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AFAP1L2 Gene

protein-coding   GIFtS: 56
GCID: GC10M116045

Actin Filament Associated Protein 1-Like 2

(Previous name: KIAA1914)
(Previous symbol: KIAA1914)
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(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Actin Filament Associated Protein 1-Like 21 2
KIAA19141 2 3 5
XB1302 3 5
AFAP1-Like Protein 22 3
Actin Filament-Associated Protein 1-Like 22

External Ids:    HGNC: 259011   Entrez Gene: 846322   Ensembl: ENSG000001691297   OMIM: 6124205   UniProtKB: Q8N4X53   

Export aliases for AFAP1L2 gene to outside databases

Previous GC identifer: GC10M109682


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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GeneCards Summary for AFAP1L2 Gene:
AFAP1L2 (actin filament associated protein 1-like 2) is a protein-coding gene. Diseases associated with AFAP1L2 include noma, and thyroid cancer. GO annotations related to this gene include phospholipid binding and SH2 domain binding. An important paralog of this gene is AFAP1.

UniProtKB/Swiss-Prot: AF1L2_HUMAN, Q8N4X5
Function: May play a role in a signaling cascade by enhancing the kinase activity of SRC. Contributes to
SRC-regulated transcription activation




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence:
NC_000010.11  NT_030059.14  NC_018921.2  
Regulatory elements:
   Search for regulatory transcription factor binding sites for AFAP1L2
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidAFAP1L2 promoter sequence
   Search Chromatin IP Primers for AFAP1L2

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat AFAP1L2


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 10q25.3   Ensembl cytogenetic band:  10q25.3   HGNC cytogenetic band: 10q26.11

AFAP1L2 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
AFAP1L2 gene location

GeneLoc information about chromosome 10         GeneLoc Exon Structure

GeneLoc location for GC10M116045:  view genomic region     (about GC identifiers)

Start:
116,054,583 bp from pter      End:
116,164,515 bp from pter
Size:
109,933 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
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UniProtKB/Swiss-Prot: AF1L2_HUMAN, Q8N4X5 (See protein sequence)
Recommended Name: Actin filament-associated protein 1-like 2  
Size: 818 amino acids; 91300 Da
Subunit: Interacts with SRC. Interacts with LCK when tyrosine phosphorylated
Sequence caution: Sequence=BAB67807.1; Type=Erroneous initiation;
1 PDB 3D structure from and Proteopedia for AFAP1L2:
2COF (3D)    
Secondary accessions: A8K6P7 B3KVQ8 Q2UZW3 Q8TB54 Q96PX4 Q96SY5
Alternative splicing: 4 isoforms:  Q8N4X5-1   Q8N4X5-2   Q8N4X5-3   Q8N4X5-4   

Explore the universe of human proteins at neXtProt for AFAP1L2: NX_Q8N4X5

Explore proteomics data for AFAP1L2 at MOPED

Post-translational modifications: 

  • Tyrosine phosphorylated (by SRC)1
  • Modification sites at neXtProt
  • Modification sites at PhosphoSitePlus

  • See AFAP1L2 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (3 alternative transcripts): 
    NP_001001936.1  NP_001274753.1  NP_115939.1  

    ENSEMBL proteins: 
     ENSP00000303042   ENSP00000358276   ENSP00000396781   ENSP00000444511  

    AFAP1L2 Human Recombinant Protein Products:

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    AFAP1L2 Antibody Products:

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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    PLEKH: Pleckstrin homology (PH) domain containing

    2 InterPro protein domains:
     IPR001849 Pleckstrin_homology
     IPR011993 PH_like_dom

    Graphical View of Domain Structure for InterPro Entry Q8N4X5

    ProtoNet protein and cluster: Q8N4X5

    1 Blocks protein domain: IPB001849 Pleckstrin-like

    UniProtKB/Swiss-Prot: AF1L2_HUMAN, Q8N4X5
    Similarity: Contains 2 PH domains


    AFAP1L2 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: AF1L2_HUMAN, Q8N4X5
    Function: May play a role in a signaling cascade by enhancing the kinase activity of SRC. Contributes to
    SRC-regulated transcription activation

         Gene Ontology (GO): 3 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0017124SH3 domain binding IPI17412687
    GO:0030296protein tyrosine kinase activator activity IDA17412687
    GO:0042169SH2 domain binding IPI17412687
         
