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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

ADRB3 Gene

protein-coding   GIFtS: 66
GCID: GC08M037822

Adrenoceptor Beta 3

(Previous names: adrenergic, beta-3-, receptor)
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(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
Adrenoceptor Beta 31 2     BETA3AR2
Adrenergic, Beta-3-, Receptor1 2     Beta-3 Adrenergic Receptor2
Beta-3 Adrenoceptor2 3     ADRB3R3
Beta-3 Adrenoreceptor2 3     B3AR3

External Ids:    HGNC: 2881   Entrez Gene: 1552   Ensembl: ENSG000001887787   OMIM: 1096915   UniProtKB: P139453   

Export aliases for ADRB3 gene to outside databases

Previous GC identifers: GC08P037473 GC08M038084 GC08M9E0062 GC08M037939 GC08M036354


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for ADRB3 Gene:
The protein encoded by this gene belongs to the family of beta adrenergic receptors, which mediate
catecholamine-induced activation of adenylate cyclase through the action of G proteins. This receptor is located
mainly in the adipose tissue and is involved in the regulation of lipolysis and thermogenesis. (provided by
RefSeq, Feb 2009)

GeneCards Summary for ADRB3 Gene: 
ADRB3 (adrenoceptor beta 3) is a protein-coding gene. Diseases associated with ADRB3 include obesity, variation in, and morbid obesity, and among its related super-pathways are Class A/1 (Rhodopsin-like receptors) and Amine ligand-binding receptors. GO annotations related to this gene include protein homodimerization activity and norepinephrine binding. An important paralog of this gene is TAAR6.

UniProtKB/Swiss-Prot: ADRB3_HUMAN, P13945
Function: Beta-adrenergic receptors mediate the catecholamine-induced activation of adenylate cyclase through the
action of G proteins. Beta-3 is involved in the regulation of lipolysis and thermogenesis

summary for ADRB3 Gene:
The adrenergic beta3 receptor (beta3-adrenoceptor) is a member of the adrenergic receptor group of
G-protein-coupled receptors that also includes alpha1A, alpha1B, alpha1D, alpha2A, alpha2B, alpha2C, beta1
and beta2. They are located primarily in the small intestine, adipose tissue and vascular endothelium where
they are involved in lipolysis, glucose uptake, cardio-inhibition and relaxation of colon, esophagus and
bladder. The human beta3 receptor gene has been localized to chromosome 8 (8p12-8p11.1).

Gene Wiki entry for ADRB3 (Beta-3 adrenergic receptor) Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000008.10  NC_018919.2  NT_167187.1  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the ADRB3 gene promoter:
         GR   STAT1   STAT4   GR-beta   STAT1beta   STAT5A   STAT1alpha   STAT2   STAT3   GR-alpha   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidADRB3 promoter sequence
   Search SABiosciences Chromatin IP Primers for ADRB3

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat ADRB3


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 8p12   Ensembl cytogenetic band:  8p11.23   HGNC cytogenetic band: 8p12

ADRB3 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
ADRB3 gene location

GeneLoc information about chromosome 8         GeneLoc Exon Structure

GeneLoc location for GC08M037822:  view genomic region     (about GC identifiers)

Start:
37,820,513 bp from pter      End:
37,824,483 bp from pter
Size:
3,971 bases      Orientation:
minus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: ADRB3_HUMAN, P13945 (See protein sequence)
Recommended Name: Beta-3 adrenergic receptor  
Size: 408 amino acids; 43519 Da
Subcellular location: Cell membrane; Multi-pass membrane protein
1 PDB 3D structure from and Proteopedia for ADRB3:
2CDW (3D)    
Secondary accessions: Q4JFT4

Explore the universe of human proteins at neXtProt for ADRB3: NX_P13945

Explore proteomics data for ADRB3 at MOPED 

ADRB3 Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

ADRB3 Protein Expression

REFSEQ proteins: NP_000016.1  
ENSEMBL proteins: 
 ENSP00000343782  
Reactome Protein details: P13945
Human Recombinant Protein Products for ADRB3: 
EMD Millipore Purified and/or Recombinant ADRB3 Protein
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GenScript Custom Purified and Recombinant Proteins Services for ADRB3
Novus Biologicals ADRB3 Proteins
Novus Biologicals ADRB3 Lysates
Browse Sino Biological Recombinant Proteins
Browse Sino Biological Cell Lysates 
Browse ProSpec Recombinant Proteins
Browse Proteins at Cloud-Clone Corp. 

