AEBP2 Gene
protein-coding GIFtS : 49 GCID: GC12 P019556
AE binding protein 2
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Aliasesfor AEBP2 gene
(According to
1 HGNC ,
2 Entrez Gene ,
3 UniProtKB/Swiss-Prot ,
4 UniProtKB/TrEMBL , 5 OMIM , 6 GeneLoc ,
7 Ensembl ,
8 DME ,
9 miRBase ,
and/or 10 fRNAdb )About This Section Aliases AE Binding Protein 2 1 2 Adipocyte Enhancer-Binding Protein 22 3 AE-Binding Protein 22 3 MGC179221 AE(Adipocyte Enhancer)-Binding Protein 22 Zinc Finger Protein AEBP22
Export aliases for AEBP2 gene to outside databases Previous GC identifers: GC12P019457 GC12P019484 GC12P019483 GC12P019592
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Summariesfor AEBP2 gene (According to Entrez Gene ,
Tocris Bioscience ,
Wikipedia's
Gene Wiki ,
PharmGKB ,UniProtKB/Swiss-Prot ,
and/or
UniProtKB/TrEMBL )
About This Section UniProtKB/Swiss-Prot: AEBP2_HUMAN, Q6ZN18 Function : DNA-binding transcriptional repressor. May interact with and stimulate the activity of the PRC2 complex,which methylates 'Lys-9' and 'Lys-27' residues of histone H3
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Genomic Viewsfor AEBP2 gene
(According to
GeneLoc and/or
HGNC , and/or
Entrez Gene (NCBI build 37) ,miRBase ,UCSC (hg19) and
Ensembl (release 69) ,
Regulatory elements and Epigenetics data according to
QIAGEN ,
SABiosciences , and/or
SwitchGear Genomics )About This Section RefSeq DNA sequence: NC_000012.11 NC_018923.1 NT_009714.17 Regulatory elements: SABiosciences Regulatory transcription factor binding sites in the AEBP2 gene promoter:AREB6 Spz1 Sox5 POU2F1 POU2F1a LHX3a/Lhx3a Pax-4a C/EBPalpha Hlf Other transcription factors Search SABiosciences Chromatin IP Primers for AEBP2 Epigenetics: QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human mouse rat
Genomic Location: Genomic View : UCSC Golden Path with GeneCards custom track Entrez Gene cytogenetic band: 12p12.3 Ensembl cytogenetic band: 12p12.3 HGNC cytogenetic band: 12p12.3 AEBP2 Gene in genomic location: bands according to Ensembl, locations according to
Entrez Gene Ensembl GeneLoc information about chromosome 12 GeneLoc Exon Structure
GeneLoc location for GC12P019556: view genomic region
(about GC identifiers )
Start: 19,556,979 bp from pter End:
19,873,735 bp from pter
Size: 316,757 bases Orientation:
plus strand
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Proteinsfor AEBP2 gene
(According to
1 UniProtKB ,
HORDE ,
neXtProt ,
Ensembl ,
and/or Reactome ,
Modification sites according to 2 PhosphoSitePlus ,
Specific Peptides from DME ,
Protein expression images according to data from SPIRE MOPED and PaxDb ,
RefSeq according to NCBI ,
PDB rendering according to OCA and/or Proteopedia ,
Recombinant Proteins
from
EMD Millipore ,
R&D Systems ,
GenScript ,
Enzo Life Sciences ,
OriGene ,
Novus Biologicals ,
Sino Biological ,
ProSpec , and/or
Uscn ,
EMD Millipore ,
R&D Systems ,
OriGene ,
GenScript ,
Cell Signaling Technology ,
Enzo Life Sciences , and/or
Uscn ,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene ,
Antibodies by
EMD Millipore ,
R&D Systems ,
GenScript ,
Cell Signaling Technology ,
OriGene ,
Novus Biologicals ,
Thermo Fisher Scientific ,
Abcam , and/or
Uscn )
About This Section UniProtKB/Swiss-Prot: AEBP2_HUMAN, Q6ZN18 See
protein sequence )Recommended Name: Size : 517 amino acids; 54467 DaSubunit : Self-associates. Interacts with EED, EZH2, RBBP4 and SUZ12. Component of the PRC2/EED-EZH1 complex, whichincludes EED, EZH1, SUZ12, RBBP4 and AEBP2 (By similarity). May also interact with RBBP7
Subcellular location : Nucleus (Probable)Sequence caution : Sequence=AAH15624.1; Type=Erroneous initiation; Sequence=AAH22220.1; Type=Erroneous initiation;Sequence=BAD18513.1; Type=Erroneous termination; Positions=269; Note=Translated as Gln; Sequence=EAW96400.1; Type=Erroneous initiation;
