ADRBK1 Gene
protein-coding GIFtS: 67
GCID: GC11P067033
|
|
adrenergic, beta, receptor kinase 1
| |
Aliases
for ADRBK1 gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| Adrenergic, Beta, Receptor Kinase 11 2 | | Beta-ARK-13 | | BARK11 2 3 | | Beta-Adrenergic Receptor Kinase 12 | | GRK21 2 3 | | BARK3 | | G-Protein Coupled Receptor Kinase 22 3 | | Beta-ARK-13 | | EC 2.7.11.153 8 | | EC 2.7.118 | | BETA-ARK12 | | |
Export aliases for ADRBK1 gene to outside databasesPrevious GC identifers: GC11P069548 GC11M068669 GC11P067284 GC11P066809 GC11P066790 GC11P063362 |
Summaries
for ADRBK1 gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
Entrez Gene summary for ADRBK1:
The product of this gene phosphorylates the beta-2-adrenergic receptor and appears to mediate agonist-specificdesensitization observed at high agonist concentrations. This protein is an ubiquitous cytosolic enzyme thatspecifically phosphorylates the activated form of the beta-adrenergic and related G-protein-coupled receptors.Abnormal coupling of beta-adrenergic receptor to G protein is involved in the pathogenesis of the failing heart.(provided by RefSeq, Jul 2008)
UniProtKB/Swiss-Prot: ARBK1_HUMAN, P25098Function: Specifically phosphorylates the agonist-occupied form of the beta-adrenergic and closely related receptors,probably inducing a desensitization of them. Key regulator of LPAR1 signaling. Competes with RALA for binding to LPAR1thus affecting the signaling properties of the receptor. Desensitizes LPAR1 and LPAR2 in a phosphorylation-independentmanner
 summary
for ADRBK1: Beta-adrenergic receptor kinase 1 (ADRBK1, also known as GRK2) phosphorylates the activated form of the beta
adrenergic receptor, thus acting as a form of negative feedback.
Gene Wiki entry for ADRBK1 (Beta adrenergic receptor kinase)
|
Genomic Views
for ADRBK1 gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000011.9 NC_018922.1 NT_167190.1
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the ADRBK1 gene promoter:
Sp1 AP-2alpha isoform 3 AP-2alpha isoform 2 CREB NF-AT2 deltaCREB AP-2alpha isoform 4 AP-2alpha AP-2alphaA NF-AT1
Other transcription factors
Search SABiosciences Chromatin IP Primers for ADRBK1
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat ADRBK1 |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 11q13.1 Ensembl cytogenetic band: 11q13.2 HGNC cytogenetic band: 11q13ADRBK1 Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 11 GeneLoc Exon Structure GeneLoc location for GC11P067033: view genomic region
(about GC identifiers)
Start:
|
67,033,881 bp from pter |
End:
|
67,054,029 bp from pter |
Size:
|
20,149 bases |
Orientation:
|
plus strand |
|
Proteins
for ADRBK1 gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: ARBK1_HUMAN, P25098 (See
protein sequence)Recommended Name: Beta-adrenergic receptor kinase 1 Size: 689 amino acids; 79574 Da
Subunit: Interacts with GIT1 (By similarity). Interacts with, and phosphorylates chemokine-stimulated CCR5. Interactswith ARRB1. Interacts with LPAR1 and LPAR2. Interacts with RALA in response to LPAR1 activation. ADRBK1 and RALAmutually inhibit each other's binding to LPAR1
5 PDB 3D structures from  and Proteopedia  for ADRBK1:1BAK (3D)
3CIK (3D)
3KRW (3D)
3KRX (3D)
3V5W (3D)
Secondary accessions: B0ZBE1 Q13837 Q6GTT3Explore the universe of human proteins at neXtProt for ADRBK1: NX_P25098
Post-translational modifications:
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_P25098
4/32 DME Specific Peptides for ADRBK1 (P25098) (see all 32)
ADRBK1 Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins: NP_001610.2
ENSEMBL proteins: ENSP00000312262 ENSP00000434126 Reactome Protein details: P25098
Human Recombinant Protein Products:
Gene Ontology (GO): 5/13 cellular component terms (GO ID links to tree view) (see all 13): About this table
ADRBK1 for ontologies About GeneDecksing
ADRBK1 Antibody Products:
Assay Products for ADRBK1: |
Protein
Domains /
Families
for ADRBK1 gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
ADRBK1 for domains About GeneDecksing
