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ADRBK1 Gene

protein-coding GIFtS: 68

GC11P066790

adrenergic, beta, receptor kinase 1
Symbol approved by the HUGO Gene Nomenclature Committee (HGNC) database

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc , and/or ⁷Ensembl, ⁸miRBase)
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Aliases
BARK ^³
BARK1 ^¹, ², ³
BETA-ARK1 ^²
Beta-ARK-1 ^³
EC 2.7.11.15 ^³
FLJ16718 ^²
GRK2 ^¹, ², ³

Descriptions
G-protein coupled receptor kinase 2 ^³
adrenergic, beta, receptor kinase 1 ^²
beta-adrenergic receptor kinase 1 ^²

External Ids
HGNC: 289¹
Entrez Gene: 156²
UniProtKB: P25098³
Ensembl: ENSG00000173020⁷

Search outside databases for aliases for ADRBK1 gene

Previous GC identifers: GC11P069548 GC11M068669 GC11P067284 GC11P066809

(According to Entrez Gene, Wikipedia's Gene Wiki,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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EntrezGene summary for ADRBK1:

The product of this gene phosphorylates the beta-2-adrenergic receptor and appears to mediate

agonist-specific desensitization observed at high agonist concentrations. This protein is an

ubiquitous cytosolic enzyme that specifically phosphorylates the activated form of the

beta-adrenergic and related G-protein-coupled receptors. Abnormal coupling of beta-adrenergic

receptor to G protein is involved in the pathogenesis of the failing heart. [provided by RefSeq]

UniProtKB/Swiss-Prot: ARBK1_HUMAN, P25098

Function: Specifically phosphorylates the agonist-occupied form of the beta-adrenergic and closely

related receptors, probably inducing a desensitization of them

Gene Wiki entry for ADRBK1 (Beta_adrenergic_receptor_kinase)

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 36),
and/or miRBase,
Genomic Views according to UCSC and Ensembl, Transcription factor binding sites according to SABiosciences)
About This Section

Genomic View:

UCSC Golden Path with GeneCards custom track

Transcription factor binding sites upstream to the ADRBK1 gene

Entrez Gene cytogenetic band: 11q13.1 Ensembl cytogenetic band: 11q13.1 HGNC cytogenetic band: 11q13

ADRBK1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)

GeneLoc gene densities for chromosome 11 GeneLoc Exon Structure

GeneLoc location for GC11P066790: (about GC identifiers)

Start:	66,790,481 bp from pter
End:	66,810,605 bp from pter
Size:	20,125 bases
Orientation:	plus strand

RefSeq DNA sequence:

NC_000011.8 NT_033903.7

(According to ¹UniProtKB, and/or Ensembl, Phosphorylation sites according to ²Phosphosite, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Enzo Life Sciences, Abnova, OriGene and/or, Abcam,
Biochemical Assays by Invitrogen, Millipore, R&D Systems, Cell Signaling Technology, and/or Enzo Life Sciences, Ontologies according to Gene Ontology Consortium 01 Apr 2009 and Entrez Gene, Antibodies by Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Cell Signaling Technology, Abcam, Abnova, and/or Novus Biologicals)
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UniProtKB/Swiss-Prot: ARBK1_HUMAN, P25098 (See protein sequence)

Recommended Name: Beta-adrenergic receptor kinase 1

Size: 689 amino acids; 79574 Da

Subunit: Interacts with GIT1 (By similarity). Interacts with, and phosphorylates

chemokine-stimulated CCR5

PDB structure from and Proteopedia :

1BAK (3D)

3CIK (3D)

Secondary accessions: B0ZBE1 Q13837 Q6GTT3

Post-translational modifications:

View phosphorylation sites using PhosphoSite²

REFSEQ proteins: NP_001610.2

ENSEMBL proteins:

