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Aliases for ADSS Gene

Aliases for ADSS Gene

  • Adenylosuccinate Synthase 2 3
  • Adenylosuccinate Synthetase, Acidic Isozyme 3 4
  • Adenylosuccinate Synthetase, Liver Isozyme 3 4
  • L-Type Adenylosuccinate Synthetase 3 4
  • IMP--Aspartate Ligase 2 3 4
  • EC 6.3.4.4 4 64
  • AMPSase 2 3 4
  • Adenylosuccinate Synthetase (Ade(-)H-Complementing) 3
  • Adenylosuccinate Synthetase Isozyme 2 3
  • ADSS 2 3
  • AdSS 2 4
  • ADSS2 4
  • ADEH 3

External Ids for ADSS Gene

Summaries for ADSS Gene

Entrez Gene Summary for ADSS Gene

  • This gene encodes the enzyme adenylosuccinate synthetase which catalyzes the first committed step in the conversion of inosine monophosphate to adenosine monophosphate. A pseudogene of this gene is found on chromosome 17.[provided by RefSeq, Nov 2010]

GeneCards Summary for ADSS Gene

ADSS (Adenylosuccinate Synthase) is a Protein Coding gene. Diseases associated with ADSS include relapsing fever. Among its related pathways are Metabolism and Metabolism. GO annotations related to this gene include GTP binding and phosphate ion binding. An important paralog of this gene is ADSSL1.

UniProtKB/Swiss-Prot for ADSS Gene

  • Plays an important role in the de novo pathway and in the salvage pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP

No data available for Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ADSS Gene

Genomics for ADSS Gene

Genomic Location for ADSS Gene

Start:
244,408,492 bp from pter
End:
244,452,134 bp from pter
Size:
43,643 bases
Orientation:
Minus strand

Genomic View for ADSS Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for ADSS Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ADSS Gene

Regulatory Elements for ADSS Gene

Proteins for ADSS Gene

  • Protein details for ADSS Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P30520-PURA2_HUMAN
    Recommended name:
    Adenylosuccinate synthetase isozyme 2
    Protein Accession:
    P30520
    Secondary Accessions:
    • B1AQM5
    • Q96EG7

    Protein attributes for ADSS Gene

    Size:
    456 amino acids
    Molecular mass:
    50097 Da
    Cofactor:
    Name=Mg(2+); Xref=ChEBI:CHEBI:18420; Note=Binds 1 Mg(2+) ion per subunit.;
    Quaternary structure:
    • Homodimer.

    Three dimensional structures from OCA and Proteopedia for ADSS Gene

neXtProt entry for ADSS Gene

Proteomics data for ADSS Gene at MOPED

Post-translational modifications for ADSS Gene

  • Modification sites at PhosphoSitePlus
  • Ubiquitination at Lys173, Lys403, Lys419, and Lys441

Other Protein References for ADSS Gene

ENSEMBL proteins:
Reactome Protein details:
REFSEQ proteins:

Domains for ADSS Gene

UniProtKB/Swiss-Prot:

PURA2_HUMAN
Family:
  • Belongs to the adenylosuccinate synthetase family.:
    • P30520
genes like me logo Genes that share domains with ADSS: view

No data available for Gene Families for ADSS Gene

Function for ADSS Gene

Molecular function for ADSS Gene

GENATLAS Biochemistry: adenylosuccinate synthase,purine nucleotide cycle
UniProtKB/Swiss-Prot CatalyticActivity: GTP + IMP + L-aspartate = GDP + phosphate + N(6)-(1,2-dicarboxyethyl)-AMP.
UniProtKB/Swiss-Prot Function: Plays an important role in the de novo pathway and in the salvage pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP

Enzyme Numbers (IUBMB) for ADSS Gene

Gene Ontology (GO) - Molecular Function for ADSS Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000287 magnesium ion binding IEA --
GO:0004019 adenylosuccinate synthase activity NAS 1592113
GO:0005515 protein binding IPI 23455924
GO:0005525 GTP binding NAS 15786719
GO:0042301 phosphate ion binding NAS 15786719
genes like me logo Genes that share ontologies with ADSS: view

