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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

ADRBK2 Gene

protein-coding   GIFtS: 66
GCID: GC22P025960

adrenergic, beta, receptor kinase 2
 Explore 8 diseases affiliated with
ADRBK2 via
MalaCards
our new
 Human Malady Compendium 
Biological research products
for ADRBK2    

Aliases
for ADRBK2 gene

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, and/or 10fRNAdb)
About This Section
Aliases
Adrenergic, Beta, Receptor Kinase 21 2     Beta-ARK-23
BARK21 2 3 5     Beta-Adrenergic Receptor Kinase 22
GRK31 2 3 5     Beta-ARK-23
G-Protein-Coupled Receptor Kinase 32 3     EC 2.7.118
EC 2.7.11.153 8     

External Ids:    HGNC: 2901   Entrez Gene: 1572   Ensembl: ENSG000001000777   OMIM: 1096365   UniProtKB: P356263   

Export aliases for ADRBK2 gene to outside databases

Previous GC identifers: GC22P022657 GC22P024169 GC22P024285 GC22P008764


Summaries
for ADRBK2 gene

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section
Entrez Gene summary for ADRBK2:
The beta-adrenergic receptor kinase specifically phosphorylates the agonist-occupied form of the beta-adrenergic and
related G protein-coupled receptors. Overall, the beta adrenergic receptor kinase 2 has 85% amino acid similarity with
beta adrenergic receptor kinase 1, with the protein kinase catalytic domain having 95% similarity. These data suggest
the existence of a family of receptor kinases which may serve broadly to regulate receptor function. (provided by
RefSeq, Jul 2008)

UniProtKB/Swiss-Prot: ARBK2_HUMAN, P35626
Function: Specifically phosphorylates the agonist-occupied form of the beta-adrenergic and closely related receptors

Gene Wiki entry for ADRBK2 (Beta adrenergic receptor kinase-2)


Genomic Views
for ADRBK2 gene

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000022.10  NC_018933.1  NT_011520.12  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the ADRBK2 gene promoter:
         AP-2alpha isoform 3   AP-2alpha isoform 2   AP-2alpha isoform 4   AP-2alpha   AP-2alphaA   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: ADRBK2 promoter sequence
   Search SABiosciences Chromatin IP Primers for ADRBK2

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat ADRBK2


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 22q12.1   Ensembl cytogenetic band:  22q12.1   HGNC cytogenetic band: 22q11

ADRBK2 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
ADRBK2 gene location

GeneLoc information about chromosome 22         GeneLoc Exon Structure

GeneLoc location for GC22P025960:  view genomic region     (about GC identifiers)

Start:
 25,960,816 bp from pter      End:
 26,125,259 bp from pter
Size:
 164,444 bases      Orientation:
 plus strand

Proteins
for ADRBK2 gene

(According to 1UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to 2PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section
UniProtKB/Swiss-Prot: ARBK2_HUMAN, P35626 (See protein sequence)
Recommended Name: Beta-adrenergic receptor kinase 2  
Size: 688 amino acids; 79710 Da
Secondary accessions: Q9UGW9

Explore the universe of human proteins at neXtProt for ADRBK2: NX_P35626

Post-translational modifications:

  • View modification sites using PhosphoSitePlus2
  • View neXtProt modification sites for NX_P35626

    • 4/23 DME Specific Peptides for ADRBK2 (P35626) (see all 23)
     VVYRDLK  CSHPFSK  YMAPEVL  LRGDIFQ 

    ADRBK2 Protein expression data from MOPED and PaxDb:    About this image 
    Estimated protein expression log10 (pmol).

