AFAP1 Gene
protein-coding GIFtS : 54
GCID: GC04 M007682
actin filament associated protein 1
Jump to Section...
Aliases
Databases
Disorders / Diseases
Domains / Families
Drugs / Compounds
Expression
Function
Genomic Views
Intellectual Property
Orthologs
Paralogs
Pathways / Interactions
Products
Proteins
Publications
Search Box
Summaries
Transcripts
Variants
TOP
BOTTOM
Aliasesfor AFAP1 gene
(According to
1 HGNC ,
2 Entrez Gene ,
3 UniProtKB/Swiss-Prot ,
4 UniProtKB/TrEMBL , 5 OMIM , 6 GeneLoc ,
7 Ensembl ,
8 DME ,
9 miRBase ,
and/or 10 fRNAdb )About This Section Aliases Actin Filament Associated Protein 1 1 2 AFAP1102 AFAP1 2 3 Actin Filament-Associated Protein 12 AFAP-1101 2 3 Actin Filament-Associated Protein, 110 KDa2 110 KDa Actin Filament-Associated Protein2 3
Export aliases for AFAP1 gene to outside databases Previous GC identifer: GC04M007811
Jump to Section...
Aliases
Databases
Disorders / Diseases
Domains / Families
Drugs / Compounds
Expression
Function
Genomic Views
Intellectual Property
Orthologs
Paralogs
Pathways / Interactions
Products
Proteins
Publications
Search Box
Summaries
Transcripts
Variants
TOP
BOTTOM
Summariesfor AFAP1 gene (According to Entrez Gene ,
Tocris Bioscience ,
Wikipedia's
Gene Wiki ,
PharmGKB ,
UniProtKB/Swiss-Prot ,
and/or
UniProtKB/TrEMBL )
About This Section Entrez Gene summary for AFAP1 : The protein encoded by this gene is a Src binding partner. It may represent a potential modulator of actin filament integrity in response to cellular signals, and may function as an adaptor protein by linking Src family members and/or other signaling proteins to actin filaments. Multiple transcript variants encoding different isoforms have been found for this gene. (provided by RefSeq, Aug 2008) UniProtKB/Swiss-Prot: AFAP1_HUMAN, Q8N556 Function : Can cross-link actin filaments into both network and bundle structures (By similarity). May modulate changesin actin filament integrity and induce lamellipodia formation. May function as an adapter molecule that links other proteins, such as SRC and PKC to the actin cytoskeleton. Seems to play a role in the development and progression of prostate adenocarcinoma by regulating cell-matrix adhesions and migration in the cancer cells Gene Wiki entry for AFAP1
Jump to Section...
Aliases
Databases
Disorders / Diseases
Domains / Families
Drugs / Compounds
Expression
Function
Genomic Views
Intellectual Property
Orthologs
Paralogs
Pathways / Interactions
Products
Proteins
Publications
Search Box
Summaries
Transcripts
Variants
TOP
BOTTOM
Genomic Viewsfor AFAP1 gene
(According to
GeneLoc and/or
HGNC , and/or
Entrez Gene (NCBI build 37) ,
and/or miRBase ,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69) ,
Regulatory elements and Epigenetics data according to
QIAGEN ,
SABiosciences , and/or
SwitchGear Genomics )About This Section RefSeq DNA sequence: NC_000004.11 NC_018915.1 NT_006051.18 Regulatory elements: SABiosciences Regulatory transcription factor binding sites in the AFAP1 gene promoter: Sox5 Sp1 Pax-6 MEF-2A CREB SRY deltaCREB Sox9 aMEF-2 Other transcription factors Search SABiosciences Chromatin IP Primers for AFAP1 Epigenetics: QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat AFAP1
Genomic Location: Genomic View : UCSC Golden Path with GeneCards custom track Entrez Gene cytogenetic band: 4p16 Ensembl cytogenetic band: 4p16.1 HGNC cytogenetic band: 4p16 AFAP1 Gene in genomic location: bands according to Ensembl, locations according to
(and/or Entrez Gene and/or Ensembl if different) GeneLoc information about chromosome 4 GeneLoc Exon Structure
GeneLoc location for GC04M007682: view genomic region
(about GC identifiers )
Start:
7,760,440 bp from pter
End:
7,941,653 bp from pter
Size:
181,214 bases
Orientation:
minus strand
Jump to Section...
