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AES Gene

protein-coding GIFtS: 59

GC19M003003

amino-terminal enhancer of split
Symbol approved by the HUGO Gene Nomenclature Committee (HGNC) database

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc , and/or ⁷Ensembl, ⁸miRBase)
About This Section

Aliases
AES-1 ^²
AES-2 ^²
ESP1 ^²
GRG ^², ³
GRG5 ^¹, ²
TLE5 ^¹, ²

Descriptions
Amino enhancer of split ^³
GRG protein ^³
Gp130-associated protein GAM ^³
Protein ESP1 ^³
amino-terminal enhancer of split ^²

External Ids
HGNC: 307¹
Entrez Gene: 166²
UniProtKB: Q08117³
Ensembl: ENSG00000104964⁷

Search outside databases for aliases for AES gene

Previous GC identifers: GC19M003145 GC19M002992

(According to Entrez Gene, Wikipedia's Gene Wiki,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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EntrezGene summary for AES:

The protein encoded by this gene is similar in sequence to the amino terminus of Drosophila

enhancer of split groucho, a protein involved in neurogenesis during embryonic development. The

encoded protein, which belongs to the groucho/TLE family of proteins, can function as a

homooligomer or as a heteroologimer with other family members to dominantly repress the expression

of other family member genes. Three transcript variants encoding different isoforms have been

found for this gene. [provided by RefSeq]

UniProtKB/Swiss-Prot: AES_HUMAN, Q08117

Function: Acts as dominant repressor towards other family members. Inhibits NF-kappa-B-regulated

gene expression. May be required for the initiation and maintenance of the differentiated state

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 36),
and/or miRBase,
Genomic Views according to UCSC and Ensembl, Transcription factor binding sites according to SABiosciences)
About This Section

Genomic View:

UCSC Golden Path with GeneCards custom track

Transcription factor binding sites upstream to the AES gene

Entrez Gene cytogenetic band: 19p13.3 Ensembl cytogenetic band: 19p13.3 HGNC cytogenetic band: 19p13.3

AES Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)

GeneLoc gene densities for chromosome 19 GeneLoc Exon Structure

GeneLoc location for GC19M003003: (about GC identifiers)

Start:	3,003,908 bp from pter
End:	3,013,964 bp from pter
Size:	10,057 bases
Orientation:	minus strand

RefSeq DNA sequence:

NC_000019.8 NT_011255.14

(According to ¹UniProtKB, and/or Ensembl, Phosphorylation sites according to ²Phosphosite, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Enzo Life Sciences, Abnova, OriGene and/or, Abcam,
Biochemical Assays by Invitrogen, Millipore, R&D Systems, Cell Signaling Technology, and/or Enzo Life Sciences, Ontologies according to Gene Ontology Consortium 01 Apr 2009 and Entrez Gene, Antibodies by Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Cell Signaling Technology, Abcam, Abnova, and/or Novus Biologicals)
About This Section

UniProtKB/Swiss-Prot: AES_HUMAN, Q08117 (See protein sequence)

Recommended Name: Amino-terminal enhancer of split

Size: 197 amino acids; 21970 Da

Subunit: Homooligomer and heterooligomer with other family members. Binds TCF7 (By similarity).

Binds the NF-kappa-B subunit RELA. Interacts with PHF12

Subcellular location: Nucleus (By similarity)

Secondary accessions: Q12808 Q96TG9 Q9UDY9

Alternative splicing: 2 isoforms: Q08117-1 Q08117-2

Post-translational modifications:

View phosphorylation sites using PhosphoSite²

REFSEQ proteins (3 alternative transcripts):

NP_001121.2 NP_945320.1 NP_945321.1

ENSEMBL proteins:

ENSP00000221561 ENSP00000317537

Human Recombinant Proteins

	Browse Drug Discovery Central at Invitrogen for human recombinant proteins
	Browse Purified and Recombinant Proteins at Millipore
	Browse Human Recombinant Proteins at Sigma-Aldrich
	Browse R&D Systems for human recombinant proteins
	Browse recombinant and purified proteins available from Enzo Life Sciences
	Recombinant Proteins from Abcam (GRG (Groucho homologue))
	Human Recombinant Proteins from Abnova (AES)

Browse Origene for full length recombinant human proteins expressed in human HEK293 cells

1 Gene Ontology (GO) cellular component term (links to tree view):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005634	nucleus	IEA	--

