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ADRBK1 Gene

protein-coding   GIFtS: 72
GCID: GC11P067033

Adrenergic, Beta, Receptor Kinase 1

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(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Adrenergic, Beta, Receptor Kinase 11 2     beta-ARK-12
BARK12 3     Beta-Adrenergic Receptor Kinase 12
GRK22 3     BARK3
G-Protein Coupled Receptor Kinase 22 3     Beta-ARK-13
EC 2.7.11.153 8     EC 2.7.118
BETA-ARK12     

External Ids:    HGNC: 2891   Entrez Gene: 1562   Ensembl: ENSG000001730207   OMIM: 1096355   UniProtKB: P250983   

Export aliases for ADRBK1 gene to outside databases

Previous GC identifers: GC11P069548 GC11M068669 GC11P067284 GC11P066809 GC11P066790 GC11P063362


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for ADRBK1 Gene:
The product of this gene phosphorylates the beta-2-adrenergic receptor and appears to mediate agonist-specific
desensitization observed at high agonist concentrations. This protein is an ubiquitous cytosolic enzyme that
specifically phosphorylates the activated form of the beta-adrenergic and related G-protein-coupled receptors.
Abnormal coupling of beta-adrenergic receptor to G protein is involved in the pathogenesis of the failing heart.
(provided by RefSeq, Jul 2008)

GeneCards Summary for ADRBK1 Gene:
ADRBK1 (adrenergic, beta, receptor kinase 1) is a protein-coding gene. Diseases associated with ADRBK1 include allergic encephalomyelitis, and chronic pain. GO annotations related to this gene include phospholipid binding and G-protein coupled receptor kinase activity. An important paralog of this gene is AKT1.

UniProtKB/Swiss-Prot: ARBK1_HUMAN, P25098
Function: Specifically phosphorylates the agonist-occupied form of the beta-adrenergic and closely related
receptors, probably inducing a desensitization of them. Key regulator of LPAR1 signaling. Competes with RALA for
binding to LPAR1 thus affecting the signaling properties of the receptor. Desensitizes LPAR1 and LPAR2 in a
phosphorylation-independent manner

summary for ADRBK1 Gene:
Beta-adrenergic receptor kinase 1 (ADRBK1, also known as GRK2) phosphorylates the activated form of the beta
adrenergic receptor, thus acting as a form of negative feedback.

Gene Wiki entry for ADRBK1 (Beta adrenergic receptor kinase) Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence:
NC_000011.10  NC_018922.2  NT_167190.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the ADRBK1 gene promoter:
         Sp1   AP-2alpha isoform 3   AP-2alpha isoform 2   CREB   NF-AT2   deltaCREB   AP-2alpha isoform 4   AP-2alpha   AP-2alphaA   NF-AT1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidADRBK1 promoter sequence
   Search Chromatin IP Primers for ADRBK1

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat ADRBK1


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 11q13.1   Ensembl cytogenetic band:  11q13.2   HGNC cytogenetic band: 11q13

ADRBK1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
ADRBK1 gene location

GeneLoc information about chromosome 11         GeneLoc Exon Structure

GeneLoc location for GC11P067033:  view genomic region     (about GC identifiers)

Start:
67,033,881 bp from pter      End:
67,054,029 bp from pter
Size:
20,149 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
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UniProtKB/Swiss-Prot: ARBK1_HUMAN, P25098 (See protein sequence)
Recommended Name: Beta-adrenergic receptor kinase 1  
Size: 689 amino acids; 79574 Da
Subunit: Interacts with GIT1 (By similarity). Interacts with, and phosphorylates chemokine-stimulated CCR5.
Interacts with ARRB1. Interacts with LPAR1 and LPAR2. Interacts with RALA in response to LPAR1 activation. ADRBK1
and RALA mutually inhibit each other's binding to LPAR1
6 PDB 3D structures from and Proteopedia for ADRBK1:
1BAK (3D)        3CIK (3D)        3KRW (3D)        3KRX (3D)        3V5W (3D)        4MK0 (3D)    
Secondary accessions: B0ZBE1 Q13837 Q6GTT3

