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ADRBK2 Gene

protein-coding   GIFtS: 70
GCID: GC22P025960

Adrenergic, Beta, Receptor Kinase 2

  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Adrenergic, Beta, Receptor Kinase 21 2     beta-ARK-22
BARK22 3 5     Beta-Adrenergic Receptor Kinase 22
GRK32 3 5     Beta-ARK-23
G-Protein-Coupled Receptor Kinase 32 3     EC 2.7.118
EC 2.7.11.153 8     

External Ids:    HGNC: 2901   Entrez Gene: 1572   Ensembl: ENSG000001000777   OMIM: 1096365   UniProtKB: P356263   

Export aliases for ADRBK2 gene to outside databases

Previous GC identifers: GC22P022657 GC22P024169 GC22P024285 GC22P008764


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for ADRBK2 Gene:
The beta-adrenergic receptor kinase specifically phosphorylates the agonist-occupied form of the beta-adrenergic
and related G protein-coupled receptors. Overall, the beta adrenergic receptor kinase 2 has 85% amino acid
similarity with beta adrenergic receptor kinase 1, with the protein kinase catalytic domain having 95%
similarity. These data suggest the existence of a family of receptor kinases which may serve broadly to regulate
receptor function. (provided by RefSeq, Jul 2008)

GeneCards Summary for ADRBK2 Gene:
ADRBK2 (adrenergic, beta, receptor kinase 2) is a protein-coding gene. Diseases associated with ADRBK2 include whim syndrome, and cocaine abuse. GO annotations related to this gene include phospholipid binding and G-protein coupled receptor kinase activity. An important paralog of this gene is AKT1.

UniProtKB/Swiss-Prot: ARBK2_HUMAN, P35626
Function: Specifically phosphorylates the agonist-occupied form of the beta-adrenergic and closely related
receptors

Gene Wiki entry for ADRBK2 (Beta adrenergic receptor kinase-2) Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence:
NC_000022.11  NT_011520.13  NC_018933.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the ADRBK2 gene promoter:
         AP-2alpha isoform 3   AP-2alpha isoform 2   AP-2alpha isoform 4   AP-2alpha   AP-2alphaA   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidADRBK2 promoter sequence
   Search Chromatin IP Primers for ADRBK2

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat ADRBK2


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 22q12.1   Ensembl cytogenetic band:  22q12.1   HGNC cytogenetic band: 22q11

ADRBK2 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
ADRBK2 gene location

GeneLoc information about chromosome 22         GeneLoc Exon Structure

GeneLoc location for GC22P025960:  view genomic region     (about GC identifiers)

Start:
25,960,816 bp from pter      End:
26,125,261 bp from pter
Size:
164,446 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: ARBK2_HUMAN, P35626 (See protein sequence)
Recommended Name: Beta-adrenergic receptor kinase 2  
Size: 688 amino acids; 79710 Da
Secondary accessions: Q9UGW9

Explore the universe of human proteins at neXtProt for ADRBK2: NX_P35626

Explore proteomics data for ADRBK2 at MOPED

Post-translational modifications: 

  • Ubiquitinated1
  • Ubiquitination2 at Lys230, Lys507
  • Modification sites at PhosphoSitePlus
  • Selected DME Specific Peptides for ADRBK2 (P35626) (see all 23)
     VVYRDLK  CSHPFSK  YMAPEVL  LRGDIFQ 


    See ADRBK2 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_005151.2  
    ENSEMBL proteins: 
     ENSP00000317578   ENSP00000393688  

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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    PLEKH: Pleckstrin homology (PH) domain containing

    IUPHAR Guide to PHARMACOLOGY protein family classification: adrenergic, beta, receptor kinase 2
    G protein coupled receptor kinases
    BARK subfamily

    Selected InterPro protein domains (see all 11):
     IPR017441 Protein_kinase_ATP_BS
     IPR000239 GPCR_kinase
     IPR002290 Ser/Thr_dual-sp_kinase_dom
     IPR011009 Kinase-like_dom
     IPR001849 Pleckstrin_homology

    Graphical View of Domain Structure for InterPro Entry P35626

    ProtoNet protein and cluster: P35626

    4 Blocks protein domains:
    IPB000239 GPCR kinase signature
    IPB000342 Regulator of G-protein signalling (RGS) protein signature
    IPB000961 Protein kinase C-terminal domain
    IPB001849 Pleckstrin-like