5/11 InterPro domains/families (see all 11):Graphical View of Domain Structure for InterPro Entry P25098ProtoNet protein and cluster: P25098 4 Blocks protein families: IPB000239 GPCR kinase signature IPB000342 Regulator of G-protein signalling (RGS) protein signature IPB000961 Protein kinase C-terminal domain IPB001849 Pleckstrin-like
UniProtKB/Swiss-Prot: ARBK1_HUMAN, P25098Similarity: Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. GPRK subfamilySimilarity: Contains 1 AGC-kinase C-terminal domainSimilarity: Contains 1 PH domainSimilarity: Contains 1 protein kinase domainSimilarity: Contains 1 RGS domain |
Function
for ADRBK1 gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Function Summary:
UniProtKB/Swiss-Prot: ARBK1_HUMAN, P25098Function: Specifically phosphorylates the agonist-occupied form of the beta-adrenergic and closely related receptors,probably inducing a desensitization of them. Key regulator of LPAR1 signaling. Competes with RALA for binding to LPAR1thus affecting the signaling properties of the receptor. Desensitizes LPAR1 and LPAR2 in a phosphorylation-independentmannerCatalytic activity: ATP + [beta-adrenergic receptor] = ADP + [beta-adrenergic receptor] phosphate Genatlas biochemistry entry for ADRBK1:beta-adrenergic receptor kinase 1,containing a CGG repeat in the 5'utr
Enzyme Numbers (IUBMB): EC 2.7.11.151 2 EC 2.7.112
Clone
Products: |  | Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore | |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for ADRBK1 (see all 3)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for ADRBK1
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling 
| |  | GenScript: all cDNA clones in your preferred vector: ADRBK1 (NM_001619) | |  | Browse Sino Biological Human cDNA Clones | |  | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for ADRBK1 | |  | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat ADRBK1 |
In Situ Assay
Products: |
 | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ADRBK1 |
Gene Ontology (GO): 5/9 molecular function terms (GO ID links to tree view) (see all 9): About this table
ADRBK1 for ontologies About GeneDecksing
6 GenomeRNAi human phenotypes for ADRBK1:
Animal Models:
Mouse knock-outs for ADRBK1: Adrbk1tm1Mca Adrbk1tm1.1Gwd
11 MGI mutant phenotypes (inferred from 3 alleles ) (MGI details for Adrbk1):
ADRBK1 for phenotypes About GeneDecksing
|
Pathways & Interactions
for ADRBK1 gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Unified GeneCards pathways - 5/19 super-pathways (see all 19) About this table
See pathways by source
| Super-pathway | contained gene-specific pathways |
|---|
| 1 | Signaling by FGFR | | | 2 | DAG and IP3 signaling | | | 3 | Opioid Signalling | | | 4 | Signaling by GPCR | | | 5 | Immune System | |
Pathway sources
See GeneCards unified pathways
Show all pathways
2 EMD Millipore Pathways for ADRBK1
3 Downloadable PowerPoint Slides of QIAGEN Pathway Central Maps for ADRBK1
1 
Cell Signaling Technology (CST) Pathway for ADRBK1
2  GeneGo (Thomson Reuters) Pathways for ADRBK1
4  BioSystems Pathways for ADRBK1
5/31 
Reactome Pathways for ADRBK1 (see all 31)
2  PharmGKB Pathways for ADRBK1
3 
Kegg Pathways (Kegg details for ADRBK1):
ADRBK1 for pathways About GeneDecksing
Interactions:
SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for ADRBK1
STRING Interaction
Network Preview (showing 5 interactants - click image to see 25)
5/180 Interacting proteins for ADRBK1 (P250981, 2, 3 ENSP000003122624) via UniProtKB, MINT, STRING, and/or I2D (see all 180)| Interactant | Interaction Details |
|---|
| GeneCard | External ID(s) |
|---|
| GIT1 | Q9Y2X72, 3, ENSP000003783384 | MINT-6608788 MINT-6608890 MINT-6608906 MINT-6608861 MINT-6608921 I2D:
score=3 STRING: ENSP00000378338 | | MDM2 | Q009872, 3, ENSP000004172814 | MINT-3376083 MINT-3376121 MINT-3376102 MINT-3376147 I2D:
score=2 STRING: ENSP00000417281 | | FPR1 | P214621, 3, ENSP000003027074 | EBI-3904795,EBI-2869495 I2D:
score=1 STRING: ENSP00000302707 | | CSNK2B | P678702, 3 | MINT-8253000 I2D:
score=2 | | UBC | P0CG482, 3, ENSP000003448184 | MINT-3376233 MINT-3376168 MINT-3376202 I2D:
score=1 STRING: ENSP00000344818 |
About this table
Gene Ontology (GO): 5/25 biological process terms (GO ID links to tree view) (see all 25): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0002026 | regulation of the force of heart contraction |
