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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

ADTRP Gene

protein-coding   GIFtS: 43
GCID: GC06M011712

androgen-dependent TFPI-regulating protein

(Previous name: chromosome 6 open reading frame 105 )
(Previous symbol: C6orf105)
  Search for ADTRP
in
MalaCards
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 Human Malady Compendium 
Biological research products
for ADTRP    

Aliases
for ADTRP gene

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, and/or 10fRNAdb)
About This Section
Aliases
Androgen-Dependent TFPI-Regulating Protein1 2
C6orf1051 2 3
AIG1L1 2
DJ413H6.11
Chromosome 6 Open Reading Frame 1051
Androgen-Dependent TPF1-Regulating Protein2

External Ids:    HGNC: 212141   Entrez Gene: 848302   Ensembl: ENSG000001118637   OMIM: 6143485   UniProtKB: Q96IZ23   

Export aliases for ADTRP gene to outside databases


Summaries
for ADTRP gene

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section
UniProtKB/Swiss-Prot: ADTRP_HUMAN, Q96IZ2
Function: Regulates the expression and the cell-associated anticoagulant activity of the inhibitor TFPI in endothelial
cells (in vitro)




Genomic Views
for ADTRP gene

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000006.11  NC_018917.1  NT_007592.15  
Regulatory elements:
   Search SABiosciences Regulatory transcription factor binding sites for ADTRP
         Other transcription factors

Browse SwitchGear Promoter luciferase reporter plasmids
   Search SABiosciences Chromatin IP Primers for ADTRP

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat ADTRP


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 6p24.1   Ensembl cytogenetic band:  6p24.1   HGNC cytogenetic band: 6p24.1

ADTRP Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
ADTRP gene location

GeneLoc information about chromosome 6         GeneLoc Exon Structure

GeneLoc location for GC06M011712:  view genomic region     (about GC identifiers)

Start:
 11,712,287 bp from pter      End:
 11,807,279 bp from pter
Size:
 94,993 bases      Orientation:
 minus strand

Proteins
for ADTRP gene

(According to 1UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to 2PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section
UniProtKB/Swiss-Prot: ADTRP_HUMAN, Q96IZ2 (See protein sequence)
Recommended Name: Androgen-dependent TFPI-regulating protein  
Size: 230 amino acids; 26842 Da
Subcellular location: Cell membrane; Multi-pass membrane protein. Note=Colocalized with TFPI and CAV1 in lipid rafts
Secondary accessions: B2R7T9 B4DV39 Q5THW1
Alternative splicing: 3 isoforms:  Q96IZ2-1   Q96IZ2-2   Q96IZ2-3   (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for ADTRP: NX_Q96IZ2

Post-translational modifications:

  • View modification sites using PhosphoSitePlus2
  • View neXtProt modification sites for NX_Q96IZ2

    • ADTRP Protein expression data from MOPED and PaxDb:    About this image 
    Estimated protein expression log10 (pmol).

    REFSEQ proteins (2 alternative transcripts): 
    NP_001137420.1  NP_116133.1  

    ENSEMBL proteins: 
     ENSP00000424680   ENSP00000404416   ENSP00000229583   ENSP00000426507   ENSP00000368726  
     ENSP00000422927   ENSP00000420956   ENSP00000368723  

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    OriGene Protein Over-expression Lysate: ADTRP
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    Novus Biologicals ADTRP Lysate
    Browse Sino Biological Recombinant Proteins
    Browse ProSpec Recombinant Proteins
    Uscn Proteins for ADTRP

    Gene Ontology (GO): 2 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005886plasma membrane IEA--
    GO:0016021integral to membrane IEA--


    ADTRP for ontologies           About GeneDecksing



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    Uscn ELISAs and CLIAs for ADTRP

    Protein Domains /
    Families
    for ADTRP gene

    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    ADTRP for domains           About GeneDecksing

    1 InterPro domain/family:
     IPR006838 Far-17a_AIG1

    Graphical View of Domain Structure for InterPro Entry Q96IZ2

    ProtoNet protein and cluster: Q96IZ2

    UniProtKB/Swiss-Prot: ADTRP_HUMAN, Q96IZ2
    Similarity: Belongs to the AIG1 family


    Function
    for ADTRP gene

    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
    About This Section
    Function Summary:

         UniProtKB/Swiss-Prot: ADTRP_HUMAN, Q96IZ2
    Function: Regulates the expression and the cell-associated anticoagulant activity of the inhibitor TFPI in endothelial
    cells (in vitro)
    Induction: By androgens

    miRNA
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    Inhib. RNA
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    OriGene siRNA: ADTRP
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    Gene Editing
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    Clone
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    In Situ Assay
    Products:       
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    1 GenomeRNAi human phenotype for ADTRP:
     Low eccentricity cells 


    Pathways & Interactions
    for ADTRP gene

    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
    About This Section



    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for ADTRP

    STRING Interaction Network Preview (showing 1 interactants - click image to see more details)

