Set Analyses:
Advanced Search

Advanced Search

 
Search By
Section (entire)
for


 
or upload a file of gene symbols


Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

AEBP1 Gene

protein-coding   GIFtS: 56
GCID: GC07P044143

AE Binding Protein 1

(Previous name: AE-binding protein 1)
  See related disease
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
AE Binding Protein 11 2
Aortic Carboxypeptidase-Like Protein1 2 3
AE-Binding Protein 11 3
ACLP2 3
Adipocyte Enhancer Binding Protein 11
Adipocyte Enhancer-Binding Protein 12

External Ids:    HGNC: 3031   Entrez Gene: 1652   Ensembl: ENSG000001066247   OMIM: 6029815   UniProtKB: Q8IUX73   

Export aliases for AEBP1 gene to outside databases

Previous GC identifers: GC07P043790 GC07P043850 GC07P043884 GC07P043917 GC07P044110 GC07P044029


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for AEBP1 Gene:
This gene encodes a member of carboxypeptidase A protein family. The encoded protein may function as a
transcriptional repressor and play a role in adipogenesis and smooth muscle cell differentiation. Studies in mice
suggest that this gene functions in wound healing and abdominal wall development. Overexpression of this gene is
associated with glioblastoma. (provided by RefSeq, May 2013)

GeneCards Summary for AEBP1 Gene: 
AEBP1 (AE binding protein 1) is a protein-coding gene. Diseases associated with AEBP1 include gastroschisis. GO annotations related to this gene include calmodulin binding and sequence-specific DNA binding transcription factor activity. An important paralog of this gene is CPZ.

UniProtKB/Swiss-Prot: AEBP1_HUMAN, Q8IUX7
Function: May positively regulate MAP-kinase activity in adipocytes, leading to enhanced adipocyte proliferation
and reduced adipocyte differentiation (By similarity). May also positively regulate NF-kappa-B activity in
macrophages by promoting the phosphorylation and subsequent degradation of I-kappa-B-alpha (NFKBIA), leading to
enhanced macrophage inflammatory responsiveness (By similarity). Can act as a transcriptional repressor (By
similarity)




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000007.13  NC_018918.2  NT_007819.17  NT_079592.2  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the AEBP1 gene promoter:
         AREB6   SRF   PPAR-gamma1   Sp1   SRF (504 AA)   Olf-1   PPAR-gamma2   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmids (see all 9): AEBP1 promoter sequence
   Search SABiosciences Chromatin IP Primers for AEBP1

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat AEBP1


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 7p13   Ensembl cytogenetic band:  7p13   HGNC cytogenetic band: 7p

AEBP1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
AEBP1 gene location

GeneLoc information about chromosome 7         GeneLoc Exon Structure

GeneLoc location for GC07P044143:  view genomic region     (about GC identifiers)

Start:
44,143,960 bp from pter      End:
44,154,161 bp from pter
Size:
10,202 bases      Orientation:
plus strand

1 alternative location:
Chr7+,CRA_TCAG 44,183,452-44,193,654     

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: AEBP1_HUMAN, Q8IUX7 (See protein sequence)
Recommended Name: Adipocyte enhancer-binding protein 1 precursor  
Size: 1158 amino acids; 130929 Da
Subunit: Interacts with GNG5, NFKBIA, MAPK1, MAPK3 and PTEN (By similarity). May interact with calmodulin (By
similarity). Binds to DNA in vitro (By similarity)
Subcellular location: Isoform 1: Secreted (By similarity)
Subcellular location: Isoform 2: Cytoplasm (Probable). Nucleus (Probable)
Caution: Although related to peptidase M14 family, lacks the active sites residues and zinc-binding sites,
suggesting that it has no carboxypeptidase activity
Sequence caution: Sequence=BAD92981.1; Type=Erroneous initiation;
Secondary accessions: Q14113 Q59ER7 Q6ZSC7 Q7KZ79
Alternative splicing: 2 isoforms:  Q8IUX7-1   Q8IUX7-2   (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for AEBP1: NX_Q8IUX7

Explore proteomics data for AEBP1 at MOPED 

Post-translational modifications:

  • UniProtKB: Phosphorylated by MAPK1 in vitro (By similarity)
  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_Q8IUX7

