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ADRBK2 Gene

protein-coding GIFtS: 65

GC22P024285

adrenergic, beta, receptor kinase 2
Symbol approved by the HUGO Gene Nomenclature Committee (HGNC) database

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc , and/or ⁷Ensembl, ⁸miRBase)
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Aliases
BARK2 ^¹, ², ³, ⁵
Beta-ARK-2 ^³
EC 2.7.11.15 ^³
GRK3 ^¹, ², ³, ⁵

Descriptions
G-protein-coupled receptor kinase 3 ^³
adrenergic, beta, receptor kinase 2 ^²
beta-adrenergic receptor kinase 2 ^²

External Ids
HGNC: 290¹
Entrez Gene: 157²
UniProtKB: P35626³
Ensembl: ENSG00000100077⁷

Search outside databases for aliases for ADRBK2 gene

Previous GC identifers: GC22P022657 GC22P024169

(According to Entrez Gene, Wikipedia's Gene Wiki,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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EntrezGene summary for ADRBK2:

The beta-adrenergic receptor kinase specifically phosphorylates the agonist-occupied form of the

beta-adrenergic and related G protein-coupled receptors. Overall, the beta adrenergic receptor

kinase 2 has 85% amino acid similarity with beta adrenergic receptor kinase 1, with the protein

kinase catalytic domain having 95% similarity. These data suggest the existence of a family of

receptor kinases which may serve broadly to regulate receptor function. [provided by RefSeq]

UniProtKB/Swiss-Prot: ARBK2_HUMAN, P35626

Function: Specifically phosphorylates the agonist-occupied form of the beta-adrenergic and closely

related receptors

Gene Wiki entry for ADRBK2 (Beta_adrenergic_receptor_kinase-2)

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 36),
and/or miRBase,
Genomic Views according to UCSC and Ensembl, Transcription factor binding sites according to SABiosciences)
About This Section

Genomic View:

UCSC Golden Path with GeneCards custom track

Transcription factor binding sites upstream to the ADRBK2 gene

Entrez Gene cytogenetic band: 22q11|22q12.1 Ensembl cytogenetic band: 22q11.23 HGNC cytogenetic band: 22q11

ADRBK2 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)

GeneLoc gene densities for chromosome 22 GeneLoc Exon Structure

GeneLoc location for GC22P024285: (about GC identifiers)

Start:	24,290,861 bp from pter
End:	24,455,259 bp from pter
Size:	164,399 bases
Orientation:	plus strand

RefSeq DNA sequence:

NC_000022.9 NT_011520.11

(According to ¹UniProtKB, and/or Ensembl, Phosphorylation sites according to ²Phosphosite, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Enzo Life Sciences, Abnova, OriGene and/or, Abcam,
Biochemical Assays by Invitrogen, Millipore, R&D Systems, Cell Signaling Technology, and/or Enzo Life Sciences, Ontologies according to Gene Ontology Consortium 01 Apr 2009 and Entrez Gene, Antibodies by Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Cell Signaling Technology, Abcam, Abnova, and/or Novus Biologicals)
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UniProtKB/Swiss-Prot: ARBK2_HUMAN, P35626 (See protein sequence)

Recommended Name: Beta-adrenergic receptor kinase 2

Size: 688 amino acids; 79710 Da

Secondary accessions: Q9UGW9

Post-translational modifications:

View phosphorylation sites using PhosphoSite²

REFSEQ proteins: NP_005151.2

ENSEMBL proteins:

ENSP00000317578

Human Recombinant Proteins

	Invitrogen human recombinant proteins for ADRBK2
	Millipore Purified and/or Recombinant ADRBK2 Protein
	Browse Human Recombinant Proteins at Sigma-Aldrich
	Browse R&D Systems for human recombinant proteins
	Browse recombinant and purified proteins available from Enzo Life Sciences
	Recombinant Proteins from Abcam (GRK3, GRK2 + 3)
	Human Recombinant Proteins from Abnova (ADRBK2)

Browse Origene for full length recombinant human proteins expressed in human HEK293 cells

2 Gene Ontology (GO) cellular component terms (links to tree view):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005634	nucleus	IDA	18029348
GO:0005886	plasma membrane	IDA	18029348

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Antibodies for ADRBK2:

