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AEBP1 Gene

protein-coding   GIFtS: 57
GCID: GC07P044143

AE Binding Protein 1

(Previous name: AE-binding protein 1)
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
AE Binding Protein 11 2
Aortic Carboxypeptidase-Like Protein1 2 3
AE-Binding Protein 11 3
ACLP2 3
Adipocyte Enhancer Binding Protein 11
Adipocyte Enhancer-Binding Protein 12

External Ids:    HGNC: 3031   Entrez Gene: 1652   Ensembl: ENSG000001066247   OMIM: 6029815   UniProtKB: Q8IUX73   

Export aliases for AEBP1 gene to outside databases

Previous GC identifers: GC07P043790 GC07P043850 GC07P043884 GC07P043917 GC07P044110 GC07P044029


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for AEBP1 Gene:
This gene encodes a member of carboxypeptidase A protein family. The encoded protein may function as a
transcriptional repressor and play a role in adipogenesis and smooth muscle cell differentiation. Studies in mice
suggest that this gene functions in wound healing and abdominal wall development. Overexpression of this gene is
associated with glioblastoma. (provided by RefSeq, May 2013)

GeneCards Summary for AEBP1 Gene:
AEBP1 (AE binding protein 1) is a protein-coding gene. Diseases associated with AEBP1 include gastroschisis, and obesity. GO annotations related to this gene include calmodulin binding and sequence-specific DNA binding transcription factor activity. An important paralog of this gene is CPZ.

UniProtKB/Swiss-Prot: AEBP1_HUMAN, Q8IUX7
Function: May positively regulate MAP-kinase activity in adipocytes, leading to enhanced adipocyte proliferation
and reduced adipocyte differentiation (By similarity). May also positively regulate NF-kappa-B activity in
macrophages by promoting the phosphorylation and subsequent degradation of I-kappa-B-alpha (NFKBIA), leading to
enhanced macrophage inflammatory responsiveness (By similarity). Can act as a transcriptional repressor (By
similarity)




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence:
NC_000007.14  NC_018918.2  NT_007819.18  
Regulatory elements:
   Regulatory transcription factor binding sites in the AEBP1 gene promoter:
         AREB6   SRF   PPAR-gamma1   Sp1   SRF (504 AA)   Olf-1   PPAR-gamma2   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmids (see all 9): AEBP1 promoter sequence
   Search Chromatin IP Primers for AEBP1

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat AEBP1


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 7p13   Ensembl cytogenetic band:  7p13   HGNC cytogenetic band: 7p

AEBP1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
AEBP1 gene location

GeneLoc information about chromosome 7         GeneLoc Exon Structure

GeneLoc location for GC07P044143:  view genomic region     (about GC identifiers)

Start:
44,143,960 bp from pter      End:
44,154,161 bp from pter
Size:
10,202 bases      Orientation:
plus strand

1 alternative location:
Chr7+,CRA_TCAG 44,183,452-44,193,654     

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
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UniProtKB/Swiss-Prot: AEBP1_HUMAN, Q8IUX7 (See protein sequence)
Recommended Name: Adipocyte enhancer-binding protein 1 precursor  
Size: 1158 amino acids; 130929 Da
Subunit: Interacts with GNG5, NFKBIA, MAPK1, MAPK3 and PTEN (By similarity). May interact with calmodulin (By
similarity). Binds to DNA in vitro (By similarity)
Caution: Although related to peptidase M14 family, lacks the active sites residues and zinc-binding sites,
suggesting that it has no carboxypeptidase activity
Sequence caution: Sequence=BAD92981.1; Type=Erroneous initiation;
Secondary accessions: Q14113 Q59ER7 Q6ZSC7 Q7KZ79
Alternative splicing: 2 isoforms:  Q8IUX7-1   Q8IUX7-2   (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for AEBP1: NX_Q8IUX7

Explore proteomics data for AEBP1 at MOPED

Post-translational modifications: 

