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Aliases for AFAP1 Gene

Aliases for AFAP1 Gene

  • Actin Filament Associated Protein 1 2 3
  • AFAP 3 4 6
  • 110 KDa Actin Filament-Associated Protein 3 4
  • AFAP-110 3 4
  • AFAP110 3 6
  • Actin Filament-Associated Protein, 110 KDa 3
  • Actin Filament-Associated Protein 1 3

External Ids for AFAP1 Gene

Summaries for AFAP1 Gene

Entrez Gene Summary for AFAP1 Gene

  • The protein encoded by this gene is a Src binding partner. It may represent a potential modulator of actin filament integrity in response to cellular signals, and may function as an adaptor protein by linking Src family members and/or other signaling proteins to actin filaments. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Aug 2008]

GeneCards Summary for AFAP1 Gene

AFAP1 (Actin Filament Associated Protein 1) is a Protein Coding gene. Among its related pathways are Immune response IFN gamma signaling pathway. GO annotations related to this gene include phospholipid binding and actin binding. An important paralog of this gene is AFAP1L2.

UniProtKB/Swiss-Prot for AFAP1 Gene

  • Can cross-link actin filaments into both network and bundle structures (By similarity). May modulate changes in actin filament integrity and induce lamellipodia formation. May function as an adapter molecule that links other proteins, such as SRC and PKC to the actin cytoskeleton. Seems to play a role in the development and progression of prostate adenocarcinoma by regulating cell-matrix adhesions and migration in the cancer cells.

Gene Wiki entry for AFAP1 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for AFAP1 Gene

Genomics for AFAP1 Gene

Genomic Location for AFAP1 Gene

Start:
7,758,713 bp from pter
End:
7,939,926 bp from pter
Size:
181,214 bases
Orientation:
Minus strand

Genomic View for AFAP1 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for AFAP1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for AFAP1 Gene

Regulatory Elements for AFAP1 Gene

Proteins for AFAP1 Gene

  • Protein details for AFAP1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8N556-AFAP1_HUMAN
    Recommended name:
    Actin filament-associated protein 1
    Protein Accession:
    Q8N556
    Secondary Accessions:
    • A8K442
    • B4DMU2
    • E9PDT7
    • Q59EY5
    • Q9HBY1

    Protein attributes for AFAP1 Gene

    Size:
    730 amino acids
    Molecular mass:
    80725 Da
    Quaternary structure:
    • Monomer and homomultimer. Interacts via its C-terminus with F-actin; probably involving AFAP1 multimers (By similarity). Interacts with activated SRC SH3-SH2 domains. Interacts via its PH 1 domain with PRKCA, PRKCB and PRKCI (By similarity).
    Miscellaneous:
    • Knockdown in MDA-MB-231 cells resulted in loss of actin stress fibers, decreased adhesion and spreading on fibronectin

    Alternative splice isoforms for AFAP1 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for AFAP1 Gene

Proteomics data for AFAP1 Gene at MOPED

Post-translational modifications for AFAP1 Gene

Other Protein References for AFAP1 Gene

No data available for DME Specific Peptides for AFAP1 Gene

Domains for AFAP1 Gene

Gene Families for AFAP1 Gene

HGNC:
  • PLEKH :Pleckstrin homology (PH) domain containing

Protein Domains for AFAP1 Gene

UniProtKB/Swiss-Prot:

AFAP1_HUMAN
Domain:
  • Contains 2 PH domains.:
    • Q8N556
genes like me logo Genes that share domains with AFAP1: view

Function for AFAP1 Gene

Molecular function for AFAP1 Gene

UniProtKB/Swiss-Prot Function: Can cross-link actin filaments into both network and bundle structures (By similarity). May modulate changes in actin filament integrity and induce lamellipodia formation. May function as an adapter molecule that links other proteins, such as SRC and PKC to the actin cytoskeleton. Seems to play a role in the development and progression of prostate adenocarcinoma by regulating cell-matrix adhesions and migration in the cancer cells.

