Home
GeneCards Guide
Suite
- MalaCards
- GeneALaCart
- GeneDecks
- GeneIP
- GeneLoc
Terms and Conditions
- Terms of Use
- 3rd Party Notice
About Us
User Feedback
Mirror sites

Set Analyses:

Generates a file of GeneCards annotations for your list of genes

Advanced Search

Search By

Section (entire)

for

All GeneCards Within gene subset (to enable gene prioritization):
or upload a file of gene symbols

Category Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21

GIFtS
-

AEBP1 Gene

protein-coding GIFtS: 54
GCID: GC07P044143

AE binding protein 1

(Previous name: AE-binding protein 1 )

Explore 4 diseases affiliated with
AEBP1 via

MalaCards

our new
Human Malady Compendium

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc, ⁷Ensembl, ⁸DME, ⁹miRBase, and/or ¹⁰fRNAdb)
About This Section

Aliases
AE Binding Protein 1¹ ²
ACLP¹ ² ³
AE-Binding Protein 1¹ ² ³
Aortic Carboxypeptidase-Like Protein² ³
Adipocyte Enhancer Binding Protein 1²
Adipocyte Enhancer-Binding Protein 1²

External Ids:	HGNC: 303¹	Entrez Gene: 165²	Ensembl: ENSG00000106624⁷	OMIM: 602981⁵	UniProtKB: Q8IUX7³

Export aliases for AEBP1 gene to outside databases

Previous GC identifers: GC07P043790 GC07P043850 GC07P043884 GC07P043917 GC07P044110 GC07P044029

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for AEBP1:

The adipocyte enhancer binding protein 1 is a transcriptional repressor with carboxypeptidase (CP) activity. This

protein binds to a regulatory sequence, adipocyte enhancer 1 (AE-1), located in the proximal promoter region of the

adipose P2 (aP2) gene, which encodes the adipocyte fatty-acid binding protein. It is characterized as a member of the

regulatory B-like CP family. This protein seems to be activated by a novel mechanism, whereby the direct binding of

DNA enhances its protease activity. Adipocyte-enhancer binding protein 1 may play a role in differentiated vascular

smooth muscle cells. (provided by RefSeq, Jul 2008)

UniProtKB/Swiss-Prot: AEBP1_HUMAN, Q8IUX7

Function: May positively regulate MAP-kinase activity in adipocytes, leading to enhanced adipocyte proliferation and

reduced adipocyte differentiation (By similarity). May also positively regulate NF-kappa-B activity in macrophages by

promoting the phosphorylation and subsequent degradation of I-kappa-B-alpha (NFKBIA), leading to enhanced macrophage

inflammatory responsiveness (By similarity). Can act as a transcriptional repressor (By similarity)

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section

RefSeq DNA sequence:

NC_000007.13 NC_018918.1 NT_007819.17 NT_079592.2

Regulatory elements:

SABiosciences Regulatory transcription factor binding sites in the AEBP1 gene promoter:
AREB6 SRF PPAR-gamma1 Sp1 SRF (504 AA) Olf-1 PPAR-gamma2
Other transcription factors

SwitchGear Promoter luciferase reporter plasmids (see all 9): AEBP1 promoter sequence

Search SABiosciences Chromatin IP Primers for AEBP1

Epigenetics:

QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat AEBP1

Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 7p13 Ensembl cytogenetic band: 7p13 HGNC cytogenetic band: 7p

AEBP1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
AEBP1 gene location

GeneLoc information about chromosome 7 GeneLoc Exon Structure

GeneLoc location for GC07P044143: view genomic region (about GC identifiers)

Start:	44,143,960 bp from pter	End:	44,154,161 bp from pter
Size:	10,202 bases	Orientation:	plus strand

1 alternative location:

Chr7+,CRA_TCAG 44,183,452-44,193,654

(According to ¹UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to ²PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section

UniProtKB/Swiss-Prot: AEBP1_HUMAN, Q8IUX7 (See protein sequence)

Recommended Name: Adipocyte enhancer-binding protein 1 precursor

Size: 1158 amino acids; 130929 Da

Subunit: Interacts with GNG5, NFKBIA, MAPK1, MAPK3 and PTEN (By similarity). May interact with calmodulin (By

similarity). Binds to DNA in vitro (By similarity)

