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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

AFF3 Gene

protein-coding   GIFtS: 55
GCID: GC02M100163

AF4/FMR2 Family, Member 3

(Previous name: lymphoid nuclear protein related to AF4)
(Previous symbol: LAF4)
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
AF4/FMR2 Family, Member 31 2     MLLT2-like2
LAF41 2 3 5     AF4/FMR2 Family Member 32
Lymphoid Nuclear Protein Related To AF41 2 3     Lymphoid Nuclear Protein 42
Protein LAF-42 3     MLLT2-Related Protein2

External Ids:    HGNC: 64731   Entrez Gene: 38992   Ensembl: ENSG000001442187   OMIM: 6014645   UniProtKB: P518263   

Export aliases for AFF3 gene to outside databases

Previous GC identifers: GC02M099627 GC02M093928


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for AFF3 Gene:
This gene encodes a tissue-restricted nuclear transcriptional activator that is preferentially expressed in
lymphoid tissue. Isolation of this protein initially defined a highly conserved LAF4/MLLT2 gene family of nuclear
transcription factors that may function in lymphoid development and oncogenesis. In some ALL patients, this gene
has been found fused to the gene for MLL. Multiple alternatively spliced transcript variants that encode
different proteins have been found for this gene. (provided by RefSeq, Jul 2008)

GeneCards Summary for AFF3 Gene: 
AFF3 (AF4/FMR2 family, member 3) is a protein-coding gene. Diseases associated with AFF3 include fibular aplasia, and follicular lymphoma. GO annotations related to this gene include double-stranded DNA binding. An important paralog of this gene is AFF1.

UniProtKB/Swiss-Prot: AFF3_HUMAN, P51826
Function: Putative transcription activator that may function in lymphoid development and oncogenesis. Binds, in
vitro, to double-stranded DNA

Gene Wiki entry for AFF3 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000002.11  NT_022171.15  NC_018913.2  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the AFF3 gene promoter:
         AML1a   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmids (see all 2): AFF3 promoter sequence
   Search SABiosciences Chromatin IP Primers for AFF3

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat AFF3


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 2q11.2-q12   Ensembl cytogenetic band:  2q11.2   HGNC cytogenetic band: 2q11.2-q12

AFF3 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
AFF3 gene location

GeneLoc information about chromosome 2         GeneLoc Exon Structure

GeneLoc location for GC02M100163:  view genomic region     (about GC identifiers)

Start:
100,163,715 bp from pter      End:
100,759,201 bp from pter
Size:
595,487 bases      Orientation:
minus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: AFF3_HUMAN, P51826 (See protein sequence)
Recommended Name: AF4/FMR2 family member 3  
Size: 1226 amino acids; 133476 Da
Subcellular location: Nucleus
Secondary accessions: B7ZM46 B9EGL9 D3DVI6 Q53RD6 Q53S47 Q53SI6 Q53TB9 Q59F27 Q8IWJ5
Alternative splicing: 2 isoforms:  P51826-1   P51826-2   

Explore the universe of human proteins at neXtProt for AFF3: NX_P51826

Explore proteomics data for AFF3 at MOPED 

Post-translational modifications:

  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_P51826

  • AFF3 Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    AFF3 Protein Expression
    REFSEQ proteins (2 alternative transcripts): 
    NP_001020279.1  NP_002276.2  

    ENSEMBL proteins: 
     ENSP00000386834   ENSP00000387207   ENSP00000416685   ENSP00000414099   ENSP00000406484  
     ENSP00000396582   ENSP00000399795   ENSP00000411383   ENSP00000395068   ENSP00000393732  
     ENSP00000407448   ENSP00000416131   ENSP00000317421   ENSP00000348793  

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    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for AFF3 

    Gene Ontology (GO): 2 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus IDA--
    GO:0005730nucleolus IDA--

    AFF3 for ontologies           About GeneDecksing



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    Cloud-Clone Corp. CLIAs for AFF3


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    1 InterPro protein domain:
     IPR007797 TF_AF4/FMR2

    Graphical View of Domain Structure for InterPro Entry P51826

    ProtoNet protein and cluster: P51826

    1 Blocks protein domain: IPB007797 AF-4 proto-oncoprotein

    UniProtKB/Swiss-Prot: AFF3_HUMAN, P51826
    Similarity: Belongs to the AF4 family


    AFF3 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: AFF3_HUMAN, P51826
    Function: Putative transcription activator that may function in lymphoid development and oncogenesis. Binds, in
    vitro, to double-stranded DNA

