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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

ADTRP Gene

protein-coding   GIFtS: 42
GCID: GC06M011712

Androgen-Dependent TFPI-Regulating Protein

(Previous name: chromosome 6 open reading frame 105)
(Previous symbol: C6orf105)
  See related disease
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
Androgen-Dependent TFPI-Regulating Protein1 2     AIG1L2
C6orf1051 2 3     Androgen-Dependent TPF1-Regulating Protein2
Androgen-Induced 1-Like1     dJ413H6.12
Chromosome 6 Open Reading Frame 1051     

External Ids:    HGNC: 212141   Entrez Gene: 848302   Ensembl: ENSG000001118637   OMIM: 6143485   UniProtKB: Q96IZ23   

Export aliases for ADTRP gene to outside databases


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

GeneCards Summary for ADTRP Gene: 
ADTRP (androgen-dependent TFPI-regulating protein) is a protein-coding gene. Diseases associated with ADTRP include endotheliitis. An important paralog of this gene is AIG1.

UniProtKB/Swiss-Prot: ADTRP_HUMAN, Q96IZ2
Function: Regulates the expression and the cell-associated anticoagulant activity of the inhibitor TFPI in
endothelial cells (in vitro)




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000006.11  NT_007592.15  NC_018917.2  
Regulatory elements:
   Search SABiosciences Regulatory transcription factor binding sites for ADTRP
         Other transcription factors

Browse SwitchGear Promoter luciferase reporter plasmids
   Search SABiosciences Chromatin IP Primers for ADTRP

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat ADTRP


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 6p24.1   Ensembl cytogenetic band:  6p24.1   HGNC cytogenetic band: 6p24.1

ADTRP Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
ADTRP gene location

GeneLoc information about chromosome 6         GeneLoc Exon Structure

GeneLoc location for GC06M011712:  view genomic region     (about GC identifiers)

Start:
11,712,287 bp from pter      End:
11,807,279 bp from pter
Size:
94,993 bases      Orientation:
minus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: ADTRP_HUMAN, Q96IZ2 (See protein sequence)
Recommended Name: Androgen-dependent TFPI-regulating protein  
Size: 230 amino acids; 26842 Da
Subcellular location: Cell membrane; Multi-pass membrane protein. Note=Colocalized with TFPI and CAV1 in lipid
rafts
Secondary accessions: B2R7T9 B4DV39 Q5THW1
Alternative splicing: 3 isoforms:  Q96IZ2-1   Q96IZ2-2   Q96IZ2-3   (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for ADTRP: NX_Q96IZ2

Explore proteomics data for ADTRP at MOPED 

Post-translational modifications:

  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_Q96IZ2

  • ADTRP Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    ADTRP Protein Expression
    REFSEQ proteins (2 alternative transcripts): 
    NP_001137420.1  NP_116133.1  

    ENSEMBL proteins: 
     ENSP00000424680   ENSP00000404416   ENSP00000229583   ENSP00000426507   ENSP00000368726  
     ENSP00000422927   ENSP00000420956   ENSP00000368723  

    Human Recombinant Protein Products for ADTRP: 
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    Novus Biologicals ADTRP Lysate
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates 
    Browse ProSpec Recombinant Proteins
    Browse Proteins at Cloud-Clone Corp. 

    Gene Ontology (GO): 2 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005886plasma membrane IEA--
    GO:0016021integral to membrane IEA--

    ADTRP for ontologies           About GeneDecksing



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    Browse CLIAs at Cloud-Clone Corp.


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    1 InterPro protein domain:
     IPR006838 Far-17a_AIG1

    Graphical View of Domain Structure for InterPro Entry Q96IZ2

    ProtoNet protein and cluster: Q96IZ2

    UniProtKB/Swiss-Prot: ADTRP_HUMAN, Q96IZ2
    Similarity: Belongs to the AIG1 family


    ADTRP for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: ADTRP_HUMAN, Q96IZ2
    Function: Regulates the expression and the cell-associated anticoagulant activity of the inhibitor TFPI in
    endothelial cells (in vitro)
    Induction: By androgens

    Phenotypes:
         1 GenomeRNAi human phenotype for ADTRP:

     Low eccentricity cells 

    Animal Models:
       inGenious Targeting Laboratory - Custom generated mouse model solutions for ADTRP 
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    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section



    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for ADTRP

    STRING Interaction Network Preview (showing 1 interactants - click image to see more details)