Subcellular location: Isoform 1: Secreted (By similarity)

Subcellular location: Isoform 2: Cytoplasm (Probable). Nucleus (Probable)

Caution: Although related to peptidase M14 family, lacks the active sites residues and zinc-binding sites, suggesting

that it has no carboxypeptidase activity

Sequence caution: Sequence=BAD92981.1; Type=Erroneous initiation;

Secondary accessions: Q14113 Q59ER7 Q6ZSC7 Q7KZ79

Alternative splicing: 2 isoforms: Q8IUX7-1 Q8IUX7-2 (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for AEBP1: NX_Q8IUX7

Post-translational modifications:

Phosphorylated by MAPK1 in vitro (By similarity)¹

View modification sites using PhosphoSitePlus²

View neXtProt modification sites for NX_Q8IUX7

AEBP1 Protein expression data from MOPED and PaxDb: About this image

REFSEQ proteins: NP_001120.3

ENSEMBL proteins:

ENSP00000223357 ENSP00000411277 ENSP00000401758 ENSP00000400660 ENSP00000397241

ENSP00000398878 ENSP00000410349 ENSP00000416568

Human Recombinant Protein Products:

	Browse Purified and Recombinant Proteins at EMD Millipore
	Browse R&D Systems for human recombinant proteins
	Browse recombinant and purified proteins available from Enzo Life Sciences
	Browse OriGene full length recombinant human proteins expressed in human HEK293 cells Browse OriGene Protein Over-expression Lysates OriGene Custom Protein Services for AEBP1
	GenScript Custom Purified and Recombinant Proteins Services for AEBP1
	Novus Biologicals AEBP1 Protein
	Browse Sino Biological Recombinant Proteins
	Browse ProSpec Recombinant Proteins
	Uscn Proteins for AEBP1

Gene Ontology (GO): 4 cellular component terms (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005615	extracellular space	IDA	--
GO:0005634	nucleus	IEA	--
GO:0005737	cytoplasm	IEA	--
GO:0031012	colocalizes with extracellular matrix	IDA	--

AEBP1 for ontologies About GeneDecksing

AEBP1 Antibody Products:

	Browse EMD Millipore's Extensive Line of Mono- and Polyclonal Antibodies
	R&D Systems Antibodies for AEBP1 (ACLP)
	Browse OriGene Antibodies OriGene Custom Antibody Services for AEBP1
	GenScript Custom Superior Antibodies Services for AEBP1
	Novus Biologicals AEBP1 Antibodies
	Search for Antibodies for AEBP1 at Abcam
	Uscn Antibodies for AEBP1
	ThermoFisher Antibodies for AEBP1

Assay Products for AEBP1:

	Browse Kits and Assays available from EMD Millipore
	OriGene Custom Immunoassay Development Browse OriGene Fluorogenic Cell Assay Kits
	Browse R&D Systems for biochemical assays
	GenScript Custom Assay Services for AEBP1
	Browse Enzo Life Sciences for kits & assays
	Uscn ELISAs and CLIAs for AEBP1

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

AEBP1 for domains About GeneDecksing

5 InterPro domains/families:

IPR000834 Peptidase_M14

IPR000421 Coagulation_fac_5/8-C_type_dom

IPR008969 CarboxyPept-like_regulatory

IPR014766 CarboxyPept_regulatory_dom

IPR008979 Galactose-bd-like

Graphical View of Domain Structure for InterPro Entry Q8IUX7

ProtoNet protein and cluster: Q8IUX7

1 Blocks protein family: IPB000421 Coagulation factor 5/8 type C domain (FA58C)

UniProtKB/Swiss-Prot: AEBP1_HUMAN, Q8IUX7

Similarity: Belongs to the peptidase M14 family

Similarity: Contains 1 F5/8 type C domain

(According to ¹UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or ²DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
About This Section

Function Summary:

UniProtKB/Swiss-Prot: AEBP1_HUMAN, Q8IUX7

Function: May positively regulate MAP-kinase activity in adipocytes, leading to enhanced adipocyte proliferation and

reduced adipocyte differentiation (By similarity). May also positively regulate NF-kappa-B activity in macrophages by

promoting the phosphorylation and subsequent degradation of I-kappa-B-alpha (NFKBIA), leading to enhanced macrophage

inflammatory responsiveness (By similarity). Can act as a transcriptional repressor (By similarity)

miRNA Products:		OriGene 3'-UTR Clone: AEBP1 Browse MicroRNA Expression Plasmids
		QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat AEBP1
		Search QIAGEN for miScript miRNA Assays for microRNAs that regulate AEBP1
		SwitchGear 3'UTR luciferase reporter plasmid: AEBP1 3' UTR sequence