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Antibodies for AES:

	Browse Antibodies Central at Invitrogen
	Browse Millipore's Extensive Line of Mono- and Polyclonal Antibodies
	Sigma-Aldrich Antibodies for AES
	Browse R&D Systems for Antibodies
	Antibodies from Abcam (GRG (Groucho homologue)), each with their Abpromise^SM
	Monoclonal and Polyclonal Antibodies from Abnova (AES)
	Novus Biologicals Antibodies for AES

Assays for AES:

	Browse Invitrogen for biochemical assays
	Browse Kits and Assays available from Millipore
	Browse R&D Systems for biochemical assays
	Browse biochemical assays available from Enzo Life Sciences

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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Graphical View of Domain Structure for InterPro Entry Q08117

ProtoNet protein and cluster: Q08117

UniProtKB/Swiss-Prot: AES_HUMAN, Q08117

Domain: Lacks the C-terminal WD repeats

Similarity: Belongs to the WD repeat Groucho/TLE family

(According to MGI Jun 06 2009, UniProtKB, IUBMB,and/or Genatlas,
shRNA from OriGene, Sigma-Aldrich, RNAi from Sigma-Aldrich,
RNAi Products, Clones, and Q-PCR Products from Invitrogen, Millipore, OriGene, and/or Abnova, siRNAs from Applied Biosystems, SYBR primers from OriGene, Cell-based Assays from Millipore, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
About This Section

Inhib. RNA:		Browse Invitrogen for RNAi
		Browse for Gene Knock-down Tools from Millipore
		Abnova Chimera RNAi Products for Gene knock-down (AES)

OriGene 29mer shRNA kit in GFP-retroviral vectors (see all 3): NM_001130

Applied Biosystems Silencer® siRNAs for AES

Sigma-Aldrich siRNA for AES

Sigma-Aldrich shRNA for AES

Explore Sigma-Aldrich super-pooled esiRNAs

Clones:		Invitrogen Clones for AES
		Browse Clones for the Expression of Recombinant Proteins Available from Millipore

OriGene GFP tagged cDNA clones in CMV expression vector (see all 3): NM_001130
Myc/DDK tagged cDNA clones in CMV expression vector (see all 3): NM_001130
untagged cDNA clones in CMV expression vector (see all 3): NM_001130

Primers:

Browse Quantitative PCR Central at Invitrogen for Q-PCR LUX™ Primers

OriGene genome-wide validated SYBR primer pairs: NM_198969

UniProtKB/Swiss-Prot: AES_HUMAN, Q08117

Function: Acts as dominant repressor towards other family members. Inhibits NF-kappa-B-regulated

gene expression. May be required for the initiation and maintenance of the differentiated state

Genatlas biochemistry entry for AES:

amino-terminal enhancer of split,homologous to Drosophila ESG enhancer of split Groucho,mainly

expressed in muscle,heart,brain

9 MGI mutant phenotypes (inferred from 1 allele) (MGI details for Aes):

behavior/neurological	craniofacial	endocrine/exocrine gland	growth/size	life span-post-weaning/aging
limbs/digits/tail	nervous system	reproductive system	skeleton

3 Gene Ontology (GO) molecular function terms (links to tree view):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0003714	transcription corepressor activity	IEA	--
GO:0005515	protein binding	IPI	11390640
GO:0030528	transcription regulator activity	IEA	--

About this table

(Pathways according to Invitrogen (maps by GeneGo), Millipore, Cell Signaling Technology, Sigma-Aldrich, KEGG and/or UniProtKB,
Sets of similar genes according to GeneDecks, Proteins Network according to SABiosciences, Interactions according to ¹UniProtKB, ²MINT, and/or ³STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
About This Section

Gene Network Central^TM Interacting Genes and Proteins Network for AES

5/41 Interacting proteins for AES (ENSP00000221561³ Q08117^{1, 2}) via UniProtKB, MINT, and/or STRING (see all 41 )

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
TLE1	Q04724¹	STRING (score=.949) EBI-717810, EBI-711424
HNRNPAB	Q99729¹	EBI-717810, EBI-1044873
STYXL1	Q9Y6J8¹	EBI-717810, EBI-1044511
TLE3	Q04726¹	EBI-717810, EBI-1052057
ATN1	P54259²	MINT-2856829

