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ADRB3 Gene

protein-coding GIFtS: 66

GC08M037939

adrenergic, beta-3-, receptor
Symbol approved by the HUGO Gene Nomenclature Committee (HGNC) database

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc , and/or ⁷Ensembl, ⁸miRBase)
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Aliases
ADRB3R ^³
B3AR ^³
BETA3AR ^²
FLJ99960 ^²

Descriptions
Beta-3 adrenoceptor ^³
Beta-3 adrenoreceptor ^³
adrenergic, beta-3-, receptor ^²

External Ids
HGNC: 288¹
Entrez Gene: 155²
UniProtKB: P13945³
Ensembl: ENSG00000188778⁷

Search outside databases for aliases for ADRB3 gene

Previous GC identifers: GC08P037473 GC08M038084 GC08M9E0062

(According to Entrez Gene, Wikipedia's Gene Wiki,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

EntrezGene summary for ADRB3:

The protein encoded by this gene belongs to the family of beta adrenergic receptors, which mediate

catecholamine-induced activation of adenylate cyclase through the action of G proteins. This

receptor is located mainly in the adipose tissue and is involved in the regulation of lipolysis

and thermogenesis. [provided by RefSeq]

UniProtKB/Swiss-Prot: ADRB3_HUMAN, P13945

Function: Beta-adrenergic receptors mediate the catecholamine-induced activation of adenylate

cyclase through the action of G proteins. Beta-3 is involved in the regulation of lipolysis and

thermogenesis

Gene Wiki entry for ADRB3 (Beta-3_adrenergic_receptor)

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 36),
and/or miRBase,
Genomic Views according to UCSC and Ensembl, Transcription factor binding sites according to SABiosciences)
About This Section

Genomic View:

UCSC Golden Path with GeneCards custom track

Transcription factor binding sites upstream to the ADRB3 gene

Entrez Gene cytogenetic band: 8p12-p11.2 Ensembl cytogenetic band: 8p12 HGNC cytogenetic band: 8p12

ADRB3 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)

GeneLoc gene densities for chromosome 8 GeneLoc Exon Structure

GeneLoc location for GC08M037939: (about GC identifiers)

Start:	37,939,673 bp from pter
End:	37,943,341 bp from pter
Size:	3,669 bases
Orientation:	minus strand

RefSeq DNA sequence:

NC_000008.9 NT_007995.14

(According to ¹UniProtKB, and/or Ensembl, Phosphorylation sites according to ²Phosphosite, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Enzo Life Sciences, Abnova, OriGene and/or, Abcam,
Biochemical Assays by Invitrogen, Millipore, R&D Systems, Cell Signaling Technology, and/or Enzo Life Sciences, Ontologies according to Gene Ontology Consortium 01 Apr 2009 and Entrez Gene, Antibodies by Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Cell Signaling Technology, Abcam, Abnova, and/or Novus Biologicals)
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UniProtKB/Swiss-Prot: ADRB3_HUMAN, P13945 (See protein sequence)

Recommended Name: Beta-3 adrenergic receptor

Size: 408 amino acids; 43519 Da

Subcellular location: Cell membrane; Multi-pass membrane protein

PDB structures from and Proteopedia :

2CDW (3D)

Secondary accessions: Q4JFT4

REFSEQ proteins: NP_000016.1

ENSEMBL proteins:

ENSP00000343782

Human Recombinant Proteins

	Browse Drug Discovery Central at Invitrogen for human recombinant proteins
	Millipore Purified and/or Recombinant ADRB3 Protein
	Sigma-Aldrich CompoZr ZFN for ADRB3
	Browse R&D Systems for human recombinant proteins
	Browse recombinant and purified proteins available from Enzo Life Sciences
	Recombinant Proteins from Abcam (beta 3 Adrenergic Receptor)
	Human Recombinant Proteins from Abnova (ADRB3)

Browse Origene for full length recombinant human proteins expressed in human HEK293 cells

4 Gene Ontology (GO) cellular component terms (links to tree view):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005624	membrane fraction	IEA	--
GO:0005886	plasma membrane	TAS	1718744
GO:0005887	integral to plasma membrane	TAS	1718744
GO:0043235	receptor complex	IDA	15123695

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Antibodies for ADRB3:

	Browse Antibodies Central at Invitrogen
	Millipore Mono- and Polyclonal Antibodies for the study of ADRB3
	Sigma-Aldrich Antibodies for ADRB3
	Browse R&D Systems for Antibodies
	Antibodies from Abcam (beta 3 Adrenergic Receptor), each with their Abpromise^SM
	Monoclonal and Polyclonal Antibodies from Abnova (ADRB3)
	Novus Biologicals Antibodies for ADRB3

Assays for ADRB3:

	Invitrogen Assays for ADRB3
	Browse Kits and Assays available from Millipore
	Browse R&D Systems for biochemical assays
	Browse biochemical assays available from Enzo Life Sciences

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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Graphical View of Domain Structure for InterPro Entry P13945

ProtoNet protein and cluster: P13945

2 Blocks protein families:

IPB000681 Beta-3 adrenergic receptor signature

IPB002233 Adrenergic receptor signature

UniProtKB/Swiss-Prot: ADRB3_HUMAN, P13945

Similarity: Belongs to the G-protein coupled receptor 1 family

(According to MGI Jun 06 2009, UniProtKB, IUBMB,and/or Genatlas,
shRNA from OriGene, Sigma-Aldrich, RNAi from Sigma-Aldrich,
RNAi Products, Clones, and Q-PCR Products from Invitrogen, Millipore, OriGene, and/or Abnova, siRNAs from Applied Biosystems, SYBR primers from OriGene, Cell-based Assays from Millipore, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
About This Section

Inhib. RNA:		Invitrogen RNAi Products for gene knock-down (ADRB3)
		Browse for Gene Knock-down Tools from Millipore
		Abnova Chimera RNAi Products for Gene knock-down (ADRB3)

OriGene 29mer shRNA kit in GFP-retroviral vector: NM_000025

Applied Biosystems Silencer® siRNAs for ADRB3

Sigma-Aldrich siRNA and siRNA Panels for ADRB3

Sigma-Aldrich shRNA Panels and shRNA for ADRB3

Explore Sigma-Aldrich super-pooled esiRNAs

Clones:		Invitrogen Clones for ADRB3
		Millipore Clones for the Expression of ADRB3

OriGene GFP tagged cDNA clone in CMV expression vector: NM_000025
Myc/DDK tagged cDNA clone in CMV expression vector: NM_000025
untagged cDNA clone in CMV expression vector: NM_000025

Primers:

Browse Quantitative PCR Central at Invitrogen for Q-PCR LUX™ Primers

OriGene genome-wide validated SYBR primer pairs: NM_000025

UniProtKB/Swiss-Prot: ADRB3_HUMAN, P13945

Function: Beta-adrenergic receptors mediate the catecholamine-induced activation of adenylate

cyclase through the action of G proteins. Beta-3 is involved in the regulation of lipolysis and

thermogenesis

Genatlas biochemistry entry for ADRB3:

adrenergic,beta-3-,receptor,G protein coupled receptor superfamily,mostly expressed in brown and

white adipose tissue,activating adenylate cyclase,susceptibility gene for hypertension in the

Sardinian population (polymorphism W64R) and for obesity in Mexican-American population

5 MGI mutant phenotypes (inferred from 2 alleles) (MGI details for Adrb3):

adipose tissue

behavior/neurological

endocrine/exocrine gland

growth/size

homeostasis/metabolism

5/6 Gene Ontology (GO) molecular function terms (links to tree view) (see all 6 ):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0004872	receptor activity	IEA	--
GO:0004930	G-protein coupled receptor activity	IEA	--
GO:0015052	beta3-adrenergic receptor activity	IMP	9892244
GO:0031699	beta-3 adrenergic receptor binding	IEA	--
GO:0042803	protein homodimerization activity	IDA	15123695

About this table

(Pathways according to Invitrogen (maps by GeneGo), Millipore, Cell Signaling Technology, Sigma-Aldrich, KEGG and/or UniProtKB,
Sets of similar genes according to GeneDecks, Proteins Network according to SABiosciences, Interactions according to ¹UniProtKB, ²MINT, and/or ³STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
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3 Sigma-Aldrich "Your Favorite Gene" Pathways for ADRB3 (Your Favorite Gene powered by Ingenuity)

cAMP-mediated Signaling
G-Protein Coupled Receptor Signaling
Cardiac Hypertrophy Signaling