Inhib. RNA Products:		Browse for Gene Knock-down Tools from EMD Millipore
		OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for AEBP1 (see all 7) OriGene shRNA RFP: AEBP1 OriGene siRNA: AEBP1
		QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat AEBP1

Gene Editing
Products:

DNA2.0 Custom Protein Engineering Service for AEBP1

Clone Products:		Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
		OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for AEBP1 (see all 3) OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for AEBP1 OriGene custom cloning services � gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
		GenScript: all cDNA clones in your preferred vector: AEBP1 (NM_001129)
		Browse Sino Biological Human cDNA Clones
		DNA2.0 Custom Codon Optimized Gene Synthesis Service for AEBP1
		Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat AEBP1

Cell Line Products:		GenScript Custom overexpressing Cell Line Services for AEBP1
		Search LifeMap BioReagents cell lines for AEBP1

In Situ Assay
Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for AEBP1

Gene Ontology (GO): 5/7 molecular function terms (GO ID links to tree view) (see all 7): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0003677	DNA binding	IEA	--
GO:0003700	sequence-specific DNA binding transcription factor activity	TAS	8920928
GO:0003714	transcription corepressor activity	IEA	--
GO:0004180	carboxypeptidase activity	TAS	8920928
GO:0004181	metallocarboxypeptidase activity	IEA	--

AEBP1 for ontologies About GeneDecksing

1 GenomeRNAi human phenotype for AEBP1:

Increased G1 DNA content

Animal Models:
Mouse knock-outs for AEBP1: Aebp1^tm1Mdl Aebp1^tm1Hsro
11 MGI mutant phenotypes (inferred from 2 alleles) (MGI details for Aebp1):

adipose tissue	behavior/neurological	cellular	digestive/alimentary	endocrine/exocrine gland
growth/size	homeostasis/metabolism	integument	limbs/digits/tail	liver/biliary system
mortality/aging

AEBP1 for phenotypes About GeneDecksing

(Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to ¹UniProtKB, ²MINT, ³I2D, and/or ⁴STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
About This Section

Interactions:

Search SABiosciences Gene Network Central^TM Interacting Genes and Proteins Networks for AEBP1

STRING Interaction Network Preview (showing 2 interactants - click image to see more details)

5/7 Interacting proteins for AEBP1 (Q8IUX7^{2, 3} ENSP00000223357⁴) via UniProtKB, MINT, STRING, and/or I2D (see all 7)

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
TCF3	P15923³, ENSP00000262965⁴	I2D: score=2 STRING: ENSP00000262965
GRB2	P62993³, ENSP00000339007⁴	I2D: score=1 STRING: ENSP00000339007
PLCG1	P19174³	I2D: score=2
PTK2	Q05397³	I2D: score=2
GMEB2	Q9UKD1³	I2D: score=1

About this table

Gene Ontology (GO): 5/6 biological process terms (GO ID links to tree view) (see all 6): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0001501	skeletal system development	TAS	8920928
GO:0006351	transcription, DNA-dependent	IEA	--
GO:0006355	regulation of transcription, DNA-dependent	--	--
GO:0006508	proteolysis	IEA	--
GO:0007155	cell adhesion	IEA	--

AEBP1 for ontologies About GeneDecksing

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
About This Section

AEBP1 for compounds About GeneDecksing

Browse Small Molecules at EMD Millipore

Browse drugs & compounds from Enzo Life Sciences

Browse Tocris compounds for AEBP1
1 Novoseek chemical compound relationship for AEBP1 gene About this table

Compound	-log (P-Val)	Hits	PubMed IDs for Articles with Shared Sentences (# sentences)
zinc	7.39	3	2017183 (2), 11161801 (1)

Search CenterWatch for drugs/clinical trials and news about AEBP1

(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from EMD Millipore,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
About This Section

REFSEQ mRNAs for AEBP1 gene:

NM_001129.3

Unigene Cluster for AEBP1:

AE binding protein 1

Hs.439463 [show with all ESTs]

Unigene Representative Sequence: NM_001129

9 Ensembl transcripts including schematic representations, and UCSC links where relevant:

ENST00000223357(uc003tkb.3) ENST00000455443 ENST00000449162 ENST00000453052

ENST00000454218 ENST00000434445 ENST00000450684(uc003tkc.4) ENST00000413907(uc003tkd.3)

ENST00000431035

miRNA Products:		OriGene 3'-UTR Clone: AEBP1 Browse OriGene MicroRNA Expression Plasmids
		QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat AEBP1
		Search QIAGEN for miScript miRNA Assays for microRNAs that regulate AEBP1
		SwitchGear 3'UTR luciferase reporter plasmid: AEBP1 3' UTR sequence

Inhib. RNA Products:		Browse for Gene Knock-down Tools from EMD Millipore
		OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for AEBP1 (see all 7) OriGene shRNA RFP: AEBP1 OriGene siRNA: AEBP1
		QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat AEBP1

Clone Products:		OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for AEBP1 (see all 3) OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for AEBP1 OriGene custom cloning services � gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
		GenScript: all cDNA clones in your preferred vector: AEBP1 (NM_001129)
		DNA2.0 Custom Codon Optimized Gene Synthesis Service for AEBP1
		Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat AEBP1

Primer Products:		OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for AEBP1 Browse OriGene validated miRNA SYBR primer pairs
		SABiosciences RT² qPCR Primer Assay in human, mouse, rat AEBP1
		QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat AEBP1
		QIAGEN QuantiFast Probe-based Assays in human, mouse, rat AEBP1

Additional cDNA sequence:

AB209744.1 AF053944.1 AK090931.1 AK127541.1 AK296001.1 BC038588.1 D86479.1

19 DOTS entries:

DT.416578 DT.97788359 DT.100663759 DT.91991375 DT.95253095 DT.100663761 DT.121045041 DT.121044993

DT.100663769 DT.91775044 DT.121044991 DT.121044999 DT.92021856 DT.95128411 DT.97799728 DT.99981427

DT.121044979 DT.40224206 DT.95105014

24/308 AceView cDNA sequences (see all 308):

CA393424 BF724960 AW057582 BQ015344 AI914522 AA595306 BQ884305 CF125153

BX476531 BQ231970 CD514819 AA993064 BF968191 BX952471 BU617371 BU150688

BF341089 BP349662 BQ708481 CB268388 BM672693 BQ668395 AI300224 AW471279

GeneLoc Exon Structure

5/17 Alternative Splicing Database (ASD) splice patterns (SP) for AEBP1 (see all 17) About this scheme

ExUns:	1	^	2	^	3a	·	3b	^	4	^	5a	·	5b	^	6a	·	6b	^	7	^	8a	·	8b	·	8c	^	9a	·	9b	^	10	^	11	^	12a	·	12b	·	12c	·	12d	·	12e	^	13a	·	13b	·	13c	^	14a	·
SP1:																																			-		-		-
SP2:																	-																		-		-		-
SP3:
SP4:
SP5:																	-								-		-								-		-		-

ExUns:	14b	^	15a	·	15b	·	15c	^	16a	·	16b	·	16c	^	17a	·	17b	·	17c	^	18a	·	18b	^	19a	·	19b	·	19c	^	20	^	21	^	22	^	23
SP1:			-														-		-
SP2:
SP3:																	-		-
SP4:																			-						-
SP5:

ECgene alternative splicing isoforms for AEBP1

(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section

AEBP1 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: ACTGGGACCT

About this image

AEBP1 expression in embryonic tissues and stem cells

Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine About this table

3 LifeMap In Vivo Development Anatomical Compartments/Cells

Tissue

Anatomical Compartment

Cell

Category (developmental path)

Endothelium

Veins

Vascular Smooth Muscle Cells

Smooth Muscle

Heart

Aortic Arch Arteries

Vascular Smooth Muscle Cells

Myocardium, Neural Crest, Smooth Muscle

Heart

Endocardium

Vascular Smooth Muscle Cells

Smooth Muscle

Expression:

Positive

Negative

Selective marker

Experimental details:

Curated

Microarrays

In-situ hybridization

Stem Cell Differentiation: 8 LifeMap Cells

Name

Category

PureStem™ epithelial progenitor E164 (Embryonic Progenitor Cell)

