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Aliases for AEBP2 Gene

Aliases for AEBP2 Gene

  • AE Binding Protein 2 2 3
  • Adipocyte Enhancer-Binding Protein 2 4
  • AE-Binding Protein 2 4

External Ids for AEBP2 Gene

Summaries for AEBP2 Gene

GeneCards Summary for AEBP2 Gene

AEBP2 (AE Binding Protein 2) is a Protein Coding gene. GO annotations related to this gene include transcription corepressor activity.

UniProtKB/Swiss-Prot for AEBP2 Gene

  • DNA-binding transcriptional repressor. May interact with and stimulate the activity of the PRC2 complex, which methylates Lys-9 and Lys-27 residues of histone H3.

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for AEBP2 Gene

Genomics for AEBP2 Gene

Genomic Location for AEBP2 Gene

Start:
19,404,045 bp from pter
End:
19,720,801 bp from pter
Size:
316,757 bases
Orientation:
Plus strand

Genomic View for AEBP2 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for AEBP2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for AEBP2 Gene

Regulatory Elements for AEBP2 Gene

Proteins for AEBP2 Gene

  • Protein details for AEBP2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q6ZN18-AEBP2_HUMAN
    Recommended name:
    Zinc finger protein AEBP2
    Protein Accession:
    Q6ZN18
    Secondary Accessions:
    • Q59FS5
    • Q6ZN62
    • Q96BG3

    Protein attributes for AEBP2 Gene

    Size:
    517 amino acids
    Molecular mass:
    54467 Da
    Quaternary structure:
    • Self-associates. Interacts with EED, EZH2, RBBP4 and SUZ12. Component of the PRC2/EED-EZH1 complex, which includes EED, EZH1, SUZ12, RBBP4 and AEBP2 (By similarity). May also interact with RBBP7.
    SequenceCaution:
    • Sequence=AAH15624.1; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=AAH22220.1; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=BAD18513.1; Type=Erroneous termination; Positions=269; Note=Translated as Gln.; Evidence={ECO:0000305}; Sequence=EAW96400.1; Type=Erroneous initiation; Evidence={ECO:0000305};

    Alternative splice isoforms for AEBP2 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for AEBP2 Gene

Proteomics data for AEBP2 Gene at MOPED

Post-translational modifications for AEBP2 Gene

  • Modification sites at PhosphoSitePlus
  • Ubiquitination at Lys303 and Lys360

Other Protein References for AEBP2 Gene

No data available for DME Specific Peptides for AEBP2 Gene

Domains for AEBP2 Gene

Protein Domains for AEBP2 Gene

UniProtKB/Swiss-Prot:

AEBP2_HUMAN
Family:
  • Belongs to the AEBP2/jing C2H2-type zinc-finger family.:
    • Q6ZN18
Similarity:
  • Contains 3 C2H2-type zinc fingers.:
    • Q6ZN18
genes like me logo Genes that share domains with AEBP2: view

No data available for Gene Families for AEBP2 Gene

Function for AEBP2 Gene

Molecular function for AEBP2 Gene

UniProtKB/Swiss-Prot Function: DNA-binding transcriptional repressor. May interact with and stimulate the activity of the PRC2 complex, which methylates Lys-9 and Lys-27 residues of histone H3.

Gene Ontology (GO) - Molecular Function for AEBP2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000978 RNA polymerase II core promoter proximal region sequence-specific DNA binding IEA --
GO:0001078 RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in negative regulation of transcription IEA --
GO:0003677 DNA binding --
GO:0003714 transcription corepressor activity IEA --
GO:0005515 protein binding IPI 25416956
genes like me logo Genes that share ontologies with AEBP2: view
genes like me logo Genes that share phenotypes with AEBP2: view

No data available for Enzyme Numbers (IUBMB) , Animal Models , Transcription Factor Targeting and HOMER Transcription for AEBP2 Gene

Localization for AEBP2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for AEBP2 Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for AEBP2 Gene COMPARTMENTS Subcellular localization image for AEBP2 gene
Compartment Confidence
nucleus 5

Gene Ontology (GO) - Cellular Components for AEBP2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus --
GO:0005654 nucleoplasm TAS --
GO:0035098 ESC/E(Z) complex IDA 20075857
genes like me logo Genes that share ontologies with AEBP2: view

Pathways for AEBP2 Gene

SuperPathways for AEBP2 Gene

No Data Available

Gene Ontology (GO) - Biological Process for AEBP2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000122 negative regulation of transcription from RNA polymerase II promoter IEA --
GO:0006325 chromatin organization TAS --
GO:0006351 transcription, DNA-templated IEA --
GO:0006355 regulation of transcription, DNA-templated --
GO:0010467 gene expression TAS --
genes like me logo Genes that share ontologies with AEBP2: view

No data available for Pathways by source for AEBP2 Gene

Transcripts for AEBP2 Gene

Unigene Clusters for AEBP2 Gene

AE binding protein 2:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for AEBP2 Gene

No ASD Table

Relevant External Links for AEBP2 Gene

GeneLoc Exon Structure for
AEBP2
ECgene alternative splicing isoforms for
AEBP2

Expression for AEBP2 Gene

mRNA expression in normal human tissues for AEBP2 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for AEBP2 Gene

SOURCE GeneReport for Unigene cluster for AEBP2 Gene Hs.126497

genes like me logo Genes that share expressions with AEBP2: view

Orthologs for AEBP2 Gene

This gene was present in the common ancestor of animals.

