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Aliases for ADRM1 Gene

Aliases for ADRM1 Gene

  • Adhesion Regulating Molecule 1 2 3 5
  • Proteasome Regulatory Particle Non-ATPase 13 3 4
  • 110 KDa Cell Membrane Glycoprotein 3 4
  • Rpn13 Homolog 3 4
  • ARM-1 3 4
  • GP110 3 4
  • Adhesion-Regulating Molecule 1 4
  • M(R) 110,000 Surface Antigen 3
  • HRpn13 4
  • ARM1 3

External Ids for ADRM1 Gene

Previous GeneCards Identifiers for ADRM1 Gene

  • GC20P060641
  • GC20P061516
  • GC20P061563
  • GC20P060311
  • GC20P060877
  • GC20P057653

Summaries for ADRM1 Gene

Entrez Gene Summary for ADRM1 Gene

  • This gene encodes a member of the adhesion regulating molecule 1 protein family. The encoded protein is a component of the proteasome where it acts as a ubiquitin receptor and recruits the deubiquitinating enzyme, ubiquitin carboxyl-terminal hydrolase L5. Increased levels of the encoded protein are associated with increased cell adhesion, which is likely an indirect effect of this intracellular protein. Dysregulation of this gene has been implicated in carcinogenesis. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2013]

GeneCards Summary for ADRM1 Gene

ADRM1 (Adhesion Regulating Molecule 1) is a Protein Coding gene. GO annotations related to this gene include protease binding and endopeptidase activator activity.

UniProtKB/Swiss-Prot for ADRM1 Gene

  • Functions as a proteasomal ubiquitin receptor. Recruits the deubiquitinating enzyme UCHL5 at the 26S proteasome and promotes its activity.

Gene Wiki entry for ADRM1 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ADRM1 Gene

Genomics for ADRM1 Gene

Regulatory Elements for ADRM1 Gene

Enhancers for ADRM1 Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around ADRM1 on UCSC Golden Path with GeneCards custom track

Promoters for ADRM1 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around ADRM1 on UCSC Golden Path with GeneCards custom track

Genomic Location for ADRM1 Gene

Chromosome:
20
Start:
62,302,056 bp from pter
End:
62,308,862 bp from pter
Size:
6,807 bases
Orientation:
Plus strand

Genomic View for ADRM1 Gene

Genes around ADRM1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ADRM1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ADRM1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ADRM1 Gene

Proteins for ADRM1 Gene

  • Protein details for ADRM1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q16186-ADRM1_HUMAN
    Recommended name:
    Proteasomal ubiquitin receptor ADRM1
    Protein Accession:
    Q16186
    Secondary Accessions:
    • A0PKB1
    • Q96FJ7
    • Q9H1P2

    Protein attributes for ADRM1 Gene

    Size:
    407 amino acids
    Molecular mass:
    42153 Da
    Quaternary structure:
    • Interacts with PSMD1, ubiquitin and UCHL5.

    Three dimensional structures from OCA and Proteopedia for ADRM1 Gene

neXtProt entry for ADRM1 Gene

Proteomics data for ADRM1 Gene at MOPED

Post-translational modifications for ADRM1 Gene

  • Ubiquitination at Lys 21, Lys 34, Lys 62, and Lys 379
  • Modification sites at PhosphoSitePlus

Other Protein References for ADRM1 Gene

Antibody Products

  • Cell Signaling Technology (CST) Antibodies for ADRM1 (ADRM1)
  • Cloud-Clone Corp. Antibodies for ADRM1

No data available for DME Specific Peptides for ADRM1 Gene

Domains & Families for ADRM1 Gene

Protein Domains for ADRM1 Gene

Suggested Antigen Peptide Sequences for ADRM1 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q16186

UniProtKB/Swiss-Prot:

ADRM1_HUMAN :
  • The PH domain mediates interactions with PSMD1 and ubiquitin. Preferential binding to the proximal subunit of K48-linked diubiquitin allows UCHL5 access to the distal subunit (By similarity).
  • Belongs to the ADRM1 family.
Domain:
  • The PH domain mediates interactions with PSMD1 and ubiquitin. Preferential binding to the proximal subunit of K48-linked diubiquitin allows UCHL5 access to the distal subunit (By similarity).
  • Contains 1 PH domain.
Family:
  • Belongs to the ADRM1 family.
genes like me logo Genes that share domains with ADRM1: view

No data available for Gene Families for ADRM1 Gene

Function for ADRM1 Gene

Molecular function for ADRM1 Gene

UniProtKB/Swiss-Prot Function:
Functions as a proteasomal ubiquitin receptor. Recruits the deubiquitinating enzyme UCHL5 at the 26S proteasome and promotes its activity.