    AFAP1L2 for ontologies           About GeneDecksing


    Phenotypes:
         4 GenomeRNAi human phenotypes for AFAP1L2:
     Decreased melanin production  Increased S DNA content  Increased cell number in G1, s  Increased gamma-H2AX phosphory 

         1 MGI phenotypic allele for Afap1l2 (no phenotypes)

    AFAP1L2 for phenotypes           About GeneDecksing

    Animal Models:
       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for AFAP1L2
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    miRNA
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    miRTarBase miRNAs that target AFAP1L2:
    hsa-mir-34a-5p (MIRT025412)

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    Selected qRT-PCR Assays for microRNAs that regulate AFAP1L2 (see all 20):
    hsa-miR-30c hsa-miR-3607-3p hsa-miR-30d hsa-miR-219-5p hsa-miR-373* hsa-miR-374c hsa-miR-30a hsa-miR-924
    SwitchGear 3'UTR luciferase reporter plasmidAFAP1L2 3' UTR sequence
    Inhib. RNA
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    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    AF1L2_HUMAN, Q8N4X5: Cytoplasm
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    nucleus4
    plasma membrane4
    cytosol3

    Gene Ontology (GO): 4 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus ----
    GO:0005737cytoplasm IDA17412687
    GO:0005886plasma membrane ----
    GO:0016235aggresome ----

    AFAP1L2 for ontologies           About GeneDecksing


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for AFAP1L2 About    
    See pathways by source

    SuperPathContained pathways About
    1Cytoskeletal Signaling
    Cytoskeletal Signaling

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways


    1 Cell Signaling Technology (CST) Pathway for AFAP1L2
        Cytoskeletal Signaling



    AFAP1L2 for pathways           About GeneDecksing

        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for AFAP1L2
    Interactions:

        Search GeneGlobe Interaction Network for AFAP1L2

    STRING Interaction Network Preview (showing 5 interactants - click image to see 7)

    Selected Interacting proteins for AFAP1L2 (Q8N4X52, 3 ENSP000003030424) via UniProtKB, MINT, STRING, and/or I2D (see all 8)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    RASA1P209363, ENSP000002743764I2D: score=1 STRING: ENSP00000274376
    SRCP129313, ENSP000003509414I2D: score=1 STRING: ENSP00000350941
    ACDENSP000003774964STRING: ENSP00000377496
    POT1ENSP000003502494STRING: ENSP00000350249
    TERF1ENSP000002766034STRING: ENSP00000276603
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 7):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006954inflammatory response IDA17412687
    GO:0007346regulation of mitotic cell cycle IDA17412687
    GO:0032675regulation of interleukin-6 production IDA17412687
    GO:0032757positive regulation of interleukin-8 production IDA17412687
    GO:0045742positive regulation of epidermal growth factor receptor signaling pathway IDA17412687

    AFAP1L2 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for AFAP1L2 (AF1L2)



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
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    REFSEQ mRNAs for AFAP1L2 gene (3 alternative transcripts): 
    NM_001001936.2  NM_001287824.1  NM_032550.3  

    Unigene Cluster for AFAP1L2:

    Actin filament associated protein 1-like 2
    Hs.501106  [show with all ESTs]
    Unigene Representative Sequence: NM_001001936
    7 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000304129(uc001lbm.3 uc010qsd.2) ENST00000369271(uc001lbn.3 uc001lbo.3 uc010qse.2 uc001lbp.3 uc001lbr.1)
    ENST00000491814(uc001lbq.1) ENST00000486300 ENST00000419268 ENST00000483496
    ENST00000545353

    miRNA
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    Selected qRT-PCR Assays for microRNAs that regulate AFAP1L2 (see all 20):
    hsa-miR-30c hsa-miR-3607-3p hsa-miR-30d hsa-miR-219-5p hsa-miR-373* hsa-miR-374c hsa-miR-30a hsa-miR-924
    SwitchGear 3'UTR luciferase reporter plasmidAFAP1L2 3' UTR sequence
    Inhib. RNA
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      QuantiTect SYBR Green Assays in human, mouse, rat AFAP1L2
      QuantiFast Probe-based Assays in human, mouse, rat AFAP1L2

    Additional mRNA sequence: 

