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Aliases for ADRBK1 Gene

Aliases for ADRBK1 Gene

  • Adrenergic, Beta, Receptor Kinase 1 2 3 5
  • G-Protein Coupled Receptor Kinase 2 3 4
  • EC 2.7.11.15 4 63
  • Beta-ARK-1 3 4
  • BARK1 3 4
  • GRK2 3 4
  • Adrenergic Beta Receptor Kinase 1 3
  • BETA-ARK1 3
  • EC 2.7.11 63
  • BARK 4

External Ids for ADRBK1 Gene

Previous GeneCards Identifiers for ADRBK1 Gene

  • GC11P069548
  • GC11M068669
  • GC11P066809
  • GC11P066790
  • GC11P067033
  • GC11P063362

Summaries for ADRBK1 Gene

Entrez Gene Summary for ADRBK1 Gene

  • The product of this gene phosphorylates the beta-2-adrenergic receptor and appears to mediate agonist-specific desensitization observed at high agonist concentrations. This protein is an ubiquitous cytosolic enzyme that specifically phosphorylates the activated form of the beta-adrenergic and related G-protein-coupled receptors. Abnormal coupling of beta-adrenergic receptor to G protein is involved in the pathogenesis of the failing heart. [provided by RefSeq, Jul 2008]

GeneCards Summary for ADRBK1 Gene

ADRBK1 (Adrenergic, Beta, Receptor Kinase 1) is a Protein Coding gene. Diseases associated with ADRBK1 include Myocardial Infarction. Among its related pathways are DAG and IP3 signaling and Interleukin-3, 5 and GM-CSF signaling. GO annotations related to this gene include transferase activity, transferring phosphorus-containing groups and protein tyrosine kinase activity. An important paralog of this gene is GRK7.

UniProtKB/Swiss-Prot for ADRBK1 Gene

  • Specifically phosphorylates the agonist-occupied form of the beta-adrenergic and closely related receptors, probably inducing a desensitization of them. Key regulator of LPAR1 signaling. Competes with RALA for binding to LPAR1 thus affecting the signaling properties of the receptor. Desensitizes LPAR1 and LPAR2 in a phosphorylation-independent manner.

Tocris Summary for ADRBK1 Gene

  • Heterotrimeric G proteins are membrane bound GTPases that are linked to 7-TM receptors. Each G protein contains an alpha-, beta- and gamma-subunit and is bound to GDP in the 'off' state. Ligand binding causes a receptor conformational change, detaching the G protein and switching it 'on'.

Gene Wiki entry for ADRBK1 Gene

No data available for PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ADRBK1 Gene

Genomics for ADRBK1 Gene

Regulatory Elements for ADRBK1 Gene

Enhancers for ADRBK1 Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around ADRBK1 on UCSC Golden Path with GeneCards custom track

Promoters for ADRBK1 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around ADRBK1 on UCSC Golden Path with GeneCards custom track

Genomic Location for ADRBK1 Gene

Chromosome:
11
Start:
67,266,400 bp from pter
End:
67,286,558 bp from pter
Size:
20,159 bases
Orientation:
Plus strand

Genomic View for ADRBK1 Gene

Genes around ADRBK1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ADRBK1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ADRBK1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ADRBK1 Gene

Proteins for ADRBK1 Gene

  • Protein details for ADRBK1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P25098-ARBK1_HUMAN
    Recommended name:
    Beta-adrenergic receptor kinase 1
    Protein Accession:
    P25098
    Secondary Accessions:
    • B0ZBE1
    • Q13837
    • Q6GTT3

    Protein attributes for ADRBK1 Gene

    Size:
    689 amino acids
    Molecular mass:
    79574 Da
    Quaternary structure:
    • Interacts with GIT1 (By similarity). Interacts with, and phosphorylates chemokine-stimulated CCR5. Interacts with ARRB1. Interacts with LPAR1 and LPAR2. Interacts with RALA in response to LPAR1 activation. ADRBK1 and RALA mutually inhibit each others binding to LPAR1.

