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Aliases for ADRB3 Gene

Aliases for ADRB3 Gene

  • Adrenoceptor Beta 3 2 3
  • Adrenergic, Beta-3-, Receptor 2 3
  • Beta-3 Adrenoreceptor 3 4
  • Beta-3 Adrenoceptor 3 4
  • Beta-3 Adrenergic Receptor 3
  • BETA3AR 3
  • ADRB3R 4
  • B3AR 4

External Ids for ADRB3 Gene

Summaries for ADRB3 Gene

Entrez Gene Summary for ADRB3 Gene

  • The protein encoded by this gene belongs to the family of beta adrenergic receptors, which mediate catecholamine-induced activation of adenylate cyclase through the action of G proteins. This receptor is located mainly in the adipose tissue and is involved in the regulation of lipolysis and thermogenesis. [provided by RefSeq, Feb 2009]

GeneCards Summary for ADRB3 Gene

ADRB3 (Adrenoceptor Beta 3) is a Protein Coding gene. Diseases associated with ADRB3 include obesity and morbid obesity. Among its related pathways are Signaling by GPCR and Activation of cAMP-Dependent PKA. GO annotations related to this gene include protein homodimerization activity and norepinephrine binding. An important paralog of this gene is TAAR9.

UniProtKB/Swiss-Prot for ADRB3 Gene

  • Beta-adrenergic receptors mediate the catecholamine-induced activation of adenylate cyclase through the action of G proteins. Beta-3 is involved in the regulation of lipolysis and thermogenesis

Tocris Summary for ADRB3 Gene

  • The adrenergic beta3 receptor (beta3-adrenoceptor) is a member of the adrenergic receptor group of G-protein-coupled receptors that also includes alpha1A, alpha1B, alpha1D, alpha2A, alpha2B, alpha2C, beta1 and beta2. They are located primarily in the small intestine, adipose tissue and vascular endothelium where they are involved in lipolysis, glucose uptake, cardio-inhibition and relaxation of colon, esophagus and bladder. The human beta3 receptor gene has been localized to chromosome 8 (8p12-8p11.1).

Gene Wiki entry for ADRB3 Gene

No data available for PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ADRB3 Gene

Genomics for ADRB3 Gene

Genomic Location for ADRB3 Gene

Start:
37,962,991 bp from pter
End:
37,966,965 bp from pter
Size:
3,975 bases
Orientation:
Minus strand

Genomic View for ADRB3 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for ADRB3 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ADRB3 Gene

Regulatory Elements for ADRB3 Gene

Proteins for ADRB3 Gene

  • Protein details for ADRB3 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P13945-ADRB3_HUMAN
    Recommended name:
    Beta-3 adrenergic receptor
    Protein Accession:
    P13945
    Secondary Accessions:
    • Q4JFT4

    Protein attributes for ADRB3 Gene

    Size:
    408 amino acids
    Molecular mass:
    43519 Da
    Quaternary structure:
    No Data Available

    Three dimensional structures from OCA and Proteopedia for ADRB3 Gene

neXtProt entry for ADRB3 Gene

Proteomics data for ADRB3 Gene at MOPED

Post-translational modifications for ADRB3 Gene

Other Protein References for ADRB3 Gene

ENSEMBL proteins:
Reactome Protein details:
REFSEQ proteins:

No data available for DME Specific Peptides for ADRB3 Gene

Domains for ADRB3 Gene

Gene Families for ADRB3 Gene

HGNC:
  • ADRB :GPCR / Class A : Adrenoceptors : beta
IUPHAR :

UniProtKB/Swiss-Prot:

ADRB3_HUMAN
Family:
  • Belongs to the G-protein coupled receptor 1 family. Adrenergic receptor subfamily. ADRB3 sub-subfamily.:
    • P13945
genes like me logo Genes that share domains with ADRB3: view

