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Aliases for ADTRP Gene

Aliases for ADTRP Gene

  • Androgen Dependent TFPI Regulating Protein 2 3
  • Androgen-Dependent TFPI-Regulating Protein 2 5
  • C6orf105 3 4
  • Androgen-Dependent TPF1-Regulating Protein 3
  • Chromosome 6 Open Reading Frame 105 2
  • Androgen-Induced 1-Like 2
  • DJ413H6.1 3
  • AIG1L 3

External Ids for ADTRP Gene

Previous HGNC Symbols for ADTRP Gene

  • C6orf105

Summaries for ADTRP Gene

GeneCards Summary for ADTRP Gene

ADTRP (Androgen Dependent TFPI Regulating Protein) is a Protein Coding gene. An important paralog of this gene is AIG1.

UniProtKB/Swiss-Prot for ADTRP Gene

  • Regulates the expression and the cell-associated anticoagulant activity of the inhibitor TFPI in endothelial cells (in vitro).

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ADTRP Gene

Genomics for ADTRP Gene

Regulatory Elements for ADTRP Gene

Enhancers for ADTRP Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around ADTRP on UCSC Golden Path with GeneCards custom track

Promoters for ADTRP Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around ADTRP on UCSC Golden Path with GeneCards custom track

Genomic Location for ADTRP Gene

Chromosome:
6
Start:
11,712,054 bp from pter
End:
11,807,046 bp from pter
Size:
94,993 bases
Orientation:
Minus strand

Genomic View for ADTRP Gene

Genes around ADTRP on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ADTRP Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ADTRP Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ADTRP Gene

Proteins for ADTRP Gene

  • Protein details for ADTRP Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q96IZ2-ADTRP_HUMAN
    Recommended name:
    Androgen-dependent TFPI-regulating protein
    Protein Accession:
    Q96IZ2
    Secondary Accessions:
    • B2R7T9
    • B4DV39
    • Q5THW1

    Protein attributes for ADTRP Gene

    Size:
    230 amino acids
    Molecular mass:
    26842 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for ADTRP Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for ADTRP Gene

Proteomics data for ADTRP Gene at MOPED

Post-translational modifications for ADTRP Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for ADTRP Gene

Domains & Families for ADTRP Gene

Protein Domains for ADTRP Gene

InterPro:
ProtoNet:

Graphical View of Domain Structure for InterPro Entry

Q96IZ2

UniProtKB/Swiss-Prot:

ADTRP_HUMAN :
  • Belongs to the AIG1 family.
Family:
  • Belongs to the AIG1 family.
genes like me logo Genes that share domains with ADTRP: view

No data available for Gene Families and Suggested Antigen Peptide Sequences for ADTRP Gene

Function for ADTRP Gene

Molecular function for ADTRP Gene

UniProtKB/Swiss-Prot Function:
Regulates the expression and the cell-associated anticoagulant activity of the inhibitor TFPI in endothelial cells (in vitro).
UniProtKB/Swiss-Prot Induction:
By androgens.
genes like me logo Genes that share phenotypes with ADTRP: view

Animal Model Products

miRNA for ADTRP Gene

miRTarBase miRNAs that target ADTRP

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for ADTRP Gene

Localization for ADTRP Gene

Subcellular locations from UniProtKB/Swiss-Prot for ADTRP Gene

Cell membrane; Multi-pass membrane protein. Note=Colocalized with TFPI and CAV1 in lipid rafts.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for ADTRP Gene COMPARTMENTS Subcellular localization image for ADTRP gene
Compartment Confidence
plasma membrane 4
peroxisome 1

Gene Ontology (GO) - Cellular Components for ADTRP Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005886 plasma membrane IEA --
genes like me logo Genes that share ontologies with ADTRP: view

Pathways & Interactions for ADTRP Gene

SuperPathways for ADTRP Gene

No Data Available

Interacting Proteins for ADTRP Gene

Gene Ontology (GO) - Biological Process for ADTRP Gene

None

No data available for Pathways by source and SIGNOR curated interactions for ADTRP Gene

Drugs & Compounds for ADTRP Gene

No Compound Related Data Available

Transcripts for ADTRP Gene

Unigene Clusters for ADTRP Gene

Androgen-dependent TFPI-regulating protein:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for ADTRP Gene

ExUns: 1 ^ 2a · 2b ^ 3 ^ 4a · 4b ^ 5 ^ 6a · 6b ^ 7 ^ 8 ^ 9a · 9b ^ 10
SP1: - -
SP2: - - - -
SP3: -
SP4: -
SP5: - -
SP6:

Relevant External Links for ADTRP Gene

GeneLoc Exon Structure for
ADTRP
ECgene alternative splicing isoforms for
ADTRP

Expression for ADTRP Gene

mRNA expression in normal human tissues for ADTRP Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for ADTRP Gene

This gene is overexpressed in Colon - Transverse (x15.0), Small Intestine - Terminal Ileum (x7.4), Stomach (x5.3), and Skin - Not Sun Exposed (Suprapubic) (x4.5).

