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AFF3 Gene

protein-coding GIFtS: 54

GC02M099627

AF4/FMR2 family, member 3
(Previous name: lymphoid nuclear protein related to AF4 )
Symbol approved by the HUGO Gene Nomenclature Committee (HGNC) database
(Previous symbol: LAF4)

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc , and/or ⁷Ensembl, ⁸miRBase)
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Aliases
LAF4 ^², ³
MLLT2-like ^¹, ²

Descriptions
AF4/FMR2 family, member 3 ^²
Lymphoid nuclear protein related to AF4 ^¹, ², ³
MLLT2-related protein ^²
Protein LAF-4 ^³
lymphoid nuclear protein 4 ^²

External Ids
HGNC: 6473¹
Entrez Gene: 3899²
UniProtKB: P51826³
Ensembl: ENSG00000144218⁷

Search outside databases for aliases for AFF3 gene

(According to Entrez Gene, Wikipedia's Gene Wiki,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

EntrezGene summary for AFF3:

This gene encodes a tissue-restricted nuclear transcriptional activator that is preferentially

expressed in lymphoid tissue. Isolation of this protein initially defined a highly conserved

LAF4/MLLT2 gene family of nuclear transcription factors that may function in lymphoid development

and oncogenesis. In some ALL patients, this gene has been found fused to the gene for MLL.

Multiple alternatively spliced transcript variants that encode different proteins have been found

for this gene. [provided by RefSeq]

UniProtKB/Swiss-Prot: AFF3_HUMAN, P51826

Function: Putative transcription activator that may function in lymphoid development and

oncogenesis. Binds, in vitro, to double-stranded DNA

Gene Wiki entry for AFF3

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 36),
and/or miRBase,
Genomic Views according to UCSC and Ensembl, Transcription factor binding sites according to SABiosciences)
About This Section

Genomic View:

UCSC Golden Path with GeneCards custom track

Transcription factor binding sites upstream to the AFF3 gene

Entrez Gene cytogenetic band: 2q11.2-q12 Ensembl cytogenetic band: 2q11.2 HGNC cytogenetic band: 2q11.2-q12

AFF3 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)

GeneLoc gene densities for chromosome 2 GeneLoc Exon Structure

GeneLoc location for GC02M099627: (about GC identifiers)

Start:	99,530,147 bp from pter
End:	100,125,469 bp from pter
Size:	595,323 bases
Orientation:	minus strand

RefSeq DNA sequence:

NC_000002.10 NT_022171.14

(According to ¹UniProtKB, and/or Ensembl, Phosphorylation sites according to ²Phosphosite, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Enzo Life Sciences, Abnova, OriGene and/or, Abcam,
Biochemical Assays by Invitrogen, Millipore, R&D Systems, Cell Signaling Technology, and/or Enzo Life Sciences, Ontologies according to Gene Ontology Consortium 01 Apr 2009 and Entrez Gene, Antibodies by Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Cell Signaling Technology, Abcam, Abnova, and/or Novus Biologicals)
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UniProtKB/Swiss-Prot: AFF3_HUMAN, P51826 (See protein sequence)

Recommended Name: AF4/FMR2 family member 3

Size: 1226 amino acids; 133476 Da

Subcellular location: Nucleus

Secondary accessions: Q53RD6 Q53S47 Q53SI6 Q53TB9 Q59F27 Q8IWJ5

Post-translational modifications:

View phosphorylation sites using PhosphoSite²

REFSEQ proteins (2 alternative transcripts):

NP_001020279.1 NP_002276.2

ENSEMBL proteins:

ENSP00000387207 ENSP00000386834 ENSP00000317421 ENSP00000348793

Human Recombinant Proteins

	Browse Drug Discovery Central at Invitrogen for human recombinant proteins
	Browse Purified and Recombinant Proteins at Millipore
	Browse Human Recombinant Proteins at Sigma-Aldrich
	Browse R&D Systems for human recombinant proteins
	Browse recombinant and purified proteins available from Enzo Life Sciences
	Recombinant Proteins from Abcam (LAF4)
	Browse Abnova for Human Recombinant Proteins

Browse Origene for full length recombinant human proteins expressed in human HEK293 cells

1 Gene Ontology (GO) cellular component term (links to tree view):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005634	nucleus	TAS	8555498

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Antibodies for AFF3:

	Browse Antibodies Central at Invitrogen
	Browse Millipore's Extensive Line of Mono- and Polyclonal Antibodies
	Browse Antibodies at Sigma-Aldrich
	Browse R&D Systems for Antibodies
	Antibodies from Abcam (LAF4), each with their Abpromise^SM
	Monoclonal and Polyclonal Antibodies from Abnova (AFF3)
	Search Novus for antibodies for AFF3

Assays for AFF3:

	Browse Invitrogen for biochemical assays
	Browse Kits and Assays available from Millipore
	Browse R&D Systems for biochemical assays
	Browse biochemical assays available from Enzo Life Sciences

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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Graphical View of Domain Structure for InterPro Entry P51826

ProtoNet protein and cluster: P51826

1 Blocks protein family: IPB007797 AF-4 proto-oncoprotein

UniProtKB/Swiss-Prot: AFF3_HUMAN, P51826

Similarity: Belongs to the AF4 family

(According to MGI Jun 06 2009, UniProtKB, IUBMB,and/or Genatlas,
shRNA from OriGene, Sigma-Aldrich, RNAi from Sigma-Aldrich,
RNAi Products, Clones, and Q-PCR Products from Invitrogen, Millipore, OriGene, and/or Abnova, siRNAs from Applied Biosystems, SYBR primers from OriGene, Cell-based Assays from Millipore, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
About This Section

Inhib. RNA:		Invitrogen RNAi Products for gene knock-down (AFF3)
		Browse for Gene Knock-down Tools from Millipore
		Abnova Chimera RNAi Products for Gene knock-down (AFF3)

OriGene 29mer shRNA kit in GFP-retroviral vectors (see all 2): NM_002285

Applied Biosystems Silencer® siRNAs for AFF3

Sigma-Aldrich siRNA for AFF3

Sigma-Aldrich shRNA for AFF3

Explore Sigma-Aldrich super-pooled esiRNAs

Clones:		Browse Clone Ranger at Invitrogen for clones
		Browse Clones for the Expression of Recombinant Proteins Available from Millipore

OriGene GFP tagged cDNA clones in CMV expression vector (see all 2): NM_001025108
Myc/DDK tagged cDNA clones in CMV expression vector (see all 2): NM_001025108
untagged cDNA clones in CMV expression vector (see all 3): NM_001025108

Primers:

Browse Quantitative PCR Central at Invitrogen for Q-PCR LUX™ Primers

OriGene genome-wide validated SYBR primer pairs: NM_001025108

UniProtKB/Swiss-Prot: AFF3_HUMAN, P51826

Function: Putative transcription activator that may function in lymphoid development and

oncogenesis. Binds, in vitro, to double-stranded DNA

1 Gene Ontology (GO) molecular function term (links to tree view):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0003677	DNA binding	IEA	--

About this table

(Pathways according to Invitrogen (maps by GeneGo), Millipore, Cell Signaling Technology, Sigma-Aldrich, KEGG and/or UniProtKB,
Sets of similar genes according to GeneDecks, Proteins Network according to SABiosciences, Interactions according to ¹UniProtKB, ²MINT, and/or ³STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
About This Section

2 Interacting proteins for AFF3 (ENSP00000348793³) via UniProtKB, MINT, and/or STRING

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
ELL2	ENSP00000237853³	STRING (score=.811)
ELL	ENSP00000262809³	STRING (score=.787)

About this table

3 Gene Ontology (GO) biological process terms (links to tree view):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0006350	transcription	IEA	--
GO:0006355	regulation of transcription, DNA-dependent	IEA	--
GO:0007275	multicellular organismal development	TAS	8555498

About this table

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, Sigma-Aldrich, Tocris Bioscience, and/or Novoseek and Drugs according to Enzo Life Sciences and/or PharmGKB)
About This Section

Browse drugs & compounds from Enzo Life Sciences

Browse Small Molecules at Sigma-Aldrich

Browse Tocris compounds for AFF3

(GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 219 Homo sapiens; Jun 2 2009) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView,
non coding RNAs according to RNAdb,
ESTs according to GeneTide,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from Invitrogen, Millipore, and/or Abnova,
siRNAs from Applied Biosystems, Sigma-Aldrich,
shRNA from Sigma-Aldrich, OriGene,
Tagged/untagged cDNA clones from OriGene,
Expression Assays from Applied Biosystems)
About This Section

