Set Analyses:
Advanced Search

Advanced Search

 
Search By
Section (entire)
for


 
or upload a file of gene symbols


Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

AFAP1L2 Gene

protein-coding   GIFtS: 56
GCID: GC10M116045

Actin Filament Associated Protein 1-Like 2

(Previous name: KIAA1914)
(Previous symbol: KIAA1914)
Alzheimer's & Parkinson's Diseases Congress
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
Actin Filament Associated Protein 1-Like 21 2
KIAA19141 2 3 5
XB1302 3 5
AFAP1-Like Protein 22 3
CTB-1144G6.42
Actin Filament-Associated Protein 1-Like 22

External Ids:    HGNC: 259011   Entrez Gene: 846322   Ensembl: ENSG000001691297   OMIM: 6124205   UniProtKB: Q8N4X53   

Export aliases for AFAP1L2 gene to outside databases

Previous GC identifer: GC10M109682


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

GeneCards Summary for AFAP1L2 Gene: 
AFAP1L2 (actin filament associated protein 1-like 2) is a protein-coding gene. Diseases associated with AFAP1L2 include noma, and thyroid cancer. GO annotations related to this gene include phospholipid binding and SH2 domain binding. An important paralog of this gene is AFAP1.

UniProtKB/Swiss-Prot: AF1L2_HUMAN, Q8N4X5
Function: May play a role in a signaling cascade by enhancing the kinase activity of SRC. Contributes to
SRC-regulated transcription activation




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000010.10  NT_030059.13  NC_018921.2  
Regulatory elements:
   Search SABiosciences Regulatory transcription factor binding sites for AFAP1L2
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidAFAP1L2 promoter sequence
   Search SABiosciences Chromatin IP Primers for AFAP1L2

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat AFAP1L2


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 10q25.3   Ensembl cytogenetic band:  10q25.3   HGNC cytogenetic band: 10q26.11

AFAP1L2 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
AFAP1L2 gene location

GeneLoc information about chromosome 10         GeneLoc Exon Structure

GeneLoc location for GC10M116045:  view genomic region     (about GC identifiers)

Start:
116,054,583 bp from pter      End:
116,164,515 bp from pter
Size:
109,933 bases      Orientation:
minus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: AF1L2_HUMAN, Q8N4X5 (See protein sequence)
Recommended Name: Actin filament-associated protein 1-like 2  
Size: 818 amino acids; 91300 Da
Subunit: Interacts with SRC. Interacts with LCK when tyrosine phosphorylated
Subcellular location: Cytoplasm
Sequence caution: Sequence=BAB67807.1; Type=Erroneous initiation;
1 PDB 3D structure from and Proteopedia for AFAP1L2:
2COF (3D)    
Secondary accessions: A8K6P7 B3KVQ8 Q2UZW3 Q8TB54 Q96PX4 Q96SY5
Alternative splicing: 4 isoforms:  Q8N4X5-1   Q8N4X5-2   Q8N4X5-3   Q8N4X5-4   

Explore the universe of human proteins at neXtProt for AFAP1L2: NX_Q8N4X5

Explore proteomics data for AFAP1L2 at MOPED 

Post-translational modifications:

  • UniProtKB: Tyrosine phosphorylated (by SRC)
  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_Q8N4X5

  • AFAP1L2 Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    AFAP1L2 Protein Expression
    REFSEQ proteins (2 alternative transcripts): 
    NP_001001936.1  NP_115939.1  

    ENSEMBL proteins: 
     ENSP00000303042   ENSP00000358276   ENSP00000396781   ENSP00000444511  

    Human Recombinant Protein Products for AFAP1L2: 
    Browse Purified and Recombinant Proteins at EMD Millipore
    Browse R&D Systems for human recombinant proteins
    Browse recombinant and purified proteins available from Enzo Life Sciences
    OriGene Purified Proteins for AFAP1L2
    OriGene Protein Over-expression Lysate for AFAP1L2
    OriGene MassSpec for AFAP1L2 
    OriGene Custom Protein Services for AFAP1L2
    GenScript Custom Purified and Recombinant Proteins Services for AFAP1L2
    Novus Biologicals AFAP1L2 Proteins
    Novus Biologicals AFAP1L2 Lysates
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates 
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for AFAP1L2 