Secondary accessions : Q59FS5 Q6ZN62 Q96BG3Alternative splicing : 3 isoforms : Q6ZN18-1 Q6ZN18-2 Q6ZN18-3 Explore the universe of human proteins at neXtProt for AEBP2: NX_Q6ZN18 Post-translational modifications:
View modification sites using PhosphoSitePlus 2 View neXtProt modification sites for NX_Q6ZN18 AEBP2 Protein expression data from MOPED and PaxDb : About this image REFSEQ proteins (3 alternative transcripts): NP_001107648.1 NP_001253972.1 NP_694939.2 ENSEMBL proteins: ENSP00000444255 ENSP00000437983 ENSP00000381840 ENSP00000266508 ENSP00000354267 ENSP00000445587 ENSP00000381715 Human Recombinant Protein Products: Gene Ontology (GO): 2 cellular component terms (GO ID links to tree view) : About this table
About GeneDecksing AEBP2 Antibody Products: Assay Products for AEBP2:
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Protein
Domains /for AEBP2 gene (According to InterPro , ProtoNet ,
UniProtKB , and/or BLOCKS ,
Sets of similar genes according to GeneDecks )
About This Section About GeneDecksing 3 InterPro domains/families :
Graphical View of Domain Structure for InterPro Entry Q6ZN18 ProtoNet protein and cluster: Q6ZN18
UniProtKB/Swiss-Prot: AEBP2_HUMAN, Q6ZN18 Similarity : Belongs to the AEBP2/jing C2H2-type zinc-finger familySimilarity : Contains 3 C2H2-type zinc fingers
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Functionfor AEBP2 gene
(According to 1 UniProtKB ,
Genatlas ,
LifeMap Discovery™ ,
IUBMB , and/or
2 DME ,
Human phenotypes from GenomeRNAi ,
Animal models from MGI Mar 06 2013,
SABiosciences ,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene ,
RNAi from
EMD Millipore ,
siRNAs from
OriGene ,
QIAGEN ,
microRNA from QIAGEN ,
Gene Editing from DNA2.0 ,
Clones from EMD Millipore ,
OriGene ,
SwitchGear Genomics ,
GenScript ,
Sino Biological ,
DNA2.0 ,
and Vector BioLabs ,
Cell Lines from GenScript ,
LifeMap BioReagents ,
In Situ Hybridization Assays from Advanced Cell Diagnostics ,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene .)
About This Section Function Summary: UniProtKB/Swiss-Prot: AEBP2_HUMAN, Q6ZN18 Function : DNA-binding transcriptional repressor. May interact with and stimulate the activity of the PRC2 complex,which methylates 'Lys-9' and 'Lys-27' residues of histone H3
Clone Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human mouse rat see all 6 )human mouse rat see all 4 )OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling GenScript: all cDNA clones in your preferred vector (see all 2 ): AEBP2 (NM_153207 ) Sino Biological Human cDNA Clone for AEBP2 DNA2.0 Custom Codon Optimized Gene
Synthesis Service for AEBP2 Vector BioLabs ready-to-use adenovirus/AAV for human , mouse , rat AEBP2
In Situ AssayAdvanced Cell Diagnostics RNAscope RNA in situ hybridization assays for AEBP2
Gene Ontology (GO): 3 molecular function terms (GO ID links to tree view) : About this table
About GeneDecksing 2 GenomeRNAi human phenotypes for AEBP2 :Animal Models: 7 MGI mutant phenotypes (inferred from 1 allele(MGI details for Aebp2) :About GeneDecksing
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Pathways & Interactionsfor AEBP2 gene
(Pathways according to
EMD Millipore ,
R&D Systems ,
Cell Signaling Technology ,
KEGG ,
PharmGKB ,
BioSystems ,
Reactome ,
Tocris Bioscience ,
GeneGo (Thomson Reuters) ,
QIAGEN ,
and/or UniProtKB ,
Sets of similar genes according to GeneDecks ,
Interaction Networks according to
SABiosciences ,
and/or STRING ,
Interactions according to 1 UniProtKB ,
2 MINT ,
3 I2D , and/or
4 STRING ,
with links to IntAct and
Ensembl ,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene) .