Intermediate Mesoderm, Kidney

PureStem™ progenitor E68 (Embryonic Progenitor Cell)

PureStem™ mesenchymal Progenitor SK11 (Embryonic Progenitor Cell)

Adipose, Bone, Cartilage

PureStem™ mesenchymal progenitor 7SMOO32 (Embryonic Progenitor Cell)

Adipose, Bone, Cartilage

PureStem™ mesenchymal progenitor E15 (Embryonic Progenitor Cell)

Adipose, Bone, Cartilage

Blimp1- mVenus and stella-ECFP genetically modified stem cells (Embryonic Stem Cell)

Early Embryo, Inner Cell Mass

Paraxial mesoderm-derived smooth muscle cells (Generation of human ...)

Lateral plate mesoderm-derived smooth muscle cells (Generation of human ...)

See AEBP1 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for AEBP1

SOURCE GeneReport for Unigene cluster: Hs.439463

UniProtKB/Swiss-Prot: AEBP1_HUMAN, Q8IUX7

Tissue specificity: Expressed in osteoblast and visceral fat

SABiosciences Expression via Pathway-Focused PCR Array including AEBP1:

Insulin Signaling Pathway in human mouse rat

Primer Products:		OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for AEBP1 Browse OriGene validated miRNA SYBR primer pairs
		SABiosciences RT² qPCR Primer Assay in human, mouse, rat AEBP1
		QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat AEBP1
		QIAGEN QuantiFast Probe-based Assays in human, mouse, rat AEBP1

In Situ
Assay Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for AEBP1

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD , ⁵MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or ⁶Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
About This Section

This gene was present in the common ancestor of eukaryotes.

Orthologs for AEBP1 gene from 5/20 species (see all 20) About this table

Organism	Taxonomic classification	Gene	Description	Human Similarity	Orthology Type	Details
lizard (Anolis carolinensis)	Reptilia	AEBP1⁶ --	--	54(a) 37(a)	1 ↔ 1 possible ortholog	GL343238.1(289247-317274) AAWZ02040490(2225-6619)
zebrafish (Danio rerio)	Actinopterygii	LOC793308¹	adipocyte enhancer-binding protein 1-like	58.55(n) 54.34(a)		793308 XM_001920851.2 XP_001920886.1
fruit fly (Drosophila melanogaster)	Insecta	svr⁶	silver	12(a)	possible ortholog	X(390504-403113)
thale cress (Arabidopsis thaliana)	eudicotyledons	SOL1⁶	putative carboxypeptidase D	24(a)	1 → many	1(26966887-26970572)
rice (Oryza sativa)	Liliopsida	--	zinc carboxypeptidase family protein, putative, ex...	27(a)	1 → many	6(2357309-2364541)

ENSEMBL Gene Tree for AEBP1 (if available)
TreeFam Gene Tree for AEBP1 (if available)

(Paralogs according to ¹HomoloGene,
²Ensembl, and ³SIMAP, Pseudogenes according to ⁴Pseudogene.org Build 68)
About This Section

Paralogs for AEBP1 gene

CPZ² CPE² CPXM2² CPN1² CPD² CPM² CPXM1²

4 SIMAP similar genes for AEBP1 using alignment to 7 protein entries: AEBP1_HUMAN (see all proteins):

DKFZp666J235 CPXM1 CPXM2 CPE

AEBP1 for paralogs About GeneDecksing

(SNPs/Variants according to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section