    UniProtKB/Swiss-Prot: ARBK2_HUMAN, P35626
    Similarity: Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. GPRK subfamily
    Similarity: Contains 1 AGC-kinase C-terminal domain
    Similarity: Contains 1 PH domain
    Similarity: Contains 1 protein kinase domain
    Similarity: Contains 1 RGS domain


    ADRBK2 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: ARBK2_HUMAN, P35626
    Function: Specifically phosphorylates the agonist-occupied form of the beta-adrenergic and closely related
    receptors
    Catalytic activity: ATP + [beta-adrenergic receptor] = ADP + [beta-adrenergic receptor] phosphate

         Genatlas biochemistry entry for ADRBK2:
    beta-adrenergic receptor kinase 2

         Enzyme Numbers (IUBMB): EC 2.7.11.151 2 EC 2.7.112

         Gene Ontology (GO): Selected molecular function terms (see all 7):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0004672protein kinase activity TAS8427589
    GO:0004674protein serine/threonine kinase activity ----
    GO:0004703G-protein coupled receptor kinase activity IEA--
    GO:0004713protein tyrosine kinase activity ----
    GO:0005524ATP binding IEA--
         
    ADRBK2 for ontologies           About GeneDecksing


    Phenotypes:
         5 GenomeRNAi human phenotypes for ADRBK2:
     Decreased focal adhesion (FA)   Decreased viability  Increased G1 DNA content  Increased cell death HMECs cel 
     Lamellipodia and high actin ra 

         1 MGI mutant phenotype (inferred from 1 allele(MGI details for Adrbk2):
     taste/olfaction 

    ADRBK2 for phenotypes           About GeneDecksing

    Animal Models:
         MGI mouse knock-out Adrbk2tm1Rjl for ADRBK2

       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for ADRBK2
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    miRTarBase miRNAs that target ADRBK2:
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    Block miRNA regulation of human, mouse, rat ADRBK2 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate ADRBK2 (see all 93):
    hsa-miR-3607-3p hsa-miR-15a hsa-miR-199a-3p hsa-miR-138-2* hsa-miR-519a hsa-miR-1244 hsa-miR-298 hsa-miR-376c
    Browse SwitchGear 3'UTR luciferase reporter plasmids
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    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    cytosol3
    nucleus2
    peroxisome1
    plasma membrane1

    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for ADRBK2 About   (see all 10)  
    See pathways by source

    SuperPathContained pathways About
    1ADP signalling through P2Y purinoceptor 12
    Development Angiotensin signaling via beta Arrestin0.39
    Beta-agonist/Beta-blocker Pathway, Pharmacodynamics0.34
    2Chemokine Signaling
    Chemokine signaling pathway0.33
    Chemokine Signaling0.33
    3Circadian entrainment
    Morphine addiction0.53
    Glutamatergic synapse0.39
    4Olfactory Signaling Pathway
    Olfactory transduction0.82
    5Thromboxane A2 receptor signaling
    Thromboxane A2 receptor signaling

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    2 Downloadable PowerPoint Slides of GeneGlobe Pathway Central Maps for ADRBK2
        Chemokine Signaling
    Colorectal Cancer Metastasis

    1 GeneGo (Thomson Reuters) Pathway for ADRBK2
        Development Angiotensin signaling via beta-Arrestin

    3 BioSystems Pathways for ADRBK2
        IL-4 signaling Pathway
    Corticotropin-releasing hormone
    Thromboxane A2 receptor signaling


    2 PharmGKB Pathways for ADRBK2
        Beta-agonist/Beta-blocker Pathway, Pharmacodynamics
    Diuretics Pathway, Pharmacodynamics

    5 Kegg Pathways  (Kegg details for ADRBK2):
        Chemokine signaling pathway
    Endocytosis
    Glutamatergic synapse
    Olfactory transduction
    Morphine addiction


    ADRBK2 for pathways           About GeneDecksing

        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for ADRBK2
    Interactions:

        GeneGlobe Interaction Network for ADRBK2

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for ADRBK2 (P356263 ENSP000003175784) via UniProtKB, MINT, STRING, and/or I2D (see all 382)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    BDKRB2P304113, ENSP000003077134I2D: score=2 STRING: ENSP00000307713
    AGTR1P305563, ENSP000002734304I2D: score=1 STRING: ENSP00000273430
    OPRM1P353723, ENSP000003946244I2D: score=1 STRING: ENSP00000394624
    UBCP0CG483, ENSP000003448184I2D: score=1 STRING: ENSP00000344818
    CCR4P516793, ENSP000003326594I2D: score=2 STRING: ENSP00000332659
    About this table