Aliases
Databases
Disorders / Diseases
Domains / Families
Drugs / Compounds
Expression
Function
Genomic Views
Intellectual Property
Orthologs
Paralogs
Pathways / Interactions
Products
Proteins
Publications
Search Box
Summaries
Transcripts
Variants
TOP
BOTTOM
Proteinsfor AFAP1 gene
(According to
1 UniProtKB ,
HORDE ,
neXtProt ,
Ensembl ,
and/or Reactome ,
Modification sites according to 2 PhosphoSitePlus ,
Specific Peptides from DME ,
Protein expression images according to data from SPIRE MOPED and PaxDb ,
RefSeq according to NCBI ,
PDB rendering according to OCA and/or Proteopedia ,
Recombinant Proteins
from
EMD Millipore ,
R&D Systems ,
GenScript ,
Enzo Life Sciences ,
OriGene ,
Novus Biologicals ,
Sino Biological ,
ProSpec , and/or
Uscn ,
Biochemical Assays by
EMD Millipore ,
R&D Systems ,
OriGene ,
GenScript ,
Cell Signaling Technology ,
Enzo Life Sciences , and/or
Uscn ,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene ,
Antibodies by
EMD Millipore ,
R&D Systems ,
GenScript ,
Cell Signaling Technology ,
OriGene ,
Novus Biologicals ,
Thermo Fisher Scientific ,
Abcam , and/or
Uscn )
About This Section UniProtKB/Swiss-Prot: AFAP1_HUMAN, Q8N556 (See
protein sequence )Recommended Name: Actin filament-associated protein 1 Size : 730 amino acids; 80725 Da
Subunit : Monomer and homomultimer. Interacts via its C-terminus with F-actin; probably involving AFAP1 multimers (Bysimilarity). Interacts with activated SRC SH3-SH2 domains. Interacts via its PH 1 domain with PRKCA, PRKCB and PRKCI (By similarity)
Subcellular location : Cytoplasm, cytoskeleton. Note=Localizes with stress fibers in quiescent cells, concentrated incell motility structures such as lamellipodia, filopodia and membrane ruffles upon their induction
Miscellaneous : Knockdown in MDA-MB-231 cells resulted in loss of actin stress fibers, decreased adhesion and spreadingon fibronectin
Secondary accessions : A8K442 B4DMU2 E9PDT7 Q59EY5 Q9HBY1Alternative splicing : 2 isoforms : Q8N556-1 Q8N556-2 (No experimental confirmation available. Ref.2 (BAG60004) sequence is in conflict in position: 561:A->V)Explore the universe of human proteins at neXtProt for AFAP1: NX_Q8N556 Post-translational modifications:
Phosphorylated on tyrosine residues by SRC1
View modification sites using PhosphoSitePlus 2 View neXtProt modification sites for NX_Q8N556 AFAP1 Protein expression data from MOPED and PaxDb : About this image
REFSEQ proteins (2 alternative transcripts):
NP_001128119.1 NP_940997.1 ENSEMBL proteins: ENSP00000353402 ENSP00000371983 ENSP00000410689 ENSP00000351245 Human Recombinant Protein Products: Gene Ontology (GO): 4 cellular component terms (GO ID links to tree view) : About this table
AFAP1 for ontologies About GeneDecksing AFAP1 Antibody Products: Assay Products for AFAP1:
Jump to Section...
Aliases
Databases
Disorders / Diseases
Domains / Families
Drugs / Compounds
Expression
Function
Genomic Views
Intellectual Property
Orthologs
Paralogs
Pathways / Interactions
Products
Proteins
Publications
Search Box
Summaries
Transcripts
Variants
TOP
BOTTOM
Protein
Domains / Familiesfor AFAP1 gene (According to InterPro , ProtoNet ,
UniProtKB , and/or BLOCKS ,
Sets of similar genes according to GeneDecks )
About This Section
AFAP1 for domains About GeneDecksing 2 InterPro domains/families :
Graphical View of Domain Structure for InterPro Entry Q8N556 ProtoNet protein and cluster: Q8N556
1 Blocks protein family : IPB001849 Pleckstrin-like UniProtKB/Swiss-Prot: AFAP1_HUMAN, Q8N556 Similarity : Contains 2 PH domains
Jump to Section...