    Three dimensional structures from OCA and Proteopedia for ADRBK1 Gene

neXtProt entry for ADRBK1 Gene

Proteomics data for ADRBK1 Gene at MOPED

Post-translational modifications for ADRBK1 Gene

  • Ubiquitination at Lys 57, Lys 62, Lys 164, Lys 448, Lys 644, and Lys 677
  • Modification sites at PhosphoSitePlus

Other Protein References for ADRBK1 Gene

ENSEMBL proteins:
REFSEQ proteins:

Antibody Products

  • Cell Signaling Technology (CST) Antibodies for ADRBK1 (GRK2)
  • Abcam antibodies for GRK2

Domains & Families for ADRBK1 Gene

Suggested Antigen Peptide Sequences for ADRBK1 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

P25098

UniProtKB/Swiss-Prot:

ARBK1_HUMAN :
  • The PH domain binds anionic phospholipids and helps recruiting ADRBK1 from the cytoplasm to plasma membrane close to activated receptors. It mediates binding to G protein beta and gamma subunits, competing with G-apha subunits and other G-betagamma effectors.
  • Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. GPRK subfamily.
Domain:
  • The PH domain binds anionic phospholipids and helps recruiting ADRBK1 from the cytoplasm to plasma membrane close to activated receptors. It mediates binding to G protein beta and gamma subunits, competing with G-apha subunits and other G-betagamma effectors.
  • Contains 1 AGC-kinase C-terminal domain.
  • Contains 1 PH domain.
  • Contains 1 protein kinase domain.
  • Contains 1 RGS domain.
Family:
  • Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. GPRK subfamily.
genes like me logo Genes that share domains with ADRBK1: view

Function for ADRBK1 Gene

Molecular function for ADRBK1 Gene

GENATLAS Biochemistry:
beta-adrenergic receptor kinase 1,containing a CGG repeat in the 5utr
UniProtKB/Swiss-Prot CatalyticActivity:
ATP + [beta-adrenergic receptor] = ADP + [beta-adrenergic receptor] phosphate.
UniProtKB/Swiss-Prot EnzymeRegulation:
In contrast to other AGC family kinases, the catalytic activity is solely regulated by the binding of substrates and ligands, not by phosphorylation of the kinase domain.
UniProtKB/Swiss-Prot Function:
Specifically phosphorylates the agonist-occupied form of the beta-adrenergic and closely related receptors, probably inducing a desensitization of them. Key regulator of LPAR1 signaling. Competes with RALA for binding to LPAR1 thus affecting the signaling properties of the receptor. Desensitizes LPAR1 and LPAR2 in a phosphorylation-independent manner.

Enzyme Numbers (IUBMB) for ADRBK1 Gene

Gene Ontology (GO) - Molecular Function for ADRBK1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004674 protein serine/threonine kinase activity IEA --
GO:0047696 beta-adrenergic receptor kinase activity IEA,TAS --
genes like me logo Genes that share ontologies with ADRBK1: view
genes like me logo Genes that share phenotypes with ADRBK1: view

Animal Models for ADRBK1 Gene

MGI Knock Outs for ADRBK1:

Animal Model Products

CRISPR Products

No data available for Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for ADRBK1 Gene

Localization for ADRBK1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ADRBK1 Gene

Cytoplasm. Cell membrane.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for ADRBK1 Gene COMPARTMENTS Subcellular localization image for ADRBK1 gene
Compartment Confidence
cytosol 5
plasma membrane 5
endosome 2
mitochondrion 2
nucleus 2
cytoskeleton 1
endoplasmic reticulum 1
extracellular 1

Gene Ontology (GO) - Cellular Components for ADRBK1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0016020 membrane IEA,ISS --
genes like me logo Genes that share ontologies with ADRBK1: view

Pathways & Interactions for ADRBK1 Gene

genes like me logo Genes that share pathways with ADRBK1: view

SIGNOR curated interactions for ADRBK1 Gene

Activates:
Inactivates:
Is activated by:
Is inactivated by:
Other effect:

Gene Ontology (GO) - Biological Process for ADRBK1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0002029 desensitization of G-protein coupled receptor protein signaling pathway IEA,ISS --
GO:0006468 protein phosphorylation IEA --
GO:0007165 signal transduction IEA --
GO:0007173 epidermal growth factor receptor signaling pathway TAS --
GO:0007213 G-protein coupled acetylcholine receptor signaling pathway ISS --
genes like me logo Genes that share ontologies with ADRBK1: view