Gene Ontology (GO): 5/6 cellular component terms (GO ID links to tree view) (see all 6):    About this table

GO IDQualified GO termEvidencePubMed IDs
GO:0005634nucleus IEA--
GO:0005886plasma membrane TAS--
GO:0005887integral to plasma membrane TAS1718744
GO:0016020membrane ----
GO:0016021integral to membrane ----

ADRB3 for ontologies           About GeneDecksing



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(According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section
HGNC Gene Families: 
ADRB: GPCR / Class A : Adrenoceptors : beta

IUPHAR Guide to PHARMACOLOGY protein family classification: β3-adrenoceptor 
Adrenoceptors

4 InterPro protein domains:
 IPR017452 GPCR_Rhodpsn_7TM
 IPR002233 Adrnrgc_rcpt
 IPR000681 Adrgc_rcpt_B3
 IPR000276 GPCR_Rhodpsn

Graphical View of Domain Structure for InterPro Entry P13945

ProtoNet protein and cluster: P13945

2 Blocks protein domains:
IPB000681 Beta-3 adrenergic receptor signature
IPB002233 Adrenergic receptor signature


UniProtKB/Swiss-Prot: ADRB3_HUMAN, P13945
Similarity: Belongs to the G-protein coupled receptor 1 family. Adrenergic receptor subfamily. ADRB3 sub-subfamily


ADRB3 for domains           About GeneDecksing


(According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
About This Section

Molecular Function:

     UniProtKB/Swiss-Prot Summary: ADRB3_HUMAN, P13945
Function: Beta-adrenergic receptors mediate the catecholamine-induced activation of adenylate cyclase through the
action of G proteins. Beta-3 is involved in the regulation of lipolysis and thermogenesis

     Genatlas biochemistry entry for ADRB3:
adrenergic,beta-3-,receptor,G protein coupled receptor superfamily,mostly expressed in brown and white adipose
tissue,activating adenylate cyclase,susceptibility gene for hypertension in the Sardinian population
(polymorphism W64R) and for obesity in Mexican-American population

     Gene Ontology (GO): 5/8 molecular function terms (GO ID links to tree view) (see all 8):    About this table

GO IDQualified GO termEvidencePubMed IDs
GO:0004930G-protein coupled receptor activity ----
GO:0004939beta-adrenergic receptor activity IDA15123695
GO:0005515protein binding IPI15123695
GO:0015052beta3-adrenergic receptor activity IMP9892244
GO:0031699beta-3 adrenergic receptor binding IEA--
     
ADRB3 for ontologies           About GeneDecksing


Phenotypes:
     5 MGI mutant phenotypes (inferred from 2 alleles(MGI details for Adrb3):
 adipose tissue  behavior/neurological  endocrine/exocrine gland  growth/size  homeostasis/metabolism 

ADRB3 for phenotypes           About GeneDecksing

Animal Models:
     MGI mouse knock-outs for ADRB3: Adrb3tm1Lowl Adrb3tm1Jpg

   inGenious Targeting Laboratory - Custom generated mouse model solutions for ADRB3 
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   genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for ADRB3 

miRNA
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8/20 QIAGEN miScript miRNA Assays for microRNAs that regulate ADRB3 (see all 20):
hsa-miR-4328 hsa-let-7d hsa-miR-202 hsa-let-7c hsa-miR-570 hsa-let-7g hsa-miR-641 hsa-let-7a
SwitchGear 3'UTR luciferase reporter plasmidADRB3 3' UTR sequence
Inhib. RNA
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GenScript: all cDNA clones in your preferred vector: ADRB3 (NM_000025)
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Cell Line
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In Situ Assay
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Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ADRB3


(Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
About This Section

SuperPaths for ADRB3 About   (see all 13)                                                                                              See pathways by source