Gene Ontology (GO) - Molecular Function for AFAP1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003779 actin binding IEA --
genes like me logo Genes that share ontologies with AFAP1: view

Phenotypes for AFAP1 Gene

GenomeRNAi human phenotypes for AFAP1:
genes like me logo Genes that share phenotypes with AFAP1: view

miRNA for AFAP1 Gene

miRTarBase miRNAs that target AFAP1

No data available for Enzyme Numbers (IUBMB) , Animal Models , Transcription Factor Targeting and HOMER Transcription for AFAP1 Gene

Localization for AFAP1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for AFAP1 Gene

Cytoplasm, cytoskeleton. Note=Localizes with stress fibers in quiescent cells, concentrated in cell motility structures such as lamellipodia, filopodia and membrane ruffles upon their induction.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for AFAP1 Gene COMPARTMENTS Subcellular localization image for AFAP1 gene
Compartment Confidence
cytoskeleton 5
cytosol 3
nucleus 2
mitochondrion 1

Gene Ontology (GO) - Cellular Components for AFAP1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm IDA --
GO:0005856 cytoskeleton --
GO:0005925 focal adhesion IDA --
GO:0015629 actin cytoskeleton IDA --
genes like me logo Genes that share ontologies with AFAP1: view

Pathways for AFAP1 Gene

genes like me logo Genes that share pathways with AFAP1: view

Pathways by source for AFAP1 Gene

1 GeneGo (Thomson Reuters Life Sciences Research) pathway for AFAP1 Gene

Gene Ontology (GO) - Biological Process for AFAP1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0009966 regulation of signal transduction IEA --
GO:0051493 regulation of cytoskeleton organization IEA --
genes like me logo Genes that share ontologies with AFAP1: view

Compounds for AFAP1 Gene

(2) Novoseek inferred chemical compound relationships for AFAP1 Gene

Compound -log(P) Hits PubMed IDs
leucine 41.6 4
tyrosine 34 7
genes like me logo Genes that share compounds with AFAP1: view

Transcripts for AFAP1 Gene

Unigene Clusters for AFAP1 Gene

Actin filament associated protein 1:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for AFAP1 Gene

ExUns: 1a · 1b ^ 2a · 2b ^ 3a · 3b ^ 4 ^ 5 ^ 6a · 6b ^ 7 ^ 8a · 8b · 8c · 8d ^ 9a · 9b · 9c · 9d ^ 10 ^ 11 ^ 12 ^ 13 ^ 14 ^ 15 ^ 16 ^
SP1: - - - - -
SP2: - -
SP3: - -
SP4: - - - - - - -
SP5: -
SP6:
SP7:
SP8: - -
SP9: - -
SP10: - -
SP11:
SP12:

ExUns: 17 ^ 18 ^ 19 ^ 20 ^ 21 ^ 22 ^ 23a · 23b
SP1:
SP2:
SP3:
SP4:
SP5:
SP6:
SP7: -
SP8:
SP9:
SP10:
SP11:
SP12:

Relevant External Links for AFAP1 Gene

GeneLoc Exon Structure for
AFAP1
ECgene alternative splicing isoforms for
AFAP1

Expression for AFAP1 Gene

mRNA expression in normal human tissues for AFAP1 Gene

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for AFAP1 Gene

SOURCE GeneReport for Unigene cluster for AFAP1 Gene Hs.529369

mRNA Expression by UniProt/SwissProt for AFAP1 Gene

Q8N556-AFAP1_HUMAN
Tissue specificity: Low expression in normal breast epithelial cell line MCF-10A and in tumorigenic breast cancer cell lines MCF-7, T-47D and ZR-75-1. Highly expressed in the invasive breast cancer cell lines MDA-MB-231 and MDA-MB-435. Overexpressed in prostate carcinoma.
genes like me logo Genes that share expressions with AFAP1: view

Orthologs for AFAP1 Gene

This gene was present in the common ancestor of chordates.

Orthologs for AFAP1 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia AFAP1 36
  • 99.43 (n)
  • 99.75 (a)
AFAP1 37
  • 100 (a)
OneToOne
cow
(Bos Taurus)
Mammalia AFAP1 36
  • 83.67 (n)
  • 89.64 (a)
AFAP1 37
  • 89 (a)
OneToOne
dog
(Canis familiaris)
Mammalia AFAP1 36
  • 80.9 (n)
  • 86.21 (a)
AFAP1 37
  • 88 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Afap1 36
  • 84.22 (n)
  • 91.41 (a)
Afap1 16
Afap1 37
  • 92 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia AFAP1 37
  • 89 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia AFAP1 37
  • 72 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Afap1 36
  • 82.75 (n)
  • 89.28 (a)
chicken
(Gallus gallus)
Aves AFAP1 36
  • 79.4 (n)
  • 87.39 (a)
AFAP1 37
  • 85 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia AFAP1 37
  • 82 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia afap1 36
  • 73.81 (n)
  • 79.06 (a)
zebrafish
(Danio rerio)
Actinopterygii afap1 36
  • 68.35 (n)
  • 71.46 (a)
afap1 37
  • 70 (a)
OneToOne
Species with no ortholog for AFAP1:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for AFAP1 Gene