	Browse Antibodies Central at Invitrogen
	Millipore Mono- and Polyclonal Antibodies for the study of ADRBK2
	Sigma-Aldrich Antibodies for ADRBK2
	Browse R&D Systems for Antibodies
	Antibodies from Abcam (GRK3, GRK2 + 3), each with their Abpromise^SM
	Monoclonal and Polyclonal Antibodies from Abnova (ADRBK2)
	Search Novus for antibodies for ADRBK2

Assays for ADRBK2:

	Invitrogen Assays for ADRBK2
	Browse Kits and Assays available from Millipore
	Browse R&D Systems for biochemical assays
	Browse biochemical assays available from Enzo Life Sciences

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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Graphical View of Domain Structure for InterPro Entry P35626

ProtoNet protein and cluster: P35626

4 Blocks protein families:

IPB000239 GPCR kinase signature

IPB000342 Regulator of G-protein signalling (RGS) protein signature

IPB000961 Protein kinase C-terminal domain

IPB001849 Pleckstrin-like

UniProtKB/Swiss-Prot: ARBK2_HUMAN, P35626

Similarity: Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. GPRK

subfamily

Similarity: Contains 1 AGC-kinase C-terminal domain

Similarity: Contains 1 PH domain

Similarity: Contains 1 protein kinase domain

Similarity: Contains 1 RGS domain

(According to MGI Jun 06 2009, UniProtKB, IUBMB,and/or Genatlas,
shRNA from OriGene, Sigma-Aldrich, RNAi from Sigma-Aldrich,
RNAi Products, Clones, and Q-PCR Products from Invitrogen, Millipore, OriGene, and/or Abnova, siRNAs from Applied Biosystems, SYBR primers from OriGene, Cell-based Assays from Millipore, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
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Inhib. RNA:		Invitrogen RNAi Products for gene knock-down (ADRBK2)
		Browse for Gene Knock-down Tools from Millipore
		Abnova Chimera RNAi Products for Gene knock-down (ADRBK2)

OriGene 29mer shRNA kit in GFP-retroviral vector: NM_005160

Applied Biosystems Silencer® siRNAs for ADRBK2

Sigma-Aldrich siRNA and siRNA Panels for ADRBK2

Sigma-Aldrich shRNA Panels and shRNA for ADRBK2

Explore Sigma-Aldrich super-pooled esiRNAs

Clones:		Invitrogen Clones for ADRBK2
		Millipore Clones for the Expression of ADRBK2

OriGene GFP tagged cDNA clone in CMV expression vector: NM_005160
Myc/DDK tagged cDNA clone in CMV expression vector: NM_005160
untagged cDNA clones in CMV expression vector (see all 3): NM_005160

Primers:

Browse Quantitative PCR Central at Invitrogen for Q-PCR LUX™ Primers

OriGene genome-wide validated SYBR primer pairs: NM_005160

UniProtKB/Swiss-Prot: ARBK2_HUMAN, P35626

Function: Specifically phosphorylates the agonist-occupied form of the beta-adrenergic and closely

related receptors

Catalytic activity: ATP + [beta-adrenergic receptor] = ADP + [beta-adrenergic receptor] phosphate

Enzyme Number (IUBMB): EC 2.7.11.15

Genatlas biochemistry entry for ADRBK2:

beta-adrenergic receptor kinase 2

1 MGI mutant phenotype (inferred from 1 allele) (MGI details for Adrbk2):

taste/olfaction

5/6 Gene Ontology (GO) molecular function terms (links to tree view) (see all 6 ):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0000166	nucleotide binding	IEA	--
GO:0004703	G-protein coupled receptor kinase activity	IEA	--
GO:0004871	signal transducer activity	IEA	--
GO:0005524	ATP binding	IEA	--
GO:0016740	transferase activity	IEA	--

About this table

(Pathways according to Invitrogen (maps by GeneGo), Millipore, Cell Signaling Technology, Sigma-Aldrich, KEGG and/or UniProtKB,
Sets of similar genes according to GeneDecks, Proteins Network according to SABiosciences, Interactions according to ¹UniProtKB, ²MINT, and/or ³STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
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1 Sigma-Aldrich "Your Favorite Gene" Pathway for ADRBK2 (Your Favorite Gene powered by Ingenuity)