    Gene Ontology (GO): 4 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus IDA--
    GO:0005737cytoplasm IDA--
    GO:0005886plasma membrane IDA--
    GO:0016235aggresome IDA--

    AFAP1L2 for ontologies           About GeneDecksing



    AFAP1L2 Antibody Products: 
    EMD Millipore Mono- and Polyclonal Antibodies for the study of AFAP1L2
    Browse R&D Systems for Antibodies
    Cell Signaling Technology (CST) Antibodies for AFAP1L2 
    OriGene Antibodies for AFAP1L2
    OriGene Custom Antibody Services for AFAP1L2
    GenScript Custom Superior Antibodies Services for AFAP1L2
    Novus Biologicals AFAP1L2 Antibodies
    Abcam antibodies for AFAP1L2
    Cloud-Clone Corp. Antibodies for AFAP1L2 
    ThermoFisher Antibodies for AFAP1L2
    LSBio Antibodies in human, mouse, rat for AFAP1L2 

    Assay Products for AFAP1L2: 
    Browse Kits and Assays available from EMD Millipore
    OriGene Custom Assay Services for AFAP1L2
    Browse R&D Systems for biochemical assays
    GenScript Custom Assay Services for AFAP1L2
    Browse Enzo Life Sciences for kits & assays
    Cloud-Clone Corp. ELISAs for AFAP1L2 
    Cloud-Clone Corp. CLIAs for AFAP1L2


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    HGNC Gene Families: 
    PLEKH: Pleckstrin homology (PH) domain containing

    2 InterPro protein domains:
     IPR001849 Pleckstrin_homology
     IPR011993 PH_like_dom

    Graphical View of Domain Structure for InterPro Entry Q8N4X5

    ProtoNet protein and cluster: Q8N4X5

    1 Blocks protein domain: IPB001849 Pleckstrin-like

    UniProtKB/Swiss-Prot: AF1L2_HUMAN, Q8N4X5
    Similarity: Contains 2 PH domains


    AFAP1L2 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: AF1L2_HUMAN, Q8N4X5
    Function: May play a role in a signaling cascade by enhancing the kinase activity of SRC. Contributes to
    SRC-regulated transcription activation

         Gene Ontology (GO): 5 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005515protein binding ----
    GO:0005543phospholipid binding IEA--
    GO:0017124SH3 domain binding IPI17412687
    GO:0030296protein tyrosine kinase activator activity IDA17412687
    GO:0042169SH2 domain binding IPI17412687
         
    AFAP1L2 for ontologies           About GeneDecksing


    Phenotypes:
         4 GenomeRNAi human phenotypes for AFAP1L2:
     Decreased melanin production  Increased S DNA content  Increased cell number in G1, s  Increased gamma-H2AX phosphory 

    Animal Models:
       inGenious Targeting Laboratory - Custom generated mouse model solutions for AFAP1L2 
       inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for AFAP1L2

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for AFAP1L2 
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for AFAP1L2 

    miRNA
    Products:
        
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat AFAP1L2
    8/20 QIAGEN miScript miRNA Assays for microRNAs that regulate AFAP1L2 (see all 20):
    hsa-miR-30c hsa-miR-3607-3p hsa-miR-30d hsa-miR-219-5p hsa-miR-373* hsa-miR-374c hsa-miR-30a hsa-miR-924
    SwitchGear 3'UTR luciferase reporter plasmidAFAP1L2 3' UTR sequence
    Inhib. RNA
    Products:
        
    Browse for Gene Knock-down Tools from EMD Millipore
    OriGene RNAi products in human, mouse, rat for AFAP1L2
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat AFAP1L2

    Gene Editing
    Products:
    DNA2.0 Custom Protein Engineering Service for AFAP1L2
    Sirion Biotech Customized adenovirus for overexpression of AFAP1L2

    Clone
    Products:
         
    Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
    OriGene clones in human, mouse for AFAP1L2 (see all 14)
    OriGene ORF clones in mouse, rat for AFAP1L2
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector (see all 2): AFAP1L2 (NM_032550)
    Browse Sino Biological Human cDNA Clones
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for AFAP1L2
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat AFAP1L2
    Sirion Biotech Customized lentivirus for stable overexpression of AFAP1L2 
                         Customized lentivirus expression plasmids for stable overexpression of AFAP1L2 

    Cell Line
    Products:
         
    GenScript Custom overexpressing Cell Line Services for AFAP1L2
    Search LifeMap BioReagents cell lines for AFAP1L2
    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for AFAP1L2


    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section

    SuperPaths for AFAP1L2 About                                                                                                See pathways by source

    SuperPathContained pathways About
    1Cytoskeletal Signaling
    Cytoskeletal Signaling

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways


    1 Cell Signaling Technology (CST) Pathway for AFAP1L2
        Cytoskeletal Signaling



    AFAP1L2 for pathways           About GeneDecksing

    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for AFAP1L2

    STRING Interaction Network Preview (showing 5 interactants - click image to see 7)

    5/8 Interacting proteins for AFAP1L2 (Q8N4X52, 3 ENSP000003030424) via UniProtKB, MINT, STRING, and/or I2D (see all 8)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    RASA1P209363, ENSP000002743764I2D: score=1 STRING: ENSP00000274376
    SRCP129313, ENSP000003509414I2D: score=1 STRING: ENSP00000350941
    ACDENSP000003774964STRING: ENSP00000377496
    POT1ENSP000003502494STRING: ENSP00000350249
    TERF1ENSP000002766034STRING: ENSP00000276603
    About this table

    Gene Ontology (GO): 5/7 biological process terms (GO ID links to tree view) (see all 7):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006954inflammatory response IDA17412687
    GO:0007346regulation of mitotic cell cycle IDA17412687
    GO:0032675regulation of interleukin-6 production IDA17412687
    GO:0032757positive regulation of interleukin-8 production IDA17412687
    GO:0045742positive regulation of epidermal growth factor receptor signaling pathway IDA17412687

    AFAP1L2 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for AFAP1L2 (AF1L2)

    Search CenterWatch for drugs/clinical trials and news about AFAP1L2 / AF1L2

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for AFAP1L2 gene (2 alternative transcripts): 
    NM_001001936.1  NM_032550.2  

    Unigene Cluster for AFAP1L2:

    Actin filament associated protein 1-like 2
    Hs.501106  [show with all ESTs]
    Unigene Representative Sequence: NM_001001936
    7 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000304129(uc001lbm.3 uc010qsd.2) ENST00000369271(uc001lbn.3 uc001lbo.3 uc010qse.2 uc001lbp.3 uc001lbr.1)
    ENST00000491814(uc001lbq.1) ENST00000486300 ENST00000419268 ENST00000483496
    ENST00000545353

    miRNA
    Products:
         
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat AFAP1L2
    8/20 QIAGEN miScript miRNA Assays for microRNAs that regulate AFAP1L2 (see all 20):
    hsa-miR-30c hsa-miR-3607-3p hsa-miR-30d hsa-miR-219-5p hsa-miR-373* hsa-miR-374c hsa-miR-30a hsa-miR-924
    SwitchGear 3'UTR luciferase reporter plasmidAFAP1L2 3' UTR sequence
    Inhib. RNA
    Products:
         
    Browse for Gene Knock-down Tools from EMD Millipore
    OriGene RNAi products in human, mouse, rat for AFAP1L2
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat AFAP1L2
    Clone
    Products:
         
    OriGene clones in human, mouse for AFAP1L2 (see all 14)
    OriGene ORF clones in mouse, rat for AFAP1L2
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector (see all 2): AFAP1L2 (NM_032550)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for AFAP1L2
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat AFAP1L2
    Sirion Biotech Customized lentivirus for stable overexpression of AFAP1L2 
                         Customized lentivirus expression plasmids for stable overexpression of AFAP1L2 
    Primer
    Products:
        
