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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

ADSS Gene

protein-coding   GIFtS: 65
GCID: GC01M244571

adenylosuccinate synthase

 Explore 8 diseases affiliated with
ADSS via our new
 Human Malady Compendium 
Biological research products
for ADSS
    

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, and/or 10fRNAdb)
About This Section

Aliases
Adenylosuccinate Synthase1 2     L-Type Adenylosuccinate Synthetase2 3
Adenylosuccinate Synthetase, Acidic Isozyme2 3     EC 6.3.4.43 8
Adenylosuccinate Synthetase, Liver Isozyme2 3     ADEH2
AdSS 22 3     Adenylosuccinate Synthetase (Ade(-)H-Complementing)2
AMPSase 22 3     Adenylosuccinate Synthetase Isozyme 22
IMP--Aspartate Ligase 22 3     ADSS23

External Ids:    HGNC: 2921   Entrez Gene: 1592   Ensembl: ENSG000000356877   OMIM: 1030605   UniProtKB: P305203   

Export aliases for ADSS gene to outside databases

Previous GC identifers: GC01M242457 GC01M239817 GC01M240773 GC01M241518 GC01M240897 GC01M242638 GC01M214954


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for ADSS:
This gene encodes the enzyme adenylosuccinate synthetase which catalyzes the first committed step in the conversion of
inosine monophosphate to adenosine monophosphate. A pseudogene of this gene is found on chromosome 17.(provided by
RefSeq, Nov 2010)

UniProtKB/Swiss-Prot: PURA2_HUMAN, P30520
Function: Plays an important role in the de novo pathway and in the salvage pathway of purine nucleotide biosynthesis.
Catalyzes the first committed step in the biosynthesis of AMP from IMP




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000001.10  NC_018912.1  NT_167186.1  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the ADSS gene promoter:
         USF1   Pax-5   NRSF form 1   USF2   CUTL1   NRSF form 2   Roaz   FOXC1   STAT3   IRF-7A   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidADSS promoter sequence
   Search SABiosciences Chromatin IP Primers for ADSS

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat ADSS


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 1q44   Ensembl cytogenetic band:  1q44   HGNC cytogenetic band: 1q44

ADSS Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
ADSS gene location

GeneLoc information about chromosome 1         GeneLoc Exon Structure

GeneLoc location for GC01M244571:  view genomic region     (about GC identifiers)

Start:
244,571,796 bp from pter      End:
244,615,436 bp from pter
Size:
43,641 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to 2PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section

UniProtKB/Swiss-Prot: PURA2_HUMAN, P30520 (See protein sequence)
Recommended Name: Adenylosuccinate synthetase isozyme 2  
Size: 456 amino acids; 50097 Da
Cofactor: Binds 1 magnesium ion per subunit (By similarity)
Subunit: Homodimer (By similarity)
Subcellular location: Cytoplasm. Note=Partially associated with particulate fractions
1 PDB 3D structure from and Proteopedia for ADSS:
2V40 (3D)    
Secondary accessions: B1AQM5 Q96EG7

Explore the universe of human proteins at neXtProt for ADSS: NX_P30520

Post-translational modifications:

  • View modification sites using PhosphoSitePlus2
  • View neXtProt modification sites for NX_P30520

  • 4/20 DME Specific Peptides for ADSS (P30520) (see all 20)
     RRCGWLD  GDEGKGK  QWGDEGK  NAGHTVV 

    ADSS Protein expression data from MOPED and PaxDb:    About this image 
    Estimated protein expression log10 (pmol).