Aliases
Databases
Disorders / Diseases
Domains / Families
Drugs / Compounds
Expression
Function
Genomic Views
Intellectual Property
Orthologs
Paralogs
Pathways / Interactions
Products
Proteins
Publications
Search Box
Summaries
Transcripts
Variants
TOP
BOTTOM
Functionfor AFAP1 gene
(According to 1 UniProtKB ,
Genatlas ,
LifeMap Discovery™ ,
IUBMB , and/or
2 DME ,
Human phenotypes from GenomeRNAi ,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences ,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene ,
RNAi from
EMD Millipore ,
siRNAs from
OriGene ,
QIAGEN ,
microRNA from QIAGEN ,
Gene Editing from DNA2.0 ,
Clones from EMD Millipore ,
OriGene ,
SwitchGear Genomics ,
GenScript ,
Sino Biological ,
DNA2.0 ,
and Vector BioLabs ,
Cell Lines from GenScript ,
LifeMap BioReagents ,
In Situ Hybridization Assays from Advanced Cell Diagnostics ,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene .)
About This Section Function Summary: UniProtKB/Swiss-Prot: AFAP1_HUMAN, Q8N556 Function : Can cross-link actin filaments into both network and bundle structures (By similarity). May modulate changesin actin filament integrity and induce lamellipodia formation. May function as an adapter molecule that links other proteins, such as SRC and PKC to the actin cytoskeleton. Seems to play a role in the development and progression of prostate adenocarcinoma by regulating cell-matrix adhesions and migration in the cancer cells
Clone Products: Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human , mouse , rat for AFAP1 (see all 5 ) OriGene untagged cDNA clones in CMV expression vector in human , mouse , rat for AFAP1 (see all 3 )OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling GenScript: all cDNA clones in your preferred vector (see all 2 ): AFAP1 (NM_198595 ) Browse Sino Biological Human cDNA Clones DNA2.0 Custom Codon Optimized Gene
Synthesis Service for AFAP1 Vector BioLabs ready-to-use adenovirus/AAV for human , mouse , rat AFAP1
In Situ Assay Products: Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for AFAP1
Gene Ontology (GO): 5 molecular function terms (GO ID links to tree view) : About this table
AFAP1 for ontologies About GeneDecksing 1 GenomeRNAi human phenotype for AFAP1 :
Jump to Section...
Aliases
Databases
Disorders / Diseases
Domains / Families
Drugs / Compounds
Expression
Function
Genomic Views
Intellectual Property
Orthologs
Paralogs
Pathways / Interactions
Products
Proteins
Publications
Search Box
Summaries
Transcripts
Variants
TOP
BOTTOM
Pathways & Interactionsfor AFAP1 gene
(Pathways according to
EMD Millipore ,
R&D Systems ,
Cell Signaling Technology ,
KEGG ,
PharmGKB ,
BioSystems ,
Reactome ,
Tocris Bioscience ,
GeneGo (Thomson Reuters) ,
QIAGEN ,
and/or UniProtKB ,
Sets of similar genes according to GeneDecks ,
Interaction Networks according to
SABiosciences ,
and/or STRING ,
Interactions according to 1 UniProtKB ,
2 MINT ,
3 I2D , and/or
4 STRING ,
with links to IntAct and
Ensembl ,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene) .
About This Section Unified GeneCards pathways   About this table See pathways by source Super-pathway contained gene-specific pathways 1 Immune response_IFN gamma signaling pathway
Pathway sources See GeneCards unified pathways Show all pathways 1 EMD Millipore Pathway for AFAP1 1 GeneGo (Thomson Reuters) Pathway for AFAP1
AFAP1 for pathways About GeneDecksing Interactions: SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for AFAP1 STRING Interaction
Network Preview (showing 5 interactants - click image to see 10)5/10 Interacting proteins for AFAP1 (Q8N556 3 ENSP00000410689 4 ) via UniProtKB, MINT, STRING , and/or I2D (see all 10 )About this table Gene Ontology (GO): 2 biological process terms (GO ID links to tree view) : About this table
GO ID Qualified GO term Evidence PubMed IDs GO:0009966 regulation of signal transduction
-- -- GO:0071260 cellular response to mechanical stimulus
-- --
AFAP1 for ontologies About GeneDecksing
Jump to Section...