    OriGene qPCR primer pairs and template standards for AFAP1L2
    OriGene qSTAR qPCR primer pairs in human, mouse for AFAP1L2
    SABiosciences RT2 qPCR Primer Assay in human, mouse, rat AFAP1L2
      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat AFAP1L2
      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat AFAP1L2

    Additional mRNA sequence: 

    AB067501.1 AF474151.1 AK123108.1 AK291712.1 AK294969.1 AK295538.1 BC016403.1 BC024314.1 
    BC033212.1 BC035713.1 

    12 DOTS entries:

    DT.444461  DT.101981461  DT.100786979  DT.102828116  DT.210446  DT.95160952  DT.99968703  DT.100698484 
    DT.121270727  DT.97842381  DT.100753165  DT.100836972 

    24/93 AceView cDNA sequences (see all 93):

    CR595409 AB067501 Z38874 AA404497 BP342007 BX280240 AI420374 AA570115 
    BE645538 AI420121 BC016403 AK123108 BC033212 AW006448 NM_032550 BM561567 
    CD515315 NM_001001936 AI658698 CK300428 BM918355 F01902 AI493714 CO245655 

    GeneLoc Exon Structure

    5/11 Alternative Splicing Database (ASD) splice patterns (SP) for AFAP1L2 (see all 11)    About this scheme

    ExUns: 1a · 1b ^ 2 ^ 3 ^ 4 ^ 5a · 5b ^ 6a · 6b ^ 7 ^ 8 ^ 9a · 9b · 9c ^ 10a · 10b ^ 11 ^ 12 ^ 13 ^ 14a · 14b ^ 15 ^ 16a · 16b ^ 17a · 17b ^
    SP1:              -     -           -                             -                                                     -                 -                     
    SP2:              -     -           -                             -                                                     -                 -                     
    SP3:                                -                                                                                   -                 -                     
    SP4:              -     -           -                             -                                                     -                 -                     
    SP5:                    -           -                             -                                                                                             

    ExUns: 18 ^ 19a · 19b ^ 20a · 20b ^ 21 ^ 22a · 22b · 22c
    SP1:                          -                           
    SP2:                                                      
    SP3:                          -                           
    SP4:                                                      
    SP5:                                                      


    ECgene alternative splicing isoforms for AFAP1L2

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    AFAP1L2 expression in normal human tissues (normalized intensities)      AFAP1L2 embryonic expression: see
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: AGTTTTGAGA
    AFAP1L2 Expression
    About this image


    AFAP1L2 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database 
     5/5 selected tissues (see all 5) fully expand
     
     Brain (Nervous System)    fully expand to see all 3 entries
             Oligodendrocyte Precursor Cells Forebrain White Matter
             brain/forebrain/telencephalon   
     
     Uncategorized (Uncategorized)    fully expand to see all 2 entries
             PureStem Progenitor EN7
     
     Intestine
             Human Villous Capillary Endothelial Cells (HVCEC)   
     
     Endothelium (Gastrointestinal Tract)
             Human Villous Capillary Endothelial Cells (HVCEC)   
     
     Placenta (Extraembryonic Tissues)

    See AFAP1L2 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for AFAP1L2

    SOURCE GeneReport for Unigene cluster: Hs.501106

    UniProtKB/Swiss-Prot: AF1L2_HUMAN, Q8N4X5
    Tissue specificity: Detected in spleen and thyroid, and at lower levels in kidney, brain, lung and pancreas

        SABiosciences Custom PCR Arrays for AFAP1L2
    Primer
    Products:
    OriGene qPCR primer pairs and template standards for AFAP1L2
    OriGene qSTAR qPCR primer pairs in human, mouse for AFAP1L2
    SABiosciences RT2 qPCR Primer Assay in human, mouse, rat AFAP1L2
    QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat AFAP1L2
    QIAGEN QuantiFast Probe-based Assays in human, mouse, rat AFAP1L2
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for AFAP1L2

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of chordates.