    REFSEQ proteins: NP_001117.2  
    ENSEMBL proteins: 
     ENSP00000355493  
    Reactome Protein details: P30520
    Human Recombinant Protein Products: 
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    Novus Biologicals ADSS Lysate
    Browse Sino Biological Recombinant Proteins
    Browse ProSpec Recombinant Proteins
    Uscn Proteins for ADSS

    Gene Ontology (GO): 3 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005737cytoplasm IDA--
    GO:0005829cytosol TAS--
    GO:0005886plasma membrane IDA--


    ADSS for ontologies           About GeneDecksing



    ADSS Antibody Products: 
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    Uscn ELISAs and CLIAs for ADSS


    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section

    ADSS for domains           About GeneDecksing

    2 InterPro domains/families:
     IPR018220 Adenylosuccinate_synthase_AS
     IPR001114 Adenylosuccinate_synthetase

    Graphical View of Domain Structure for InterPro Entry P30520

    ProtoNet protein and cluster: P30520

    1 Blocks protein family: IPB001114 Adenylosuccinate synthetase

    UniProtKB/Swiss-Prot: PURA2_HUMAN, P30520
    Similarity: Belongs to the adenylosuccinate synthetase family


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
    About This Section

    Function Summary:

         UniProtKB/Swiss-Prot: PURA2_HUMAN, P30520
    Function: Plays an important role in the de novo pathway and in the salvage pathway of purine nucleotide biosynthesis.
    Catalyzes the first committed step in the biosynthesis of AMP from IMP
    Catalytic activity: GTP + IMP + L-aspartate = GDP + phosphate + N(6)-(1,2-dicarboxyethyl)-AMP

         Genatlas biochemistry entry for ADSS:
    adenylosuccinate synthase,purine nucleotide cycle

    Enzyme Number (IUBMB): EC 6.3.4.41 2

    miRNA
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    Browse MicroRNA Expression Plasmids
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat ADSS
    8/10 QIAGEN miScript miRNA Assays for microRNAs that regulate ADSS (see all 10):
    hsa-miR-548a-3p hsa-miR-217 hsa-miR-659 hsa-miR-19b hsa-miR-1323 hsa-miR-593* hsa-miR-548e hsa-miR-548o
    SwitchGear 3'UTR luciferase reporter plasmidADSS 3' UTR sequence
    Inhib. RNA
    Products:
        
    Browse for Gene Knock-down Tools from EMD Millipore
    OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for ADSS (see all 6)
    OriGene siRNA: ADSS
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    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat ADSS 

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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ADSS

    Gene Ontology (GO): 4 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000287magnesium ion binding IEA--
    GO:0004019adenylosuccinate synthase activity NAS1592113
    GO:0005525GTP binding NAS1592113
    GO:0042301phosphate ion binding NAS1592113


    ADSS for ontologies           About GeneDecksing


    2 GenomeRNAi human phenotypes for ADSS:
     Cell cycle / mitosis defect  Upregulation of Wnt/beta-caten 


    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
    About This Section

    Unified GeneCards pathways - 5/7 super-pathways (see all 7About this table 
    See pathways by source

    Super-pathwaycontained gene-specific pathways
    1Purine metabolism
    Purine metabolism1.00
    Metabolism of nucleotides0.42
    2purine nucleotides de novo biosynthesis II
    purine nucleotides de novo biosynthesis II1.00
    Purine ribonucleoside monophosphate biosynthesis0.91
    3Metabolism
    Metabolism1.00
    Metabolic pathways0.38
    4ATP/ITP metabolism
    ATP/ITP metabolism1.00
    ATP/ITP metabolism0.98
    5Nucleotide Metabolism
    Nucleotide Metabolism1.00

    Pathway sources
    See GeneCards unified pathways
    Show all pathways

    1 EMD Millipore Pathway for ADSS
        ATP/ITP metabolism


    1 GeneGo (Thomson Reuters) Pathway for ADSS
        ATP/ITP metabolism

    2 BioSystems Pathways for ADSS 
        Nucleotide Metabolism
    purine nucleotides de novo biosynthesis II

    4        Reactome Pathways for ADSS
        Metabolism of nucleotides
    Metabolism
    Purine ribonucleoside monophosphate biosynthesis
    Purine metabolism


    3         Kegg Pathways  (Kegg details for ADSS):
        Purine metabolism
    Alanine, aspartate and glutamate metabolism
    Metabolic pathways

    UniProtKB/Swiss-Prot: PURA2_HUMAN, P30520
    Pathway: Purine metabolism; AMP biosynthesis via de novo pathway; AMP from IMP: step 1/2