Drugs & Compounds for ADRBK1 Gene

(28) Drugs for ADRBK1 Gene - From: DrugBank, HMDB, and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Adenosine triphosphate Approved Nutra Target 0
Zinc Approved Pharma 2102

(27) Additional Compounds for ADRBK1 Gene - From: Tocris, HMDB, and Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
ADP
  • Adenosindiphosphorsaeure
  • Adenosine 5'-pyrophosphate
  • Adenosine diphosphate
  • Adenosine pyrophosphate
  • Adenosine-5'-diphosphate
Full agonist, Agonist 58-64-0
[D-Trp7,9,10]-Substance P
89430-38-6
mastoparan
72093-21-1
Mastoparan X
72093-22-2
NF 023
104869-31-0

(5) Tocris Compounds for ADRBK1 Gene

Compound Action Cas Number
[D-Trp7,9,10]-Substance P Inhibits M1 ACh receptor activation of Gq/11 89430-38-6
Mastoparan Activates Gi and Go 72093-21-1
Mastoparan X G protein activator peptide 72093-22-2
NF 023 Selective, competitive P2X1 antagonist 104869-31-0
SCH 202676 hydrobromide Inhibitor of ligand binding to G-protein-coupled receptors 265980-25-4
genes like me logo Genes that share compounds with ADRBK1: view

Transcripts for ADRBK1 Gene

Unigene Clusters for ADRBK1 Gene

Adrenergic, beta, receptor kinase 1:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for ADRBK1 Gene

ExUns: 1 ^ 2a · 2b ^ 3 ^ 4a · 4b ^ 5a · 5b ^ 6 ^ 7 ^ 8a · 8b ^ 9a · 9b ^ 10 ^ 11a · 11b ^ 12a · 12b ^ 13 ^ 14a · 14b ^ 15 ^ 16 ^ 17a · 17b ·
SP1: - - -
SP2: -
SP3: - - -
SP4:
SP5:
SP6:
SP7: - - - - - - - - - - - - - - - - -
SP8:
SP9:
SP10:
SP11: -

ExUns: 17c ^ 18a · 18b · 18c · 18d ^ 19a · 19b · 19c ^ 20a · 20b ^ 21a · 21b ^ 22a · 22b
SP1: - -
SP2:
SP3: - -
SP4:
SP5:
SP6:
SP7: - - - - - - - - - - - -
SP8:
SP9: - - -
SP10:
SP11: - -

Relevant External Links for ADRBK1 Gene

GeneLoc Exon Structure for
ADRBK1
ECgene alternative splicing isoforms for
ADRBK1

Expression for ADRBK1 Gene

mRNA expression in normal human tissues for ADRBK1 Gene

mRNA differential expression in normal tissues according to GTEx for ADRBK1 Gene

This gene is overexpressed in Whole Blood (x8.5).

Protein differential expression in normal tissues from HIPED for ADRBK1 Gene

This gene is overexpressed in Lymph node (22.1), Peripheral blood mononuclear cells (15.6), and Heart (10.5).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for ADRBK1 Gene



SOURCE GeneReport for Unigene cluster for ADRBK1 Gene Hs.83636

mRNA Expression by UniProt/SwissProt for ADRBK1 Gene

P25098-ARBK1_HUMAN
Tissue specificity: Expressed in peripheral blood leukocytes.
genes like me logo Genes that share expression patterns with ADRBK1: view

Protein tissue co-expression partners for ADRBK1 Gene

- Elite partner

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery for ADRBK1 Gene

Orthologs for ADRBK1 Gene

This gene was present in the common ancestor of animals.

Orthologs for ADRBK1 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia ADRBK1 35
  • 93.03 (n)
  • 98.4 (a)
ADRBK1 36
  • 98 (a)
OneToOne
dog
(Canis familiaris)
Mammalia ADRBK1 35
  • 92.74 (n)
  • 98.55 (a)
ADRBK1 36
  • 99 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Adrbk1 35
  • 89.85 (n)
  • 98.76 (a)
Adrbk1 16
Adrbk1 36
  • 99 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia ADRBK1 35
  • 99.61 (n)
  • 100 (a)
ADRBK1 36
  • 100 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Adrbk1 35
  • 90.32 (n)
  • 98.4 (a)
platypus
(Ornithorhynchus anatinus)
Mammalia ADRBK1 36
  • 95 (a)
OneToOne
chicken
(Gallus gallus)
Aves ADRBK1 35
  • 85.42 (n)
  • 92.15 (a)
ADRBK1 36
  • 92 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia ADRBK1 36
  • 92 (a)
OneToOne
zebrafish
(Danio rerio)
Actinopterygii adrbk2 36
  • 85 (a)
OneToMany
fruit fly
(Drosophila melanogaster)
Insecta Gprk1 37
  • 66 (a)
Gprk1 36
  • 65 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea W02B3.2 37
  • 63 (a)
grk-2 36
  • 64 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea CSA.9837 36
  • 59 (a)
ManyToMany
Species with no ortholog for ADRBK1:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)