SuperPathContained pathways About
1Class A/1 (Rhodopsin-like receptors)
Class A/1 (Rhodopsin-like receptors)0.71
GPCRs, Class A Rhodopsin-like0.41
GPCR ligand binding0.71
Neuroactive ligand-receptor interaction0.37
2Monoamine GPCRs
Monoamine GPCRs0.79
Amine ligand-binding receptors0.79
3PKA activation in glucagon signalling
Beta-2 adrenergic-dependent CFTR expression0.74
Development Beta-adrenergic receptors signaling via cAMP0.32
4Signaling by GPCR
Signaling by GPCR0.90
Signal Transduction0.55
GPCR downstream signaling0.90
5Activation of cAMP-Dependent PKA
Activation of cAMP-Dependent PKA0.77
Activation of PKA through GPCR0.71
cAMP Pathway0.77

Pathways by source                                                                                                                                                                 See SuperPaths
Show all pathways

4 EMD Millipore Pathways for ADRB3
    Development Beta-adrenergic receptors regulation of ERK
Development Beta-adrenergic receptors signaling via cAMP
Transcription CREB pathway
Development Ligand-independent activation of ESR1 and ESR2

3 Downloadable PowerPoint Slides of QIAGEN Pathway Central Maps for ADRB3
    Activation of PKA through GPCR
cAMP Pathway
Activation of cAMP-Dependent PKA

5 GeneGo (Thomson Reuters) Pathways for ADRB3
    Development Ligand-independent activation of ESR1 and ESR2
Development Beta-adrenergic receptors signaling via cAMP
Beta-2 adrenergic-dependent CFTR expression
Transcription CREB pathway
Development Beta-adrenergic receptors regulation of ERK

3 BioSystems Pathways for ADRB3
    Calcium Regulation in the Cardiac Cell
GPCRs, Class A Rhodopsin-like
Monoamine GPCRs

5/8        Reactome Pathways for ADRB3 (see all 8)
    GPCR downstream signaling
Signaling by GPCR
GPCR ligand binding
Adrenoceptors
Class A/1 (Rhodopsin-like receptors)


4         Kegg Pathways  (Kegg details for ADRB3):
    Calcium signaling pathway
Neuroactive ligand-receptor interaction
Endocytosis
Salivary secretion


ADRB3 for pathways           About GeneDecksing

Interactions:

    SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for ADRB3

STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

5/75 Interacting proteins for ADRB3 (P139453 ENSP000003437824) via UniProtKB, MINT, STRING, and/or I2D (see all 75)
InteractantInteraction Details
GeneCardExternal ID(s)
ADRB2P075503, ENSP000003053724I2D: score=1 STRING: ENSP00000305372
GNASQ5JWF23, ENSP000003601414I2D: score=1 STRING: ENSP00000360141
SRCP129313, ENSP000003509414I2D: score=2 STRING: ENSP00000350941
ADCY2ENSP000003429524STRING: ENSP00000342952
ADRB1ENSP000003583014STRING: ENSP00000358301
About this table

Gene Ontology (GO): 5/20 biological process terms (GO ID links to tree view) (see all 20):    About this table

GO IDQualified GO termEvidencePubMed IDs
GO:0002024diet induced thermogenesis IEA--
GO:0002025vasodilation by norepinephrine-epinephrine involved in regulation of systemic arterial blood pressure IEA--
GO:0002032NOT desensitization of G-protein coupled receptor protein signaling pathway by arrestin IDA15123695
GO:0005975carbohydrate metabolic process TAS2570461
GO:0006091generation of precursor metabolites and energy TAS2570461

ADRB3 for ontologies           About GeneDecksing



(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
About This Section

ADRB3 for compounds           About GeneDecksing

Browse Small Molecules at EMD Millipore
Browse drugs & compounds from Enzo Life Sciences

Compounds for ADRB3 available from Tocris Bioscience    About this table
CompoundAction CAS #
BRL 37344, sodium salt beta3 agonist[127299-93-8]
L-748,337 Selective beta3 antagonist[244192-94-7]
SR 59230A hydrochloridePotent and selective beta3 antagonist[1135278-41-9]
CL 316243 disodium saltHighly selective beta3 agonist[151126-84-0]
SR 58611A hydrochloridebeta3 agonist; displays anxiolytic and antidepressant effects[121524-09-2]

2 HMDB Compounds for ADRB3    About this table
CompoundSynonyms CAS #PubMed Ids
Norepinephrine(-)-(R)-Norepinephrine (see all 32)51-41-2--
PropranololDociton (see all 8)525-66-6--