  • AEBP1 Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    AEBP1 Protein Expression
    REFSEQ proteins: NP_001120.3  
    ENSEMBL proteins: 
     ENSP00000223357   ENSP00000411277   ENSP00000401758   ENSP00000400660   ENSP00000397241  
     ENSP00000398878   ENSP00000410349   ENSP00000416568  

    Human Recombinant Protein Products for AEBP1: 
    Browse Purified and Recombinant Proteins at EMD Millipore
    Browse R&D Systems for human recombinant proteins
    Browse recombinant and purified proteins available from Enzo Life Sciences
    Browse OriGene full length recombinant human proteins expressed in human HEK293 cells
    Browse OriGene Protein Over-expression Lysates
    OriGene Custom MassSpec 
    OriGene Custom Protein Services for AEBP1
    GenScript Custom Purified and Recombinant Proteins Services for AEBP1
    Novus Biologicals AEBP1 Protein
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates 
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for AEBP1 

    Gene Ontology (GO): 4 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005615extracellular space IDA--
    GO:0005634nucleus IEA--
    GO:0005737cytoplasm IEA--
    GO:0031012colocalizes with extracellular matrix IDA--

    AEBP1 for ontologies           About GeneDecksing



    AEBP1 Antibody Products: 
    Browse EMD Millipore's Extensive Line of Mono- and Polyclonal Antibodies
    R&D Systems Antibodies for AEBP1 (ACLP)
    Browse OriGene Antibodies
    OriGene Custom Antibody Services for AEBP1
    GenScript Custom Superior Antibodies Services for AEBP1
    Novus Biologicals AEBP1 Antibodies
    Search for Antibodies for AEBP1 at Abcam
    Cloud-Clone Corp. Antibodies for AEBP1 
    ThermoFisher Antibodies for AEBP1
    LSBio Antibodies in human, mouse, rat for AEBP1 

    Assay Products for AEBP1: 
    Browse Kits and Assays available from EMD Millipore
    OriGene Custom Assay Services for AEBP1
    Browse R&D Systems for biochemical assays
    GenScript Custom Assay Services for AEBP1
    Browse Enzo Life Sciences for kits & assays
    Cloud-Clone Corp. ELISAs for AEBP1 
    Cloud-Clone Corp. CLIAs for AEBP1


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    IUPHAR Guide to PHARMACOLOGY protein family classification: AE binding protein 1 
    Metallocarboxypeptidases

    5 InterPro protein domains:
     IPR000834 Peptidase_M14
     IPR000421 Coagulation_fac_5/8-C_type_dom
     IPR008969 CarboxyPept-like_regulatory
     IPR014766 CarboxyPept_regulatory_dom
     IPR008979 Galactose-bd-like

    Graphical View of Domain Structure for InterPro Entry Q8IUX7

    ProtoNet protein and cluster: Q8IUX7

    1 Blocks protein domain: IPB000421 Coagulation factor 5/8 type C domain (FA58C)

    UniProtKB/Swiss-Prot: AEBP1_HUMAN, Q8IUX7
    Similarity: Belongs to the peptidase M14 family
    Similarity: Contains 1 F5/8 type C domain


    AEBP1 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: AEBP1_HUMAN, Q8IUX7
    Function: May positively regulate MAP-kinase activity in adipocytes, leading to enhanced adipocyte proliferation
    and reduced adipocyte differentiation (By similarity). May also positively regulate NF-kappa-B activity in
    macrophages by promoting the phosphorylation and subsequent degradation of I-kappa-B-alpha (NFKBIA), leading to
    enhanced macrophage inflammatory responsiveness (By similarity). Can act as a transcriptional repressor (By
    similarity)

         Gene Ontology (GO): 5/7 molecular function terms (GO ID links to tree view) (see all 7):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003677DNA binding IEA--
    GO:0003700sequence-specific DNA binding transcription factor activity TAS8920928
    GO:0003714transcription corepressor activity IEA--
    GO:0004180carboxypeptidase activity TAS8920928
    GO:0004181metallocarboxypeptidase activity IEA--
         
    AEBP1 for ontologies           About GeneDecksing


    Phenotypes:
         1 GenomeRNAi human phenotype for AEBP1:
     Increased G1 DNA content 