GeneDecks ADRB3 for the pathways selected above

About GeneDecksing

Gene Network Central^TM Interacting Genes and Proteins Network for ADRB3

5/36 Interacting proteins for ADRB3 (ENSP00000343782³) via UniProtKB, MINT, and/or STRING (see all 36 )

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
ADRB2	ENSP00000305372³	STRING (score=.963)
GNAS	ENSP00000302237³	STRING (score=.961)
PPARG	ENSP00000287820³	STRING (score=.95)
INS	ENSP00000370731³	STRING (score=.928)
ADCY2	ENSP00000371971³	STRING (score=.909)

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5/14 Gene Ontology (GO) biological process terms (links to tree view) (see all 14 ):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0002024	diet induced thermogenesis	IEA	--
GO:0002025	vasodilation by norepinephrine-epinephrine involved in regulation of systemic arterial blood pressure	IEA	--
GO:0002032	NOT desensitization of G-protein coupled receptor protein signaling pathway by arrestin	IDA	15123695
GO:0005975	carbohydrate metabolic process	TAS	2570461
GO:0006091	generation of precursor metabolites and energy	TAS	2570461

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(Chemical Compounds according to UniProtKB, Enzo Life Sciences, Sigma-Aldrich, Tocris Bioscience, and/or Novoseek and Drugs according to Enzo Life Sciences and/or PharmGKB)
About This Section

Enzo Life Sciences drugs & compounds for ADRB3

Sigma-Aldrich Small Molecules for ADRB3:

Antagonist Blocker Agonist

Compounds for ADRB3 available from Tocris Bioscience

Compound	Action	CAS number
BRL 37344, sodium salt	beta3 agonist	[127299-93-8]
L-748,337	Selective beta3 antagonist	[244192-94-7]
SR 59230A hydrochloride	Potent and selective beta3 antagonist	[174689-39-5]
CL 316243 disodium salt	Highly selective beta3 agonist	[151126-84-0]

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10/18 Novoseek chemical compound relationships for ADRB3 gene (see all 18 )

Compound	Score	Articles	PubMed IDs for Articles with Shared Sentences (# sentences)
glucose	58.67	61	9828912 (4), 9826220 (3), 9845761 (3), 9313101 (2) (see all 35)
lipid	46.77	49	18482921 (4), 12370850 (3), 9845761 (3), 11003049 (3) (see all 31)
catecholamine	37.41	2	12149260 (1), 12580782 (1)
disodium	36.95	2	12736154 (1), 10207024 (1)
c-peptide	32.88	1	9845761 (1)
cholesterol	32.11	7	18924534 (2), 11798745 (1), 9208352 (1), 12917707 (1) (see all 5)
cyclic amp	30.15	2	10952688 (1), 9915482 (1)
fatty acid	29.92	15	12370850 (2), 9690058 (2), 8318015 (1), 10443326 (1) (see all 8)
glycogen	29.73	10	8960833 (2), 10707551 (1), 9326333 (1), 11965829 (1) (see all 7)
indole	12.22	4	15684518 (2), 15653351 (1)

About this table

(GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 219 Homo sapiens; Jun 2 2009) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView,
non coding RNAs according to RNAdb,
ESTs according to GeneTide,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from Invitrogen, Millipore, and/or Abnova,
siRNAs from Applied Biosystems, Sigma-Aldrich,
shRNA from Sigma-Aldrich, OriGene,
Tagged/untagged cDNA clones from OriGene,
Expression Assays from Applied Biosystems)
About This Section

Inhib. RNA:		Invitrogen RNAi Products for gene knock-down (ADRB3)
		Browse for Gene Knock-down Tools from Millipore
		Abnova Chimera RNAi Products for Gene knock-down (ADRB3)

OriGene 29mer shRNA kit in GFP-retroviral vector: NM_000025

Sigma-Aldrich siRNA and siRNA Panels for ADRB3

Sigma-Aldrich shRNA Panels and shRNA for ADRB3

Explore Sigma-Aldrich super-pooled esiRNAs

Applied Biosystems Silencer® siRNAs:

NM_000025

REFSEQ mRNAs for ADRB3 gene:

NM_000025.2

Applied Biosystems TaqMan ® Gene Expression Assays:

NM_000025

              OriGene GFP tagged cDNA clone in CMV expression vector: NM_000025
                                 Myc/DDK tagged cDNA clone in CMV expression vector: NM_000025
                                 untagged cDNA clone in CMV expression vector: NM_000025

Additional cDNA sequence:

AK293033.1 AK313857.1 AY487247.1 BC075017.2 S53291.1 X70811.1

2 DOTS entries:

DT.455704 DT.100741406

24/28 AceView cDNA sequences (see all 28 ):

AY487247 AL553958 X70811 BM728296 BC075017 AL553957 NM_000025 S53291

AL550996 BV194193 BX281822 BV198899 BV198900 BV198897 BV198898 AL550664

BM543956 BV183211 BV194192 AI276134 AL574813 BM546330 BP381136 BQ024407

highest scoring ESTs for ADRB3:

X70811 AU077348 AU100315 AY487247 BM546330 S53291 AI276134 AL550664 AL550996 AL553957

Unigene Cluster for ADRB3:

Adrenergic, beta-3-, receptor

Hs.2549 [show with all ESTs]

Unigene Representative Sequence: NM_000025

GeneLoc Exon Structure

1 Ensembl transcript including schematic representation:

ENST00000345060

(Experimental results according to ¹GeneNote and GNF BioGPS,
probe sets-to-genes annotations according to ²GeneAnnot , ³GeneTide , Sets of similar genes according to GeneDecks, Electronic Northern calculations according to data from UniGene (Build 219 Homo sapiens), SAGE tags according to CGAP, plus additional links to SOURCE, and/or GNF BioGPS, and/or EXPOLDB, and/or UniProtKB,
Expression Assays from Applied Biosystems )
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ADRB3 expression in normal and diseased human tissues

Applied Biosystems TaqMan ® Gene Expression Assays for ADRB3

¹ / ² / ³

5 probe-sets matching ADRB3 gene

Affymetrix probe-set	Array	# genes	Sensitivity	Specificity	Correlation	Length	Gb_Accession	Consensus	Uniqueness	Score	Rank
Affymetrix probe-set	Array	GeneAnnot data			GeneNote data		GeneTide data
33465_at²^{, 3}	U95-A	1	1.00	1.00	1.00	1.00	X70811	1.00	1.00	1.00	1
206812_at²^{, 3}	U133-A	1	1.00	1.00	--	--	NM_000025	0.60	1.00	0.82	1
217303_s_at²	U133-A	1	1.00	1.00	--	--	--	--	--	--	--
206812_at²	U133Plus2	1	1.00	1.00	--	--	--	--	--	--	--
217303_s_at²	U133Plus2	1	1.00	1.00	--	--	--	--	--	--	--

About this table

Data from

(Publications) and GNF BioGPS
About these images
About these images

CGAP SAGE TAG: GTGTGTGTGT

SOURCE GeneReport for Unigene cluster: Hs.2549
Expression variation in blood from EXPOLDB for ADRB3
UniProtKB/Swiss-Prot: ADRB3_HUMAN, P13945
Tissue specificity: Expressed mainly in adipose tissues

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD and/or ⁵MGI Jun 06 2009, with possible further links to Flybase and/or WormBase, Gene Trees according to Ensembl)
About This Section

Orthologs for ADRB3 gene from 5/8 species (see all 8 )

Organism	Gene	Locus	Description	Human Similarity	NCBI accessions
dog (Canis familiaris)	ADRB3¹	--	adrenergic, beta-3-, receptor	86.37(n) 83.29(a)	442979 NM_001003377.1 NP_001003377.1
chimpanzee (Pan troglodytes)	ADRB3¹	--	adrenergic, beta-3-, receptor	99.02(n) 98.28(a)	464113 XM_519708.2 XP_519708.2
cow (Bos taurus)	ADRB3¹	--	adrenergic, beta-3-, receptor	86.91(n) 86.17(a)	281606 NM_174232.2 NP_776657.1
rat (Rattus norvegicus)	Adrb3¹	--	adrenergic, beta-3-, receptor	81.9(n) 82.86(a)	25645 NM_013108.1 NP_037240.1
mouse (Mus musculus)	Adrb3^{1, 5}	8 (10.00 cM)⁵	adrenergic receptor, beta 3^{1, 5}	82.64(n)¹ 84.11(a)¹	11556¹ NM_013462.3¹ NP_038490.2¹ AF193027⁵ AK136495⁵ (see all 10)