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5/7 Gene Ontology (GO) biological process terms (links to tree view) (see all 7 ):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0001501	skeletal system development	IEA	--
GO:0006357	regulation of transcription from RNA polymerase II promoter	IEA	--
GO:0007275	multicellular organismal development	TAS	8365415
GO:0009887	organ morphogenesis	TAS	9809752
GO:0016055	Wnt receptor signaling pathway	IEA	--

About this table

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, Sigma-Aldrich, Tocris Bioscience, and/or Novoseek and Drugs according to Enzo Life Sciences and/or PharmGKB)
About This Section

Browse drugs & compounds from Enzo Life Sciences

Browse Small Molecules at Sigma-Aldrich

Browse Tocris compounds for AES

(GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 219 Homo sapiens; Jun 2 2009) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView,
non coding RNAs according to RNAdb,
ESTs according to GeneTide,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from Invitrogen, Millipore, and/or Abnova,
siRNAs from Applied Biosystems, Sigma-Aldrich,
shRNA from Sigma-Aldrich, OriGene,
Tagged/untagged cDNA clones from OriGene,
Expression Assays from Applied Biosystems)
About This Section

Inhib. RNA:		Browse Invitrogen for RNAi
		Browse for Gene Knock-down Tools from Millipore
		Abnova Chimera RNAi Products for Gene knock-down (AES)

OriGene 29mer shRNA kit in GFP-retroviral vectors (see all 3): NM_001130

Sigma-Aldrich siRNA for AES

Sigma-Aldrich shRNA for AES

Explore Sigma-Aldrich super-pooled esiRNAs

Applied Biosystems Silencer® siRNAs:

NM_001130 NM_198969 NM_198970

REFSEQ mRNAs for AES gene (3 alternative transcripts):

NM_001130.5 NM_198969.1 NM_198970.1

Applied Biosystems TaqMan ® Gene Expression Assays:

NM_001130 NM_198969 NM_198970

               OriGene GFP tagged cDNA clones in CMV expression vector (see all 3): NM_001130
                                 Myc/DDK tagged cDNA clones in CMV expression vector (see all 3): NM_001130
                                 untagged cDNA clones in CMV expression vector (see all 3): NM_001130

Additional cDNA sequence:

AF072902.1 AF269289.1 AK094591.1 AK095154.1 AK314713.1 BC113735.1 BC113737.1 CR591354.1

CR591743.1 CR594247.1 CR594475.1 CR594586.1 CR595893.1 CR596634.1 CR598322.1 CR599584.1

CR605502.1 CR606153.1 CR608829.1 CR609469.1 CR613028.1 CR616198.1 CR617074.1 CR622685.1

CR625320.1 U04241.1 X73357.1 X73358.1

24/42 DOTS entries (see all 42 ):

DT.95176523 DT.100045190 DT.100858154 DT.91821772 DT.100808380 DT.121500399 DT.87017800 DT.121500449

DT.92460433 DT.100858157 DT.100858140 DT.121500435 DT.97863603 DT.100858142 DT.100858148 DT.121500452

DT.91900598 DT.92375835 DT.100858151 DT.95277120 DT.100045184 DT.100858139 DT.95277118 DT.97858075

24/995 AceView cDNA sequences (see all 995 ):

AI200348 CR617074 AA485742 NM_198969 AA349921 AI679427 AA911178 AI749936

BM789966 BM693746 CB156044 BF477434 AA946689 BM686583 AI383154 AA878074

BM824413 CD675600 BQ430553 BG114708 BF002306 CR616198 BQ961816 CR594475

highest scoring ESTs for AES:

AI969192 AK094591 AL534525 AL556422 BE512945 BE615093 BE615671 BE615790 BE615936 BF312908

Unigene Cluster for AES:

Amino-terminal enhancer of split

Hs.515053 [show with all ESTs]

Unigene Representative Sequence: AK095154

GeneLoc Exon Structure

5/12 Alternative Splicing Database (ASD) splice patterns (SP) for AES (see all 12 )

ExUns:	1a	·	1b	·	1c	·	1d	^	2a	·	2b	^	3a	·	3b	·	3c	·	3d	^	4a	·	4b	^	5a	·	5b	^	6	^	7a	·	7b	·	7c	^	8	^	9a	·	9b	·	9c
SP1:									-		-		-		-				-				-		-		-				-				-
SP2:							-		-		-		-		-				-				-		-		-				-				-
SP3:													-		-				-				-		-		-				-				-
SP4:													-		-				-						-		-				-				-
SP5:									-		-		-		-				-				-		-		-				-				-

