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Aliases for ADRB3 Gene

Aliases for ADRB3 Gene

  • Adrenoceptor Beta 3 2 3 5
  • Adrenergic, Beta-3-, Receptor 2 3
  • Beta-3 Adrenoreceptor 3 4
  • Beta-3 Adrenoceptor 3 4
  • BETA3AR 3
  • ADRB3R 4
  • B3AR 4

External Ids for ADRB3 Gene

Previous GeneCards Identifiers for ADRB3 Gene

  • GC08P037473
  • GC08M038084
  • GC08M9E0062
  • GC08M037939
  • GC08M037822
  • GC08M036354

Summaries for ADRB3 Gene

Entrez Gene Summary for ADRB3 Gene

  • The protein encoded by this gene belongs to the family of beta adrenergic receptors, which mediate catecholamine-induced activation of adenylate cyclase through the action of G proteins. This receptor is located mainly in the adipose tissue and is involved in the regulation of lipolysis and thermogenesis. [provided by RefSeq, Feb 2009]

GeneCards Summary for ADRB3 Gene

ADRB3 (Adrenoceptor Beta 3) is a Protein Coding gene. Diseases associated with ADRB3 include Obesity and Morbid Obesity. Among its related pathways are Peptide ligand-binding receptors and Myometrial Relaxation and Contraction Pathways. GO annotations related to this gene include G-protein coupled receptor activity and epinephrine binding. An important paralog of this gene is TAAR9.

UniProtKB/Swiss-Prot for ADRB3 Gene

  • Beta-adrenergic receptors mediate the catecholamine-induced activation of adenylate cyclase through the action of G proteins. Beta-3 is involved in the regulation of lipolysis and thermogenesis.

Tocris Summary for ADRB3 Gene

  • The adrenergic beta3 receptor (beta3-adrenoceptor) is a member of the adrenergic receptor group of G-protein-coupled receptors that also includes alpha1A, alpha1B, alpha1D, alpha2A, alpha2B, alpha2C, beta1 and beta2. They are located primarily in the small intestine, adipose tissue and vascular endothelium.

Gene Wiki entry for ADRB3 Gene

No data available for PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ADRB3 Gene

Genomics for ADRB3 Gene

Regulatory Elements for ADRB3 Gene

Enhancers for ADRB3 Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around ADRB3 on UCSC Golden Path with GeneCards custom track

Genomic Location for ADRB3 Gene

Chromosome:
8
Start:
37,962,991 bp from pter
End:
37,966,965 bp from pter
Size:
3,975 bases
Orientation:
Minus strand

Genomic View for ADRB3 Gene

Genes around ADRB3 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ADRB3 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ADRB3 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ADRB3 Gene

Proteins for ADRB3 Gene

  • Protein details for ADRB3 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P13945-ADRB3_HUMAN
    Recommended name:
    Beta-3 adrenergic receptor
    Protein Accession:
    P13945
    Secondary Accessions:
    • Q4JFT4

    Protein attributes for ADRB3 Gene

    Size:
    408 amino acids
    Molecular mass:
    43519 Da
    Quaternary structure:
    • Interacts with ARRDC3.

    Three dimensional structures from OCA and Proteopedia for ADRB3 Gene

neXtProt entry for ADRB3 Gene

Proteomics data for ADRB3 Gene at MOPED

Post-translational modifications for ADRB3 Gene

  • Glycosylation at Asn 8 and Asn 26
  • Modification sites at PhosphoSitePlus

Other Protein References for ADRB3 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for ADRB3 Gene

Domains & Families for ADRB3 Gene

Gene Families for ADRB3 Gene

Graphical View of Domain Structure for InterPro Entry

P13945

UniProtKB/Swiss-Prot:

ADRB3_HUMAN :
  • Belongs to the G-protein coupled receptor 1 family. Adrenergic receptor subfamily. ADRB3 sub-subfamily.
Family:
  • Belongs to the G-protein coupled receptor 1 family. Adrenergic receptor subfamily. ADRB3 sub-subfamily.
genes like me logo Genes that share domains with ADRB3: view

Function for ADRB3 Gene

Molecular function for ADRB3 Gene

GENATLAS Biochemistry:
adrenergic,beta-3-,receptor,G protein coupled receptor superfamily,mostly expressed in brown and white adipose tissue,activating adenylate cyclase,susceptibility gene for hypertension in the Sardinian population (polymorphism W64R) and for obesity in Mexican-American population
UniProtKB/Swiss-Prot Function:
Beta-adrenergic receptors mediate the catecholamine-induced activation of adenylate cyclase through the action of G proteins. Beta-3 is involved in the regulation of lipolysis and thermogenesis.
genes like me logo Genes that share phenotypes with ADRB3: view

Animal Models for ADRB3 Gene

MGI Knock Outs for ADRB3:

Animal Model Products

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for ADRB3 Gene

Localization for ADRB3 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ADRB3 Gene

