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Aliases for AEBP1 Gene

Aliases for AEBP1 Gene

  • AE Binding Protein 1 2 3
  • Aortic Carboxypeptidase-Like Protein 2 3 4
  • AE-Binding Protein 1 2 4
  • ACLP 3 4
  • Adipocyte Enhancer Binding Protein 1 2
  • Adipocyte Enhancer-Binding Protein 1 3

External Ids for AEBP1 Gene

Previous GeneCards Identifiers for AEBP1 Gene

  • GC07P043790
  • GC07P043850
  • GC07P043884
  • GC07P043917
  • GC07P044110
  • GC07P044143
  • GC07P044029

Summaries for AEBP1 Gene

Entrez Gene Summary for AEBP1 Gene

  • This gene encodes a member of carboxypeptidase A protein family. The encoded protein may function as a transcriptional repressor and play a role in adipogenesis and smooth muscle cell differentiation. Studies in mice suggest that this gene functions in wound healing and abdominal wall development. Overexpression of this gene is associated with glioblastoma. [provided by RefSeq, May 2013]

GeneCards Summary for AEBP1 Gene

AEBP1 (AE Binding Protein 1) is a Protein Coding gene. Diseases associated with AEBP1 include gastroschisis and glioblastoma. GO annotations related to this gene include sequence-specific DNA binding transcription factor activity and calmodulin binding. An important paralog of this gene is CPN1.

UniProtKB/Swiss-Prot for AEBP1 Gene

  • May positively regulate MAP-kinase activity in adipocytes, leading to enhanced adipocyte proliferation and reduced adipocyte differentiation. May also positively regulate NF-kappa-B activity in macrophages by promoting the phosphorylation and subsequent degradation of I-kappa-B-alpha (NFKBIA), leading to enhanced macrophage inflammatory responsiveness. Can act as a transcriptional repressor.

No data available for Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for AEBP1 Gene

Genomics for AEBP1 Gene

Regulatory Elements for AEBP1 Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for AEBP1 Gene

Start:
44,104,361 bp from pter
End:
44,114,565 bp from pter
Size:
10,205 bases
Orientation:
Plus strand

Genomic View for AEBP1 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for AEBP1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for AEBP1 Gene

Proteins for AEBP1 Gene

  • Protein details for AEBP1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8IUX7-AEBP1_HUMAN
    Recommended name:
    Adipocyte enhancer-binding protein 1
    Protein Accession:
    Q8IUX7
    Secondary Accessions:
    • Q14113
    • Q59ER7
    • Q6ZSC7
    • Q7KZ79

    Protein attributes for AEBP1 Gene

    Size:
    1158 amino acids
    Molecular mass:
    130929 Da
    Quaternary structure:
    • Interacts with GNG5, NFKBIA, MAPK1, MAPK3 and PTEN. May interact with calmodulin. Binds to DNA in vitro.
    SequenceCaution:
    • Sequence=BAD92981.1; Type=Erroneous initiation; Evidence={ECO:0000305};

    Alternative splice isoforms for AEBP1 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for AEBP1 Gene

Proteomics data for AEBP1 Gene at MOPED

Post-translational modifications for AEBP1 Gene

No data available for DME Specific Peptides for AEBP1 Gene

Domains for AEBP1 Gene

Gene Families for AEBP1 Gene

Suggested Antigen Peptide Sequences for AEBP1 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q8IUX7

UniProtKB/Swiss-Prot:

AEBP1_HUMAN :
  • Q8IUX7
Domain:
  • Contains 1 F5/8 type C domain.
Family:
  • Belongs to the peptidase M14 family.
genes like me logo Genes that share domains with AEBP1: view

Function for AEBP1 Gene

Molecular function for AEBP1 Gene

UniProtKB/Swiss-Prot Function: May positively regulate MAP-kinase activity in adipocytes, leading to enhanced adipocyte proliferation and reduced adipocyte differentiation. May also positively regulate NF-kappa-B activity in macrophages by promoting the phosphorylation and subsequent degradation of I-kappa-B-alpha (NFKBIA), leading to enhanced macrophage inflammatory responsiveness. Can act as a transcriptional repressor.