Cardiac &beta

GeneDecks ADRBK2 for the pathways selected above

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Gene Network Central^TM Interacting Genes and Proteins Network for ADRBK2

5/15 Interacting proteins for ADRBK2 (ENSP00000317578³) via UniProtKB, MINT, and/or STRING (see all 15 )

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
RHO	ENSP00000296271³	STRING (score=.959)
SUCLG2	ENSP00000307432³	STRING (score=.955)
SAG	ENSP00000252857³	STRING (score=.951)
ADRB2	ENSP00000305372³	STRING (score=.941)
GNAQ	ENSP00000286548³	STRING (score=.925)

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2 Gene Ontology (GO) biological process terms (links to tree view):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0006468	protein amino acid phosphorylation	IEA	--
GO:0007165	signal transduction	TAS	8427589

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(Chemical Compounds according to UniProtKB, Enzo Life Sciences, Sigma-Aldrich, Tocris Bioscience, and/or Novoseek and Drugs according to Enzo Life Sciences and/or PharmGKB)
About This Section

Browse drugs & compounds from Enzo Life Sciences

Browse Small Molecules at Sigma-Aldrich

Browse Tocris compounds for ADRBK2
6 Novoseek chemical compound relationships for ADRBK2 gene

Compound	Score	Articles	PubMed IDs for Articles with Shared Sentences (# sentences)
damgo	49.73	5	12750434 (3), 11299306 (1), 10092593 (1)
pip2	44.09	3	8798768 (2)
ionomycin	22.93	1	17179467 (1)
oligonucleotide	0.00	1	11247813 (1)
lipid	0.00	1	7673171 (1)
calcium	0.00	2	17179467 (1), 18388243 (1)

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1 PharmGKB drug compound relationship for ADRBK2 gene

Drug compound	PharmGKB Relations	PubMed IDs for articles supporting these relationships
Beta adrenergic antagonists	FA	11900882 14499340

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(GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 219 Homo sapiens; Jun 2 2009) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView,
non coding RNAs according to RNAdb,
ESTs according to GeneTide,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from Invitrogen, Millipore, and/or Abnova,
siRNAs from Applied Biosystems, Sigma-Aldrich,
shRNA from Sigma-Aldrich, OriGene,
Tagged/untagged cDNA clones from OriGene,
Expression Assays from Applied Biosystems)
About This Section

Inhib. RNA:		Invitrogen RNAi Products for gene knock-down (ADRBK2)
		Browse for Gene Knock-down Tools from Millipore
		Abnova Chimera RNAi Products for Gene knock-down (ADRBK2)

OriGene 29mer shRNA kit in GFP-retroviral vector: NM_005160

Sigma-Aldrich siRNA and siRNA Panels for ADRBK2

Sigma-Aldrich shRNA Panels and shRNA for ADRBK2

Explore Sigma-Aldrich super-pooled esiRNAs

Applied Biosystems Silencer® siRNAs:

NM_005160

REFSEQ mRNAs for ADRBK2 gene:

NM_005160.3

Applied Biosystems TaqMan ® Gene Expression Assays:

NM_005160

              OriGene GFP tagged cDNA clone in CMV expression vector: NM_005160
                                 Myc/DDK tagged cDNA clone in CMV expression vector: NM_005160
                                 untagged cDNA clones in CMV expression vector (see all 3): NM_005160

Additional cDNA sequence:

AK055687.1 AK058103.1 AK123767.1 AK124922.1 AK292234.1 AK310398.1 BC021221.2 BC029563.1

BC036797.1 BC063545.1 CR617875.1 X69117.1

12 DOTS entries:

DT.314219 DT.120646222 DT.413854 DT.91871442 DT.120646260 DT.95269662 DT.100732870 DT.99992562

DT.100639923 DT.91673436 DT.91891950 DT.99945421

24/198 AceView cDNA sequences (see all 198 ):

CK825274 AA287659 BM310555 AV720235 AA257973 BC063545 AA830671 BI518807

AA741445 CA844322 F07794 AK055687 BX390226 N38770 AA322997 BX104431

CA418731 BF056793 AA832344 AW630342 CA849005 BC036797 BG058574 AW236822

highest scoring ESTs for ADRBK2:

AA047782 AA057617 AA250850 AA278408 AA279133 AA287659 AA287692 AA526240 AA579796 AA648393

Unigene Cluster for ADRBK2:

Adrenergic, beta, receptor kinase 2

Hs.657494 [show with all ESTs]

Unigene Representative Sequence: NM_005160

GeneLoc Exon Structure

4 Alternative Splicing Database (ASD) splice patterns (SP) for ADRBK2

ExUns:	1	^	2	^	3	^	4a	·	4b	·	4c	^	5	^	6	^	7	^	8	^	9a	·	9b	·	9c	^	10	^	11	^	12	^	13	^	14a	·	14b	^	15	^	16	^	17	^	18	^	19	^	20	^	21	^
SP1:							-		-						-														-
SP2:
SP3:															-
SP4:

ExUns:	22	^	23	^	24
SP1:
SP2:
SP3:
SP4:

About this scheme

ECgene alternative splicing isoforms for ADRBK2

1 Ensembl transcript including schematic representation:

ENST00000324198

(Experimental results according to ¹GeneNote and GNF BioGPS,
probe sets-to-genes annotations according to ²GeneAnnot , ³GeneTide , Sets of similar genes according to GeneDecks, Electronic Northern calculations according to data from UniGene (Build 219 Homo sapiens), SAGE tags according to CGAP, plus additional links to SOURCE, and/or GNF BioGPS, and/or EXPOLDB, and/or UniProtKB,
Expression Assays from Applied Biosystems )
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ADRBK2 expression in normal and diseased human tissues

Applied Biosystems TaqMan ® Gene Expression Assays for ADRBK2

¹ / ² / ³

11 probe-sets matching ADRBK2 gene

Affymetrix probe-set	Array	# genes	Sensitivity	Specificity	Correlation	Length	Gb_Accession	Consensus	Uniqueness	Score	Rank
Affymetrix probe-set	Array	GeneAnnot data			GeneNote data		GeneTide data
91589_at²^{, 3}	U95-E	1	1.00	1.00	0.93	1.56	AI681911	0.80	1.00	0.91	1
51940_at²^{, 3}	U95-C	1	1.00	1.00	0.81	0.82	AL046134	0.40	1.00	0.76	1
31795_at²^{, 3}	U95-A	1	1.00	1.00	0.95	0.79	AL022329	0.20	1.00	0.72	1
52075_at²^{, 3}	U95-B	1	1.00	1.00	0.91	1.32	AI651212	0.80	1.00	0.91	1
724_at²^{, 3}	U95-A	1	1.00	1.00	0.69	0.55	HG1604-HT1604	0.20	1.00	0.72	1
228771_at²^{, 3}	U133-B	1	1.00	1.00	--	--	AI651212	0.80	1.00	0.91	1
204184_s_at²^{, 3}	U133-A	1	1.00	1.00	--	--	NM_005160	0.60	1.00	0.82	1
204183_s_at²^{, 3}	U133-A	1	1.00	1.00	--	--	AI478542	0.80	1.00	0.91	1
228771_at²	U133Plus2	1	1.00	1.00	--	--	--	--	--	--	--
204184_s_at²	U133Plus2	1	1.00	1.00	--	--	--	--	--	--	--
204183_s_at²	U133Plus2	1	1.00	1.00	--	--	--	--	--	--	--

GeneDecks ADRBK2 for binary patterns associated with the probe-sets selected above

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Data from

(Publications) and GNF BioGPS
About these images
About these images

CGAP SAGE TAG: ACTGAAACTT

SOURCE GeneReport for Unigene cluster: Hs.657494
Expression variation in blood from EXPOLDB for ADRBK2

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD and/or ⁵MGI Jun 06 2009, with possible further links to Flybase and/or WormBase, Gene Trees according to Ensembl)
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Orthologs for ADRBK2 gene from 5/10 species (see all 10 )