Orthologs for AEBP2 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia AEBP2 36
  • 99.4 (n)
  • 99.8 (a)
AEBP2 37
  • 100 (a)
OneToOne
cow
(Bos Taurus)
Mammalia AEBP2 36
  • 95.82 (n)
  • 97.25 (a)
AEBP2 37
  • 98 (a)
OneToOne
dog
(Canis familiaris)
Mammalia AEBP2 36
  • 98.07 (n)
  • 100 (a)
AEBP2 37
  • 100 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Aebp2 36
  • 87.96 (n)
  • 91.28 (a)
Aebp2 16
Aebp2 37
  • 93 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia -- 37
  • 95 (a)
OneToMany
-- 37
  • 77 (a)
OneToMany
platypus
(Ornithorhynchus anatinus)
Mammalia AEBP2 37
  • 62 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Aebp2 36
  • 91.34 (n)
  • 96.75 (a)
chicken
(Gallus gallus)
Aves AEBP2 36
  • 88.82 (n)
  • 96.35 (a)
AEBP2 37
  • 88 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia AEBP2 37
  • 95 (a)
OneToOne
African clawed frog
(Xenopus laevis)
Amphibia Xl.5603 36
zebrafish
(Danio rerio)
Actinopterygii aebp2 36
  • 73.29 (n)
  • 84.25 (a)
aebp2 37
  • 65 (a)
OneToOne
Dr.24760 36
fruit fly
(Drosophila melanogaster)
Insecta jing 37
  • 9 (a)
OneToOne
sea squirt
(Ciona savignyi)
Ascidiacea -- 37
  • 33 (a)
OneToOne
Species with no ortholog for AEBP2:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for AEBP2 Gene

ENSEMBL:
Gene Tree for AEBP2 (if available)
TreeFam:
Gene Tree for AEBP2 (if available)

Paralogs for AEBP2 Gene

genes like me logo Genes that share paralogs with AEBP2: view

No data available for Paralogs for AEBP2 Gene

Variants for AEBP2 Gene

Sequence variations from dbSNP and Humsavar for AEBP2 Gene

SNP ID Clin Chr 12 pos Sequence Context AA Info Type MAF
rs3283 -- 19,461,226(-) TCAGA(C/T)TAAAT intron-variant
rs14132 -- 19,521,247(+) TCTTG(C/G)TAATA utr-variant-3-prime, downstream-variant-500B
rs955153 -- 19,517,669(-) CCCAG(G/T)GCTTA intron-variant
rs1469519 -- 19,442,509(+) AGGAA(A/G)TGGAG intron-variant
rs1875467 -- 19,469,411(-) ACGTG(G/T)TAAGT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for AEBP2 Gene

Variant ID Type Subtype PubMed ID
esv33101 CNV Gain 17666407
nsv832346 CNV Loss 17160897
nsv516783 CNV Loss 19592680

Relevant External Links for AEBP2 Gene

HapMap Linkage Disequilibrium report
AEBP2

Disorders for AEBP2 Gene

(1) University of Copenhagen DISEASES for AEBP2 Gene

Relevant External Links for AEBP2

Genetic Association Database (GAD)
AEBP2
genes like me logo Genes that share disorders with AEBP2: view

No data available for UniProtKB/Swiss-Prot for AEBP2 Gene

Publications for AEBP2 Gene

  1. SUZ12 is required for both the histone methyltransferase activity and the silencing function of the EED-EZH2 complex. (PMID: 15225548) Cao R. … Zhang Y. (Mol. Cell 2004) 3 4
  2. Cloning and characterization of a novel zinc finger transcriptional repressor. A direct role of the zinc finger motif in repression. (PMID: 10329662) He G.P. … Ro H.S. (J. Biol. Chem. 1999) 2 3
  3. Role of histone H3 lysine 27 methylation in Polycomb-group silencing. (PMID: 12351676) Cao R. … Zhang Y. (Science 2002) 3 4
  4. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg R.L. … Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002) 3
  5. AEBP2 as a potential targeting protein for Polycomb Repression Complex PRC2. (PMID: 19293275) Kim H. … Kim J. (Nucleic Acids Res. 2009) 23

Products for AEBP2 Gene

Sources for AEBP2 Gene

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