About this scheme

ECgene alternative splicing isoforms for AES

2 Ensembl transcripts including schematic representations:

ENST00000221561 ENST00000327141

(Experimental results according to ¹GeneNote and GNF BioGPS,
probe sets-to-genes annotations according to ²GeneAnnot , ³GeneTide , Sets of similar genes according to GeneDecks, Electronic Northern calculations according to data from UniGene (Build 219 Homo sapiens), SAGE tags according to CGAP, plus additional links to SOURCE, and/or GNF BioGPS, and/or EXPOLDB, and/or UniProtKB,
Expression Assays from Applied Biosystems )
About This Section

AES expression in normal and diseased human tissues

Applied Biosystems TaqMan ® Gene Expression Assays for AES

¹ / ² / ³

5 probe-sets matching AES gene

Affymetrix probe-set	Array	# genes	Sensitivity	Specificity	Correlation	Length	Gb_Accession	Consensus	Uniqueness	Score	Rank
Affymetrix probe-set	Array	GeneAnnot data			GeneNote data		GeneTide data
41338_at²^{, 3}	U95-A	1	1.00	1.00	0.96	1.01	AI969192	0.80	1.00	0.91	1
76050_s_at²^{, 3}	U95-E	1	1.00	1.00	0.95	1.17	R79768	0.60	1.00	0.82	1
41337_at²^{, 3}	U95-A	1	1.00	1.00	0.85	0.82	U04241	0.80	1.00	0.91	1
217729_s_at²^{, 3}	U133-A	1	1.00	1.00	--	--	NM_001130	0.60	1.00	0.82	1
217729_s_at²	U133Plus2	1	1.00	1.00	--	--	--	--	--	--	--

About this table

Data from

(Publications) and GNF BioGPS
About these images
About these images

CGAP SAGE TAG: CACGCAATGC

SOURCE GeneReport for Unigene cluster: Hs.515053
Expression variation in blood from EXPOLDB for AES
UniProtKB/Swiss-Prot: AES_HUMAN, Q08117
Tissue specificity: Found predominantly in muscle, heart and Placenta. In fetal tissues, abundantly
expressed in the heart, lung, kidney, brain and liver

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD and/or ⁵MGI Jun 06 2009, with possible further links to Flybase and/or WormBase, Gene Trees according to Ensembl)
About This Section

Orthologs for AES gene from 5/8 species (see all 8 )

Organism	Gene	Locus	Description	Human Similarity	NCBI accessions
dog (Canis familiaris)	AES¹	--	amino-terminal enhancer of split	83.62(n) 85.04(a)	485064 XM_542182.2 XP_542182.2
chimpanzee (Pan troglodytes)	AES¹	--	amino-terminal enhancer of split	98.74(n) 98.39(a)	744806 XM_001153657.1 XP_001153657.1
cow (Bos taurus)	AES¹	--	amino-terminal enhancer of split	92.56(n) 99.17(a)	505375 XM_581653.3 XP_581653.3
rat (Rattus norvegicus)	Aes¹	--	amino-terminal enhancer of split	86.7(n) 99.47(a)	29466 NM_019220.1 NP_062093.1
mouse (Mus musculus)	Aes^{1, 5}	10 (43.00 cM)⁵	amino-terminal enhancer of split^{1, 5}	86.35(n)¹ 99.47(a)¹	14797¹ NM_010347.3¹ NP_034477.1¹ AK019397⁵ AK131845⁵ (see all 17)

About this table Species with no ortholog for AES

ENSEMBL Gene Tree for AES

(Paralogs according to ¹HomoloGene
and ²Ensembl, Pseudogenes according to ³Pseudogene.org)
About This Section

Paralogs for AES gene

TLE6² TLE2²

(According to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, and UniProtKB, Linkage Disequilibrium by HapMap, Genotyping Reagents from Applied Biosystems)
About This Section

10/84 NCBI SNPs in AES are shown (see all 84 )
(Click for Applied Biosystems TaqMan ® Genotyping Assay) (see all 49)

