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AFAP1 Gene

protein-coding   GIFtS: 55
GCID: GC04M007682

Actin Filament Associated Protein 1

  Search for AFAP1
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Actin Filament Associated Protein 11 2     AFAP1102 5
AFAP2 3 5     Actin Filament-Associated Protein 12
110 KDa Actin Filament-Associated Protein2 3     Actin Filament-Associated Protein, 110 KDa2
AFAP-1102 3     

External Ids:    HGNC: 240171   Entrez Gene: 603122   Ensembl: ENSG000001965267   OMIM: 6082525   UniProtKB: Q8N5563   

Export aliases for AFAP1 gene to outside databases

Previous GC identifer: GC04M007811


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for AFAP1 Gene:
The protein encoded by this gene is a Src binding partner. It may represent a potential modulator of actin
filament integrity in response to cellular signals, and may function as an adaptor protein by linking Src family
members and/or other signaling proteins to actin filaments. Multiple transcript variants encoding different
isoforms have been found for this gene. (provided by RefSeq, Aug 2008)

GeneCards Summary for AFAP1 Gene:
AFAP1 (actin filament associated protein 1) is a protein-coding gene. GO annotations related to this gene include actin binding and phospholipid binding. An important paralog of this gene is AFAP1L2.

UniProtKB/Swiss-Prot: AFAP1_HUMAN, Q8N556
Function: Can cross-link actin filaments into both network and bundle structures (By similarity). May modulate
changes in actin filament integrity and induce lamellipodia formation. May function as an adapter molecule that
links other proteins, such as SRC and PKC to the actin cytoskeleton. Seems to play a role in the development and
progression of prostate adenocarcinoma by regulating cell-matrix adhesions and migration in the cancer cells

Gene Wiki entry for AFAP1 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000004.11  NT_006051.19  NC_018915.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the AFAP1 gene promoter:
         Sox5   Sp1   Pax-6   MEF-2A   CREB   SRY   deltaCREB   Sox9   aMEF-2   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidAFAP1 promoter sequence
   Search Chromatin IP Primers for AFAP1

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat AFAP1


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 4p16   Ensembl cytogenetic band:  4p16.1   HGNC cytogenetic band: 4p16

AFAP1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
AFAP1 gene location

GeneLoc information about chromosome 4         GeneLoc Exon Structure

GeneLoc location for GC04M007682:  view genomic region     (about GC identifiers)

Start:
7,760,440 bp from pter      End:
7,941,653 bp from pter
Size:
181,214 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., and/or eBioscience,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., and/or eBioscience, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: AFAP1_HUMAN, Q8N556 (See protein sequence)
Recommended Name: Actin filament-associated protein 1  
Size: 730 amino acids; 80725 Da
Subunit: Monomer and homomultimer. Interacts via its C-terminus with F-actin; probably involving AFAP1 multimers
(By similarity). Interacts with activated SRC SH3-SH2 domains. Interacts via its PH 1 domain with PRKCA, PRKCB
and PRKCI (By similarity)
Miscellaneous: Knockdown in MDA-MB-231 cells resulted in loss of actin stress fibers, decreased adhesion and
spreading on fibronectin
Secondary accessions: A8K442 B4DMU2 E9PDT7 Q59EY5 Q9HBY1
Alternative splicing: 2 isoforms:  Q8N556-1   Q8N556-2   (No experimental confirmation available. Ref.2 (BAG60004) sequence is in conflict in position: 561:A->V)

Explore the universe of human proteins at neXtProt for AFAP1: NX_Q8N556

Explore proteomics data for AFAP1 at MOPED

Post-translational modifications: 

  • Phosphorylated on tyrosine residues by SRC1
  • Modification sites at neXtProt
  • Modification sites at PhosphoSitePlus

  • See AFAP1 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (2 alternative transcripts): 
    NP_001128119.1  NP_940997.1  

    ENSEMBL proteins: 
     ENSP00000353402   ENSP00000371983   ENSP00000410689   ENSP00000351245  

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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    PLEKH: Pleckstrin homology (PH) domain containing