SOURCE GeneReport for Unigene cluster for ADTRP Gene Hs.126409

mRNA Expression by UniProt/SwissProt for ADTRP Gene

Q96IZ2-ADTRP_HUMAN
Tissue specificity: Expressed in cultured endothelial cells and in placenta.
genes like me logo Genes that share expression patterns with ADTRP: view

Primer Products

No data available for Protein differential expression in normal tissues , Protein expression and Protein tissue co-expression partners for ADTRP Gene

Orthologs for ADTRP Gene

This gene was present in the common ancestor of animals.

Orthologs for ADTRP Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia ADTRP 35
  • 80.87 (n)
  • 75.22 (a)
C23H6ORF105 36
  • 72 (a)
OneToOne
dog
(Canis familiaris)
Mammalia ADTRP 35
  • 82.46 (n)
  • 75.22 (a)
ADTRP 36
  • 72 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Adtrp 35
  • 74.2 (n)
  • 65.22 (a)
Adtrp 16
Adtrp 36
  • 56 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia ADTRP 35
  • 98.84 (n)
  • 98.7 (a)
ADTRP 36
  • 99 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Adtrp 35
  • 75.07 (n)
  • 68.26 (a)
oppossum
(Monodelphis domestica)
Mammalia ADTRP 36
  • 46 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia ADTRP 36
  • 53 (a)
OneToOne
chicken
(Gallus gallus)
Aves C2H6ORF105 35
  • 61.01 (n)
  • 49.57 (a)
ADTRP 36
  • 48 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia ADTRP 36
  • 44 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia adtrp 35
  • 55.02 (n)
  • 43.67 (a)
zebrafish
(Danio rerio)
Actinopterygii LOC100537455 35
  • 51.5 (n)
  • 40.76 (a)
ADTRP 36
  • 35 (a)
OneToOne
fruit fly
(Drosophila melanogaster)
Insecta CG11601 36
  • 23 (a)
ManyToMany
CG3625 36
  • 30 (a)
ManyToMany
CG6149 36
  • 29 (a)
ManyToMany
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 30 (a)
OneToMany
Species with no ortholog for ADTRP:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for ADTRP Gene

ENSEMBL:
Gene Tree for ADTRP (if available)
TreeFam:
Gene Tree for ADTRP (if available)

Paralogs for ADTRP Gene

Paralogs for ADTRP Gene

(1) SIMAP similar genes for ADTRP Gene using alignment to 6 proteins:

genes like me logo Genes that share paralogs with ADTRP: view

Variants for ADTRP Gene

Sequence variations from dbSNP and Humsavar for ADTRP Gene

SNP ID Clin Chr 06 pos Sequence Context AA Info Type
VAR_024365 -
rs5874340 -- 11,731,766(+) TTTTT(-/A)ATGAG intron-variant, utr-variant-3-prime
rs6457810 -- 11,740,001(+) CTGCT(G/T)CTTTC intron-variant
rs6457825 -- 11,767,387(+) TTTAC(A/G)TGGGC intron-variant
rs6903956 -- 11,774,350(+) CATAG(A/G)TTATT intron-variant

Variation tolerance for ADTRP Gene

Residual Variation Intolerance Score: 41.2% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 7.31; 81.43% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for ADTRP Gene

Human Gene Mutation Database (HGMD)
ADTRP

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Structural Variations from Database of Genomic Variants (DGV) for ADTRP Gene

Disorders for ADTRP Gene

Relevant External Links for ADTRP

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
ADTRP

No disorders were found for ADTRP Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for ADTRP Gene

Publications for ADTRP Gene

  1. Novel protein ADTRP regulates TFPI expression and function in human endothelial cells in normal conditions and in response to androgen. (PMID: 21868574) Lupu C. … Lupu F. (Blood 2011) 2 3 4 67
  2. The coronary artery disease-associated gene C6ORF105 is expressed in human macrophages under the transcriptional control of PPARI^. (PMID: 25595457) Chinetti-Gbaguidi G. … Staels B. (FEBS Lett. 2015) 3
  3. A coronary artery disease-associated SNP rs6903956 contributed to asymptomatic hyperuricemia susceptibility in Han Chinese. (PMID: 25928384) Meng J. … Zhang M. (Lipids Health Dis 2015) 3
  4. Associations between the CDKN2A/B, ADTRP and PDGFD polymorphisms and the development of coronary atherosclerosis in Japanese patients. (PMID: 24573017) Dechamethakun S. … Muramatsu M. (J. Atheroscler. Thromb. 2014) 3
  5. Association of single nucleotide polymorphism rs6903956 on chromosome 6p24.1 with coronary artery disease and lipid levels in different ethnic groups of the Singaporean population. (PMID: 23337689) Tayebi N. … Heng C.K. (Clin. Biochem. 2013) 3

Products for ADTRP Gene

Sources for ADTRP Gene

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