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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

AFAP1 Gene

protein-coding   GIFtS: 55
GCID: GC04M007682

Actin Filament Associated Protein 1

  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
Actin Filament Associated Protein 11 2     AFAP1102
110 KDa Actin Filament-Associated Protein2 3     Actin Filament-Associated Protein 12
AFAP2 3     Actin Filament-Associated Protein, 110 KDa2
AFAP-1102 3     

External Ids:    HGNC: 240171   Entrez Gene: 603122   Ensembl: ENSG000001965267   OMIM: 6082525   UniProtKB: Q8N5563   

Export aliases for AFAP1 gene to outside databases

Previous GC identifer: GC04M007811


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for AFAP1 Gene:
The protein encoded by this gene is a Src binding partner. It may represent a potential modulator of actin
filament integrity in response to cellular signals, and may function as an adaptor protein by linking Src family
members and/or other signaling proteins to actin filaments. Multiple transcript variants encoding different
isoforms have been found for this gene. (provided by RefSeq, Aug 2008)

GeneCards Summary for AFAP1 Gene: 
AFAP1 (actin filament associated protein 1) is a protein-coding gene. Diseases associated with AFAP1 include familial adenomatous polyposis, and prostate adenocarcinoma, and among its related super-pathways are IFN-gamma pathway. GO annotations related to this gene include actin binding and phospholipid binding. An important paralog of this gene is AFAP1L2.

UniProtKB/Swiss-Prot: AFAP1_HUMAN, Q8N556
Function: Can cross-link actin filaments into both network and bundle structures (By similarity). May modulate
changes in actin filament integrity and induce lamellipodia formation. May function as an adapter molecule that
links other proteins, such as SRC and PKC to the actin cytoskeleton. Seems to play a role in the development and
progression of prostate adenocarcinoma by regulating cell-matrix adhesions and migration in the cancer cells

Gene Wiki entry for AFAP1 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000004.11  NT_006051.18  NC_018915.2  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the AFAP1 gene promoter:
         Sox5   Sp1   Pax-6   MEF-2A   CREB   SRY   deltaCREB   Sox9   aMEF-2   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidAFAP1 promoter sequence
   Search SABiosciences Chromatin IP Primers for AFAP1

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat AFAP1


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 4p16   Ensembl cytogenetic band:  4p16.1   HGNC cytogenetic band: 4p16

AFAP1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
AFAP1 gene location

GeneLoc information about chromosome 4         GeneLoc Exon Structure

GeneLoc location for GC04M007682:  view genomic region     (about GC identifiers)

Start:
7,760,440 bp from pter      End:
7,941,653 bp from pter
Size:
181,214 bases      Orientation:
minus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: AFAP1_HUMAN, Q8N556 (See protein sequence)
Recommended Name: Actin filament-associated protein 1  
Size: 730 amino acids; 80725 Da
Subunit: Monomer and homomultimer. Interacts via its C-terminus with F-actin; probably involving AFAP1 multimers
(By similarity). Interacts with activated SRC SH3-SH2 domains. Interacts via its PH 1 domain with PRKCA, PRKCB
and PRKCI (By similarity)
Subcellular location: Cytoplasm, cytoskeleton. Note=Localizes with stress fibers in quiescent cells, concentrated
in cell motility structures such as lamellipodia, filopodia and membrane ruffles upon their induction
Miscellaneous: Knockdown in MDA-MB-231 cells resulted in loss of actin stress fibers, decreased adhesion and
spreading on fibronectin
Secondary accessions: A8K442 B4DMU2 E9PDT7 Q59EY5 Q9HBY1
Alternative splicing: 2 isoforms:  Q8N556-1   Q8N556-2   (No experimental confirmation available. Ref.2 (BAG60004) sequence is in conflict in position: 561:A->V)

Explore the universe of human proteins at neXtProt for AFAP1: NX_Q8N556

Explore proteomics data for AFAP1 at MOPED 

Post-translational modifications:

  • UniProtKB: Phosphorylated on tyrosine residues by SRC
  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_Q8N556

  • AFAP1 Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    AFAP1 Protein Expression
    REFSEQ proteins (2 alternative transcripts): 
    NP_001128119.1  NP_940997.1  

    ENSEMBL proteins: 
     ENSP00000353402   ENSP00000371983   ENSP00000410689   ENSP00000351245  

