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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

AFF3 Gene

protein-coding   GIFtS: 55
GCID: GC02M100163

AF4/FMR2 family, member 3

(Previous name: lymphoid nuclear protein related to AF4 )
(Previous symbol: LAF4)
 Explore 9 diseases affiliated with
AFF3 via
MalaCards
our new
 Human Malady Compendium 
Biological research products
for AFF3    

Aliases
for AFF3 gene

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, and/or 10fRNAdb)
About This Section
Aliases
AF4/FMR2 Family, Member 31 2     Protein LAF-42 3
LAF41 2 3 5     AF4/FMR2 Family Member 32
Lymphoid Nuclear Protein Related To AF41 2 3     Lymphoid Nuclear Protein 42
MLLT2-Like1     MLLT2-Related Protein2

External Ids:    HGNC: 64731   Entrez Gene: 38992   Ensembl: ENSG000001442187   OMIM: 6014645   UniProtKB: P518263   

Export aliases for AFF3 gene to outside databases

Previous GC identifers: GC02M099627 GC02M093928


Summaries
for AFF3 gene

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section
Entrez Gene summary for AFF3:
This gene encodes a tissue-restricted nuclear transcriptional activator that is preferentially expressed in lymphoid
tissue. Isolation of this protein initially defined a highly conserved LAF4/MLLT2 gene family of nuclear transcription
factors that may function in lymphoid development and oncogenesis. In some ALL patients, this gene has been found
fused to the gene for MLL. Multiple alternatively spliced transcript variants that encode different proteins have been
found for this gene. (provided by RefSeq, Jul 2008)

UniProtKB/Swiss-Prot: AFF3_HUMAN, P51826
Function: Putative transcription activator that may function in lymphoid development and oncogenesis. Binds, in vitro,
to double-stranded DNA

Gene Wiki entry for AFF3


Genomic Views
for AFF3 gene

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000002.11  NC_018913.1  NT_022171.15  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the AFF3 gene promoter:
         AML1a   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmids (see all 2): AFF3 promoter sequence
   Search SABiosciences Chromatin IP Primers for AFF3

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat AFF3


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 2q11.2-q12   Ensembl cytogenetic band:  2q11.2   HGNC cytogenetic band: 2q11.2-q12

AFF3 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
AFF3 gene location

GeneLoc information about chromosome 2         GeneLoc Exon Structure

GeneLoc location for GC02M100163:  view genomic region     (about GC identifiers)

Start:
 100,163,715 bp from pter      End:
 100,759,201 bp from pter
Size:
 595,487 bases      Orientation:
 minus strand

Proteins
for AFF3 gene

(According to 1UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to 2PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section
UniProtKB/Swiss-Prot: AFF3_HUMAN, P51826 (See protein sequence)
Recommended Name: AF4/FMR2 family member 3  
Size: 1226 amino acids; 133476 Da
Subcellular location: Nucleus
Secondary accessions: B7ZM46 B9EGL9 D3DVI6 Q53RD6 Q53S47 Q53SI6 Q53TB9 Q59F27 Q8IWJ5
Alternative splicing: 2 isoforms:  P51826-1   P51826-2   

Explore the universe of human proteins at neXtProt for AFF3: NX_P51826

Post-translational modifications:

  • View modification sites using PhosphoSitePlus2
  • View neXtProt modification sites for NX_P51826

    • AFF3 Protein expression data from MOPED and PaxDb:    About this image 
    Estimated protein expression log10 (pmol).

    REFSEQ proteins (2 alternative transcripts): 
    NP_001020279.1  NP_002276.2  

    ENSEMBL proteins: 
     ENSP00000386834   ENSP00000387207   ENSP00000416685   ENSP00000414099   ENSP00000406484  
     ENSP00000396582   ENSP00000399795   ENSP00000411383   ENSP00000395068   ENSP00000393732  
     ENSP00000407448   ENSP00000416131   ENSP00000317421   ENSP00000348793  

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    Uscn Proteins for AFF3

    Gene Ontology (GO): 2 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus IDA--
    GO:0005730nucleolus IDA--


    AFF3 for ontologies           About GeneDecksing



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    Uscn ELISAs and CLIAs for AFF3

    Protein Domains /
    Families
    for AFF3 gene

    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    AFF3 for domains           About GeneDecksing

    1 InterPro domain/family:
     IPR007797 TF_AF4/FMR2

    Graphical View of Domain Structure for InterPro Entry P51826

    ProtoNet protein and cluster: P51826

    1 Blocks protein family: IPB007797 AF-4 proto-oncoprotein

    UniProtKB/Swiss-Prot: AFF3_HUMAN, P51826
    Similarity: Belongs to the AF4 family


