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AFF3 Gene

protein-coding   GIFtS: 54
GCID: GC02M100163

AF4/FMR2 Family, Member 3

(Previous name: lymphoid nuclear protein related to AF4)
(Previous symbol: LAF4)
  See AFF3-related disease
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
AF4/FMR2 Family, Member 31 2     MLLT2-like2
LAF41 2 3 5     AF4/FMR2 Family Member 32
Lymphoid Nuclear Protein Related To AF41 2 3     Lymphoid Nuclear Protein 42
Protein LAF-42 3     MLLT2-Related Protein2

External Ids:    HGNC: 64731   Entrez Gene: 38992   Ensembl: ENSG000001442187   OMIM: 6014645   UniProtKB: P518263   

Export aliases for AFF3 gene to outside databases

Previous GC identifers: GC02M099627 GC02M093928


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for AFF3 Gene:
This gene encodes a tissue-restricted nuclear transcriptional activator that is preferentially expressed in
lymphoid tissue. Isolation of this protein initially defined a highly conserved LAF4/MLLT2 gene family of nuclear
transcription factors that may function in lymphoid development and oncogenesis. In some ALL patients, this gene
has been found fused to the gene for MLL. Multiple alternatively spliced transcript variants that encode
different proteins have been found for this gene. (provided by RefSeq, Jul 2008)

GeneCards Summary for AFF3 Gene:
AFF3 (AF4/FMR2 family, member 3) is a protein-coding gene. Diseases associated with AFF3 include fibular aplasia. GO annotations related to this gene include double-stranded DNA binding. An important paralog of this gene is AFF1.

UniProtKB/Swiss-Prot: AFF3_HUMAN, P51826
Function: Putative transcription activator that may function in lymphoid development and oncogenesis. Binds, in
vitro, to double-stranded DNA

Gene Wiki entry for AFF3 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000002.11  NT_005403.18  NC_018913.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the AFF3 gene promoter:
         AML1a   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmids (see all 2): AFF3 promoter sequence
   Search Chromatin IP Primers for AFF3

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat AFF3


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 2q11.2-q12   Ensembl cytogenetic band:  2q11.2   HGNC cytogenetic band: 2q11.2-q12

AFF3 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
AFF3 gene location

GeneLoc information about chromosome 2         GeneLoc Exon Structure

GeneLoc location for GC02M100163:  view genomic region     (about GC identifiers)

Start:
100,162,323 bp from pter      End:
100,759,201 bp from pter
Size:
596,879 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., and/or eBioscience,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., and/or eBioscience, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: AFF3_HUMAN, P51826 (See protein sequence)
Recommended Name: AF4/FMR2 family member 3  
Size: 1226 amino acids; 133476 Da
Secondary accessions: B7ZM46 B9EGL9 D3DVI6 Q53RD6 Q53S47 Q53SI6 Q53TB9 Q59F27 Q8IWJ5
Alternative splicing: 2 isoforms:  P51826-1   P51826-2   

Explore the universe of human proteins at neXtProt for AFF3: NX_P51826

Explore proteomics data for AFF3 at MOPED

Post-translational modifications: 

  • Modification sites at neXtProt
  • Modification sites at PhosphoSitePlus

  • See AFF3 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (2 alternative transcripts): 
    NP_001020279.1  NP_002276.2  

    ENSEMBL proteins: 
     ENSP00000387207   ENSP00000386834   ENSP00000416685   ENSP00000414099   ENSP00000406484  
     ENSP00000396582   ENSP00000399795   ENSP00000411383   ENSP00000395068   ENSP00000393732  
     ENSP00000407448   ENSP00000416131   ENSP00000317421   ENSP00000348793  

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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    1 InterPro protein domain:
     IPR007797 TF_AF4/FMR2

    Graphical View of Domain Structure for InterPro Entry P51826

    ProtoNet protein and cluster: P51826

    1 Blocks protein domain: IPB007797 AF-4 proto-oncoprotein

    UniProtKB/Swiss-Prot: AFF3_HUMAN, P51826
    Similarity: Belongs to the AF4 family


    Find genes that share domains with AFF3           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: AFF3_HUMAN, P51826
    Function: Putative transcription activator that may function in lymphoid development and oncogenesis. Binds, in
    vitro, to double-stranded DNA

         Gene Ontology (GO): 1 molecular function term:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003690double-stranded DNA binding IDA8555498
         
    Find genes that share ontologies with AFF3           About GenesLikeMe


    Phenotypes:
         1 GenomeRNAi human phenotype for AFF3:
     Increased gamma-H2AX phosphory 