    Human Recombinant Protein Products for AFAP1: 
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    Cloud-Clone Corp. Proteins for AFAP1 

    Gene Ontology (GO): 3 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005737cytoplasm IDA--
    GO:0005925focal adhesion IDA--
    GO:0015629actin cytoskeleton IDA--

    AFAP1 for ontologies           About GeneDecksing



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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    HGNC Gene Families: 
    PLEKH: Pleckstrin homology (PH) domain containing

    2 InterPro protein domains:
     IPR001849 Pleckstrin_homology
     IPR011993 PH_like_dom

    Graphical View of Domain Structure for InterPro Entry Q8N556

    ProtoNet protein and cluster: Q8N556

    1 Blocks protein domain: IPB001849 Pleckstrin-like

    UniProtKB/Swiss-Prot: AFAP1_HUMAN, Q8N556
    Similarity: Contains 2 PH domains


    AFAP1 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: AFAP1_HUMAN, Q8N556
    Function: Can cross-link actin filaments into both network and bundle structures (By similarity). May modulate
    changes in actin filament integrity and induce lamellipodia formation. May function as an adapter molecule that
    links other proteins, such as SRC and PKC to the actin cytoskeleton. Seems to play a role in the development and
    progression of prostate adenocarcinoma by regulating cell-matrix adhesions and migration in the cancer cells

         Gene Ontology (GO): 3 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003779actin binding IEA--
    GO:0005515protein binding ----
    GO:0005543phospholipid binding IEA--
         
    AFAP1 for ontologies           About GeneDecksing


    Phenotypes:
         1 GenomeRNAi human phenotype for AFAP1:
     High actin ratio cells 

    Animal Models:
       inGenious Targeting Laboratory - Custom generated mouse model solutions for AFAP1 
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    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section

    SuperPaths for AFAP1 About                                                                                                See pathways by source

    SuperPathContained pathways About
    1Immune response IFN gamma signaling pathway
    Immune response IFN gamma signaling pathway0.43

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    1 EMD Millipore Pathway for AFAP1
        Immune response IFN gamma signaling pathway


    1 GeneGo (Thomson Reuters) Pathway for AFAP1
        Immune response IFN gamma signaling pathway



    AFAP1 for pathways           About GeneDecksing

    Interactions:

        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for AFAP1

    STRING Interaction Network Preview (showing 5 interactants - click image to see 10)

    5/10 Interacting proteins for AFAP1 (Q8N5563 ENSP000004106894) via UniProtKB, MINT, STRING, and/or I2D (see all 10)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    PRKCBP057713, ENSP000003053554I2D: score=3 STRING: ENSP00000305355
    PRKCDQ056553, ENSP000003316024I2D: score=3 STRING: ENSP00000331602
    PRKCGP051293, ENSP000002634314I2D: score=3 STRING: ENSP00000263431
    ACTC1P680323, ENSP000002903784I2D: score=2 STRING: ENSP00000290378
    PRKCZQ055133, ENSP000003678304I2D: score=2 STRING: ENSP00000367830
    About this table

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section

    AFAP1 for compounds           About GeneDecksing

    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for AFAP1

    2 Novoseek inferred chemical compound relationships for AFAP1 gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    leucine 41.6 4 11641786 (1), 14755689 (1), 10380016 (1), 11607843 (1)
    tyrosine 34 8 11641786 (2), 15314167 (2), 15485829 (1), 11607843 (1) (see all 5)

    Search CenterWatch for drugs/clinical trials and news about AFAP1

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
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    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for AFAP1 gene (3 alternative transcripts): 
    NM_001134647.1  NM_198595.2  NM_021638.4  

    Unigene Cluster for AFAP1:

    Actin filament associated protein 1
    Hs.529369  [show with all ESTs]
    Unigene Representative Sequence: NM_001134647
    8 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000360265 ENST00000505447 ENST00000513842 ENST00000382543 ENST00000508415
    ENST00000513856 ENST00000420658(uc011bwk.1) ENST00000358461(uc003gkg.1)

    miRNA
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    8/46 QIAGEN miScript miRNA Assays for microRNAs that regulate AFAP1 (see all 46):
    hsa-miR-513a-5p hsa-miR-128 hsa-miR-25 hsa-let-7a-2* hsa-miR-570 hsa-miR-4275 hsa-miR-183* hsa-miR-9
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    Additional mRNA sequence: 