    Function
    for AFF3 gene

    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
    About This Section
    Function Summary:

         UniProtKB/Swiss-Prot: AFF3_HUMAN, P51826
    Function: Putative transcription activator that may function in lymphoid development and oncogenesis. Binds, in vitro,
    to double-stranded DNA

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    In Situ Assay
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    Gene Ontology (GO): 1 molecular function term (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003690double-stranded DNA binding IDA8555498


    AFF3 for ontologies           About GeneDecksing


    1 GenomeRNAi human phenotype for AFF3:
     Increased gamma-H2AX phosphory 

    Animal Models:
         1 MGI mutant phenotype (inferred from 1 allele) (MGI details for Aff3):
     skeleton 

    AFF3 for phenotypes           About GeneDecksing


    Pathways & Interactions
    for AFF3 gene

    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
    About This Section



    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for AFF3

    STRING Interaction Network Preview (showing 1 interactants - click image to see more details)

    4 Interacting proteins for AFF3 (P518263 ENSP000003487934) via UniProtKB, MINT, STRING, and/or I2D
    InteractantInteraction Details
    GeneCardExternal ID(s)
    MLLT3P425683, ENSP000003696954I2D: score=1 STRING: ENSP00000369695
    PTK2Q053973I2D: score=2 
    WNK1Q9H4A33I2D: score=2 
    IRS1P355683I2D: score=1 
    About this table

    Gene Ontology (GO): 4 biological process terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006351transcription, DNA-dependent IEA--
    GO:0006355regulation of transcription, DNA-dependent IEA--
    GO:0034612response to tumor necrosis factor IMP--
    GO:0035116embryonic hindlimb morphogenesis IMP18616733


    AFF3 for ontologies           About GeneDecksing



    Drugs & Compounds
    for AFF3 gene

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for AFF3
    Search CenterWatch for drugs/clinical trials and news about AFF3 

    Transcripts
    for AFF3 gene

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section
    REFSEQ mRNAs for AFF3 gene (2 alternative transcripts): 
    NM_001025108.1  NM_002285.2  

    Unigene Cluster for AFF3:

    AF4/FMR2 family, member 3
    Hs.444414  [show with all ESTs]
    Unigene Representative Sequence: NM_002285
    16 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000409579(uc010fir.1 uc010yvr.1 uc002tah.1) ENST00000409236(uc010fiq.1)
    ENST00000445815 ENST00000430789 ENST00000498090 ENST00000432037 ENST00000423966
    ENST00000441400 ENST00000424600 ENST00000416492 ENST00000440445 ENST00000415384
    ENST00000427118 ENST00000483600 ENST00000317233(uc002tag.3) ENST00000356421(uc002taf.3)


    miRNA
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    hsa-miR-411* hsa-miR-576-3p hsa-miR-134 hsa-miR-1260b hsa-miR-4305 hsa-miR-128 hsa-miR-4275 hsa-miR-1273d
    SwitchGear 3'UTR luciferase reporter plasmid: AFF3 3' UTR sequence
    Inhib. RNA
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    Clone
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    Primer
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      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat AFF3

    Additional cDNA sequence: 

    AB209634.1 AK055117.1 AK091320.1 AK092327.1 AK290468.1 AK297407.1 AK308645.1 AL832702.1 
    BC021283.2 BC036895.1 BC136579.1 BC144266.1 U34360.1 

    12 DOTS entries:

    DT.445740  DT.213449  DT.86837483  DT.120972230  DT.431851  DT.95262874  DT.120972389  DT.92417628 
    DT.99978926  DT.120972330  DT.120972443  DT.75174244 

    24/62 AceView cDNA sequences (see all 62):

    BC036895 CR596530 AI381467 AL704329 BI829437 AW183638 AW134639 AW172512 
    AW575892 BE646040 CB409656 CD614446 AW502665 AL601353 BU929881 AU118377 
    AX747484 AW167756 AW576594 AI990465 T07191 AW505312 BQ216011 U34360 

    GeneLoc Exon Structure

    5 Alternative Splicing Database (ASD) splice patterns (SP) for AFF3    About this scheme

    ExUns: 1 ^ 2 ^ 3a · 3b ^ 4 ^ 5 ^ 6a · 6b ^ 7 ^ 8 ^ 9 ^ 10 ^ 11 ^ 12 ^ 13 ^ 14 ^ 15a · 15b ^ 16a · 16b ^ 17 ^ 18 ^ 19 ^ 20 ^ 21 ^ 22 ^
    SP1:                          -                                                                                                                                 
    SP2:                                                                                                                    -                                       
    SP3:                                                                                                                                                            
    SP4:                                                                                                                                                            
    SP5:                                                                                                                                                            

