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ADRB3 Gene

protein-coding   GIFtS: 65
GCID: GC08M037822

Adrenoceptor Beta 3

(Previous names: adrenergic, beta-3-, receptor)
  See ADRB3-related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Adrenoceptor Beta 31 2     BETA3AR2
Adrenergic, Beta-3-, Receptor1 2     Beta-3 Adrenergic Receptor2
Beta-3 Adrenoceptor2 3     ADRB3R3
Beta-3 Adrenoreceptor2 3     B3AR3

External Ids:    HGNC: 2881   Entrez Gene: 1552   Ensembl: ENSG000001887787   OMIM: 1096915   UniProtKB: P139453   

Export aliases for ADRB3 gene to outside databases

Previous GC identifers: GC08P037473 GC08M038084 GC08M9E0062 GC08M037939 GC08M036354


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for ADRB3 Gene:
The protein encoded by this gene belongs to the family of beta adrenergic receptors, which mediate
catecholamine-induced activation of adenylate cyclase through the action of G proteins. This receptor is located
mainly in the adipose tissue and is involved in the regulation of lipolysis and thermogenesis. (provided by
RefSeq, Feb 2009)

GeneCards Summary for ADRB3 Gene:
ADRB3 (adrenoceptor beta 3) is a protein-coding gene. Diseases associated with ADRB3 include obesity, and glucose intolerance. GO annotations related to this gene include protein homodimerization activity and norepinephrine binding. An important paralog of this gene is TAAR6.

UniProtKB/Swiss-Prot: ADRB3_HUMAN, P13945
Function: Beta-adrenergic receptors mediate the catecholamine-induced activation of adenylate cyclase through the
action of G proteins. Beta-3 is involved in the regulation of lipolysis and thermogenesis

summary for ADRB3 Gene:
The adrenergic beta3 receptor (beta3-adrenoceptor) is a member of the adrenergic receptor group of
G-protein-coupled receptors that also includes alpha1A, alpha1B, alpha1D, alpha2A, alpha2B, alpha2C, beta1
and beta2. They are located primarily in the small intestine, adipose tissue and vascular endothelium where
they are involved in lipolysis, glucose uptake, cardio-inhibition and relaxation of colon, esophagus and
bladder. The human beta3 receptor gene has been localized to chromosome 8 (8p12-8p11.1).

Gene Wiki entry for ADRB3 (Beta-3 adrenergic receptor) Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000008.10  NC_018919.2  NT_167187.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the ADRB3 gene promoter:
         GR   STAT1   STAT4   GR-beta   STAT1beta   STAT5A   STAT1alpha   STAT2   STAT3   GR-alpha   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidADRB3 promoter sequence
   Search Chromatin IP Primers for ADRB3

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat ADRB3


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 8p12   Ensembl cytogenetic band:  8p11.23   HGNC cytogenetic band: 8p12

ADRB3 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
ADRB3 gene location

GeneLoc information about chromosome 8         GeneLoc Exon Structure

GeneLoc location for GC08M037822:  view genomic region     (about GC identifiers)

Start:
37,820,513 bp from pter      End:
37,824,483 bp from pter
Size:
3,971 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., eBioscience, and/or antibodies-online,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., eBioscience, and/or antibodies-online, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, Cloud-Clone Corp, antibodies-online, and/or others.)
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UniProtKB/Swiss-Prot: ADRB3_HUMAN, P13945 (See protein sequence)
Recommended Name: Beta-3 adrenergic receptor  
Size: 408 amino acids; 43519 Da
1 PDB 3D structure from and Proteopedia for ADRB3:
2CDW (3D)    
Secondary accessions: Q4JFT4

Explore the universe of human proteins at neXtProt for ADRB3: NX_P13945

Explore proteomics data for ADRB3 at MOPED

Post-translational modifications: 

  • Glycosylation2 at Asn8, Asn26

  • See ADRB3 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_000016.1  
    ENSEMBL proteins: 
     ENSP00000343782  
    Reactome Protein details: P13945

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    Browse Proteins at Cloud-Clone Corp.

