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Aliases for ADRBK2 Gene

Aliases for ADRBK2 Gene

  • Adrenergic, Beta, Receptor Kinase 2 2 3
  • BARK2 3 4 6
  • GRK3 3 4 6
  • G-Protein-Coupled Receptor Kinase 3 3 4
  • EC 2.7.11.15 4 64
  • Beta-ARK-2 3 4
  • Beta-Adrenergic Receptor Kinase 2 3
  • EC 2.7.11 64

External Ids for ADRBK2 Gene

Summaries for ADRBK2 Gene

Entrez Gene Summary for ADRBK2 Gene

  • The beta-adrenergic receptor kinase specifically phosphorylates the agonist-occupied form of the beta-adrenergic and related G protein-coupled receptors. Overall, the beta adrenergic receptor kinase 2 has 85% amino acid similarity with beta adrenergic receptor kinase 1, with the protein kinase catalytic domain having 95% similarity. These data suggest the existence of a family of receptor kinases which may serve broadly to regulate receptor function. [provided by RefSeq, Jul 2008]

GeneCards Summary for ADRBK2 Gene

ADRBK2 (Adrenergic, Beta, Receptor Kinase 2) is a Protein Coding gene. Diseases associated with ADRBK2 include whim syndrome. Among its related pathways are Endocytosis and Chemokine Signaling. GO annotations related to this gene include phospholipid binding and G-protein coupled receptor kinase activity. An important paralog of this gene is AKT1.

UniProtKB/Swiss-Prot for ADRBK2 Gene

  • Specifically phosphorylates the agonist-occupied form of the beta-adrenergic and closely related receptors

Gene Wiki entry for ADRBK2 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ADRBK2 Gene

Genomics for ADRBK2 Gene

Genomic Location for ADRBK2 Gene

Start:
25,564,849 bp from pter
End:
25,729,294 bp from pter
Size:
164,446 bases
Orientation:
Plus strand

Genomic View for ADRBK2 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for ADRBK2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ADRBK2 Gene

Regulatory Elements for ADRBK2 Gene

Proteins for ADRBK2 Gene

  • Protein details for ADRBK2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P35626-ARBK2_HUMAN
    Recommended name:
    Beta-adrenergic receptor kinase 2
    Protein Accession:
    P35626
    Secondary Accessions:
    • Q9UGW9

    Protein attributes for ADRBK2 Gene

    Size:
    688 amino acids
    Molecular mass:
    79710 Da
    Quaternary structure:
    No Data Available

neXtProt entry for ADRBK2 Gene

Proteomics data for ADRBK2 Gene at MOPED

Post-translational modifications for ADRBK2 Gene

Other Protein References for ADRBK2 Gene

ENSEMBL proteins:
REFSEQ proteins:

Domains for ADRBK2 Gene

Gene Families for ADRBK2 Gene

UniProtKB/Swiss-Prot:

ARBK2_HUMAN
Domain:
  • Contains 1 AGC-kinase C-terminal domain.:
    • P35626
  • Contains 1 PH domain.:
    • P35626
  • Contains 1 protein kinase domain.:
    • P35626
  • Contains 1 RGS domain.:
    • P35626
Family:
  • Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. GPRK subfamily.:
    • P35626
genes like me logo Genes that share domains with ADRBK2: view

Function for ADRBK2 Gene

Molecular function for ADRBK2 Gene

GENATLAS Biochemistry: beta-adrenergic receptor kinase 2
UniProtKB/Swiss-Prot CatalyticActivity: ATP + [beta-adrenergic receptor] = ADP + [beta-adrenergic receptor] phosphate
UniProtKB/Swiss-Prot Function: Specifically phosphorylates the agonist-occupied form of the beta-adrenergic and closely related receptors

Enzyme Numbers (IUBMB) for ADRBK2 Gene

Gene Ontology (GO) - Molecular Function for ADRBK2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004672 protein kinase activity TAS 8427589
GO:0004674 protein serine/threonine kinase activity --
GO:0004703 G-protein coupled receptor kinase activity IEA --
GO:0004713 protein tyrosine kinase activity --
GO:0005524 ATP binding IEA --
genes like me logo Genes that share ontologies with ADRBK2: view
genes like me logo Genes that share phenotypes with ADRBK2: view

Animal Models for ADRBK2 Gene

MGI Knock Outs for ADRBK2:

miRNA for ADRBK2 Gene

miRTarBase miRNAs that target ADRBK2

No data available for Transcription Factor Targeting and HOMER Transcription for ADRBK2 Gene