ENSP00000312262

Human Recombinant Proteins

	Invitrogen human recombinant proteins for ADRBK1
	Browse Purified and Recombinant Proteins at Millipore
	Browse Human Recombinant Proteins at Sigma-Aldrich
	Browse R&D Systems for human recombinant proteins
	Browse recombinant and purified proteins available from Enzo Life Sciences
	Recombinant Proteins from Abcam (GRK2, GRK2 + 3)
	Human Recombinant Proteins from Abnova (ADRBK1)

Browse Origene for full length recombinant human proteins expressed in human HEK293 cells

3 Gene Ontology (GO) cellular component terms (links to tree view):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005625	soluble fraction	TAS	1339451
GO:0005737	cytoplasm	IDA	17986524
GO:0016020	membrane	IEA	--

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Antibodies for ADRBK1:

	Invitrogen Antibodies for ADRBK1
	Millipore Mono- and Polyclonal Antibodies for the study of ADRBK1
	Sigma-Aldrich Antibodies for ADRBK1
	R&D Systems Antibodies for ADRBK1 (GRK2)
	Cell Signaling Technology (CST) Antibodies for ADRBK1 (BARK1/GRK2)
	Antibodies from Abcam (GRK2, GRK2 + 3), each with their Abpromise^SM
	Monoclonal and Polyclonal Antibodies from Abnova (ADRBK1)
	Novus Biologicals Antibodies for ADRBK1

Assays for ADRBK1:

	Invitrogen Assays for ADRBK1
	Browse Kits and Assays available from Millipore
	Browse R&D Systems for biochemical assays
	Browse biochemical assays available from Enzo Life Sciences

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

Graphical View of Domain Structure for InterPro Entry P25098

ProtoNet protein and cluster: P25098

4 Blocks protein families:

IPB000239 GPCR kinase signature

IPB000342 Regulator of G-protein signalling (RGS) protein signature

IPB000961 Protein kinase C-terminal domain

IPB001849 Pleckstrin-like

UniProtKB/Swiss-Prot: ARBK1_HUMAN, P25098

Similarity: Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. GPRK

subfamily

Similarity: Contains 1 AGC-kinase C-terminal domain

Similarity: Contains 1 PH domain

Similarity: Contains 1 protein kinase domain

Similarity: Contains 1 RGS domain

(According to MGI Jun 06 2009, UniProtKB, IUBMB,and/or Genatlas,
shRNA from OriGene, Sigma-Aldrich, RNAi from Sigma-Aldrich,
RNAi Products, Clones, and Q-PCR Products from Invitrogen, Millipore, OriGene, and/or Abnova, siRNAs from Applied Biosystems, SYBR primers from OriGene, Cell-based Assays from Millipore, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
About This Section

Inhib. RNA:		Invitrogen RNAi Products for gene knock-down (ADRBK1)
		Browse for Gene Knock-down Tools from Millipore
		Abnova Chimera RNAi Products for Gene knock-down (ADRBK1)

OriGene 29mer shRNA kit in GFP-retroviral vector: NM_001619

Applied Biosystems Silencer® siRNAs for ADRBK1

Sigma-Aldrich siRNA and siRNA Panels for ADRBK1

Sigma-Aldrich shRNA Panels and shRNA for ADRBK1

Explore Sigma-Aldrich super-pooled esiRNAs

Clones:		Invitrogen Clones for ADRBK1
		Browse Clones for the Expression of Recombinant Proteins Available from Millipore

OriGene GFP tagged cDNA clone in CMV expression vector: NM_001619
Myc/DDK tagged cDNA clone in CMV expression vector: NM_001619
untagged cDNA clone in CMV expression vector: NM_001619

Primers:

Browse Quantitative PCR Central at Invitrogen for Q-PCR LUX™ Primers

OriGene genome-wide validated SYBR primer pairs: NM_001619

UniProtKB/Swiss-Prot: ARBK1_HUMAN, P25098

Function: Specifically phosphorylates the agonist-occupied form of the beta-adrenergic and closely

related receptors, probably inducing a desensitization of them

Catalytic activity: ATP + [beta-adrenergic receptor] = ADP + [beta-adrenergic receptor] phosphate