     
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    antibodies-online proteins for ADRB3 (3 products) 

     
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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    ADRB: GPCR / Class A : Adrenoceptors : beta

    IUPHAR Guide to PHARMACOLOGY protein family classification: beta3-adrenoceptor
    Adrenoceptors

    4 InterPro protein domains:
     IPR017452 GPCR_Rhodpsn_7TM
     IPR000681 ADRB3_rcpt
     IPR002233 ADR_fam
     IPR000276 GPCR_Rhodpsn

    Graphical View of Domain Structure for InterPro Entry P13945

    ProtoNet protein and cluster: P13945

    2 Blocks protein domains:
    IPB000681 Beta-3 adrenergic receptor signature
    IPB002233 Adrenergic receptor signature


    UniProtKB/Swiss-Prot: ADRB3_HUMAN, P13945
    Similarity: Belongs to the G-protein coupled receptor 1 family. Adrenergic receptor subfamily. ADRB3 sub-subfamily


    Find genes that share domains with ADRB3           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: ADRB3_HUMAN, P13945
    Function: Beta-adrenergic receptors mediate the catecholamine-induced activation of adenylate cyclase through the
    action of G proteins. Beta-3 is involved in the regulation of lipolysis and thermogenesis

         Genatlas biochemistry entry for ADRB3:
    adrenergic,beta-3-,receptor,G protein coupled receptor superfamily,mostly expressed in brown and white adipose
    tissue,activating adenylate cyclase,susceptibility gene for hypertension in the Sardinian population
    (polymorphism W64R) and for obesity in Mexican-American population

         Gene Ontology (GO): Selected molecular function terms (see all 9):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0004930G-protein coupled receptor activity ----
    GO:0004939beta-adrenergic receptor activity IDA15123695
    GO:0004940beta1-adrenergic receptor activity IEA--
    GO:0005515protein binding IPI15123695
    GO:0015052beta3-adrenergic receptor activity IMP9892244
         
    Find genes that share ontologies with ADRB3           About GenesLikeMe


    Phenotypes:
         5 MGI mutant phenotypes (inferred from 2 alleles(MGI details for Adrb3):
     adipose tissue  behavior/neurological  endocrine/exocrine gland  growth/size/body  homeostasis/metabolism 

    Find genes that share phenotypes with ADRB3           About GenesLikeMe

    Animal Models:
         MGI mouse knock-outs for ADRB3: Adrb3tm1Lowl Adrb3tm1Jpg

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    Inhib. RNA
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    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    ADRB3_HUMAN, P13945: Cell membrane; Multi-pass membrane protein
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    plasma membrane5
    mitochondrion2
    nucleus2
    extracellular1

    Gene Ontology (GO): Selected cellular component terms (see all 6):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus IEA--
    GO:0005886plasma membrane TAS--
    GO:0005887integral component of plasma membrane TAS1718744
    GO:0016020membrane ----
    GO:0016021integral component of membrane ----

    Find genes that share ontologies with ADRB3           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for ADRB3 About   (see all 12)  
    See pathways by source

    SuperPathContained pathways About
    1Peptide ligand-binding receptors
    Class A/1 (Rhodopsin-like receptors)0.71
    GPCRs, Class A Rhodopsin-like0.43
    GPCR ligand binding0.71
    Neuroactive ligand-receptor interaction0.36
    2Monoamine GPCRs
    Monoamine GPCRs0.79
    Adrenoceptors0.00
    Amine ligand-binding receptors0.79
    3Ca-dependent events
    Beta 2 adrenergic dependent CFTR expression0.50
    Development Beta adrenergic receptors signaling via cAMP0.32
    4Signaling by GPCR
    Signaling by GPCR0.90
    Signal Transduction0.58
    GPCR downstream signaling0.90
    5Activation of cAMP-Dependent PKA
    Activation of cAMP-Dependent PKA0.77
    Activation of PKA through GPCR0.71
    cAMP Pathway0.77


    Find genes that share SuperPaths with ADRB3           About GenesLikeMe

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    3 Downloadable PowerPoint Slides of GeneGlobe Pathway Central Maps for ADRB3
        Activation of PKA through GPCR
    cAMP Pathway
    Activation of cAMP-Dependent PKA