SNP ID	Valid	Clinical significance	Chr 7 pos	Sequence	#	AA Chg	Type	More	#	Allele freq	Pop	Total sample	More
Genomic Data					Transcription Related Data				Allele Frequencies
				--	--	--		--	--
rs76051387^1,2	F,	--	44142034(+)	`GTGACG/ATGCCA`	1	--	us2k¹		1		WA	118
rs188680146^1,2		--	44142068(+)	`CCGCCA/GGGCTT`	1	--	us2k¹		0	--	--	--	--
rs143070947^1,2		--	44142085(+)	`CTCAAC/TTGGGG`	1	--	us2k¹		0	--	--	--	--
rs117746577^1,2		--	44142094(+)	`GGCAAC/TGGAGC`	1	--	us2k¹		1		NA	120
rs148212893^1,2		--	44142304(+)	`GATCTC/TTGAGG`	1	--	us2k¹		0	--	--	--	--
rs140213132^1,2		--	44142346(+)	`GAGTGC/TCAAGA`	1	--	us2k¹		0	--	--	--	--
rs181792560^1,2		--	44142381(+)	`ATGATA/CCTGTA`	1	--	us2k¹		0	--	--	--	--
rs150235047^1,2		--	44142526(+)	`CAGGGG/TCTTGG`	1	--	us2k¹		0	--	--	--	--
rs186961268^1,2		--	44142763(+)	`TTCCCC/TACCTG`	1	--	us2k¹		0	--	--	--	--
rs2014453^1,2	C,F,O,A,H,	--	44142792(-)	`TCTGCG/AGGGTT`	1	--	us2k¹		20		MN NS EA NA WA	4012

HapMap Linkage Disequilibrium report for AEBP1 (44143960 - 44154161 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 2 variations for AEBP1
2 CNVs: 4532 31342

SABiosciences Cancer Mutation PCR Assays

Search QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing AEBP1

DNA2.0 Custom Variant and Variant Library Synthesis for AEBP1

(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
About This Section

AEBP1 for disorders           About GeneDecksing

OMIM gene information: 602981    OMIM disorders: --

4 diseases for AEBP1:    About MalaCards

gastroschisis immunodeficiency fibrosis cholesterol

1 disease from the University of Copenhagen DISEASES database for AEBP1:

Gastroschisis

3 Novoseek disease relationships for AEBP1 gene About this table

Disease	-log (P-Val)	Hits	PubMed IDs for Articles with Shared Sentences (# sentences)
inflammation	25	6	16461908 (1), 20396415 (1), 20419060 (1)
immunodeficiency	11	3	2022670 (1), 11161801 (1), 2302185 (1)
cancer	0	1	17202411 (1)

Export disorders for AEBP1 gene to outside databases

(in PubMed. Associations of this gene to articles via ¹Entrez Gene, ²UniProtKB/Swiss-Prot, ³HGNC, ⁴GAD, ⁵PharmGKB, ⁶HMDB, ⁷DrugBank, ⁸UniProtKB/TrEMBL, ⁹ Novoseek, and/or ¹⁰fRNAdb)
About This Section

PubMed articles for AEBP1 gene, integrated from 9 sources (see all 34):
(articles sorted by number of sources associating them with AEBP1)

Utopia: connect your pdf to the dynamic
world of online information

A cDNA cloning of human AEBP1 from primary cultured osteoblasts and its expression in a differentiating osteoblastic cell line. (PubMed id 8920928)^{1, 2, 3, 9} Ohno I....Okubo K. (1996)
Aortic carboxypeptidase-like protein, a novel protein with discoidin and carboxypeptidase-like domains, is up-regulated during vascular smooth muscle cell differentiation. (PubMed id 9624159)^{1, 2, 9} Layne M.D.... Lee M.-E. (1998)
Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)^{1, 2} Ota T.... Sugano S. (2004)
Human chromosome 7: DNA sequence and biology. (PubMed id 12690205)^{1, 2} Scherer S.W.... Tsui L.-C. (2003)
Aortic carboxypeptidase-like protein is expressed in fibrotic human lung and its absence protects against bleomycin-induced lung fibrosis. (PubMed id 19179605)^{1, 9} Schissel S.L....Layne M.D. (2009)
PPARgamma1 and LXRalpha face a new regulator of macro phage cholesterol homeostasis and inflammatory responsiveness, AEBP1. (PubMed id 20419060)^{1, 9} Majdalawieh A. and Ro H.S. (2010)
Enzymic characterization of a novel member of the regulatory B-like carboxypeptidase with transcriptional repression function: stimulation of enzymic activity by its target DNA. (PubMed id 10510298)^{1, 9} Muise A.M. and Ro H.S. (1999)
Glycoproteomics analysis of human liver tissue by combination of multiple enzyme digestion and hydrazide chemistry. (PubMed id 19159218)² Chen R.... Zou H. (2009)
Protein interaction data set highlighted with human Ras-MAPK/PI3K signaling pathways. (PubMed id 18624398)¹ Wang J....He F. (2008)
The role of AEBP1 in sex-specific diet-induced obesit y. (PubMed id 16307171)¹ Zhang L....Ro H.S. (2005)