    AB209676.1 AF188700.1 AK127962.1 AK290807.1 AK297631.1 BC015900.1 BC032777.1 D25248.1 
    XR_112616.1 

    6 DOTS entries:

    DT.97822158  DT.215914  DT.101956502  DT.121232595  DT.92067800  DT.100829322 

    24/126 AceView cDNA sequences (see all 126):

    AI085991 BF036843 NM_021638 BC032777 F02531 F06246 CB217097 R43661 
    AA292097 F08751 D57870 BU616014 AW151921 BU686680 AI913295 BX950996 
    BU164761 AI291099 CR606819 AI468446 AI188460 BQ182989 BU186955 NM_198595 

    GeneLoc Exon Structure

    5/12 Alternative Splicing Database (ASD) splice patterns (SP) for AFAP1 (see all 12)    About this scheme

    ExUns: 1a · 1b ^ 2a · 2b ^ 3a · 3b ^ 4 ^ 5 ^ 6a · 6b ^ 7 ^ 8a · 8b · 8c · 8d ^ 9a · 9b · 9c · 9d ^ 10 ^ 11 ^ 12 ^ 13 ^ 14 ^ 15 ^ 16 ^
    SP1:              -     -                       -                 -                       -                                                                     
    SP2:                                            -                 -                                                                                             
    SP3:                                                              -                       -                                                                     
    SP4:              -     -           -     -     -                 -                       -                                                                     
    SP5:                                                                                                                                                  -         

    ExUns: 17 ^ 18 ^ 19 ^ 20 ^ 21 ^ 22 ^ 23a · 23b
    SP1:                                                
    SP2:                                                
    SP3:                                                
    SP4:                                                
    SP5:                                                


    ECgene alternative splicing isoforms for AFAP1

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    AFAP1 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: GTGATACGTT
    AFAP1 Expression
    About this image


    See AFAP1 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for AFAP1

    SOURCE GeneReport for Unigene cluster: Hs.529369

    UniProtKB/Swiss-Prot: AFAP1_HUMAN, Q8N556
    Tissue specificity: Low expression in normal breast epithelial cell line MCF-10A and in tumorigenic breast cancer
    cell lines MCF-7, T-47D and ZR-75-1. Highly expressed in the invasive breast cancer cell lines MDA-MB-231 and
    MDA-MB-435. Overexpressed in prostate carcinoma

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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for AFAP1

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of chordates.

    Orthologs for AFAP1 gene from 4/10 species (see all 10)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Afap11 , 5 actin filament associated protein 11, 5 80.29(n)1
    85.87(a)1
      5 (19.02 cM)5
    702921  NM_027373.21  NP_081649.11 
     358933195 
    chicken
    (Gallus gallus)
    Aves AFAP11 actin filament associated protein 1 79.4(n)
    87.39(a)
      374034  NM_204205.1  NP_989536.1 
    lizard
    (Anolis carolinensis)
    Reptilia AFAP16
    Uncharacterized protein
    81(a)
    1 ↔ 1
    4(79727093-79800906)
    zebrafish
    (Danio rerio)
    Actinopterygii LOC5683561 actin filament-associated protein 1-like 68.21(n)
    71.05(a)
      568356  XM_691682.3  XP_696774.3 


    ENSEMBL Gene Tree for AFAP1 (if available)
    TreeFam Gene Tree for AFAP1 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for AFAP1 gene
    AFAP1L22  AFAP1L12  
    2 SIMAP similar genes for AFAP1 using alignment to 1 protein entry:     AFAP1_HUMAN:
    AFAP1L1    AFAP1L2