10/11 DrugBank Compounds for ADRB3 (see all 11)    About this table
CompoundSynonyms CAS #TypeActionsPubMed Ids
NorepinephrineArterenol (see all 4)51-41-2targetagonist8105356 8097243 9464897 17139284 17016423 8106131
DroxidopaDroxydopa (see all 4)23651-95-8targetagonist18064417 9464897 19110970 19434307
BupranololBupranol (see all 2)23284-25-5targetantagonist14660028 12606631
IsoproterenolEpinephrine Isopropyl Homolog (see all 14)7683-59-2targetagonist10722 10824635
PropranololDl-Propranolol Hydrochloride (see all 7)525-66-6targetantagonist20231523 11752352
Arbutamine-- 128470-16-6targetagonist8723169
Bopindolol-- 69010-88-4target--11752352
Clenbuterol-- 37148-27-9targetagonist20590599
EphedraChinese jointfir (see all 3)--targetagonist10449190
FenoterolFenoterolum [inn-latin] (see all 2)13392-18-2targetagonist14730417

10/22 IUPHAR Ligands for ADRB33-adrenoceptor) (see all 22)    About this table 
LigandTypeActionAffinityPubmed IDs
L 755507
AgonistFull agonist10.120590599
[125I]ICYP
AgonistPartial agonist9.2 - 9.89131260 9117106 8982677 10079020 14744619
carvedilol
AntagonistAntagonist9.410411574
L742791
AgonistAgonist8.89873496
carazolol
AgonistFull agonist8.78719421
tertatolol
AntagonistAntagonist8.614744619
L-748337
AntagonistAntagonist8.410411574
SR59230A
AntagonistAntagonist6.9 - 8.410411574 8730727 14730417
CGP 12177
AgonistPartial agonist6.1 - 7.38719421 7903415 9117106 10079020
bupranolol
AntagonistAntagonist6.8 - 7.310411574 8719421 7903415 10079020

10/41 Novoseek inferred chemical compound relationships for ADRB3 gene (see all 41)    About this table
Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
brl37344 84.5 7 10188996 (1), 17067575 (1), 12670949 (1), 10411574 (1) (see all 5)
cgp 12177 78.8 4 10800773 (1), 18704193 (1)
bupranolol 67.7 7 12909312 (1), 17626794 (1), 7601122 (1), 9915482 (1) (see all 5)
isoproterenol 61.9 14 10824635 (2), 9607772 (2), 18704193 (2), 10188996 (1) (see all 9)
benzenesulfonamide 61.9 3 9871716 (1), 11055339 (1), 10999482 (1)
glucose 58.1 61 9828912 (4), 9826220 (3), 9845761 (3), 9313101 (2) (see all 35)
nadolol 47.9 5 10824635 (1), 12909312 (1), 18704193 (1)
lipid 45.1 49 18482921 (4), 12370850 (3), 9845761 (3), 11003049 (3) (see all 31)
procaterol 40.6 1 10188996 (1)
arginine 40.1 17 8690160 (1), 9133593 (1), 9426386 (1), 12561621 (1) (see all 14)

1 PharmGKB related drug/compound annotation for ADRB3 gene    About this table
Drug/compound PharmGKB Annotation
olanzapineCA  

Search CenterWatch for drugs/clinical trials and news about ADRB3

(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from EMD Millipore,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
About This Section

REFSEQ mRNAs for ADRB3 gene: 
NM_000025.2  

Unigene Cluster for ADRB3:

Adrenoceptor beta 3
Hs.2549  [show with all ESTs]
Unigene Representative Sequence: NM_000025
2 Ensembl transcripts including schematic representations, and UCSC links where relevant:
ENST00000345060(uc003xkr.2) ENST00000520341

miRNA
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SwitchGear 3'UTR luciferase reporter plasmidADRB3 3' UTR sequence
Inhib. RNA
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Browse for Gene Knock-down Tools from EMD Millipore
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Clone
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OriGene clones in human, mouse for ADRB3 (see all 6)
OriGene ORF clones in mouse, rat for ADRB3
OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
GenScript: all cDNA clones in your preferred vector: ADRB3 (NM_000025)
DNA2.0 Custom Codon Optimized Gene Synthesis Service for ADRB3
Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat ADRB3
Sirion Biotech Customized lentivirus for stable overexpression of ADRB3 
                     Customized lentivirus expression plasmids for stable overexpression of ADRB3 
Primer
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OriGene qPCR primer pairs and template standards for ADRB3
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  QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat ADRB3
  QIAGEN QuantiFast Probe-based Assays in human, mouse, rat ADRB3

