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AFAP1 Gene

protein-coding GIFtS: 56

GC04M007811

actin filament associated protein 1
Symbol approved by the HUGO Gene Nomenclature Committee (HGNC) database

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc , and/or ⁷Ensembl, ⁸miRBase)
About This Section

Aliases
AFAP ^¹, ², ³
AFAP-110 ^¹, ², ³
FLJ56849 ^²
OTTHUMP00000155170 ^²

Descriptions
110 kDa actin filament-associated protein ^³
actin filament associated protein 1 ^²
actin filament-associated protein, 110 kDa ^²

External Ids
HGNC: 24017¹
Entrez Gene: 60312²
UniProtKB: Q8N556³
Ensembl: ENSG00000196526⁷

Search outside databases for aliases for AFAP1 gene

(According to Entrez Gene, Wikipedia's Gene Wiki,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

EntrezGene summary for AFAP1:

The protein encoded by this gene is a Src binding partner. It may represent a potential modulator

of actin filament integrity in response to cellular signals, and may function as an adaptor

protein by linking Src family members and/or other signaling proteins to actin filaments. Multiple

transcript variants encoding different isoforms have been found for this gene. [provided by

RefSeq]

UniProtKB/Swiss-Prot: AFAP1_HUMAN, Q8N556

Function: Can cross-link actin filaments into both network and bundle structures (By similarity).

May modulate changes in actin filament integrity and induce lamellipodia formation. May function

as an adapter molecule that links other proteins, such as SRC and PKC to the actin cytoskeleton.

Seems to play a role in the development and progression of prostate adenocarcinoma by regulating

cell-matrix adhesions and migration in the cancer cells

Gene Wiki entry for AFAP1

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 36),
and/or miRBase,
Genomic Views according to UCSC and Ensembl, Transcription factor binding sites according to SABiosciences)
About This Section

Genomic View:

UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 4p16 Ensembl cytogenetic band: 4p16.1 HGNC cytogenetic band: 4p16

AFAP1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)

GeneLoc gene densities for chromosome 4 GeneLoc Exon Structure

GeneLoc location for GC04M007811: (about GC identifiers)

Start:	7,811,340 bp from pter
End:	7,992,553 bp from pter
Size:	181,214 bases
Orientation:	minus strand

RefSeq DNA sequence:

NC_000004.10 NT_006051.17

(According to ¹UniProtKB, and/or Ensembl, Phosphorylation sites according to ²Phosphosite, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Enzo Life Sciences, Abnova, OriGene and/or, Abcam,
Biochemical Assays by Invitrogen, Millipore, R&D Systems, Cell Signaling Technology, and/or Enzo Life Sciences, Ontologies according to Gene Ontology Consortium 01 Apr 2009 and Entrez Gene, Antibodies by Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Cell Signaling Technology, Abcam, Abnova, and/or Novus Biologicals)
About This Section

UniProtKB/Swiss-Prot: AFAP1_HUMAN, Q8N556 (See protein sequence)

Recommended Name: Actin filament-associated protein 1

Size: 730 amino acids; 80725 Da

Subunit: Monomer and homomultimer. Interacts via its C-terminus with F-actin; probably involving

AFAP1 multimers (By similarity). Interacts with activated SRC SH3-SH2 domains. Interacts via its

PH 1 domain with PRKCA, PRKCB and PRKCI (By similarity)

Subcellular location: Cytoplasm, cytoskeleton. Note=Localizes with stress fibers in quiescent

cells, concentrated in cell motility structures such as lamellipodia, filopodia and membrane

ruffles upon their induction

Miscellaneous: Knockdown in MDA-MB-231 cells resulted in loss of actin stress fibers, decreased

adhesion and spreading on fibronectin

Secondary accessions: A8K442 Q59EY5 Q9HBY1

Post-translational modifications:

Phosphorylated on tyrosine residues by SRC¹

View phosphorylation sites using PhosphoSite²

REFSEQ proteins (3 alternative transcripts):

NP_001128119.1 NP_067651.2 NP_940997.1

ENSEMBL proteins:

ENSP00000353402 ENSP00000371983 ENSP00000351245

Human Recombinant Proteins

	Browse Drug Discovery Central at Invitrogen for human recombinant proteins
	Browse Purified and Recombinant Proteins at Millipore
	Browse Human Recombinant Proteins at Sigma-Aldrich
	Browse R&D Systems for human recombinant proteins
	Browse recombinant and purified proteins available from Enzo Life Sciences
	Recombinant Proteins from Abcam (AFAP)
	Human Recombinant Proteins from Abnova (AFAP)

