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AEN Gene

protein-coding   GIFtS: 53
GCID: GC15P089164

Apoptosis Enhancing Nuclease

(Previous name: interferon stimulated exonuclease gene 20kDa-like 1)
(Previous symbol: ISG20L1)
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(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Apoptosis Enhancing Nuclease1 2     Apoptosis-Enhancing Nuclease2
ISG20L11 2 3 5     pp127442
Interferon Stimulated Exonuclease Gene 20kDa-Like 11 2     EC 3.1.-.-3
Interferon-Stimulated 20 KDa Exonuclease-Like 12 3     EC 3.1.13.18

External Ids:    HGNC: 257221   Entrez Gene: 647822   Ensembl: ENSG000001810267   OMIM: 6101775   UniProtKB: Q8WTP83   

Export aliases for AEN gene to outside databases

Previous GC identifers: GC15P086967 GC15P065276


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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GeneCards Summary for AEN Gene:
AEN (apoptosis enhancing nuclease) is a protein-coding gene. GO annotations related to this gene include exonuclease activity and nucleic acid binding. An important paralog of this gene is ISG20.

UniProtKB/Swiss-Prot: AEN_HUMAN, Q8WTP8
Function: Exonuclease with activity against single- and double-stranded DNA and RNA. Mediates p53-induced
apoptosis. When induced by p53 following DNA damage, digests double-stranded DNA to form single-stranded DNA and
amplifies DNA damage signals, leading to enhancement of apoptosis




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000015.9  NT_010194.18  NC_018926.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the AEN gene promoter:
         RFX1   STAT1   Olf-1   E47   HEN1   Pax-3   FOXJ2 (long isoform)   Hand1   Chx10   FOXJ2   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidAEN promoter sequence
   Search Chromatin IP Primers for AEN

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat AEN


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 15q26.1   Ensembl cytogenetic band:  15q26.1   HGNC cytogenetic band: 15q26.1

AEN Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
AEN gene location

GeneLoc information about chromosome 15         GeneLoc Exon Structure

GeneLoc location for GC15P089164:  view genomic region     (about GC identifiers)

Start:
89,164,527 bp from pter      End:
89,175,513 bp from pter
Size:
10,987 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., eBioscience, and/or antibodies-online,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., eBioscience, and/or antibodies-online, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, Cloud-Clone Corp, antibodies-online, and/or others.)
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UniProtKB/Swiss-Prot: AEN_HUMAN, Q8WTP8 (See protein sequence)
Recommended Name: Apoptosis-enhancing nuclease  
Size: 325 amino acids; 36350 Da
Sequence caution: Sequence=AAH14407.1; Type=Erroneous initiation; Note=Translation N-terminally extended;
Sequence=BAB14091.1; Type=Erroneous initiation; Note=Translation N-terminally extended;
Secondary accessions: C9J571 Q9BSA5 Q9H9X7
Alternative splicing: 2 isoforms:  Q8WTP8-1   Q8WTP8-2   

Explore the universe of human proteins at neXtProt for AEN: NX_Q8WTP8

Explore proteomics data for AEN at MOPED

Post-translational modifications: 

  • Ubiquitination2 at Lys170
  • Modification sites at PhosphoSitePlus
  • 2 DME Specific Peptides for AEN (Q8WTP8)
     HSSVEDA  VLYDKYIRPE 


    See AEN Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_073604.3  
    ENSEMBL proteins: 
     ENSP00000331944   ENSP00000453631   ENSP00000368533  

    AEN Human Recombinant Protein Products:

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    Novus Biologicals AEN Lysates
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    Cloud-Clone Corp. Proteins for AEN

     
    Search eBioscience for Proteins for AEN 

     
    antibodies-online proteins for AEN (3 products) 

     
    Search antibodies-online for peptides for AEN

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    antibodies-online antibodies for AEN (16 products) 

    AEN Assay Products:

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    Cloud-Clone Corp. ELISAs for AEN
    Cloud-Clone Corp. CLIAs for AEN
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    antibodies-online kits for AEN (6 products) 


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    3 InterPro protein domains:
     IPR013520 Exonuclease_RNaseT/DNA_pol3
     IPR006055 Exonuclease
     IPR012337 RNaseH-like_dom