Phenotypes for ADSS Gene

genes like me logo Genes that share phenotypes with ADSS: view

miRNA for ADSS Gene

miRTarBase miRNAs that target ADSS

No data available for Animal Models , Transcription Factor Targeting and HOMER Transcription for ADSS Gene

Localization for ADSS Gene

Subcellular locations from UniProtKB/Swiss-Prot for ADSS Gene

Cytoplasm. Note=Partially associated with particulate fractions.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for ADSS Gene COMPARTMENTS Subcellular localization image for ADSS gene
Compartment Confidence
cytosol 4
plasma membrane 4
mitochondrion 3
nucleus 2
extracellular 1

Gene Ontology (GO) - Cellular Components for ADSS Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm IDA --
GO:0005829 cytosol TAS --
GO:0005886 plasma membrane IDA --
GO:0070062 extracellular exosome IDA 23533145
genes like me logo Genes that share ontologies with ADSS: view

Pathways for ADSS Gene

genes like me logo Genes that share pathways with ADSS: view

Pathways by source for ADSS Gene

UniProtKB/Swiss-Prot P30520-PURA2_HUMAN

  • Pathway: Purine metabolism; AMP biosynthesis via de novo pathway; AMP from IMP: step 1/2.

Gene Ontology (GO) - Biological Process for ADSS Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0002376 immune system process NAS 15786719
GO:0006144 purine nucleobase metabolic process TAS --
GO:0006164 purine nucleotide biosynthetic process --
GO:0006167 AMP biosynthetic process NAS 15786719
GO:0006184 obsolete GTP catabolic process --
genes like me logo Genes that share ontologies with ADSS: view

Compounds for ADSS Gene

(7) HMDB Compounds for ADSS Gene

Compound Synonyms Cas Number PubMed IDs
Adenylsuccinic acid
  • 6-Succino-5'-adenylate
19046-78-7
Guanosine diphosphate
  • 5'-GDP
146-91-8
Guanosine triphosphate
  • 5'-GTP
86-01-1
Inosinic acid
  • 5'-IMP
131-99-7
L-Aspartic acid
  • (+)-Aspartate
56-84-8

(1) Drugbank Compounds for ADSS Gene

Compound Synonyms Cas Number Type Actions PubMed IDs
L-Aspartic Acid
  • (+)-Aspartic acid
56-84-8 target

(10) Novoseek inferred chemical compound relationships for ADSS Gene

Compound -log(P) Hits PubMed IDs
adenylosuccinate 98.6 50
hadacidin 90.6 1
l-alanosine 86.6 3
prpp 77.6 4
purine 72.9 8
genes like me logo Genes that share compounds with ADSS: view

Transcripts for ADSS Gene

Unigene Clusters for ADSS Gene

Adenylosuccinate synthase:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for ADSS Gene

ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8a · 8b ^ 9a · 9b ^ 10 ^ 11 ^ 12 ^ 13a · 13b ^ 14 ^ 15a · 15b ^ 16
SP1: - - - - - -
SP2: - - -
SP3: - -
SP4:
SP5:
SP6:

Relevant External Links for ADSS Gene

GeneLoc Exon Structure for
ADSS
ECgene alternative splicing isoforms for
ADSS

Expression for ADSS Gene

mRNA expression in normal human tissues for ADSS Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for ADSS Gene