Organism	Gene	Locus	Description	Human Similarity	NCBI accessions
dog (Canis familiaris)	ADRBK2¹	--	adrenergic, beta, receptor kinase 2	89.06(n) 94.58(a)	486327 XM_543453.2 XP_543453.2
cow (Bos taurus)	ADRBK2¹	--	adrenergic, beta, receptor kinase 2	89.44(n) 95.49(a)	282136 NM_174500.2 NP_776925.1
rat (Rattus norvegicus)	Adrbk2¹	--	adrenergic, beta, receptor kinase 2	83.77(n) 91.13(a)	25372 NM_012897.1 NP_037029.1
mouse (Mus musculus)	Adrbk2^{1, 5}	5 (60.00 cM)⁵	adrenergic receptor kinase, beta 2^{1, 5}	83.14(n)¹ 91.42(a)¹	320129¹ NM_177078.3¹ NP_796052.2¹ AA396516⁵ AI851927⁵ (see all 16)
chicken (Gallus gallus)	ADRBK2¹	--	adrenergic, beta, receptor kinase 2	82.9(n) 93.83(a)	416904 XM_415195.2 XP_415195.2

About this table Species with no ortholog for ADRBK2

ENSEMBL Gene Tree for ADRBK2

(Paralogs according to ¹HomoloGene
and ²Ensembl, Pseudogenes according to ³Pseudogene.org)
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Paralogs for ADRBK2 gene

GRK7² ADRBK1²

(According to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, and UniProtKB, Linkage Disequilibrium by HapMap, Genotyping Reagents from Applied Biosystems)
About This Section

10/701 NCBI SNPs in ADRBK2 are shown (see all 701 )
(Click for Applied Biosystems TaqMan ® Genotyping Assay) (see all 196)

AB	SNP ID	Valid	Chr 22 pos	Sequence	Recs	AA Chg	Type	More	Recs	Pop	Total sample	More
AB	Genomic Data				Transcription Data				Allele Frequencies
				--	--	--		--	--			--
	rs768086^1,2	A,C,F,H,O	24450336(+)	`TATCTC/TGTACC`	1	--	ut3¹		11	MN NA EU EA WA	1098
--	rs5761122^1,2	A,C,F,H	24289309(+)	`CCTTCG/AACTGC`	1	--	ng5¹		4	EU EA WA	418
	rs6519623^1,2	A,C,F,H	24448976(+)	`AGCCGC/TACCCA`	1	--	ut3¹		7	NA EU EA WA	554
	rs6519622^1,2	A,C,F,H	24448524(+)	`TCCAGG/ACTCCC`	1	--	ut3¹ ese³		4	EU EA WA	418
	rs2205971^1,2	A,C,F,H	24288952(+)	`TATACT/CGTGCT`	1	--	ng5¹		4	EU EA WA	418
	rs2272859^1,2	C,F,H	24429541(+)	`TCACCG/ATGGTA`	1	M/V	mis¹ ese³		8	EU EA WA	832
	rs3827376^1,2	C,F,H	24454125(+)	`ATTGAA/CATAAT`	1	--	ut3¹		5	EU EA WA	598
	rs16980612^1,2	C,F,H	24449104(+)	`CATCAT/CTGGAA`	1	--	ut3¹ ese³		7	NA EU EA WA	562
	rs3747127^1,2	C,F,H	24448500(+)	`TGATCT/CATTCG`	1	--	ut3¹ ese³		8	EA NA EU WA	2060
	rs133839^1,2	C,F,H	24453488(+)	`AGAAAT/CGCAGG`	1	--	ut3¹		5	MN EU EA WA	600

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HapMap Linkage Disequilibrium images for ADRBK2 (up to first 250kb)

(in which this Gene is Involved, According to OMIM, UniProtKB, Novoseek, PharmGKB, Genatlas, GeneTests, Blood group antigen gene mutations by BGMUT, HGMD, GAD, HuGE Navigator, BCGD, and/or TGDB.)
About This Section

OMIM: 109636

5 Novoseek disease relationships for ADRBK2 gene

Disease	Score	Articles	PubMed IDs for Articles with Shared Sentences (# sentences)
bipolar disorder	50.39	14	17106420 (2), 18075471 (2), 18359007 (2), 16359584 (2) (see all 6)
retinoblastoma	25.85	2	11166332 (1)
mania	24.92	1	12808434 (1)
schizophrenia	9.20	9	15006433 (4), 17106420 (1)
shock	0.00	2	17179467 (2)

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2 PharmGKB disease relationships for ADRBK2 gene