Evolution for ADRBK1 Gene

ENSEMBL:
Gene Tree for ADRBK1 (if available)
TreeFam:
Gene Tree for ADRBK1 (if available)

Paralogs for ADRBK1 Gene

Paralogs for ADRBK1 Gene

genes like me logo Genes that share paralogs with ADRBK1: view

Variants for ADRBK1 Gene

Sequence variations from dbSNP and Humsavar for ADRBK1 Gene

SNP ID Clin Chr 11 pos Sequence Context AA Info Type
rs55696045 - 67,280,779(+) CAACA(C/T)CCACG nc-transcript-variant, reference, missense
VAR_040379 A colorectal adenocarcinoma sample
rs885833 -- 67,281,745(+) CCGGG(C/T)CCTAG intron-variant
rs948988 -- 67,278,001(-) CACAC(C/T)GACTC intron-variant
rs1009943 -- 67,281,168(+) GGAAG(C/G)CTGAC nc-transcript-variant, reference, missense

Structural Variations from Database of Genomic Variants (DGV) for ADRBK1 Gene

Variant ID Type Subtype PubMed ID
nsv897796 CNV Loss 21882294
nsv897797 CNV Loss 21882294
dgv1192n71 CNV Loss 21882294
nsv897800 CNV Loss 21882294
nsv468603 CNV Loss 19166990
nsv897801 CNV Loss 21882294
nsv897802 CNV Loss 21882294

Variation tolerance for ADRBK1 Gene

Residual Variation Intolerance Score: 2.58% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.06; 21.66% of all genes are more intolerant (likely to be disease-causing)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Relevant External Links for ADRBK1 Gene

Disorders for ADRBK1 Gene

MalaCards: The human disease database

(1) MalaCards diseases for ADRBK1 Gene - From: DISEASES, Novoseek, and GeneCards

Disorder Aliases PubMed IDs
myocardial infarction
  • myocardial infarction, protection against
- elite association - COSMIC cancer census association via MalaCards

Relevant External Links for ADRBK1

Genetic Association Database (GAD)
ADRBK1
Human Genome Epidemiology (HuGE) Navigator
ADRBK1
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
ADRBK1
genes like me logo Genes that share disorders with ADRBK1: view

No data available for UniProtKB/Swiss-Prot and Genatlas for ADRBK1 Gene

Publications for ADRBK1 Gene

  1. cDNA cloning and chromosomal localization of the human beta- adrenergic receptor kinase. (PMID: 2037065) Benovic J.L. … Lefkowitz R.J. (FEBS Lett. 1991) 2 3 4 67
  2. G protein-coupled receptor kinase 2 (GRK2) modulation and cell cycle progression. (PMID: 20080565) Penela P. … Mayor F. (Proc. Natl. Acad. Sci. U.S.A. 2010) 3 23
  3. [High glucose up-regulates GRK2 gene expression in H9C2 cardiomyoblasts in vitro]. (PMID: 20335112) Chen H.M. … Yu X.Y. (Nan Fang Yi Ke Da Xue Xue Bao 2010) 3 23
  4. Dynamic changes in lymphocyte GRK2 levels in cardiac transplant patients: a biomarker for left ventricular function. (PMID: 20443948) Bonita R.E. … Koch W.J. (Clin Transl Sci 2010) 3 23
  5. GRK2 activation by receptors: role of the kinase large lobe and carboxyl-terminal tail. (PMID: 19338266) Sterne-Marr R. … Tesmer J.J. (Biochemistry 2009) 3 23

Products for ADRBK1 Gene

Sources for ADRBK1 Gene

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