Aliases
Databases
Disorders / Diseases
Domains / Families
Drugs / Compounds
Expression
Function
Genomic Views
Intellectual Property
Orthologs
Paralogs
Pathways / Interactions
Products
Proteins
Publications
Search Box
Summaries
Transcripts
Variants
TOP
BOTTOM
Drugs & Compoundsfor AFAP1 gene (Chemical Compounds according to UniProtKB , Enzo Life Sciences ,
EMD Millipore , Tocris Bioscience
HMDB ,
BitterDB , and/or
Novoseek , and Drugs according to
DrugBank ,
Enzo Life Sciences , and/or
PharmGKB , with drugs/clinical trials/news
search links to CenterWatch )
About This Section
AFAP1 for compounds About GeneDecksing Browse Tocris compounds for AFAP1 2 Novoseek chemical compound relationships for AFAP1 gene About this table
Search CenterWatch for drugs/clinical trials and news about AFAP1
Jump to Section...
Aliases
Databases
Disorders / Diseases
Domains / Families
Drugs / Compounds
Expression
Function
Genomic Views
Intellectual Property
Orthologs
Paralogs
Pathways / Interactions
Products
Proteins
Publications
Search Box
Summaries
Transcripts
Variants
TOP
BOTTOM
Transcriptsfor AFAP1 gene (Secondary structures according to
fRNAdb ,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank , RefSeq according to Entrez Gene ,
DOTS (version 10), and/or
AceView ,
transcript ids from Ensembl
with links to UCSC ,
exon structure from GeneLoc ,
alternative splicing isoforms according to ASD and/or
ECgene ,
RNAi Products from
EMD Millipore ,
siRNAs from
OriGene ,
QIAGEN ,
shRNA from
OriGene ,
microRNA from QIAGEN ,
Tagged/untagged cDNA clones from
OriGene ,
SwitchGear Genomics ,
GenScript ,
DNA2.0 ,
Vector BioLabs ,
Primers from
OriGene ,
SABiosciences , and/or
QIAGEN
)About This Section REFSEQ mRNAs for AFAP1 gene (3 alternative transcripts): NM_001134647.1 NM_198595.2 NM_021638.4 Unigene Cluster for AFAP1:
Actin filament associated protein 1 Hs.529369 [show with all ESTs ] Unigene Representative Sequence: NM_001134647 8 Ensembl transcripts including schematic representations, and UCSC links where relevant : ENST00000360265 ENST00000505447 ENST00000513842 ENST00000382543 ENST00000508415 ENST00000513856 ENST00000420658 (uc011bwk.1 ) ENST00000358461 (uc003gkg.1 )Clone Products: OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human , mouse , rat for AFAP1 (see all 5 ) OriGene untagged cDNA clones in CMV expression vector in human , mouse , rat for AFAP1 (see all 3 )OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling GenScript: all cDNA clones in your preferred vector (see all 2 ): AFAP1 (NM_198595 ) DNA2.0 Custom Codon Optimized Gene
Synthesis Service for AFAP1 Vector BioLabs ready-to-use adenovirus/AAV for human , mouse , rat AFAP1
Additional cDNA sequence: AB209676.1 AF188700.1 AK127962.1 AK290807.1 AK297631.1 BC015900.1 BC032777.1 D25248.1 XR_112616.1
6 DOTS entries : DT.97822158 DT.215914
DT.101956502 DT.121232595 DT.92067800 DT.100829322 24/126 AceView cDNA sequences (see all 126 ):
CR606819 BF036843 AA292097 F02531 AA322072 NM_021638 BC032777 D57870 AI913295 AI188460 F08751 AI085991 R43661 F06246 BU616014 BU186955 BU164761 BX950996 AI468446 AI291099 AW151921 CB217097 NM_198595 BU686680 GeneLoc Exon Structure 5/12 Alternative Splicing Database (ASD) splice patterns (SP) for AFAP1 (see all 12 ) About this scheme ExUns: 1a · 1b ^ 2a · 2b ^ 3a · 3b ^ 4 ^ 5 ^ 6a · 6b ^ 7 ^ 8a · 8b · 8c · 8d ^ 9a · 9b · 9c · 9d ^ 10 ^ 11 ^ 12 ^ 13 ^ 14 ^ 15 ^ 16 ^ SP1 :     -   -         -       -         -                         SP2 :               -       -                                 SP3 :                     -         -                         SP4 :     -   -     -   -   -       -         -                         SP5 :                                                 -    
ExUns: 17 ^ 18 ^ 19 ^ 20 ^ 21 ^ 22 ^ 23a · 23b SP1 :                 SP2 :                 SP3 :                 SP4 :                 SP5 :                
ECgene alternative splicing isoforms for AFAP1
Jump to Section...