Disease	PharmGKB Relations	PubMed IDs for articles supporting these relationships
Heart Failure, Congestive	FA	14499340
Hypertension	FA	14499340

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Human Gene Mutation Database: ADRBK2
Human Genome Epidemiology Navigator: ADRBK2 (5 documents)

(Possibly Related Articles in Doctor's Guide)
About This Section

(in PubMed. Associations of this gene to articles via ¹Novoseek, ²HGNC, ³Entrez Gene, ⁴UniProtKB/Swiss-Prot, ⁵UniProtKB/TrEMBL, ⁶GAD, and/or ⁷PharmGKB)
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10/97 PubMed articles for ADRBK2 gene (see all 97 ):

Chromosome mapping of the human arrestin (SAG), beta-arrestin 2 (ARRB2), and beta-adrenergic receptor kinase 2 (ADRBK2) genes. (PubMed id 7695743)^{1, 2, 3} Calabrese G....De Blasi A. (1994)
Molecular cloning, functional expression and mRNA analysis of human beta-adrenergic receptor kinase 2. (PubMed id 8427589)^{1, 3, 4} Parruti G.... de Blasi A. (1993)
The DNA sequence of human chromosome 22. (PubMed id 10591208)^{3, 4} Dunham I....O'Brien K.P. (1999)
Evidence that a single nucleotide polymorphism in the promoter of the G protein receptor kinase 3 gene is associated with bipolar disorder. (PubMed id 12808434)^{1, 3} Barrett T.B....Kelsoe J.R. (2003)
Leukocyte analysis from WHIM syndrome patients reveals a pivotal role for GRK3 in CXCR4 signaling. (PubMed id 18274673)^{1, 3} Balabanian K....Bachelerie F. (2008)
Further evidence for association of GRK3 to bipolar disorder suggests a second disease mutation. (PubMed id 18075471)^{1, 3} Barrett T.B....Kelsoe J.R. (2007)
Association analysis of GRK3 gene promoter variants in cocaine abuse. (PubMed id 17621168)^{1, 3} Guindalini C....Breen G. (2007)
Promoter variant in the GRK3 gene associated with bipolar disorder alters gene expression. (PubMed id 18359007)^{1, 3} Zhou X....Kelsoe J.R. (2008)
Bipolar 1 disorder is not associated with the RGS4, PRODH, COMT and GRK3 genes. (PubMed id 17106420)^{1, 3} Prata D.P....Collier D.A. (2006)
Threonine 180 is required for G-protein-coupled receptor kinase 3- and beta-arrestin 2-mediated desensitization of the mu-opioid receptor in Xenopus oocytes. (PubMed id 11060299)^{1, 3} Celver J.P....Chavkin C. (2001)

(in PubMed, OMIM, and NCBI Bookshelf)
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		AND	OR
Aliases
Free Text

Query String		PubMed OMIM NCBI Bookshelf
	(Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, and/or H-InvDB)
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Entrez Gene: 157	HGNC: 290	AceView: ADRBK2	Ensembl:ENSG00000100077	euGenes: HUgn157
ECgene: ADRBK2	H-InvDB: ADRBK2

(According to HUGE)
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(According to ATLAS, HORDE, IMGT, MTDB, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
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Licensable Technologies for ADRBK2
(Available from WIS Yeda, Salk, Tufts)

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(Reagents available from Applied Biosystems, Antibodies and assays by Cell Signaling Technology, Abcam, Novus Biologicals,
Sigma-Aldrich, R&D Systems, Millipore, Abnova, and/or Invitrogen, Clones available from OriGene,and/or Invitrogen, Drugs and/or compounds by Sigma-Aldrich,
Enzo Life Sciences, and/or Tocris Bioscience)
About This Section

Products for ADRBK2:

TaqMan ® Gene Expression Assays

TaqMan ® Genotyping Assays

Free SNP selection tool

Invitrogen iPath Pathways	Invitrogen BLOCK-iT™ RNAi
Invitrogen Antibodies	Invitrogen Assays
Invitrogen Clones	Invitrogen Q-PCR Products
Invitrogen Human Recombinant Kinases	Invitrogen Custom Antibody and Peptide Service
Invitrogen Proteins / Assays / Screening Services	Search Invitrogen catalog for ADRBK2-related products