    REFSEQ proteins: NP_005151.2  
    ENSEMBL proteins: 
     ENSP00000317578   ENSP00000393688  

    Human Recombinant Protein Products: 
    EMD Millipore Purified and/or Recombinant ADRBK2 Protein
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    Browse Proteins at Uscn


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    Browse ELISAs and CLIAs at Uscn

    Protein Domains /
    Families
    for ADRBK2 gene

    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    ADRBK2 for domains           About GeneDecksing

    5/11 InterPro domains/families (see all 11):
     IPR017441 Protein_kinase_ATP_BS
     IPR000239 GPCR_kinase
     IPR002290 Ser/Thr_dual-sp_kinase_dom
     IPR000961 AGC-kinase_C
     IPR011009 Kinase-like_dom

    Graphical View of Domain Structure for InterPro Entry P35626

    ProtoNet protein and cluster: P35626

    4 Blocks protein families:
    IPB000239 GPCR kinase signature
    IPB000342 Regulator of G-protein signalling (RGS) protein signature
    IPB000961 Protein kinase C-terminal domain
    IPB001849 Pleckstrin-like


    UniProtKB/Swiss-Prot: ARBK2_HUMAN, P35626
    Similarity: Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. GPRK subfamily
    Similarity: Contains 1 AGC-kinase C-terminal domain
    Similarity: Contains 1 PH domain
    Similarity: Contains 1 protein kinase domain
    Similarity: Contains 1 RGS domain


    Function
    for ADRBK2 gene

    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
    About This Section
    Function Summary:

         UniProtKB/Swiss-Prot: ARBK2_HUMAN, P35626
    Function: Specifically phosphorylates the agonist-occupied form of the beta-adrenergic and closely related receptors
    Catalytic activity: ATP + [beta-adrenergic receptor] = ADP + [beta-adrenergic receptor] phosphate

         Genatlas biochemistry entry for ADRBK2:
    beta-adrenergic receptor kinase 2

    Enzyme Numbers (IUBMB): EC 2.7.11.151 2 EC 2.7.112

    miRNA
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    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat ADRBK2
    8/93 QIAGEN miScript miRNA Assays for microRNAs that regulate ADRBK2 (see all 93):
    hsa-miR-3607-3p hsa-miR-15a hsa-miR-199a-3p hsa-miR-138-2* hsa-miR-519a hsa-miR-1244 hsa-miR-298 hsa-miR-376c
    Browse SwitchGear 3'UTR luciferase reporter plasmids
    Inhib. RNA
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    OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for ADRBK2 (see all 7)
    OriGene shRNA RFP: ADRBK2
    OriGene siRNA: ADRBK2
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat ADRBK2

    Gene Editing
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    Clone
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    Cell Line
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    Search LifeMap BioReagents cell lines for ADRBK2

    In Situ Assay
    Products:       
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    Gene Ontology (GO): 5 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0004672protein kinase activity TAS8427589
    GO:0004703G-protein coupled receptor kinase activity IEA--
    GO:0005524ATP binding IEA--
    GO:0005543phospholipid binding IEA--
    GO:0047696beta-adrenergic receptor kinase activity IEA--


    ADRBK2 for ontologies           About GeneDecksing


    5 GenomeRNAi human phenotypes for ADRBK2:
     Decreased focal adhesion (FA)   Decreased viability  Increased G1 DNA content  Increased cell death HMECs cel 
     Lamellipodia and high actin ra 

    Animal Models:
         Mouse knock-out Adrbk2tm1Rjl for ADRBK2
         1 MGI mutant phenotype (inferred from 1 allele) (MGI details for Adrbk2):
     taste/olfaction 

    ADRBK2 for phenotypes           About GeneDecksing


    Pathways & Interactions
    for ADRBK2 gene

    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
    About This Section

    Unified GeneCards pathways - 5/9 super-pathways (see all 9) About this table 
    See pathways by source

    Super-pathwaycontained gene-specific pathways
    1Development Angiotensin signaling via beta-Arrestin
    		Development Angiotensin signaling via beta-Arrestin1.00
    		Development_Angiotensin signaling via beta-Arrestin0.96
    2Chemokine Signaling
    		Chemokine Signaling1.00
    		Chemokine signaling pathway0.33
    3Opioid Signalling
    		Beta-agonist/Beta-blocker Pathway, Pharmacodynamics0.35
    		Glutamatergic synapse0.31
    4Diuretics Pathway, Pharmacodynamics
    		Diuretics Pathway, Pharmacodynamics1.00
    5IL-4 signaling Pathway
    		IL-4 signaling Pathway1.00

