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Aliases for ADTRP Gene

Aliases for ADTRP Gene

  • Androgen Dependent TFPI Regulating Protein 2 3 5
  • Androgen-Dependent TFPI-Regulating Protein 2 3
  • C6orf105 3 4
  • Androgen-Dependent TPF1-Regulating Protein 3
  • Chromosome 6 Open Reading Frame 105 2
  • Androgen-Induced 1-Like 2
  • DJ413H6.1 3
  • AIG1L 3

External Ids for ADTRP Gene

Previous HGNC Symbols for ADTRP Gene

  • C6orf105

Summaries for ADTRP Gene

GeneCards Summary for ADTRP Gene

ADTRP (Androgen Dependent TFPI Regulating Protein) is a Protein Coding gene. An important paralog of this gene is AIG1.

UniProtKB/Swiss-Prot for ADTRP Gene

  • Regulates the expression and the cell-associated anticoagulant activity of the inhibitor TFPI in endothelial cells (in vitro).

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ADTRP Gene

Genomics for ADTRP Gene

Regulatory Elements for ADTRP Gene

Enhancers for ADTRP Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH06F011754 0.2 ENCODE 28.2 +52.1 52068 1.5 ADTRP GC06M011750 GC06P011785
GH06F011777 1.3 Ensembl ENCODE 19.3 +27.9 27934 2.3 HDAC1 ATF1 NFRKB ZBTB40 CHAMP1 ZNF766 GATA2 ETV6 CREM SMAD5 ADTRP GC06P011785 GC06M011750
GH06F011765 1.4 FANTOM5 Ensembl ENCODE 18 +37.6 37640 8.8 SIN3A ZNF766 FOS DEK REST MAFF SMARCA4 STAT3 KDM1A CTCF ADTRP HIVEP1 ENSG00000271897 TMEM170B NEDD9 GC06M011750 GC06P011785
GH06F011749 0.2 ENCODE 16.6 +56.1 56128 2.3 GFI1B BHLHE40 FEZF1 ZEB2 ZNF843 RAD21 YY1 ZNF335 ATF3 ZNF580 ADTRP EDN1 GC06M011750 GC06P011709
GH06F011759 1.1 Ensembl ENCODE 16.2 +45.1 45133 4.6 ESRRA NR2F1 BHLHE40 MAFG ZNF316 GATA3 MAFF TCF7 HNF4G MAFK ADTRP GC06M011750 GC06P011785
- Elite enhancer/Elite enhancer-gene association Download Table
Download GeneHancer data dump

Enhancers around ADTRP on UCSC Golden Path with GeneCards custom track

Genomic Location for ADTRP Gene

Chromosome:
6
Start:
11,712,054 bp from pter
End:
11,807,046 bp from pter
Size:
94,993 bases
Orientation:
Minus strand

Genomic View for ADTRP Gene

Genes around ADTRP on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ADTRP Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ADTRP Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ADTRP Gene

Proteins for ADTRP Gene

  • Protein details for ADTRP Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q96IZ2-ADTRP_HUMAN
    Recommended name:
    Androgen-dependent TFPI-regulating protein
    Protein Accession:
    Q96IZ2
    Secondary Accessions:
    • B2R7T9
    • B4DV39
    • Q5THW1

    Protein attributes for ADTRP Gene

    Size:
    230 amino acids
    Molecular mass:
    26842 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for ADTRP Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for ADTRP Gene

Post-translational modifications for ADTRP Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for ADTRP Gene

Domains & Families for ADTRP Gene

Protein Domains for ADTRP Gene

InterPro:
ProtoNet:

Graphical View of Domain Structure for InterPro Entry

Q96IZ2

UniProtKB/Swiss-Prot:

ADTRP_HUMAN :
  • Belongs to the AIG1 family.
Family:
  • Belongs to the AIG1 family.
genes like me logo Genes that share domains with ADTRP: view

No data available for Gene Families and Suggested Antigen Peptide Sequences for ADTRP Gene

Function for ADTRP Gene

Molecular function for ADTRP Gene

UniProtKB/Swiss-Prot Function:
Regulates the expression and the cell-associated anticoagulant activity of the inhibitor TFPI in endothelial cells (in vitro).
UniProtKB/Swiss-Prot Induction:
By androgens.
genes like me logo Genes that share phenotypes with ADTRP: view

Animal Model Products

miRNA for ADTRP Gene

miRTarBase miRNAs that target ADTRP

Inhibitory RNA Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for ADTRP Gene

Localization for ADTRP Gene

Subcellular locations from UniProtKB/Swiss-Prot for ADTRP Gene

Cell membrane; Multi-pass membrane protein. Note=Colocalized with TFPI and CAV1 in lipid rafts.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for ADTRP Gene COMPARTMENTS Subcellular localization image for ADTRP gene
Compartment Confidence
plasma membrane 4
peroxisome 1

Gene Ontology (GO) - Cellular Components for ADTRP Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005886 plasma membrane IEA --
GO:0012505 endomembrane system IBA --
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with ADTRP: view

Pathways & Interactions for ADTRP Gene

SuperPathways for ADTRP Gene

No Data Available

Interacting Proteins for ADTRP Gene

Gene Ontology (GO) - Biological Process for ADTRP Gene

None

No data available for Pathways by source and SIGNOR curated interactions for ADTRP Gene

Transcripts for ADTRP Gene

Unigene Clusters for ADTRP Gene

Androgen-dependent TFPI-regulating protein:
Representative Sequences:

Inhibitory RNA Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for ADTRP Gene

ExUns: 1 ^ 2a · 2b ^ 3 ^ 4a · 4b ^ 5 ^ 6a · 6b ^ 7 ^ 8 ^ 9a · 9b ^ 10
SP1: - -
SP2: - - - -
SP3: -
SP4: -
SP5: - -
SP6:

Relevant External Links for ADTRP Gene

GeneLoc Exon Structure for
ADTRP
ECgene alternative splicing isoforms for
ADTRP

Expression for ADTRP Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for ADTRP Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for ADTRP Gene

This gene is overexpressed in Colon - Transverse (x15.0), Small Intestine - Terminal Ileum (x7.4), Stomach (x5.3), and Skin - Not Sun Exposed (Suprapubic) (x4.5).

NURSA nuclear receptor signaling pathways regulating expression of ADTRP Gene:

ADTRP

SOURCE GeneReport for Unigene cluster for ADTRP Gene:

Hs.126409

mRNA Expression by UniProt/SwissProt for ADTRP Gene:

Q96IZ2-ADTRP_HUMAN
Tissue specificity: Expressed in cultured endothelial cells and in placenta.
genes like me logo Genes that share expression patterns with ADTRP: view

Primer Products

No data available for Protein differential expression in normal tissues , Protein expression and Protein tissue co-expression partners for ADTRP Gene

Orthologs for ADTRP Gene

This gene was present in the common ancestor of animals.

Orthologs for ADTRP Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia ADTRP 34 35
  • 98.84 (n)
dog
(Canis familiaris)
Mammalia ADTRP 34 35
  • 82.46 (n)
cow
(Bos Taurus)
Mammalia ADTRP 34
  • 80.87 (n)
C23H6ORF105 35
  • 72 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Adtrp 34
  • 75.07 (n)
mouse
(Mus musculus)
Mammalia Adtrp 34 16 35
  • 74.2 (n)
platypus
(Ornithorhynchus anatinus)
Mammalia ADTRP 35
  • 53 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia ADTRP 35
  • 46 (a)
OneToOne
chicken
(Gallus gallus)
Aves C2H6ORF105 34
  • 61.01 (n)
ADTRP 35
  • 48 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia ADTRP 35
  • 44 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia adtrp 34
  • 55.02 (n)
zebrafish
(Danio rerio)
Actinopterygii LOC100537455 34
  • 51.5 (n)
ADTRP 35
  • 35 (a)
OneToOne
fruit fly
(Drosophila melanogaster)
Insecta CG3625 35
  • 30 (a)
ManyToMany
CG6149 35
  • 29 (a)
ManyToMany
CG11601 35
  • 23 (a)
ManyToMany
sea squirt
(Ciona savignyi)
Ascidiacea -- 35
  • 30 (a)
OneToMany
Species where no ortholog for ADTRP was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for ADTRP Gene

ENSEMBL:
Gene Tree for ADTRP (if available)
TreeFam:
Gene Tree for ADTRP (if available)

Paralogs for ADTRP Gene

Paralogs for ADTRP Gene

(1) SIMAP similar genes for ADTRP Gene using alignment to 6 proteins:

genes like me logo Genes that share paralogs with ADTRP: view

Variants for ADTRP Gene

Sequence variations from dbSNP and Humsavar for ADTRP Gene

SNP ID Clin Chr 06 pos Sequence Context AA Info Type
rs1000976 -- 11,728,561(+) agaaa(A/G)gattt intron-variant, nc-transcript-variant
rs1009955 -- 11,716,016(-) AGAAG(A/C)CCTAA intron-variant, upstream-variant-2KB
rs10456430 -- 11,762,775(+) CTGAG(A/G)AGTTC intron-variant
rs105924 -- 11,729,826(-) GTAAT(A/C)GTCTT intron-variant, downstream-variant-500B
rs10947543 -- 11,750,897(+) CCCAG(C/G)CCGGA intron-variant

Structural Variations from Database of Genomic Variants (DGV) for ADTRP Gene

Variant ID Type Subtype PubMed ID
esv2759407 CNV loss 17122850
nsv522039 CNV gain 19592680
nsv600990 CNV loss 21841781

Variation tolerance for ADTRP Gene

Residual Variation Intolerance Score: 41.2% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 7.31; 81.43% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for ADTRP Gene

Human Gene Mutation Database (HGMD)
ADTRP
SNPedia medical, phenotypic, and genealogical associations of SNPs for
ADTRP

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ADTRP Gene

Disorders for ADTRP Gene

Relevant External Links for ADTRP

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
ADTRP

No disorders were found for ADTRP Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for ADTRP Gene

Publications for ADTRP Gene

  1. Novel protein ADTRP regulates TFPI expression and function in human endothelial cells in normal conditions and in response to androgen. (PMID: 21868574) Lupu C. … Lupu F. (Blood 2011) 2 3 4 64
  2. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4 64
  3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4 64
  4. The DNA sequence and analysis of human chromosome 6. (PMID: 14574404) Mungall A.J. … Beck S. (Nature 2003) 3 4 64
  5. AIG1 and ADTRP are atypical integral membrane hydrolases that degrade bioactive FAHFAs. (PMID: 27018888) Parsons W.H. … Cravatt B.F. (Nat. Chem. Biol. 2016) 3 64

Products for ADTRP Gene

Sources for ADTRP Gene

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