OriGene Purified Recombinant Human Protein: AFAP1

2 Gene Ontology (GO) cellular component terms (links to tree view):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005737	cytoplasm	IEA	--
GO:0005856	cytoskeleton	IEA	--

About this table

Antibodies for AFAP1:

	Browse Antibodies Central at Invitrogen
	Browse Millipore's Extensive Line of Mono- and Polyclonal Antibodies
	Sigma-Aldrich Antibodies for AFAP1
	R&D Systems Antibodies for AFAP1 (AFAP)
	Antibodies from Abcam (AFAP), each with their Abpromise^SM
	Monoclonal and Polyclonal Antibodies from Abnova (AFAP)
	Novus Biologicals Antibodies for AFAP1

Assays for AFAP1:

	Browse Invitrogen for biochemical assays
	Browse Kits and Assays available from Millipore
	Browse R&D Systems for biochemical assays
	Browse biochemical assays available from Enzo Life Sciences

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

Graphical View of Domain Structure for InterPro Entry Q8N556

ProtoNet protein and cluster: Q8N556

1 Blocks protein family: IPB001849 Pleckstrin-like

UniProtKB/Swiss-Prot: AFAP1_HUMAN, Q8N556

Similarity: Contains 2 PH domains

(According to MGI Jun 06 2009, UniProtKB, IUBMB,and/or Genatlas,
shRNA from OriGene, Sigma-Aldrich, RNAi from Sigma-Aldrich,
RNAi Products, Clones, and Q-PCR Products from Invitrogen, Millipore, OriGene, and/or Abnova, siRNAs from Applied Biosystems, SYBR primers from OriGene, Cell-based Assays from Millipore, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
About This Section

Inhib. RNA:		Invitrogen RNAi Products for gene knock-down (AFAP1)
		Browse for Gene Knock-down Tools from Millipore
		Browse Abnova for Chimera RNAi Products

OriGene 29mer shRNA kit in GFP-retroviral vectors (see all 3): NM_001134647

Applied Biosystems Silencer® siRNAs for AFAP1

Sigma-Aldrich siRNA for AFAP1

Sigma-Aldrich shRNA Panels and shRNA for AFAP1

Explore Sigma-Aldrich super-pooled esiRNAs

Clones:		Invitrogen Clones for AFAP1
		Browse Clones for the Expression of Recombinant Proteins Available from Millipore

OriGene GFP tagged cDNA clones in CMV expression vector (see all 3): NM_001134647
Myc/DDK tagged cDNA clones in CMV expression vector (see all 3): NM_001134647
untagged cDNA clones in CMV expression vector (see all 3): NM_001134647

Primers:

Browse Quantitative PCR Central at Invitrogen for Q-PCR LUX™ Primers

OriGene genome-wide validated SYBR primer pairs: NM_001134647

UniProtKB/Swiss-Prot: AFAP1_HUMAN, Q8N556

Function: Can cross-link actin filaments into both network and bundle structures (By similarity).

May modulate changes in actin filament integrity and induce lamellipodia formation. May function

as an adapter molecule that links other proteins, such as SRC and PKC to the actin cytoskeleton.

Seems to play a role in the development and progression of prostate adenocarcinoma by regulating

cell-matrix adhesions and migration in the cancer cells

1 Gene Ontology (GO) molecular function term (links to tree view):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0003779	actin binding	IEA	--

About this table

(Pathways according to Invitrogen (maps by GeneGo), Millipore, Cell Signaling Technology, Sigma-Aldrich, KEGG and/or UniProtKB,
Sets of similar genes according to GeneDecks, Proteins Network according to SABiosciences, Interactions according to ¹UniProtKB, ²MINT, and/or ³STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
About This Section

Gene Network Central^TM Interacting Genes and Proteins Network for AFAP1

5/6 Interacting proteins for AFAP1 (ENSP00000353402³) via UniProtKB, MINT, and/or STRING (see all 6 )

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
SRC	ENSP00000362659³	STRING (score=.987)
GSTCD	ENSP00000353695³	STRING (score=.853)
ACTA1	ENSP00000355645³	STRING (score=.8)
ACTC1	ENSP00000290378³	STRING (score=.798)
PRKCA	ENSP00000284384³	STRING (score=.796)

About this table

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, Sigma-Aldrich, Tocris Bioscience, and/or Novoseek and Drugs according to Enzo Life Sciences and/or PharmGKB)
About This Section