    Pathway sources
    See GeneCards unified pathways
    Show all pathways

    1 EMD Millipore Pathway for ADRBK2
        Development Angiotensin signaling via beta-Arrestin

    2 Downloadable PowerPoint Slides of QIAGEN Pathway Central Maps for ADRBK2
        Chemokine Signaling
    Colorectal Cancer Metastasis

    1 GeneGo (Thomson Reuters) Pathway for ADRBK2
        Development Angiotensin signaling via beta-Arrestin

    2 BioSystems Pathways for ADRBK2 
        IL-4 signaling Pathway
    Thromboxane A2 receptor signaling

    2 PharmGKB Pathways for ADRBK2
        Beta-agonist/Beta-blocker Pathway, Pharmacodynamics
    Diuretics Pathway, Pharmacodynamics

    4         Kegg Pathways  (Kegg details for ADRBK2):
        Chemokine signaling pathway
    Endocytosis
    Glutamatergic synapse
    Olfactory transduction


    ADRBK2 for pathways           About GeneDecksing

    Interactions:

        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for ADRBK2

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    5/373 Interacting proteins for ADRBK2 (P356263 ENSP000003175784) via UniProtKB, MINT, STRING, and/or I2D (see all 373)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    BDKRB2P304113, ENSP000003077134I2D: score=2 STRING: ENSP00000307713
    AGTR1P305563, ENSP000002734304I2D: score=1 STRING: ENSP00000273430
    OPRM1P353723, ENSP000003946244I2D: score=1 STRING: ENSP00000394624
    UBCP0CG483, ENSP000003448184I2D: score=1 STRING: ENSP00000344818
    CCR4P516793, ENSP000003326594I2D: score=2 STRING: ENSP00000332659
    About this table

    Gene Ontology (GO): 4 biological process terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006468protein phosphorylation ----
    GO:0007165signal transduction IEA--
    GO:0031623receptor internalization IDA--
    GO:0038032termination of G-protein coupled receptor signaling pathway IEA--


    ADRBK2 for ontologies           About GeneDecksing



    Drugs & Compounds
    for ADRBK2 gene

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section

    ADRBK2 for compounds           About GeneDecksing

    EMD Millipore small molecules for ADRBK2:
    Small Molecule - inhibitor
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for ADRBK2

    3 HMDB Compounds for ADRBK2    About this table
    CompoundSynonyms CAS #PubMed Ids
    ADPadenosindiphosphorsaeure (see all 8)58-64-0--
    Adenosine triphosphate5'-(tetrahydrogen triphosphate) Adenosine (see all 24)56-65-5--
    ZincZinc (see all 2)7440-66-6--

    1 DrugBank Compound for ADRBK2    About this table
    CompoundSynonyms CAS #TypeActionsPubMed Ids
    Adenosine triphosphate5'-ATP (see all 8)56-65-5target--17139284 17016423

    10/13 Novoseek chemical compound relationships for ADRBK2 gene (see all 13)    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    damgo 48.2 5 12750434 (3), 11299306 (1), 10092593 (1)
    geldanamycin 43.9 6 17179467 (3)
    pip2 42.6 3 8798768 (2)
    epinephrine 38.5 17 17255468 (4), 15192083 (3), 15456839 (2), 16533872 (1) (see all 5)
    ionomycin 21.3 1 17179467 (1)
    methamphetamine 21.2 2 17621168 (1)
    alanine 18.7 1 9849959 (1)
    propranolol 7.55 2 12642394 (1), 17255468 (1)
    isoproterenol 5.38 1 12020767 (1)
    oligonucleotide 0 1 11247813 (1)