    Graphical View of Domain Structure for InterPro Entry Q8WTP8

    ProtoNet protein and cluster: Q8WTP8

    2 Blocks protein domains:
    IPB006055 Exonuclease
    IPB013520 Exonuclease


    UniProtKB/Swiss-Prot: AEN_HUMAN, Q8WTP8
    Similarity: Contains 1 exonuclease domain


    Find genes that share domains with AEN           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: AEN_HUMAN, Q8WTP8
    Function: Exonuclease with activity against single- and double-stranded DNA and RNA. Mediates p53-induced
    apoptosis. When induced by p53 following DNA damage, digests double-stranded DNA to form single-stranded DNA and
    amplifies DNA damage signals, leading to enhancement of apoptosis
    Induction: Up-regulated by p53/TP53 in response to ionizing radiation and DNA-damaging agents such as adriamycin.
    Phosphorylation of p53/TP53 at 'Ser-15' is required for effective induction

         Enzyme Numbers (IUBMB): EC 3.1.-.-1 EC 3.1.13.12

         Gene Ontology (GO): 2 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003676nucleic acid binding IEA--
    GO:0004527exonuclease activity IDA16171785
         
    Find genes that share ontologies with AEN           About GenesLikeMe


    Animal Models:
       genOway: Develop your customized and physiologically relevant rodent model for AEN

    miRNA
    Products:
        
    miRTarBase miRNAs that target AEN:
    hsa-mir-186-5p (MIRT021177), hsa-mir-193b-5p (MIRT038005), hsa-mir-26b-5p (MIRT029335)

    Block miRNA regulation of human, mouse, rat AEN using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate AEN (see all 20):
    hsa-miR-3934 hsa-let-7d hsa-miR-1224-3p hsa-miR-106a hsa-let-7c hsa-let-7g hsa-let-7a hsa-miR-93
    SwitchGear 3'UTR luciferase reporter plasmidAEN 3' UTR sequence
    Inhib. RNA
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    Predesigned siRNA for gene silencing in human, mouse, rat AEN

    Gene Editing
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    GenScript: all cDNA clones in your preferred vector: AEN (NM_022767)
    Browse Sino Biological Human cDNA Clones
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for AEN
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat AEN

    Cell Line
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    In Situ Assay
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for AEN


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    AEN_HUMAN, Q8WTP8: Nucleus. Nucleus, nucleolus. Note=Localized predomintly in the nucleolus. Translocates from
    the nucleolus to the nucleoplasm upon apoptosis induction
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    nucleus5
    cytosol2
    vacuole1

    Gene Ontology (GO): 4 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus IDA--
    GO:0005654nucleoplasm IDA16171785
    GO:0005730nucleolus IDA--
    GO:0031965nuclear membrane IDA--

    Find genes that share ontologies with AEN           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for AEN
    Interactions:

        Search GeneGlobe Interaction Network for AEN

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for AEN (Q8WTP83 ENSP000003319444) via UniProtKB, MINT, STRING, and/or I2D (see all 34)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    ZFP64Q9NPA53I2D: score=1 
    NOP58ENSP000002642794STRING: ENSP00000264279
    NCBP2ENSP000003268064STRING: ENSP00000326806
    NCBP2LENSP000003614544STRING: ENSP00000361454
    CEBPZENSP000002341704STRING: ENSP00000234170
    About this table

    Gene Ontology (GO): 3 biological process terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0010212response to ionizing radiation IDA16171785
    GO:0042771intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator IDA18264133
    GO:0090305nucleic acid phosphodiester bond hydrolysis IDA16171785

    Find genes that share ontologies with AEN           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for AEN



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for AEN gene: 
    NM_022767.3  

    Unigene Cluster for AEN:

    Apoptosis enhancing nuclease
    Hs.436102  [show with all ESTs]
    Unigene Representative Sequence: AB209323
    7 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000332810(uc002bmt.2 uc010bnm.1) ENST00000557787(uc010bnl.2)
    ENST00000559528 ENST00000560174 ENST00000558327 ENST00000557927 ENST00000379231

    miRNA
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    Block miRNA regulation of human, mouse, rat AEN using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate AEN (see all 20):
    hsa-miR-3934 hsa-let-7d hsa-miR-1224-3p hsa-miR-106a hsa-let-7c hsa-let-7g hsa-let-7a hsa-miR-93
    SwitchGear 3'UTR luciferase reporter plasmidAEN 3' UTR sequence
    Inhib. RNA
    Products:
         
    OriGene RNAi products in human, mouse, rat for AEN
    Predesigned siRNA for gene silencing in human, mouse, rat AEN
    Clone
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    OriGene ORF clones in mouse, rat for AEN
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: AEN (NM_022767)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for AEN
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat AEN
    Primer
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    OriGene qPCR primer pairs and template standards for AEN
    OriGene qSTAR qPCR primer pairs in human, mouse for AEN
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat AEN
      QuantiTect SYBR Green Assays in human, mouse, rat AEN
      QuantiFast Probe-based Assays in human, mouse, rat AEN

    Additional mRNA sequence: 

    AB209323.1 AF318330.1 AF327352.1 AK022546.1 AK022624.1 AK128623.1 AK308119.1 BC005164.1 
    BC014407.1 BC020988.1 

    11 DOTS entries:

    DT.75103713  DT.100764611  DT.100785255  DT.100785245  DT.121036988  DT.95073379  DT.99949586  DT.100785254 
    DT.102843984  DT.97768521  DT.100785256 

    Selected AceView cDNA sequences (see all 276):

    BM759943 AI752192 BX283892 BM745692 CB120991 BM801751 BM504615 BM477244 
    AA227388 BQ271083 BG251867 BM556125 BU154767 AK022546 BX327117 BU944799 
    AU123299 BE903208 AA613043 BG329274 BG764396 BQ953546 BI258978 AA993062 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    AEN expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: GTGAGCCACA
    AEN Expression
    About this image


    AEN expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 3) fully expand
     
     Inner Cell Mass (Early Embryonic Tissues)    fully expand to see all 2 entries
             Human embryonic stem cells (family)
     
     Blood (Cardiovascular System)
             Definitive Hematopoietic Stem Cells Definitive Yolk Sac
     
     Yolk Sac (Extraembryonic Tissues)
             Definitive Hematopoietic Stem Cells Definitive Yolk Sac
    AEN Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    AEN Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.436102
        Custom PCR Arrays for AEN
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    QuantiFast Probe-based Assays in human, mouse, rat AEN
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for AEN

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of animals and fungi.

    Orthologs for AEN gene from Selected species (see all 14)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Aen1 , 5 apoptosis enhancing nuclease1, 5 78.26(n)1
    73.29(a)1
      7 (44.83 cM)5
    680481  NM_026531.41  NP_080807.31 
     788958545 
    chicken
    (Gallus gallus)
    Aves AEN1 apoptosis enhancing nuclease 64.25(n)
    58.33(a)
      415496  XM_413869.4  XP_413869.3 
    lizard
    (Anolis carolinensis)
    Reptilia AEN6
    apoptosis enhancing nuclease
    45(a)
    1 ↔ 1
    GL343844.1(143338-149575)
    African clawed frog
    (Xenopus laevis)
    Amphibia CB944151.12   -- 73.69(n)    CB944151.1 
    zebrafish
    (Danio rerio)
    Actinopterygii isg206
    interferon-stimulated protein
    32(a)
    many ↔ many
    25(19585303-19590541) ENSDARG00000079783
    baker's yeast
    (Saccharomyces cerevisiae)
    Saccharomycetes REX46
    Putative RNA exonuclease possibly involved in pre-...
    27(a)
    1 → many
    XV(180558-181427) YOL080C


    ENSEMBL Gene Tree for AEN (if available)
    TreeFam Gene Tree for AEN (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for AEN gene
    ISG202  REXO42  ISG20L22  
    3 SIMAP similar genes for AEN using alignment to 3 protein entries:     AEN_HUMAN (see all proteins):
    pp12744    ISG20    ISG20L2