About This Section Interactions: Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for AEBP2 STRING Interaction
Network Preview (showing 5 interactants - click image to see 25)5/39 Interacting proteins for AEBP2 (Q6ZN18 2 , 3 ENSP00000381840 4 via UniProtKB, MINT, STRING , and/or I2D (see all 39 )About this table Gene Ontology (GO): 3 biological process terms (GO ID links to tree view) : About this table
GO ID Qualified GO term Evidence PubMed IDs GO:0006351 transcription, DNA-dependent
IEA -- GO:0006355 regulation of transcription, DNA-dependent
IEA -- GO:0016568 chromatin modification
IEA --
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Drugs & Compoundsfor AEBP2 gene (Chemical Compounds according to UniProtKB , Enzo Life Sciences ,
EMD Millipore , Tocris Bioscience
HMDB ,
BitterDB , and/or
Novoseek , and Drugs according to
DrugBank ,
Enzo Life Sciences , and/or
PharmGKB , with drugs/clinical trials/news
search links to CenterWatch )
About This Section Browse Tocris compounds for AEBP2 AEBP2
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Transcriptsfor AEBP2 gene (Secondary structures according to
fRNAdb ,Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank , Entrez Gene ,
DOTS (version 10), and/or
AceView ,
transcript ids from Ensembl
with links to UCSC , GeneLoc ,
alternative splicing isoforms according to ASD and/or
ECgene ,EMD Millipore ,
OriGene ,
QIAGEN ,
shRNA from
OriGene ,
microRNA from QIAGEN ,
OriGene ,
SwitchGear Genomics ,
GenScript ,
DNA2.0 ,
Vector BioLabs ,
Primers from
OriGene ,
SABiosciences , and/or
QIAGEN
)About This Section REFSEQ mRNAs for AEBP2 gene (3 alternative transcripts): NM_001114176.1 NM_001267043.1 NM_153207.4 Unigene Cluster for AEBP2:
AE binding protein 2 Hs.126497 [show with all ESTs ] Unigene Representative Sequence: NM_153207 7 Ensembl transcripts including schematic representations, and UCSC links where relevant : ENST00000538425 ENST00000541908 ENST00000398864 ENST00000266508 (uc001ref.2 uc001ree.2 )ENST00000360995 (uc001reg.1 ) ENST00000512223 ENST00000398731 Clone OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human mouse rat see all 6 )human mouse rat see all 4 )OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling GenScript: all cDNA clones in your preferred vector (see all 2 ): AEBP2 (NM_153207 ) DNA2.0 Custom Codon Optimized Gene
Synthesis Service for AEBP2 Vector BioLabs ready-to-use adenovirus/AAV for human , mouse , rat AEBP2
Additional cDNA sequence: AB209384.1 AK025788.1 AK126973.1 AK131361.1 AK131410.1 BC015624.2 BC022220.1
12 DOTS entries : DT.111195 DT.99951146
DT.95089176 DT.97803421 DT.100790232 DT.121211331 DT.95363341 DT.121211305 DT.121211399 DT.95089165 DT.91991685 DT.95089164 24/160 AceView cDNA sequences (see all 160 ):
CD678632 AI337664 BM680995 AA195658 BI439072 BF475808 BU192571 R74094 BG112340 BC015624 BG739792 AK131410 CA438682 AI679516 AA195771 AI357480 AK131361 NM_153207 AW513373 AW468546 AI679956 AA330300 AW316540 BI438753 GeneLoc Exon Structure
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Expression for AEBP2 gene
(RNA expression data according to
H-InvDB ,
NONCODE ,
miRBase , and
RNAdb ,
Expression images according to data from
BioGPS ,
Illumina Human BodyMap , and
CGAP
SAGE ,
Sets of similar genes according to GeneDecks ,
in vivo and in vitro expression data from LifeMap Discovery™ ,
plus additional links to
Genevestigator , and/or
SOURCE , and/or
BioGPS , and/or
UniProtKB ,SABiosciences ,
Primers from
OriGene ,
SABiosciences , and/or
QIAGEN ,
In Situ Hybridization Assays from Advanced Cell Diagnostics )
About This Section AEBP2 expression in normal human tissues (normalized intensities) See probesets specificity/sensitivity at GeneAnnot About this image BioGPS CGAP TAG: TTCTTGTAAG