    ADSS for pathways           About GeneDecksing

    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for ADSS

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    5/65 Interacting proteins for ADSS (P305203 ENSP000003554934) via UniProtKB, MINT, STRING, and/or I2D (see all 65)

    InteractantInteraction Details
    GeneCardExternal ID(s)
    HLA-BP304803, ENSP000003991684I2D: score=1 STRING: ENSP00000399168
    ACTA1P681333, ENSP000003556454I2D: score=1 STRING: ENSP00000355645
    ATG10Q9H0Y03, ENSP000002821854I2D: score=2 STRING: ENSP00000282185
    DDA1Q9BW613I2D: score=1 
    GBASO753233I2D: score=1 
    About this table

    Gene Ontology (GO): 5/14 biological process terms (GO ID links to tree view) (see all 14):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0002376immune system process NAS15786719
    GO:0006144purine nucleobase metabolic process TAS--
    GO:0006164purine nucleotide biosynthetic process ----
    GO:0006167AMP biosynthetic process NAS1592113
    GO:0006184GTP catabolic process IEA--


    ADSS for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section

    ADSS for compounds           About GeneDecksing

    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for ADSS

    7 HMDB Compounds for ADSS    About this table
    CompoundSynonyms CAS #PubMed Ids
    Adenylsuccinic acid6-Succino-5'-adenylate (see all 14)19046-78-7--
    Guanosine diphosphate5'-GDP (see all 10)146-91-8--
    Guanosine triphosphate5'-GTP (see all 10)86-01-1--
    Inosinic acid5'-IMP (see all 9)131-99-7--
    L-Aspartic acid(+)-Aspartate (see all 41)56-84-8--
    MagnesiumMagnesium (see all 2)7439-95-4--
    PhosphateNFB Orthophosphate (see all 13)14265-44-2--

    1 DrugBank Compound for ADSS    About this table
    CompoundSynonyms CAS #TypeActionsPubMed Ids
    L-Aspartic Acid(+)-Aspartic acid (see all 23)56-84-8target--17139284 2544615 17016423 6703692 1657607

    10 Novoseek chemical compound relationships for ADSS gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    adenylosuccinate 98.6 66 9486871 (3), 10218106 (3), 8757283 (3), 8790347 (3) (see all 33)
    hadacidin 90.6 2 1657607 (1)
    l-alanosine 86.6 4 7825060 (2), 16778103 (1)
    prpp 77.6 6 8207962 (1), 16204483 (1), 10597272 (1), 15566465 (1)
    purine 72.9 9 8207962 (1), 2004783 (1), 1807901 (1), 1529104 (1) (see all 8)
    gtp 56.2 4 1939181 (1), 10218106 (1), 9218429 (1)
    aspartate 48.9 4 16981730 (1), 10597272 (1), 1657607 (1), 9218429 (1)
    adenine 41.3 1 2004783 (1)
    adenylate 36.7 2 9486871 (1), 8790347 (1)
    atp 28.8 1 1657607 (1)

    Search CenterWatch for drugs/clinical trials and news about ADSS / PURA2 

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for ADSS gene: 
    NM_001126.3  

    Unigene Cluster for ADSS:

    Adenylosuccinate synthase
    Hs.498313  [show with all ESTs]
    Unigene Representative Sequence: NM_001126
    3 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000366535(uc001iaj.3 uc009xgr.2) ENST00000468215 ENST00000462358


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    8/10 QIAGEN miScript miRNA Assays for microRNAs that regulate ADSS (see all 10):
    hsa-miR-548a-3p hsa-miR-217 hsa-miR-659 hsa-miR-19b hsa-miR-1323 hsa-miR-593* hsa-miR-548e hsa-miR-548o
    SwitchGear 3'UTR luciferase reporter plasmidADSS 3' UTR sequence
    Inhib. RNA
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    Additional cDNA sequence: 

