Free for academic non-profit institutions. Other users need a Commercial license

Aliases for ADTRP Gene

Aliases for ADTRP Gene

  • Androgen-Dependent TFPI-Regulating Protein 2 3
  • C6orf105 3 4
  • Androgen-Dependent TPF1-Regulating Protein 3
  • Chromosome 6 Open Reading Frame 105 2
  • Androgen-Induced 1-Like 2
  • DJ413H6.1 3
  • C6orf105, 6
  • AIG1L 3

External Ids for ADTRP Gene

Previous HGNC Symbols for ADTRP Gene

  • C6orf105

Summaries for ADTRP Gene

GeneCards Summary for ADTRP Gene

ADTRP (Androgen-Dependent TFPI-Regulating Protein) is a Protein Coding gene. An important paralog of this gene is AIG1.

UniProtKB/Swiss-Prot for ADTRP Gene

  • Regulates the expression and the cell-associated anticoagulant activity of the inhibitor TFPI in endothelial cells (in vitro).

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ADTRP Gene

Genomics for ADTRP Gene

Genomic Location for ADTRP Gene

Start:
11,712,054 bp from pter
End:
11,807,046 bp from pter
Size:
94,993 bases
Orientation:
Minus strand

Genomic View for ADTRP Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for ADTRP Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ADTRP Gene

No data available for Regulatory Elements for ADTRP Gene

Proteins for ADTRP Gene

  • Protein details for ADTRP Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q96IZ2-ADTRP_HUMAN
    Recommended name:
    Androgen-dependent TFPI-regulating protein
    Protein Accession:
    Q96IZ2
    Secondary Accessions:
    • B2R7T9
    • B4DV39
    • Q5THW1

    Protein attributes for ADTRP Gene

    Size:
    230 amino acids
    Molecular mass:
    26842 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for ADTRP Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for ADTRP Gene

Proteomics data for ADTRP Gene at MOPED

Post-translational modifications for ADTRP Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for ADTRP Gene

Domains for ADTRP Gene

Protein Domains for ADTRP Gene

InterPro:
ProtoNet:

Graphical View of Domain Structure for InterPro Entry

Q96IZ2

UniProtKB/Swiss-Prot:

ADTRP_HUMAN :
  • Q96IZ2
Family:
  • Belongs to the AIG1 family.
genes like me logo Genes that share domains with ADTRP: view

No data available for Gene Families and Suggested Antigen Peptide Sequences for ADTRP Gene

Function for ADTRP Gene

Molecular function for ADTRP Gene

UniProtKB/Swiss-Prot Function: Regulates the expression and the cell-associated anticoagulant activity of the inhibitor TFPI in endothelial cells (in vitro).
UniProtKB/Swiss-Prot Induction: By androgens.

Phenotypes for ADTRP Gene

GenomeRNAi human phenotypes for ADTRP:
genes like me logo Genes that share phenotypes with ADTRP: view

Animal Model Products

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for ADTRP

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Animal Models , miRNA , Transcription Factor Targeting and HOMER Transcription for ADTRP Gene

Localization for ADTRP Gene

Subcellular locations from UniProtKB/Swiss-Prot for ADTRP Gene

Cell membrane; Multi-pass membrane protein. Note=Colocalized with TFPI and CAV1 in lipid rafts.

Gene Ontology (GO) - Cellular Components for ADTRP Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005886 plasma membrane IEA --
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with ADTRP: view

No data available for Subcellular locations from COMPARTMENTS for ADTRP Gene

Pathways for ADTRP Gene

SuperPathways for ADTRP Gene

No Data Available

Interacting Proteins for ADTRP Gene

Gene Ontology (GO) - Biological Process for ADTRP Gene

None

No data available for Pathways by source for ADTRP Gene

Transcripts for ADTRP Gene

Unigene Clusters for ADTRP Gene

Androgen-dependent TFPI-regulating protein:
Representative Sequences:

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for ADTRP

Primer Products

  • QuantiTect SYBR Green Assays in human,mouse,rat
  • Pre-validated RT² qPCR Primer Assay in human,mouse,rat
  • QuantiFast Probe-based Assays in human,mouse,rat

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for ADTRP Gene

ExUns: 1 ^ 2a · 2b ^ 3 ^ 4a · 4b ^ 5 ^ 6a · 6b ^ 7 ^ 8 ^ 9a · 9b ^ 10
SP1: - -
SP2: - - - -
SP3: -
SP4: -
SP5: - -
SP6:

Relevant External Links for ADTRP Gene

GeneLoc Exon Structure for
ADTRP
ECgene alternative splicing isoforms for
ADTRP

Expression for ADTRP Gene

mRNA expression in normal human tissues for ADTRP Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for ADTRP Gene

This gene is overexpressed in Colon - Transverse (15.0), Small Intestine - Terminal Ileum (7.4), Stomach (5.3), and Skin - Not Sun Exposed (Suprapubic) (4.5).