Enzyme Number (IUBMB): EC 2.7.11.15

Genatlas biochemistry entry for ADRBK1:

beta-adrenergic receptor kinase 1,containing a CGG repeat in the 5'utr

9 MGI mutant phenotypes (inferred from 3 alleles) (MGI details for Adrbk1):

	embryogenesis	growth/size	homeostasis/metabolism	lethality-prenatal/perinatal
life span-post-weaning/aging	muscle	normal	skin/coat/nails

5/7 Gene Ontology (GO) molecular function terms (links to tree view) (see all 7 ):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0000166	nucleotide binding	IEA	--
GO:0004703	G-protein coupled receptor kinase activity	IEA	--
GO:0004871	signal transducer activity	IEA	--
GO:0005515	protein binding	IEA	--
GO:0005524	ATP binding	IEA	--

About this table

(Pathways according to Invitrogen (maps by GeneGo), Millipore, Cell Signaling Technology, Sigma-Aldrich, KEGG and/or UniProtKB,
Sets of similar genes according to GeneDecks, Proteins Network according to SABiosciences, Interactions according to ¹UniProtKB, ²MINT, and/or ³STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
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4 Sigma-Aldrich "Your Favorite Gene" Pathways for ADRBK1 (Your Favorite Gene powered by Ingenuity)

Cardiac &beta
Sonic Hedgehog Signaling
cAMP-mediated Signaling
G-Protein Coupled Receptor Signaling

GeneDecks ADRBK1 for the pathways selected above

About GeneDecksing

Gene Network Central^TM Interacting Genes and Proteins Network for ADRBK1

5/87 Interacting proteins for ADRBK1 (P25098² ENSP00000312262³) via UniProtKB, MINT, and/or STRING (see all 87 )

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
GIT1	Q9Y2X7², ENSP00000225394³	MINT-6608788 MINT-6608890 MINT-6608906 MINT-6608861 MINT-6608921 STRING (score=.989)
EGFR	P00533², ENSP00000275493³	MINT-51490 MINT-51492 MINT-51491 STRING (score=.958)
MDM2	Q00987²	MINT-3376083 MINT-3376121 MINT-3376102 MINT-3376147
RPS27A	P62988²	MINT-3376233 MINT-3376168 MINT-3376202
RPS27AP11	P62988²	MINT-3376233 MINT-3376168 MINT-3376202

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5/11 Gene Ontology (GO) biological process terms (links to tree view) (see all 11 ):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0002026	regulation of the force of heart contraction	IEA	--
GO:0002029	desensitization of G-protein coupled receptor protein signaling pathway	IEA	--
GO:0003108	negative regulation of the force of heart contraction by chemical signal	IMP	15051637
GO:0007165	signal transduction	IEA	--
GO:0007213	muscarinic acetylcholine receptor signaling pathway	ISS	--

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(Chemical Compounds according to UniProtKB, Enzo Life Sciences, Sigma-Aldrich, Tocris Bioscience, and/or Novoseek and Drugs according to Enzo Life Sciences and/or PharmGKB)
About This Section

Browse drugs & compounds from Enzo Life Sciences

Browse Small Molecules at Sigma-Aldrich

Browse Tocris compounds for ADRBK1
10/24 Novoseek chemical compound relationships for ADRBK1 gene (see all 24 )

Compound	Score	Articles	PubMed IDs for Articles with Shared Sentences (# sentences)
threonine	56.83	5	18649053 (1), 15375164 (1), 11527375 (1), 16121194 (1)
phosphoinositide	40.69	8	16885398 (2), 11259422 (2), 9211925 (1), 16807128 (1)
pip2	39.83	7	8798768 (3), 8798423 (3)
forskolin	39.11	6	15155843 (1), 12372804 (1), 7559596 (1), 18451066 (1)
tyrosine	36.91	48	16725308 (4), 10567420 (4), 12381737 (3), 15375164 (2) (see all 16)
tarc	35.44	1	15749741 (1)
damgo	34.28	7	12750434 (3), 11299306 (2), 16682505 (1)
inositol 1,4,5 trisphosphate	26.93	3	10342843 (2)
calcium	22.29	20	18388243 (3), 9501202 (2), 17971124 (2), 14761932 (1) (see all 9)
phorbol	20.10	1	11042191 (1)