Inhib. RNA:		Invitrogen RNAi Products for gene knock-down (AFF3)
		Browse for Gene Knock-down Tools from Millipore
		Abnova Chimera RNAi Products for Gene knock-down (AFF3)

OriGene 29mer shRNA kit in GFP-retroviral vectors (see all 2): NM_002285

Sigma-Aldrich siRNA for AFF3

Sigma-Aldrich shRNA for AFF3

Explore Sigma-Aldrich super-pooled esiRNAs

Applied Biosystems Silencer® siRNAs:

NM_001025108 NM_002285

REFSEQ mRNAs for AFF3 gene (2 alternative transcripts):

NM_001025108.1 NM_002285.2

Applied Biosystems TaqMan ® Gene Expression Assays:

NM_001025108 NM_002285

               OriGene GFP tagged cDNA clones in CMV expression vector (see all 2): NM_001025108
                                 Myc/DDK tagged cDNA clones in CMV expression vector (see all 2): NM_001025108
                                 untagged cDNA clones in CMV expression vector (see all 3): NM_001025108

Additional cDNA sequence:

AB209634.1 AK055117.1 AK091320.1 AK092327.1 AK290468.1 AK297407.1 AK308645.1 AL832702.1

BC021283.2 BC036895.1 BC136579.1 BC144266.1 CR596530.1 U34360.1 XM_001715031.1

11 DOTS entries:

DT.445740 DT.213449 DT.86837483 DT.120972230 DT.431851 DT.95262874 DT.120972389 DT.92417628

DT.120972330 DT.120972443 DT.75174244

24/62 AceView cDNA sequences (see all 62 ):

AI381467 BC036895 CR596530 AW575892 AW183638 CB409656 BI829437 AW134639

AL704329 BE646040 AW172512 AW449091 U34360 AI990465 AA251836 AW167756

BM455726 BU929881 AI084050 AK092327 AU118377 BX338308 AI798984 BX112145

highest scoring ESTs for AFF3:

AK092327 BC036895 BI906088 U34360 AA251836 AA258840 AA259002 AA688175 AA744685 AA767530

Unigene Cluster for AFF3:

AF4/FMR2 family, member 3

Hs.444414 [show with all ESTs]

Unigene Representative Sequence: NM_002285

GeneLoc Exon Structure

5 Alternative Splicing Database (ASD) splice patterns (SP) for AFF3

ExUns:	1	^	2	^	3a	·	3b	^	4	^	5	^	6a	·	6b	^	7	^	8	^	9	^	10	^	11	^	12	^	13	^	14	^	15a	·	15b	^	16a	·	16b	^	17	^	18	^	19	^	20	^	21	^	22	^
SP1:									-
SP2:																																							-
SP3:
SP4:
SP5:

ExUns:	23	^	24	^	25
SP1:
SP2:
SP3:
SP4:
SP5:

About this scheme

ECgene alternative splicing isoforms for AFF3

4 Ensembl transcripts including schematic representations:

ENST00000409236 ENST00000409579 ENST00000317233 ENST00000356421

(Experimental results according to ¹GeneNote and GNF BioGPS,
probe sets-to-genes annotations according to ²GeneAnnot , ³GeneTide , Sets of similar genes according to GeneDecks, Electronic Northern calculations according to data from UniGene (Build 219 Homo sapiens), SAGE tags according to CGAP, plus additional links to SOURCE, and/or GNF BioGPS, and/or EXPOLDB, and/or UniProtKB,
Expression Assays from Applied Biosystems )
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AFF3 expression in normal and diseased human tissues