SOURCE GeneReport for Unigene cluster for ADTRP Gene Hs.126409

mRNA Expression by UniProt/SwissProt for ADTRP Gene

Q96IZ2-ADTRP_HUMAN
Tissue specificity: Expressed in cultured endothelial cells and in placenta.
genes like me logo Genes that share expressions with ADTRP: view

In Situ Assay Products

No data available for Protein expression for ADTRP Gene

Orthologs for ADTRP Gene

This gene was present in the common ancestor of animals.

Orthologs for ADTRP Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia ADTRP 35
  • 98.84 (n)
  • 98.7 (a)
ADTRP 36
  • 99 (a)
OneToOne
cow
(Bos Taurus)
Mammalia ADTRP 35
  • 80.87 (n)
  • 75.22 (a)
C23H6ORF105 36
  • 72 (a)
OneToOne
dog
(Canis familiaris)
Mammalia ADTRP 35
  • 82.46 (n)
  • 75.22 (a)
ADTRP 36
  • 72 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Adtrp 35
  • 74.2 (n)
  • 65.22 (a)
Adtrp 16
Adtrp 36
  • 56 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia ADTRP 36
  • 46 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia ADTRP 36
  • 53 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Adtrp 35
  • 75.07 (n)
  • 68.26 (a)
chicken
(Gallus gallus)
Aves ADTRP 36
  • 48 (a)
OneToOne
C2H6ORF105 35
  • 61.01 (n)
  • 49.57 (a)
lizard
(Anolis carolinensis)
Reptilia ADTRP 36
  • 44 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia adtrp 35
  • 55.02 (n)
  • 43.67 (a)
zebrafish
(Danio rerio)
Actinopterygii ADTRP 36
  • 35 (a)
OneToOne
LOC100537455 35
  • 51.5 (n)
  • 40.76 (a)
fruit fly
(Drosophila melanogaster)
Insecta CG11601 36
  • 23 (a)
ManyToMany
CG3625 36
  • 30 (a)
ManyToMany
CG6149 36
  • 29 (a)
ManyToMany
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 30 (a)
OneToMany
Species with no ortholog for ADTRP:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for ADTRP Gene

ENSEMBL:
Gene Tree for ADTRP (if available)
TreeFam:
Gene Tree for ADTRP (if available)

Paralogs for ADTRP Gene

Paralogs for ADTRP Gene

Selected SIMAP similar genes for ADTRP Gene using alignment to 6 proteins:

genes like me logo Genes that share paralogs with ADTRP: view

Variants for ADTRP Gene

Sequence variations from dbSNP and Humsavar for ADTRP Gene

SNP ID Clin Chr 06 pos Sequence Context AA Info Type MAF
rs105924 -- 11,729,826(-) GTAAT(A/C)GTCTT intron-variant
rs169790 -- 11,714,058(+) ACTAA(A/G)TAACC utr-variant-3-prime
rs169791 -- 11,746,784(-) GCAAG(C/T)GCCTG intron-variant
rs172403 -- 11,734,105(-) CTGAT(C/T)ATACA intron-variant
rs172404 -- 11,734,031(-) AATCT(G/T)GTAGT intron-variant

Relevant External Links for ADTRP Gene

HapMap Linkage Disequilibrium report
ADTRP
Human Gene Mutation Database (HGMD)
ADTRP

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Structural Variations from Database of Genomic Variants (DGV) for ADTRP Gene

Disorders for ADTRP Gene

No disorders were found for ADTRP Gene.

No data available for UniProtKB/Swiss-Prot for ADTRP Gene

Publications for ADTRP Gene

  1. Novel protein ADTRP regulates TFPI expression and function in human endothelial cells in normal conditions and in response to androgen. (PMID: 21868574) Lupu C. … Lupu F. (Blood 2011) 2 3 4
  2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4
  3. The DNA sequence and analysis of human chromosome 6. (PMID: 14574404) Mungall A.J. … Beck S. (Nature 2003) 3 4
  4. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4
  5. Sequence comparison of human and mouse genes reveals a homologous block structure in the promoter regions. (PMID: 15342556) Suzuki Y. … Sugano S. (Genome Res. 2004) 3

Products for ADTRP Gene

Sources for ADTRP Gene

Back to Top

Content