Explore the universe of human proteins at neXtProt for ADRBK1: NX_P25098

Explore proteomics data for ADRBK1 at MOPED

Post-translational modifications: 

  • Ubiquitination2 at Lys57, Lys62, Lys164, Lys230, Lys448, Lys644, Lys677
  • Modification sites at PhosphoSitePlus
  • Selected DME Specific Peptides for ADRBK1 (P25098) (see all 32)
     VVYRDLK  FFRSLDW  CSHPFSK  QSLLTME 


    See ADRBK1 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_001610.2  
    ENSEMBL proteins: 
     ENSP00000312262   ENSP00000434126  
    Reactome Protein details: P25098

    ADRBK1 Human Recombinant Protein Products:

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    Browse Proteins at Cloud-Clone Corp.

    ADRBK1 Antibody Products:

    EMD Millipore Mono- and Polyclonal Antibodies for the study of ADRBK1
    R&D Systems Antibodies for ADRBK1 (GRK2)
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    Browse ELISAs at Cloud-Clone Corp.
    Browse CLIAs at Cloud-Clone Corp.


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    PLEKH: Pleckstrin homology (PH) domain containing

    IUPHAR Guide to PHARMACOLOGY protein family classification: adrenergic, beta, receptor kinase 1
    G protein coupled receptor kinases
    BARK subfamily

    Selected InterPro protein domains (see all 11):
     IPR017441 Protein_kinase_ATP_BS
     IPR000239 GPCR_kinase
     IPR002290 Ser/Thr_dual-sp_kinase_dom
     IPR011009 Kinase-like_dom
     IPR001849 Pleckstrin_homology

    Graphical View of Domain Structure for InterPro Entry P25098

    ProtoNet protein and cluster: P25098

    4 Blocks protein domains:
    IPB000239 GPCR kinase signature
    IPB000342 Regulator of G-protein signalling (RGS) protein signature
    IPB000961 Protein kinase C-terminal domain
    IPB001849 Pleckstrin-like


    UniProtKB/Swiss-Prot: ARBK1_HUMAN, P25098
    Similarity: Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. GPRK subfamily
    Similarity: Contains 1 AGC-kinase C-terminal domain
    Similarity: Contains 1 PH domain
    Similarity: Contains 1 protein kinase domain
    Similarity: Contains 1 RGS domain


    ADRBK1 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: ARBK1_HUMAN, P25098
    Function: Specifically phosphorylates the agonist-occupied form of the beta-adrenergic and closely related
    receptors, probably inducing a desensitization of them. Key regulator of LPAR1 signaling. Competes with RALA for
    binding to LPAR1 thus affecting the signaling properties of the receptor. Desensitizes LPAR1 and LPAR2 in a
    phosphorylation-independent manner
    Catalytic activity: ATP + [beta-adrenergic receptor] = ADP + [beta-adrenergic receptor] phosphate

         Genatlas biochemistry entry for ADRBK1:
    beta-adrenergic receptor kinase 1,containing a CGG repeat in the 5'utr

         Enzyme Numbers (IUBMB): EC 2.7.11.151 2 EC 2.7.112

         Gene Ontology (GO): Selected molecular function terms (see all 10):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0004672protein kinase activity ISS--
    GO:0004674protein serine/threonine kinase activity ----
    GO:0004703G-protein coupled receptor kinase activity ISS--
    GO:0004713protein tyrosine kinase activity ----
    GO:0005515protein binding IPI17006543
         
    ADRBK1 for ontologies           About GeneDecksing


    Phenotypes:
         6 GenomeRNAi human phenotypes for ADRBK1:
     Decreased POU5F1-GFP protein e  Decreased Wnt reporter activit  Decreased substrate adherent c  Increased cell number in G2M,  
     Increased mitotic index  Small cells 

         11 MGI mutant phenotypes (inferred from 3 alleles(MGI details for Adrbk1):
     cardiovascular system  cellular  embryogenesis  growth/size/body  hematopoietic system 
     homeostasis/metabolism  immune system  integument  mortality/aging  muscle 
     normal 