Browse drugs & compounds from Enzo Life Sciences

Browse Small Molecules at Sigma-Aldrich

Browse Tocris compounds for AFAP1
2 Novoseek chemical compound relationships for AFAP1 gene

Compound	Score	Articles	PubMed IDs for Articles with Shared Sentences (# sentences)
leucine	42.74	4	11641786 (1), 14755689 (1), 10380016 (1), 11607843 (1)
tyrosine	35.41	8	11641786 (2), 15314167 (2), 15485829 (1), 11607843 (1) (see all 5)

About this table

(GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 219 Homo sapiens; Jun 2 2009) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView,
non coding RNAs according to RNAdb,
ESTs according to GeneTide,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from Invitrogen, Millipore, and/or Abnova,
siRNAs from Applied Biosystems, Sigma-Aldrich,
shRNA from Sigma-Aldrich, OriGene,
Tagged/untagged cDNA clones from OriGene,
Expression Assays from Applied Biosystems)
About This Section

Inhib. RNA:		Invitrogen RNAi Products for gene knock-down (AFAP1)
		Browse for Gene Knock-down Tools from Millipore
		Browse Abnova for Chimera RNAi Products

OriGene 29mer shRNA kit in GFP-retroviral vectors (see all 3): NM_001134647

Sigma-Aldrich siRNA for AFAP1

Sigma-Aldrich shRNA Panels and shRNA for AFAP1

Explore Sigma-Aldrich super-pooled esiRNAs

Applied Biosystems Silencer® siRNAs:

NM_001134647 NM_198595

REFSEQ mRNAs for AFAP1 gene (3 alternative transcripts):

NM_001134647.1 NM_021638.4 NM_198595.2

Applied Biosystems TaqMan ® Gene Expression Assays:

NM_001134647 NM_198595

               OriGene GFP tagged cDNA clones in CMV expression vector (see all 3): NM_001134647
                                 Myc/DDK tagged cDNA clones in CMV expression vector (see all 3): NM_001134647
                                 untagged cDNA clones in CMV expression vector (see all 3): NM_001134647

Additional cDNA sequence:

AB209676.1 AF188700.1 AK127962.1 AK290807.1 AK297631.1 BC015900.1 BC032777.1 CR606819.1

D25248.1

6 DOTS entries:

DT.97822158 DT.215914 DT.101956502 DT.100829322 DT.121232595 DT.92067800

24/126 AceView cDNA sequences (see all 126 ):

F02531 BC032777 BU686680 NM_021638 AI188460 AI468446 AI085991 BF036843

AI913295 BU164761 BX950996 D57870 AI291099 BQ182989 AW151921 CB217097

F06246 R43661 F08751 BU186955 BU616014 CR606819 AA322072 NM_198595

highest scoring ESTs for AFAP1:

AI878896 AL706148 AL708077 AU077262 BI561136 BM828817 BX646525 AA045547 AA045548 AA292096

Unigene Cluster for AFAP1:

Actin filament associated protein 1

Hs.529369 [show with all ESTs]

Unigene Representative Sequence: NM_001134647

GeneLoc Exon Structure

5/12 Alternative Splicing Database (ASD) splice patterns (SP) for AFAP1 (see all 12 )

ExUns:	1a	·	1b	^	2a	·	2b	^	3a	·	3b	^	4	^	5	^	6a	·	6b	^	7	^	8a	·	8b	·	8c	·	8d	^	9a	·	9b	·	9c	·	9d	^	10	^	11	^	12	^	13	^	14	^	15	^	16	^
SP1:					-		-								-						-								-
SP2:															-						-
SP3:																					-								-
SP4:					-		-				-		-		-						-								-
SP5:																																																	-

ExUns:	17	^	18	^	19	^	20	^	21	^	22	^	23a	·	23b
SP1:
SP2:
SP3:
SP4:
SP5:

About this scheme

ECgene alternative splicing isoforms for AFAP1

3 Ensembl transcripts including schematic representations:

ENST00000360265 ENST00000382543 ENST00000358461

(Experimental results according to ¹GeneNote and GNF BioGPS,
probe sets-to-genes annotations according to ²GeneAnnot , ³GeneTide , Sets of similar genes according to GeneDecks, Electronic Northern calculations according to data from UniGene (Build 219 Homo sapiens), SAGE tags according to CGAP, plus additional links to SOURCE, and/or GNF BioGPS, and/or EXPOLDB, and/or UniProtKB,
Expression Assays from Applied Biosystems )
About This Section