Applied Biosystems TaqMan ® Gene Expression Assays for AFF3

¹ / ² / ³

12 probe-sets matching AFF3 gene

Affymetrix probe-set	Array	# genes	Sensitivity	Specificity	Correlation	Length	Gb_Accession	Consensus	Uniqueness	Score	Rank
Affymetrix probe-set	Array	GeneAnnot data			GeneNote data		GeneTide data
87109_at²^{, 3}	U95-D	1	1.00	1.00	0.93	1.22	AI424899	0.60	1.00	0.82	1
41543_at²^{, 3}	U95-A	1	1.00	1.00	-0.07	0.70	U34360	0.80	1.00	0.91	1
53751_at²^{, 3}	U95-B	1	1.00	1.00	0.89	1.12	W57554	0.60	1.00	0.82	1
205734_s_at²^{, 3}	U133-A	1	1.00	1.00	--	--	AI990465	0.60	1.00	0.82	1
243967_at²^{, 3}	U133-B	1	1.00	1.00	--	--	AI424899	0.60	1.00	0.82	1
227198_at²^{, 3}	U133-B	1	1.00	1.00	--	--	AW085505	0.40	1.00	0.76	1
205735_s_at²^{, 3}	U133-A	1	1.00	1.00	--	--	NM_002285	0.60	1.00	0.82	1
205734_s_at²	U133Plus2	1	1.00	1.00	--	--	--	--	--	--	--
243967_at²	U133Plus2	1	1.00	1.00	--	--	--	--	--	--	--
227198_at²	U133Plus2	1	1.00	1.00	--	--	--	--	--	--	--
205735_s_at²	U133Plus2	1	1.00	1.00	--	--	--	--	--	--	--
1565034_s_at²	U133Plus2	2	1.00	0.50	--	--	--	--	--	--	--

GeneDecks AFF3 for binary patterns associated with the probe-sets selected above

About GeneDecksing

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Data from

(Publications) and GNF BioGPS
About these images
About these images

CGAP SAGE TAG: --

SOURCE GeneReport for Unigene cluster: Hs.444414
Expression variation in blood from EXPOLDB for AFF3
UniProtKB/Swiss-Prot: AFF3_HUMAN, P51826
Tissue specificity: Preferentially expressed in lymphoid tissues, highest levels being found in the
thymus

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD and/or ⁵MGI Jun 06 2009, with possible further links to Flybase and/or WormBase, Gene Trees according to Ensembl)
About This Section

Orthologs for AFF3 gene from 5/6 species (see all 6 )

Organism	Gene	Locus	Description	Human Similarity	NCBI accessions
dog (Canis familiaris)	AFF3¹	--	AF4/FMR2 family, member 3	91.1(n) 92.92(a)	611584 XM_849267.1 XP_854360.1
chimpanzee (Pan troglodytes)	AFF3¹	--	AF4/FMR2 family, member 3	99.39(n) 99.36(a)	470450 XM_001160570.1 XP_001160570.1
rat (Rattus norvegicus)	Aff3¹	--	AF4/FMR2 family, member 3	86.56(n) 88.79(a)	363220 XM_343559.3 XP_343560.3
mouse (Mus musculus)	Aff3^{1, 5}	1 (18.70 cM)⁵	AF4/FMR2 family, member 3^{1, 5}	86.38(n)¹ 88.76(a)¹	16764¹ XM_001477293.1¹ XP_001477343.1¹ AC122026⁵ AK014322⁵ (see all 10)
chicken (Gallus gallus)	AFF3¹	--	AF4/FMR2 family, member 3	73.67(n) 71.88(a)	418705 XM_001233771.1 XP_001233772.1

About this table Species with no ortholog for AFF3

ENSEMBL Gene Tree for AFF3

(Paralogs according to ¹HomoloGene
and ²Ensembl, Pseudogenes according to ³Pseudogene.org)
About This Section

Paralogs for AFF3 gene

AFF1² AFF2² AFF4²

(According to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, and UniProtKB, Linkage Disequilibrium by HapMap, Genotyping Reagents from Applied Biosystems)
About This Section

10/2575 NCBI SNPs in AFF3 are shown (see all 2575 )
(Click for Applied Biosystems TaqMan ® Genotyping Assay) (see all 852)

AB	SNP ID	Valid	Chr 2 pos	Sequence	Recs	AA Chg	Type	More	Recs	Allele freq	Pop	Total sample	More
AB	Genomic Data				Transcription Data				Allele Frequencies
				--	--	--		--	--				--
	rs11123807^1,2	A,C,F,H	100090077(+)	`AAATAA/GTAGTT`	2	--	ng3¹ int¹		4		EU EA WA	418
	rs4851212^1,2	A,C,F,H	99533671(+)	`GCTGTG/AAGTGT`	2	--	ut3¹ ese³		8		EU EA WA	836
	rs13427251^1,2	A,C,F,H	99532886(+)	`AGGCCA/TCAAGG`	2	--	ut3¹ ese³		4		EU EA WA	412
	rs1047265^1,2	C,F,H	99577074(-)	`GAGCAA/GTCAGT`	2	N/S	mis¹		11		MN EU EA WA NA	1191
	rs4851223^1,2	A,C,H	99709989(+)	`TGCCAT/CTGTCT`	2	S/N	mis¹ ese³		4		EU EA WA	418
	rs13429281^1,2	F,H	100089395(+)	`AATGTT/ATGCTT`	2	--	ng3¹ int¹ tfbs³		4		EU EA WA	418
	rs6750139^1,2	F,H	99530087(+)	`GTTTCC/TGTGTA`	2	--	ng5¹		4		EU EA WA	418
	rs1866033^1,2	A	100089340(-)	`CTTTTC/TCTTTT`	2	--	ng3¹ int¹ tfbs³ trp³		0	--	--	--	--
	rs11123806^1,2	H	100089103(+)	`TGCAAA/CATGTA`	2	--	int¹ ng3¹		4		EU EA WA	418
	rs7571075^1,2	H	99529864(+)	`cgcgcG/Atgtgt`	2	--	ng5¹		4		EU EA WA	416