Function for ADRB3 Gene

Molecular function for ADRB3 Gene

GENATLAS Biochemistry: adrenergic,beta-3-,receptor,G protein coupled receptor superfamily,mostly expressed in brown and white adipose tissue,activating adenylate cyclase,susceptibility gene for hypertension in the Sardinian population (polymorphism W64R) and for obesity in Mexican-American population
UniProtKB/Swiss-Prot Function: Beta-adrenergic receptors mediate the catecholamine-induced activation of adenylate cyclase through the action of G proteins. Beta-3 is involved in the regulation of lipolysis and thermogenesis

Gene Ontology (GO) - Molecular Function for ADRB3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004930 G-protein coupled receptor activity --
GO:0004939 beta-adrenergic receptor activity IDA 15123695
GO:0005515 protein binding IPI 15123695
GO:0015052 beta3-adrenergic receptor activity IMP 9892244
GO:0031699 beta-3 adrenergic receptor binding IEA --
genes like me logo Genes that share ontologies with ADRB3: view
genes like me logo Genes that share phenotypes with ADRB3: view

Animal Models for ADRB3 Gene

MGI Knock Outs for ADRB3:

No data available for Enzyme Numbers (IUBMB) , miRNA , Transcription Factor Targeting and HOMER Transcription for ADRB3 Gene

Localization for ADRB3 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ADRB3 Gene

Cell membrane; Multi-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for ADRB3 Gene COMPARTMENTS Subcellular localization image for ADRB3 gene
Compartment Confidence
plasma membrane 5
mitochondrion 2
nucleus 2
extracellular 1

Gene Ontology (GO) - Cellular Components for ADRB3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IEA --
GO:0005886 plasma membrane TAS --
GO:0005887 integral component of plasma membrane TAS 1718744
GO:0016020 membrane --
GO:0016021 integral component of membrane --
genes like me logo Genes that share ontologies with ADRB3: view

Pathways for ADRB3 Gene

genes like me logo Genes that share pathways with ADRB3: view

Gene Ontology (GO) - Biological Process for ADRB3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0002024 diet induced thermogenesis IEA --
GO:0002025 vasodilation by norepinephrine-epinephrine involved in regulation of systemic arterial blood pressure IEA --
GO:0002032 NOT desensitization of G-protein coupled receptor protein signaling pathway by arrestin IDA 15123695
GO:0005975 carbohydrate metabolic process TAS 2570461
GO:0006091 generation of precursor metabolites and energy TAS 2570461
genes like me logo Genes that share ontologies with ADRB3: view

Compounds for ADRB3 Gene

(5) Tocris Compounds for ADRB3 Gene

Compound Action Cas Number
BRL 37344, sodium salt beta3 agonist [127299-93-8]
CL 316243 disodium salt Highly selective beta3 agonist [151126-84-0]
L-748,337 Selective beta3 antagonist [244192-94-7]
SR 58611A hydrochloride beta3 agonist; displays anxiolytic and antidepressant effects [121524-09-2]
SR 59230A hydrochloride Potent and selective beta3 antagonist [1135278-41-9]

(2) HMDB Compounds for ADRB3 Gene

Compound Synonyms Cas Number PubMed IDs
Norepinephrine
  • (-)-(R)-Norepinephrine
51-41-2
Propranolol
  • Dociton
525-66-6

(11) Drugbank Compounds for ADRB3 Gene

Compound Synonyms Cas Number Type Actions PubMed IDs
Arbutamine
128470-16-6 target agonist
Bopindolol
69010-88-4 target
Bupranolol
  • Bupranol
23284-25-5 target antagonist
Clenbuterol
37148-27-9 target agonist
Droxidopa
  • Droxydopa
23651-95-8 target agonist