    ExUns: 23 ^ 24 ^ 25
    SP1:                  
    SP2:                  
    SP3:                  
    SP4:                  
    SP5:                  


    ECgene alternative splicing isoforms for AFF3

    Expression
    for AFF3 gene

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    AFF3 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS
    CGAP TAG: TCTGCCTTTC

    Microarray
    RNAseq (Illumina Body Map)
    (100×FPKM)½
    SAGE (Serial Analysis of Gene Expression)
    About this image

    AFF3 expression in embryonic tissues and stem cells
    Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine    About this table
    8 LifeMap In Vivo Development Anatomical Compartments/Cells 
    Tissue Anatomical Compartment CellCategory (developmental path)
    CartilageCervical Intervertebral DiscIntervertebral Disc Annulus Fibrosus CellsCartilage
    CartilageLumbar Intervertebral DiscIntervertebral Disc Annulus Fibrosus CellsCartilage
    CartilageSacral Intervertebral DiscIntervertebral Disc Annulus Fibrosus CellsCartilage
    CartilageThoracic Intervertebral DiscIntervertebral Disc Annulus Fibrosus CellsCartilage
    OvaryAntral FollicleCumulus CellsOvary
    KidneyMetanephrosKidney
    Lower Urinary TractUreterLower Urinary Tract
    Reproductive SystemMesonephrosReproductive System
    Expression: Positive    Negative     Selective marker
    Experimental details: Curated     Microarrays     In-situ hybridization
    Stem Cell Differentiation: 5 LifeMap Cells 
    NameCategory
    PureStem™ mesenchymal progenitor 7SMOO32 (Embryonic Progenitor Cell)Adipose, Bone, Cartilage
    PureStem™ mesenchymal progenitor 4D20.8 (Embryonic Progenitor Cell)Lateral Plate Mesoderm, Neural Crest
    PureStem™ mesenchymal progenitor E15 (Embryonic Progenitor Cell)Adipose, Bone, Cartilage
    PureStem™ progenitor E69 (Embryonic Progenitor Cell)
    Pancreatic endoderm/endocrine precursor-like cells (A scalable, suspensi...)

    See AFF3 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for AFF3

    SOURCE GeneReport for Unigene cluster: Hs.444414

    UniProtKB/Swiss-Prot: AFF3_HUMAN, P51826
    Tissue specificity: Preferentially expressed in lymphoid tissues, highest levels being found in the thymus

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    In Situ
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    Orthologs
    for AFF3 gene

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section
    This gene was present in the common ancestor of animals.

    Orthologs for AFF3 gene from 4/15 species (see all 15)    About this table
    Organism Taxonomic
    classification    		 Gene Description Human
    Similarity    		 Orthology
    Type    		 Details
    chicken
    (Gallus gallus)    		 Aves AFF31 AF4/FMR2 family, member 3 73.92(n)
    72.1(a)    		   418705  XM_001233771.2  XP_001233772.2 
    lizard
    (Anolis carolinensis)    		 Reptilia --
    --
    		 --
    		 59(a)
    53(a)
    		 1 ↔ many
    1 ↔ many
    		 GL343456.1(158065-183960)
    GL343456.1(433910-438447)
    zebrafish
    (Danio rerio)    		 Actinopterygii si:dkey-19j7.26
    		 si:dkey-19j7.2
    		 24(a)
    		 1 ↔ 1
    		 9(22524163-22540428)
    fruit fly
    (Drosophila melanogaster)    		 Insecta lilli6
    		 lilliputian
    		 12(a)
    		 1 → many
    		 2L(2885929-2954406)


    ENSEMBL Gene Tree for AFF3 (if available)
    TreeFam Gene Tree for AFF3 (if available) 

    Paralogs
    for AFF3 gene

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for AFF3 gene
    AFF12  AFF22  AFF42  
    4 SIMAP similar genes for AFF3 using alignment to 12 protein entries:     AFF3_HUMAN (see all proteins):
    AFF4    AFF1    AFF2    AF-4