    Search CenterWatch for drugs/clinical trials and news about ADRBK2 / ARBK2 

    Transcripts
    for ADRBK2 gene

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section
    REFSEQ mRNAs for ADRBK2 gene: 
    NM_005160.3  

    Unigene Cluster for ADRBK2:

    Adrenergic, beta, receptor kinase 2
    Hs.657494  [show with all ESTs]
    Unigene Representative Sequence: NM_005160
    2 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000324198(uc010gux.3 uc003abw.2 uc003abx.4 uc003aby.4)
    ENST00000455558

    miRNA
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    8/93 QIAGEN miScript miRNA Assays for microRNAs that regulate ADRBK2 (see all 93):
    hsa-miR-3607-3p hsa-miR-15a hsa-miR-199a-3p hsa-miR-138-2* hsa-miR-519a hsa-miR-1244 hsa-miR-298 hsa-miR-376c
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    Clone
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    Additional cDNA sequence: 

    AK055687.1 AK058103.1 AK123767.1 AK124922.1 AK292234.1 AK310398.1 BC021221.2 BC029563.1 
    BC036797.1 BC063545.1 X69117.1 

    14 DOTS entries:

    DT.314219  DT.120646222  DT.413854  DT.120646260  DT.91871442  DT.95269662  DT.100732870  DT.99992562 
    DT.100639923  DT.91673436  DT.95161733  DT.100774370  DT.91891950  DT.99945421 

    24/198 AceView cDNA sequences (see all 198):

    H55606 AA741445 BF056793 BG058574 AA257973 BC036797 AV720235 AV720497 
    CA418731 N38770 CA849005 BC063545 BX645400 BX390226 BF056176 BX104431 
    CA844322 AA322997 AA830671 AW630342 BM310555 AA278408 F07794 CB243004 

    GeneLoc Exon Structure

    4 Alternative Splicing Database (ASD) splice patterns (SP) for ADRBK2    About this scheme

    ExUns: 1 ^ 2 ^ 3 ^ 4a · 4b · 4c ^ 5 ^ 6 ^ 7 ^ 8 ^ 9a · 9b · 9c ^ 10 ^ 11 ^ 12 ^ 13 ^ 14a · 14b ^ 15 ^ 16 ^ 17 ^ 18 ^ 19 ^ 20 ^ 21 ^
    SP1:                    -     -                 -                                         -                                                                     
    SP2:                                                                                                                                                            
    SP3:                                            -                                                                                                               
    SP4:                                                                                                                                                            

    ExUns: 22 ^ 23 ^ 24
    SP1:                  
    SP2:                  
    SP3:                  
    SP4:                  


    ECgene alternative splicing isoforms for ADRBK2

    Expression
    for ADRBK2 gene

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    ADRBK2 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS
    CGAP TAG: ACTGAAACTT

    Microarray
    RNAseq (Illumina Body Map)
    (100×FPKM)½
    SAGE (Serial Analysis of Gene Expression)
    About this image

    ADRBK2 expression in embryonic tissues and stem cells
    Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine    About this table
    2 LifeMap In Vivo Development Anatomical Compartments/Cells 
    Tissue Anatomical Compartment CellCategory (developmental path)
    Spinal CordSpinal Ventral ColumnsVentral Spinal Cord Progenitor CellsMotor Neurons
    Spinal CordSpinal Ventral ColumnsSpinal Cord
    Expression: Positive    Negative     Selective marker
    Experimental details: Curated     Microarrays     In-situ hybridization

    See ADRBK2 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for ADRBK2

    SOURCE GeneReport for Unigene cluster: Hs.657494
        SABiosciences Custom PCR Arrays for ADRBK2
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    In Situ
    Assay Products:     
         		Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ADRBK2

    Orthologs
    for ADRBK2 gene

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section
    This gene was present in the common ancestor of animals.