AB	SNP ID	Valid	Chr 19 pos	Sequence	Recs	AA Chg	Type	More	Recs	Allele freq	Pop	Total sample	More
AB	Genomic Data				Transcription Data				Allele Frequencies
				--	--	--		--	--				--
	rs7938^1,2	A,C,F,H	3004574(-)	`CTGACA/GTGTGA`	3	--	ut3¹ ese³		17		MN EA NA EU WA	3092
	rs367825^1,2	A,C,F,H	3014409(+)	`agattC/Tctaat`	3	--	ng3¹		4		EU EA WA	420
	rs415945^1,2	A,C,H	3004326(+)	`GTGAGT/GGGGGC`	3	--	ut3¹ ese³		4		MN EU EA	482
	rs9294^1,2	C,F,H	3004658(-)	`TTGCAG/AGCCAC`	3	--	ut3¹		8		MN NA EU EA WA	586
	rs425485^1,2	C,F	3004802(+)	`CTCCCT/CGTCCC`	3	--	ut3¹ ese³		2		EA MN	1682
	rs3746076^1,2	C,F	3004722(-)	`AGCTCG/AGGATT`	3	--	ut3¹ ese³		1		EA	1502
--	rs451086^1,2	A,C	3003630(+)	`gcctcC/Ttaagt`	3	--	ng5¹		0	--	--	--	--
	rs1062635^1,2	A	3004066(-)	`AAAAAA/GACAAA`	3	--	ut3¹		0	--	--	--	--
--	rs4807393^1,2	A	3015066(+)	`GAGACA/GGGTTT`	3	--	ng3¹		0	--	--	--	--
	rs1042548^1,2	A	3004315(-)	`CACCTC/TTGCTA`	3	--	ut3¹ ese³		1		MN	184

About this table

HapMap Linkage Disequilibrium images for AES (up to first 250kb)

(in which this Gene is Involved, According to OMIM, UniProtKB, PharmGKB, Genatlas, GeneTests, Blood group antigen gene mutations by BGMUT, HGMD, GAD, HuGE Navigator, BCGD, and/or TGDB.)
About This Section

OMIM: 600188

1 PharmGKB disease relationship for AES gene

Disease	PharmGKB Relations	PubMed IDs for articles supporting these relationships
Leukemia, Lymphocytic, Acute, L1	FA GN	12086872

About this table

(Possibly Related Articles in Doctor's Guide)
About This Section

(in PubMed. Associations of this gene to articles via ¹Novoseek, ²HGNC, ³Entrez Gene, ⁴UniProtKB/Swiss-Prot, ⁵UniProtKB/TrEMBL, ⁶GAD, and/or ⁷PharmGKB)
About This Section

10/27 PubMed articles for AES gene (see all 27 ):

Molecular cloning and expression of mouse and human cDNA encoding AES and ESG proteins with strong similarity to Drosophila enhancer of split groucho protein. (PubMed id 8365415)^{1, 2, 3, 4} Miyasaka H.... Li S.S.-L. (1993)
The DNA sequence and biology of human chromosome 19. (PubMed id 15057824)^{3, 4} Grimwood J.... Lucas S.M. (2004)
Pf1, a novel PHD zinc finger protein that links the TLE corepressor to the mSin3A-histone deacetylase complex. (PubMed id 11390640)^{3, 4} Yochum G.S. and Ayer D.E. (2001)
Inhibition of nuclear factor-kappaB-mediated transcription by association with the amino-terminal enhancer of split, a Groucho- related protein lacking WD40 repeats. (PubMed id 10660609)^{3, 4} Tetsuka T.... Okamoto T. (2000)
Transducin-like enhancer of split proteins, the human homologs of Drosophila groucho, interact with hepatic nuclear factor 3beta. (PubMed id 10748198)^{3, 4} Wang J.-C....Granner D.K. (2000)
Genomic organization and chromosome localization to band 19p13.3 of the human AES gene: gene product exhibits strong similarity to the N- terminal domain of Drosophila enhancer of split Groucho protein. (PubMed id 9809752)^{3, 4} Hou E.W. and Li S.S.-L. (1998)
All Tcf HMG box transcription factors interact with Groucho-related co-repressors. (PubMed id 11266540)^{1, 3} Brantjes H.... Clevers H. (2001)
Histone deacetylase-related protein inhibits AES-mediated neuronal cell death by direct interaction. (PubMed id 18438919)³ Zhang X....D'Mello S.R. (2008)
Large-scale mapping of human protein-protein interactions by mass spectrometry. (PubMed id 17353931)³ Ewing R.M....Figeys D. (2007)
A protein-protein interaction network for human inherited ataxias and disorders of Purkinje cell degeneration. (PubMed id 16713569)³ Lim J....Zoghbi H.Y. (2006)