-- | -- | | GO:0002029 | desensitization of G-protein coupled receptor protein signaling pathway |
ISS | -- | | GO:0003108 | negative regulation of the force of heart contraction by chemical signal |
IMP | 15051637 | | GO:0006468 | protein phosphorylation |
-- | -- | | GO:0006979 | response to oxidative stress |
-- | -- |
ADRBK1 for ontologies About GeneDecksing
|
Drugs & Compounds
for ADRBK1 gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
ADRBK1 for compounds About GeneDecksing
Compounds for ADRBK1 available from Tocris Bioscience About this table
| Compound | Action |
CAS
# |
|---|
| GRK2i | GRK2 inhibitory polypeptide. Gbetagamma antagonist | [148505-03-7] |
3 HMDB Compounds for ADRBK1 About this table
1 DrugBank Compound for ADRBK1 About this table
10/48 Novoseek chemical compound relationships for ADRBK1 gene (see all 48) About this table
| Compound |
-log (P-Val) |
Hits |
PubMed IDs for Articles with Shared Sentences (# sentences) |
| etorphine |
69 |
8 |
18395423 (2), 10999950 (1) |
| threonine |
58.9 |
6 |
18649053 (1), 15375164 (1), 11527375 (1), 19846537 (1) (see all 5) |
| serine |
52.4 |
17 |
15205374 (1), 14557268 (1), 18649053 (1), 15749741 (1) (see all 12) |
| isoproterenol |
48.7 |
21 |
16356165 (4), 16856836 (2), 16385076 (1), 18034461 (1) (see all 9) |
| phosphoinositide |
41 |
8 |
16885398 (2), 11259422 (2), 9211925 (1), 16807128 (1) |
| alprenolol |
40.3 |
1 |
15192083 (1) |
| gf 109203x |
39.6 |
2 |
12023974 (1), 15182196 (1) |
| pip2 |
38.3 |
7 |
8798768 (3), 8798423 (3) |
| forskolin |
37.5 |
6 |
15155843 (1), 12372804 (1), 7559596 (1), 18451066 (1) |
| tyrosine |
35.6 |
50 |
16725308 (4), 10567420 (4), 12381737 (3), 15375164 (2) (see all 17) |
Search CenterWatch for drugs/clinical trials and news about ADRBK1 / ARBK1
|
Transcripts
for ADRBK1 gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for ADRBK1 gene: NM_001619.3 Unigene Cluster for ADRBK1: Adrenergic, beta, receptor kinase 1 Hs.83636 [show with all ESTs]Unigene Representative Sequence: NM_00161914 Ensembl transcripts including schematic representations, and UCSC links where relevant: ENST00000308595(uc009yrn.1) ENST00000526285 ENST00000530291 ENST00000416281
ENST00000529738 ENST00000533077 ENST00000534651 ENST00000532099 ENST00000526572
ENST00000527176 ENST00000529815 ENST00000531390 ENST00000532611 ENST00000524899
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for ADRBK1 (see all 3)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for ADRBK1
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript: all cDNA clones in your preferred vector: ADRBK1 (NM_001619) | | | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for ADRBK1 | | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat ADRBK1 |
Additional cDNA sequence: BC037963.1 BC090863.1 BC127253.1 M80776.1 X61157.1 21 DOTS entries: DT.95365634 DT.100789070 DT.101984390 DT.40117353 DT.101972063 DT.97860674 DT.100789069 DT.86856201 DT.444882 DT.92454573 DT.95205596 DT.92454587 DT.100038221 DT.95174908 DT.95365632 DT.120691856 DT.92454574 DT.92454607 DT.95365620 DT.100689804 DT.120691823 24/486 AceView cDNA sequences (see all 486): BQ955636 BU191678 AW806763 CD671377 BC037963 BE513285 BE764756 AI276436 AW806794 BM463298 AI670045 BF346000 AI916030 BI224925 AL559599 BQ083027 BE140522 BQ212135 BQ448312 BM551059 BQ226093 BM975379 BM561607 BQ083826
GeneLoc Exon Structure
5/11 Alternative Splicing Database (ASD) splice patterns (SP) for ADRBK1 (see all 11) About this scheme
| ExUns: | 1 | ^ | 2a | · | 2b | ^ | 3 | ^ | 4a | · | 4b | ^ | 5a | · | 5b | ^ | 6 | ^ | 7 | ^ | 8a | · | 8b | ^ | 9a | · | 9b | ^ | 10 | ^ | 11a | · | 11b | ^ | 12a | · | 12b | ^ | 13 | ^ | 14a | · | 14b | ^ | 15 | ^ | 16 | ^ | 17a | · | 17b | · |
|---|
|
| SP1: | | | - | | | | | | | | | | | | | | | | | | - | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | - | | |
| SP2: | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | - | | | | | | |
| SP3: | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | - | | - | | | | | | | | | | | | | | - | | |
| SP4: | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | |
| SP5: | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | |
| ExUns: | 17c | ^ | 18a | · | 18b | · | 18c | · | 18d | ^ | 19a | · | 19b | · | 19c | ^ | 20a | · | 20b | ^ | 21a | · | 21b | ^ | 22a | · | 22b |
|---|
|
| SP1: | - | | - | | | | | | | | | | | | | | | | | | | | | | | | | | |
| SP2: | | | | | | | | | | | | | | | | | | | | | | | | | | | | | |
| SP3: | - | | - | | | | | | | | | | | | | | | | | | | | | | | | | | |
| SP4: | | | | | | | | | | | | | | | | | | | | | | | | | | | | | |
| SP5: | | | | | | | | | | | | | | | | | | | | | | | | | | | | |
ECgene alternative splicing isoforms for ADRBK1
|
Expression
for ADRBK1 gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| ADRBK1 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: CCCCCTCGTG
About this image
See ADRBK1 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for ADRBK1
SOURCE GeneReport for Unigene cluster: Hs.83636
UniProtKB/Swiss-Prot: ARBK1_HUMAN, P25098Tissue specificity: Expressed in peripheral blood leukocytes
SABiosciences Custom PCR Arrays for ADRBK1
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for ADRBK1
Browse OriGene validated miRNA SYBR primer pairs
| | | SABiosciences RT2 qPCR Primer Assay in human, mouse, rat ADRBK1 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat ADRBK1 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat ADRBK1 | In Situ
Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ADRBK1 |
Orthologs
for ADRBK1 gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
This gene was present in the common ancestor of animals.
Orthologs for ADRBK1 gene from 4/18 species (see all 18) About this table
| Organism |
Taxonomic
classification |
Gene |
Description |
Human
Similarity |
Orthology
Type |
Details |
chicken
(Gallus gallus) |
Aves |
ADRBK11 |
adrenergic, beta, receptor kinase 1 |
85.42(n)
92.15(a) |
|
426000 NM_001031353.1 NP_001026524.1 |
lizard
(Anolis carolinensis) |
Reptilia |
ADRBK16 |
-- |
92(a) |
1 ↔ 1 |
1(92749810-92781716) |
fruit fly
(Drosophila melanogaster) |
Insecta |
Gprk13 |
protein amino acid phosphorylation protein
serine/threonine more |
66(a) |
|
-- |
worm
(Caenorhabditis elegans) |
Secernentea |
W02B3.23 |
G-protein coupled receptor |
63(a) |
|
III(676123-680041) -- |
ENSEMBL Gene Tree for ADRBK1 (if available)
TreeFam Gene Tree for ADRBK1 (if available) |
Paralogs
for ADRBK1 gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| Paralogs for ADRBK1 gene
- GRK72 ADRBK22 GRK52 GRK12 GRK42 GRK62
18/32 SIMAP similar genes for ADRBK1 using alignment to 2 protein entries: ARBK1_HUMAN (see all proteins)
(see all similar genes):ADRBK2 RPS6KA2 STK32A PRKCH STK11 RPS6KA3
CAMK1 DKFZp564L2416 MAP4K5 SGK2 PRKACB SGK3
GRK5 KIN27 PRKACA STK32B AKT3 PRKAA1
ADRBK1 for paralogs About GeneDecksing
|
Genomic Variants
for ADRBK1 gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr 11 pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
|---|
HapMap Linkage Disequilibrium report for ADRBK1 (67033881 - 67054029 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV) variations for ADRBK1: -- | SABiosciences Cancer Mutation PCR Assays |
| | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing ADRBK1 |
|
Disorders
/ Diseases
for ADRBK1 gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database, Novoseek,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
ADRBK1 for disorders About GeneDecksing
OMIM gene information: 109635
OMIM disorders: --
20/31  diseases for ADRBK1 (see all 31): About MalaCardsmajor depressive disorder myocardial infarction atrial fibrillation anorexia nervosa
allergic encephalomyelitis portal hypertension encephalomyelitis rheumatoid arthritis
chronic pain insulin resistance hypertension bipolar disorder
alzheimer's disease multiple sclerosis skin cancer parkinson's disease
arthritis pertussis thyroid carcinoma prostatitis
10/23 Novoseek disease relationships for ADRBK1 gene (see all 23) About this table
| Disease |
-log (P-Val) |
Hits |
PubMed IDs for Articles with Shared Sentences (# sentences) |
| heart failure |
50.2 |
54 |
17322894 (4), 20501412 (3), 16678578 (3), 11331748 (3) (see all 26) |
| cardiac function impaired |
37.8 |
3 |
15242731 (1), 10441103 (1) |
| cardiomyopathy |
18.5 |
1 |
16412044 (1) |
| cardiac hypertrophy |