    3 Interacting proteins for ADTRP (Q96IZ23 ENSP000004044164) via UniProtKB, MINT, STRING, and/or I2D
    InteractantInteraction Details
    GeneCardExternal ID(s)
    CREB3O438893I2D: score=1 
    S100BP042713I2D: score=1 
    VTNENSP000002262184STRING: ENSP00000226218
    About this table

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for ADTRP

    Search CenterWatch for drugs/clinical trials and news about ADTRP

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for ADTRP gene (2 alternative transcripts): 
    NM_001143948.1  NM_032744.3  

    Unigene Cluster for ADTRP:

    Androgen-dependent TFPI-regulating protein
    Hs.126409  [show with all ESTs]
    Unigene Representative Sequence: AK123258
    11 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000505099 ENST00000414691(uc011dip.2 uc003nab.3) ENST00000514824(uc003naa.3)
    ENST00000513651 ENST00000512139 ENST00000229583 ENST00000503285 ENST00000379415
    ENST00000506810 ENST00000485323 ENST00000379413
    miRNA
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    Inhib. RNA
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    Additional mRNA sequence: 

    AJ420520.1 AK123258.1 AK300919.1 AK310611.1 AK313114.1 BC007011.1 

    7 DOTS entries:

    DT.107414  DT.121365752  DT.40128440  DT.91754499  DT.99931085  DT.100020897  DT.40119004 

    24/50 AceView cDNA sequences (see all 50):

    BG740489 BM710493 AA772671 CA448374 BX103449 BF475842 BX360750 AI147084 
    BM922289 BG696998 BI459991 AI825060 BX360749 AA426092 AI656760 AW130198 
    CA306072 BC007011 BM716339 BG741725 NM_032744 AI652898 AI336841 CA394382 

    GeneLoc Exon Structure

    5/6 Alternative Splicing Database (ASD) splice patterns (SP) for ADTRP (see all 6)    About this scheme

    ExUns: 1 ^ 2a · 2b ^ 3 ^ 4a · 4b ^ 5 ^ 6a · 6b ^ 7 ^ 8 ^ 9a · 9b ^ 10
    SP1:                                                        -                 -         
    SP2:                                      -                 -           -     -         
    SP3:        -                                                                           
    SP4:                                                        -                           
    SP5:                                                                    -     -         


    ECgene alternative splicing isoforms for ADTRP

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    ADTRP expression in normal human tissues (normalized intensities)      ADTRP embryonic expression: see
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: --
    ADTRP Expression
    About this image


    ADTRP expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database 
     5/4 selected tissues (see all 4) fully expand
     
     Adipose (Muscoskeletal System)    fully expand to see all 3 entries
             Mesenchymal Stem Cells Subcutaneous White Adipose
             Thoracic Perivascular Adipose
     
     Blood (Hematopoietic System)    fully expand to see all 2 entries
             Granulocytes Peripheral Blood
             CD19+ B Cells   
     
     Endothelium (Cardiovascular System)
             Human umbilical vein endothelial cells (HUVEC)
     
     Uncategorized (Uncategorized)
             PureStem Progenitor E44

    See ADTRP Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for ADTRP

    SOURCE GeneReport for Unigene cluster: Hs.126409

    UniProtKB/Swiss-Prot: ADTRP_HUMAN, Q96IZ2
    Tissue specificity: Expressed in cultured endothelial cells and in placenta

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    In Situ
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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of animals.

    Orthologs for ADTRP gene from 6/13 species (see all 13)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Adtrp1 , 5 RIKEN cDNA 9530008L14 gene5
    androgen dependent TFPI regulating protein1
    74.24(n)1
    65.5(a)1
      13 (20.61 cM)5
    1092541  NM_001145875.11  NP_001139347.11 
     417631485 
    chicken
    (Gallus gallus)
    Aves C2H6orf1051 chromosome 2 open reading frame, human C6orf105 61.69(n)
    50.23(a)
      771464  XM_001234746.1  XP_001234747.1 
    lizard
    (Anolis carolinensis)
    Reptilia ADTRP6
    --
    --
    45(a)
    31(a)
    1 ↔ 1
    possible ortholog
    GL343209.1(3167227-3208347)
    GL343770.1(108320-123838)
    zebrafish
    (Danio rerio)
    Actinopterygii zgc:1121751 zgc:112175 52.55(n)
    42.34(a)
      550414  NM_001017719.1  NP_001017719.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta CG61496
    CG36256
    (see all 3)
    --
    29(a)
    29(a)
    (see all 3)
    many ↔ many
    many ↔ many
    (see all 3)
    3L(11427795-11428576)
    2L(283384-291751)
    worm
    (Caenorhabditis elegans)
    Secernentea C37E2.26
    C37E2.36
    Protein C37E2.3
    19(a)
    17(a)
    many ↔ many
    many ↔ many
    X(14176050-14178471)
    X(14178988-14181705)