About this table

HapMap Linkage Disequilibrium images for AFF3 (up to first 250kb)

(in which this Gene is Involved, According to OMIM, UniProtKB, Novoseek, PharmGKB, Genatlas, GeneTests, Blood group antigen gene mutations by BGMUT, HGMD, GAD, HuGE Navigator, BCGD, and/or TGDB.)
About This Section

OMIM: 601464

2 Novoseek disease relationships for AFF3 gene

Disease	Score	Articles	PubMed IDs for Articles with Shared Sentences (# sentences)
lymphoblastic leukemia acute	67.13	3	12743608 (1), 8555498 (1), 12203795 (1)
leukemia	29.55	1	8555498 (1)

About this table

Human Gene Mutation Database: AFF3
Human Genome Epidemiology Navigator: AFF3 (1 document)

(Possibly Related Articles in Doctor's Guide)
About This Section

(in PubMed. Associations of this gene to articles via ¹Novoseek, ²HGNC, ³Entrez Gene, ⁴UniProtKB/Swiss-Prot, ⁵UniProtKB/TrEMBL, ⁶GAD, and/or ⁷PharmGKB)
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10/18 PubMed articles for AFF3 gene (see all 18 ):

LAF-4 encodes a lymphoid nuclear protein with transactivation potential that is homologous to AF-4, the gene fused to MLL in t(4;11) leukemias. (PubMed id 8555498)^{1, 2, 3, 4} Ma C. and Staudt L.M. (1996)
Generation and annotation of the DNA sequences of human chromosomes 2 and 4. (PubMed id 15815621)^{3, 4} Hillier L.W....Wilson R.K. (2005)
The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)^{3, 4} Gerhard D.S....Malek J. (2004)
LAF4 maps to mouse chromosome 1 and human chromosome 2q11.2-q12. (PubMed id 8662235)^{2, 3} Liao X....Copeland N.G. (1996)
Fusion of an AF4-related gene, LAF4, to MLL in childhood acute lymphoblastic leukemia with t(2;11)(q11;q23). (PubMed id 12743608)^{1, 3} Hiwatari M....Hayashi Y. (2003)
LAF4, an AF4-related gene, is fused to MLL in infant acute lymphoblastic leukemia. (PubMed id 12203795)^{1, 3} von Bergh A.R....Schuuring E. (2002)
Coeliac disease associated risk variants in TNFAIP3 and REL implicate altered NF-{kappa}B signalling. (PubMed id 19240061)³ Trynka G....Wijmenga C. (2009)
Triangular tibia with fibular aplasia associated with a microdeletion on 2q11.2 encompassing LAF4. (PubMed id 18616733)³ Steichen-Gersdorf E....Mundlos S. (2008)
A quantitative atlas of mitotic phosphorylation. (PubMed id 18669648)⁴ Dephoure N.... Gygi S.P. (2008)
A novel fusion 5'AFF3/3'BCL2 originated from a t(2;18)(q11.2;q21.33) translocation in follicular lymphoma. (PubMed id 18622426)³ Impera L....Storlazzi C.T. (2008)

(in PubMed, OMIM, and NCBI Bookshelf)
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		AND	OR
Aliases
Free Text

Query String		PubMed OMIM NCBI Bookshelf
	(Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, and/or H-InvDB)
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Entrez Gene: 3899	HGNC: 6473	AceView: LAF4	Ensembl:ENSG00000144218	euGenes: HUgn3899
ECgene: AFF3	H-InvDB: AFF3

(According to HUGE)
About This Section

(According to ATLAS, HORDE, IMGT, MTDB, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
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Name	Description
ATLAS Chromosomes in Cancer entry for AFF3	Genetics and Cytogenetics in Oncology and Haematology