ENSEMBL:
Gene Tree for AFAP1 (if available)
TreeFam:
Gene Tree for AFAP1 (if available)

Paralogs for AFAP1 Gene

Paralogs for AFAP1 Gene

Selected SIMAP similar genes for AFAP1 Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with AFAP1: view

Variants for AFAP1 Gene

Sequence variations from dbSNP and Humsavar for AFAP1 Gene

SNP ID Clin Chr 04 pos Sequence Context AA Info Type MAF
rs756255 -- 7,798,972(-) CAATG(A/C)GGGTC intron-variant
rs877706 -- 7,791,134(-) TGCCC(A/G)TTTAA intron-variant
rs877707 -- 7,790,935(-) CACCC(A/G)GCTAA intron-variant
rs885260 -- 7,811,320(+) CCACC(C/G)CAGGA intron-variant
rs885261 -- 7,811,393(+) ACGAC(A/G)CGCCC intron-variant

Structural Variations from Database of Genomic Variants (DGV) for AFAP1 Gene

Variant ID Type Subtype PubMed ID
esv34196 OTHER Inversion 12058347
nsv878570 CNV Gain 21882294
nsv878575 CNV Loss 21882294
nsv878577 CNV Loss 21882294
nsv822468 CNV Gain 20364138
esv2727079 CNV Deletion 23290073
esv34140 CNV Loss 18971310
esv2657565 CNV Deletion 23128226
esv2727080 CNV Deletion 23290073
esv2672788 CNV Deletion 23128226
esv2727081 CNV Deletion 23290073
esv2727082 CNV Deletion 23290073
esv2144252 CNV Deletion 18987734
nsv291019 CNV Loss 16902084
nsv522369 CNV Gain 19592680
esv2727083 CNV Deletion 23290073
esv23167 CNV Gain+Loss 19812545
nsv820965 CNV Deletion 20802225
esv2727085 CNV Deletion 23290073
esv2727086 CNV Deletion 23290073
nsv508996 CNV Insertion 20534489
nsv878578 CNV Gain 21882294
esv2491294 CNV Insertion 19546169
esv8707 CNV Gain 19470904
esv2727087 CNV Deletion 23290073
esv2743363 CNV Deletion 23290073
esv2727088 CNV Deletion 23290073
esv2727089 CNV Deletion 23290073
esv2727090 CNV Deletion 23290073
nsv291213 CNV Loss 16902084
esv2143898 CNV Deletion 18987734
esv2727091 CNV Deletion 23290073
esv2727092 CNV Deletion 23290073
esv2727093 CNV Deletion 23290073
esv22994 CNV Gain 19812545
esv2727094 CNV Deletion 23290073
esv2668272 CNV Deletion 23128226
esv2727096 CNV Deletion 23290073

Relevant External Links for AFAP1 Gene

HapMap Linkage Disequilibrium report
AFAP1

Disorders for AFAP1 Gene

Relevant External Links for AFAP1

Genetic Association Database (GAD)
AFAP1
genes like me logo Genes that share disorders with AFAP1: view

No data available for UniProtKB/Swiss-Prot for AFAP1 Gene

Publications for AFAP1 Gene

  1. The actin filament-associated protein AFAP-110 is an adaptor protein that modulates changes in actin filament integrity. (PMID: 11607843) Baisden J.M. … Flynn D.C. (Oncogene 2001) 2 3 23
  2. The intrinsic ability of AFAP-110 to alter actin filament integrity is linked with its ability to also activate cellular tyrosine kinases. (PMID: 11641786) Baisden J.M. … Flynn D.C. (Oncogene 2001) 2 3 23
  3. Analysis of the role of the leucine zipper motif in regulating the ability of AFAP-110 to alter actin filament integrity. (PMID: 14755689) Qian Y. … Flynn D.C. (J. Cell. Biochem. 2004) 2 3 23
  4. AFAP-110 is required for actin stress fiber formation and cell adhesion in MDA-MB-231 breast cancer cells. (PMID: 17520695) Dorfleutner A. … Flynn D.C. (J. Cell. Physiol. 2007) 3 4 23
  5. Conversion of mechanical force into biochemical signaling. (PMID: 15485829) Han B. … Liu M. (J. Biol. Chem. 2004) 4 23

Products for AFAP1 Gene

Sources for AFAP1 Gene

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