    ADRBK1 for phenotypes           About GeneDecksing

    Animal Models:
         MGI mouse knock-outs for ADRBK1: Adrbk1tm1Mca Adrbk1tm1.1Gwd

       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for ADRBK1
       inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for ADRBK1

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for ADRBK1
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for ADRBK1

    miRNA
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    Selected qRT-PCR Assays for microRNAs that regulate ADRBK1 (see all 47):
    hsa-miR-15a hsa-miR-570 hsa-miR-424 hsa-miR-3613-3p hsa-miR-23a hsa-miR-296-5p hsa-miR-15b hsa-miR-761
    SwitchGear 3'UTR luciferase reporter plasmidADRBK1 3' UTR sequence
    Inhib. RNA
    Products:
        
    OriGene RNAi products in human, mouse, rat for ADRBK1
    Predesigned siRNA for gene silencing in human, mouse, rat ADRBK1

    Gene Editing
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    Clone
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    OriGene clones in human, mouse for ADRBK1 (see all 6)
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    GenScript: all cDNA clones in your preferred vector: ADRBK1 (NM_001619)
    Browse Sino Biological Human cDNA Clones
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    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat ADRBK1

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    In Situ Assay
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ADRBK1


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    cytosol4
    plasma membrane4
    nucleus2
    cytoskeleton1
    mitochondrion1

    Gene Ontology (GO): 4 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005737cytoplasm IDA17986524
    GO:0005829cytosol TAS--
    GO:0005886plasma membrane TAS--
    GO:0016020membrane ISS--

    ADRBK1 for ontologies           About GeneDecksing


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for ADRBK1 About   (see all 18)                                                                                              See pathways by source

    SuperPathSelected contained pathways About (see all per SuperPath)
    1ADP signalling through P2Y purinoceptor 12
    Development Angiotensin signaling via beta Arrestin0.39
    Beta-agonist/Beta-blocker Pathway, Pharmacodynamics0.34
    2Chemokine Signaling
    Chemokine signaling pathway0.33
    Chemokine Signaling0.33
    3Signaling by FGFR
    Signaling by FGFR0.91
    DAP12 interactions0.89
    Signaling by FGFR in disease0.91
    Signaling by PDGF0.87
    Downstream signaling of activated FGFR0.91
    Signaling by EGFR0.83
    Downstream signal transduction0.90
    Signaling by EGFR in Cancer0.82
    4Ca-dependent events
    DAG and IP3 signaling0.94
    PLCG1 events in ERBB2 signaling0.92
    EGFR interacts with phospholipase C-gamma0.94
    PLC beta mediated events0.67
    PLC-gamma1 signalling0.94
    G-protein mediated events0.65
    CaM pathway0.93
    Phospholipase C-mediated cascade0.59
    5Signaling by GPCR
    Signaling by GPCR0.90
    Signal Transduction0.58
    GPCR downstream signaling0.90

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    3 Downloadable PowerPoint Slides of GeneGlobe Pathway Central Maps for ADRBK1
        Chemokine Signaling
    Colorectal Cancer Metastasis
    G-AlphaQ Signaling

    1 Cell Signaling Technology (CST) Pathway for ADRBK1
        Neuroscience

    2 GeneGo (Thomson Reuters) Pathways for ADRBK1
        G-protein signaling G-Protein alpha-q signaling cascades
    Development Angiotensin signaling via beta-Arrestin

    4 BioSystems Pathways for ADRBK1
        Signaling events mediated by the Hedgehog family
    Signaling events mediated by HDAC Class II
    Thromboxane A2 receptor signaling
    CXCR4-mediated signaling events


    2 Reactome Pathways for ADRBK1
        G alpha (q) signalling events
    Calmodulin induced events

    2 PharmGKB Pathways for ADRBK1
        Beta-agonist/Beta-blocker Pathway, Pharmacodynamics
    Diuretics Pathway, Pharmacodynamics

    4 Kegg Pathways  (Kegg details for ADRBK1):
        Chemokine signaling pathway
    Endocytosis
    Glutamatergic synapse
    Morphine addiction


    ADRBK1 for pathways           About GeneDecksing

        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for ADRBK1
    Interactions:

        GeneGlobe Interaction Network for ADRBK1

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for ADRBK1 (P250981, 2, 3 ENSP000003122624) via UniProtKB, MINT, STRING, and/or I2D (see all 192)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    GIT1Q9Y2X71, 2, 3, ENSP000003783384EBI-3904795,EBI-466061 MINT-6608788 MINT-6608890 MINT-6608906 MINT-6608861 MINT-6608921 I2D: score=3 STRING: ENSP00000378338
    MDM2Q009871, 2, 3, ENSP000004172814EBI-3904795,EBI-389668 MINT-3376083 MINT-3376121 MINT-3376102 MINT-3376147 I2D: score=2 STRING: ENSP00000417281
    ENSG00000224774P678702, 3, ENSP000004156154MINT-8253000 I2D: score=2 STRING: ENSP00000415615
    ENSG00000232960P678702, 3, ENSP000003955464MINT-8253000 I2D: score=2 STRING: ENSP00000395546
    CSNK2BP678702, 3MINT-8253000 I2D: score=2 
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 21):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0002026regulation of the force of heart contraction ----
    GO:0002029desensitization of G-protein coupled receptor protein signaling pathway ISS--
    GO:0003108negative regulation of the force of heart contraction by chemical signal IMP15051637
    GO:0006468protein phosphorylation ----
    GO:0007165signal transduction TAS--

    ADRBK1 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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      Browse compounds at ApexBio 

    Compounds for ADRBK1 available from Tocris Bioscience    About this table
    CompoundAction CAS #
    GalleinInhibitor of betagamma signaling[2103-64-2]
    Suramin hexasodium saltNon-selective P2 antagonist[129-46-4]
    G-Protein antagonist peptideInhibits G protein activation by GPCRs[143675-79-0]
    8-Bromo-cGMP, sodium salt cGMP analog; activates PKG[51116-01-9]
    Pertussis Toxin Catalyzes ADP-ribosylation of Gi, Go and Gt [70323-44-3]

    3 HMDB Compounds for ADRBK1    About this table
    CompoundSynonyms CAS #PubMed Ids
    ADPadenosindiphosphorsaeure (see all 8)58-64-0--
    Adenosine triphosphate5'-(tetrahydrogen triphosphate) Adenosine (see all 24)56-65-5--
    ZincZinc (see all 2)7440-66-6--

    1 DrugBank Compound for ADRBK1    About this table
    CompoundSynonyms CAS #TypeActionsPubMed Ids
    Adenosine triphosphate5'-ATP (see all 8)56-65-5target--17139284 17016423

    Selected Novoseek inferred chemical compound relationships for ADRBK1 gene (see all 48)    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    etorphine 69 8 18395423 (2), 10999950 (1)
    threonine 58.9 6 18649053 (1), 15375164 (1), 11527375 (1), 19846537 (1) (see all 5)
    serine 52.4 17 15205374 (1), 14557268 (1), 18649053 (1), 15749741 (1) (see all 12)
    isoproterenol 48.7 21 16356165 (4), 16856836 (2), 16385076 (1), 18034461 (1) (see all 9)
    phosphoinositide 41 8 16885398 (2), 11259422 (2), 9211925 (1), 16807128 (1)
    alprenolol 40.3 1 15192083 (1)
    gf 109203x 39.6 2 12023974 (1), 15182196 (1)
    pip2 38.3 7 8798768 (3), 8798423 (3)
    forskolin 37.5 6 15155843 (1), 12372804 (1), 7559596 (1), 18451066 (1)
    tyrosine 35.6 50 16725308 (4), 10567420 (4), 12381737 (3), 15375164 (2) (see all 17)



    ADRBK1 for compounds           About GeneDecksing



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
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    REFSEQ mRNAs for ADRBK1 gene: 
    NM_001619.3  

    Unigene Cluster for ADRBK1:

    Adrenergic, beta, receptor kinase 1
    Hs.83636  [show with all ESTs]
    Unigene Representative Sequence: NM_001619
    14 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000308595(uc009yrn.1) ENST00000526285 ENST00000530291 ENST00000416281
    ENST00000529738 ENST00000533077 ENST00000534651 ENST00000532099 ENST00000526572
    ENST00000527176 ENST00000529815 ENST00000531390 ENST00000532611 ENST00000524899