    Find genes that share paralogs with AEN           About GenesLikeMe



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for AEN (see all 393)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 15 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs2020313321,2
    C--89162539(+) ACACA-/GAGAGGAG 1 -- us2k10--------
    rs1414667441,2
    C--89162606(+) CAGAGA/GATCTG 1 -- us2k10--------
    rs1855645141,2
    --89162641(+) CTTGGG/TTGGGT 1 -- us2k10--------
    rs614820201,2
    C--89162686(+) GAGGCC/TAAGGT 1 -- us2k10--------
    rs1122487181,2
    C,F--89162709(+) AGGTCA/GGGAGT 1 -- us2k11Minor allele frequency- G:0.00WA 2
    rs1382779411,2
    C--89162722(+) GAGACA/CAGCCT 1 -- us2k10--------
    rs1438619031,2
    C--89162788(+) GTGGCA/GCGTGC 1 -- us2k10--------
    rs129167831,2
    C,F--89162813(+) GTTCCT/GGAGGC 1 -- us2k19Minor allele frequency- G:0.40NA WA CSA 134
    rs1472110421,2
    C--89162852(+) AGGCAC/GATGTT 1 -- us2k10--------
    rs49323621,2
    C,F,A,H--89162992(+) CTGAAC/GACCGC 1 -- us2k19Minor allele frequency- G:0.42NA WA EA 370

    HapMap Linkage Disequilibrium report for AEN (89164527 - 89175513 bp)

    Structural Variations
          Database of Genomic Variants (DGV) variations for AEN: --
    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing AEN
    DNA2.0 Custom Variant and Variant Library Synthesis for AEN

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 610177    OMIM disorders: --

    1 disease from the University of Copenhagen DISEASES database for AEN:
    Liver neoplasm

    Find genes that share disorders with AEN           About GenesLikeMe

    Genetic Association Database (GAD): AEN

    Export disorders for AEN gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for AEN gene, integrated from 10 sources (see all 13):
    (articles sorted by number of sources associating them with AEN)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. p53 target gene AEN is a nuclear exonuclease required for p53- dependent apoptosis. (PubMed id 18264133)1, 2, 3 Kawase T....Taya Y. (Oncogene 2008)
    2. Identification of a novel ionizing radiation-induced nuclease, AEN, and its functional characterization in apoptosis. (PubMed id 16171785)1, 2, 3 Lee J.-H.... Bae S. (Biochem. Biophys. Res. Commun. 2005)
    3. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (Nat. Genet. 2004)
    4. Systematic and quantitative assessment of the ubiquitin-modified proteome. (PubMed id 21906983)1 Kim W....Gygi S.P. (Mol. Cell 2011)
    5. ISG20L1 is a p53 family target gene that modulates genotoxic stress-induced autophagy. (PubMed id 20429933)1 Eby K.G....Pietenpol J.A. (Mol. Cancer 2010)
    6. Mouse Fem1b interacts with the Nkx3.1 homeoprotein and is required for proper male secondary sexual development. (PubMed id 18816836)1 Wang X....Shen M.M. (Dev. Dyn. 2008)
    7. Toward a confocal subcellular atlas of the human proteome. (PubMed id 18029348)1 Barbe L....Andersson-Svahn H. (amp 2008)
    8. hORFeome v3.1: a resource of human open reading frames representing over 10,000 human genes. (PubMed id 17207965)1 Lamesch P.... Vidal M. (Genomics 2007)
    9. Analysis of the DNA sequence and duplication history of human chromosome 15. (PubMed id 16572171)2 Zody M.C....Nusbaum C. (Nature 2006)
    10. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)2 Gerhard D.S.... Malek J. (Genome Res. 2004)

    (in PubMed, OMIM, and NCBI Bookshelf)
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    Aliases
    Free Text  

      Query String
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    OMIM
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      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 64782 HGNC: 25722 AceView: FLJ12484 Ensembl:ENSG00000181026 euGenes: HUgn64782
    ECgene: AEN H-InvDB: AEN

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
    About This Section

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    NameDescription
    PharmGKB entry for AEN Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for AEN gene:
    Search GeneIP for patents involving AEN

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, eBioscience, antibodies-online, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
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