         Gene Ontology (GO): 1 molecular function term (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003690double-stranded DNA binding IDA8555498
         
    AFF3 for ontologies           About GeneDecksing


    Phenotypes:
         1 GenomeRNAi human phenotype for AFF3:
     Increased gamma-H2AX phosphory 

         1 MGI mutant phenotype (inferred from 1 allele(MGI details for Aff3):
     skeleton 

    AFF3 for phenotypes           About GeneDecksing

    Animal Models:
       inGenious Targeting Laboratory - Custom generated mouse model solutions for AFF3 
       inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for AFF3

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for AFF3 
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    hsa-miR-411* hsa-miR-576-3p hsa-miR-134 hsa-miR-1260b hsa-miR-4305 hsa-miR-128 hsa-miR-4275 hsa-miR-1273d
    SwitchGear 3'UTR luciferase reporter plasmidAFF3 3' UTR sequence
    Inhib. RNA
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for AFF3


    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section



    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for AFF3

    STRING Interaction Network Preview (showing 1 interactants - click image to see more details)

    4 Interacting proteins for AFF3 (P518263 ENSP000003487934) via UniProtKB, MINT, STRING, and/or I2D
    InteractantInteraction Details
    GeneCardExternal ID(s)
    MLLT3P425683, ENSP000003696954I2D: score=1 STRING: ENSP00000369695
    PTK2Q053973I2D: score=2 
    WNK1Q9H4A33I2D: score=2 
    IRS1P355683I2D: score=1 
    About this table

    Gene Ontology (GO): 4 biological process terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006351transcription, DNA-dependent IEA--
    GO:0006355regulation of transcription, DNA-dependent IEA--
    GO:0034612response to tumor necrosis factor IMP--
    GO:0035116embryonic hindlimb morphogenesis IMP18616733

    AFF3 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for AFF3

    Search CenterWatch for drugs/clinical trials and news about AFF3

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for AFF3 gene (2 alternative transcripts): 
    NM_001025108.1  NM_002285.2  

    Unigene Cluster for AFF3:

    AF4/FMR2 family, member 3
    Hs.444414  [show with all ESTs]
    Unigene Representative Sequence: NM_002285
    16 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000409579(uc010fir.1 uc010yvr.1 uc002tah.1) ENST00000409236(uc010fiq.1)
    ENST00000445815 ENST00000430789 ENST00000498090 ENST00000432037 ENST00000423966
    ENST00000441400 ENST00000424600 ENST00000416492 ENST00000440445 ENST00000415384
    ENST00000427118 ENST00000483600 ENST00000317233(uc002tag.3) ENST00000356421(uc002taf.3)

    miRNA
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    8/138 QIAGEN miScript miRNA Assays for microRNAs that regulate AFF3 (see all 138):
    hsa-miR-411* hsa-miR-576-3p hsa-miR-134 hsa-miR-1260b hsa-miR-4305 hsa-miR-128 hsa-miR-4275 hsa-miR-1273d
    SwitchGear 3'UTR luciferase reporter plasmidAFF3 3' UTR sequence
    Inhib. RNA
    Products:
         
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    DNA2.0 Custom Codon Optimized Gene Synthesis Service for AFF3
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat AFF3
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      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat AFF3
      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat AFF3

    Additional mRNA sequence: 

    AB209634.1 AK055117.1 AK091320.1 AK092327.1 AK290468.1 AK297407.1 AK308645.1 AL832702.1 
    BC021283.2 BC036895.1 BC136579.1 BC144266.1 U34360.1 

    12 DOTS entries:

    DT.445740  DT.213449  DT.86837483  DT.120972230  DT.431851  DT.95262874  DT.120972389  DT.92417628 
    DT.99978926  DT.120972330  DT.120972443  DT.75174244 

    24/62 AceView cDNA sequences (see all 62):

    AW575892 CR596530 BC036895 AL704329 AW134639 BE646040 AI381467 AW172512 
    AW183638 BI829437 CB409656 BF941029 AW500422 AI990465 AI798984 AI375896 
    CD614446 T07191 BM455726 AW505312 NM_002285 AX747484 BX112145 AW167756 