    2 InterPro protein domains:
     IPR001849 Pleckstrin_homology
     IPR011993 PH_like_dom

    Graphical View of Domain Structure for InterPro Entry Q8N556

    ProtoNet protein and cluster: Q8N556

    1 Blocks protein domain: IPB001849 Pleckstrin-like

    UniProtKB/Swiss-Prot: AFAP1_HUMAN, Q8N556
    Similarity: Contains 2 PH domains


    Find genes that share domains with AFAP1           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: AFAP1_HUMAN, Q8N556
    Function: Can cross-link actin filaments into both network and bundle structures (By similarity). May modulate
    changes in actin filament integrity and induce lamellipodia formation. May function as an adapter molecule that
    links other proteins, such as SRC and PKC to the actin cytoskeleton. Seems to play a role in the development and
    progression of prostate adenocarcinoma by regulating cell-matrix adhesions and migration in the cancer cells

         Gene Ontology (GO): 1 molecular function term:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003779actin binding IEA--
         
    Find genes that share ontologies with AFAP1           About GenesLikeMe


    Phenotypes:
         1 GenomeRNAi human phenotype for AFAP1:
     High actin ratio cells 

    Animal Models:
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    Selected qRT-PCR Assays for microRNAs that regulate AFAP1 (see all 46):
    hsa-miR-513a-5p hsa-miR-128 hsa-miR-25 hsa-let-7a-2* hsa-miR-570 hsa-miR-4275 hsa-miR-183* hsa-miR-9
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    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    AFAP1_HUMAN, Q8N556: Cytoplasm, cytoskeleton. Note=Localizes with stress fibers in quiescent cells, concentrated
    in cell motility structures such as lamellipodia, filopodia and membrane ruffles upon their induction
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    cytoskeleton5
    cytosol3
    nucleus2
    mitochondrion1

    Gene Ontology (GO): 4 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005737cytoplasm IEA--
    GO:0005856cytoskeleton IEA--
    GO:0005925focal adhesion ----
    GO:0015629actin cytoskeleton ----

    Find genes that share ontologies with AFAP1           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for AFAP1 About    
    See pathways by source

    SuperPathContained pathways About
    1Immune response IFN gamma signaling pathway
    Immune response IFN gamma signaling pathway0.43

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways


    1 GeneGo (Thomson Reuters) Pathway for AFAP1
        Immune response IFN gamma signaling pathway


        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for AFAP1
    Interactions:

        GeneGlobe Interaction Network for AFAP1

    STRING Interaction Network Preview (showing 5 interactants - click image to see 10)

    Selected Interacting proteins for AFAP1 (Q8N5563 ENSP000004106894) via UniProtKB, MINT, STRING, and/or I2D (see all 10)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    PRKCBP057713, ENSP000003053554I2D: score=3 STRING: ENSP00000305355
    PRKCDQ056553, ENSP000003316024I2D: score=3 STRING: ENSP00000331602
    PRKCGP051293, ENSP000002634314I2D: score=3 STRING: ENSP00000263431
    ACTC1P680323, ENSP000002903784I2D: score=2 STRING: ENSP00000290378
    PRKCZQ055133, ENSP000003678304I2D: score=2 STRING: ENSP00000367830
    About this table

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for AFAP1

    2 Novoseek inferred chemical compound relationships for AFAP1 gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    leucine 41.6 4 11641786 (1), 14755689 (1), 10380016 (1), 11607843 (1)
    tyrosine 34 8 11641786 (2), 15314167 (2), 15485829 (1), 11607843 (1) (see all 5)



    Find genes that share compounds with AFAP1           About GenesLikeMe



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for AFAP1 gene (3 alternative transcripts): 
    NM_001134647.1  NM_198595.2  NM_021638.4  

    Unigene Cluster for AFAP1:

    Actin filament associated protein 1
    Hs.529369  [show with all ESTs]
    Unigene Representative Sequence: NM_001134647
    8 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000360265 ENST00000505447 ENST00000513842 ENST00000382543 ENST00000508415
    ENST00000513856 ENST00000420658(uc011bwk.1) ENST00000358461(uc003gkg.1)

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    hsa-miR-513a-5p hsa-miR-128 hsa-miR-25 hsa-let-7a-2* hsa-miR-570 hsa-miR-4275 hsa-miR-183* hsa-miR-9
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    Additional mRNA sequence: 

    AB209676.1 AF188700.1 AK127962.1 AK290807.1 AK297631.1 BC015900.1 BC032777.1 D25248.1 
    XR_112616.1 

    6 DOTS entries:

    DT.97822158  DT.215914  DT.101956502  DT.121232595  DT.92067800  DT.100829322 

    Selected AceView cDNA sequences (see all 126):