    Orthologs for AFAP1L2 gene from 5/11 species (see all 11)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Afap1l21 , 5 actin filament associated protein 1-like 21, 5 84.19(n)1
    83.5(a)1
      19 (52.04 cM)5
    2262501  NM_001177797.11  NP_001171268.11 
     569123615 
    chicken
    (Gallus gallus)
    Aves AFAP1L21 actin filament associated protein 1-like 2 71.74(n)
    73.78(a)
      423908  XM_421770.3  XP_421770.3 
    lizard
    (Anolis carolinensis)
    Reptilia AFAP1L26
    Uncharacterized protein
    67(a)
    1 ↔ 1
    GL344115.1(1056-62995)
    African clawed frog
    (Xenopus laevis)
    Amphibia BC057722.12   -- 80.17(n)    BC057722.1 
    zebrafish
    (Danio rerio)
    Actinopterygii LOC5673691 actin filament-associated protein 1-like 2-like 59.66(n)
    55.44(a)
      567369  XM_690662.4  XP_695754.3 


    ENSEMBL Gene Tree for AFAP1L2 (if available)
    TreeFam Gene Tree for AFAP1L2 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for AFAP1L2 gene
    AFAP12  AFAP1L12  
    1 SIMAP similar gene for AFAP1L2 using alignment to 3 protein entries:     AF1L2_HUMAN (see all proteins):
    AFAP1

    AFAP1L2 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/2568 SNPs in AFAP1L2 are shown (see all 2568)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 10 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs669762571,2
    C--109699006(+) GCAGA-/GT/GTGTG
    TGTGTGTGTGT
    GTGTG
    2 -- int11NA 2
    rs106272311,2
    C--116054775(+) GTGtt-/A/AA  
            
    aaaaa
    4 -- ut31 trp30--------
    rs1915853091,2
    --116054854(+) GAGGGC/TGATCA 2 -- ut310--------
    rs1843741171,2
    --116054858(+) GCGATA/CACCCT 2 -- ut310--------
    rs1492924951,2
    --116054897(+) AGGAGA/GATGAA 2 -- ut310--------
    rs283721301,2
    C--116054954(+) TTCCCT/CTAAAA 2 -- ut31 ese3 trp31Minor allele frequency- C:0.00NA 2
    rs1896583631,2
    --116055064(+) TGACAA/GGATTT 2 -- ut310--------
    rs1447524301,2
    C--116055069(+) GGATTG/TTAAGC 2 -- ut310--------
    rs1479014151,2
    C--116055237(+) TCATA-/GATGGT
    TTTACAGAT
    GATGG
    2 -- cds10--------
    rs1125358681,2
    C--116055282(+) TGTTT-/AAAAAT 2 -- ut311Minor allele frequency- A:0.50CSA 2

    HapMap Linkage Disequilibrium report for AFAP1L2 (116054583 - 116164515 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 4 variations for AFAP1L2:    About this table     
    Variant IDTypeSubtypePubMed ID
    esv2741173CNV Deletion23290073
    esv2741162CNV Deletion23290073
    dgv826n71CNV Loss21882294
    nsv7211OTHER Inversion18451855

    SABiosciences Cancer Mutation PCR Assays
    SeqTarget long-range PCR primers for resequencing AFAP1L2
    DNA2.0 Custom Variant and Variant Library Synthesis for AFAP1L2

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    OMIM gene information: 612420    OMIM disorders: --

    6 diseases for AFAP1L2:    About MalaCards
    noma    thyroid cancer    thyroiditis    alzheimer's disease
    colorectal cancer    gastric cancer


    AFAP1L2 for disorders           About GeneDecksing


    Congresses - knowledge worth sharing:  
    Alzheimer's & Parkinson's Diseases Congress (ADPD) 18 - 22 March 2015
    Genetic Association Database (GAD): AFAP1L2
    Human Genome Epidemiology (HuGE) Navigator: AFAP1L2 (2 documents)

