Aliases for ADRB3 Gene
External Ids for ADRB3 Gene
Previous GeneCards Identifiers for ADRB3 Gene
The protein encoded by this gene belongs to the family of beta adrenergic receptors, which mediate catecholamine-induced activation of adenylate cyclase through the action of G proteins. This receptor is located mainly in the adipose tissue and is involved in the regulation of lipolysis and thermogenesis. [provided by RefSeq, Feb 2009]
GeneCards Summary for ADRB3 Gene
ADRB3 (Adrenoceptor Beta 3) is a Protein Coding gene. Diseases associated with ADRB3 include obesity due to melanocortin 4 receptor deficiency and morbid obesity. Among its related pathways are Signaling by GPCR and Activation of cAMP-Dependent PKA. GO annotations related to this gene include protein homodimerization activity and norepinephrine binding. An important paralog of this gene is TAAR9.
UniProtKB/Swiss-Prot for ADRB3 Gene
Beta-adrenergic receptors mediate the catecholamine-induced activation of adenylate cyclase through the action of G proteins. Beta-3 is involved in the regulation of lipolysis and thermogenesis
The adrenergic beta3 receptor (beta3-adrenoceptor) is a member of the adrenergic receptor group of G-protein-coupled receptors that also includes alpha1A, alpha1B, alpha1D, alpha2A, alpha2B, alpha2C, beta1 and beta2. They are located primarily in the small intestine, adipose tissue and vascular endothelium where they are involved in lipolysis, glucose uptake, cardio-inhibition and relaxation of colon, esophagus and bladder. The human beta3 receptor gene has been localized to chromosome 8 (8p12-8p11.1).