    CB217097 AI085991 R43661 F06246 AI188460 CR606819 BU186955 F02531 
    F08751 AA292097 BC032777 BU164761 D57870 BU616014 AW151921 AI291099 
    BU686680 BQ182989 AI468446 NM_198595 BF036843 BX950996 NM_021638 AA322072 

    GeneLoc Exon Structure

    Selected Alternative Splicing Database (ASD) splice patterns (SP) for AFAP1 (see all 12)    About this scheme

    ExUns: 1a · 1b ^ 2a · 2b ^ 3a · 3b ^ 4 ^ 5 ^ 6a · 6b ^ 7 ^ 8a · 8b · 8c · 8d ^ 9a · 9b · 9c · 9d ^ 10 ^ 11 ^ 12 ^ 13 ^ 14 ^ 15 ^ 16 ^
    SP1:              -     -                       -                 -                       -                                                                     
    SP2:                                            -                 -                                                                                             
    SP3:                                                              -                       -                                                                     
    SP4:              -     -           -     -     -                 -                       -                                                                     
    SP5:                                                                                                                                                  -         

    ExUns: 17 ^ 18 ^ 19 ^ 20 ^ 21 ^ 22 ^ 23a · 23b
    SP1:                                                
    SP2:                                                
    SP3:                                                
    SP4:                                                
    SP5:                                                


    ECgene alternative splicing isoforms for AFAP1

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    AFAP1 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: GTGATACGTT
    AFAP1 Expression
    About this image

    AFAP1 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    AFAP1 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.529369

    UniProtKB/Swiss-Prot: AFAP1_HUMAN, Q8N556
    Tissue specificity: Low expression in normal breast epithelial cell line MCF-10A and in tumorigenic breast cancer
    cell lines MCF-7, T-47D and ZR-75-1. Highly expressed in the invasive breast cancer cell lines MDA-MB-231 and
    MDA-MB-435. Overexpressed in prostate carcinoma

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    In Situ
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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of chordates.

    Orthologs for AFAP1 gene from Selected species (see all 11)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Afap11 , 5 actin filament associated protein 11, 5 84.22(n)1
    91.41(a)1
      5 (19.02 cM)5
    702921  NM_027373.21  NP_081649.11 
     358933195 
    chicken
    (Gallus gallus)
    Aves AFAP11 actin filament associated protein 1 79.4(n)
    87.39(a)
      374034  NM_204205.1  NP_989536.1 
    lizard
    (Anolis carolinensis)
    Reptilia AFAP16
    actin filament associated protein 1
    82(a)
    1 ↔ 1
    4(79727093-79800906)
    tropical clawed frog
    (Xenopus tropicalis)
    Amphibia afap11 actin filament associated protein 1 73.81(n)
    79.06(a)
      779522  XM_004911244.1  XP_004911301.1 
    zebrafish
    (Danio rerio)
    Actinopterygii afap11 actin filament associated protein 1 68.35(n)
    71.46(a)
      568356  XM_005156227.1  XP_005156284.1 


    ENSEMBL Gene Tree for AFAP1 (if available)
    TreeFam Gene Tree for AFAP1 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for AFAP1 gene
    AFAP1L22  AFAP1L12  
    2 SIMAP similar genes for AFAP1 using alignment to 1 protein entry:     AFAP1_HUMAN:
    AFAP1L1    AFAP1L2

    Find genes that share paralogs with AFAP1           About GenesLikeMe



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for AFAP1 (see all 4780)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 4 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1512565971,2
    --7781310(+) ATCCAC/TGCCCA 2 -- int10--------
    rs1144307831,2
    C,F--7781317(+) CCCACG/ACTTTT 2 -- int11Minor allele frequency- A:0.03WA 118
    rs109378601,2
    C,F--7781329(+) TCCACG/CATACA 2 -- int18Minor allele frequency- C:0.13NA WA EA 504
    rs1404529221,2
    --7781358(+) CCTCAC/TTTTTT 2 -- int10--------
    rs100150311,2
    C--7781399(+) GGCTCT/CATCAA 2 -- int15Minor allele frequency- C:0.14NA WA EA 362
    rs1148654161,2
    C,F--7781403(+) CTATCA/GATCAT 2 -- int11Minor allele frequency- G:0.03WA 118
    rs1504746861,2
    --7781497(+) GTTCCG/TAAAAA 2 -- int10--------
    rs100251541,2
    C,F,H--7781560(+) AAAGTG/ACAAGG 2 -- int112Minor allele frequency- A:0.09NA NS EA WA 910
    rs1160014311,2
    F--7781659(+) CCTATT/CTCAAC 2 -- int11Minor allele frequency- C:0.02WA 118
    rs1477484171,2
    --7781729(+) ATGATC/TCCCAA 2 -- int10--------