    AK025514.1 AK303886.1 AK308749.1 BC012356.1 

    14 DOTS entries:

    DT.418616  DT.100015261  DT.75106335  DT.91749155  DT.121461357  DT.95153819  DT.95331535  DT.120912379 
    DT.121461371  DT.121461372  DT.91749156  DT.95331537  DT.95342256  DT.403819 

    24/221 AceView cDNA sequences (see all 221):

    BF108765 AA665826 BM799201 AI282175 AI570934 NM_001126 AA158988 BM984527 
    AW945158 D58279 AU133215 AI302318 CR626347 BQ288009 AU131151 AL599492 
    CD105193 CA420638 AU121367 AA662499 CD722468 AL133783 AI003966 BQ574089 

    GeneLoc Exon Structure

    5/6 Alternative Splicing Database (ASD) splice patterns (SP) for ADSS (see all 6)    About this scheme

    ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8a · 8b ^ 9a · 9b ^ 10 ^ 11 ^ 12 ^ 13a · 13b ^ 14 ^ 15a · 15b ^ 16
    SP1:        -                 -           -     -                                         -                       -         
    SP2:        -                             -     -                                                                           
    SP3:        -                 -                                                                                             
    SP4:                                                                                                                        
    SP5:                                                                                                                        


    ECgene alternative splicing isoforms for ADSS

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    ADSS expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS
    CGAP TAG: AATAGCTGAT

    Microarray
    RNAseq (Illumina Body Map)
    (100×FPKM)½
    SAGE (Serial Analysis of Gene Expression)

    About this image
    See ADSS Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for ADSS

    SOURCE GeneReport for Unigene cluster: Hs.498313
        SABiosciences Expression via Pathway-Focused PCR Array including ADSS: 
              Amino Acid Metabolism II in human mouse rat

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    In Situ
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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the last universal common ancestor (LUCA).

    Orthologs for ADSS gene from 9/35 species (see all 35)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    chicken
    (Gallus gallus)
    Aves ADSS1 adenylosuccinate synthase 81.19(n)
    90.44(a)
      428579  NM_001031521.1  NP_001026692.1 
    lizard
    (Anolis carolinensis)
    Reptilia ADSS6
    --
    88(a)
    1 ↔ 1
    GL343285.1(964065-999078)
    African clawed frog
    (Xenopus laevis)
    Amphibia adss-prov2 adenylosuccinate synthetase 2, non muscle 77.91(n)    BC043896.1 
    zebrafish
    (Danio rerio)
    Actinopterygii adss2 adenylosuccinate synthase 73.57(n)   192305  AY099534.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta BcDNA:LD327883
    CG172731
    purine nucleotide biosynthesis
    adenylosuccinate more3
    CG172731
    62(a)3
    57.82(n)1
    64.22(a)1
      93A13
    424661  NM_142661.21  NP_650918.11 
    worm
    (Caenorhabditis elegans)
    Secernentea C37H5.61 Protein C37H5.6 55.5(n)
    55.5(a)
      178872  NM_171450.1  NP_741529.1 
    thale cress
    (Arabidopsis thaliana)
    eudicotyledons ADSS1 adenylosuccinate synthetase 53.48(n)
    51.08(a)
      824930  NM_115621.4  NP_191320.1 
    rice
    (Oryza sativa)
    Liliopsida AK120407.12   -- 76.22(n)    AK120407.1 
    E. coli
    (Escherichia coli)
    Gamma proteobacteria purA6
    adenylosuccinate synthetase
    41(a)
    1 → many
    Chromosome(4402710-4404008)


    ENSEMBL Gene Tree for ADSS (if available)
    TreeFam Gene Tree for ADSS (if available) 

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for ADSS gene
    ADSSL12  
    1 SIMAP similar gene for ADSS using alignment to 1 protein entry:     PURA2_HUMAN:
    ADSSL1