About this table Species with no ortholog for ADRB3

ENSEMBL Gene Tree for ADRB3

(Paralogs according to ¹HomoloGene
and ²Ensembl, Pseudogenes according to ³Pseudogene.org)
About This Section

Paralogs for ADRB3 gene

ADRB2² ADRB1²

(According to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, and UniProtKB, Linkage Disequilibrium by HapMap, Genotyping Reagents from Applied Biosystems)
About This Section

UniProtKB/Swiss-Prot: ADRB3_HUMAN, P13945

Polymorphism: The variant Arg-64 seems to be associated with weight gain (obesity) and to is also

associated with susceptibility to non-insulin-dependent diabetes mellitus (NIDDM)

10/81 NCBI SNPs in ADRB3 are shown (see all 81 )
(Click for Applied Biosystems TaqMan ® Genotyping Assay) (see all 38)

AB	SNP ID	Valid	Chr 8 pos	Sequence	Recs	AA Chg	Type	More	Recs	Pop	Total sample	More
AB	Genomic Data				Transcription Data				Allele Frequencies
				--	--	--		--	--			--
	rs9694197^1,2	C,F	37939250(+)	`CAGACA/GCCAGA`	1	--	ng5¹		2	NS	82
	rs4995^1,2	C,F	37942351(-)	`GGGGAC/TGTGCG`	1	T/M	mis¹ ese³		2	MN	170
	rs4998^1,2	C,F	37940643(-)	`TCCAGG/CTGCCG`	1	--	ut3¹ ese³		5	MN EU NS	1267
	rs4994^1,2	C,F	37942955(-)	`TCGCCT/CGGACT`	1	R/W	mis¹		14	MN EA CSAM NS	2638
	rs4999^1,2	C,F	37940536(-)	`TCCTTC/TTGCCA`	1	--	ut3¹ ese³		3	MN NS	174
	rs3750241^1,2	C	37940216(-)	`CCTCCG/ATTTGT`	1	--	ut3¹		3	NS NA	159
	rs34434657^1,2	F	37939879(-)	`TGCCTT/AACATG`	1	--	ut3¹		2	NS	94
	rs34619057^1,2	F	37939587(-)	`TTCTAA/TGGAAA`	1	--	ng5¹		2	NS	94
	rs36031925^1,2	F	37942088(-)	`ACTTTC/TGCAGC`	1	R/C	mis¹		2	NS	92
	rs35155257^1,2	F	37940851(-)	`AACCTG/ATGGAA`	1	--	ut3¹		2	NS	92

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HapMap Linkage Disequilibrium images for ADRB3 (up to first 250kb)

(in which this Gene is Involved, According to OMIM, UniProtKB, Novoseek, PharmGKB, Genatlas, GeneTests, Blood group antigen gene mutations by BGMUT, HGMD, GAD, HuGE Navigator, BCGD, and/or TGDB.)
About This Section

OMIM: 109691 disorders: 601665

10/40 Novoseek disease relationships for ADRB3 gene (see all 40 )

Disease	Score	Articles	PubMed IDs for Articles with Shared Sentences (# sentences)
obesity	79.67	183	12709137 (4), 10480620 (4), 15061987 (3), 11093283 (3) (see all 99)
insulin resistance	75.11	88	9405912 (3), 10707554 (3), 8954053 (3), 11532330 (3) (see all 55)
niddm	71.02	72	10414939 (2), 18249219 (2), 7609751 (2), 8954053 (2) (see all 43)
overactive bladder	51.19	8	12007519 (2), 17600372 (1), 17011390 (1), 17626794 (1)
insulin sensitivity	51.00	12	8690160 (2), 9313101 (2), 10707551 (1), 15472194 (1) (see all 8)
impaired glucose tolerance	48.41	4	9313101 (1), 9828912 (1), 18249219 (1), 14506613 (1)
obesity morbid	46.62	7	8968849 (2), 7609752 (2), 8968850 (1), 9416435 (1) (see all 5)
metabolic disorder	44.85	6	11798745 (1), 16209345 (1), 15523499 (1), 16276096 (1) (see all 5)
hyperlipidemia familial combined	44.00	1	12370850 (1)
genetic susceptibility	42.97	7	17998022 (1), 9480495 (1), 10421979 (1), 15743038 (1) (see all 6)