    AFAP1 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/4780 SNPs in AFAP1 are shown (see all 4780)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 4 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    VAR_0385794
    ----see VAR_0385792 V M mis40--------
    rs1512565971,2
    --7781310(+) ATCCAC/TGCCCA 2 -- int10--------
    rs1144307831,2
    C,F--7781317(+) CCCACG/ACTTTT 2 -- int11Minor allele frequency- A:0.03WA 118
    rs109378601,2
    C,F--7781329(+) TCCACG/CATACA 2 -- int18Minor allele frequency- C:0.13NA WA EA 504
    rs1404529221,2
    --7781358(+) CCTCAC/TTTTTT 2 -- int10--------
    rs100150311,2
    C--7781399(+) GGCTCT/CATCAA 2 -- int15Minor allele frequency- C:0.14NA WA EA 362
    rs1148654161,2
    C,F--7781403(+) CTATCA/GATCAT 2 -- int11Minor allele frequency- G:0.03WA 118
    rs1504746861,2
    --7781497(+) GTTCCG/TAAAAA 2 -- int10--------
    rs100251541,2
    C,F,H--7781560(+) AAAGTG/ACAAGG 2 -- int112Minor allele frequency- A:0.09NA NS EA WA 910
    rs1160014311,2
    F--7781659(+) CCTATT/CTCAAC 2 -- int11Minor allele frequency- C:0.02WA 118

    HapMap Linkage Disequilibrium report for AFAP1 (7760440 - 7941653 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 10/38 variations for AFAP1 (see all 38):    About this table     
    Variant IDTypeSubtypePubMed ID
    esv2727091CNV Deletion23290073
    esv2727096CNV Deletion23290073
    esv2727081CNV Deletion23290073
    esv2143898CNV Deletion18987734
    esv2727092CNV Deletion23290073
    esv2727089CNV Deletion23290073
    esv2144252CNV Deletion18987734
    esv2727079CNV Deletion23290073
    esv2727080CNV Deletion23290073
    nsv820965CNV Deletion20802225

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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    OMIM gene information: 608252    OMIM disorders: --

    7 diseases for AFAP1:    About MalaCards
    familial adenomatous polyposis    prostate adenocarcinoma    prostatitis    adenocarcinoma
    prostate cancer    endotheliitis    breast cancer


    AFAP1 for disorders           About GeneDecksing

    Genetic Association Database (GAD): AFAP1

    Export disorders for AFAP1 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for AFAP1 gene, integrated from 9 sources (see all 46):
    (articles sorted by number of sources associating them with AFAP1)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. AFAP-110 is required for actin stress fiber formation and cell adhesion in MDA-MB-231 breast cancer cells. (PubMed id 17520695)1, 2, 9 Dorfleutner A.... Flynn D.C. (2007)
    2. The intrinsic ability of AFAP-110 to alter actin filament integrity is linked with its ability to also activate cellular tyrosine kinases. (PubMed id 11641786)1, 3, 9 Baisden J.M....Flynn D.C. (2001)
    3. The actin filament-associated protein AFAP-110 is an adaptor protein that modulates changes in actin filament integrity. (PubMed id 11607843)1, 3, 9 Baisden J.M....Flynn D.C. (2001)
    4. Analysis of the role of the leucine zipper motif in regulating the ability of AFAP-110 to alter actin filament integrity. (PubMed id 14755689)1, 3, 9 Qian Y....Flynn D.C. (2004)
    5. AFAP-110 is overexpressed in prostate cancer and contributes to tumorigenic growth by regulating focal contacts. (PubMed id 17885682)2, 9 Zhang J.... Gallick G.E. (2007)
    6. Conversion of mechanical force into biochemical signaling. (PubMed id 15485829)2, 9 Han B....Liu M. (2004)
    7. Hypomethylation of Noncoding DNA Regions and Overexpre ssion of the Long Noncoding RNA, AFAP1-AS1, in Barrett's Esophagus and Esophagea l Adenocarcinoma. (PubMed id 23333711)1 Wu W....Meltzer S.J. (2013)
    8. System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation. (PubMed id 21406692)2 Rigbolt K.T....Blagoev B. (2011)
    9. Proteomic profiling of Myc-associated proteins. (PubMed id 21150319)1 Agrawal P....Sedivy J.M. (2010)
    10. Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis. (PubMed id 20068231)2 Olsen J.V....Mann M. (2010)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 60312 HGNC: 24017 AceView: AFAP Ensembl:ENSG00000196526 euGenes: HUgn60312
    ECgene: AFAP1 H-InvDB: AFAP1

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for AFAP1 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for AFAP1 gene:
    Search GeneIP for patents involving AFAP1

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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    GeneCards Homepage - Last full update: 23 Oct 2013 - Incrementals: 4 Nov 2013 , 7 Nov 2013 , 23 Jan 2014

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