         1 MGI mutant phenotype (inferred from 1 allele(MGI details for Aff3):
     skeleton 

    Find genes that share phenotypes with AFF3           About GenesLikeMe

    Animal Models:
       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for AFF3
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    Selected qRT-PCR Assays for microRNAs that regulate AFF3 (see all 138):
    hsa-miR-411* hsa-miR-576-3p hsa-miR-134 hsa-miR-1260b hsa-miR-4305 hsa-miR-128 hsa-miR-4275 hsa-miR-1273d
    SwitchGear 3'UTR luciferase reporter plasmidAFF3 3' UTR sequence
    Inhib. RNA
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    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    AFF3_HUMAN, P51826: Nucleus
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    nucleus5

    Gene Ontology (GO): 2 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus IDA8555498
    GO:0005730nucleolus ----

    Find genes that share ontologies with AFF3           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for AFF3
    Interactions:

        Search GeneGlobe Interaction Network for AFF3

    STRING Interaction Network Preview (showing 2 interactants - click image to see more details)

    5 Interacting proteins for AFF3 (P518263 ENSP000003487934) via UniProtKB, MINT, STRING, and/or I2D
    InteractantInteraction Details
    GeneCardExternal ID(s)
    MLLT3P425683, ENSP000003696954I2D: score=1 STRING: ENSP00000369695
    PTK2Q053973I2D: score=2 
    WNK1Q9H4A33I2D: score=2 
    IRS1P355683I2D: score=1 
    CDK9ENSP000003623614STRING: ENSP00000362361
    About this table

    Gene Ontology (GO): 4 biological process terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006351transcription, DNA-templated IEA--
    GO:0006355regulation of transcription, DNA-templated IEA--
    GO:0034612response to tumor necrosis factor IMP--
    GO:0035116embryonic hindlimb morphogenesis IMP18616733

    Find genes that share ontologies with AFF3           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for AFF3



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for AFF3 gene (2 alternative transcripts): 
    NM_001025108.1  NM_002285.2  

    Unigene Cluster for AFF3:

    AF4/FMR2 family, member 3
    Hs.444414  [show with all ESTs]
    Unigene Representative Sequence: NM_002285
    16 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000409236(uc010fiq.1) ENST00000409579(uc010fir.1 uc010yvr.1 uc002tah.1)
    ENST00000445815 ENST00000430789 ENST00000498090 ENST00000432037 ENST00000423966
    ENST00000441400 ENST00000424600 ENST00000416492 ENST00000440445 ENST00000415384
    ENST00000427118 ENST00000483600 ENST00000317233(uc002tag.3) ENST00000356421(uc002taf.3)

    miRNA
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    Selected qRT-PCR Assays for microRNAs that regulate AFF3 (see all 138):
    hsa-miR-411* hsa-miR-576-3p hsa-miR-134 hsa-miR-1260b hsa-miR-4305 hsa-miR-128 hsa-miR-4275 hsa-miR-1273d
    SwitchGear 3'UTR luciferase reporter plasmidAFF3 3' UTR sequence
    Inhib. RNA
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    Predesigned siRNA for gene silencing in human, mouse, rat AFF3
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    GenScript: all cDNA clones in your preferred vector (see all 2): AFF3 (NM_001025108)
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    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat AFF3
    Primer
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    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat AFF3
      QuantiTect SYBR Green Assays in human, mouse, rat AFF3
      QuantiFast Probe-based Assays in human, mouse, rat AFF3

    Additional mRNA sequence: 

    AB209634.1 AK055117.1 AK091320.1 AK092327.1 AK290468.1 AK297407.1 AK308645.1 AL832702.1 
    BC021283.2 BC036895.1 BC136579.1 BC144266.1 U34360.1 

    12 DOTS entries:

    DT.445740  DT.213449  DT.86837483  DT.120972230  DT.431851  DT.95262874  DT.120972389  DT.92417628 
    DT.99978926  DT.120972330  DT.120972443  DT.75174244 

    Selected AceView cDNA sequences (see all 62):

    AW172512 BI829437 AW134639 CB409656 CR596530 AW575892 BC036895 AI381467 
    AW183638 BE646040 AL704329 AK092327 AI810332 BM455726 BX338308 AL601353 
    AW971715 AW576594 AA251836 CD614446 AI990465 T07191 AI798984 AW502665 