    5 GeneGo (Thomson Reuters) Pathways for ADRB3
        Development Ligand-independent activation of ESR1 and ESR2
    Development Beta-adrenergic receptors signaling via cAMP
    Beta-2 adrenergic-dependent CFTR expression
    Transcription CREB pathway
    Development Beta-adrenergic receptors regulation of ERK

    3 BioSystems Pathways for ADRB3
        Calcium Regulation in the Cardiac Cell
    GPCRs, Class A Rhodopsin-like
    Monoamine GPCRs

    2 Reactome Pathways for ADRB3
        G alpha (s) signalling events
    Adrenoceptors


    4 Kegg Pathways  (Kegg details for ADRB3):
        Calcium signaling pathway
    Neuroactive ligand-receptor interaction
    Endocytosis
    Salivary secretion

        Pathway & Disease-focused RT2 Profiler PCR Arrays including ADRB3: 
              Neurotransmitter Receptors in human mouse rat
              Insulin Signaling Pathway in human mouse rat
              G Protein Coupled Receptors 384HT in human mouse rat
              Diabetes in human mouse rat

    Interactions:

        GeneGlobe Interaction Network for ADRB3

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for ADRB3 (P139453 ENSP000003437824) via UniProtKB, MINT, STRING, and/or I2D (see all 77)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    ADRB2P075503, ENSP000003053724I2D: score=1 STRING: ENSP00000305372
    GNASQ5JWF23, ENSP000003601414I2D: score=1 STRING: ENSP00000360141
    SRCP129313, ENSP000003509414I2D: score=2 STRING: ENSP00000350941
    ADCY2ENSP000003429524STRING: ENSP00000342952
    ADRB1ENSP000003583014STRING: ENSP00000358301
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 22):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0002024diet induced thermogenesis IEA--
    GO:0002025vasodilation by norepinephrine-epinephrine involved in regulation of systemic arterial blood pressure IEA--
    GO:0002032NOT desensitization of G-protein coupled receptor protein signaling pathway by arrestin IDA15123695
    GO:0005975carbohydrate metabolic process TAS2570461
    GO:0006091generation of precursor metabolites and energy TAS2570461

    Find genes that share ontologies with ADRB3           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Compounds for ADRB3 available from Tocris Bioscience    About this table
    CompoundAction CAS #
    BRL 37344, sodium salt beta3 agonist[127299-93-8]
    L-748,337 Selective beta3 antagonist[244192-94-7]
    SR 59230A hydrochloridePotent and selective beta3 antagonist[1135278-41-9]
    CL 316243 disodium saltHighly selective beta3 agonist[151126-84-0]
    SR 58611A hydrochloridebeta3 agonist; displays anxiolytic and antidepressant effects[121524-09-2]

    2 HMDB Compounds for ADRB3    About this table
    CompoundSynonyms CAS #PubMed Ids
    Norepinephrine(-)-(R)-Norepinephrine (see all 32)51-41-2--
    PropranololDociton (see all 8)525-66-6--

    Selected DrugBank Compounds for ADRB3 (see all 11)    About this table
    CompoundSynonyms CAS #TypeActionsPubMed Ids
    NorepinephrineArterenol (see all 4)51-41-2targetagonist8105356 8097243 9464897 17139284 17016423 8106131
    DroxidopaDroxydopa (see all 4)23651-95-8targetagonist18064417 9464897 19110970 19434307
    BupranololBupranol (see all 2)23284-25-5targetantagonist14660028 12606631
    IsoproterenolEpinephrine Isopropyl Homolog (see all 14)7683-59-2targetagonist10722 10824635
    PropranololDl-Propranolol Hydrochloride (see all 7)525-66-6targetantagonist20231523 11752352
    Arbutamine-- 128470-16-6targetagonist8723169
    Bopindolol-- 69010-88-4target--11752352
    Clenbuterol-- 37148-27-9targetagonist20590599
    EphedraChinese jointfir (see all 3)--targetagonist10449190
    FenoterolFenoterolum [inn-latin] (see all 2)13392-18-2targetagonist14730417