AFAP1 expression in normal and diseased human tissues

Applied Biosystems TaqMan ® Gene Expression Assays for AFAP1

¹ / ² / ³

3 probe-sets matching AFAP1 gene

Affymetrix probe-set	Array	# genes	Sensitivity	Specificity	Correlation	Length	Gb_Accession	Consensus	Uniqueness	Score	Rank
Affymetrix probe-set	Array	GeneAnnot data			GeneNote data		GeneTide data
37578_at²^{, 3}	U95-A	1	1.00	1.00	1.00	1.00	D25248	0.60	1.00	0.82	1
203563_at²^{, 3}	U133-A	1	1.00	1.00	--	--	NM_021638	0.60	1.00	0.82	1
203563_at²	U133Plus2	1	1.00	1.00	--	--	--	--	--	--	--

GeneDecks AFAP1 for binary patterns associated with the probe-sets selected above

About GeneDecksing

About this table

Data from

(Publications) and GNF BioGPS
About these images
About these images

CGAP SAGE TAG: GTGATACGTT

SOURCE GeneReport for Unigene cluster: Hs.529369
UniProtKB/Swiss-Prot: AFAP1_HUMAN, Q8N556
Tissue specificity: Low expression in normal breast epithelial cell line MCF-10A and in tumorigenic
breast cancer cell lines MCF-7, T-47D, and ZR75-1. Highly expressed in the invasive breast cancer
cell lines MDA-MB-231 and MDA-MB-435

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD and/or ⁵MGI Jun 06 2009, with possible further links to Flybase and/or WormBase, Gene Trees according to Ensembl)
About This Section

Orthologs for AFAP1 gene from 5/7 species (see all 7 )

Organism	Gene	Locus	Description	Human Similarity	NCBI accessions
dog (Canis familiaris)	AFAP1¹	--	actin filament associated protein 1	84.17(n) 90.75(a)	488786 XM_545904.2 XP_545904.2
chimpanzee (Pan troglodytes)	AFAP1¹	--	actin filament associated protein 1	99.36(n) 99.73(a)	461111 XM_517101.2 XP_517101.2
cow (Bos taurus)	AFAP1¹	--	actin filament associated protein 1	84.95(n) 91.55(a)	534032 XM_613646.3 XP_613646.3
rat (Rattus norvegicus)	Afap1¹	--	actin filament associated protein 1	84(n) 90.95(a)	140935 NM_080900.1 NP_543176.1
mouse (Mus musculus)	Afap1^{1, 5}	5⁵	actin filament associated protein 1^{1, 5}	84.59(n)¹ 92.04(a)¹	70292¹ NM_027373.2¹ NP_081649.1¹ AI848729⁵ AK011153⁵ (see all 15)

About this table Species with no ortholog for AFAP1

ENSEMBL Gene Tree for AFAP1

(Paralogs according to ¹HomoloGene
and ²Ensembl, Pseudogenes according to ³Pseudogene.org)
About This Section

Paralogs for AFAP1 gene

AFAP1L2² AFAP1L1²

(According to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, and UniProtKB, Linkage Disequilibrium by HapMap, Genotyping Reagents from Applied Biosystems)
About This Section

10/1634 NCBI SNPs in AFAP1 are shown (see all 1634 )
(Click for Applied Biosystems TaqMan ® Genotyping Assay) (see all 482)

AB	SNP ID	Valid	Chr 4 pos	Sequence	Recs	AA Chg	Type	More	Recs	Pop	Total sample	More
AB	Genomic Data				Transcription Data				Allele Frequencies
				--	--	--		--	--			--
	rs2240054^1,2	A,C,F,H,O	7816093(-)	`CCAGAT/CAGGCC`	2	--	ut3¹		8	EA EU WA NA	2048
	rs2269850^1,2	A,C,F,H,O	7814661(-)	`TCTGCC/TGGGAA`	2	--	ut3¹ ese³		13	EA NA EU WA	2366
	rs2285770^1,2	A,C,F,H,O	7812111(-)	`CTGCCG/ATAAAT`	2	--	ut3¹ ese³		9	EA NA EU WA	2082
	rs2285771^1,2	A,C,F,H,O	7812014(-)	`GCACCC/TAGGAA`	2	--	ut3¹ ese³		12	EA NA EU WA	2382
	rs2285764^1,2	A,C,F,H,O	7814061(-)	`TGCCCG/AACGGC`	2	--	ut3¹ ese³		7	NA EU EA WA	562
	rs4689163^1,2	A,C,F,H	7813256(+)	`CCCTCA/GAATCT`	2	--	ut3¹ ese³		7	NA EU EA WA	560
	rs11737447^1,2	A,C,F,H	7810876(+)	`TGAGAG/ACCTAG`	1	--	ng5¹		4	EU EA WA	408
	rs2285763^1,2	C,F,H,O	7814204(-)	`GTCACG/AGTCCT`	2	--	ut3¹ ese³		7	NA EU EA WA	516
	rs2240056^1,2	A,C,F,H	7813213(-)	`TGGGCC/GATGGC`	2	--	ut3¹		4	EU EA WA	410
	rs2285762^1,2	C,F,H,O	7814305(-)	`TTGACG/ACTCTT`	2	--	ut3¹ ese³		8	EA EU WA NA	1862