         11 MGI mutant phenotypes (inferred from 2 alleles(MGI details for Aebp1):
     adipose tissue  behavior/neurological  cellular  digestive/alimentary  endocrine/exocrine gland 
     growth/size  homeostasis/metabolism  integument  limbs/digits/tail  liver/biliary system 
     mortality/aging 

    AEBP1 for phenotypes           About GeneDecksing

    Animal Models:
         MGI mouse knock-outs for AEBP1: Aebp1tm1Mdl Aebp1tm1Hsro

       inGenious Targeting Laboratory - Custom generated mouse model solutions for AEBP1 
       inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for AEBP1

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for AEBP1 
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for AEBP1 

    miRNA
    Products:
        
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat AEBP1
    Search QIAGEN for miScript miRNA Assays for microRNAs that regulate AEBP1
    SwitchGear 3'UTR luciferase reporter plasmidAEBP1 3' UTR sequence
    Inhib. RNA
    Products:
        
    Browse for Gene Knock-down Tools from EMD Millipore
    OriGene RNAi products in human, mouse, rat for AEBP1
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat AEBP1

    Gene Editing
    Products:
    DNA2.0 Custom Protein Engineering Service for AEBP1
    Sirion Biotech Customized adenovirus for overexpression of AEBP1

    Clone
    Products:
         
    Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
    OriGene clones in human, mouse for AEBP1 (see all 7)
    OriGene ORF clones in mouse, rat for AEBP1
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: AEBP1 (NM_001129)
    Sino Biological Human cDNA Clone for AEBP1
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for AEBP1
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat AEBP1
    Sirion Biotech Customized lentivirus for stable overexpression of AEBP1 
                         Customized lentivirus expression plasmids for stable overexpression of AEBP1 

    Cell Line
    Products:
         
    GenScript Custom overexpressing Cell Line Services for AEBP1
    Search LifeMap BioReagents cell lines for AEBP1
    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for AEBP1


    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section




    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for AEBP1

    STRING Interaction Network Preview (showing 2 interactants - click image to see more details)

    5/7 Interacting proteins for AEBP1 (Q8IUX72, 3 ENSP000002233574) via UniProtKB, MINT, STRING, and/or I2D (see all 7)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    TCF3P159233, ENSP000002629654I2D: score=2 STRING: ENSP00000262965
    GRB2P629933, ENSP000003390074I2D: score=1 STRING: ENSP00000339007
    PLCG1P191743I2D: score=2 
    PTK2Q053973I2D: score=2 
    GMEB2Q9UKD13I2D: score=1 
    About this table

    Gene Ontology (GO): 5/6 biological process terms (GO ID links to tree view) (see all 6):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0001501skeletal system development TAS8920928
    GO:0006351transcription, DNA-dependent IEA--
    GO:0006355regulation of transcription, DNA-dependent ----
    GO:0006508proteolysis IEA--
    GO:0007155cell adhesion IEA--

    AEBP1 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section

    AEBP1 for compounds           About GeneDecksing

    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for AEBP1

    1 Novoseek inferred chemical compound relationship for AEBP1 gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    zinc 7.39 3 2017183 (2), 11161801 (1)

    Search CenterWatch for drugs/clinical trials and news about AEBP1

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for AEBP1 gene: 
    NM_001129.4  

    Unigene Cluster for AEBP1:

    AE binding protein 1
    Hs.439463  [show with all ESTs]
    Unigene Representative Sequence: NM_001129
    9 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000223357(uc003tkb.3) ENST00000455443 ENST00000449162 ENST00000453052
    ENST00000454218 ENST00000434445 ENST00000450684(uc003tkc.4) ENST00000413907(uc003tkd.3)
    ENST00000431035
    miRNA
    Products:
         
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat AEBP1
    Search QIAGEN for miScript miRNA Assays for microRNAs that regulate AEBP1
    SwitchGear 3'UTR luciferase reporter plasmidAEBP1 3' UTR sequence
    Inhib. RNA
    Products:
         
    Browse for Gene Knock-down Tools from EMD Millipore
    OriGene RNAi products in human, mouse, rat for AEBP1
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat AEBP1
    Clone
    Products:
         