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1 PharmGKB drug compound relationship for ADRBK1 gene

Drug compound	PharmGKB Relations	PubMed IDs for articles supporting these relationships
Beta adrenergic antagonists	FA	11900882 14499340

About this table

(GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 219 Homo sapiens; Jun 2 2009) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView,
non coding RNAs according to RNAdb,
ESTs according to GeneTide,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from Invitrogen, Millipore, and/or Abnova,
siRNAs from Applied Biosystems, Sigma-Aldrich,
shRNA from Sigma-Aldrich, OriGene,
Tagged/untagged cDNA clones from OriGene,
Expression Assays from Applied Biosystems)
About This Section

Inhib. RNA:		Invitrogen RNAi Products for gene knock-down (ADRBK1)
		Browse for Gene Knock-down Tools from Millipore
		Abnova Chimera RNAi Products for Gene knock-down (ADRBK1)

OriGene 29mer shRNA kit in GFP-retroviral vector: NM_001619

Sigma-Aldrich siRNA and siRNA Panels for ADRBK1

Sigma-Aldrich shRNA Panels and shRNA for ADRBK1

Explore Sigma-Aldrich super-pooled esiRNAs

Applied Biosystems Silencer® siRNAs:

NM_001619

REFSEQ mRNAs for ADRBK1 gene:

NM_001619.3

Applied Biosystems TaqMan ® Gene Expression Assays:

NM_001619

              OriGene GFP tagged cDNA clone in CMV expression vector: NM_001619
                                 Myc/DDK tagged cDNA clone in CMV expression vector: NM_001619
                                 untagged cDNA clone in CMV expression vector: NM_001619

Additional cDNA sequence:

BC037963.1 BC090863.1 BC127253.1 CR616194.1 CR620940.1 M80776.1 X61157.1

20 DOTS entries:

DT.95365634 DT.100789070 DT.101984390 DT.40117353 DT.101972063 DT.97860674 DT.444882 DT.100789069

DT.86856201 DT.92454573 DT.95205596 DT.92454587 DT.100038221 DT.95174908 DT.95365632 DT.120691856

DT.92454574 DT.92454607 DT.95365620 DT.120691823

24/486 AceView cDNA sequences (see all 486 ):

BE392195 BM463298 BQ223251 BU191678 BM561607 BE140522 BM551059 AW806794

CD672416 AL135126 AI916030 CK430495 BQ689379 AW806763 BE764756 BI000372

AW440903 BG177376 AA504173 AK131506 BE396794 BE396870 BE712989 CD671377

highest scoring ESTs for ADRBK1:

AA284038 AA316287 AA411038 AA459417 AA459643 AA489013 AA489106 AA504173 AA504174 AA573882

Unigene Cluster for ADRBK1:

Adrenergic, beta, receptor kinase 1

Hs.83636 [show with all ESTs]

Unigene Representative Sequence: NM_001619

GeneLoc Exon Structure

5/11 Alternative Splicing Database (ASD) splice patterns (SP) for ADRBK1 (see all 11 )

ExUns:	1	^	2a	·	2b	^	3	^	4a	·	4b	^	5a	·	5b	^	6	^	7	^	8a	·	8b	^	9a	·	9b	^	10	^	11a	·	11b	^	12a	·	12b	^	13	^	14a	·	14b	^	15	^	16	^	17a	·	17b	·
SP1:			-																		-																														-
SP2:																																															-
SP3:																																			-		-														-
SP4:
SP5:

ExUns:	17c	^	18a	·	18b	·	18c	·	18d	^	19a	·	19b	·	19c	^	20a	·	20b	^	21a	·	21b	^	22a	·	22b
SP1:	-		-
SP2:
SP3:	-		-
SP4:
SP5:

About this scheme

ECgene alternative splicing isoforms for ADRBK1

1 Ensembl transcript including schematic representation:

ENST00000308595

(Experimental results according to ¹GeneNote and GNF BioGPS,
probe sets-to-genes annotations according to ²GeneAnnot , ³GeneTide , Sets of similar genes according to GeneDecks, Electronic Northern calculations according to data from UniGene (Build 219 Homo sapiens), SAGE tags according to CGAP, plus additional links to SOURCE, and/or GNF BioGPS, and/or EXPOLDB, and/or UniProtKB,
Expression Assays from Applied Biosystems )
About This Section

ADRBK1 expression in normal and diseased human tissues

Applied Biosystems TaqMan ® Gene Expression Assays for ADRBK1

¹ / ² / ³

5 probe-sets matching ADRBK1 gene

Affymetrix probe-set	Array	# genes	Sensitivity	Specificity	Correlation	Length	Gb_Accession	Consensus	Uniqueness	Score	Rank
Affymetrix probe-set	Array	GeneAnnot data			GeneNote data		GeneTide data
38447_at*²^{, 3}	U133-A	1	--	--	1.00	1.00	U08438	0.20	1.00	0.72	1
201401_s_at²^{, 3}	U133-A	1	1.00	1.00	--	--	M80776	0.80	1.00	0.91	1
38447_at*²^{, 3}	U133-A	NULL	0.00	0.00	--	--	U08438	0.20	1.00	0.72	1
201401_s_at²	U133Plus2	1	1.00	1.00	--	--	--	--	--	--	--
38447_at*²	U133Plus2	NULL	0.00	0.00	--	--	--	--	--	--	--

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Data from

(Publications) and GNF BioGPS
About these images
About these images

CGAP SAGE TAG: CCCCCTCGTG

SOURCE GeneReport for Unigene cluster: Hs.83636
Expression variation in blood from EXPOLDB for ADRBK1
UniProtKB/Swiss-Prot: ARBK1_HUMAN, P25098
Tissue specificity: Expressed in peripheral blood leukocytes

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD and/or ⁵MGI Jun 06 2009, with possible further links to Flybase and/or WormBase, Gene Trees according to Ensembl)
About This Section

Orthologs for ADRBK1 gene from 5/8 species (see all 8 )

Organism	Gene	Locus	Description	Human Similarity	NCBI accessions
dog (Canis familiaris)	ADRBK1¹	--	adrenergic, beta, receptor kinase 1	92.74(n) 98.55(a)	483701 XM_846992.1 XP_852085.1
chimpanzee (Pan troglodytes)	ADRBK1¹	--	adrenergic, beta, receptor kinase 1	99.6(n) 100(a)	451363 XM_508589.2 XP_508589.2
cow (Bos taurus)	ADRBK1¹	--	adrenergic, beta, receptor kinase 1	93.03(n) 98.4(a)	282682 NM_174710.2 NP_777135.1
rat (Rattus norvegicus)	Adrbk1¹	--	adrenergic, beta, receptor kinase 1	90.32(n) 98.4(a)	25238 NM_012776.1 NP_036908.1
mouse (Mus musculus)	Adrbk1^{1, 5}	19 (3.00 cM)⁵	adrenergic receptor kinase, beta 1^{1, 5}	89.85(n)¹ 98.76(a)¹	110355¹ NM_130863.1¹ NP_570933.1¹ AF333028⁵ AI451468⁵ (see all 16)

About this table Species with no ortholog for ADRBK1

ENSEMBL Gene Tree for ADRBK1

(Paralogs according to ¹HomoloGene
and ²Ensembl, Pseudogenes according to ³Pseudogene.org)
About This Section

Paralogs for ADRBK1 gene

GRK7² ADRBK2²

(According to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, and UniProtKB, Linkage Disequilibrium by HapMap, Genotyping Reagents from Applied Biosystems)
About This Section

10/165 NCBI SNPs in ADRBK1 are shown (see all 165 )
(Click for Applied Biosystems TaqMan ® Genotyping Assay) (see all 52)