(in PubMed, OMIM, and NCBI Bookshelf)
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		AND	OR
Aliases
Free Text

Query String		PubMed OMIM NCBI Bookshelf
	(Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, and/or H-InvDB)
About This Section

Entrez Gene: 166	HGNC: 307	AceView: AES	Ensembl:ENSG00000104964	euGenes: HUgn166
ECgene: AES	H-InvDB: AES

(According to HUGE)
About This Section

(According to ATLAS, HORDE, IMGT, MTDB, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section

Name	Description
ATLAS Chromosomes in Cancer entry for AES	Genetics and Cytogenetics in Oncology and Haematology

Licensable Technologies for AES
(Available from WIS Yeda, Salk, Tufts)

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(Reagents available from Applied Biosystems, Antibodies and assays by Cell Signaling Technology, Abcam, Novus Biologicals,
Sigma-Aldrich, R&D Systems, Millipore, Abnova, and/or Invitrogen, Clones available from OriGene,and/or Invitrogen, Drugs and/or compounds by Sigma-Aldrich,
Enzo Life Sciences, and/or Tocris Bioscience)
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Products for AES:

TaqMan ® Gene Expression Assays

TaqMan ® Genotyping Assays

Free SNP selection tool

Invitrogen iPath Pathways	Invitrogen BLOCK-iT™ RNAi
Invitrogen Antibodies	Invitrogen Assays
Invitrogen Clones	Invitrogen Q-PCR Products
Invitrogen Human Recombinant Kinases	Invitrogen Custom Antibody and Peptide Service
Invitrogen Proteins / Assays / Screening Services	Search Invitrogen catalog for AES-related products

	Millipore Custom Antibody & Bulk Services
	Millipore Preclinical / Clinical Development Services
	Millipore Immunoassay Services
	Millipore Target Screening & Profiling Services

	Predesigned and custom siRNAs for AES		Antibodies for AES
	Explore super-pooled esiRNAs		Browse proteins at Sigma-Aldrich
	Lentivirus-delivered shRNAs for AES		Browse small molecules at Sigma-Aldrich
	"Your Favorite Gene" Pathways		feedback

	Antibodies		Primer Pairs
	Cell Culture Products		ELISAs
	Flow Cytometry Kits		Protease Activity Assays & Reagents
	Cell Selection/Detection Kits & Reagents		ELISA/Assay Development Kits & Reagents
	Multiplex/Array Assay Kits & Reagents		ELISpot Kits & Development Modules
	Recombinant & Natural Proteins

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AES Gene

protein-coding GIFtS: 59

Aliases &
Descriptions
for AES

Summaries
for AES

Genomic Location
for AES

Proteins
for AES

Protein Domains/
Families
for AES

Gene Function
for AES

Pathways & Interactions
for AES

Drugs & Compounds
for AES

Transcripts
for AES

Expression
for AES

Orthologs
for AES

Paralogs
for AES

SNPs/Variants
for AES

Disorders & Mutations
for AES

Medical News
for AES

Publications
for AES

Search for AES

Genome Databases showing AES

Other Databases showing AES

Specialized Databases showing AES

Licensable Technologies
for AES

Services
for AES

Gene Index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

AES Gene

protein-coding GIFtS: 59

Aliases & Descriptionsfor AES

Summariesfor AES

Genomic Locationfor AES

Proteinsfor AES

Protein Domains/Familiesfor AES

Gene Functionfor AES

Pathways & Interactionsfor AES

Drugs & Compoundsfor AES

Transcriptsfor AES

Expression for AES

Orthologsfor AES

Paralogsfor AES

SNPs/Variantsfor AES

Disorders & Mutationsfor AES

Medical Newsfor AES

Publicationsfor AES

Search for AES

Genome Databases showing AES

Other Databases showing AES

Specialized Databases showing AES

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Gene Index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

Aliases &
Descriptions
for AES

Summaries
for AES

Genomic Location
for AES

Proteins
for AES

Protein Domains/
Families
for AES

Gene Function
for AES

Pathways & Interactions
for AES

Drugs & Compounds
for AES

Transcripts
for AES

Expression
for AES

Orthologs
for AES

Paralogs
for AES

SNPs/Variants
for AES

Disorders & Mutations
for AES

Medical News
for AES

Publications
for AES

Licensable Technologies
for AES

Services
for AES