    OriGene clones in human, mouse for AEBP1 (see all 7)
    OriGene ORF clones in mouse, rat for AEBP1
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: AEBP1 (NM_001129)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for AEBP1
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat AEBP1
    Sirion Biotech Customized lentivirus for stable overexpression of AEBP1 
                         Customized lentivirus expression plasmids for stable overexpression of AEBP1 
    Primer
    Products:
        
    OriGene qSTAR qPCR primer pairs in human, mouse for AEBP1
    SABiosciences RT2 qPCR Primer Assay in human, mouse, rat AEBP1
      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat AEBP1
      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat AEBP1

    Additional mRNA sequence: 

    AB209744.1 AF053944.1 AK090931.1 AK127541.1 AK296001.1 BC038588.1 D86479.1 

    19 DOTS entries:

    DT.416578  DT.97788359  DT.100663759  DT.91991375  DT.95253095  DT.100663761  DT.121045041  DT.121044993 
    DT.100663769  DT.91775044  DT.121044991  DT.121044999  DT.92021856  DT.95128411  DT.97799728  DT.99981427 
    DT.121044979  DT.40224206  DT.95105014 

    24/308 AceView cDNA sequences (see all 308):

    CB268388 AI300224 AW057582 BQ708481 CN482343 AA993064 AA976886 BU627634 
    BX476531 BM672693 CA393708 BQ182647 BU617371 BQ183397 BQ668395 AL602749 
    CF125153 BQ897584 AL040503 BC038588 AA283179 BF344552 BQ181860 BM663409 

    GeneLoc Exon Structure

    5/17 Alternative Splicing Database (ASD) splice patterns (SP) for AEBP1 (see all 17)    About this scheme

    ExUns: 1 ^ 2 ^ 3a · 3b ^ 4 ^ 5a · 5b ^ 6a · 6b ^ 7 ^ 8a · 8b · 8c ^ 9a · 9b ^ 10 ^ 11 ^ 12a · 12b · 12c · 12d · 12e ^ 13a · 13b · 13c ^ 14a ·
    SP1:                                                                                                        -     -     -                                       
    SP2:                                                  -                                                     -     -     -                                       
    SP3:                                                                                                                                                            
    SP4:                                                                                                                                                            
    SP5:                                                  -                       -     -                       -     -     -                                       

    ExUns: 14b ^ 15a · 15b · 15c ^ 16a · 16b · 16c ^ 17a · 17b · 17c ^ 18a · 18b ^ 19a · 19b · 19c ^ 20 ^ 21 ^ 22 ^ 23
    SP1:        -                                         -     -                                                         
    SP2:                                                                                                                  
    SP3:                                                  -     -                                                         
    SP4:                                                        -                 -                                       
    SP5:                                                                                                                  


    ECgene alternative splicing isoforms for AEBP1

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    AEBP1 expression in normal human tissues (normalized intensities)      AEBP1 embryonic expression: see
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: ACTGGGACCT
    AEBP1 Expression
    About this image


    AEBP1 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database 
     5/21 selected tissues (see all 21) fully expand
     
     Heart (Cardiovascular System)    fully expand to see all 6 entries
             Vascular Smooth Muscle Cells Aortic Arch Arteries
             Coronary Vessels
             heart/ventricle   
     
     Lateral Plate Mesoderm (Gastrulation Derivatives)    fully expand to see all 3 entries
             Vascular Smooth Muscle Cells Splanchnic Mesoderm
             PureStem ES-209, Meso-prx/latp Progenitor
             skeleton/axial skeleton   
     
     Smooth Muscle (Muscoskeletal System)    fully expand to see all 3 entries
             Vascular Smooth Muscle Cells Aortic Arch Arteries
     
     Mesoderm (Gastrulation Derivatives)    fully expand to see all 2 entries
             PureStem 7SMOO32, NCr-fac & Meso Progenitor
             skeleton/axial skeleton   
     
     Paraxial Mesoderm (Gastrulation Derivatives)    fully expand to see all 2 entries
             PureStem ES-209, Meso-prx/latp Progenitor
             skeleton/axial skeleton   