    Gene Ontology (GO): 4 biological process terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006468protein phosphorylation ----
    GO:0007165signal transduction IEA--
    GO:0031623receptor internalization IDA--
    GO:0038032termination of G-protein coupled receptor signaling pathway IEA--

    ADRBK2 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for ADRBK2 (ARBK2)

    3 HMDB Compounds for ADRBK2    About this table
    CompoundSynonyms CAS #PubMed Ids
    ADPadenosindiphosphorsaeure (see all 8)58-64-0--
    Adenosine triphosphate5'-(tetrahydrogen triphosphate) Adenosine (see all 24)56-65-5--
    ZincZinc (see all 2)7440-66-6--

    1 DrugBank Compound for ADRBK2    About this table
    CompoundSynonyms CAS #TypeActionsPubMed Ids
    Adenosine triphosphate5'-ATP (see all 8)56-65-5target--17139284 17016423

    Selected Novoseek inferred chemical compound relationships for ADRBK2 gene (see all 13)    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    damgo 48.2 5 12750434 (3), 11299306 (1), 10092593 (1)
    geldanamycin 43.9 6 17179467 (3)
    pip2 42.6 3 8798768 (2)
    epinephrine 38.5 17 17255468 (4), 15192083 (3), 15456839 (2), 16533872 (1) (see all 5)
    ionomycin 21.3 1 17179467 (1)
    methamphetamine 21.2 2 17621168 (1)
    alanine 18.7 1 9849959 (1)
    propranolol 7.55 2 12642394 (1), 17255468 (1)
    isoproterenol 5.38 1 12020767 (1)
    oligonucleotide 0 1 11247813 (1)



    ADRBK2 for compounds           About GeneDecksing



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
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    REFSEQ mRNAs for ADRBK2 gene: 
    NM_005160.3  

    Unigene Cluster for ADRBK2:

    Adrenergic, beta, receptor kinase 2
    Hs.657494  [show with all ESTs]
    Unigene Representative Sequence: NM_005160
    2 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000324198(uc010gux.3 uc003abw.2 uc003abx.4 uc003aby.4)
    ENST00000455558
    miRNA
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    Selected qRT-PCR Assays for microRNAs that regulate ADRBK2 (see all 93):
    hsa-miR-3607-3p hsa-miR-15a hsa-miR-199a-3p hsa-miR-138-2* hsa-miR-519a hsa-miR-1244 hsa-miR-298 hsa-miR-376c
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    Additional mRNA sequence: 

    AK055687.1 AK058103.1 AK123767.1 AK124922.1 AK292234.1 AK310398.1 BC021221.2 BC029563.1 
    BC036797.1 BC063545.1 X69117.1 

    12 DOTS entries:

    DT.314219  DT.120646222  DT.413854  DT.120646260  DT.91871442  DT.95269662  DT.100732870  DT.99992562 
    DT.100639923  DT.91673436  DT.91891950  DT.99945421 

    Selected AceView cDNA sequences (see all 198):

    AA287659 BF056176 N38770 BC063545 BI518807 CA844322 AK055687 CK825274 
    AA278408 BM310555 AW631488 BX645400 AW630342 AA742193 F07794 BX091490 
    CA849005 AV720497 AV720235 CA418731 BC036797 AA257973 BF056793 H55606 

    GeneLoc Exon Structure

    4 Alternative Splicing Database (ASD) splice patterns (SP) for ADRBK2    About this scheme

    ExUns: 1 ^ 2 ^ 3 ^ 4a · 4b · 4c ^ 5 ^ 6 ^ 7 ^ 8 ^ 9a · 9b · 9c ^ 10 ^ 11 ^ 12 ^ 13 ^ 14a · 14b ^ 15 ^ 16 ^ 17 ^ 18 ^ 19 ^ 20 ^ 21 ^
    SP1:                    -     -                 -                                         -                                                                     
    SP2:                                                                                                                                                            
    SP3:                                            -                                                                                                               
    SP4:                                                                                                                                                            

    ExUns: 22 ^ 23 ^ 24
    SP1:                  
    SP2:                  
    SP3:                  
    SP4:                  


    ECgene alternative splicing isoforms for ADRBK2

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

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    ADRBK2 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: ACTGAAACTT
    ADRBK2 Expression
    About this image


    ADRBK2 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 4) fully expand
     
     Adipose (Muscoskeletal System)
             Interscapular Brown Adipose Depot
     
     Liver (Hepatobiliary System)
             Hematopoietic Stem Cells Liver Bud
     
     Blood (Cardiovascular System)
             Hematopoietic Stem Cells Liver Bud
     
     Neural Tube (Nervous System)
             Spinal Ventral Columns
    ADRBK2 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    ADRBK2 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.657494
        Custom PCR Arrays for ADRBK2
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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ADRBK2

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of animals.