(in PubMed, OMIM, and NCBI Bookshelf)
About This Section

		AND	OR
Aliases
Disorders
Free Text

Query String		PubMed OMIM NCBI Bookshelf
	(Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
About This Section

Entrez Gene: 165	HGNC: 303	AceView: AEBP1	Ensembl:ENSG00000106624	euGenes: HUgn165
ECgene: AEBP1	H-InvDB: AEBP1

(According to HUGE)
About This Section

(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section

Name	Description
PharmGKB entry for AEBP1	Pharmacogenomics, SNPs, Pathways

Intellectual Property for AEBP1 gene
(Patent information from GeneIP, Licensable technologies from WIS Yeda, Salk, Tufts, IP news from LifeMap Sciences, Inc.)

About This Section

Patent Information for AEBP1 gene:
Search GeneIP for patents involving AEBP1

GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search

(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences),
In Situ Hybridization Assays from
Advanced Cell Diagnostics
About This Section


	EMD Millipore Custom Antibody & Bulk Services
	EMD Millipore Preclinical / Clinical Development Services
	EMD Millipore Immunoassay Services
	EMD Millipore Target Screening & Profiling Services

	Antibodies for AEBP1 (ACLP)		Browse Cell Culture Products
	Browse ELISAs		Browse Flow Cytometry Kits
	Browse Primer Pairs		Browse Kinase Activity Assays/Reagents
	Browse ELISpot Kits/Development Modules		Browse TFB/Immunoprecipitation Assays
	Browse Apoptosis Detection Kits/Reagents		Browse Ubiquitin Proteasome Pathway (UPP) Assay Kits/Reagents
	Browse DNA Damage/Repair Kits/Reagents		Browse Multiplex/Array Assay Kits/Reagents
	Browse Cell Selection/Detection Kits/Reagents		Browse Secondary Antibodies/Controls/Staining Reagents
	Browse Phosphatase Activity Assays/Reagents		Browse Recombinant/Natural Proteins

	Browse OriGene Antibodies		OriGene shRNA RFP for AEBP1
	OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for AEBP1		OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for AEBP1
	Browse OriGene Protein Over-expression Lysates		Browse OriGene Fluorogenic Cell Assay Kits
	OriGene siRNA for AEBP1		OriGene 3'-UTR Clone for AEBP1
	OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for AEBP1		OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for AEBP1
	Browse OriGene GFP tagged cDNA clones in CMV expression vector		Browse OriGene MicroRNA Expression Plasmids
	Browse OriGene basic RS shRNAs		Browse OriGene validated miRNA SYBR primer pairs
	Browse OriGene full length recombinant human proteins expressed in human HEK293 cells		OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
	OriGene Custom Antibody Services for AEBP1		OriGene Custom Protein Services for AEBP1
	OriGene Custom Immunoassay Development

	QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat AEBP1
	Search QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing AEBP1
	QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat AEBP1
	QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat AEBP1
	QIAGEN QuantiFast Probe-based Assays in human, mouse, rat AEBP1
	QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat AEBP1

	GenScript Custom Purified and Recombinant Proteins Services for AEBP1		GenScript cDNA clones with any tag delivered in your preferred vector for AEBP1
	GenScript Custom Assay Services for AEBP1		GenScript Custom Superior Antibodies Services for AEBP1
	GenScript Custom overexpressing Cell Line Services for AEBP1		CloneReady with Over 120,000 Genes
	Gene Synthesis: Any Gene in Any Vector		Vector-based siRNA and miRNA, Ready for Transfection
	Gene Mutant Library, Variants up to 10^11		Plasmid Preparation
	Custom Peptide Services

Search for Antibodies & Assays

	Regulatory tfbs in AEBP1 promoter
	Search Chromatin IP Primers for AEBP1
	RT² qPCR Primer Assay in human, mouse, rat AEBP1
	Search GNC Networks for AEBP1
	SABiosciences PCR Arrays including human, mouse, rat AEBP1

Search Tocris compounds for AEBP1

	Browse Sino Biological Proteins and Antibodies
	Browse Sino Biological cDNA Clones
	Antibodies/Proteins Production Services
	Rabbit Monoclonal Antibody Platform
	Bulk Purchasing