    Selected IUPHAR Ligands for ADRB3 (beta3-adrenoceptor) (see all 22)    About this table
    LigandTypeActionAffinityPubmed IDs
    L 755507
    AgonistFull agonist10.120590599
    [125I]ICYP
    AgonistPartial agonist9.2 - 9.89131260 9117106 8982677 10079020 14744619
    carvedilol
    AntagonistAntagonist9.410411574
    L742791
    AgonistAgonist8.89873496
    carazolol
    AgonistFull agonist8.78719421
    tertatolol
    AntagonistAntagonist8.614744619
    L-748337
    AntagonistAntagonist8.410411574
    SR59230A
    AntagonistAntagonist6.9 - 8.410411574 8730727 14730417
    CGP 12177
    AgonistPartial agonist6.1 - 7.38719421 7903415 9117106 10079020
    bupranolol
    AntagonistAntagonist6.8 - 7.310411574 8719421 7903415 10079020

    Selected Novoseek inferred chemical compound relationships for ADRB3 gene (see all 41)    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    brl37344 84.5 7 10188996 (1), 17067575 (1), 12670949 (1), 10411574 (1) (see all 5)
    cgp 12177 78.8 4 10800773 (1), 18704193 (1)
    bupranolol 67.7 7 12909312 (1), 17626794 (1), 7601122 (1), 9915482 (1) (see all 5)
    isoproterenol 61.9 14 10824635 (2), 9607772 (2), 18704193 (2), 10188996 (1) (see all 9)
    benzenesulfonamide 61.9 3 9871716 (1), 11055339 (1), 10999482 (1)
    glucose 58.1 61 9828912 (4), 9826220 (3), 9845761 (3), 9313101 (2) (see all 35)
    nadolol 47.9 5 10824635 (1), 12909312 (1), 18704193 (1)
    lipid 45.1 49 18482921 (4), 12370850 (3), 9845761 (3), 11003049 (3) (see all 31)
    procaterol 40.6 1 10188996 (1)
    arginine 40.1 17 8690160 (1), 9133593 (1), 9426386 (1), 12561621 (1) (see all 14)

    1 PharmGKB related drug/compound annotation for ADRB3 gene    About this table
    Drug/compound PharmGKB Annotation
    olanzapineCA  



    Find genes that share compounds with ADRB3           About GenesLikeMe



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for ADRB3 gene: 
    NM_000025.2  

    Unigene Cluster for ADRB3:

    Adrenoceptor beta 3
    Hs.2549  [show with all ESTs]
    Unigene Representative Sequence: NM_000025
    2 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000345060(uc003xkr.2) ENST00000520341
    miRNA
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    Additional mRNA sequence: 

    AK293033.1 AK313857.1 AY487247.1 BC075017.2 S53291.1 X70811.1 

    2 DOTS entries:

    DT.455704  DT.100741406 

    Selected AceView cDNA sequences (see all 28):

    BM728296 AL553958 AY487247 NM_000025 S53291 BC075017 X70811 AL550996 
    AL553957 BV194192 BM543956 BV198899 AL550664 BV183211 AI276134 BV198897 
    BV198898 BX281822 BV198900 BV194193 BP381136 BM546330 AL574813 BQ024407 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    ADRB3 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: GTGTGTGTGT
    ADRB3 Expression
    About this image


    ADRB3 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 3) fully expand
     
     Adipose (Muscoskeletal System)    fully expand to see all 6 entries
             Body Subcutaneous White Adipose
             Brown adipocyte-like cells
             epididymal fat pads   
     
     Dermis (Integumentary System)    fully expand to see all 2 entries
             Zigzag Dermal Papilla Cells Dermal Papilla
     
     Gonad (Reproductive System)
             Primordial Germ Cells Primitive Gonad
    ADRB3 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    ADRB3 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.2549

    UniProtKB/Swiss-Prot: ADRB3_HUMAN, P13945
    Tissue specificity: Expressed mainly in adipose tissues

        Pathway & Disease-focused RT2 Profiler PCR Arrays including ADRB3: 
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              Diabetes in human mouse rat

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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of animals.