    ADSS for paralogs           About GeneDecksing


    1 Pseudogenes.org Pseudogene for ADSS
    PGOHUM00000237034


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/711 NCBI SNPs in ADSS are shown (see all 711    About this table
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 1 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs791950601,2
    --244571316(+) TACTGC/TAGCAT 1 -- ds50011Minor allele frequency- T:0.01WA 118
    rs1447724971,2
    --244571425(+) ACCTA-/GGAAGA 1 -- ds50010--------
    rs1441172531,2
    --244571537(+) AGAATA/GCAGAC 1 -- ds50010--------
    rs1900827931,2
    --244571711(+) GAACTA/TAGTAT 1 -- ds50010--------
    rs1457385801,2
    --244571721(+) TTACAC/GTACAG 1 -- ds50010--------
    rs1155235081,2
    --244571814(+) TGGTTC/ATTTTA 1 -- ut311Minor allele frequency- A:0.01NA 120
    rs1418206991,2
    C,--244571936(+) ACACC-/TTTTTT 1 -- ut310--------
    rs610847831,2
    C--244571937(+) TTTTT-/TCAAGA 1 -- ut310--------
    rs1835956221,2
    --244572352(+) TTTCAC/GCAGAA 1 -- ut310--------
    rs1886433541,2
    --244572366(+) AGACAC/GCCCAA 1 -- ut310--------

    HapMap Linkage Disequilibrium report for ADSS (244571796 - 244615436 bp)
    Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
    Database of Genomic Variants (DGV): 3 variations for ADSS
         1 CNV: 84952
         2 Indels: 84953 74965

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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section

    ADSS for disorders           About GeneDecksing

    OMIM gene information: 103060    OMIM disorders: --

    8 diseases for ADSS:    About MalaCards
    relapsing fever    mantle cell lymphoma    pneumonia    schizophrenia
    tuberculosis    immunodeficiency    malaria    mycobacterium tuberculosis

    1 disease from the University of Copenhagen DISEASES database for ADSS:
    Herpes simplex
    Human Genome Epidemiology (HuGE) Navigator: ADSS (2 documents)

    Export disorders for ADSS gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for ADSS gene, integrated from 9 sources (see all 56):
    (articles sorted by number of sources associating them with ADSS)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Cloning and characterization of the cDNA encoding human adenylosuccinate synthetase. (PubMed id 1592113)1, 2, 3, 9 Powell S.M.... Dixon J.E. (1992)
    2. A gene correcting the defect in the CHO mutant Ade -H, deficient in a branch point enzyme (adenylosuccinate synthetase) of de novo purine biosynthesis, is located on the long arm of chromosome 1. (PubMed id 2004783)1, 3, 9 Lai L.W....Patterson D. (1991)
    3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    4. Association analyses of the interaction between the ADSS and ATM genes with schizophrenia in a Chinese population. (PubMed id 19115993)1, 9 Zhang F....Sham P.C. (2008)
    5. An association study of ADSS gene polymorphisms with schizophrenia. (PubMed id 18721483)1, 9 Zhang F....Liu P. (2008)
    6. Molecular cloning and characterization of a novel muscle adenylosuccinate synthetase, AdSSL1, from human bone marrow stromal cells. (PubMed id 15786719)1, 9 Sun H....Cao X. (2005)
    7. Inhibition of adenine nucleotide synthesis: effect on tight junction structure and function of clone 4 MDCK cells. (PubMed id 1657607)7, 9 Ladino C....Lynch R.D. (1991)
    8. A census of human soluble protein complexes. (PubMed id 22939629)1 Havugimana P.C....Emili A. (2012)
    9. Methods for quantification of in vivo changes in prote in ubiquitination following proteasome and deubiquitinase inhibition. (PubMed id 22505724)1 Udeshi N.D....Carr S.A. (2012)
    10. A high-throughput approach for measuring temporal chan ges in the interactome. (PubMed id 22863883)1 Kristensen A.R....Foster L.J. (2012)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Free Text  

      Query String
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    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 159 HGNC: 292 AceView: ADSS Ensembl:ENSG00000035687 euGenes: HUgn159
    ECgene: ADSS Kegg: 159 H-InvDB: ADSS

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for ADSS Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for ADSS gene:
    Search GeneIP for patents involving ADSS

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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