Aliases
Databases
Disorders / Diseases
Domains / Families
Drugs / Compounds
Expression
Function
Genomic Views
Intellectual Property
Orthologs
Paralogs
Pathways / Interactions
Products
Proteins
Publications
Search Box
Summaries
Transcripts
Variants
TOP
BOTTOM
Expression for AFAP1 gene
(RNA expression data according to
H-InvDB ,
NONCODE ,
miRBase , and
RNAdb ,
Expression images according to data from
BioGPS ,
Illumina Human BodyMap , and
CGAP
SAGE ,
Sets of similar genes according to GeneDecks ,
in vivo and in vitro expression data from LifeMap Discovery™ ,
plus additional links to
Genevestigator , and/or
SOURCE , and/or
BioGPS , and/or
UniProtKB ,
PCR Arrays from
SABiosciences ,
Primers from
OriGene ,
SABiosciences , and/or
QIAGEN ,
In Situ Hybridization Assays from Advanced Cell Diagnostics )
About This Section AFAP1 expression in normal human tissues (normalized intensities) See probesets specificity/sensitivity at GeneAnnot About this image BioGPS CGAP TAG: GTGATACGTT
About this image AFAP1 expression in embryonic tissues and stem cells Expression by the Database of Embryonic development, Stem cell research, and
Regenerative medicine About this table Stem Cell Differentiation: 1 LifeMap Cell Name Category Late limb mesenchymal cells (LLM cells) (Primary Cell)Bone, Cartilage, Limb Expression: Positive Negative
Selective markerExperimental details:
Curated
Microarrays
In-situ hybridization
See AFAP1 Protein Expression from SPIRE MOPED and PaxDB Genevestigator expression for AFAP1 SOURCE GeneReport for Unigene cluster: Hs.529369 UniProtKB/Swiss-Prot: AFAP1_HUMAN, Q8N556 Tissue specificity : Low expression in normal breast epithelial cell line MCF-10A and in tumorigenic breast cancer celllines MCF-7, T-47D and ZR-75-1. Highly expressed in the invasive breast cancer cell lines MDA-MB-231 and MDA-MB-435. Overexpressed in prostate carcinoma SABiosciences Custom PCR Arrays for AFAP1 Primer Products: OriGene genome-wide validated SYBR primer pairs in human , mouse , rat for AFAP1Browse OriGene validated miRNA SYBR primer pairs SABiosciences RT2 qPCR Primer Assay in human , mouse / rat AFAP1 QIAGEN QuantiTect SYBR Green Assays in human , mouse , rat AFAP1 QIAGEN QuantiFast Probe-based Assays in human , mouse , rat AFAP1 In Situ Assay Products: Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for AFAP1
Jump to Section...
Aliases
Databases
Disorders / Diseases
Domains / Families
Drugs / Compounds
Expression
Function
Genomic Views
Intellectual Property
Orthologs
Paralogs
Pathways / Interactions
Products
Proteins
Publications
Search Box
Summaries
Transcripts
Variants
TOP
BOTTOM
Orthologsfor AFAP1 gene
(Orthologs according to
1,2 HomoloGene (2 older version, for species not in 1 newer version),
3 euGenes ,
4 SGD
,
5 MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase ,
and/or
6 Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam )
About This Section
This gene was present in the common ancestor of chordates.