    AFF3 for paralogs           About GeneDecksing



    Genomic Variants
    for AFF3 gene

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/9194 NCBI SNPs in AFF3 are shown (see all 9194)     About this table
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance    		Chr 2 posSequence#AA
    Chg    		TypeMore#Allele
    freq    		PopTotal
    sample    		More
    ----------
    rs1180850521,2
    		F,--100163311(+) GGCATC/TCCAGG 2 -- ds50011Minor allele frequency- T:0.07EA 120
    rs75710751,2
    		C,F,H,--100163432(+) CGCGCG/ATGTGT 2 -- ds50018Minor allele frequency- A:0.00NS EA NA 1066
    rs739641611,2
    		C,--100163493(+) TATAAT/CGAAGA 2 -- ds50012Minor allele frequency- C:0.11WA 120
    rs1845943571,2
    		--100163572(+) CCATTA/TATGAA 2 -- ds50010--------
    rs1996035721,2
    		--100163608(+) AAACT-/GGGGAG 2 -- ds50010--------
    rs1892367241,2
    		--100163633(+) TTGAAC/TGTATT 2 -- ds50010--------
    rs67501391,2
    		C,F,H,--100163655(+) GTTTCC/TGTGTA 2 -- ds50014Minor allele frequency- T:0.01NS EA 418
    rs1154277011,2
    		C,--100163743(+) TAACAC/TTTGCA 2 -- ut310--------
    rs341228481,2
    		C--100163958(+) CTTGC-/TTTTTT 2 -- ut310--------
    rs1453414961,2
    		--100164093(+) ACTGAC/TTAATT 2 -- ut310--------

    HapMap Linkage Disequilibrium report for AFF3 (100163715 - 100413715 bp, first 250kb of AFF3)
    Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
    Database of Genomic Variants (DGV): 2 variations for AFF3
         1 CNV: 3379
         1 Indel: 60312
    Human Gene Mutation Database (HGMD): AFF3

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    Disorders / Diseases
    for AFF3 gene

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    AFF3 for disorders           About GeneDecksing

    OMIM gene information: 601464    OMIM disorders: --

    9 diseases for AFF3:    About MalaCards
    fibular aplasia    lymphoblastic leukemia    intellectual disability    acute lymphoblastic leukemia
    rheumatoid arthritis    follicular lymphoma    arthritis    leukemia
    breast cancer

    2 Novoseek disease relationships for AFF3 gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    lymphoblastic leukemia acute 66.4 3 12743608 (1), 8555498 (1), 12203795 (1)
    leukemia 28.7 1 8555498 (1)

    Human Genome Epidemiology (HuGE) Navigator: AFF3 (9 documents)

    Export disorders for AFF3 gene to outside databases

    Publications
    for AFF3 gene

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for AFF3 gene, integrated from 9 sources (see all 31):
    (articles sorted by number of sources associating them with AFF3)    		    Utopia: connect your pdf to the dynamic
    world of online information

    1. LAF-4 encodes a lymphoid nuclear protein with transactivation potential that is homologous to AF-4, the gene fused to MLL in t(4;11) leukemias. (PubMed id 8555498)1, 2, 3, 9 Ma C. and Staudt L.M. (1996)
    2. Generation and annotation of the DNA sequences of human chromosomes 2 and 4. (PubMed id 15815621)1, 2 Hillier L.W....Wilson R.K. (2005)
    3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    4. LAF4 maps to mouse chromosome 1 and human chromosome 2q11.2-q12. (PubMed id 8662235)1, 3 Liao X....Copeland N.G. (1996)
    5. Fusion of an AF4-related gene, LAF4, to MLL in childhood acute lymphoblastic leukemia with t(2;11)(q11;q23). (PubMed id 12743608)1, 9 Hiwatari M....Hayashi Y. (2003)
    6. LAF4, an AF4-related gene, is fused to MLL in infant acute lymphoblastic leukemia. (PubMed id 12203795)1, 9 von Bergh A.R....Schuuring E. (2002)
    7. Association of AFF1 rs340630 and AFF3 rs10865035 polym orphisms with systemic lupus erythematosus in a Chinese population. (PubMed id 22983539)1 Cen H....Ye D.Q. (2012)
    8. Functional characterization of the AFF (AF4/FMR2) fam ily of RNA-binding proteins: insights into the molecular pathology of FRAXE int ellectual disability. (PubMed id 21330300)1 Melko M....Bardoni B. (2011)
    9. MLL-AF9 and MLL-ENL alter the dynamic association of transcriptional regulators with genes critical for leukemia. (PubMed id 20854876)1 Monroe S.C....Hess J.L. (2011)
    10. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PubMed id 20379614)1 Rose J.E....Uhl G.R. (2010)

    External Searches for AFF3 gene

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Disorders
    Free Text  
      Query String
    		PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    Genome Databases showing AFF3 gene

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 3899 HGNC: 6473 AceView: LAF4 Ensembl:ENSG00000144218 euGenes: HUgn3899
    ECgene: AFF3 H-InvDB: AFF3

    Other Databases showing AFF3 gene

    (According to HUGE)
    About This Section
    		   --

    Specialized Databases showing AFF3 gene

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for AFF3 Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for AFF3 Genetics and Cytogenetics in Oncology and Haematology

    Intellectual Property
    for AFF3 gene

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    		Patent Information for AFF3 gene:
    Search GeneIP for patents involving AFF3

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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