    HapMap Linkage Disequilibrium report for AFAP1 (7760440 - 7941653 bp)

    Structural Variations
         Database of Genomic Variants (DGV) Selected variations for AFAP1 (see all 38):    About this table    
    Variant IDTypeSubtypePubMed ID
    esv2727091CNV Deletion23290073
    esv2727096CNV Deletion23290073
    esv2727081CNV Deletion23290073
    esv2143898CNV Deletion18987734
    esv2727092CNV Deletion23290073
    esv2727089CNV Deletion23290073
    esv2144252CNV Deletion18987734
    esv2727079CNV Deletion23290073
    esv2727080CNV Deletion23290073
    nsv820965CNV Deletion20802225

    Site Specific Mutation Identification with PCR Assays
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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section

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    OMIM gene information: 608252    OMIM disorders: --


    Find genes that share disorders with AFAP1           About GenesLikeMe

    Genetic Association Database (GAD): AFAP1

    Export disorders for AFAP1 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for AFAP1 gene, integrated from 10 sources (see all 47):
    (articles sorted by number of sources associating them with AFAP1)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. AFAP-110 is required for actin stress fiber formation and cell adhesion in MDA-MB-231 breast cancer cells. (PubMed id 17520695)1, 2, 9 Dorfleutner A.... Flynn D.C. (J. Cell. Physiol. 2007)
    2. The intrinsic ability of AFAP-110 to alter actin filament integrity is linked with its ability to also activate cellular tyrosine kinases. (PubMed id 11641786)1, 3, 9 Baisden J.M....Flynn D.C. (Oncogene 2001)
    3. The actin filament-associated protein AFAP-110 is an adaptor protein that modulates changes in actin filament integrity. (PubMed id 11607843)1, 3, 9 Baisden J.M....Flynn D.C. (Oncogene 2001)
    4. Analysis of the role of the leucine zipper motif in regulating the ability of AFAP-110 to alter actin filament integrity. (PubMed id 14755689)1, 3, 9 Qian Y....Flynn D.C. (J. Cell. Biochem. 2004)
    5. AFAP-110 is overexpressed in prostate cancer and contributes to tumorigenic growth by regulating focal contacts. (PubMed id 17885682)2, 9 Zhang J.... Gallick G.E. (J. Clin. Invest. 2007)
    6. Conversion of mechanical force into biochemical signaling. (PubMed id 15485829)2, 9 Han B....Liu M. (J. Biol. Chem. 2004)
    7. Hypomethylation of noncoding DNA regions and overexpression of the long noncoding RNA, AFAP1-AS1, in Barrett's esophagus and esophageal adenocarcinoma. (PubMed id 23333711)1 Wu W....Meltzer S.J. (Gastroenterology 2013)
    8. N-terminal acetylome analyses and functional insights of the N- terminal acetyltransferase NatB. (PubMed id 22814378)2 Van Damme P....Aldabe R. (Proc. Natl. Acad. Sci. U.S.A. 2012)
    9. System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation. (PubMed id 21406692)2 Rigbolt K.T....Blagoev B. (Sci. Signal. 2011)
    10. Proteomic profiling of Myc-associated proteins. (PubMed id 21150319)1 Agrawal P....Sedivy J.M. (Cell Cycle 2010)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 60312 HGNC: 24017 AceView: AFAP Ensembl:ENSG00000196526 euGenes: HUgn60312
    ECgene: AFAP1 H-InvDB: AFAP1

    (According to HUGE)
    About This Section

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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
    About This Section

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    NameDescription
    PharmGKB entry for AFAP1 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section

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    Patent Information for AFAP1 gene:
    Search GeneIP for patents involving AFAP1

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, eBioscience, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
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