    3 Interacting proteins for ADTRP (Q96IZ23 ENSP000004044164) via UniProtKB, MINT, STRING, and/or I2D
    InteractantInteraction Details
    GeneCardExternal ID(s)
    CREB3O438893I2D: score=1 
    S100BP042713I2D: score=1 
    VTNENSP000002262184STRING: ENSP00000226218
    About this table

    Drugs & Compounds
    for ADTRP gene

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for ADTRP
    Search CenterWatch for drugs/clinical trials and news about ADTRP 

    Transcripts
    for ADTRP gene

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section
    REFSEQ mRNAs for ADTRP gene (2 alternative transcripts): 
    NM_001143948.1  NM_032744.3  

    Unigene Cluster for ADTRP:

    Androgen-dependent TFPI-regulating protein
    Hs.126409  [show with all ESTs]
    Unigene Representative Sequence: AK123258
    11 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000505099 ENST00000414691(uc011dip.2 uc003nab.3) ENST00000514824(uc003naa.3)
    ENST00000513651 ENST00000512139 ENST00000229583 ENST00000503285 ENST00000379415
    ENST00000506810 ENST00000485323 ENST00000379413

    miRNA
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    SwitchGear 3'UTR luciferase reporter plasmid: ADTRP 3' UTR sequence
    Inhib. RNA
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    OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for ADTRP (see all 4)
    OriGene shRNA RFP: ADTRP
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    Clone
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    Primer
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    Additional cDNA sequence: 

    AJ420520.1 AK123258.1 AK300919.1 AK310611.1 AK313114.1 BC007011.1 

    7 DOTS entries:

    DT.107414  DT.121365752  DT.40128440  DT.91754499  DT.99931085  DT.100020897  DT.40119004 

    24/50 AceView cDNA sequences (see all 50):

    AI147084 BF475842 AA772671 CA448374 BX103449 BM710493 BG740489 BM922289 
    BX360750 AI652898 BG741725 AI656760 AI478124 CB048095 AW130198 BC007011 
    AA156064 BG696998 BM994936 AK123258 AA659733 BI459991 BM819622 AI336841 

    GeneLoc Exon Structure

    5/6 Alternative Splicing Database (ASD) splice patterns (SP) for ADTRP (see all 6)    About this scheme

    ExUns: 1 ^ 2a · 2b ^ 3 ^ 4a · 4b ^ 5 ^ 6a · 6b ^ 7 ^ 8 ^ 9a · 9b ^ 10
    SP1:                                                        -                 -         
    SP2:                                      -                 -           -     -         
    SP3:        -                                                                           
    SP4:                                                        -                           
    SP5:                                                                    -     -         


    ECgene alternative splicing isoforms for ADTRP

    Expression
    for ADTRP gene

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    ADTRP expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS
    CGAP TAG: --

    Microarray
    RNAseq (Illumina Body Map)
    (100×FPKM)½
    SAGE (Serial Analysis of Gene Expression)
    About this image

    ADTRP expression in embryonic tissues and stem cells
    Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine    About this table
    2 LifeMap In Vivo Development Anatomical Compartments/Cells 
    Tissue Anatomical Compartment CellCategory (developmental path)
    AdiposeInterscapular Brown Adipose DepotAdipose
    AdiposeThoracic Perivascular AdiposeAdipose
    Expression: Positive    Negative     Selective marker
    Experimental details: Curated     Microarrays     In-situ hybridization
    Stem Cell Differentiation: 3 LifeMap Cells 
    NameCategory
    Human umbilical vein endothelial cells (HUVEC) (Primary Cell)Endothelium
    PureStem™ endothelial progenitor 30-SM2-1 (Embryonic Progenitor Cell)Endothelium
    PureStem™ progenitor E44 (Embryonic Progenitor Cell)

    See ADTRP Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for ADTRP

    SOURCE GeneReport for Unigene cluster: Hs.126409

    UniProtKB/Swiss-Prot: ADTRP_HUMAN, Q96IZ2
    Tissue specificity: Expressed in cultured endothelial cells and in placenta

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    In Situ
    Assay Products:     
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    Orthologs
    for ADTRP gene

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section
    This gene was present in the common ancestor of animals.

    Orthologs for ADTRP gene from 5/19 species (see all 19)    About this table
    Organism Taxonomic
    classification    		 Gene Description Human
    Similarity    		 Orthology
    Type    		 Details
    chicken
    (Gallus gallus)    		 Aves C2H6orf1051 chromosome 2 open reading frame, human C6orf105 61.69(n)
    50.23(a)    		   771464  XM_001234746.1  XP_001234747.1 
    lizard
    (Anolis carolinensis)    		 Reptilia C6orf1056
    --
    		 --
    		 43(a)
    35(a)
    		 1 ↔ 1
    possible ortholog
    		 GL343209.1(3174608-3207810)
    GL343770.1(108993-118181)
    zebrafish
    (Danio rerio)    		 Actinopterygii zgc:1121751 zgc:112175 52.55(n)
    42.34(a)    		   550414  NM_001017719.1  NP_001017719.1 
    fruit fly
    (Drosophila melanogaster)    		 Insecta CG36256
    CG61496
    (see all 3)    		 --
    		 31(a)
    30(a)
    (see all 3)    		 many ↔ many
    many ↔ many
    (see all 3)    		 2L(283384-291751)
    3L(11427795-11428576)
    worm
    (Caenorhabditis elegans)    		 Secernentea C37E2.26
    C37E2.36
    		 Protein C37E2.3
    		 20(a)
    17(a)
    		 many ↔ many
    many ↔ many
    		 X(14175981-14178402)
    X(14178919-14181636)