AB	SNP ID	Valid	Chr 11 pos	Sequence	Recs	AA Chg	Type	More	Recs	Allele freq	Pop	Total sample	More
AB	Genomic Data				Transcription Data				Allele Frequencies
				--	--	--		--	--				--
	rs12791853^1,2	C,F,H	66788544(+)	`CCACGG/AAGGAA`	1	--	ng5¹		8		EU EA WA	838
	rs11605263^1,2	C,F,H	66789652(+)	`GGTCCC/TAGGTT`	1	--	ng5¹		4		EU EA WA	420
--	rs10791901^1,2	C	66789609(+)	`GGATCA/GGGGAT`	1	--	ng5¹		0	--	--	--	--
--	rs1009943^1,2	C	66805215(+)	`GGAAGG/CCTGAC`	1	P/A	mis¹ ese³		2		MN EA	356
	rs1051180^1,2	C	66807212(+)	`ACTACG/ACTCCC`	1	H/R	mis¹ ese³		2		MN EA	356
--	rs1009944^1,2	C	66805216(+)	`GAAGGC/GTGACA`	1	A/G	mis¹ ese³		2		MN EA	356
--	rs4468356^1,2	C	66809546(+)	`ATTTTA/TATTAT`	1	--	ut3¹		0	--	--	--	--
	rs1573538^1,2	C	66807799(-)	`ATCTGC/TCAGAC`	1	W/X	non¹ ese³		1		EA	172
	rs1977983^1,2	C	66807795(-)	`GTCAGA/TCCAGG`	1	D/V	mis¹ ese³		1		EA	172
	rs12286664^1,2	H	66789725(+)	`AGTCCG/ATGTCC`	1	--	ng5¹		3		EU EA	298

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HapMap Linkage Disequilibrium images for ADRBK1 (up to first 250kb)

(in which this Gene is Involved, According to OMIM, UniProtKB, Novoseek, PharmGKB, Genatlas, GeneTests, Blood group antigen gene mutations by BGMUT, HGMD, GAD, HuGE Navigator, BCGD, and/or TGDB.)
About This Section

OMIM: 109635

10/22 Novoseek disease relationships for ADRBK1 gene (see all 22 )

Disease	Score	Articles	PubMed IDs for Articles with Shared Sentences (# sentences)
heart failure	47.42	43	17322894 (4), 16678578 (3), 11331748 (3), 8293560 (2) (see all 22)
cardiac function impaired	39.99	3	15242731 (1), 10441103 (1)
cardiomyopathy	16.98	1	16412044 (1)
cardiac hypertrophy	16.64	4	18797934 (1), 9931137 (1), 19229505 (1)
hypertrophy	11.20	2	10790351 (1), 15097244 (1), 17573483 (1)
necrosis	3.65	2	10790351 (1), 16385076 (1)
metastasis	3.44	2	17146477 (1)
cancer	0.34	1	18451066 (1)
tumors	0.29	4	14665717 (1), 10790351 (1), 12869546 (1), 16385076 (1)
myocardial infarction	0.00	3	10779554 (1), 19229505 (1)

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2 PharmGKB disease relationships for ADRBK1 gene

Disease	PharmGKB Relations	PubMed IDs for articles supporting these relationships
Heart Failure, Congestive	FA	14499340
Hypertension	FA	14499340

About this table

Human Genome Epidemiology Navigator: ADRBK1 (2 documents)