About this image AEBP2 expression in embryonic tissues and stem cells About this table 2 LifeMap In Vivo Development Anatomical Compartments/CellsTissue Category (developmental path) Limb Autopod Limb Neural Tube Mesencephalic Ventricular Zone Neural Tube Expression: Experimental details:
In-situ hybridization
See AEBP2 Protein Expression from SPIRE MOPED and PaxDB Genevestigator expression for AEBP2 SOURCE GeneReport for Unigene cluster: Hs.126497 SABiosciences Expression via Pathway-Focused PCR Array including AEBP2 : Polycomb & Trithorax Complexes in human mouse rat
Primer OriGene genome-wide validated SYBR primer pairs in human mouse rat Browse OriGene validated miRNA SYBR primer pairs SABiosciences RT2 qPCR Primer Assay in human mouse rat QIAGEN QuantiTect SYBR Green Assays in human mouse rat QIAGEN QuantiFast Probe-based Assays in human mouse rat In Situ Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for AEBP2
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Orthologsfor AEBP2 gene
(Orthologs according to
1,2 HomoloGene (2 older version, for species not in 1 newer version),
3 euGenes ,
4 SGD
,
5 MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase ,
and/or
6 Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam )
About This Section Orthologs for AEBP2 gene from 6/18 species (see all 18 ) About this table
Organism
Taxonomic
Gene
Description
Human
Orthology
Details
mouse Mammalia Aebp21 5
AE binding protein 21, 5
90.18(n) 1 95.12(a) 1
6 (70.71 cM) 5 11569 1 NM_001005605.1 1 NP_001005605.1 1 140622449 5
chicken Aves AEBP21
AE binding protein 2
87.11(n) 93.84(a)
418184 XM_416415.3 XP_416415.3
lizard Reptilia AEBP26
--
95(a)
1 ↔ 1
5(8970292-8988252)
African clawed frog Amphibia Xl.56032
Xenopus laevis transcribed sequence with weak similarity more
76.11(n)
BX851683.1
zebrafish Actinopterygii Dr.247602
Danio rerio cDNA clone MGC63755 IMAGE2640498, complete more
78.75(n)
BC055234.1
fruit fly Insecta jing6
jing
9(a)
1 ↔ 1
2R(2389511-2509297)
ENSEMBL Gene Tree for AEBP2 (if available)TreeFam Gene Tree for AEBP2 (if available)
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Paralogsfor AEBP2 gene (Paralogs according to
1 HomoloGene ,2 Ensembl , and 3 SIMAP , Pseudogenes according to 4 Pseudogene.org Build 68)About This Section
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Genomic Variantsfor AEBP2 gene (SNPs/Variants according to the
1 NCBI SNP Database ,
2 Ensembl ,
3 PupaSUITE ,
UniProtKB , and
DNA2.0 ,
Linkage Disequilibrium by HapMap ,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants , Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB) , Blood group antigen gene mutations by BGMUT ,
Resequencing Primers from QIAGEN ,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences )
About This Section Genomic Data Transcription Related Data Allele Frequencies SNP ID Valid Clinical Chr 12 pos Sequence # AA Type More # Allele Pop Total More
HapMap Linkage Disequilibrium report for AEBP2 (19556979 - 19806979 bp, first 250kb of AEBP2)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions) Database of Genomic Variants (DGV): 2 variations for AEBP2 2 CNVs 49018 6972
SABiosciences Cancer Mutation PCR Assays
QIAGEN SeqTarget long-range PCR primers in human mouse rat
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Disorders
/ Diseasesfor AEBP2 gene
(in which this Gene is Involved, According to MalaCards ,
OMIM, UniProtKB ,
the University of Copenhagen DISEASES
database ,
Genatlas , GeneTests ,
GAD ,
HuGE Navigator ,
and/or TGDB .)
About This Section About GeneDecksing 2 : About MalaCards waardenburg's syndrome hirschsprung's disease 1 disease from the University of Copenhagen DISEASES database for AEBP2 :Waardenburg's syndrome Export disorders for AEBP2 gene to outside databases
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Publicationsfor AEBP2 gene (in
PubMed .