About this table

HapMap Linkage Disequilibrium images for AFAP1 (up to first 250kb)

(in which this Gene is Involved, According to OMIM, UniProtKB, PharmGKB, Genatlas, GeneTests, Blood group antigen gene mutations by BGMUT, HGMD, GAD, HuGE Navigator, BCGD, and/or TGDB.)
About This Section

OMIM: 608252

UniProtKB/Swiss-Prot: AFAP1_HUMAN, Q8N556

Overexpressed in prostate carcinoma, expression levels positively correlate with

aggressiveness of the disease

(Possibly Related Articles in Doctor's Guide)
About This Section

(in PubMed. Associations of this gene to articles via ¹Novoseek, ²HGNC, ³Entrez Gene, ⁴UniProtKB/Swiss-Prot, ⁵UniProtKB/TrEMBL, ⁶GAD, and/or ⁷PharmGKB)
About This Section

10/40 PubMed articles for AFAP1 gene (see all 40 ):

AFAP-110 is required for actin stress fiber formation and cell adhesion in MDA-MB-231 breast cancer cells. (PubMed id 17520695)^{1, 3, 4} Dorfleutner A....Flynn D.C. (2007)
The intrinsic ability of AFAP-110 to alter actin filament integrity is linked with its ability to also activate cellular tyrosine kinases. (PubMed id 11641786)^{1, 2, 3} Baisden J.M....Flynn D.C. (2001)
The actin filament-associated protein AFAP-110 is an adaptor protein that modulates changes in actin filament integrity. (PubMed id 11607843)^{1, 2, 3} Baisden J.M....Flynn D.C. (2001)
Analysis of the role of the leucine zipper motif in regulating the ability of AFAP-110 to alter actin filament integrity. (PubMed id 14755689)^{1, 2, 3} Qian Y....Flynn D.C. (2004)
AFAP-110 is overexpressed in prostate cancer and contributes to tumorigenic growth by regulating focal contacts. (PubMed id 17885682)^{1, 4} Zhang J....Gallick G.E. (2007)
Conversion of mechanical force into biochemical signaling. (PubMed id 15485829)^{1, 4} Han B....Liu M. (2004)
Combining protein-based IMAC, peptide-based IMAC, and MudPIT for efficient phosphoproteomic analysis. (PubMed id 18220336)⁴ Cantin G.T....Yates J.R. III (2008)
A quantitative atlas of mitotic phosphorylation. (PubMed id 18669648)⁴ Dephoure N.... Gygi S.P. (2008)
Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. (PubMed id 16344560)³ Kimura K.... Sugano S. (2006)
Phosphoproteome analysis of the human mitotic spindle. (PubMed id 16565220)⁴ Nousiainen M.... Koerner R. (2006)

(in PubMed, OMIM, and NCBI Bookshelf)
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		AND	OR
Aliases
Free Text

Query String		PubMed OMIM NCBI Bookshelf
	(Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, and/or H-InvDB)
About This Section

Entrez Gene: 60312	HGNC: 24017	AceView: AFAP	Ensembl:ENSG00000196526	euGenes: HUgn60312
ECgene: AFAP1	H-InvDB: AFAP1

(According to HUGE)
About This Section

(According to ATLAS, HORDE, IMGT, MTDB, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section

Licensable Technologies for AFAP1
(Available from WIS Yeda, Salk, Tufts)

About This Section

(Reagents available from Applied Biosystems, Antibodies and assays by Cell Signaling Technology, Abcam, Novus Biologicals,
Sigma-Aldrich, R&D Systems, Millipore, Abnova, and/or Invitrogen, Clones available from OriGene,and/or Invitrogen, Drugs and/or compounds by Sigma-Aldrich,
Enzo Life Sciences, and/or Tocris Bioscience)
About This Section