Orthologs for AFAP1 gene from 3/9 species (see all 9 ) About this table
Organism
Taxonomic classification
Gene
Description
Human Similarity
Orthology Type
Details
chicken (Gallus gallus)
Aves
AFAP11
actin filament associated protein 1
79.4(n) 87.39(a)
 
374034 NM_204205.1 NP_989536.1
lizard (Anolis carolinensis)
Reptilia
AFAP16
--
82(a)
1 ↔ 1
4(79727096-79779002)
zebrafish (Danio rerio)
Actinopterygii
LOC5683561
actin filament-associated protein 1-like
68.21(n) 71.05(a)
 
568356 XM_691682.3 XP_696774.3
ENSEMBL Gene Tree for AFAP1 (if available)TreeFam Gene Tree for AFAP1 (if available)
Jump to Section...
Aliases
Databases
Disorders / Diseases
Domains / Families
Drugs / Compounds
Expression
Function
Genomic Views
Intellectual Property
Orthologs
Paralogs
Pathways / Interactions
Products
Proteins
Publications
Search Box
Summaries
Transcripts
Variants
TOP
BOTTOM
Paralogsfor AFAP1 gene (Paralogs according to
1 HomoloGene , 2 Ensembl , and 3 SIMAP , Pseudogenes according to 4 Pseudogene.org Build 68)About This Section Paralogs for AFAP1 gene AFAP1L2 2 AFAP1L1 2 2 SIMAP similar genes for AFAP1 using alignment to 1 protein entry: AFAP1_HUMAN :AFAP1L1 AFAP1L2
AFAP1 for paralogs About GeneDecksing
Jump to Section...
Aliases
Databases
Disorders / Diseases
Domains / Families
Drugs / Compounds
Expression
Function
Genomic Views
Intellectual Property
Orthologs
Paralogs
Pathways / Interactions
Products
Proteins
Publications
Search Box
Summaries
Transcripts
Variants
TOP
BOTTOM
Genomic Variantsfor AFAP1 gene (SNPs/Variants according to the
1 NCBI SNP Database ,
2 Ensembl ,
3 PupaSUITE ,
UniProtKB , and
DNA2.0 ,
Linkage Disequilibrium by HapMap ,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants , Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB) , Blood group antigen gene mutations by BGMUT ,
Resequencing Primers from QIAGEN ,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences )
About This Section Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions) Database of Genomic Variants (DGV): 15 variations for AFAP1 10 CNVs : 47968 91917 91916 80172 80175 91915 80173 63741 91918 80174 5 Indels : 98621 12401 46696 68661 60455 SABiosciences Cancer Mutation PCR Assays
QIAGEN SeqTarget long-range PCR primers in human , mouse , rat for resequencing AFAP1
Jump to Section...
Aliases
Databases
Disorders / Diseases
Domains / Families
Drugs / Compounds
Expression
Function
Genomic Views
Intellectual Property
Orthologs
Paralogs
Pathways / Interactions
Products
Proteins
Publications
Search Box
Summaries
Transcripts
Variants
TOP
BOTTOM
Disorders
/ Diseasesfor AFAP1 gene
(in which this Gene is Involved, According to MalaCards ,
OMIM, UniProtKB ,
the University of Copenhagen DISEASES
database ,
Genatlas , GeneTests ,
GAD ,
HuGE Navigator ,
and/or TGDB .)
About This Section
AFAP1 for disorders About GeneDecksing
OMIM gene information: 608252
OMIM disorders : --9 diseases for AFAP1 : About MalaCards familial adenomatous polyposis polyposis prostate adenocarcinoma prostatitis prostate carcinoma adenocarcinoma prostate cancer breast cancer carcinoma Export disorders for AFAP1 gene to outside databases
Jump to Section...
Aliases
Databases
Disorders / Diseases
Domains / Families
Drugs / Compounds
Expression
Function
Genomic Views
Intellectual Property
Orthologs
Paralogs
Pathways / Interactions
Products
Proteins
Publications
Search Box
Summaries
Transcripts
Variants
TOP
BOTTOM
Publicationsfor AFAP1 gene (in
PubMed .