    Orthologs for ADRBK2 gene from 5/22 species (see all 22)    About this table
    Organism Taxonomic
    classification    		 Gene Description Human
    Similarity    		 Orthology
    Type    		 Details
    chicken
    (Gallus gallus)    		 Aves ADRBK21 adrenergic, beta, receptor kinase 2 82.82(n)
    93.34(a)    		   416904  XM_415195.3  XP_415195.3 
    lizard
    (Anolis carolinensis)    		 Reptilia ADRBK26
    		 --
    		 82(a)
    		 1 ↔ 1
    		 AAWZ02041337(1634-5259)
    zebrafish
    (Danio rerio)    		 Actinopterygii adrbk21 adrenergic, beta, receptor kinase 2 76.26(n)
    90.55(a)    		   569403  NM_001134725.1  NP_001128197.1 
    fruit fly
    (Drosophila melanogaster)    		 Insecta Gprk11 , 3 protein amino acid phosphorylation protein
    serine/threonine more3
    G protein-coupled receptor kinase 11    		 66(a)3
    62.96(n)1
    68.12(a)1    		   33550131  NM_001169580.11  NP_001163051.11 
    worm
    (Caenorhabditis elegans)    		 Secernentea W02B3.23
    grk-21    		 G-protein coupled receptor3
    Protein GRK-21    		 69(a)3
    63.67(n)1
    68.04(a)1    		   III(676123-680041)3
    1752231  NM_064834.31  NP_497235.21 


    ENSEMBL Gene Tree for ADRBK2 (if available)
    TreeFam Gene Tree for ADRBK2 (if available) 

    Paralogs
    for ADRBK2 gene

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for ADRBK2 gene
    GRK72  GRK52  GRK12  ADRBK12  GRK42  GRK62  
    11 SIMAP similar genes for ADRBK2 using alignment to 4 protein entries:     ARBK2_HUMAN (see all proteins):
    ADRBK1    AKT2    PRKAA1    GRK5    GRK4    SGK2
    GRK7    PRKACG    SGK1    GRK1    GRK6

    ADRBK2 for paralogs           About GeneDecksing


    2 Pseudogenes.org Pseudogenes for ADRBK2
    PGOHUM00000246547 PGOHUM00000246550


    Genomic Variants
    for ADRBK2 gene

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/2763 NCBI SNPs in ADRBK2 are shown (see all 2763)     About this table
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance    		Chr 22 posSequence#AA
    Chg    		TypeMore#Allele
    freq    		PopTotal
    sample    		More
    ----------
    rs1875119841,2
    		C,unknown26062914(+) GGAAAA/GCTGAT 1 -- int10--------
    rs57611221,2
    		C,F,A,H,--25959309(+) CCTTCG/AACTGC 2 -- us2k1 int111Minor allele frequency- A:0.16NS EA NA WA CSA 548
    rs1881728721,2
    		--25959314(+) AACTGC/TCATTC 2 -- int1 us2k10--------
    rs1929202381,2
    		--25959456(+) GTGGCA/GTGGGA 2 -- us2k1 int10--------
    rs1850109801,2
    		--25959529(+) TTACAA/TGAAAT 2 -- int1 us2k10--------
    rs1451160881,2
    		C,--25959866(+) AAATT-/CCCCCC 2 -- int1 us2k10--------
    rs1874357181,2
    		--25959867(+) AAATTA/CCCCCC 2 -- us2k1 int10--------
    rs1923887071,2
    		--25959973(+) TGTATG/TGACCG 2 -- us2k1 int10--------
    rs1847985781,2
    		--25959986(+) AAACCC/TTAACG 2 -- us2k1 int10--------
    rs1148462331,2
    		F,--25959990(+) CCTAAC/GGACAG 2 -- us2k1 int11Minor allele frequency- G:0.04WA 118

    HapMap Linkage Disequilibrium report for ADRBK2 (25960816 - 26125259 bp)
    Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
    Database of Genomic Variants (DGV): 12 variations for ADRBK2
         12 CNVs: 8904 31085 29717 73806 53668 31086 34486 0819 3239 2272 34487 8903
    Human Gene Mutation Database (HGMD): ADRBK2