14 |
4 |
18797934 (1), 9931137 (1), 19229505 (1) |
| heart failure congestive |
11.3 |
4 |
20128603 (1) |
| hypertrophy |
8.55 |
2 |
10790351 (1), 15097244 (1), 17573483 (1) |
| necrosis |
5.12 |
2 |
10790351 (1), 16385076 (1) |
| cancer |
0.534 |
1 |
18451066 (1) |
| tumors |
0.41 |
4 |
14665717 (1), 10790351 (1), 12869546 (1), 16385076 (1) |
| hypertension portal |
0 |
1 |
16530538 (1) |
Human Genome Epidemiology (HuGE) Navigator: ADRBK1 (8 documents)
Export disorders for ADRBK1 gene to outside databases
|
Publications
for ADRBK1 gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for ADRBK1 gene, integrated from 9 sources (see all 416):
(articles sorted by number of sources associating them with ADRBK1) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- cDNA cloning and chromosomal localization of the human beta- adrenergic receptor kinase. (PubMed id 2037065)1, 2, 3 Benovic J.L....Lefkowitz R.J. (1991)
- Monocyte chemoattractant protein-1-induced CCR2B receptor desensitization mediated by the G protein-coupled receptor kinase 2. (PubMed id 9501202)1, 2, 9 Aragay A.M.... Mayor F. Jr. (1998)
- Differential effects of CC chemokines on CC chemokine receptor 5 (CCR5) phosphorylation and identification of phosphorylation sites on the CCR5 carboxyl terminus. (PubMed id 10085131)1, 2, 9 Oppermann M....Olbrich H. (1999)
- The solution structure and dynamics of the pleckstrin homology domain of G protein-coupled receptor kinase 2 (beta-adrenergic receptor kinase 1). A binding partner of Gbetagamma subunits. (PubMed id 9446593)1, 2, 9 Fushman D....Cowburn D. (1998)
- Dual regulation of lysophosphatidic acid (LPA1) receptor signalling by Ral and GRK. (PubMed id 19306925)1, 2 Aziziyeh A.I....Bhattacharya M. (2009)
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
- Structure of the human gene encoding the beta-adrenergic receptor kinase. (PubMed id 8195124)1, 2 Penn R.B. and Benovic J.L. (1994)
- High expression of beta-adrenergic receptor kinase in human peripheral blood leukocytes. Isoproterenol and platelet activating factor can induce kinase translocation. (PubMed id 1339451)1, 2 Chuang T.T.... de Blasi A. (1992)
- The G protein coupled receptor kinase 2 plays an esse ntial role in beta-adrenergic receptor-induced insulin resistance. (PubMed id 19620130)1, 9 Cipolletta E....Iaccarino G. (2009)
- G protein-coupled receptor kinase 2 (GRK2) modulation and cell cycle progression. (PubMed id 20080565)1, 9 Penela P....Mayor F. (2010)
|
External Searches for ADRBK1 gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
|
|
Genome Databases showing ADRBK1 gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing ADRBK1 gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing ADRBK1 gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
|
About This Section
| Patent Information for ADRBK1 gene:
Search GeneIP for patents involving ADRBK1
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for ADRBK1 gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences),
In Situ Hybridization Assays from
Advanced Cell Diagnostics
About This Section
|
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| | |  | OriGene Antibodies for ADRBK1 | | OriGene shRNA RFP for ADRBK1 | | | OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for ADRBK1 | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for ADRBK1 | | | OriGene Protein Over-expression Lysate for ADRBK1 | | Browse OriGene Fluorogenic Cell Assay Kits | | | OriGene siRNA for ADRBK1 | | OriGene 3'-UTR Clone for ADRBK1 | | | OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for ADRBK1 | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for ADRBK1 | | | Browse OriGene GFP tagged cDNA clones in CMV expression vector | | Browse OriGene MicroRNA Expression Plasmids | | | Browse OriGene basic RS shRNAs | | Browse OriGene validated miRNA SYBR primer pairs | | | OriGene Purified Protein for ADRBK1 | | OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
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|  |  |  | | | | ThermoFisher Antibody for ADRBK1 |
| | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat ADRBK1 |
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