Gene Ontology (GO) - Molecular Function for ADRM1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 16713569
GO:0061133 endopeptidase activator activity IDA 16990800
genes like me logo Genes that share ontologies with ADRM1: view
genes like me logo Genes that share phenotypes with ADRM1: view

Animal Model Products

  • Taconic Biosciences Mouse Models for ADRM1

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for ADRM1 Gene

Localization for ADRM1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ADRM1 Gene

Cytoplasm. Nucleus.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for ADRM1 Gene COMPARTMENTS Subcellular localization image for ADRM1 gene
Compartment Confidence
nucleus 5
plasma membrane 5
cytosol 3
extracellular 1
mitochondrion 1
peroxisome 1

Gene Ontology (GO) - Cellular Components for ADRM1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005654 nucleoplasm IDA --
GO:0005737 cytoplasm IEA,IDA --
GO:0005887 integral component of plasma membrane TAS 8033103
GO:0016020 membrane TAS 8033103
genes like me logo Genes that share ontologies with ADRM1: view

Drugs & Compounds for ADRM1 Gene

No Compound Related Data Available

Transcripts for ADRM1 Gene

Unigene Clusters for ADRM1 Gene

Adhesion regulating molecule 1:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for ADRM1 Gene

ExUns: 1 ^ 2a · 2b · 2c · 2d ^ 3a · 3b · 3c ^ 4a · 4b · 4c ^ 5 ^ 6a · 6b ^ 7a · 7b ^ 8 ^ 9 ^ 10a · 10b · 10c ^ 11 ^ 12 ^ 13a · 13b · 13c ·
SP1: - - - - -
SP2: - - - - -
SP3: - - - -
SP4: - - - - - - - -
SP5: - - - - -
SP6: - - - - - -
SP7: - - - -
SP8: - -
SP9: - - - - - - - - - - - - - - -
SP10: -
SP11: - - - -
SP12: -
SP13: -

ExUns: 13d
SP1:
SP2:
SP3:
SP4:
SP5:
SP6:
SP7:
SP8:
SP9:
SP10:
SP11:
SP12:
SP13:

Relevant External Links for ADRM1 Gene

GeneLoc Exon Structure for
ADRM1
ECgene alternative splicing isoforms for
ADRM1

Expression for ADRM1 Gene

mRNA expression in normal human tissues for ADRM1 Gene

mRNA differential expression in normal tissues according to GTEx for ADRM1 Gene

This gene is overexpressed in Muscle - Skeletal (x4.6).

Protein differential expression in normal tissues from HIPED for ADRM1 Gene

This gene is overexpressed in Peripheral blood mononuclear cells (7.6), Breast (7.5), and Bone (6.1).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for ADRM1 Gene



SOURCE GeneReport for Unigene cluster for ADRM1 Gene Hs.90107

genes like me logo Genes that share expression patterns with ADRM1: view

Protein tissue co-expression partners for ADRM1 Gene

- Elite partner

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and mRNA Expression by UniProt/SwissProt for ADRM1 Gene

Orthologs for ADRM1 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for ADRM1 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia ADRM1 35
  • 88.62 (n)
  • 96.81 (a)
ADRM1 36
  • 97 (a)
OneToOne
dog
(Canis familiaris)
Mammalia ADRM1 35
  • 89.24 (n)
  • 96.55 (a)
ADRM1 36
  • 97 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Adrm1 35
  • 87.31 (n)
  • 96.56 (a)
Adrm1 16
Adrm1 36
  • 97 (a)
OneToMany
Gm9774 36
  • 90 (a)
OneToMany
chimpanzee
(Pan troglodytes)
Mammalia ADRM1 35
  • 96.34 (n)
  • 95.26 (a)
ADRM1 36
  • 100 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Adrm1 35
  • 87.47 (n)
  • 96.56 (a)
oppossum
(Monodelphis domestica)
Mammalia ADRM1 36
  • 92 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia ADRM1 36
  • 91 (a)
OneToOne
chicken
(Gallus gallus)
Aves ADRM1 35
  • 78.9 (n)
  • 89.9 (a)
ADRM1 36
  • 90 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia ADRM1 36
  • 85 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia adrm1 35
  • 76.51 (n)
  • 88.09 (a)
MGC75897 35
African clawed frog
(Xenopus laevis)
Amphibia Xoom 35
zebrafish
(Danio rerio)
Actinopterygii adrm1 35
  • 74.8 (n)
  • 88.69 (a)
zgc56107 35
adrm1 36
  • 78 (a)
OneToOne
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.8622 35
fruit fly
(Drosophila melanogaster)
Insecta CG13349 37
  • 66 (a)
CG13349 36
  • 41 (a)
OneToMany
CG6789 36
  • 35 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea C56G2.7 37
  • 32 (a)
C56G2.7 36
  • 36 (a)
OneToOne
thale cress
(Arabidopsis thaliana)
eudicotyledons RPN13 35
  • 47.86 (n)
  • 43.96 (a)
rice
(Oryza sativa)
Liliopsida Os05g0594800 35
  • 46.57 (n)
  • 41.2 (a)
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.4565 35
fission yeast
(Schizosaccharomyces pombe)
Schizosaccharomycetes rpn1301 35
  • 44.85 (n)
  • 37.33 (a)
sea squirt
(Ciona savignyi)
Ascidiacea CSA.8586 36
  • 51 (a)
OneToOne
Species with no ortholog for ADRM1:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for ADRM1 Gene