SOURCE GeneReport for Unigene cluster for ADSS Gene Hs.498313

genes like me logo Genes that share expressions with ADSS: view

Orthologs for ADSS Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for ADSS Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia ADSS 36
  • 99.85 (n)
  • 99.54 (a)
ADSS 37
  • 99 (a)
OneToOne
cow
(Bos Taurus)
Mammalia ADSS 36
  • 94.52 (n)
  • 98.46 (a)
ADSS 37
  • 98 (a)
OneToOne
dog
(Canis familiaris)
Mammalia ADSS 36
  • 93.93 (n)
  • 98.03 (a)
ADSS 37
  • 98 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Adss 36
  • 91.96 (n)
  • 96.71 (a)
Adss 16
Adss 37
  • 97 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia ADSS 37
  • 91 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia ADSS 37
  • 95 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Adss 36
  • 90.79 (n)
  • 97.37 (a)
chicken
(Gallus gallus)
Aves ADSS 36
  • 81.08 (n)
  • 90.24 (a)
ADSS 37
  • 91 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia ADSS 37
  • 89 (a)
OneToOne
African clawed frog
(Xenopus laevis)
Amphibia adss-prov 36
tropical clawed frog
(Silurana tropicalis)
Amphibia adss 36
  • 78.15 (n)
  • 84.68 (a)
MGC75901 36
zebrafish
(Danio rerio)
Actinopterygii adss 36
adss 36
  • 73 (n)
  • 84.84 (a)
adss 37
  • 82 (a)
OneToOne
fruit fly
(Drosophila melanogaster)
Insecta CG17273 37
  • 55 (a)
OneToMany
BcDNA:LD32788 38
  • 62 (a)
worm
(Caenorhabditis elegans)
Secernentea C37H5.6 37
  • 48 (a)
OneToMany
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes ADE12 37
  • 53 (a)
OneToMany
barley
(Hordeum vulgare)
Liliopsida Hv.1873 36
sea squirt
(Ciona savignyi)
Ascidiacea CSA.8281 37
  • 59 (a)
OneToMany
Species with no ortholog for ADSS:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for ADSS Gene

ENSEMBL:
Gene Tree for ADSS (if available)
TreeFam:
Gene Tree for ADSS (if available)

Paralogs for ADSS Gene

Paralogs for ADSS Gene

Selected SIMAP similar genes for ADSS Gene using alignment to 2 proteins:

Pseudogenes.org Pseudogenes for ADSS Gene

genes like me logo Genes that share paralogs with ADSS: view

Variants for ADSS Gene

Sequence variations from dbSNP and Humsavar for ADSS Gene

SNP ID Clin Chr 01 pos Sequence Context AA Info Type MAF
rs1131837 -- 244,451,743(-) CGGCC(C/G)GGAGG reference, synonymous-codon
rs2068956 -- 244,438,186(+) TGATG(C/T)AAATA intron-variant
rs2306084 -- 244,409,728(-) ATACT(G/T)AGAAA intron-variant
rs3003211 -- 244,449,682(-) TTTAA(A/G)AGTGT intron-variant
rs3003212 -- 244,448,950(-) GGTCA(C/T)TCATC intron-variant

Structural Variations from Database of Genomic Variants (DGV) for ADSS Gene

Variant ID Type Subtype PubMed ID
nsv833115 CNV Gain 17160897
nsv516557 CNV Gain 19592680

Relevant External Links for ADSS Gene

HapMap Linkage Disequilibrium report
ADSS

Disorders for ADSS Gene

(1) MalaCards Diseases for ADSS Gene

Search for ADSS Gene in MalaCards »

(2) University of Copenhagen DISEASES for ADSS Gene

Relevant External Links for ADSS

Genetic Association Database (GAD)
ADSS
Human Genome Epidemiology (HuGE) Navigator
ADSS
genes like me logo Genes that share disorders with ADSS: view

No data available for UniProtKB/Swiss-Prot for ADSS Gene

Publications for ADSS Gene

  1. Cloning and characterization of the cDNA encoding human adenylosuccinate synthetase. (PMID: 1592113) Powell S.M. … Dixon J.E. (FEBS Lett. 1992) 2 3 4 23
  2. A gene correcting the defect in the CHO mutant Ade -H, deficient in a branch point enzyme (adenylosuccinate synthetase) of de novo purine biosynthesis, is located on the long arm of chromosome 1. (PMID: 2004783) Lai L.W. … Patterson D. (Genomics 1991) 2 3 23
  3. An association study of ADSS gene polymorphisms with schizophrenia. (PMID: 18721483) Zhang F. … Liu P. (Behav Brain Funct 2008) 3 23 49
  4. Association analyses of the interaction between the ADSS and ATM genes with schizophrenia in a Chinese population. (PMID: 19115993) Zhang F. … Sham P.C. (BMC Med. Genet. 2008) 3 23 49
  5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4

Products for ADSS Gene

Sources for ADSS Gene

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