    GeneLoc Exon Structure

    5 Alternative Splicing Database (ASD) splice patterns (SP) for AFF3    About this scheme

    ExUns: 1 ^ 2 ^ 3a · 3b ^ 4 ^ 5 ^ 6a · 6b ^ 7 ^ 8 ^ 9 ^ 10 ^ 11 ^ 12 ^ 13 ^ 14 ^ 15a · 15b ^ 16a · 16b ^ 17 ^ 18 ^ 19 ^ 20 ^ 21 ^ 22 ^
    SP1:                          -                                                                                                                                 
    SP2:                                                                                                                    -                                       
    SP3:                                                                                                                                                            
    SP4:                                                                                                                                                            
    SP5:                                                                                                                                                            

    ExUns: 23 ^ 24 ^ 25
    SP1:                  
    SP2:                  
    SP3:                  
    SP4:                  
    SP5:                  


    ECgene alternative splicing isoforms for AFF3

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    AFF3 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: TCTGCCTTTC
    AFF3 Expression
    About this image


    AFF3 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 18) fully expand
     
     Brain (Nervous System)    fully expand to see all 4 entries
             Endothelial Cells Blood Brain Barrier
             Cerebral Cortex
     
     Blood (Hematopoietic System)    fully expand to see all 3 entries
             Hematopoietic Stem Cells Hematopoietic Bone Marrow
             Umbilical cord blood-derived mesenchymal stem cells
     
     Neural Tube (Nervous System)    fully expand to see all 3 entries
             Metencephalon
     
     Umbilical Cord (Extraembryonic Tissues)    fully expand to see all 2 entries
             Umbilical cord-derived mesenchymal stem cells (family)
     
     Mesenchymal Stem Cells (Uncategorized)    fully expand to see all 2 entries
             Umbilical cord-derived mesenchymal stem cells (family)
    AFF3 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    AFF3 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.444414

    UniProtKB/Swiss-Prot: AFF3_HUMAN, P51826
    Tissue specificity: Preferentially expressed in lymphoid tissues, highest levels being found in the thymus

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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for AFF3

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of animals.

    Orthologs for AFF3 gene from Selected species (see all 13)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Aff31 , 5 AF4/FMR2 family, member 31, 5 85.63(n)1
    87.93(a)1
      1 (16.58 cM)5
    167641  NM_010678.21  NP_034808.21 
     381773265 
    chicken
    (Gallus gallus)
    Aves AFF31 AF4/FMR2 family, member 3 72.49(n)
    70.5(a)
      418705  XM_004938501.1  XP_004938558.1 
    lizard
    (Anolis carolinensis)
    Reptilia AFF36
    AF4/FMR2 family, member 3
    64(a)
    1 ↔ 1
    GL343456.1(158065-488154)
    tropical clawed frog
    (Xenopus tropicalis)
    Amphibia aff31 AF4/FMR2 family, member 3 60.51(n)
    54.5(a)
      100493499  XM_002937868.2  XP_002937914.2 
    zebrafish
    (Danio rerio)
    Actinopterygii aff36
    AF4/FMR2 family, member 3
    29(a)
    1 ↔ 1
    9(22524163-22540428) ENSDARG00000079575
    fruit fly
    (Drosophila melanogaster)
    Insecta lilli6
    lilliputian
    15(a)
    1 → many
    2L(2885929-2954406)


    ENSEMBL Gene Tree for AFF3 (if available)
    TreeFam Gene Tree for AFF3 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for AFF3 gene
    AFF12  AFF22  AFF42  
    3 SIMAP similar genes for AFF3 using alignment to 12 protein entries:     AFF3_HUMAN (see all proteins):
    AFF4    AFF1    AFF2

    Find genes that share paralogs with AFF3           About GenesLikeMe



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for AFF3 (see all 11001)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 2 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1180850521,2
    C,F--100163311(+) GGCATC/TCCAGG 2 -- ds50011Minor allele frequency- T:0.07EA 120
    rs75710751,2
    C,F,H--100163432(+) cgcgcG/Atgtgt 2 -- ds50018Minor allele frequency- A:0.00NS EA NA 1066
    rs739641611,2
    C,F--100163493(+) TATAAT/CGAAGA 2 -- ds50012Minor allele frequency- C:0.11WA 120
    rs1845943571,2
    --100163572(+) CCATTA/TATGAA 2 -- ds50010--------
    rs1996035721,2
    C--100163608(+) CTGGG-/GAGCCA 2 -- ds50010--------
    rs1892367241,2
    --100163633(+) TTGAAC/TGTATT 2 -- ds50010--------
    rs67501391,2
    C,F,H--100163655(+) GTTTCC/TGTGTA 2 -- ds50014Minor allele frequency- T:0.01NS EA 418
    rs1154277011,2
    C--100163743(+) TAACAC/TTTGCA 2 -- ut310--------
    rs341228481,2
    C--100163958(+) CTTGC-/TTTTTT 2 -- ut310--------
    rs1453414961,2
    C--100164093(+) ACTGAC/TTAATT 2 -- ut310--------