ENSEMBL:
Gene Tree for ADRM1 (if available)
TreeFam:
Gene Tree for ADRM1 (if available)

Paralogs for ADRM1 Gene

(1) SIMAP similar genes for ADRM1 Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with ADRM1: view

No data available for Paralogs for ADRM1 Gene

Variants for ADRM1 Gene

Sequence variations from dbSNP and Humsavar for ADRM1 Gene

SNP ID Clin Chr 20 pos Sequence Context AA Info Type
rs2018659 -- 62,301,662(-) CCTTC(G/T)CAAAA upstream-variant-2KB
rs6062204 -- 62,300,181(+) ttgca(A/G)gtgtg upstream-variant-2KB
rs6062205 -- 62,301,703(+) AGTGG(C/T)GCAAT upstream-variant-2KB
rs6062206 -- 62,302,667(+) GGGTG(C/G)GCTCG intron-variant, upstream-variant-2KB, utr-variant-5-prime
rs6062207 -- 62,304,172(+) AGTTC(A/G)GCGTT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for ADRM1 Gene

Variant ID Type Subtype PubMed ID
dgv4599n71 CNV Loss 21882294
dgv4601n71 CNV Loss 21882294
nsv518296 CNV Loss 19592680
nsv913047 CNV Loss 21882294
esv2422398 CNV Duplication 17116639
nsv470556 CNV Loss 18288195
nsv834024 CNV Gain 17160897
nsv913048 CNV Loss 21882294
dgv4602n71 CNV Loss 21882294
nsv913052 CNV Gain 21882294
nsv913053 CNV Gain+Loss 21882294
dgv4603n71 CNV Loss 21882294
nsv913056 CNV Loss 21882294
nsv3441 CNV Insertion 18451855
dgv4604n71 CNV Loss 21882294
nsv913059 CNV Loss 21882294

Variation tolerance for ADRM1 Gene

Residual Variation Intolerance Score: 27.1% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 3.20; 52.16% of all genes are more intolerant (likely to be disease-causing)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Relevant External Links for ADRM1 Gene

Disorders for ADRM1 Gene

Relevant External Links for ADRM1

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
ADRM1

No disorders were found for ADRM1 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for ADRM1 Gene

Publications for ADRM1 Gene

  1. Molecular cloning and characterization of the complementary DNA of an M(r) 110,000 antigen expressed by human gastric carcinoma cells and upregulated by gamma-interferon. (PMID: 8033103) Shimada S. … Greiner J.W. (Cancer Res. 1994) 2 3 4 67
  2. MxA interacts with and is modified by the SUMOylation machinery. (PMID: 25447205) Brantis-de-Carvalho C.E. … Valentini S.R. (Exp. Cell Res. 2015) 3
  3. The E3 ubiquitin ligase parkin is recruited to the 26 S proteasome via the proteasomal ubiquitin receptor Rpn13. (PMID: 25666615) Aguileta M.A. … Husnjak K. (J. Biol. Chem. 2015) 3
  4. Mechanism of UCH-L5 activation and inhibition by DEUBAD domains in RPN13 and INO80G. (PMID: 25702870) Sahtoe D.D. … Sixma T.K. (Mol. Cell 2015) 3
  5. Structural basis for the activation and inhibition of the UCH37 deubiquitylase. (PMID: 25702872) VanderLinden R.T. … Hill C.P. (Mol. Cell 2015) 3

Products for ADRM1 Gene

Sources for ADRM1 Gene

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