Additional mRNA sequence: 

AK293033.1 AK313857.1 AY487247.1 BC075017.2 S53291.1 X70811.1 

2 DOTS entries:

DT.455704  DT.100741406 

24/28 AceView cDNA sequences (see all 28):

BC075017 AY487247 NM_000025 BM728296 X70811 AL553958 S53291 AL553957 
AL550996 AI276134 BV183211 BM543956 BV198897 BV194193 BV198898 BV198900 
BV194192 BX281822 BV198899 AL550664 AL574813 BM546330 BP381136 BQ024407 

GeneLoc Exon Structure


(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section

ADRB3 expression in normal human tissues (normalized intensities)      ADRB3 embryonic expression: see
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS <intensity>2/3
CGAP TAG: GTGTGTGTGT
ADRB3 Expression
About this image


ADRB3 expression in embryonic tissues and stem cells    About this table
Data from LifeMap, the Embryonic Development and Stem Cells Database 
 5/3 selected tissues (see all 3) fully expand
 
 Adipose (Muscoskeletal System)    fully expand to see all 4 entries
         Body Subcutaneous White Adipose
         epididymal fat pads   
 
 Breast (Uncategorized)
         mammary gland   
 
 Gonad (Reproductive System)
         Primordial Germ Cells Primitive Gonad

See ADRB3 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for ADRB3

SOURCE GeneReport for Unigene cluster: Hs.2549

UniProtKB/Swiss-Prot: ADRB3_HUMAN, P13945
Tissue specificity: Expressed mainly in adipose tissues

    SABiosciences Expression via Pathway-Focused PCR Arrays including ADRB3: 
          Neurotransmitter Receptors in human mouse rat
          Insulin Signaling Pathway in human mouse rat
          G Protein Coupled Receptors 384HT in human mouse rat
          Diabetes in human mouse rat

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(Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
About This Section

This gene was present in the common ancestor of animals.

Orthologs for ADRB3 gene from 5/11 species (see all 11)    About this table
Organism Taxonomic
classification
Gene Description Human
Similarity
Orthology
Type
Details
mouse
(Mus musculus)
Mammalia Adrb31 , 5 adrenergic receptor, beta 31, 5 82.64(n)1
84.11(a)1
  8 (15.94 cM)5
115561  NM_013462.31  NP_038490.21 
 272257765 
chicken
(Gallus gallus)
Aves ADRB16
Uncharacterized protein
43(a)
1 ↔ 1
22(2237794-2240084)
lizard
(Anolis carolinensis)
Reptilia ADRB36
Uncharacterized protein
45(a)
1 ↔ 1
GL343406.1(536199-540859)
zebrafish
(Danio rerio)
Actinopterygii adrb3a1 adrenergic receptor, beta 3a 57.5(n)
56.63(a)
  558248  NM_001128335.1  NP_001121807.1 
fruit fly
(Drosophila melanogaster)
Insecta CG74313
TyrRII1
G-protein coupled receptor protein
signaling pathway more3
Tyramine receptor II1
40(a)
(best of 4)3
54.75(n)1
41.92(a)1
  421351  NM_142394.21  NP_650651.11 


ENSEMBL Gene Tree for ADRB3 (if available)
TreeFam Gene Tree for ADRB3 (if available)

(Paralogs according to 1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
Paralogs for ADRB3 gene
TAAR62  HTR62  TAAR22  ADRB12  ADRA1B2  TAAR92  TAAR82  HRH22  
DRD12  ADRB22  TAAR12  ADRA1A2  HTR42  DRD52  ADRA1D2  TAAR52  
15 SIMAP similar genes for ADRB3 using alignment to 4 protein entries:     ADRB3_HUMAN (see all proteins):
DRD2    ADRB2    hA2aR    ADRB1    ADRA1B    ADRA1A
HTR5A    ADRA1D    DRD5P1    alpha 1c-adrenoceptor subtype    DRD1    HTR1B
HRH2    HTR7    HTR6