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Genatlas disease: ADRB3

excess capacity to gain weight in patients with insulin resistance,early onset non insulin

dependent diabetes and/or morbid obesity,with fatty liver

Human Gene Mutation Database: ADRB3
Genetic Association Database: ADRB3
Human Genome Epidemiology Navigator: ADRB3 (180 documents)

(Possibly Related Articles in Doctor's Guide)
About This Section

(in PubMed. Associations of this gene to articles via ¹Novoseek, ²HGNC, ³Entrez Gene, ⁴UniProtKB/Swiss-Prot, ⁵UniProtKB/TrEMBL, ⁶GAD, and/or ⁷PharmGKB)
About This Section

10/445 PubMed articles for ADRB3 gene (see all 445 ):

Association of Trp64Arg mutation of the beta3-adrenergic-receptor with NIDDM and body weight gain. (PubMed id 8721782)^{1, 3, 4, 6} Fujisawa T.... Ogihara T. (1996)
The promoter and intron/exon structure of the human and mouse beta 3- adrenergic-receptor genes. (PubMed id 8389293)^{1, 3, 4} van Spronsen A.... Emorine L.J. (1993)
Association of cholecystokinin 1 receptor and beta3-adrenergic receptor polymorphisms with midlife weight gain. (PubMed id 15340101)^{1, 3, 6} Koda M....Funakoshi A. (2004)
[Common variants in beta 3-adrenergic-receptor and uncoupling protein-2 genes are associated with type 2 diabetes and obesity] (PubMed id 15061987)^{1, 3, 6} Xiu L.L....Huang Z.M. (2004)
Aldehyde dehydrogenase 2 and beta3-adrenergic receptor gene polymorphisms: their association with elevated liver enzymes and metabolic syndrome. (PubMed id 14506613)^{1, 3, 6} Murata C....Okazaki I. (2003)
Beta(3)-adrenergic receptor gene variant is associated with upper body obesity only in obese Japanese-American men but not in women. (PubMed id 11532330)^{1, 3, 6} Kawamura T....Okubo M. (2001)
Association of GYS1 and beta(3)-AR gene with postprandial hyperglycemia and serum uric acid in type 2 diabetes mellitus. (PubMed id 12411100)^{1, 3, 6} Wang G....Xu X. (2002)
[The effects of aerobic exercise on hormones, blood lipids and body composition in middle-aged obese women according to beta 3-adrenergic receptor gene polymorphisms] (PubMed id 15613846)^{1, 3, 6} Kim I.H. (2004)
[Mutation of beta 3-adrenergic-receptor gene and the response to dietary intervention in obese children] (PubMed id 12561621)^{1, 3, 6} Wang X....Wang Y. (2001)
Synergistic effect of polymorphisms of uncoupling protein 1 and beta3-adrenergic receptor genes on autonomic nervous system activity. (PubMed id 11439286)^{1, 3, 6} Shihara N....Tsuda K. (2001)

(in PubMed, OMIM, and NCBI Bookshelf)
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		AND	OR
Aliases
Free Text

Query String		PubMed OMIM NCBI Bookshelf
	(Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, and/or H-InvDB)
About This Section

Entrez Gene: 155	HGNC: 288	AceView: ADRB3	Ensembl:ENSG00000188778	euGenes: HUgn155
ECgene: ADRB3	H-InvDB: ADRB3

(According to HUGE)
About This Section

(According to ATLAS, HORDE, IMGT, MTDB, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section

Name	Description
SeattleSNPs	http://pga.gs.washington.edu/data/adrb3/

Licensable Technologies for ADRB3
(Available from WIS Yeda, Salk, Tufts)

