Aliases for AES Gene
External Ids for AES Gene
Previous GeneCards Identifiers for AES Gene
The protein encoded by this gene is similar in sequence to the amino terminus of Drosophila enhancer of split groucho, a protein involved in neurogenesis during embryonic development. The encoded protein, which belongs to the groucho/TLE family of proteins, can function as a homooligomer or as a heteroologimer with other family members to dominantly repress the expression of other family member genes. Three transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]
GeneCards Summary for AES Gene
AES (Amino-Terminal Enhancer Of Split) is a Protein Coding gene. Diseases associated with AES include autoimmune polyendocrine syndrome type 2. Among its related pathways are Signaling by GPCR and Presenilin action in Notch and Wnt signaling. GO annotations related to this gene include transcription corepressor activity. An important paralog of this gene is TLE2.
UniProtKB/Swiss-Prot for AES Gene
Transcriptional corepressor. Acts as dominant repressor towards other family members. Inhibits NF-kappa-B-regulated gene expression. May be required for the initiation and maintenance of the differentiated state. Essential for the transcriptional repressor activity of SIX3 during retina and lens development.