    See AEBP1 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for AEBP1

    SOURCE GeneReport for Unigene cluster: Hs.439463

    UniProtKB/Swiss-Prot: AEBP1_HUMAN, Q8IUX7
    Tissue specificity: Expressed in osteoblast and visceral fat

        SABiosciences Expression via Pathway-Focused PCR Array including AEBP1: 
              Insulin Signaling Pathway in human mouse rat

    Primer
    Products:
    OriGene qSTAR qPCR primer pairs in human, mouse for AEBP1
    SABiosciences RT2 qPCR Primer Assay in human, mouse, rat AEBP1
    QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat AEBP1
    QIAGEN QuantiFast Probe-based Assays in human, mouse, rat AEBP1
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for AEBP1

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of chordates.

    Orthologs for AEBP1 gene from 4/12 species (see all 12)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Aebp11 , 5 AE binding protein 11, 5 83.93(n)1
    85.5(a)1
      11 (3.88 cM)5
    115681  NM_009636.21  NP_033766.21 
     58619475 
    chicken
    (Gallus gallus)
    Aves AEBP16
    AE binding protein 1
    73(a)
    1 ↔ 1
    JH376336.1(21-3018)
    lizard
    (Anolis carolinensis)
    Reptilia AEBP16
    AE binding protein 1
    64(a)
    1 ↔ 1
    GL343238.1(289023-321884)
    zebrafish
    (Danio rerio)
    Actinopterygii LOC7933081 adipocyte enhancer-binding protein 1-like 58.55(n)
    54.34(a)
      793308  XM_001920851.2  XP_001920886.1 


    ENSEMBL Gene Tree for AEBP1 (if available)
    TreeFam Gene Tree for AEBP1 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for AEBP1 gene
    CPZ2  CPE2  CPXM22  CPN12  CPD2  CPM2  CPXM12  
    4 SIMAP similar genes for AEBP1 using alignment to 7 protein entries:     AEBP1_HUMAN (see all proteins):
    DKFZp666J235    CPXM1    CPXM2    CPE

    AEBP1 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/274 SNPs in AEBP1 are shown (see all 274)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 7 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1436053771,2
    Cuntested144153268(+) CACCCC/TGAGCG 2 P L mis11Minor allele frequency- T:0.00NA 4548
    VAR_0431224
    ----see VAR_0431222 V I mis40--------
    VAR_0431214
    ----see VAR_0431212 K E mis40--------
    rs760513871,2
    C,F--44142034(+) GTGACG/ATGCCA 1 -- us2k11Minor allele frequency- A:0.03WA 118
    rs1886801461,2
    --44142068(+) CCGCCA/GGGCTT 1 -- us2k10--------
    rs1430709471,2
    C--44142085(+) CTCAAC/TTGGGG 1 -- us2k10--------
    rs1177465771,2
    C,F--44142094(+) GGCAAC/TGGAGC 1 -- us2k11Minor allele frequency- T:0.01NA 120
    rs1482128931,2
    --44142304(+) GATCTC/TTGAGG 1 -- us2k10--------
    rs1402131321,2
    --44142346(+) GAGTGC/TCAAGA 1 -- us2k10--------
    rs1817925601,2
    --44142381(+) ATGATA/CCTGTA 1 -- us2k10--------

    HapMap Linkage Disequilibrium report for AEBP1 (44143960 - 44154161 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 6 variations for AEBP1:    About this table     
    Variant IDTypeSubtypePubMed ID
    nsv887996CNV Loss21882294
    nsv887997CNV Loss21882294
    nsv470210CNV Loss18288195
    nsv830983CNV Loss17160897
    nsv428165CNV Gain18775914
    nsv8082CNV Gain18304495

    SABiosciences Cancer Mutation PCR Assays
    Search QIAGEN SeqTarget long-range PCR primers for resequencing AEBP1
    DNA2.0 Custom Variant and Variant Library Synthesis for AEBP1

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    OMIM gene information: 602981    OMIM disorders: --

    2 diseases for AEBP1:    About MalaCards
    gastroschisis    

    1 disease from the University of Copenhagen DISEASES database for AEBP1:
    Gastroschisis

    AEBP1 for disorders           About GeneDecksing

    3 Novoseek inferred disease relationships for AEBP1 gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    inflammation 25 6 16461908 (1), 20396415 (1), 20419060 (1)
    immunodeficiency 11 3 2022670 (1), 11161801 (1), 2302185 (1)
    cancer 0 1 17202411 (1)