Localization for ADRBK2 Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for ADRBK2 Gene COMPARTMENTS Subcellular localization image for ADRBK2 gene
Compartment Confidence
cytosol 3
nucleus 2
peroxisome 1
plasma membrane 1

No data available for Gene Ontology (GO) - Cellular Components for ADRBK2 Gene

Pathways for ADRBK2 Gene

genes like me logo Genes that share pathways with ADRBK2: view

Pathways by source for ADRBK2 Gene

Gene Ontology (GO) - Biological Process for ADRBK2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006468 protein phosphorylation IEA --
GO:0007165 signal transduction IEA --
GO:0008277 regulation of G-protein coupled receptor protein signaling pathway --
GO:0031623 receptor internalization IDA 20074556
GO:0038032 termination of G-protein coupled receptor signaling pathway IEA --
genes like me logo Genes that share ontologies with ADRBK2: view

Compounds for ADRBK2 Gene

(3) HMDB Compounds for ADRBK2 Gene

Compound Synonyms Cas Number PubMed IDs
Adenosine triphosphate
  • 5'-(tetrahydrogen triphosphate) Adenosine
56-65-5
ADP
  • adenosindiphosphorsaeure
58-64-0
Zinc
  • Zinc
7440-66-6

(1) Drugbank Compounds for ADRBK2 Gene

Compound Synonyms Cas Number Type Actions PubMed IDs
Adenosine triphosphate
  • 5'-ATP
56-65-5 target

(13) Novoseek inferred chemical compound relationships for ADRBK2 Gene

Compound -log(P) Hits PubMed IDs
damgo 48.2 5
geldanamycin 43.9 3
pip2 42.6 2
epinephrine 38.5 11
ionomycin 21.3 1
genes like me logo Genes that share compounds with ADRBK2: view

Transcripts for ADRBK2 Gene

Unigene Clusters for ADRBK2 Gene

Adrenergic, beta, receptor kinase 2:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for ADRBK2 Gene

ExUns: 1 ^ 2 ^ 3 ^ 4a · 4b · 4c ^ 5 ^ 6 ^ 7 ^ 8 ^ 9a · 9b · 9c ^ 10 ^ 11 ^ 12 ^ 13 ^ 14a · 14b ^ 15 ^ 16 ^ 17 ^ 18 ^ 19 ^ 20 ^ 21 ^
SP1: - - - -
SP2:
SP3: -
SP4:

ExUns: 22 ^ 23 ^ 24
SP1:
SP2:
SP3:
SP4:

Relevant External Links for ADRBK2 Gene

GeneLoc Exon Structure for
ADRBK2
ECgene alternative splicing isoforms for
ADRBK2

Expression for ADRBK2 Gene

mRNA expression in normal human tissues for ADRBK2 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for ADRBK2 Gene

SOURCE GeneReport for Unigene cluster for ADRBK2 Gene Hs.657494

genes like me logo Genes that share expressions with ADRBK2: view

Orthologs for ADRBK2 Gene

This gene was present in the common ancestor of animals.

Orthologs for ADRBK2 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia ADRBK2 36
  • 99.27 (n)
  • 99.13 (a)
ADRBK2 37
  • 100 (a)
OneToOne
cow
(Bos Taurus)
Mammalia ADRBK2 36
  • 89.44 (n)
  • 95.49 (a)
ADRBK2 37
  • 95 (a)
OneToOne
dog
(Canis familiaris)
Mammalia ADRBK2 36
  • 89.99 (n)
  • 95.98 (a)
ADRBK2 37
  • 96 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Adrbk2 36
  • 83.14 (n)
  • 91.42 (a)
Adrbk2 16
Adrbk2 37
  • 91 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia ADRBK2 37
  • 91 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia -- 37
  • 93 (a)
ManyToMany
rat
(Rattus norvegicus)
Mammalia Adrbk2 36
  • 83.77 (n)
  • 91.13 (a)
chicken
(Gallus gallus)
Aves ADRBK2 36
  • 82.74 (n)
  • 93.39 (a)
ADRBK2 37
  • 93 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia -- 37
  • 83 (a)
ManyToMany
tropical clawed frog
(Silurana tropicalis)
Amphibia adrbk2 36
  • 82.7 (n)
  • 92.73 (a)
zebrafish
(Danio rerio)
Actinopterygii adrbk2 36
  • 76.26 (n)
  • 90.55 (a)
adrbk2 37
  • 91 (a)
OneToMany
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP012026 36
  • 63.41 (n)
  • 70.68 (a)
fruit fly
(Drosophila melanogaster)
Insecta Gprk1 36
  • 63.19 (n)
  • 68.38 (a)
Gprk1 37
  • 65 (a)
OneToMany
Gprk1 38
  • 66 (a)
worm
(Caenorhabditis elegans)
Secernentea grk-2 36
  • 63.67 (n)
  • 68.04 (a)
grk-2 37
  • 65 (a)
OneToMany
W02B3.2 38
  • 69 (a)
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.3907 36
Species with no ortholog for ADRBK2:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for ADRBK2 Gene