    GeneLoc Exon Structure

    5 Alternative Splicing Database (ASD) splice patterns (SP) for AFF3    About this scheme

    ExUns: 1 ^ 2 ^ 3a · 3b ^ 4 ^ 5 ^ 6a · 6b ^ 7 ^ 8 ^ 9 ^ 10 ^ 11 ^ 12 ^ 13 ^ 14 ^ 15a · 15b ^ 16a · 16b ^ 17 ^ 18 ^ 19 ^ 20 ^ 21 ^ 22 ^
    SP1:                          -                                                                                                                                 
    SP2:                                                                                                                    -                                       
    SP3:                                                                                                                                                            
    SP4:                                                                                                                                                            
    SP5:                                                                                                                                                            

    ExUns: 23 ^ 24 ^ 25
    SP1:                  
    SP2:                  
    SP3:                  
    SP4:                  
    SP5:                  


    ECgene alternative splicing isoforms for AFF3

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    AFF3 expression in normal human tissues (normalized intensities)      AFF3 embryonic expression: see
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: TCTGCCTTTC
    AFF3 Expression
    About this image


    AFF3 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database 
     5/33 selected tissues (see all 33) fully expand
     
     Brain (Nervous System)    fully expand to see all 8 entries
             Endothelial Cells Blood Brain Barrier
             Cerebral Cortex
             Human Brain Vascular Smooth Muscle Cells (HBVSMC)   
             brain/midbrain   
     
     Cartilage (Muscoskeletal System)    fully expand to see all 6 entries
             Intervertebral Disc Annulus Fibrosus Cells Thoracic Intervertebral Disc
             Human Nucleus Pulposus Cells (HNPC)   
             skeleton/cranium   
     
     Lower Urinary Tract (Urinary System)    fully expand to see all 4 entries
             Ureter
             visceral organ   
     
     Neural Tube (Nervous System)    fully expand to see all 3 entries
             Metencephalon
     
     Neural Crest (Gastrulation Derivatives)    fully expand to see all 2 entries
             PureStem 4D20.8, NCr-fac Progenitor
             skeleton/cranium   

    See AFF3 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for AFF3

    SOURCE GeneReport for Unigene cluster: Hs.444414

    UniProtKB/Swiss-Prot: AFF3_HUMAN, P51826
    Tissue specificity: Preferentially expressed in lymphoid tissues, highest levels being found in the thymus

        SABiosciences Custom PCR Arrays for AFF3
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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for AFF3

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of animals.

    Orthologs for AFF3 gene from 5/12 species (see all 12)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Aff31 , 5 AF4/FMR2 family, member 31, 5 86.37(n)1
    88.75(a)1
      1 (16.58 cM)5
    167641  NM_010678.21  NP_034808.21 
     381773265 
    chicken
    (Gallus gallus)
    Aves AFF31 AF4/FMR2 family, member 3 73.92(n)
    72.1(a)
      418705  XM_001233771.2  XP_001233772.2 
    lizard
    (Anolis carolinensis)
    Reptilia AFF36
    Uncharacterized protein
    62(a)
    1 ↔ 1
    GL343456.1(158065-488154)
    zebrafish
    (Danio rerio)
    Actinopterygii AFF36
    AF4/FMR2 family, member 3
    24(a)
    1 ↔ 1
    9(22524163-22540428)
    fruit fly
    (Drosophila melanogaster)
    Insecta lilli6
    lilliputian
    13(a)
    1 → many
    2L(2885929-2954406)


    ENSEMBL Gene Tree for AFF3 (if available)
    TreeFam Gene Tree for AFF3 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for AFF3 gene
    AFF12  AFF22  AFF42  
    3 SIMAP similar genes for AFF3 using alignment to 12 protein entries:     AFF3_HUMAN (see all proteins):
    AFF4    AFF1    AFF2

    AFF3 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/11001 SNPs in AFF3 are shown (see all 11001)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 2 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    VAR_0308054
    ----see VAR_0308052 S N mis40--------
    rs1180850521,2
    C,F--100163311(+) GGCATC/TCCAGG 2 -- ds50011Minor allele frequency- T:0.07EA 120
    rs75710751,2
    C,F,H--100163432(+) cgcgcG/Atgtgt 2 -- ds50018Minor allele frequency- A:0.00NS EA NA 1066
    rs739641611,2
    C,F--100163493(+) TATAAT/CGAAGA 2 -- ds50012Minor allele frequency- C:0.11WA 120
    rs1845943571,2
    --100163572(+) CCATTA/TATGAA 2 -- ds50010--------
    rs1996035721,2
    C--100163608(+) CTGGG-/GAGCCA 2 -- ds50010--------
    rs1892367241,2
    --100163633(+) TTGAAC/TGTATT 2 -- ds50010--------
    rs67501391,2
    C,F,H--100163655(+) GTTTCC/TGTGTA 2 -- ds50014Minor allele frequency- T:0.01NS EA 418
    rs1154277011,2
    C--100163743(+) TAACAC/TTTGCA 2 -- ut310--------
    rs341228481,2
    C--100163958(+) CTTGC-/TTTTTT 2 -- ut310--------