Associations of this gene to articles via
1 Entrez Gene ,
2 UniProtKB/Swiss-Prot ,
3 HGNC ,
4 GAD ,
5 PharmGKB ,
6 HMDB ,
7 DrugBank ,
8 UniProtKB/TrEMBL ,
9 Novoseek , and/or
10 fRNAdb )
About This Section PubMed articles for AEBP2 gene, integrated from 9 sources (see all 20 ):(articles sorted by number of sources associating them with AEBP2) Utopia : connect your pdf to the dynamic
SUZ12 is required for both the histone methyltransferase activity and the silencing function of the EED-EZH2 complex. (PubMed id 15225548) 1 , 2 (2004) Role of histone H3 lysine 27 methylation in Polycomb-group silencing. (PubMed id 12351676) 1 , 2 (2002) Cloning and characterization of a novel zinc finger transcriptional repressor. A direct role of the zinc finger motif in repression. (PubMed id 10329662) 1 , 3(1999) Systematic and quantitative assessment of the ubiquiti n-modified proteome. (PubMed id 21906983) 1 (2011) Genome-wide association and large-scale follow up iden tifies 16 new loci influencing lung function. (PubMed id 21946350) 1 (2011) System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation. (PubMed id 21406692) 2 (2011) Interactions of pathological hallmark proteins: tubul in polymerization promoting protein/p25, beta-amyloid, and alpha-synuclein. (PubMed id 21832049) 1 (2011) Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis. (PubMed id 20068231) 2 (2010) Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions. (PubMed id 19690332) 2 (2009) Ubiquitin-mediated proteolysis of HuR by heat shock. (PubMed id 19322201) 1 (2009)
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External Searches for AEBP2 gene
(in PubMed ,
OMIM , and NCBI Bookshelf ) About This Section
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Genome Databases showing AEBP2 gene
(According to
Entrez Gene ,
HGNC ,
AceView ,
euGenes ,
Ensembl ,
miRBase ,
ECgene ,
Kegg ,
and/or
H-InvDB )
About This Section
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Other Databases showing AEBP2 gene
(According to HUGE )
About This Section --
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Specialized Databases showing AEBP2 gene (According to PharmGKB ,
ATLAS , HORDE , IMGT , LEIDEN , UniProtKB/Swiss-Prot , and/or UniProtKB/TrEMBL ,Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot )About This Section
Name Description PharmGKB entry for AEBP2 Pharmacogenomics, SNPs, Pathways
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About This Section Patent Information for AEBP2 gene: AEBP2 GeneCards and IP: Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
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Productsfor AEBP2 gene (Antibodies, recombinant proteins, and assays from EMD Millipore , R&D Systems , OriGene , QIAGEN , GenScript , Cell Signaling Technology , SABiosciences , Novus Biologicals , Sino Biological , Enzo Life Sciences , Abcam , ProSpec , Uscn , Thermo Fisher Scientific , Gene Editing from DNA2.0 , Clones from EMD Millipore , OriGene , GenScript , Sino Biological , DNA2.0 , SwitchGear Genomics , Vector BioLabs , Cell lines from GenScript and LifeMap BioReagents , PCR Arrays from SABiosciences , Drugs and/or compounds from EMD Millipore , Tocris Bioscience , and/or
Enzo Life Sciences ), In Situ Hybridization Assays from Advanced Cell Diagnostics About This Section
Browse OriGene Antibodies OriGene shRNA RFP for AEBP2 OriGene 29mer shRNA kits in GFP-retroviral vector in human mouse rat OriGene genome-wide validated SYBR primer pairs in human mouse rat OriGene Protein Over-expression Lysate for AEBP2 Browse OriGene Fluorogenic Cell Assay Kits OriGene siRNA for AEBP2 OriGene 3'-UTR Clone for AEBP2 OriGene untagged cDNA clones in CMV expression vector in human mouse rat OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human mouse rat Browse OriGene GFP tagged cDNA clones in CMV expression vector Browse OriGene MicroRNA Expression Plasmids Browse OriGene basic RS shRNAs Browse OriGene validated miRNA SYBR primer pairs Browse OriGene full length recombinant human proteins expressed in human HEK293 cells OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling OriGene Custom Antibody Services for AEBP2 OriGene Custom Protein Services for AEBP2 OriGene Custom Immunoassay Development
QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat AEBP2 QIAGEN SeqTarget long-range PCR primers in human mouse rat QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human mouse rat QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human mouse rat QIAGEN QuantiFast Probe-based Assays in human mouse rat QIAGEN QuantiTect SYBR Green Assays in human mouse rat
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AEBP2 Proteins, Antibodies, CLIAs, and ELISAs
Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for AEBP2
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Vector BioLabs ready-to-use adenovirus/AAV for human , mouse , rat AEBP2
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Aliases for AEBP2
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Expression for AEBP2
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Expression by the Database of Embryonic development, Stem cell research, and
Regenerative medicine 
Anatomical Compartment 
Negative
Selective marker
Curated
Microarrays