Products for AFAP1:

TaqMan ® Gene Expression Assays

TaqMan ® Genotyping Assays

Free SNP selection tool

Invitrogen iPath Pathways	Invitrogen BLOCK-iT™ RNAi
Invitrogen Antibodies	Invitrogen Assays
Invitrogen Clones	Invitrogen Q-PCR Products
Invitrogen Human Recombinant Kinases	Invitrogen Custom Antibody and Peptide Service
Invitrogen Proteins / Assays / Screening Services	Search Invitrogen catalog for AFAP1-related products

	Millipore Custom Antibody & Bulk Services
	Millipore Preclinical / Clinical Development Services
	Millipore Immunoassay Services
	Millipore Target Screening & Profiling Services

	Predesigned and custom siRNAs for AFAP1		Antibodies for AFAP1
	Explore super-pooled esiRNAs		Browse proteins at Sigma-Aldrich
	Lentivirus-delivered shRNAs for AFAP1		Browse small molecules at Sigma-Aldrich
	"Your Favorite Gene" Pathways		feedback

	Antibodies		Primer Pairs
	Cell Culture Products		ELISAs
	Flow Cytometry Kits		Protease Activity Assays & Reagents
	Cell Selection/Detection Kits & Reagents		ELISA/Assay Development Kits & Reagents
	Multiplex/Array Assay Kits & Reagents		ELISpot Kits & Development Modules
	Recombinant & Natural Proteins

	Recombinant Proteins (AFAP)
	Antibodies (AFAP)
	Search for Chimera RNAi
	Custom Service for Mouse Mab
	Custom Service for Rabbit Pab from Full-length Protein

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	Recombinant Proteins (AFAP)
	Antibodies (AFAP)

	Tagged/untagged cDNA clones
	Validated SYBR primer pairs
	Purified proteins from HEK293T cells
	Western blot validated antibodies
	shRNA in GFP-retroviral vector

Search Tocris compounds for AFAP1

Search www.enzolifesicences.com for proteins, assays, substrates, inhibitors & antibodies

Antibodies for AFAP1

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AFAP1 Gene

protein-coding GIFtS: 56

Aliases &
Descriptions
for AFAP1

Summaries
for AFAP1

Genomic Location
for AFAP1

Proteins
for AFAP1

Protein Domains/
Families
for AFAP1

Gene Function
for AFAP1

Pathways & Interactions
for AFAP1

Drugs & Compounds
for AFAP1

Transcripts
for AFAP1

Expression
for AFAP1

Orthologs
for AFAP1

Paralogs
for AFAP1

SNPs/Variants
for AFAP1

Disorders & Mutations
for AFAP1

Medical News
for AFAP1

Publications
for AFAP1

Search for AFAP1

Genome Databases showing AFAP1

Other Databases showing AFAP1

Specialized Databases showing AFAP1

Licensable Technologies
for AFAP1

Services
for AFAP1

Gene Index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

AFAP1 Gene

protein-coding GIFtS: 56

Aliases & Descriptionsfor AFAP1

Summariesfor AFAP1

Genomic Locationfor AFAP1

Proteinsfor AFAP1

Protein Domains/Familiesfor AFAP1

Gene Functionfor AFAP1

Pathways & Interactionsfor AFAP1

Drugs & Compoundsfor AFAP1

Transcriptsfor AFAP1

Expression for AFAP1

Orthologsfor AFAP1

Paralogsfor AFAP1

SNPs/Variantsfor AFAP1

Disorders & Mutationsfor AFAP1

Medical Newsfor AFAP1

Publicationsfor AFAP1

Search for AFAP1

Genome Databases showing AFAP1

Other Databases showing AFAP1

Specialized Databases showing AFAP1

Licensable Technologiesfor AFAP1

Servicesfor AFAP1

Gene Index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

Aliases &
Descriptions
for AFAP1

Summaries
for AFAP1

Genomic Location
for AFAP1

Proteins
for AFAP1

Protein Domains/
Families
for AFAP1

Gene Function
for AFAP1

Pathways & Interactions
for AFAP1

Drugs & Compounds
for AFAP1

Transcripts
for AFAP1

Expression
for AFAP1

Orthologs
for AFAP1

Paralogs
for AFAP1

SNPs/Variants
for AFAP1

Disorders & Mutations
for AFAP1

Medical News
for AFAP1

Publications
for AFAP1

Licensable Technologies
for AFAP1

Services
for AFAP1