    ENSEMBL Gene Tree for ADTRP (if available)
    TreeFam Gene Tree for ADTRP (if available) 

    Paralogs
    for ADTRP gene

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for ADTRP gene
    AIG12  
    1 SIMAP similar gene for ADTRP using alignment to 6 protein entries:     ADTRP_HUMAN (see all proteins):
    AIG1

    ADTRP for paralogs           About GeneDecksing



    Genomic Variants
    for ADTRP gene

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/1287 NCBI SNPs in ADTRP are shown (see all 1287)     About this table
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance    		Chr 6 posSequence#AA
    Chg    		TypeMore#Allele
    freq    		PopTotal
    sample    		More
    ----------
    rs1116812701,2
    		--11713525(+) GTCCTC/TTTCTG 2 -- int12Minor allele frequency- T:0.03CSA WA 120
    rs1485793961,2
    		--11713540(+) CCTTCA/TAGACC 2 -- int10--------
    rs174013891,2
    		C,F,--11713593(+) GTTGGG/TAAGTC 2 -- int13Minor allele frequency- T:0.01NA 140
    rs1464135071,2
    		--11713645(+) AGCCTA/GGTGAC 2 -- int10--------
    rs1915823431,2
    		--11713916(+) ACTATA/GCCATT 2 -- ut310--------
    rs1838835731,2
    		--11713917(+) CTATAA/CCATTT 2 -- ut310--------
    rs1879455021,2
    		--11714014(+) CAGAAA/GAGAAA 2 -- ut310--------
    rs1398785881,2
    		--11714129(+) TTTTAA/GATCAC 2 -- ut310--------
    rs1128346531,2
    		C,--11714183(+) GAAATG/TCTTGT 2 -- ut312Minor allele frequency- T:0.04CSA WA 120
    rs58743341,2
    		C,--11714194(+) TAAAG-/AAAAGT 2 -- ut311Minor allele frequency- A:0.50CSA 2

    HapMap Linkage Disequilibrium report for ADTRP (11712287 - 11807279 bp)
    Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
          Database of Genomic Variants (DGV) variations for ADTRP: --

    SABiosciences Cancer Mutation PCR Assays
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    DNA2.0 Custom Variant and Variant Library Synthesis for ADTRP

    Disorders / Diseases
    for ADTRP gene

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    ADTRP for disorders           About MalaCards

    ADTRP for disorders           About GeneDecksing

    OMIM gene information: 614348    OMIM disorders: --


    Export disorders for ADTRP gene to outside databases

    Publications
    for ADTRP gene

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for ADTRP gene integrated from 9 sources:
    (articles sorted by number of sources associating them with ADTRP)    		    Utopia: connect your pdf to the dynamic
    world of online information

    1. Novel protein ADTRP regulates TFPI expression and function in human endothelial cells in normal conditions and in response to androgen. (PubMed id 21868574)1, 2, 3 Lupu C.... Lupu F. (2011)
    2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    3. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (2004)
    4. The DNA sequence and analysis of human chromosome 6. (PubMed id 14574404)1, 2 Mungall A.J.... Beck S. (2003)
    5. Genome-wide association identifies a susceptibility l ocus for coronary artery disease in the Chinese Han population. (PubMed id 21378986)1 Wang F....Wang Q.K. (2011)
    6. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PubMed id 20379614)1 Rose J.E....Uhl G.R. (2010)
    7. High throughput SNP and expression analyses of candidate genes for non-syndromic oral clefts. (PubMed id 16415175)1 Park J.W....Beaty T.H. (2006)
    8. Sequence comparison of human and mouse genes reveals a homologous block structure in the promoter regions. (PubMed id 15342556)1 Suzuki Y.... Sugano S. (2004)
    9. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (2002)

    External Searches for ADTRP gene

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Free Text  
      Query String
    		PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    Genome Databases showing ADTRP gene

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 84830 HGNC: 21214 AceView: C6orf105 Ensembl:ENSG00000111863 euGenes: HUgn84830
    ECgene: ADTRP H-InvDB: ADTRP

    Other Databases showing ADTRP gene

    (According to HUGE)
    About This Section
    		   --

    Specialized Databases showing ADTRP gene

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for ADTRP Pharmacogenomics, SNPs, Pathways

    Intellectual Property
    for ADTRP gene

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    		Patent Information for ADTRP gene:
    Search GeneIP for patents involving ADTRP

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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    In Situ Hybridization Assays from
    Advanced Cell Diagnostics
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