    Export disorders for AEBP1 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for AEBP1 gene, integrated from 9 sources (see all 40):
    (articles sorted by number of sources associating them with AEBP1)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. A cDNA cloning of human AEBP1 from primary cultured osteoblasts and its expression in a differentiating osteoblastic cell line. (PubMed id 8920928)1, 2, 3, 9 Ohno I....Okubo K. (1996)
    2. Aortic carboxypeptidase-like protein, a novel protein with discoidin and carboxypeptidase-like domains, is up-regulated during vascular smooth muscle cell differentiation. (PubMed id 9624159)1, 2, 9 Layne M.D.... Lee M.-E. (1998)
    3. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (2004)
    4. Human chromosome 7: DNA sequence and biology. (PubMed id 12690205)1, 2 Scherer S.W.... Tsui L.-C. (2003)
    5. Aortic carboxypeptidase-like protein is expressed in fibrotic human lung and its absence protects against bleomycin-induced lung fibrosis. (PubMed id 19179605)1, 9 Schissel S.L....Layne M.D. (2009)
    6. Regulation of IkappaBalpha function and NF-kappaB sig naling: AEBP1 is a novel proinflammatory mediator in macrophages. (PubMed id 20396415)1, 9 Majdalawieh A. and Ro H.S. (2010)
    7. PPARgamma1 and LXRalpha face a new regulator of macro phage cholesterol homeostasis and inflammatory responsiveness, AEBP1. (PubMed id 20419060)1, 9 Majdalawieh A. and Ro H.S. (2010)
    8. Enzymic characterization of a novel member of the regulatory B-like carboxypeptidase with transcriptional repression function: stimulation of enzymic activity by its target DNA. (PubMed id 10510298)1, 9 Muise A.M. and Ro H.S. (1999)
    9. AEBP1 gene variants in infants with gastroschisis. (PubMed id 22821744)1 Feldkamp M.L....Botto L.D. (2012)
    10. Berberine-induced inhibition of adipocyte enhancer-bin ding protein 1 attenuates oxidized low-density lipoprotein accumulation and foam cell formation in phorbol 12-myristate 13-acetate-induced macrophages. (PubMed id 22796454)1 Huang Z....Huang W. (2012)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 165 HGNC: 303 AceView: AEBP1 Ensembl:ENSG00000106624 euGenes: HUgn165
    ECgene: AEBP1 H-InvDB: AEBP1

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for AEBP1 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for AEBP1 gene:
    Search GeneIP for patents involving AEBP1

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0 and Sirion Biotech, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Sirion Biotech, Cell lines from GenScript, and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
    About This Section

     
     EMD Millipore Custom Antibody & Bulk Services
     EMD Millipore Preclinical / Clinical Development Services
     EMD Millipore Immunoassay Services
     EMD Millipore Target Screening & Profiling Services

      
     Antibodies for AEBP1 (ACLP)   Browse Cell Culture Products  
     Browse ELISAs   Browse Flow Cytometry Kits  
     Browse Primer Pairs   Browse Kinase Activity Assays/Reagents  
     Browse ELISpot Kits/Development Modules   Browse TFB/Immunoprecipitation Assays  
     Browse Apoptosis Detection Kits/Reagents   Browse Ubiquitin Proteasome Pathway (UPP) Assay Kits/Reagents  
     Browse DNA Damage/Repair Kits/Reagents   Browse Multiplex/Array Assay Kits/Reagents  
     Browse Cell Selection/Detection Kits/Reagents   Browse Secondary Antibodies/Controls/Staining Reagents  
     Browse Protease Activity Assays and Reagents   Browse Recombinant/Natural Proteins  
     Browse Stem Cell Products   Browse Tocris Biochemicals & Compounds  
     Browse cDNA Clones   Browse Proteome Profiler Antibody Arrays  
     Browse OriGene Antibodies   OriGene RNAi products in human, mouse, rat for AEBP1  
     Browse OriGene qPCR primer pairs and template standards   Browse OriGene Protein Over-expression Lysates  
     OriGene Custom Mass Spec   OriGene clones in human, mouse for AEBP1  
     OriGene qSTAR qPCR primer pairs in human, mouse for AEBP1   Browse OriGene full length recombinant human proteins expressed in human HEK293 cells  
     OriGene ORF clones in mouse, rat for AEBP1   OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling  
     OriGene Custom Antibody Services for AEBP1   OriGene Custom Protein Services for AEBP1  