Cell membrane; Multi-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for ADRB3 Gene COMPARTMENTS Subcellular localization image for ADRB3 gene
Compartment Confidence
plasma membrane 5
nucleus 3
mitochondrion 2
cytosol 1
extracellular 1

Gene Ontology (GO) - Cellular Components for ADRB3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0016020 membrane IEA --
genes like me logo Genes that share ontologies with ADRB3: view

Pathways & Interactions for ADRB3 Gene

genes like me logo Genes that share pathways with ADRB3: view

Gene Ontology (GO) - Biological Process for ADRB3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0002024 diet induced thermogenesis IEA --
GO:0002025 vasodilation by norepinephrine-epinephrine involved in regulation of systemic arterial blood pressure IBA --
GO:0006091 generation of precursor metabolites and energy TAS 2570461
GO:0006112 energy reserve metabolic process TAS 1718744
GO:0006898 NOT receptor-mediated endocytosis IDA 15123695
genes like me logo Genes that share ontologies with ADRB3: view

No data available for SIGNOR curated interactions for ADRB3 Gene

Drugs & Compounds for ADRB3 Gene

(69) Drugs for ADRB3 Gene - From: DrugBank, PharmGKB, ApexBio, DGIdb, IUPHAR, HMDB, Tocris, and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Bupranolol Approved Pharma Antagonist, Target, antagonist 0
Isoproterenol Approved Pharma Full agonist, Agonist, Target, agonist 20
Propranolol Approved, Investigational Pharma Antagonist, antagonist, Target 207
Nadolol Approved Pharma Antagonist, antagonist 21
Norepinephrine Approved Pharma Target, agonist 654

(19) Additional Compounds for ADRB3 Gene - From: Novoseek, IUPHAR, and Tocris

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
(plusmn)-adrenaline
Partial agonist, Agonist
SR58611A
Full agonist, Agonist
(S)-(-)-Pindolol
26328-11-0
BRL 37344, sodium salt
127299-93-8
ICI 215,001 hydrochloride
140850-02-8

(5) Tocris Compounds for ADRB3 Gene

Compound Action Cas Number
(S)-(-)-Pindolol beta3 partial agonist. More active enantiomer of pindolol (Cat. No. 0994) 26328-11-0
BRL 37344, sodium salt beta3 agonist 127299-93-8
ICI 215,001 hydrochloride beta3 agonist 140850-02-8
Pindolol beta3 partial agonist 13523-86-9
ZD 7114 hydrochloride beta3 agonist 129689-28-7

(2) ApexBio Compounds for ADRB3 Gene

Compound Action Cas Number
Esmolol HCl 81161-17-3
Sotalol hydrochloride β-adrenergic receptor antagonist 959-24-0
genes like me logo Genes that share compounds with ADRB3: view

Drug Products

Transcripts for ADRB3 Gene

mRNA/cDNA for ADRB3 Gene

Unigene Clusters for ADRB3 Gene

Adrenoceptor beta 3:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for ADRB3 Gene

No ASD Table

Relevant External Links for ADRB3 Gene

GeneLoc Exon Structure for
ADRB3
ECgene alternative splicing isoforms for
ADRB3

Expression for ADRB3 Gene

mRNA expression in normal human tissues for ADRB3 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for ADRB3 Gene

This gene is overexpressed in Ovary (x14.6), Fallopian Tube (x6.9), Esophagus - Muscularis (x6.5), Bladder (x5.9), and Esophagus - Gastroesophageal Junction (x4.4).

SOURCE GeneReport for Unigene cluster for ADRB3 Gene Hs.2549

mRNA Expression by UniProt/SwissProt for ADRB3 Gene

P13945-ADRB3_HUMAN
Tissue specificity: Expressed mainly in adipose tissues.
genes like me logo Genes that share expression patterns with ADRB3: view

Primer Products

No data available for Protein differential expression in normal tissues , Protein expression and Protein tissue co-expression partners for ADRB3 Gene

Orthologs for ADRB3 Gene

This gene was present in the common ancestor of animals.