    AB067501.1 AF474151.1 AK123108.1 AK291712.1 AK294969.1 AK295538.1 BC016403.1 BC024314.1 
    BC033212.1 BC035713.1 

    12 DOTS entries:

    DT.444461  DT.101981461  DT.100786979  DT.102828116  DT.210446  DT.95160952  DT.99968703  DT.100698484 
    DT.121270727  DT.97842381  DT.100753165  DT.100836972 

    Selected AceView cDNA sequences (see all 93):

    AI493714 CK300428 BC033212 AI658698 BM561567 AW006448 AI420121 BP342007 
    CR595409 AB067501 CO245655 AK123108 F01902 CD515315 BC016403 BE645538 
    AA404497 NM_032550 NM_001001936 AA570115 BM918355 BX280240 Z38874 AI420374 

    GeneLoc Exon Structure

    Selected Alternative Splicing Database (ASD) splice patterns (SP) for AFAP1L2 (see all 11)    About this scheme

    ExUns: 1a · 1b ^ 2 ^ 3 ^ 4 ^ 5a · 5b ^ 6a · 6b ^ 7 ^ 8 ^ 9a · 9b · 9c ^ 10a · 10b ^ 11 ^ 12 ^ 13 ^ 14a · 14b ^ 15 ^ 16a · 16b ^ 17a · 17b ^
    SP1:              -     -           -                             -                                                     -                 -                     
    SP2:              -     -           -                             -                                                     -                 -                     
    SP3:                                -                                                                                   -                 -                     
    SP4:              -     -           -                             -                                                     -                 -                     
    SP5:                    -           -                             -                                                                                             

    ExUns: 18 ^ 19a · 19b ^ 20a · 20b ^ 21 ^ 22a · 22b · 22c
    SP1:                          -                           
    SP2:                                                      
    SP3:                          -                           
    SP4:                                                      
    SP5:                                                      


    ECgene alternative splicing isoforms for AFAP1L2

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    AFAP1L2 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: AGTTTTGAGA
    AFAP1L2 Expression
    About this image


    AFAP1L2 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 4) fully expand
     
     Brain (Nervous System)    fully expand to see all 2 entries
             Oligodendrocyte Precursor Cells Forebrain White Matter
     
     Thyroid (Endocrine System)
     
     Placenta (Extraembryonic Tissues)
     
     Spleen (Hematopoietic System)
    AFAP1L2 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    AFAP1L2 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.501106

    UniProtKB/Swiss-Prot: AF1L2_HUMAN, Q8N4X5
    Tissue specificity: Detected in spleen and thyroid, and at lower levels in kidney, brain, lung and pancreas

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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for AFAP1L2

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of chordates.

    Orthologs for AFAP1L2 gene from Selected species (see all 12)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Afap1l21 , 5 actin filament associated protein 1-like 21, 5 84.11(n)1
    83.5(a)1
      19 (52.04 cM)5
    2262501  NM_001177796.11  NP_001171267.11 
     569123615 
    chicken
    (Gallus gallus)
    Aves AFAP1L21 actin filament associated protein 1-like 2 69.82(n)
    70.89(a)
      423908  XM_004942292.1  XP_004942349.1 
    lizard
    (Anolis carolinensis)
    Reptilia AFAP1L26
    actin filament associated protein 1-like 2
    67(a)
    1 ↔ 1
    GL344115.1(1056-62995)
    African clawed frog
    (Xenopus laevis)
    Amphibia BC057722.12   -- 80.17(n)    BC057722.1 
    zebrafish
    (Danio rerio)
    Actinopterygii afap1l21 actin filament associated protein 1-like 2 59.83(n)
    56.12(a)
      567369  XM_005156257.1  XP_005156314.1 


    ENSEMBL Gene Tree for AFAP1L2 (if available)
    TreeFam Gene Tree for AFAP1L2 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for AFAP1L2 gene
    AFAP12  AFAP1L12  
    1 SIMAP similar gene for AFAP1L2 using alignment to 3 protein entries:     AF1L2_HUMAN (see all proteins):
    AFAP1