Associations of this gene to articles via
1 Entrez Gene ,
2 UniProtKB/Swiss-Prot ,
3 HGNC ,
4 GAD ,
5 PharmGKB ,
6 HMDB ,
7 DrugBank ,
8 UniProtKB/TrEMBL ,
9 Novoseek , and/or
10 fRNAdb )
About This Section PubMed articles for AFAP1 gene, integrated from 9 sources (see all 44 ): (articles sorted by number of sources associating them with AFAP1) Utopia : connect your pdf to the dynamic world of online information
AFAP-110 is required for actin stress fiber formation and cell adhesion in MDA-MB-231 breast cancer cells. (PubMed id 17520695) 1 , 2 , 9 Dorfleutner A.... Flynn D.C. (2007) The intrinsic ability of AFAP-110 to alter actin filament integrity is linked with its ability to also activate cellular tyrosine kinases. (PubMed id 11641786) 1 , 3, 9 Baisden J.M....Flynn D.C. (2001) The actin filament-associated protein AFAP-110 is an adaptor protein that modulates changes in actin filament integrity. (PubMed id 11607843) 1 , 3, 9 Baisden J.M....Flynn D.C. (2001) Analysis of the role of the leucine zipper motif in regulating the ability of AFAP-110 to alter actin filament integrity. (PubMed id 14755689) 1 , 3, 9 Qian Y....Flynn D.C. (2004) AFAP-110 is overexpressed in prostate cancer and contributes to tumorigenic growth by regulating focal contacts. (PubMed id 17885682) 2 , 9 Zhang J.... Gallick G.E. (2007) Conversion of mechanical force into biochemical signaling. (PubMed id 15485829) 2 , 9 Han B....Liu M. (2004) System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation. (PubMed id 21406692) 2 Rigbolt K.T....Blagoev B. (2011) Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis. (PubMed id 20068231) 2 Olsen J.V....Mann M. (2010) A quantitative atlas of mitotic phosphorylation. (PubMed id 18669648) 2 Dephoure N.... Gygi S.P. (2008) Toward a confocal subcellular atlas of the human proteome. (PubMed id 18029348) 1 Barbe L....Andersson-Svahn H. (2008)
Jump to Section...
Aliases
Databases
Disorders / Diseases
Domains / Families
Drugs / Compounds
Expression
Function
Genomic Views
Intellectual Property
Orthologs
Paralogs
Pathways / Interactions
Products
Proteins
Publications
Search Box
Summaries
Transcripts
Variants
TOP
BOTTOM
External Searches for AFAP1 gene
(in PubMed ,
OMIM , and NCBI Bookshelf ) About This Section
Jump to Section...
Aliases
Databases
Disorders / Diseases
Domains / Families
Drugs / Compounds
Expression
Function
Genomic Views
Intellectual Property
Orthologs
Paralogs
Pathways / Interactions
Products
Proteins
Publications
Search Box
Summaries
Transcripts
Variants
TOP
BOTTOM
Genome Databases showing AFAP1 gene
(According to
Entrez Gene ,
HGNC ,
AceView ,
euGenes ,
Ensembl ,
miRBase ,
ECgene ,
Kegg ,
and/or
H-InvDB )
About This Section
Jump to Section...
Aliases
Databases
Disorders / Diseases
Domains / Families
Drugs / Compounds
Expression
Function
Genomic Views
Intellectual Property
Orthologs
Paralogs
Pathways / Interactions
Products
Proteins
Publications
Search Box
Summaries
Transcripts
Variants
TOP
BOTTOM
Other Databases showing AFAP1 gene
(According to HUGE )
About This Section --
Jump to Section...
Aliases
Databases
Disorders / Diseases
Domains / Families
Drugs / Compounds
Expression
Function
Genomic Views
Intellectual Property
Orthologs
Paralogs
Pathways / Interactions
Products
Proteins
Publications
Search Box
Summaries
Transcripts
Variants
TOP
BOTTOM
Specialized Databases showing AFAP1 gene (According to PharmGKB ,
ATLAS , HORDE , IMGT , LEIDEN , UniProtKB/Swiss-Prot , and/or UniProtKB/TrEMBL ,Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot )About This Section
Name Description
PharmGKB entry for AFAP1 Pharmacogenomics, SNPs, Pathways
Jump to Section...