  • Phosphorylated by MAPK1 in vitro (By similarity)1
  • Ubiquitination2 at Lys753
  • Glycosylation2 at Asn528, Asn922
  • Modification sites at PhosphoSitePlus

  • See AEBP1 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_001120.3  
    ENSEMBL proteins: 
     ENSP00000223357   ENSP00000411277   ENSP00000401758   ENSP00000400660   ENSP00000397241  
     ENSP00000398878   ENSP00000410349   ENSP00000416568  

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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    IUPHAR Guide to PHARMACOLOGY protein family classification: AE binding protein 1
    Metallocarboxypeptidases

    5 InterPro protein domains:
     IPR008969 CarboxyPept-like_regulatory
     IPR014766 CarboxyPept_regulatory_dom
     IPR008979 Galactose-bd-like
     IPR000834 Peptidase_M14
     IPR000421 Coagulation_fac_5/8-C_type_dom

    Graphical View of Domain Structure for InterPro Entry Q8IUX7

    ProtoNet protein and cluster: Q8IUX7

    1 Blocks protein domain: IPB000421 Coagulation factor 5/8 type C domain (FA58C)

    UniProtKB/Swiss-Prot: AEBP1_HUMAN, Q8IUX7
    Similarity: Belongs to the peptidase M14 family
    Similarity: Contains 1 F5/8 type C domain


    AEBP1 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: AEBP1_HUMAN, Q8IUX7
    Function: May positively regulate MAP-kinase activity in adipocytes, leading to enhanced adipocyte proliferation
    and reduced adipocyte differentiation (By similarity). May also positively regulate NF-kappa-B activity in
    macrophages by promoting the phosphorylation and subsequent degradation of I-kappa-B-alpha (NFKBIA), leading to
    enhanced macrophage inflammatory responsiveness (By similarity). Can act as a transcriptional repressor (By
    similarity)

         Gene Ontology (GO): Selected molecular function terms (see all 7):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003677DNA binding IEA--
    GO:0003700sequence-specific DNA binding transcription factor activity TAS8920928
    GO:0003714transcription corepressor activity IEA--
    GO:0004180carboxypeptidase activity TAS8920928
    GO:0004181metallocarboxypeptidase activity IEA--
         
    AEBP1 for ontologies           About GeneDecksing


    Phenotypes:
         1 GenomeRNAi human phenotype for AEBP1:
     Increased G1 DNA content 

         11 MGI mutant phenotypes (inferred from 2 alleles(MGI details for Aebp1):
     adipose tissue  behavior/neurological  cellular  digestive/alimentary  endocrine/exocrine gland 
     growth/size/body  homeostasis/metabolism  integument  limbs/digits/tail  liver/biliary system 
     mortality/aging 

    AEBP1 for phenotypes           About GeneDecksing

    Animal Models:
         MGI mouse knock-outs for AEBP1: Aebp1tm1Mdl Aebp1tm1Hsro

       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for AEBP1
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       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for AEBP1

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    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat AEBP1

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    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    AEBP1_HUMAN, Q8IUX7: Isoform 1: Secreted (By similarity)
    AEBP1_HUMAN, Q8IUX7: Isoform 2: Cytoplasm (Probable). Nucleus (Probable)
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    extracellular4
    nucleus4
    endoplasmic reticulum2
    golgi apparatus2

    Gene Ontology (GO): 5 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005615extracellular space IDA--
    GO:0005634nucleus IEA--
    GO:0005737cytoplasm IEA--
    GO:0031012colocalizes with extracellular matrix IDA--
    GO:0070062extracellular vesicular exosome IDA19199708

    AEBP1 for ontologies           About GeneDecksing


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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        Pathway & Disease-focused RT2 Profiler PCR Array including AEBP1: 
              Insulin Signaling Pathway in human mouse rat

    Interactions:

        Search GeneGlobe Interaction Network for AEBP1

    STRING Interaction Network Preview (showing 2 interactants - click image to see more details)