ADRB3 for paralogs           About GeneDecksing



(SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section

UniProtKB/Swiss-Prot: ADRB3_HUMAN, P13945
Polymorphism: The variant Arg-64 seems to be associated with weight gain (obesity) and is also associated with
susceptibility to non-insulin-dependent diabetes mellitus (NIDDM)


10/330 SNPs in ADRB3 are shown (see all 330)    About this table     
Genomic DataTranscription Related DataAllele Frequencies
SNP IDValidClinical
significance
Chr 8 posSequence#AA
Chg
TypeMore#Allele
freq
PopTotal
sample
More
----------
rs49941,2,4
C,F,Hother138051172(-) TCGCCT/CGGACT 2 /R /W mis136Minor allele frequency- C:0.11MN EA NS NA WA CSA EU 9488
rs1875873101,2
--36360542(+) TCACCA/GTGTCC 1 -- us2k10--------
rs39904011,2
C--37820698(+) acaca-/CACCATG 1 -- ut310--------
rs101090281,2
C,F--37825153(+) agccaT/Ccgcgc 1 -- us2k12Minor allele frequency- C:0.01NS 94
rs132706561,2
C,F--37825156(+) caccgC/G/Tgcccg 1 -- us2k13NS CSA 95
rs96941971,2
C,F,H--38047467(+) CAGACA/GCCAGA 1 -- ds500126Minor allele frequency- G:0.21NS EA NA WA CSA 2434
rs1512775591,2
--38047515(+) CTTTGA/GTATGA 1 -- ds50010--------
rs1854043721,2
--38047722(+) TTACCA/GGGCAT 1 -- ds50010--------
rs1402642501,2
C--38047761(+) GGCTCA/GTAGAG 1 -- ds50010--------
rs346190571,2
C,F--38047804(-) TTCTAA/TGGAAA 1 -- ds50017Minor allele frequency- T:0.09NS NA WA EA 456

HapMap Linkage Disequilibrium report for ADRB3 (37820513 - 37824483 bp)

Structural Variations
     Database of Genomic Variants (DGV) 1 variation for ADRB3:    About this table     
Variant IDTypeSubtypePubMed ID
nsv890719CNV Loss21882294


Human Gene Mutation Database (HGMD): ADRB3
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(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
About This Section
OMIM gene information: 109691   
OMIM disorders: 601665  
20/64 diseases for ADRB3 (see all 64):    About MalaCards
obesity, variation in    morbid obesity    resting heart rate    glucose intolerance
hyperuricemia    diabetic ketoacidosis    acanthosis nigricans    gestational diabetes
nonalcoholic steatohepatitis    chorioamnionitis    familial combined hyperlipidemia    portal hypertension
fibromyalgia    cystitis    insulin resistance    lipodystrophy
essential hypertension    hyperglycemia    obesity, association with    bone density

2 diseases from the University of Copenhagen DISEASES database for ADRB3:
Diabetes mellitus     Hypertension

ADRB3 for disorders           About GeneDecksing


Congresses - knowledge worth sharing:  
Alzheimer's & Parkinson's Diseases Congress (ADPD) 18 - 22 March 2015

10/41 Novoseek inferred disease relationships for ADRB3 gene (see all 41)    About this table

Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
obesity 79 187 12709137 (4), 10480620 (4), 15061987 (3), 11093283 (3) (see all 99)
insulin resistance 74.1 90 9405912 (3), 10707554 (3), 8954053 (3), 11532330 (3) (see all 56)
niddm 69.8 74 10414939 (2), 18249219 (2), 10826514 (2), 7609750 (2) (see all 43)
overactive bladder 51.6 8 12007519 (2), 17600372 (1), 17011390 (1), 17626794 (1)
insulin sensitivity 49.2 12 8690160 (2), 9313101 (2), 10707551 (1), 15472194 (1) (see all 8)
impaired glucose tolerance 46.9 4 9313101 (1), 9828912 (1), 18249219 (1), 14506613 (1)
obesity morbid 44.8 7 8968849 (2), 7609752 (2), 8968850 (1), 9416435 (1) (see all 5)
genetic susceptibility 44.8 7 17998022 (1), 9480495 (1), 10421979 (1), 15743038 (1) (see all 6)
hyperlipidemia familial combined 42.9 1 12370850 (1)
metabolic disorder 42.7 6 11798745 (1), 16209345 (1), 15523499 (1), 16276096 (1) (see all 5)