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    Disorders / Diseases
    for ADRBK2 gene

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    ADRBK2 for disorders           About GeneDecksing

    OMIM gene information: 109636    OMIM disorders: --

    8 diseases for ADRBK2:    About MalaCards
    cocaine abuse    whim syndrome    anorexia nervosa    bipolar disorder
    retinoblastoma    schizophrenia    neuronitis    colorectal cancer

    5 Novoseek disease relationships for ADRBK2 gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    bipolar disorder 50.9 19 19766236 (3), 17106420 (2), 18075471 (2), 18359007 (2) (see all 7)
    retinoblastoma 23.9 2 11166332 (1)
    mania 22.4 1 12808434 (1)
    schizophrenia 6.31 9 15006433 (4), 17106420 (1)
    shock 0 2 17179467 (2)

    Human Genome Epidemiology (HuGE) Navigator: ADRBK2 (14 documents)

    Export disorders for ADRBK2 gene to outside databases

    Publications
    for ADRBK2 gene

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for ADRBK2 gene, integrated from 9 sources (see all 116):
    (articles sorted by number of sources associating them with ADRBK2)    		    Utopia: connect your pdf to the dynamic
    world of online information

    1. Chromosome mapping of the human arrestin (SAG), beta-arrestin 2 (ARRB2), and beta-adrenergic receptor kinase 2 (ADRBK2) genes. (PubMed id 7695743)1, 3, 9 Calabrese G....De Blasi A. (1994)
    2. Molecular cloning, functional expression and mRNA analysis of human beta-adrenergic receptor kinase 2. (PubMed id 8427589)1, 2, 9 Parruti G.... de Blasi A. (1993)
    3. The DNA sequence of human chromosome 22. (PubMed id 10591208)1, 2 Dunham I....O'Brien K.P. (1999)
    4. Allele specific analysis of the ADRBK2 gene in lympho blastoid cells from bipolar disorder patients. (PubMed id 19766236)1, 9 McCarthy M.J....Turner E.E. (2010)
    5. Evidence that a single nucleotide polymorphism in the promoter of the G protein receptor kinase 3 gene is associated with bipolar disorder. (PubMed id 12808434)1, 9 Barrett T.B....Kelsoe J.R. (2003)
    6. Leukocyte analysis from WHIM syndrome patients reveals a pivotal role for GRK3 in CXCR4 signaling. (PubMed id 18274673)1, 9 Balabanian K....Bachelerie F. (2008)
    7. Further evidence for association of GRK3 to bipolar disorder suggests a second disease mutation. (PubMed id 18075471)1, 9 Barrett T.B....Kelsoe J.R. (2007)
    8. Association analysis of GRK3 gene promoter variants in cocaine abuse. (PubMed id 17621168)1, 9 Guindalini C....Breen G. (2007)
    9. beta-Adrenoceptor and GRK3 expression in human lympho cytes is related to blood pressure and urinary albumin excretion. (PubMed id 20216086)1, 9 Oliver E....D'Ocon P. (2010)
    10. Promoter variant in the GRK3 gene associated with bipolar disorder alters gene expression. (PubMed id 18359007)1, 9 Zhou X....Kelsoe J.R. (2008)

    External Searches for ADRBK2 gene

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Disorders
    Free Text  
      Query String
    		PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    Genome Databases showing ADRBK2 gene

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 157 HGNC: 290 AceView: ADRBK2 Ensembl:ENSG00000100077 euGenes: HUgn157
    ECgene: ADRBK2 Kegg: 157 H-InvDB: ADRBK2

    Other Databases showing ADRBK2 gene

    (According to HUGE)
    About This Section
    		   --

    Specialized Databases showing ADRBK2 gene

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for ADRBK2 Pharmacogenomics, SNPs, Pathways

    Intellectual Property
    for ADRBK2 gene

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    		Patent Information for ADRBK2 gene:
    Search GeneIP for patents involving ADRBK2

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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    About This Section

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