    Selected Interacting proteins for AEBP1 (Q8IUX72, 3 ENSP000002233574) via UniProtKB, MINT, STRING, and/or I2D (see all 7)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    TCF3P159233, ENSP000002629654I2D: score=2 STRING: ENSP00000262965
    GRB2P629933, ENSP000003390074I2D: score=1 STRING: ENSP00000339007
    PLCG1P191743I2D: score=2 
    PTK2Q053973I2D: score=2 
    GMEB2Q9UKD13I2D: score=1 
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 6):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0001501skeletal system development TAS8920928
    GO:0006351transcription, DNA-templated IEA--
    GO:0006355regulation of transcription, DNA-templated ----
    GO:0006508proteolysis ----
    GO:0007155cell adhesion IEA--

    AEBP1 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for AEBP1

    1 Novoseek inferred chemical compound relationship for AEBP1 gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    zinc 7.39 3 2017183 (2), 11161801 (1)



    AEBP1 for compounds           About GeneDecksing



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
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    REFSEQ mRNAs for AEBP1 gene: 
    NM_001129.4  

    Unigene Cluster for AEBP1:

    AE binding protein 1
    Hs.439463  [show with all ESTs]
    Unigene Representative Sequence: NM_001129
    9 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000223357(uc003tkb.3) ENST00000455443 ENST00000449162 ENST00000453052
    ENST00000454218 ENST00000434445 ENST00000450684(uc003tkc.4) ENST00000413907(uc003tkd.3)
    ENST00000431035
    miRNA
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      QuantiTect SYBR Green Assays in human, mouse, rat AEBP1
      QuantiFast Probe-based Assays in human, mouse, rat AEBP1

    Additional mRNA sequence: 

    AB209744.1 AF053944.1 AK090931.1 AK127541.1 AK296001.1 BC038588.1 D86479.1 

    19 DOTS entries:

    DT.416578  DT.97788359  DT.100663759  DT.91991375  DT.95253095  DT.100663761  DT.121045041  DT.121044993 
    DT.100663769  DT.91775044  DT.121044991  DT.121044999  DT.92021856  DT.95128411  DT.97799728  DT.99981427 
    DT.121044979  DT.40224206  DT.95105014 

    Selected AceView cDNA sequences (see all 308):

    BF344552 AA976886 BX952471 CD514819 BP349662 AA077339 BQ231970 BF338201 
    BQ182647 AI300224 BF341089 AW471279 BM672693 AL040503 CA393424 BC038588 
    CR598691 CF125153 CB268388 CD245277 AW057582 BQ015344 AA443710 AL602749 

    GeneLoc Exon Structure

    Selected Alternative Splicing Database (ASD) splice patterns (SP) for AEBP1 (see all 17)    About this scheme

    ExUns: 1 ^ 2 ^ 3a · 3b ^ 4 ^ 5a · 5b ^ 6a · 6b ^ 7 ^ 8a · 8b · 8c ^ 9a · 9b ^ 10 ^ 11 ^ 12a · 12b · 12c · 12d · 12e ^ 13a · 13b · 13c ^ 14a ·
    SP1:                                                                                                        -     -     -                                       
    SP2:                                                  -                                                     -     -     -                                       
    SP3:                                                                                                                                                            
    SP4:                                                                                                                                                            
    SP5:                                                  -                       -     -                       -     -     -                                       

    ExUns: 14b ^ 15a · 15b · 15c ^ 16a · 16b · 16c ^ 17a · 17b · 17c ^ 18a · 18b ^ 19a · 19b · 19c ^ 20 ^ 21 ^ 22 ^ 23
    SP1:        -                                         -     -                                                         
    SP2:                                                                                                                  
    SP3:                                                  -     -                                                         
    SP4:                                                        -                 -                                       
    SP5:                                                                                                                  


    ECgene alternative splicing isoforms for AEBP1

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    AEBP1 expression in normal human tissues (normalized intensities)      AEBP1 embryonic expression: see
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: ACTGGGACCT
    AEBP1 Expression
    About this image