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    Selected qRT-PCR Assays for microRNAs that regulate ADRBK1 (see all 47):
    hsa-miR-15a hsa-miR-570 hsa-miR-424 hsa-miR-3613-3p hsa-miR-23a hsa-miR-296-5p hsa-miR-15b hsa-miR-761
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    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat ADRBK1
    Primer
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    OriGene qPCR primer pairs and template standards for ADRBK1
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      QuantiTect SYBR Green Assays in human, mouse, rat ADRBK1
      QuantiFast Probe-based Assays in human, mouse, rat ADRBK1

    Additional mRNA sequence: 

    BC037963.1 BC090863.1 BC127253.1 M80776.1 X61157.1 

    21 DOTS entries:

    DT.95365634  DT.100789070  DT.101984390  DT.40117353  DT.101972063  DT.97860674  DT.100789069  DT.86856201 
    DT.444882  DT.92454573  DT.95205596  DT.92454587  DT.100038221  DT.95174908  DT.95365632  DT.120691856 
    DT.92454574  DT.92454607  DT.95365620  DT.100689804  DT.120691823 

    Selected AceView cDNA sequences (see all 486):

    BQ448312 BU621764 BE870013 BM554400 AW204462 CB269245 BI224925 BU621331 
    AA976569 CA417882 CD671377 BM769246 BG393363 BM762539 AK131506 BM854901 
    AW806763 BE764756 BM551059 CK429718 BE465461 CB122718 AI276436 AI571276 

    GeneLoc Exon Structure

    Selected Alternative Splicing Database (ASD) splice patterns (SP) for ADRBK1 (see all 11)    About this scheme

    ExUns: 1 ^ 2a · 2b ^ 3 ^ 4a · 4b ^ 5a · 5b ^ 6 ^ 7 ^ 8a · 8b ^ 9a · 9b ^ 10 ^ 11a · 11b ^ 12a · 12b ^ 13 ^ 14a · 14b ^ 15 ^ 16 ^ 17a · 17b ·
    SP1:        -                                                     -                                                                                         -   
    SP2:                                                                                                                                            -               
    SP3:                                                                                                        -     -                                         -   
    SP4:                                                                                                                                                            
    SP5:                                                                                                                                                            

    ExUns: 17c ^ 18a · 18b · 18c · 18d ^ 19a · 19b · 19c ^ 20a · 20b ^ 21a · 21b ^ 22a · 22b
    SP1:  -     -                                                                           
    SP2:                                                                                    
    SP3:  -     -                                                                           
    SP4:                                                                                    
    SP5:                                                                                    


    ECgene alternative splicing isoforms for ADRBK1

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

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    ADRBK1 expression in normal human tissues (normalized intensities)      ADRBK1 embryonic expression: see
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: CCCCCTCGTG
    ADRBK1 Expression
    About this image


    ADRBK1 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 13) fully expand
     
     Brain (Nervous System)    fully expand to see all 2 entries
             Cerebral Cortex
     
     Thymus (Hematopoietic System)
             Double Negative 2 Thymocytes Thymus
     
     Bone (Muscoskeletal System)
             Bone Marrow
     
     Trophoblast (Extraembryonic Tissues)
             Trophoblast Cells Trophoblast
     
     Ovary (Reproductive System)
             Oviduct
    ADRBK1 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    ADRBK1 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.83636

    UniProtKB/Swiss-Prot: ARBK1_HUMAN, P25098
    Tissue specificity: Expressed in peripheral blood leukocytes

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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of animals.