(22) IUPHAR Ligand for ADRB3 Gene

Ligand Type Action Affinity Pubmed IDs
[125I]ICYP Antagonist Antagonist 11.1
L 755507 Agonist Full agonist 10.1
carvedilol Antagonist Antagonist 9.9
ICI 118551 Antagonist Inverse agonist 9.5
CGP 12177 Antagonist Antagonist 9.4
SR59230A Antagonist Antagonist 9.3
bupranolol Antagonist Antagonist 9.1
L742791 Agonist Agonist 8.8
carazolol Agonist Full agonist 8.7
tertatolol Antagonist Antagonist 8.6
nadolol Antagonist Antagonist 8.6
L-748337 Antagonist Antagonist 8.4
BRL 37344 Agonist Full agonist 7
bunolol Antagonist Antagonist 6.8
isoprenaline Agonist Full agonist 6.4
(plusmn)-adrenaline Agonist Full agonist 6.2
(-)-noradrenaline Agonist Full agonist 6
CGP 20712A Antagonist Antagonist 5.7
SR58611A Agonist Full agonist 5.2
CL316243 Agonist Agonist 5.2
propranolol Inhibitor Inhibition
L748328 Antagonist Antagonist

(41) Novoseek inferred chemical compound relationships for ADRB3 Gene

Compound -log(P) Hits PubMed IDs
brl37344 84.5 5
cgp 12177 78.8 2
bupranolol 67.7 5
isoproterenol 61.9 12
benzenesulfonamide 61.9 3

(1) PharmGKB related drug/compound annotations for ADRB3 Gene

Drug/compound Annotation
olanzapine CA
genes like me logo Genes that share compounds with ADRB3: view

Transcripts for ADRB3 Gene

mRNA/cDNA for ADRB3 Gene

Unigene Clusters for ADRB3 Gene

Adrenoceptor beta 3:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for ADRB3 Gene

No ASD Table

Relevant External Links for ADRB3 Gene

GeneLoc Exon Structure for
ADRB3
ECgene alternative splicing isoforms for
ADRB3

Expression for ADRB3 Gene

mRNA expression in normal human tissues for ADRB3 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for ADRB3 Gene

This gene is overexpressed in Ovary (14.6), Fallopian Tube (6.9), Esophagus - Muscularis (6.5), Bladder (5.9), and Esophagus - Gastroesophageal Junction (4.4).

SOURCE GeneReport for Unigene cluster for ADRB3 Gene Hs.2549

mRNA Expression by UniProt/SwissProt for ADRB3 Gene

P13945-ADRB3_HUMAN
Tissue specificity: Expressed mainly in adipose tissues
genes like me logo Genes that share expressions with ADRB3: view

Orthologs for ADRB3 Gene

This gene was present in the common ancestor of animals.

Orthologs for ADRB3 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia ADRB3 36
  • 99.02 (n)
  • 98.28 (a)
ADRB3 37
  • 98 (a)
OneToOne
cow
(Bos Taurus)
Mammalia ADRB3 36
  • 86.91 (n)
  • 86.17 (a)
ADRB3 37
  • 86 (a)
OneToOne
dog
(Canis familiaris)
Mammalia ADRB3 36
  • 86.37 (n)
  • 83.29 (a)
ADRB3 37
  • 83 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Adrb3 36
  • 81.33 (n)
  • 81.84 (a)
Adrb3 16
Adrb3 37
  • 81 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia ADRB3 37
  • 77 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Adrb3 36
  • 80.9 (n)
  • 81.33 (a)
chicken
(Gallus gallus)
Aves ADRB3 37
  • 45 (a)
OneToOne
LOC430991 36
  • 71.31 (n)
  • 67.25 (a)
lizard
(Anolis carolinensis)
Reptilia ADRB3 37
  • 46 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia LOC100487086 36
  • 61.81 (n)
  • 62.15 (a)
zebrafish
(Danio rerio)
Actinopterygii adrb3a 36
  • 56.57 (n)
  • 57.24 (a)
adrb3a 37
  • 41 (a)
OneToMany
adrb3b 37
  • 39 (a)
OneToMany
fruit fly
(Drosophila melanogaster)
Insecta oa2 37
  • 23 (a)
ManyToMany
Octbeta2R 37
  • 23 (a)
ManyToMany
CG7431 38
  • 40 (a)
CG6989 38
  • 37 (a)
CG6919 38
  • 36 (a)
DopR 38
  • 34 (a)
worm
(Caenorhabditis elegans)
Secernentea M03F4.3 38
  • 39 (a)
Species with no ortholog for ADRB3:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for ADRB3 Gene