    AEBP1 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 21) fully expand
     
     Heart (Cardiovascular System)    fully expand to see all 3 entries
             Vascular Smooth Muscle Cells Aortic Arch Arteries
             Coronary Vessels
     
     Smooth Muscle (Muscoskeletal System)    fully expand to see all 3 entries
             Vascular Smooth Muscle Cells Aortic Arch Arteries
     
     Bone (Muscoskeletal System)    fully expand to see all 2 entries
             Membranous Facial Bones
     
     Adipose (Muscoskeletal System)
             Visceral White Adipose
     
     Epithelial Cells
             Outer Root Sheath Cells Outer Root Sheath
    AEBP1 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    AEBP1 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.439463

    UniProtKB/Swiss-Prot: AEBP1_HUMAN, Q8IUX7
    Tissue specificity: Expressed in osteoblast and visceral fat

        Pathway & Disease-focused RT2 Profiler PCR Array including AEBP1: 
              Insulin Signaling Pathway in human mouse rat

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    In Situ
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for AEBP1

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of chordates.

    Orthologs for AEBP1 gene from Selected species (see all 13)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Aebp11 , 5 AE binding protein 11, 5 83.36(n)1
    84.75(a)1
      11 (3.88 cM)5
    115681  NM_009636.21  NP_033766.21 
     58619475 
    chicken
    (Gallus gallus)
    Aves AEBP16
    AE binding protein 1
    74(a)
    1 ↔ 1
    JH376336.1(21-3018)
    lizard
    (Anolis carolinensis)
    Reptilia AEBP16
    AE binding protein 1
    65(a)
    1 ↔ 1
    GL343238.1(289023-321884)
    tropical clawed frog
    (Xenopus tropicalis)
    Amphibia aebp11 AE binding protein 1 62.44(n)
    61.45(a)
      100487826  XM_002932577.2  XP_002932623.2 
    zebrafish
    (Danio rerio)
    Actinopterygii aebp16
    AEBP1 (1 of 2)6
    AE binding protein 1
    49(a)
    37(a)
    1 ↔ many
    1 ↔ many
    10(2834368-2865382) ENSDARG00000091726
    8(46740295-46781412) ENSDARG00000006901


    ENSEMBL Gene Tree for AEBP1 (if available)
    TreeFam Gene Tree for AEBP1 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for AEBP1 gene
    CPZ2  CPE2  CPXM22  CPN12  CPD2  CPM2  CPXM12  
    4 SIMAP similar genes for AEBP1 using alignment to 7 protein entries:     AEBP1_HUMAN (see all proteins):
    DKFZp666J235    CPXM1    CPXM2    CPE

    AEBP1 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for AEBP1 (see all 274)    About this table    
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 7 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1436053771,2
    Cuntested144153268(+) CACCCC/TGAGCG 2 P L mis11Minor allele frequency- T:0.00NA 4548
    rs760513871,2
    C,F--44142034(+) GTGACG/ATGCCA 1 -- us2k11Minor allele frequency- A:0.03WA 118
    rs1886801461,2
    --44142068(+) CCGCCA/GGGCTT 1 -- us2k10--------
    rs1430709471,2
    C--44142085(+) CTCAAC/TTGGGG 1 -- us2k10--------
    rs1177465771,2
    C,F--44142094(+) GGCAAC/TGGAGC 1 -- us2k11Minor allele frequency- T:0.01NA 120
    rs1482128931,2
    --44142304(+) GATCTC/TTGAGG 1 -- us2k10--------
    rs1402131321,2
    --44142346(+) GAGTGC/TCAAGA 1 -- us2k10--------
    rs1817925601,2
    --44142381(+) ATGATA/CCTGTA 1 -- us2k10--------
    rs1502350471,2
    --44142526(+) CAGGGG/TCTTGG 1 -- us2k10--------
    rs1869612681,2
    --44142763(+) TTCCCC/TACCTG 1 -- us2k10--------