    HapMap Linkage Disequilibrium report for AFF3 (100163715 - 100413715 bp, first 250kb of AFF3)

    Structural Variations
         Database of Genomic Variants (DGV) 10/14 variations for AFF3 (see all 14):    About this table     
    Variant IDTypeSubtypePubMed ID
    esv2720434CNV Deletion23290073
    esv2720433CNV Deletion23290073
    esv2137645CNV Deletion18987734
    esv2662354CNV Deletion23128226
    esv272467CNV Insertion20981092
    nsv2846CNV Insertion18451855
    nsv2848CNV Insertion18451855
    esv270786CNV Insertion20981092
    nsv527481CNV Loss19592680
    nsv2845CNV Loss18451855


    Human Gene Mutation Database (HGMD): AFF3
    SABiosciences Cancer Mutation PCR Assays
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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    OMIM gene information: 601464    OMIM disorders: --

    12 diseases for AFF3:    About MalaCards
    fibular aplasia    follicular lymphoma    lymphoblastic leukemia    intellectual disability
    acute lymphoblastic leukemia    type 1 diabetes    systemic lupus erythematosus    leukemia
    lupus erythematosus    rheumatoid arthritis    arthritis    breast cancer


    AFF3 for disorders           About GeneDecksing

    2 Novoseek inferred disease relationships for AFF3 gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    lymphoblastic leukemia acute 66.4 3 12743608 (1), 8555498 (1), 12203795 (1)
    leukemia 28.7 1 8555498 (1)

    Genetic Association Database (GAD): AFF3
    Human Genome Epidemiology (HuGE) Navigator: AFF3 (9 documents)

    Export disorders for AFF3 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for AFF3 gene, integrated from 9 sources (see all 37):
    (articles sorted by number of sources associating them with AFF3)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. LAF-4 encodes a lymphoid nuclear protein with transactivation potential that is homologous to AF-4, the gene fused to MLL in t(4;11) leukemias. (PubMed id 8555498)1, 2, 3, 9 Ma C. and Staudt L.M. (1996)
    2. Investigation of rheumatoid arthritis susceptibility genes identifies association of AFF3 and CD226 variants with response to anti-t umour necrosis factor treatment. (PubMed id 20444755)1, 4 Tan R.J....Barton A. (2010)
    3. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PubMed id 20379614)1, 4 Rose J.E....Uhl G.R. (2010)
    4. Genome-wide association study meta-analysis identifie s seven new rheumatoid arthritis risk loci. (PubMed id 20453842)1, 4 Stahl E.A....Plenge R.M. (2010)
    5. Association of the AFF3 gene and IL2/IL21 gene region with juvenile idiopathic arthritis. (PubMed id 20072139)1, 4 Hinks A....Thomson W. (2010)
    6. Investigation of potential non-HLA rheumatoid arthrit is susceptibility loci in a European cohort increases the evidence for nine mar kers. (PubMed id 20498205)1, 4 Plant D....Worthington J. (2010)
    7. Coeliac disease associated risk variants in TNFAIP3 and REL implicate altered NF-{kappa}B signalling. (PubMed id 19240061)1, 4 Trynka G....Wijmenga C. (2009)
    8. Robust associations of four new chromosome regions from genome-wide analyses of type 1 diabetes. (PubMed id 17554260)1, 4 Todd J.A.... Clayton D.G. (2007)
    9. Generation and annotation of the DNA sequences of human chromosomes 2 and 4. (PubMed id 15815621)1, 2 Hillier L.W....Wilson R.K. (2005)
    10. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 3899 HGNC: 6473 AceView: LAF4 Ensembl:ENSG00000144218 euGenes: HUgn3899
    ECgene: AFF3 H-InvDB: AFF3

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for AFF3 Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for AFF3 Genetics and Cytogenetics in Oncology and Haematology

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for AFF3 gene:
    Search GeneIP for patents involving AFF3

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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