    ENSEMBL Gene Tree for ADTRP (if available)
    TreeFam Gene Tree for ADTRP (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for ADTRP gene
    AIG12  
    1 SIMAP similar gene for ADTRP using alignment to 6 protein entries:     ADTRP_HUMAN (see all proteins):
    AIG1

    ADTRP for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/1462 SNPs in ADTRP are shown (see all 1462)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 6 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs567501421,2
    C--11646269(+) AAAAA-/A/A   
       A
    /AAA
    TGGCC
    6 -- ut311NA 2
    rs1116812701,2
    C,F--11713525(+) GTCCTC/TTTCTG 2 -- int12Minor allele frequency- T:0.03CSA WA 120
    rs1485793961,2
    --11713540(+) CCTTCA/TAGACC 2 -- int10--------
    rs174013891,2
    C,F--11713593(+) GTTGGG/TAAGTC 2 -- int13Minor allele frequency- T:0.01NA 140
    rs1464135071,2
    --11713645(+) AGCCTA/GGTGAC 2 -- int10--------
    rs1915823431,2
    --11713916(+) ACTATA/GCCATT 2 -- ut310--------
    rs1838835731,2
    --11713917(+) CTATAA/CCATTT 2 -- ut310--------
    rs3681922741,2
    C--11713931(+) TGATGA/TTTAAT 2 -- ut310--------
    rs1879455021,2
    --11714014(+) CAGAAA/GAGAAA 2 -- ut310--------
    rs1398785881,2
    C--11714129(+) TTTTAA/GATCAC 2 -- ut310--------

    HapMap Linkage Disequilibrium report for ADTRP (11712287 - 11807279 bp)

    Structural Variations
          Database of Genomic Variants (DGV) variations for ADTRP: --
    SABiosciences Cancer Mutation PCR Assays
    SeqTarget long-range PCR primers for resequencing ADTRP
    DNA2.0 Custom Variant and Variant Library Synthesis for ADTRP

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    OMIM gene information: 614348    OMIM disorders: --

    2 diseases for ADTRP:    About MalaCards
    endotheliitis    


    ADTRP for disorders           About GeneDecksing


    Export disorders for ADTRP gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for ADTRP gene, integrated from 9 sources (see all 11):
    (articles sorted by number of sources associating them with ADTRP)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Novel protein ADTRP regulates TFPI expression and function in human endothelial cells in normal conditions and in response to androgen. (PubMed id 21868574)1, 2, 3 Lupu C.... Lupu F. (2011)
    2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    3. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (2004)
    4. The DNA sequence and analysis of human chromosome 6. (PubMed id 14574404)1, 2 Mungall A.J.... Beck S. (2003)
    5. Toward an understanding of the protein interaction net work of the human liver. (PubMed id 21988832)1 Wang J....Yang X. (2011)
    6. Genome-wide association identifies a susceptibility l ocus for coronary artery disease in the Chinese Han population. (PubMed id 21378986)1 Wang F....Wang Q.K. (2011)
    7. Evidence for gene-environment interaction in a genome wide study of nonsyndromic cleft palate. (PubMed id 21618603)1 Beaty T.H....Scott A.F. (2011)
    8. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PubMed id 20379614)1 Rose J.E....Uhl G.R. (2010)
    9. High throughput SNP and expression analyses of candidate genes for non-syndromic oral clefts. (PubMed id 16415175)1 Park J.W....Beaty T.H. (2006)
    10. Sequence comparison of human and mouse genes reveals a homologous block structure in the promoter regions. (PubMed id 15342556)1 Suzuki Y.... Sugano S. (2004)

    (in PubMed, OMIM, and NCBI Bookshelf)
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    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 84830 HGNC: 21214 AceView: C6orf105 Ensembl:ENSG00000111863 euGenes: HUgn84830
    ECgene: ADTRP H-InvDB: ADTRP

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for ADTRP Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for ADTRP gene:
    Search GeneIP for patents involving ADTRP

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0 and Sirion Biotech, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Sirion Biotech, Cell lines from GenScript, and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences, In Situ Hybridization Assays from
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    GeneCards Homepage - Last full update: 23 Oct 2013 - Incrementals: 3 Nov 2013 , 7 Nov 2013 , 23 Jan 2014

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