    HapMap Linkage Disequilibrium report for AEBP1 (44143960 - 44154161 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 6 variations for AEBP1:    About this table    
    Variant IDTypeSubtypePubMed ID
    nsv887996CNV Loss21882294
    nsv887997CNV Loss21882294
    nsv470210CNV Loss18288195
    nsv830983CNV Loss17160897
    nsv428165CNV Gain18775914
    nsv8082CNV Gain18304495

    Site Specific Mutation Identification with PCR Assays
    Search QIAGEN SeqTarget long-range PCR primers for resequencing AEBP1
    DNA2.0 Custom Variant and Variant Library Synthesis for AEBP1

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 602981    OMIM disorders: --

    2 diseases for AEBP1:    About MalaCards
    gastroschisis    obesity

    1 disease from the University of Copenhagen DISEASES database for AEBP1:
    Gastroschisis

    AEBP1 for disorders           About GeneDecksing

    3 Novoseek inferred disease relationships for AEBP1 gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    inflammation 25 6 16461908 (1), 20396415 (1), 20419060 (1)
    immunodeficiency 11 3 2022670 (1), 11161801 (1), 2302185 (1)
    cancer 0 1 17202411 (1)


    Export disorders for AEBP1 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for AEBP1 gene, integrated from 10 sources (see all 41):
    (articles sorted by number of sources associating them with AEBP1)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. A cDNA cloning of human AEBP1 from primary cultured osteoblasts and its expression in a differentiating osteoblastic cell line. (PubMed id 8920928)1, 2, 3, 9 Ohno I....Okubo K. (Biochem. Biophys. Res. Commun. 1996)
    2. Aortic carboxypeptidase-like protein, a novel protein with discoidin and carboxypeptidase-like domains, is up-regulated during vascular smooth muscle cell differentiation. (PubMed id 9624159)1, 2, 9 Layne M.D.... Lee M.-E. (J. Biol. Chem. 1998)
    3. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (Nat. Genet. 2004)
    4. Human chromosome 7: DNA sequence and biology. (PubMed id 12690205)1, 2 Scherer S.W.... Tsui L.-C. (Science 2003)
    5. Aortic carboxypeptidase-like protein is expressed in fibrotic human lung and its absence protects against bleomycin-induced lung fibrosis. (PubMed id 19179605)1, 9 Schissel S.L....Layne M.D. (Am. J. Pathol. 2009)
    6. Regulation of IkappaBalpha function and NF-kappaB signaling: AEBP1 is a novel proinflammatory mediator in macrophages. (PubMed id 20396415)1, 9 Majdalawieh A. and Ro H.S. (Mediators Inflamm. 2010)
    7. PPARgamma1 and LXRalpha face a new regulator of macrophage cholesterol homeostasis and inflammatory responsiveness, AEBP1. (PubMed id 20419060)1, 9 Majdalawieh A. and Ro H.S. (Nucl Recept Signal 2010)
    8. Enzymic characterization of a novel member of the regulatory B-like carboxypeptidase with transcriptional repression function: stimulation of enzymic activity by its target DNA. (PubMed id 10510298)1, 9 Muise A.M. and Ro H.S. (Biochem. J. 1999)
    9. AEBP1 gene variants in infants with gastroschisis. (PubMed id 22821744)1 Feldkamp M.L....Botto L.D. (Birth Defects Res. Part A Clin. Mol. Teratol. 2012)
    10. Berberine-induced inhibition of adipocyte enhancer-binding protein 1 attenuates oxidized low-density lipoprotein accumulation and foam cell formation in phorbol 12-myristate 13-acetate-induced macrophages. (PubMed id 22796454)1 Huang Z....Huang W. (Eur. J. Pharmacol. 2012)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 165 HGNC: 303 AceView: AEBP1 Ensembl:ENSG00000106624 euGenes: HUgn165
    ECgene: AEBP1 H-InvDB: AEBP1

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
    About This Section

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    NameDescription
    PharmGKB entry for AEBP1 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for AEBP1 gene:
    Search GeneIP for patents involving AEBP1

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript, and ESI BIO, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
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