 Proteins, Antibodies, CLIAs, and ELISAs |
| | | | | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for AFF4 |
|  |  |  | | | | ThermoFisher Antibodies for AFF4 |
| | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat AFF4 |
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