Licensable Technologies for AFF3
(Available from WIS Yeda, Salk, Tufts)

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(Reagents available from Applied Biosystems, Antibodies and assays by Cell Signaling Technology, Abcam, Novus Biologicals,
Sigma-Aldrich, R&D Systems, Millipore, Abnova, and/or Invitrogen, Clones available from OriGene,and/or Invitrogen, Drugs and/or compounds by Sigma-Aldrich,
Enzo Life Sciences, and/or Tocris Bioscience)
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Products for AFF3:

TaqMan ® Gene Expression Assays

TaqMan ® Genotyping Assays

Free SNP selection tool

Invitrogen iPath Pathways	Invitrogen BLOCK-iT™ RNAi
Invitrogen Antibodies	Invitrogen Assays
Invitrogen Clones	Invitrogen Q-PCR Products
Invitrogen Human Recombinant Kinases	Invitrogen Custom Antibody and Peptide Service
Invitrogen Proteins / Assays / Screening Services	Search Invitrogen catalog for AFF3-related products

	Millipore Custom Antibody & Bulk Services
	Millipore Preclinical / Clinical Development Services
	Millipore Immunoassay Services
	Millipore Target Screening & Profiling Services

	Predesigned and custom siRNAs for AFF3		Browse antibodies at Sigma-Aldrich
	Explore super-pooled esiRNAs		Browse proteins at Sigma-Aldrich
	Lentivirus-delivered shRNAs for AFF3		Browse small molecules at Sigma-Aldrich
	"Your Favorite Gene" Pathways		feedback

	Antibodies		Primer Pairs
	Cell Culture Products		ELISAs
	Flow Cytometry Kits		Protease Activity Assays & Reagents
	Cell Selection/Detection Kits & Reagents		ELISA/Assay Development Kits & Reagents
	Multiplex/Array Assay Kits & Reagents		ELISpot Kits & Development Modules
	Recombinant & Natural Proteins

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Search Tocris compounds for AFF3

Search www.enzolifesicences.com for proteins, assays, substrates, inhibitors & antibodies

Search Novus for antibodies for AFF3

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AFF3 Gene

protein-coding GIFtS: 54

Aliases &
Descriptions
for AFF3

Summaries
for AFF3

Genomic Location
for AFF3

Proteins
for AFF3

Protein Domains/
Families
for AFF3

Gene Function
for AFF3

Pathways & Interactions
for AFF3

Drugs & Compounds
for AFF3

Transcripts
for AFF3

Expression
for AFF3

Orthologs
for AFF3

Paralogs
for AFF3

SNPs/Variants
for AFF3

Disorders & Mutations
for AFF3

Medical News
for AFF3

Publications
for AFF3

Search for AFF3

Genome Databases showing AFF3

Other Databases showing AFF3

Specialized Databases showing AFF3

Licensable Technologies
for AFF3

Services
for AFF3

Gene Index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

AFF3 Gene

protein-coding GIFtS: 54

Aliases & Descriptionsfor AFF3

Summariesfor AFF3

Genomic Locationfor AFF3

Proteinsfor AFF3

Protein Domains/Familiesfor AFF3

Gene Functionfor AFF3

Pathways & Interactionsfor AFF3

Drugs & Compoundsfor AFF3

Transcriptsfor AFF3

Expression for AFF3

Orthologsfor AFF3

Paralogsfor AFF3

SNPs/Variantsfor AFF3

Disorders & Mutationsfor AFF3

Medical Newsfor AFF3

Publicationsfor AFF3

Search for AFF3

Genome Databases showing AFF3

Other Databases showing AFF3

Specialized Databases showing AFF3

Licensable Technologiesfor AFF3

Servicesfor AFF3

Gene Index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

Aliases &
Descriptions
for AFF3

Summaries
for AFF3

Genomic Location
for AFF3

Proteins
for AFF3

Protein Domains/
Families
for AFF3

Gene Function
for AFF3

Pathways & Interactions
for AFF3

Drugs & Compounds
for AFF3

Transcripts
for AFF3

Expression
for AFF3

Orthologs
for AFF3

Paralogs
for AFF3

SNPs/Variants
for AFF3

Disorders & Mutations
for AFF3

Medical News
for AFF3

Publications
for AFF3

Licensable Technologies
for AFF3

Services
for AFF3