Search www.enzolifesciences.com for proteins, assays, substrates, inhibitors & antibodies

	Novus Tissue Slides
	AEBP1 antibodies
	AEBP1 proteins

	Search for Antibodies for AEBP1 at Abcam
	See all of Abcam's Antibodies, Kits and Proteins for AEBP1
	Custom Antibody / Protein Production Service
	Bulk Purchasing
	Advantages of Rabbit Monoclonal antibodies
	Abcam protocols and scientific support

Browse ProSpec Recombinant Proteins

AEBP1 Proteins, Antibodies, CLIAs, and ELISAs

Search LifeMap BioReagents cell lines for AEBP1

	Gene Synthesis
	Protein Engineering
	Variant Library Synthesis
	Codon Optimization
	Protein Production and Purification

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for AEBP1

	SwitchGear 3'UTR luciferase reporter plasmids for AEBP1
	SwitchGear Promoter luciferase reporter plasmids for AEBP1

ThermoFisher Antibodies for AEBP1

Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat AEBP1

GeneCards Homepage - Last full update: 18 Mar 2013 - Incrementals: 21 Mar 2013 , 15 Apr 2013 , 26 Apr 2013

View Random Gene

Category			VWF (GIFTS: 73) von Willebrand factor
GIFtS Group

The GeneCards human gene database gene index: 1 3 5 6 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

The GeneCards Human Gene Database

Developed at the Crown Human Genome Center, Department of Molecular Genetics, the Weizmann Institute of Science

Hot genes Disease genes AEBP1 gene at Home site.

hostname: 356980-web2.xennexinc.com index build: 100 solr: 1.4

Advanced Search

Export list of displayed genes

AEBP1 Gene

AE binding protein 1

Aliases
for AEBP1 gene

Summaries
for AEBP1 gene

Genomic Views
for AEBP1 gene

Proteins
for AEBP1 gene

Protein Domains /
Families
for AEBP1 gene

Function
for AEBP1 gene

Pathways & Interactions
for AEBP1 gene

Drugs & Compounds
for AEBP1 gene

Transcripts
for AEBP1 gene

Expression
for AEBP1 gene

Orthologs
for AEBP1 gene

Paralogs
for AEBP1 gene

Genomic Variants
for AEBP1 gene

Disorders / Diseases
for AEBP1 gene

Publications
for AEBP1 gene

External Searches for AEBP1 gene

Genome Databases showing AEBP1 gene

Other Databases showing AEBP1 gene

Specialized Databases showing AEBP1 gene

Intellectual Property
for AEBP1 gene

Products
for AEBP1 gene

View Random Gene

Advanced Search

Export list of displayed genes

AEBP1 Gene

AE binding protein 1

Aliasesfor AEBP1 gene

Summariesfor AEBP1 gene

Genomic Viewsfor AEBP1 gene

Proteinsfor AEBP1 gene

Protein Domains /Familiesfor AEBP1 gene

Functionfor AEBP1 gene

Pathways & Interactionsfor AEBP1 gene

Drugs & Compoundsfor AEBP1 gene

Transcriptsfor AEBP1 gene

Expression for AEBP1 gene

Orthologsfor AEBP1 gene

Paralogsfor AEBP1 gene

Genomic Variantsfor AEBP1 gene

Disorders / Diseasesfor AEBP1 gene

Publicationsfor AEBP1 gene

External Searches for AEBP1 gene

Genome Databases showing AEBP1 gene

Other Databases showing AEBP1 gene

Specialized Databases showing AEBP1 gene

Intellectual Propertyfor AEBP1 gene

Productsfor AEBP1 gene

View Random Gene

Aliases
for AEBP1 gene

Summaries
for AEBP1 gene

Genomic Views
for AEBP1 gene

Proteins
for AEBP1 gene

Protein Domains /
Families
for AEBP1 gene

Function
for AEBP1 gene

Pathways & Interactions
for AEBP1 gene

Drugs & Compounds
for AEBP1 gene

Transcripts
for AEBP1 gene

Expression
for AEBP1 gene

Orthologs
for AEBP1 gene

Paralogs
for AEBP1 gene

Genomic Variants
for AEBP1 gene

Disorders / Diseases
for AEBP1 gene

Publications
for AEBP1 gene

Intellectual Property
for AEBP1 gene

Products
for AEBP1 gene