About This Section

(Reagents available from Applied Biosystems, Antibodies and assays by Cell Signaling Technology, Abcam, Novus Biologicals,
Sigma-Aldrich, R&D Systems, Millipore, Abnova, and/or Invitrogen, Clones available from OriGene,and/or Invitrogen, Drugs and/or compounds by Sigma-Aldrich,
Enzo Life Sciences, and/or Tocris Bioscience)
About This Section

Products for ADRB3:

TaqMan ® Gene Expression Assays

TaqMan ® Genotyping Assays

Free SNP selection tool

Invitrogen iPath Pathways	Invitrogen BLOCK-iT™ RNAi
Invitrogen Antibodies	Invitrogen Assays
Invitrogen Clones	Invitrogen Q-PCR Products
Invitrogen Human Recombinant Kinases	Invitrogen Custom Antibody and Peptide Service
Invitrogen Proteins / Assays / Screening Services	Search Invitrogen catalog for ADRB3-related products

	Millipore Custom Antibody & Bulk Services
	Millipore Preclinical / Clinical Development Services
	Millipore Immunoassay Services
	Millipore Target Screening & Profiling Services

	Predesigned and custom siRNAs for ADRB3		Antibodies for ADRB3
	Explore super-pooled esiRNAs		Proteins for ADRB3
	Lentivirus-delivered shRNAs for ADRB3		Small molecules for ADRB3
	"Your Favorite Gene" Pathways		feedback

	Antibodies		Primer Pairs
	Cell Culture Products		ELISAs
	Flow Cytometry Kits		Protease Activity Assays & Reagents
	Cell Selection/Detection Kits & Reagents		ELISA/Assay Development Kits & Reagents
	Multiplex/Array Assay Kits & Reagents		ELISpot Kits & Development Modules
	Recombinant & Natural Proteins

	Recombinant Proteins (ADRB3)
	Antibodies (ADRB3)
	Chimera RNAi (ADRB3)
	Custom Service for Mouse Mab
	Custom Service for Rabbit Pab from Full-length Protein

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	Recombinant Proteins (beta 3 Adrenergic Receptor)
	Antibodies (beta 3 Adrenergic Receptor)

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ADRB3 Gene

protein-coding GIFtS: 66

Aliases &
Descriptions
for ADRB3

Summaries
for ADRB3

Genomic Location
for ADRB3

Proteins
for ADRB3

Protein Domains/
Families
for ADRB3

Gene Function
for ADRB3

Pathways & Interactions
for ADRB3

Drugs & Compounds
for ADRB3

Transcripts
for ADRB3

Expression
for ADRB3

Orthologs
for ADRB3

Paralogs
for ADRB3

SNPs/Variants
for ADRB3

Disorders & Mutations
for ADRB3

Medical News
for ADRB3

Publications
for ADRB3

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Genome Databases showing ADRB3

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for ADRB3

Services
for ADRB3

Gene Index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

ADRB3 Gene

protein-coding GIFtS: 66

Aliases & Descriptionsfor ADRB3

Summariesfor ADRB3

Genomic Locationfor ADRB3

Proteinsfor ADRB3

Protein Domains/Familiesfor ADRB3

Gene Functionfor ADRB3

Pathways & Interactionsfor ADRB3

Drugs & Compoundsfor ADRB3

Transcriptsfor ADRB3

Expression for ADRB3

Orthologsfor ADRB3

Paralogsfor ADRB3

SNPs/Variantsfor ADRB3

Disorders & Mutationsfor ADRB3

Medical Newsfor ADRB3

Publicationsfor ADRB3

Search for ADRB3

Genome Databases showing ADRB3

Other Databases showing ADRB3

Specialized Databases showing ADRB3

Licensable Technologiesfor ADRB3

Servicesfor ADRB3

Gene Index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

Aliases &
Descriptions
for ADRB3

Summaries
for ADRB3

Genomic Location
for ADRB3

Proteins
for ADRB3

Protein Domains/
Families
for ADRB3

Gene Function
for ADRB3

Pathways & Interactions
for ADRB3

Drugs & Compounds
for ADRB3

Transcripts
for ADRB3

Expression
for ADRB3

Orthologs
for ADRB3

Paralogs
for ADRB3

SNPs/Variants
for ADRB3

Disorders & Mutations
for ADRB3

Medical News
for ADRB3

Publications
for ADRB3

Licensable Technologies
for ADRB3

Services
for ADRB3