(Possibly Related Articles in Doctor's Guide)
About This Section

(in PubMed. Associations of this gene to articles via ¹Novoseek, ²HGNC, ³Entrez Gene, ⁴UniProtKB/Swiss-Prot, ⁵UniProtKB/TrEMBL, ⁶GAD, and/or ⁷PharmGKB)
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10/337 PubMed articles for ADRBK1 gene (see all 337 ):

cDNA cloning and chromosomal localization of the human beta- adrenergic receptor kinase. (PubMed id 2037065)^{2, 3, 4} Benovic J.L....Lefkowitz R.J. (1991)
Differential effects of CC chemokines on CC chemokine receptor 5 (CCR5) phosphorylation and identification of phosphorylation sites on the CCR5 carboxyl terminus. (PubMed id 10085131)^{1, 3, 4} Oppermann M....Olbrich H. (1999)
The solution structure and dynamics of the pleckstrin homology domain of G protein-coupled receptor kinase 2 (beta-adrenergic receptor kinase 1). A binding partner of Gbetagamma subunits. (PubMed id 9446593)^{1, 3, 4} Fushman D....Cowburn D. (1998)
The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)^{3, 4} Gerhard D.S....Malek J. (2004)
Structure of the human gene encoding the beta-adrenergic receptor kinase. (PubMed id 8195124)^{3, 4} Penn R.B. and Benovic J.L. (1994)
High expression of beta-adrenergic receptor kinase in human peripheral blood leukocytes. Isoproterenol and platelet activating factor can induce kinase translocation. (PubMed id 1339451)^{3, 4} Chuang T.T.... de Blasi A. (1992)
Agonist-induced formation of opioid receptor-G protein-coupled receptor kinase (GRK)-G beta gamma complex on membrane is required for GRK2 function in vivo. (PubMed id 12750365)^{1, 3} Li J....Ma L. (2003)
Agonist-dependent modulation of G protein-coupled receptor kinase 2 by mitogen-activated protein kinases. (PubMed id 10727525)^{1, 3} Elorza A....Mayor F. (2000)
Phosphorylation of phosducin and phosducin-like protein by G protein-coupled receptor kinase 2. (PubMed id 10884381)^{1, 3} Ruiz-Gomez A....Mayor F. (2000)
Tyrosine phosphorylation of G-protein-coupled-receptor kinase 2 (GRK2) by c-Src modulates its interaction with Galphaq. (PubMed id 16725308)^{1, 3} Mariggio S....Ribas C. (2006)

(in PubMed, OMIM, and NCBI Bookshelf)
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		AND	OR
Aliases
Free Text

Query String		PubMed OMIM NCBI Bookshelf
	(Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, and/or H-InvDB)
About This Section

Entrez Gene: 156	HGNC: 289	AceView: ADRBK1	Ensembl:ENSG00000173020	euGenes: HUgn156
ECgene: ADRBK1	H-InvDB: ADRBK1

(According to HUGE)
About This Section

(According to ATLAS, HORDE, IMGT, MTDB, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section

Name	Description
ATLAS Chromosomes in Cancer entry for ADRBK1	Genetics and Cytogenetics in Oncology and Haematology
Wikipedia	http://en.wikipedia.org/wiki/Beta_Adrenergic_Receptor_Kinase

Licensable Technologies for ADRBK1
(Available from WIS Yeda, Salk, Tufts)

About This Section

(Reagents available from Applied Biosystems, Antibodies and assays by Cell Signaling Technology, Abcam, Novus Biologicals,
Sigma-Aldrich, R&D Systems, Millipore, Abnova, and/or Invitrogen, Clones available from OriGene,and/or Invitrogen, Drugs and/or compounds by Sigma-Aldrich,
Enzo Life Sciences, and/or Tocris Bioscience)
About This Section

Products for ADRBK1:

TaqMan ® Gene Expression Assays

TaqMan ® Genotyping Assays

Free SNP selection tool

Invitrogen iPath Pathways	Invitrogen BLOCK-iT™ RNAi
Invitrogen Antibodies	Invitrogen Assays
Invitrogen Clones	Invitrogen Q-PCR Products
Invitrogen Human Recombinant Kinases	Invitrogen Custom Antibody and Peptide Service
Invitrogen Proteins / Assays / Screening Services	Search Invitrogen catalog for ADRBK1-related products

	Millipore Custom Antibody & Bulk Services
	Millipore Preclinical / Clinical Development Services
	Millipore Immunoassay Services
	Millipore Target Screening & Profiling Services