    HapMap Linkage Disequilibrium report for AFF3 (100162323 - 100412323 bp, first 250kb of AFF3)

    Structural Variations
         Database of Genomic Variants (DGV) Selected variations for AFF3 (see all 14):    About this table    
    Variant IDTypeSubtypePubMed ID
    esv2720434CNV Deletion23290073
    esv2720433CNV Deletion23290073
    esv2137645CNV Deletion18987734
    esv2662354CNV Deletion23128226
    esv272467CNV Insertion20981092
    nsv2846CNV Insertion18451855
    nsv2848CNV Insertion18451855
    esv270786CNV Insertion20981092
    nsv527481CNV Loss19592680
    nsv2845CNV Loss18451855

    Human Gene Mutation Database (HGMD): AFF3
    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing AFF3
    DNA2.0 Custom Variant and Variant Library Synthesis for AFF3

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 601464    OMIM disorders: --

    1 disease for AFF3:    
    About MalaCards
    fibular aplasia


    Find genes that share disorders with AFF3           About GenesLikeMe

    2 Novoseek inferred disease relationships for AFF3 gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    lymphoblastic leukemia acute 66.4 3 12743608 (1), 8555498 (1), 12203795 (1)
    leukemia 28.7 1 8555498 (1)

    Genetic Association Database (GAD): AFF3
    Human Genome Epidemiology (HuGE) Navigator: AFF3 (9 documents)

    Export disorders for AFF3 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for AFF3 gene, integrated from 10 sources (see all 38):
    (articles sorted by number of sources associating them with AFF3)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. LAF-4 encodes a lymphoid nuclear protein with transactivation potential that is homologous to AF-4, the gene fused to MLL in t(4;11) leukemias. (PubMed id 8555498)1, 2, 3, 9 Ma C. and Staudt L.M. (Blood 1996)
    2. Investigation of rheumatoid arthritis susceptibility genes identifies association of AFF3 and CD226 variants with response to anti-tumour necrosis factor treatment. (PubMed id 20444755)1, 4 Tan R.J....Barton A. (Ann. Rheum. Dis. 2010)
    3. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PubMed id 20379614)1, 4 Rose J.E....Uhl G.R. (Mol. Med. 2010)
    4. Genome-wide association study meta-analysis identifies seven new rheumatoid arthritis risk loci. (PubMed id 20453842)1, 4 Stahl E.A....Plenge R.M. (Nat. Genet. 2010)
    5. Association of the AFF3 gene and IL2/IL21 gene region with juvenile idiopathic arthritis. (PubMed id 20072139)1, 4 Hinks A....Thomson W. (Genes Immun. 2010)
    6. Investigation of potential non-HLA rheumatoid arthritis susceptibility loci in a European cohort increases the evidence for nine markers. (PubMed id 20498205)1, 4 Plant D....Worthington J. (Ann. Rheum. Dis. 2010)
    7. Coeliac disease-associated risk variants in TNFAIP3 and REL implicate altered NF-kappaB signalling. (PubMed id 19240061)1, 4 Trynka G....Wijmenga C. (Gut 2009)
    8. Robust associations of four new chromosome regions from genome-wide analyses of type 1 diabetes. (PubMed id 17554260)1, 4 Todd J.A.... Clayton D.G. (Nat. Genet. 2007)
    9. Generation and annotation of the DNA sequences of human chromosomes 2 and 4. (PubMed id 15815621)1, 2 Hillier L.W.... Wilson R.K. (Nature 2005)
    10. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section

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    Entrez Gene: 3899 HGNC: 6473 AceView: LAF4 Ensembl:ENSG00000144218 euGenes: HUgn3899
    ECgene: AFF3 H-InvDB: AFF3

    (According to HUGE)
    About This Section

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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
    About This Section

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    NameDescription
    PharmGKB entry for AFF3 Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for AFF3 Genetics and Cytogenetics in Oncology and Haematology

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section

    TryGeneCards Plus
    Patent Information for AFF3 gene:
    Search GeneIP for patents involving AFF3

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, eBioscience, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
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