ENSEMBL:
Gene Tree for ADRB3 (if available)
TreeFam:
Gene Tree for ADRB3 (if available)

Paralogs for ADRB3 Gene

Paralogs for ADRB3 Gene

genes like me logo Genes that share paralogs with ADRB3: view

Variants for ADRB3 Gene

Polymorphic Variants from UniProtKB/Swiss-Prot for ADRB3 Gene

P13945-ADRB3_HUMAN
The variant Arg-64 seems to be associated with weight gain (obesity) and is also associated with susceptibility to non-insulin-dependent diabetes mellitus (NIDDM)

Sequence variations from dbSNP and Humsavar for ADRB3 Gene

SNP ID Clin Chr 08 pos Sequence Context AA Info Type MAF
rs4993 -- 37,966,652(-) CCCCC(A/G)AGAGC utr-variant-5-prime
rs4994 other, - 37,966,280(-) TCGCC(C/T)GGACT missense, reference
rs4995 - 37,965,676(-) GGGGA(C/G/T)GTGCG reference, missense
rs4996 -- 37,965,342(-) GCCCG(C/T)CCGGC reference, synonymous-codon
rs4997 -- 37,965,251(-) CCGGG(G/T)CAGAG intron-variant

Structural Variations from Database of Genomic Variants (DGV) for ADRB3 Gene

Variant ID Type Subtype PubMed ID
nsv890719 CNV Loss 21882294

Relevant External Links for ADRB3 Gene

HapMap Linkage Disequilibrium report
ADRB3
Human Gene Mutation Database (HGMD)
ADRB3

Disorders for ADRB3 Gene

(1) OMIM Diseases for ADRB3 Gene (109691)

(2) University of Copenhagen DISEASES for ADRB3 Gene

(41) Novoseek inferred disease relationships for ADRB3 Gene

Disease -log(P) Hits PubMed IDs
obesity 79 138
insulin resistance 74.1 73
niddm 69.8 53
overactive bladder 51.6 5
insulin sensitivity 49.2 10

Genatlas disease for ADRB3 Gene

excess capacity to gain weight in patients with insulin resistance,early onset non insulin dependent diabetes and/or morbid obesity,with fatty liver

Relevant External Links for ADRB3

Genetic Association Database (GAD)
ADRB3
Human Genome Epidemiology (HuGE) Navigator
ADRB3
genes like me logo Genes that share disorders with ADRB3: view

No data available for UniProtKB/Swiss-Prot for ADRB3 Gene

Publications for ADRB3 Gene

  1. Association of Trp64Arg mutation of the beta3-adrenergic-receptor with NIDDM and body weight gain. (PMID: 8721782) Fujisawa T. … Ogihara T. (Diabetologia 1996) 3 4 23 49
  2. Association of a genetic variation in the beta 3-adrenergic receptor gene with coronary heart disease among Japanese. (PMID: 9126344) Higashi K. … Nakamura H. (Biochem. Biophys. Res. Commun. 1997) 3 23 49
  3. Genetic variation in the beta 3-adrenergic receptor and an increased capacity to gain weight in patients with morbid obesity. (PMID: 7609752) Clement K. … Strosberg A.D. (N. Engl. J. Med. 1995) 3 4 23
  4. The promoter and intron/exon structure of the human and mouse beta 3- adrenergic-receptor genes. (PMID: 8389293) van Spronsen A. … Emorine L.J. (Eur. J. Biochem. 1993) 3 4 23
  5. Studies of the synergistic effect of the Trp/Arg64 polymorphism of the beta3-adrenergic receptor gene and the -3826 A-->G variant of the uncoupling protein-1 gene on features of obesity and insulin resistance in a population-based sample of 379 young Danish subjects. (PMID: 10999801) Urhammer S.A. … Pedersen O. (J. Clin. Endocrinol. Metab. 2000) 3 23 49

Products for ADRB3 Gene

Sources for ADRB3 Gene

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