    Orthologs for ADRBK1 gene from Selected species (see all 12)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Adrbk11 , 5 adrenergic receptor kinase, beta 11, 5 89.85(n)1
    98.76(a)1
      19 (3.98 cM)5
    1103551  NM_130863.11  NP_570933.11 
     42860015 
    chicken
    (Gallus gallus)
    Aves ADRBK11 adrenergic, beta, receptor kinase 1 85.42(n)
    92.15(a)
      426000  NM_001031353.1  NP_001026524.1 
    lizard
    (Anolis carolinensis)
    Reptilia ADRBK16
    adrenergic, beta, receptor kinase 1
    92(a)
    1 ↔ 1
    1(92749325-92781716)
    zebrafish
    (Danio rerio)
    Actinopterygii adrbk26
    adrenergic, beta, receptor kinase 2
    85(a)
    1 → many
    10(45780762-45926621) ENSDARG00000013007
    fruit fly
    (Drosophila melanogaster)
    Insecta Gprk13 protein amino acid phosphorylation
    protein serine/threonine more
    66(a)     --
    worm
    (Caenorhabditis elegans)
    Secernentea W02B3.23 G-protein coupled receptor 63(a)   III(676123-680041)   --


    ENSEMBL Gene Tree for ADRBK1 (if available)
    TreeFam Gene Tree for ADRBK1 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for ADRBK1 gene
    AKT12  GRK72  RPS6KB12  GRK12  SGK32  GRK42  GRK62  C8orf44-SGK32  
    SGK22  ADRBK22  AKT32  SGK12  RPS6KB22  GRK52  AKT22  
    Selected SIMAP similar genes for ADRBK1 using alignment to 2 protein entries:     ARBK1_HUMAN (see all proteins) (see all similar genes):
    ADRBK2    RPS6KA2    STK32A    PRKCH    STK11    RPS6KA3
    CAMK1    DKFZp564L2416    MAP4K5    SGK2    PRKACB    SGK3
    GRK5    KIN27    PRKACA    STK32B    AKT3    PRKAA1

    ADRBK1 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for ADRBK1 (see all 44)    About this table    
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 11 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    VAR_0403794
    A colorectal adenocarcinoma sample4--see VAR_0403792 R Q mis40--------
    rs1385521561,2
    C--67031922(+) AAGACC/TACCTG 1 -- us2k10--------
    rs127918531,2
    C,F,H--67031968(+) CCACGG/AAGGAA 1 -- us2k124Minor allele frequency- A:0.09NS EA NA WA 3326
    rs617584931,2
    C,F--67031985(+) CAGAAG/TGGCTT 1 -- us2k13Minor allele frequency- T:0.02NS CSA WA 681
    rs617584941,2
    C,F--67032048(+) GTGGGG/TAAACT 1 -- us2k11Minor allele frequency- T:0.01NS 562
    rs1171413631,2
    F--67032241(+) TGGGTG/ACCAAG 1 -- us2k11Minor allele frequency- A:0.01EA 120
    rs580644121,2
    C--67032353(+) TTCACG/AGAGAT 1 -- us2k12Minor allele frequency- A:0.03WA 120
    rs1882386641,2
    --67032603(+) AAAGGA/GTGCTG 1 -- us2k10--------
    rs1496087291,2
    C--67032950(+) GTTGGC/GGGGTG 1 -- us2k10--------
    rs617584971,2
    F--67032984(+) CCTGAG/CTGGGC 1 -- us2k11Minor allele frequency- C:0.00NS 532

    HapMap Linkage Disequilibrium report for ADRBK1 (67033881 - 67054029 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 7 variations for ADRBK1:    About this table    
    Variant IDTypeSubtypePubMed ID
    nsv897800CNV Loss21882294
    nsv897796CNV Loss21882294
    nsv897797CNV Loss21882294
    nsv897802CNV Loss21882294
    nsv897801CNV Loss21882294
    nsv468603CNV Loss19166990
    dgv1192n71CNV Loss21882294

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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 109635    OMIM disorders: --

    Selected diseases for ADRBK1 (see all 34):    About MalaCards
    allergic encephalomyelitis    chronic pain    portal hypertension    schizoaffective disorder
    encephalomyelitis    major depressive disorder    dilated cardiomyopathy    essential hypertension
    hypertension    anorexia nervosa    pertussis    alzheimer's disease
    bipolar disorder    myocardial infarction    sepsis    insulin resistance
    acute myocardial infarction    parkinson's disease    multiple sclerosis    ischemia


    ADRBK1 for disorders           About GeneDecksing


    Congresses - knowledge worth sharing:
    Alzheimer's & Parkinson's Diseases Congress (ADPD) 18 - 22 March 2015