    Orthologs for ADRBK2 gene from Selected species (see all 15)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Adrbk21 , 5 adrenergic receptor kinase, beta 21, 5 83.14(n)1
    91.42(a)1
      5 (55.29 cM)5
    3201291  NM_177078.41  NP_796052.21 
     1129104785 
    chicken
    (Gallus gallus)
    Aves ADRBK21 adrenergic, beta, receptor kinase 2 82.74(n)
    93.39(a)
      416904  XM_415195.4  XP_415195.4 
    lizard
    (Anolis carolinensis)
    Reptilia --
    --
    83(a)
    many ↔ many
    AAWZ02041337(1634-5304)
    tropical clawed frog
    (Xenopus tropicalis)
    Amphibia adrbk21 adrenergic, beta, receptor kinase 2 82.7(n)
    92.73(a)
      100379889  XM_002932071.2  XP_002932117.2 
    zebrafish
    (Danio rerio)
    Actinopterygii adrbk21 adrenergic, beta, receptor kinase 2 76.26(n)
    90.55(a)
      569403  NM_001134725.1  NP_001128197.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta Gprk11 , 3 protein amino acid phosphorylation
    protein serine/threonine more3
    G protein-coupled receptor kinase 11
    66(a)3
    63.19(n)1
    68.38(a)1
      33550131  NM_001169580.21  NP_001163051.11 
    worm
    (Caenorhabditis elegans)
    Secernentea W02B3.23
    grk-21
    G-protein coupled receptor3
    grk-21
    69(a)3
    63.67(n)1
    68.04(a)1
      III(676123-680041)3
    1752231  NM_064834.41  NP_497235.21 


    ENSEMBL Gene Tree for ADRBK2 (if available)
    TreeFam Gene Tree for ADRBK2 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for ADRBK2 gene
    AKT12  GRK72  RPS6KB12  GRK12  SGK32  GRK42  GRK62  C8orf44-SGK32  
    SGK22  AKT32  SGK12  RPS6KB22  GRK52  ADRBK12  AKT22  
    11 SIMAP similar genes for ADRBK2 using alignment to 4 protein entries:     ARBK2_HUMAN (see all proteins):
    ADRBK1    AKT2    PRKAA1    GRK5    GRK4    SGK2
    GRK7    PRKACG    SGK1    GRK1    GRK6

    ADRBK2 for paralogs           About GeneDecksing


    2 Pseudogenes.org Pseudogenes for ADRBK2
    PGOHUM00000246547 PGOHUM00000246550


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for ADRBK2 (see all 3228)    About this table    
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 22 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    VAR_0403824
    A lung bronchoalveolar carcinoma sample4--see VAR_0403822 R K mis40--------
    rs1875119841,2
    Cuntested126062914(+) GGAAAA/GCTGAT 1 -- int10--------
    rs738795031,2
    C,F--25962823(+) TGTAGT/GATTTC 1 -- int17Minor allele frequency- G:0.34WA NA CSA 246
    rs760801731,2
    C,F--25962824(+) GTAGTA/GTTTCT 1 -- int12Minor allele frequency- G:0.06WA NA 238
    rs614122041,2
    C,F--25962830(+) TTTCTA/GTATAC 1 -- int11Minor allele frequency- G:0.04EA 120
    rs1997124781,2
    --25962874(+) TTTTT-/GGGGGG 1 -- int10--------
    rs738795041,2
    C--25962883(+) GGGGGG/CTAGTA 1 -- int11Minor allele frequency- C:0.00WA 2
    rs2006704721,2
    C--25962883(+) GGGGG-/CTAGTA 1 -- int10--------
    rs169802391,2
    C,F,H--25962988(+) AGAACG/ATACTT 1 -- int120Minor allele frequency- A:0.25NA NS EA WA 1872
    rs1823685751,2
    --25963020(+) CCTTGG/TATGAA 1 -- int10--------