	Predesigned and custom siRNAs for ADRBK1		Antibodies for ADRBK1
	Explore super-pooled esiRNAs		Browse proteins at Sigma-Aldrich
	Lentivirus-delivered shRNAs for ADRBK1		Browse small molecules at Sigma-Aldrich
	"Your Favorite Gene" Pathways		feedback

	Antibodies		Primer Pairs
	Cell Culture Products		ELISAs
	Flow Cytometry Kits		Protease Activity Assays & Reagents
	Cell Selection/Detection Kits & Reagents		ELISA/Assay Development Kits & Reagents
	Multiplex/Array Assay Kits & Reagents		ELISpot Kits & Development Modules
	Recombinant & Natural Proteins

	Recombinant Proteins (ADRBK1)
	Antibodies (ADRBK1)
	Chimera RNAi (ADRBK1)
	Custom Service for Mouse Mab
	Custom Service for Rabbit Pab from Full-length Protein

Antibodies & Assays for ADRBK1 (BARK1/GRK2)

	Recombinant Proteins (GRK2, GRK2 + 3)
	Antibodies (GRK2, GRK2 + 3)

Search OriGene for ADRBK1

Search Tocris compounds for ADRBK1

Search www.enzolifesicences.com for proteins, assays, substrates, inhibitors & antibodies

Antibodies for ADRBK1

GeneCards Homepage - Last full update: 1 Jul 2009 Incremental update: 13 Oct 2009

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Gene Index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

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ADRBK1 Gene at Home site.
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ADRBK1 Gene

protein-coding GIFtS: 68

Aliases &
Descriptions
for ADRBK1

Summaries
for ADRBK1

Genomic Location
for ADRBK1

Proteins
for ADRBK1

Protein Domains/
Families
for ADRBK1

Gene Function
for ADRBK1

Pathways & Interactions
for ADRBK1

Drugs & Compounds
for ADRBK1

Transcripts
for ADRBK1

Expression
for ADRBK1

Orthologs
for ADRBK1

Paralogs
for ADRBK1

SNPs/Variants
for ADRBK1

Disorders & Mutations
for ADRBK1

Medical News
for ADRBK1

Publications
for ADRBK1

Search for ADRBK1

Genome Databases showing ADRBK1

Other Databases showing ADRBK1

Specialized Databases showing ADRBK1

Licensable Technologies
for ADRBK1

Services
for ADRBK1

Gene Index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

ADRBK1 Gene

protein-coding GIFtS: 68

Aliases & Descriptionsfor ADRBK1

Summariesfor ADRBK1

Genomic Locationfor ADRBK1

Proteinsfor ADRBK1

Protein Domains/Familiesfor ADRBK1

Gene Functionfor ADRBK1

Pathways & Interactionsfor ADRBK1

Drugs & Compoundsfor ADRBK1

Transcriptsfor ADRBK1

Expression for ADRBK1

Orthologsfor ADRBK1

Paralogsfor ADRBK1

SNPs/Variantsfor ADRBK1

Disorders & Mutationsfor ADRBK1

Medical Newsfor ADRBK1

Publicationsfor ADRBK1

Search for ADRBK1

Genome Databases showing ADRBK1

Other Databases showing ADRBK1

Specialized Databases showing ADRBK1

Licensable Technologiesfor ADRBK1

Servicesfor ADRBK1

Gene Index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

Aliases &
Descriptions
for ADRBK1

Summaries
for ADRBK1

Genomic Location
for ADRBK1

Proteins
for ADRBK1

Protein Domains/
Families
for ADRBK1

Gene Function
for ADRBK1

Pathways & Interactions
for ADRBK1

Drugs & Compounds
for ADRBK1

Transcripts
for ADRBK1

Expression
for ADRBK1

Orthologs
for ADRBK1

Paralogs
for ADRBK1

SNPs/Variants
for ADRBK1

Disorders & Mutations
for ADRBK1

Medical News
for ADRBK1

Publications
for ADRBK1

Licensable Technologies
for ADRBK1

Services
for ADRBK1