    Selected Novoseek inferred disease relationships for ADRBK1 gene (see all 23)    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    heart failure 50.2 54 17322894 (4), 20501412 (3), 16678578 (3), 11331748 (3) (see all 26)
    cardiac function impaired 37.8 3 15242731 (1), 10441103 (1)
    cardiomyopathy 18.5 1 16412044 (1)
    cardiac hypertrophy 14 4 18797934 (1), 9931137 (1), 19229505 (1)
    heart failure congestive 11.3 4 20128603 (1)
    hypertrophy 8.55 2 10790351 (1), 15097244 (1), 17573483 (1)
    necrosis 5.12 2 10790351 (1), 16385076 (1)
    cancer 0.534 1 18451066 (1)
    tumors 0.41 4 14665717 (1), 10790351 (1), 12869546 (1), 16385076 (1)
    hypertension portal 0 1 16530538 (1)

    Genetic Association Database (GAD): ADRBK1
    Human Genome Epidemiology (HuGE) Navigator: ADRBK1 (8 documents)

    Export disorders for ADRBK1 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for ADRBK1 gene, integrated from 10 sources (see all 439):
    (articles sorted by number of sources associating them with ADRBK1)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. cDNA cloning and chromosomal localization of the human beta- adrenergic receptor kinase. (PubMed id 2037065)1, 2, 3 Benovic J.L....Lefkowitz R.J. (FEBS Lett. 1991)
    2. Monocyte chemoattractant protein-1-induced CCR2B receptor desensitization mediated by the G protein-coupled receptor kinase 2. (PubMed id 9501202)1, 2, 9 Aragay A.M.... Mayor F. Jr. (Proc. Natl. Acad. Sci. U.S.A. 1998)
    3. A GRK5 polymorphism that inhibits beta-adrenergic receptor signaling is protective in heart failure. (PubMed id 18425130)1, 4, 9 Liggett S.B.... Dorn G.W. II (Nat. Med. 2008)
    4. Differential effects of CC chemokines on CC chemokine receptor 5 (CCR5) phosphorylation and identification of phosphorylation sites on the CCR5 carboxyl terminus. (PubMed id 10085131)1, 2, 9 Oppermann M.... Olbrich H. (J. Biol. Chem. 1999)
    5. The solution structure and dynamics of the pleckstrin homology domain of G protein-coupled receptor kinase 2 (beta-adrenergic receptor kinase 1). A binding partner of Gbetagamma subunits. (PubMed id 9446593)1, 2, 9 Fushman D....Cowburn D. (J. Biol. Chem. 1998)
    6. Association study of 182 candidate genes in anorexia nervosa. (PubMed id 20468064)1, 4 Pinheiro A.P....Woodside D.B. (Am. J. Med. Genet. B Neuropsychiatr. Genet. 2010)
    7. Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study. (PubMed id 20628086)1, 4 Bailey S.D....Anand S. (Diabetes Care 2010)
    8. Dual regulation of lysophosphatidic acid (LPA1) receptor signalling by Ral and GRK. (PubMed id 19306925)1, 2 Aziziyeh A.I.... Bhattacharya M. (Cell. Signal. 2009)
    9. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    10. Structure of the human gene encoding the beta-adrenergic receptor kinase. (PubMed id 8195124)1, 2 Penn R.B. and Benovic J.L. (J. Biol. Chem. 1994)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section

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    Entrez Gene: 156 HGNC: 289 AceView: ADRBK1 Ensembl:ENSG00000173020 euGenes: HUgn156
    ECgene: ADRBK1 Kegg: 156 H-InvDB: ADRBK1

    (According to HUGE)
    About This Section

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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
    About This Section

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    NameDescription
    PharmGKB entry for ADRBK1 Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for ADRBK1 Genetics and Cytogenetics in Oncology and Haematology
    Wikipedia http://en.wikipedia.org/wiki/Beta_Adrenergic_Receptor_Kinase

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for ADRBK1 gene:
    Search GeneIP for patents involving ADRBK1

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript, and ESI BIO, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
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