Gene Ontology (GO) - Molecular Function for AEBP1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000977 RNA polymerase II regulatory region sequence-specific DNA binding IDA 15654748
GO:0001227 RNA polymerase II transcription regulatory region sequence-specific DNA binding transcription factor activity involved in negative regulation of transcription IMP 15654748
GO:0003700 sequence-specific DNA binding transcription factor activity TAS 8920928
GO:0003714 transcription corepressor activity IEA --
GO:0004180 carboxypeptidase activity TAS 8920928
genes like me logo Genes that share ontologies with AEBP1: view
genes like me logo Genes that share phenotypes with AEBP1: view

Animal Models for AEBP1 Gene

MGI Knock Outs for AEBP1:

Animal Model Products

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for AEBP1

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , miRNA , Transcription Factor Targeting and HOMER Transcription for AEBP1 Gene

Localization for AEBP1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for AEBP1 Gene

Isoform 1: Secreted.
Isoform 2: Cytoplasm. Nucleus.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for AEBP1 Gene COMPARTMENTS Subcellular localization image for AEBP1 gene
Compartment Confidence
extracellular 4
nucleus 4
endoplasmic reticulum 2
golgi apparatus 2

Gene Ontology (GO) - Cellular Components for AEBP1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005615 extracellular space IDA 20551380
GO:0005634 nucleus IEA --
GO:0005737 cytoplasm IEA --
GO:0031012 colocalizes_with extracellular matrix IDA 20551380
GO:0070062 extracellular exosome IDA 19199708
genes like me logo Genes that share ontologies with AEBP1: view

Pathways for AEBP1 Gene

SuperPathways for AEBP1 Gene

No Data Available

PCR Array Products

  • Pathway & Disease-focused RT² Profiler PCR Arrays

Interacting Proteins for AEBP1 Gene

Gene Ontology (GO) - Biological Process for AEBP1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000122 negative regulation of transcription from RNA polymerase II promoter IMP 15654748
GO:0001501 skeletal system development TAS 8920928
GO:0006351 transcription, DNA-templated IEA --
GO:0006355 regulation of transcription, DNA-templated --
GO:0006508 proteolysis IEA --
genes like me logo Genes that share ontologies with AEBP1: view

No data available for Pathways by source for AEBP1 Gene

Compounds for AEBP1 Gene

(1) Novoseek inferred chemical compound relationships for AEBP1 Gene

Compound -log(P) Hits PubMed IDs
zinc 7.39 3
genes like me logo Genes that share compounds with AEBP1: view

Transcripts for AEBP1 Gene

Unigene Clusters for AEBP1 Gene

AE binding protein 1:
Representative Sequences:

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for AEBP1

Primer Products

  • OriGene qSTAR qPCR primer pairs in human,mouse,rat for AEBP1

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for AEBP1 Gene

ExUns: 1 ^ 2 ^ 3a · 3b ^ 4 ^ 5a · 5b ^ 6a · 6b ^ 7 ^ 8a · 8b · 8c ^ 9a · 9b ^ 10 ^ 11 ^ 12a · 12b · 12c · 12d · 12e ^ 13a · 13b · 13c ^ 14a ·
SP1: - - -
SP2: - - - -
SP3:
SP4:
SP5: - - - - - -
SP6: -
SP7: - - -
SP8: - - -
SP9: - - - - -
SP10:
SP11:
SP12: - - -
SP13: -
SP14:
SP15:
SP16: -
SP17:

ExUns: 14b ^ 15a · 15b · 15c ^ 16a · 16b · 16c ^ 17a · 17b · 17c ^ 18a · 18b ^ 19a · 19b · 19c ^ 20 ^ 21 ^ 22 ^ 23
SP1: - - -
SP2:
SP3: - -
SP4: - -
SP5:
SP6:
SP7:
SP8: - -
SP9:
SP10: - -
SP11:
SP12:
SP13:
SP14:
SP15:
SP16:
SP17:

Relevant External Links for AEBP1 Gene

GeneLoc Exon Structure for
AEBP1
ECgene alternative splicing isoforms for
AEBP1

Expression for AEBP1 Gene

mRNA expression in normal human tissues for AEBP1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for AEBP1 Gene

This gene is overexpressed in Artery - Aorta (8.7), Artery - Coronary (6.6), and Artery - Tibial (5.5).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for AEBP1 Gene

SOURCE GeneReport for Unigene cluster for AEBP1 Gene Hs.439463

mRNA Expression by UniProt/SwissProt for AEBP1 Gene

Q8IUX7-AEBP1_HUMAN
Tissue specificity: Expressed in osteoblast and visceral fat.
genes like me logo Genes that share expressions with AEBP1: view

In Situ Assay Products

Orthologs for AEBP1 Gene

This gene was present in the common ancestor of chordates.