     
     
     QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat AEBP1
     QIAGEN SeqTarget long-range PCR primers for resequencing AEBP1
     QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat AEBP1
     QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat AEBP1
     QIAGEN QuantiFast Probe-based Assays in human, mouse, rat AEBP1
     QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat AEBP1
     GenScript Custom Purified and Recombinant Proteins Services for AEBP1 GenScript cDNA clones with any tag delivered in your preferred vector for AEBP1
     GenScript Custom Assay Services for AEBP1 GenScript Custom Superior Antibodies Services for AEBP1
     GenScript Custom overexpressing Cell Line Services for AEBP1 CloneReady with Over 120,000 Genes
     Gene Synthesis: Any Gene in Any Vector Vector-based siRNA and miRNA, Ready for Transfection
     Gene Mutant Library, Variants up to 10^11 Plasmid Preparation
     Custom Peptide Services
     Search for Antibodies & Assays

     Regulatory tfbs in AEBP1 promoter
     Search Chromatin IP Primers for AEBP1
     RT2 qPCR Primer Assay in human, mouse, rat AEBP1
     Search GNC Networks for AEBP1
     SABiosciences PCR Arrays including human, mouse, rat AEBP1
     Search Tocris compounds for AEBP1
     Browse Sino Biological Proteins and Antibodies
     Browse Sino Biological Cell Lysates
     cDNA Clones for AEBP1
     4000+ Proteins
     Search Sino Biological for antibodies, proteins & pathways
     Protein Production Services
     Transfection Reagents
     Protein A/G/L resins
     Isotyping reagents
     Search www.enzolifesciences.com for proteins, assays, substrates, inhibitors & antibodies
     Novus Tissue Slides
     AEBP1 antibodies
     AEBP1 proteins
     Search for Antibodies for AEBP1 at Abcam
     See all of Abcam's Antibodies, Kits and Proteins for AEBP1
     Custom Antibody / Protein Production Service
     Bulk Purchasing
     Advantages of Rabbit Monoclonal antibodies
     Abcam protocols and scientific support
     Browse ProSpec Recombinant Proteins




     Proteins for AEBP1
     Antibodies for AEBP1
     ELISAs for AEBP1
     CLIAs for AEBP1
     Search LifeMap BioReagents cell lines for AEBP1
     Gene Synthesis
     Protein Engineering
     Variant Library Synthesis
     Codon Optimization
     Protein Production and Purification
     Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for AEBP1
     SwitchGear 3'UTR luciferase reporter plasmids for AEBP1
     SwitchGear Promoter luciferase reporter plasmids for AEBP1
     ThermoFisher Antibodies for AEBP1
     Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat AEBP1
     inGenious Targeting Laboratory - Custom generated mouse model solutions for AEBP1
     inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for AEBP1
    Customized:
     lentivirus for stable overexpression of AEBP1
     lentivirus expression plasmids for stable overexpression of AEBP1
     adenovirus for overexpression of AEBP1
     LSBio Antibodies in human, mouse, rat for AEBP1
    Customized transgenic rodents for:
     Humanization
     Biomarker expression
     Off-target effect monitoring
     Translational medicine
     Tissue-specific gene expresssion
     Time-controlled gene expresssion
           
    GeneCards Homepage - Last full update: 23 Oct 2013 - Incrementals: 4 Nov 2013 , 7 Nov 2013 , 23 Jan 2014

    View Random Gene

    Category
    (GIFtS: 73)
    transforming growth factor, beta 1
    GIFtS Group
    The GeneCards human gene database gene index: 1 3 5 6 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z 


    Developed at the Crown Human Genome Center, Department of Molecular Genetics, the Weizmann Institute of Science

    Hot genes      Disease genes      AEBP1 gene at Home site.
    hostname: 356977-web1.xennexinc.com index build: 106 solr: 1.4