Genatlas disease: ADRB3
excess capacity to gain weight in patients with insulin resistance,early onset non insulin dependent diabetes
and/or morbid obesity,with fatty liver

Genetic Association Database (GAD): ADRB3
Human Genome Epidemiology (HuGE) Navigator: ADRB3 (220 documents)

Export disorders for ADRB3 gene to outside databases

(in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
About This Section

PubMed articles for ADRB3 gene, integrated from 9 sources (see all 543):
(articles sorted by number of sources associating them with ADRB3)
    Utopia: connect your pdf to the dynamic
world of online information

  1. Association of Trp64Arg mutation of the beta3-adrenergic-receptor with NIDDM and body weight gain. (PubMed id 8721782)1, 2, 4, 9 Fujisawa T.... Ogihara T. (1996)
  2. The beta 3-adrenergic receptor gene and obesity in a population sample of African Americans. (PubMed id 11244458)1, 4, 9 Lowe Jr W.L....Cooper R.S. (2001)
  3. The promoter and intron/exon structure of the human and mouse beta 3- adrenergic-receptor genes. (PubMed id 8389293)1, 2, 9 van Spronsen A.... Emorine L.J. (1993)
  4. Beta3-adrenergic receptor gene, body mass index, bone mineral density and fracture risk in elderly men and women: the Dubbo Osteoporosis Epidemiology Study (DOES). (PubMed id 16820065)1, 4, 9 Wang C.Y....Nguyen T.V. (2006)
  5. Frequency of and interaction between polymorphisms in the beta3-adrenergic receptor and in uncoupling proteins 1 and 2 and obesity in Germans. (PubMed id 11093283)1, 4, 9 Evans D....Beisiegel U. (2000)
  6. Arg64 variant of the beta3-adrenergic receptor is associated with gallstone formation. (PubMed id 17640319)1, 4, 9 Klass D.M....Fuchs M. (2007)
  7. Association of cholecystokinin 1 receptor and beta3-adrenergic receptor polymorphisms with midlife weight gain. (PubMed id 15340101)1, 4, 9 Koda M....Funakoshi A. (2004)
  8. [Common variants in beta 3-adrenergic-receptor and uncoupling protein-2 genes are associated with type 2 diabetes and obesity] (PubMed id 15061987)1, 4, 9 Xiu L.L....Huang Z.M. (2004)
  9. Aldehyde dehydrogenase 2 and beta3-adrenergic receptor gene polymorphisms: their association with elevated liver enzymes and metabolic syndrome. (PubMed id 14506613)1, 4, 9 Murata C....Okazaki I. (2003)
  10. Beta(3)-adrenergic receptor gene variant is associated with upper body obesity only in obese Japanese-American men but not in women. (PubMed id 11532330)1, 4, 9 Kawamura T....Okubo M. (2001)

(in PubMed, OMIM, and NCBI Bookshelf)
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 ANDOR
Aliases
Disorders
Free Text  

  Query String
PubMed
OMIM
NCBI Bookshelf
  (Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
About This Section
Entrez Gene: 155 HGNC: 288 AceView: ADRB3 Ensembl:ENSG00000188778 euGenes: HUgn155
ECgene: ADRB3 Kegg: 155 H-InvDB: ADRB3

(According to HUGE)
About This Section
  --

(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
NameDescription
PharmGKB entry for ADRB3 Pharmacogenomics, SNPs, Pathways
SeattleSNPshttp://pga.gs.washington.edu/data/adrb3/

(Patent information from GeneIP,
Licensable technologies from WIS Yeda, Salk, Tufts,
IP news from LifeMap Sciences, Inc.)
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Patent Information for ADRB3 gene:
Search GeneIP for patents involving ADRB3

GeneCards and IP:
Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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GeneCards Homepage - Last full update: 23 Oct 2013 - Incrementals: 3 Nov 2013 , 7 Nov 2013 , 23 Jan 2014

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