ENSEMBL:
Gene Tree for ADRBK2 (if available)
TreeFam:
Gene Tree for ADRBK2 (if available)

Paralogs for ADRBK2 Gene

Selected SIMAP similar genes for ADRBK2 Gene using alignment to 4 proteins:

Pseudogenes.org Pseudogenes for ADRBK2 Gene

genes like me logo Genes that share paralogs with ADRBK2: view

Variants for ADRBK2 Gene

Sequence variations from dbSNP and Humsavar for ADRBK2 Gene

SNP ID Clin Chr 22 pos Sequence Context AA Info Type MAF
rs133839 -- 25,727,521(+) AGAAA(C/T)GCAGG utr-variant-3-prime
rs713921 -- 25,583,267(+) TCATA(A/G)GTGGT intron-variant
rs715534 -- 25,700,210(+) ATATG(C/T)GCTAT intron-variant
rs718163 -- 25,685,906(-) AACAT(A/G)ATAAA intron-variant
rs721217 -- 25,636,527(+) CTGCT(A/G)TGAAA intron-variant

Structural Variations from Database of Genomic Variants (DGV) for ADRBK2 Gene

Variant ID Type Subtype PubMed ID
nsv7350 OTHER Inversion 18451855
dgv1392e1 CNV Complex 17122850
dgv1393e1 CNV Complex 17122850
dgv175e55 CNV Gain 17911159
dgv778e201 CNV Deletion 23290073
dgv577n27 CNV Gain 19166990
nsv517205 CNV Gain+Loss 19592680
nsv471189 CNV Gain 18288195
esv2751952 CNV Gain 17911159
dgv828e199 CNV Deletion 23128226
nsv436347 CNV Deletion 17901297
esv2724087 CNV Deletion 23290073
nsv469691 CNV Complex 16826518
nsv471598 CNV Gain+Loss 15918152
nsv914952 CNV Gain 21882294
nsv9892 CNV Gain 18304495
esv26366 CNV Gain 19812545
nsv9893 CNV Gain 18304495
esv2724088 CNV Deletion 23290073

Relevant External Links for ADRBK2 Gene

HapMap Linkage Disequilibrium report
ADRBK2
Human Gene Mutation Database (HGMD)
ADRBK2

Disorders for ADRBK2 Gene

(1) MalaCards Diseases for ADRBK2 Gene

Search for ADRBK2 Gene in MalaCards »

(5) Novoseek inferred disease relationships for ADRBK2 Gene

Disease -log(P) Hits PubMed IDs
bipolar disorder 50.9 13
retinoblastoma 23.9 1
mania 22.4 1
schizophrenia 6.31 5
shock 0 2

Relevant External Links for ADRBK2

Genetic Association Database (GAD)
ADRBK2
Human Genome Epidemiology (HuGE) Navigator
ADRBK2
genes like me logo Genes that share disorders with ADRBK2: view

No data available for UniProtKB/Swiss-Prot for ADRBK2 Gene

Publications for ADRBK2 Gene

  1. Molecular cloning, functional expression and mRNA analysis of human beta-adrenergic receptor kinase 2. (PMID: 8427589) Parruti G. … de Blasi A. (Biochem. Biophys. Res. Commun. 1993) 3 4 23
  2. Chromosome mapping of the human arrestin (SAG), beta-arrestin 2 (ARRB2), and beta-adrenergic receptor kinase 2 (ADRBK2) genes. (PMID: 7695743) Calabrese G. … De Blasi A. (Genomics 1994) 2 3 23
  3. Bipolar 1 disorder is not associated with the RGS4, PRODH, COMT and GRK3 genes. (PMID: 17106420) Prata D.P. … Collier D.A. (Psychiatr. Genet. 2006) 3 23 49
  4. Association analysis of GRK3 gene promoter variants in cocaine abuse. (PMID: 17621168) Guindalini C. … Breen G. (Psychiatr. Genet. 2007) 3 23 49
  5. Further evidence for association of GRK3 to bipolar disorder suggests a second disease mutation. (PMID: 18075471) Barrett T.B. … Kelsoe J.R. (Psychiatr. Genet. 2007) 3 23

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