    AFAP1L2 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for AFAP1L2 (see all 2568)    About this table    
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 10 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs669762571,2
    C--109699006(+) GCAGA-/GT/GTGTG
    TGTGTGTGTGT
    GTGTG
    2 -- int11NA 2
    rs106272311,2
    C--116054775(+) GTGtt-/A/AA  
            
    aaaaa
    4 -- ut31 trp30--------
    rs1915853091,2
    --116054854(+) GAGGGC/TGATCA 2 -- ut310--------
    rs1843741171,2
    --116054858(+) GCGATA/CACCCT 2 -- ut310--------
    rs1492924951,2
    --116054897(+) AGGAGA/GATGAA 2 -- ut310--------
    rs283721301,2
    C--116054954(+) TTCCCT/CTAAAA 2 -- ut31 ese3 trp31Minor allele frequency- C:0.00NA 2
    rs1896583631,2
    --116055064(+) TGACAA/GGATTT 2 -- ut310--------
    rs1447524301,2
    C--116055069(+) GGATTG/TTAAGC 2 -- ut310--------
    rs1479014151,2
    C--116055237(+) TCATA-/GATGGT
    TTTACAGAT
    GATGG
    2 -- cds10--------
    rs1125358681,2
    C--116055282(+) TGTTT-/AAAAAT 2 -- ut311Minor allele frequency- A:0.50CSA 2

    HapMap Linkage Disequilibrium report for AFAP1L2 (116054583 - 116164515 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 4 variations for AFAP1L2:    About this table    
    Variant IDTypeSubtypePubMed ID
    esv2741173CNV Deletion23290073
    esv2741162CNV Deletion23290073
    dgv826n71CNV Loss21882294
    nsv7211OTHER Inversion18451855

    Site Specific Mutation Identification with PCR Assays
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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 612420    OMIM disorders: --

    8 diseases for AFAP1L2:    
    About MalaCards
    noma    thyroid cancer    thyroiditis    ataxia
    alzheimer's disease    colorectal cancer    hepatocellular carcinoma    neuronitis


    AFAP1L2 for disorders           About GeneDecksing


    Congresses - knowledge worth sharing:
    Alzheimer's & Parkinson's Diseases Congress (ADPD) 18 - 22 March 2015
    Genetic Association Database (GAD): AFAP1L2
    Human Genome Epidemiology (HuGE) Navigator: AFAP1L2 (2 documents)

    Export disorders for AFAP1L2 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

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    PubMed articles for AFAP1L2 gene, integrated from 10 sources (see all 24):
    (articles sorted by number of sources associating them with AFAP1L2)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. XB130, a novel adaptor protein for signal transduction. (PubMed id 17412687)1, 2, 3 Xu J.... Liu M. (J. Biol. Chem. 2007)
    2. Prediction of the coding sequences of unidentified human genes. XXI. The complete sequences of 60 new cDNA clones from brain which code for large proteins. (PubMed id 11572484)1, 2, 3 Nagase T.... Ohara O. (DNA Res. 2001)
    3. Common genetic variation and performance on standardized cognitive tests. (PubMed id 20125193)1, 4 Cirulli E.T....Goldstein D.B. (Eur. J. Hum. Genet. 2010)
    4. Human variation in alcohol response is influenced by variation in neuronal signaling genes. (PubMed id 20201926)1, 4 Joslyn G....White R.L. (Alcohol. Clin. Exp. Res. 2010)
    5. A scan of chromosome 10 identifies a novel locus showing strong association with late-onset Alzheimer disease. (PubMed id 16385451)1, 4 Grupe A....Goate A. (Am. J. Hum. Genet. 2006)
    6. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    7. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (Nat. Genet. 2004)
    8. The DNA sequence and comparative analysis of human chromosome 10. (PubMed id 15164054)1, 2 Deloukas P.... Rogers J. (Nature 2004)
    9. XB130 as an independent prognostic factor in human esophageal squamous cell carcinoma. (PubMed id 22805860)1 Shiozaki A....Otsuji E. (Ann. Surg. Oncol. 2013)
    10. XB130, a new adaptor protein, regulates expression of tumor suppressive microRNAs in cancer cells. (PubMed id 23527086)1 Takeshita H....Liu M. (PLoS ONE 2013)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section

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    Entrez Gene: 84632 HGNC: 25901 AceView: KIAA1914 Ensembl:ENSG00000169129 euGenes: HUgn84632
    ECgene: AFAP1L2 H-InvDB: AFAP1L2

    (According to HUGE)
    About This Section

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    HUGE: KIAA1914

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
    About This Section

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    NameDescription
    PharmGKB entry for AFAP1L2 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section

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    Patent Information for AFAP1L2 gene:
    Search GeneIP for patents involving AFAP1L2

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript, and ESI BIO, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
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