Orthologs for ADRB3 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia ADRB3 35
  • 86.91 (n)
  • 86.17 (a)
ADRB3 36
  • 86 (a)
OneToOne
dog
(Canis familiaris)
Mammalia ADRB3 35
  • 86.37 (n)
  • 83.29 (a)
ADRB3 36
  • 83 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Adrb3 35
  • 81.33 (n)
  • 81.84 (a)
Adrb3 16
Adrb3 36
  • 81 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia ADRB3 35
  • 99.02 (n)
  • 98.28 (a)
ADRB3 36
  • 98 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Adrb3 35
  • 80.9 (n)
  • 81.33 (a)
oppossum
(Monodelphis domestica)
Mammalia ADRB3 36
  • 77 (a)
OneToOne
chicken
(Gallus gallus)
Aves LOC430991 35
  • 71.31 (n)
  • 67.25 (a)
ADRB3 36
  • 45 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia ADRB3 36
  • 46 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia LOC100487086 35
  • 61.81 (n)
  • 62.15 (a)
zebrafish
(Danio rerio)
Actinopterygii adrb3a 35
  • 56.57 (n)
  • 57.24 (a)
adrb3a 36
  • 41 (a)
OneToMany
adrb3b 36
  • 39 (a)
OneToMany
fruit fly
(Drosophila melanogaster)
Insecta CG6919 37
  • 36 (a)
CG6989 37
  • 37 (a)
CG7431 37
  • 40 (a)
DopR 37
  • 34 (a)
oa2 36
  • 23 (a)
ManyToMany
Octbeta2R 36
  • 23 (a)
ManyToMany
worm
(Caenorhabditis elegans)
Secernentea M03F4.3 37
  • 39 (a)
Species with no ortholog for ADRB3:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for ADRB3 Gene

ENSEMBL:
Gene Tree for ADRB3 (if available)
TreeFam:
Gene Tree for ADRB3 (if available)

Paralogs for ADRB3 Gene

Paralogs for ADRB3 Gene

genes like me logo Genes that share paralogs with ADRB3: view

Variants for ADRB3 Gene

Polymorphic Variants from UniProtKB/Swiss-Prot for ADRB3 Gene

ADRB3_HUMAN-P13945
The variant Arg-64 seems to be associated with weight gain (obesity) and is also associated with susceptibility to non-insulin-dependent diabetes mellitus (NIDDM).

Sequence variations from dbSNP and Humsavar for ADRB3 Gene

SNP ID Clin Chr 08 pos Sequence Context AA Info Type
rs4994 - 37,966,280(-) TCGCC(C/T)GGACT reference, missense
rs4995 - 37,965,676(-) GGGGA(C/G/T)GTGCG reference, missense
rs36031925 - 37,965,413(-) ACTTT(C/G/T)GCAGC reference, missense
rs28364012 - 37,965,725(-) CCGAG(A/G)AGTCT reference, missense
rs2071493 -- 37,964,335(-) AACTA(A/G)ATATG intron-variant

Structural Variations from Database of Genomic Variants (DGV) for ADRB3 Gene

Variant ID Type Subtype PubMed ID
nsv890719 CNV Loss 21882294

Variation tolerance for ADRB3 Gene

Gene Damage Index Score: 5.83; 73.88% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for ADRB3 Gene

Human Gene Mutation Database (HGMD)
ADRB3

Disorders for ADRB3 Gene

MalaCards: The human disease database

(11) MalaCards diseases for ADRB3 Gene - From: OMIM, ClinVar, DISEASES, Novoseek, and GeneCards

Disorder Aliases PubMed IDs
obesity
  • obesity, association with
morbid obesity
  • severe obesity
low compliance bladder
  • hyperactivity of bladder
glucose intolerance
  • fatty stool
hyperuricemia
  • uricacidemia
- elite association - COSMIC cancer census association via MalaCards
Search ADRB3 in MalaCards View complete list of genes associated with diseases

Genatlas disease for ADRB3 Gene

excess capacity to gain weight in patients with insulin resistance,early onset non insulin dependent diabetes and/or morbid obesity,with fatty liver

Relevant External Links for ADRB3

Genetic Association Database (GAD)
ADRB3
Human Genome Epidemiology (HuGE) Navigator
ADRB3
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
ADRB3
genes like me logo Genes that share disorders with ADRB3: view

No data available for UniProtKB/Swiss-Prot for ADRB3 Gene

Publications for ADRB3 Gene

  1. Association of Trp64Arg mutation of the beta3-adrenergic-receptor with NIDDM and body weight gain. (PMID: 8721782) Fujisawa T. … Ogihara T. (Diabetologia 1996) 3 4 48 67
  2. Beta 3 adrenergic receptors: molecular, histological, functional and pharmacological approaches. (PMID: 19434307) Coman O.A. … Fulga I. (Rom J Morphol Embryol 2009) 23 25 26
  3. In vivo beta3-adrenergic stimulation of human thermogenesis and lipid use. (PMID: 10824635) Schiffelers S.L. … van Baak M.A. (Clin. Pharmacol. Ther. 2000) 23 25 26
  4. [Specific stimulation of adipose tissue adrenergic beta 3 receptors by octopamine]. (PMID: 8106131) Galitzky J. … Berlan M. (C. R. Acad. Sci. III, Sci. Vie 1993) 23 25 26
  5. Trp64Arg polymorphism of the ADRB3 gene predicts hyperuricemia risk in a population from southern Spain. (PMID: 20008926) Morcillo S. … Soriguer F. (J. Rheumatol. 2010) 3 23

Products for ADRB3 Gene

Sources for ADRB3 Gene

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