	Millipore Custom Antibody & Bulk Services
	Millipore Preclinical / Clinical Development Services
	Millipore Immunoassay Services
	Millipore Target Screening & Profiling Services

	Predesigned and custom siRNAs for ADRBK2		Antibodies for ADRBK2
	Explore super-pooled esiRNAs		Browse proteins at Sigma-Aldrich
	Lentivirus-delivered shRNAs for ADRBK2		Browse small molecules at Sigma-Aldrich
	"Your Favorite Gene" Pathways		feedback

	Antibodies		Primer Pairs
	Cell Culture Products		ELISAs
	Flow Cytometry Kits		Protease Activity Assays & Reagents
	Cell Selection/Detection Kits & Reagents		ELISA/Assay Development Kits & Reagents
	Multiplex/Array Assay Kits & Reagents		ELISpot Kits & Development Modules
	Recombinant & Natural Proteins

	Recombinant Proteins (ADRBK2)
	Antibodies (ADRBK2)
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	Custom Service for Rabbit Pab from Full-length Protein

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	Recombinant Proteins (GRK3, GRK2 + 3)
	Antibodies (GRK3, GRK2 + 3)

Search OriGene for ADRBK2

Search Tocris compounds for ADRBK2

Search www.enzolifesicences.com for proteins, assays, substrates, inhibitors & antibodies

Search Novus for antibodies for ADRBK2

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Gene Index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

Developed at the Crown Human Genome Center & Weizmann Institute of Science

The GeneCards Human Gene Database: Copyright © 1996-2009, Weizmann Institute of Science. All Rights Reserved.
ADRBK2 Gene at Home site.
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ADRBK2 Gene

protein-coding GIFtS: 65

Aliases &
Descriptions
for ADRBK2

Summaries
for ADRBK2

Genomic Location
for ADRBK2

Proteins
for ADRBK2

Protein Domains/
Families
for ADRBK2

Gene Function
for ADRBK2

Pathways & Interactions
for ADRBK2

Drugs & Compounds
for ADRBK2

Transcripts
for ADRBK2

Expression
for ADRBK2

Orthologs
for ADRBK2

Paralogs
for ADRBK2

SNPs/Variants
for ADRBK2

Disorders & Mutations
for ADRBK2

Medical News
for ADRBK2

Publications
for ADRBK2

Search for ADRBK2

Genome Databases showing ADRBK2

Other Databases showing ADRBK2

Specialized Databases showing ADRBK2

Licensable Technologies
for ADRBK2

Services
for ADRBK2

Gene Index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

ADRBK2 Gene

protein-coding GIFtS: 65

Aliases & Descriptionsfor ADRBK2

Summariesfor ADRBK2

Genomic Locationfor ADRBK2

Proteinsfor ADRBK2

Protein Domains/Familiesfor ADRBK2

Gene Functionfor ADRBK2

Pathways & Interactionsfor ADRBK2

Drugs & Compoundsfor ADRBK2

Transcriptsfor ADRBK2

Expression for ADRBK2

Orthologsfor ADRBK2

Paralogsfor ADRBK2

SNPs/Variantsfor ADRBK2

Disorders & Mutationsfor ADRBK2

Medical Newsfor ADRBK2

Publicationsfor ADRBK2

Search for ADRBK2

Genome Databases showing ADRBK2

Other Databases showing ADRBK2

Specialized Databases showing ADRBK2

Licensable Technologiesfor ADRBK2

Servicesfor ADRBK2

Gene Index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

Aliases &
Descriptions
for ADRBK2

Summaries
for ADRBK2

Genomic Location
for ADRBK2

Proteins
for ADRBK2

Protein Domains/
Families
for ADRBK2

Gene Function
for ADRBK2

Pathways & Interactions
for ADRBK2

Drugs & Compounds
for ADRBK2

Transcripts
for ADRBK2

Expression
for ADRBK2

Orthologs
for ADRBK2

Paralogs
for ADRBK2

SNPs/Variants
for ADRBK2

Disorders & Mutations
for ADRBK2

Medical News
for ADRBK2

Publications
for ADRBK2

Licensable Technologies
for ADRBK2

Services
for ADRBK2