Orthologs for AEBP1 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia AEBP1 35
  • 99.48 (n)
  • 99.31 (a)
AEBP1 36
  • 99 (a)
OneToOne
cow
(Bos Taurus)
Mammalia AEBP1 35
  • 84.79 (n)
  • 86.61 (a)
AEBP1 36
  • 85 (a)
OneToOne
dog
(Canis familiaris)
Mammalia AEBP1 35
  • 89.48 (n)
  • 94.43 (a)
AEBP1 36
  • 83 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Aebp1 35
  • 83.36 (n)
  • 84.75 (a)
Aebp1 16
Aebp1 36
  • 85 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia AEBP1 36
  • 78 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia AEBP1 36
  • 74 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Aebp1 35
  • 83.41 (n)
  • 85.4 (a)
chicken
(Gallus gallus)
Aves AEBP1 36
  • 74 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia AEBP1 36
  • 65 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia aebp1 35
  • 62.44 (n)
  • 61.45 (a)
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.2504 35
zebrafish
(Danio rerio)
Actinopterygii aebp1 36
  • 49 (a)
OneToMany
AEBP1 (1 of 2) 36
  • 37 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 38 (a)
OneToMany
Species with no ortholog for AEBP1:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for AEBP1 Gene

ENSEMBL:
Gene Tree for AEBP1 (if available)
TreeFam:
Gene Tree for AEBP1 (if available)

Paralogs for AEBP1 Gene

Paralogs for AEBP1 Gene

Selected SIMAP similar genes for AEBP1 Gene using alignment to 7 proteins:

genes like me logo Genes that share paralogs with AEBP1: view

Variants for AEBP1 Gene

Sequence variations from dbSNP and Humsavar for AEBP1 Gene

SNP ID Clin Chr 07 pos Sequence Context AA Info Type MAF
VAR_043118 -
VAR_043119 -
VAR_043120 -
VAR_043121 -
VAR_043122 -

Structural Variations from Database of Genomic Variants (DGV) for AEBP1 Gene

Variant ID Type Subtype PubMed ID
nsv428165 CNV Gain 18775914
nsv8082 CNV Gain 18304495
nsv887996 CNV Loss 21882294
nsv470210 CNV Loss 18288195
nsv830983 CNV Loss 17160897
nsv887997 CNV Loss 21882294

Relevant External Links for AEBP1 Gene

HapMap Linkage Disequilibrium report
AEBP1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for AEBP1 Gene

Disorders for AEBP1 Gene

MalaCards: The human disease database

MalaCards: The human disease database. (2) Diseases for AEBP1 Gene including...

Search for AEBP1 Gene in MalaCards »

(1) University of Copenhagen DISEASES for AEBP1 Gene

(3) Novoseek inferred disease relationships for AEBP1 Gene

Disease -log(P) Hits PubMed IDs
inflammation 25 3
immunodeficiency 11 3
cancer 0 1
genes like me logo Genes that share disorders with AEBP1: view

No data available for UniProtKB/Swiss-Prot for AEBP1 Gene

Publications for AEBP1 Gene

  1. A cDNA cloning of human AEBP1 from primary cultured osteoblasts and its expression in a differentiating osteoblastic cell line. (PMID: 8920928) Ohno I. … Okubo K. (Biochem. Biophys. Res. Commun. 1996) 2 3 4 23
  2. Aortic carboxypeptidase-like protein, a novel protein with discoidin and carboxypeptidase-like domains, is up-regulated during vascular smooth muscle cell differentiation. (PMID: 9624159) Layne M.D. … Lee M.-E. (J. Biol. Chem. 1998) 3 4 23
  3. Enzymic characterization of a novel member of the regulatory B-like carboxypeptidase with transcriptional repression function: stimulation of enzymic activity by its target DNA. (PMID: 10510298) Muise A.M. … Ro H.S. (Biochem. J. 1999) 3 23
  4. MAPK modulates the DNA binding of adipocyte enhancer-binding protein 1. (PMID: 15654748) Lyons P.J. … Ro H.S. (Biochemistry 2005) 3 23
  5. Human chromosome 7: DNA sequence and biology. (PMID: 12690205) Scherer S.W. … Tsui L.-C. (Science 2003) 3 4

Products for AEBP1 Gene

Sources for AEBP1 Gene

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