Aliases
Databases
Disorders / Diseases
Domains / Families
Drugs / Compounds
Expression
Function
Genomic Views
Intellectual Property
Orthologs
Paralogs
Pathways / Interactions
Products
Proteins
Publications
Search Box
Summaries
Transcripts
Variants
TOP
BOTTOM
About This Section Patent Information for AFAP1 gene: Search GeneIP for patents involving AFAP1 GeneCards and IP: Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
Jump to Section...
Aliases
Databases
Disorders / Diseases
Domains / Families
Drugs / Compounds
Expression
Function
Genomic Views
Intellectual Property
Orthologs
Paralogs
Pathways / Interactions
Products
Proteins
Publications
Search Box
Summaries
Transcripts
Variants
TOP
BOTTOM
Productsfor AFAP1 gene (Antibodies, recombinant proteins, and assays from EMD Millipore , R&D Systems , OriGene , QIAGEN , GenScript , Cell Signaling Technology , SABiosciences , Novus Biologicals , Sino Biological , Enzo Life Sciences , Abcam , ProSpec , Uscn , Thermo Fisher Scientific , Gene Editing from DNA2.0 , Clones from EMD Millipore , OriGene , GenScript , Sino Biological , DNA2.0 , SwitchGear Genomics , Vector BioLabs , Cell lines from GenScript and LifeMap BioReagents , PCR Arrays from SABiosciences , Drugs and/or compounds from EMD Millipore , Tocris Bioscience , and/or
Enzo Life Sciences ), In Situ Hybridization Assays from Advanced Cell Diagnostics About This Section
Browse OriGene Antibodies OriGene shRNA RFP for AFAP1 OriGene 29mer shRNA kits in GFP-retroviral vector in human , mouse , rat for AFAP1 OriGene genome-wide validated SYBR primer pairs in human , mouse , rat for AFAP1 OriGene Protein Over-expression Lysate for AFAP1 Browse OriGene Fluorogenic Cell Assay Kits OriGene siRNA for AFAP1 OriGene 3'-UTR Clone for AFAP1 OriGene untagged cDNA clones in CMV expression vector in human , mouse , rat for AFAP1 OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human , mouse , rat for AFAP1 Browse OriGene GFP tagged cDNA clones in CMV expression vector Browse OriGene MicroRNA Expression Plasmids Browse OriGene basic RS shRNAs Browse OriGene validated miRNA SYBR primer pairs Browse OriGene full length recombinant human proteins expressed in human HEK293 cells OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling OriGene Custom Antibody Services for AFAP1 OriGene Custom Protein Services for AFAP1 OriGene Custom Immunoassay Development
QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat AFAP1 QIAGEN SeqTarget long-range PCR primers in human , mouse , rat for resequencing AFAP1 QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat AFAP1 QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human , mouse , rat AFAP1 QIAGEN QuantiFast Probe-based Assays in human , mouse , rat AFAP1 QIAGEN QuantiTect SYBR Green Assays in human , mouse , rat AFAP1
Search Tocris compounds for AFAP1
AFAP1 Proteins, Antibodies, CLIAs, and ELISAs
Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for AFAP1
Search ThermoFisher Antibodies for AFAP1
Vector BioLabs ready-to-use adenovirus/AAV for human , mouse , rat AFAP1
Jump to Section...
Aliases for AFAP1
Databases for AFAP1
Disorders / Diseases for AFAP1
Domains / Families for AFAP1
Drugs / Compounds for AFAP1
Expression for AFAP1
Function for AFAP1
Genomic Views for AFAP1
Intellectual Property for AFAP1
Orthologs for AFAP1
Paralogs for AFAP1
Pathways / Interactions for AFAP1
Products for AFAP1
Proteins for AFAP1
Publications for AFAP1
Search Box for AFAP1
Summaries for AFAP1
Transcripts for AFAP1
Variants for AFAP1
TOP
BOTTOM