    HapMap Linkage Disequilibrium report for ADRBK2 (25960816 - 26125261 bp)

    Structural Variations
         Database of Genomic Variants (DGV) Selected variations for ADRBK2 (see all 19):    About this table    
    Variant IDTypeSubtypePubMed ID
    dgv828e199CNV Deletion23128226
    esv2724088CNV Deletion23290073
    esv2724087CNV Deletion23290073
    dgv778e201CNV Deletion23290073
    nsv436347CNV Deletion17901297
    nsv471189CNV Gain18288195
    nsv914952CNV Gain21882294
    esv26366CNV Gain19812545
    dgv175e55CNV Gain17911159
    nsv9892CNV Gain18304495

    Human Gene Mutation Database (HGMD): ADRBK2
    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing ADRBK2
    DNA2.0 Custom Variant and Variant Library Synthesis for ADRBK2

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 109636    OMIM disorders: --

    12 diseases for ADRBK2:    
    About MalaCards
    whim syndrome    cocaine abuse    bipolar disorder    schizoaffective disorder
    anorexia nervosa    retinoblastoma    schizophrenia    oral squamous cell carcinoma
    colorectal cancer    squamous cell carcinoma    neuronitis    malaria


    ADRBK2 for disorders           About GeneDecksing

    5 Novoseek inferred disease relationships for ADRBK2 gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    bipolar disorder 50.9 19 19766236 (3), 17106420 (2), 18075471 (2), 18359007 (2) (see all 7)
    retinoblastoma 23.9 2 11166332 (1)
    mania 22.4 1 12808434 (1)
    schizophrenia 6.31 9 15006433 (4), 17106420 (1)
    shock 0 2 17179467 (2)

    Genetic Association Database (GAD): ADRBK2
    Human Genome Epidemiology (HuGE) Navigator: ADRBK2 (14 documents)

    Export disorders for ADRBK2 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for ADRBK2 gene, integrated from 10 sources (see all 118):
    (articles sorted by number of sources associating them with ADRBK2)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Association analysis of GRK3 gene promoter variants in cocaine abuse. (PubMed id 17621168)1, 4, 9 Guindalini C....Breen G. (Psychiatr. Genet. 2007)
    2. Chromosome mapping of the human arrestin (SAG), beta-arrestin 2 (ARRB2), and beta-adrenergic receptor kinase 2 (ADRBK2) genes. (PubMed id 7695743)1, 3, 9 Calabrese G....De Blasi A. (Genomics 1994)
    3. Bipolar 1 disorder is not associated with the RGS4, PRODH, COMT and GRK3 genes. (PubMed id 17106420)1, 4, 9 Prata D.P....Collier D.A. (Psychiatr. Genet. 2006)
    4. Molecular cloning, functional expression and mRNA analysis of human beta-adrenergic receptor kinase 2. (PubMed id 8427589)1, 2, 9 Parruti G.... de Blasi A. (Biochem. Biophys. Res. Commun. 1993)
    5. Development and validation of a method for profiling post-translational modification activities using protein microarrays. (PubMed id 20596523)1, 2 Del RincA^n S.V....Spruck C. (PLoS ONE 2010)
    6. Association study of 182 candidate genes in anorexia nervosa. (PubMed id 20468064)1, 4 Pinheiro A.P....Woodside D.B. (Am. J. Med. Genet. B Neuropsychiatr. Genet. 2010)
    7. A large-scale candidate gene association study of age at menarche and age at natural menopause. (PubMed id 20734064)1, 4 He C....Hunter D.J. (Hum. Genet. 2010)
    8. Comprehensive copy number variant (CNV) analysis of neuronal pathways genes in psychiatric disorders identifies rare variants within patients. (PubMed id 20398908)1, 4 Saus E....Estivill X. (J Psychiatr Res 2010)
    9. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PubMed id 20379614)1, 4 Rose J.E....Uhl G.R. (Mol. Med. 2010)
    10. Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study. (PubMed id 20628086)1, 4 Bailey S.D....Anand S. (Diabetes Care 2010)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 157 HGNC: 290 AceView: ADRBK2 Ensembl:ENSG00000100077 euGenes: HUgn157
    ECgene: ADRBK2 Kegg: 157 H-InvDB: ADRBK2

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
    About This Section

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    NameDescription
    PharmGKB entry for ADRBK2 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for ADRBK2 gene:
    Search GeneIP for patents involving ADRBK2

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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