    Export disorders for AFAP1L2 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for AFAP1L2 gene, integrated from 9 sources (see all 23):
    (articles sorted by number of sources associating them with AFAP1L2)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. XB130, a novel adaptor protein for signal transduction. (PubMed id 17412687)1, 2, 3 Xu J....Liu M. (2007)
    2. Prediction of the coding sequences of unidentified human genes. XXI. The complete sequences of 60 new cDNA clones from brain which code for large proteins. (PubMed id 11572484)1, 2, 3 Nagase T....Ohara O. (2001)
    3. Common genetic variation and performance on standardi zed cognitive tests. (PubMed id 20125193)1, 4 Cirulli E.T....Goldstein D.B. (2010)
    4. Human Variation in Alcohol Response Is Influenced by Variation in Neuronal Signaling Genes. (PubMed id 20201926)1, 4 Joslyn G....White R.L. (2010)
    5. A scan of chromosome 10 identifies a novel locus showing strong association with late-onset Alzheimer disease. (PubMed id 16385451)1, 4 Grupe A....Goate A. (2006)
    6. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    7. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (2004)
    8. The DNA sequence and comparative analysis of human chromosome 10. (PubMed id 15164054)1, 2 Deloukas P.... Rogers J. (2004)
    9. XB130, a new adaptor protein, regulates expression of tumor suppressive microRNAs in cancer cells. (PubMed id 23527086)1 Takeshita H....Liu M. (2013)
    10. Silencing of XB130 is associated with both the prognos is and chemosensitivity of gastric cancer. (PubMed id 22927913)1 Shi M....Liao W. (2012)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 84632 HGNC: 25901 AceView: KIAA1914 Ensembl:ENSG00000169129 euGenes: HUgn84632
    ECgene: AFAP1L2 H-InvDB: AFAP1L2

    (According to HUGE)
    About This Section
    HUGE: KIAA1914

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for AFAP1L2 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for AFAP1L2 gene:
    Search GeneIP for patents involving AFAP1L2

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0 and Sirion Biotech, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Sirion Biotech, Cell lines from GenScript, and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
    About This Section

     EMD Millipore Mono- and Polyclonal Antibodies for the study of AFAP1L2
     Browse Purified and Recombinant Proteins at EMD Millipore
     Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
     Browse for Gene Knock-down Tools from EMD Millipore
     Browse Small Molecules at EMD Millipore
     Browse Kits and Assays available from EMD Millipore
     
     EMD Millipore Custom Antibody & Bulk Services
     EMD Millipore Preclinical / Clinical Development Services
     EMD Millipore Immunoassay Services
     EMD Millipore Target Screening & Profiling Services

      
     Browse Antibodies   Browse Cell Culture Products  
     Browse ELISAs   Browse Flow Cytometry Kits  
     Browse Primer Pairs   Browse Kinase Activity Assays/Reagents  
     Browse ELISpot Kits/Development Modules   Browse TFB/Immunoprecipitation Assays  
     Browse Apoptosis Detection Kits/Reagents   Browse Ubiquitin Proteasome Pathway (UPP) Assay Kits/Reagents  
     Browse DNA Damage/Repair Kits/Reagents   Browse Multiplex/Array Assay Kits/Reagents  
     Browse Cell Selection/Detection Kits/Reagents   Browse Secondary Antibodies/Controls/Staining Reagents  
     Browse Protease Activity Assays and Reagents   Browse Recombinant/Natural Proteins  
     Browse Stem Cell Products   Browse Tocris Biochemicals & Compounds  
     Browse cDNA Clones   Browse Proteome Profiler Antibody Arrays  
     OriGene Antibodies for AFAP1L2   OriGene RNAi products in human, mouse, rat for AFAP1L2  
     OriGene qPCR primer pairs and template standards for AFAP1L2   OriGene Protein Over-expression Lysate for AFAP1L2  
     OriGene MassSpec something-or-other for AFAP1L2   OriGene clones in human, mouse for AFAP1L2  
     OriGene qSTAR qPCR primer pairs in human, mouse for AFAP1L2   OriGene Purified Protein for AFAP1L2  
     OriGene ORF clones in mouse, rat for AFAP1L2   OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling  
     OriGene Custom Antibody Services for AFAP1L2   OriGene Custom Protein Services for AFAP1L2  

     
     
     QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat AFAP1L2
     QIAGEN SeqTarget long-range PCR primers for resequencing AFAP1L2
     QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat AFAP1L2
     QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat AFAP1L2
     QIAGEN QuantiFast Probe-based Assays in human, mouse, rat AFAP1L2
     QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat AFAP1L2
     GenScript Custom Purified and Recombinant Proteins Services for AFAP1L2 GenScript cDNA clones with any tag delivered in your preferred vector for AFAP1L2
     GenScript Custom Assay Services for AFAP1L2 GenScript Custom Superior Antibodies Services for AFAP1L2
     GenScript Custom overexpressing Cell Line Services for AFAP1L2 CloneReady with Over 120,000 Genes
     Gene Synthesis: Any Gene in Any Vector Vector-based siRNA and miRNA, Ready for Transfection
     Gene Mutant Library, Variants up to 10^11 Plasmid Preparation
     Custom Peptide Services
     Antibodies & Assays for AFAP1L2 

     Search Regulatory tfbs for AFAP1L2
     Search Chromatin IP Primers for AFAP1L2
     RT2 qPCR Primer Assay in human, mouse, rat AFAP1L2
     Search GNC Networks for AFAP1L2
     SABiosciences Custom PCR Arrays for AFAP1L2
     Search Tocris compounds for AFAP1L2 (AF1L2)
     Browse Sino Biological Proteins and Antibodies
     Browse Sino Biological Cell Lysates
     Browse Sino Biological cDNA Clones
     4000+ Proteins
     Search Sino Biological for antibodies, proteins & pathways
     Protein Production Services
     Transfection Reagents
     Protein A/G/L resins
     Isotyping reagents
     Search www.enzolifesciences.com for proteins, assays, substrates, inhibitors & antibodies
     Novus Tissue Slides
     AFAP1L2 antibodies
     AFAP1L2 proteins
     AFAP1L2 lysates
     Antibodies for AFAP1L2
     See all of Abcam's Antibodies, Kits and Proteins for AFAP1L2
     Custom Antibody / Protein Production Service
     Bulk Purchasing
     Advantages of Rabbit Monoclonal antibodies
     Abcam protocols and scientific support
     Browse ProSpec Recombinant Proteins




     Proteins for AFAP1L2
     Antibodies for AFAP1L2
     ELISAs for AFAP1L2
     CLIAs for AFAP1L2
     Search LifeMap BioReagents cell lines for AFAP1L2
     Gene Synthesis
     Protein Engineering
     Variant Library Synthesis
     Codon Optimization
     Protein Production and Purification
     Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for AFAP1L2
     SwitchGear 3'UTR luciferase reporter plasmids for AFAP1L2
     SwitchGear Promoter luciferase reporter plasmids for AFAP1L2
     ThermoFisher Antibodies for AFAP1L2
     Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat AFAP1L2
     inGenious Targeting Laboratory - Custom generated mouse model solutions for AFAP1L2
     inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for AFAP1L2
    Customized:
     lentivirus for stable overexpression of AFAP1L2
     lentivirus expression plasmids for stable overexpression of AFAP1L2
     adenovirus for overexpression of AFAP1L2
     LSBio Antibodies in human, mouse, rat for AFAP1L2
    Customized transgenic rodents for:
     Humanization
     Biomarker expression
     Off-target effect monitoring
     Translational medicine
     Tissue-specific gene expresssion
     Time-controlled gene expresssion
           
    GeneCards Homepage - Last full update: 23 Oct 2013 - Incrementals: 4 Nov 2013 , 7 Nov 2013 , 23 Jan 2014

    View Random Gene

    Category
    (GIFtS: 73)
    transforming growth factor, beta 1
    GIFtS Group
    The GeneCards human gene database gene index: 1 3 5 6 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z 


    Developed at the Crown Human Genome Center, Department of Molecular Genetics, the Weizmann Institute of Science

    Hot genes      Disease genes      AFAP1L2 gene at Home site.
    hostname: 356977-web1.xennexinc.com index build: 106 solr: 1.4