    Orthologs for ADRB3 gene from Selected species (see all 12)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Adrb31 , 5 adrenergic receptor, beta 31, 5 81.33(n)1
    81.84(a)1
      8 (15.94 cM)5
    115561  NM_013462.31  NP_038490.21 
     272257765 
    chicken
    (Gallus gallus)
    Aves LOC4309911 beta-4C adrenergic receptor-like 71.31(n)
    67.25(a)
      430991  XM_004947587.1  XP_004947644.1 
    lizard
    (Anolis carolinensis)
    Reptilia ADRB36
    adrenoceptor beta 3
    46(a)
    1 ↔ 1
    GL343406.1(536199-540859)
    tropical clawed frog
    (Xenopus tropicalis)
    Amphibia LOC1004870861 beta-4C adrenergic receptor-like 61.81(n)
    62.15(a)
      100487086  XM_002932693.2  XP_002932739.1 
    zebrafish
    (Danio rerio)
    Actinopterygii adrb3a1 adrenergic receptor, beta 3a 56.57(n)
    57.24(a)
      558248  NM_001128335.1  NP_001121807.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta CG74313 G-protein coupled receptor protein
    signaling pathway more
    40(a)
    (best of 4)
        --


    ENSEMBL Gene Tree for ADRB3 (if available)
    TreeFam Gene Tree for ADRB3 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for ADRB3 gene
    TAAR62  HTR62  TAAR22  ADRB12  TAAR92  TAAR82  HRH22  DRD12  
    TAAR12  ADRB22  HTR42  DRD52  TAAR52  
    15 SIMAP similar genes for ADRB3 using alignment to 4 protein entries:     ADRB3_HUMAN (see all proteins):
    DRD2    ADRB2    hA2aR    ADRB1    ADRA1B    ADRA1A
    HTR5A    ADRA1D    DRD5P1    alpha 1c-adrenoceptor subtype    DRD1    HTR1B
    HRH2    HTR7    HTR6

    Find genes that share paralogs with ADRB3           About GenesLikeMe



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Polymorphic Variants from UniProtKB/Swiss-Prot
    ADRB3_HUMAN, P13945: The variant Arg-64 seems to be associated with weight gain (obesity) and is also associated with
    susceptibility to non-insulin-dependent diabetes mellitus (NIDDM)


    Selected SNPs for ADRB3 (see all 330)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 8 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs49941,2,,4
    C,F,Hother138051172(-) TCGCCT/CGGACT 2 /R /W mis136Minor allele frequency- C:0.11MN EA NS NA WA CSA EU 9488
    rs1875873101,2
    --36360542(+) TCACCA/GTGTCC 1 -- us2k10--------
    rs39904011,2
    C--37820698(+) acaca-/CACCATG 1 -- ut310--------
    rs101090281,2
    C,F--37825153(+) agccaT/Ccgcgc 1 -- us2k12Minor allele frequency- C:0.01NS 94
    rs132706561,2
    C,F--37825156(+) caccgC/G/Tgcccg 1 -- us2k13NS CSA 95
    rs96941971,2
    C,F,H--38047467(+) CAGACA/GCCAGA 1 -- ds500126Minor allele frequency- G:0.21NS EA NA WA CSA 2434
    rs1512775591,2
    --38047515(+) CTTTGA/GTATGA 1 -- ds50010--------
    rs1854043721,2
    --38047722(+) TTACCA/GGGCAT 1 -- ds50010--------
    rs1402642501,2
    C--38047761(+) GGCTCA/GTAGAG 1 -- ds50010--------
    rs346190571,2
    C,F--38047804(-) TTCTAA/TGGAAA 1 -- ds50017Minor allele frequency- T:0.09NS NA WA EA 456

    HapMap Linkage Disequilibrium report for ADRB3 (37820513 - 37824483 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 1 variation for ADRB3:    About this table    
    Variant IDTypeSubtypePubMed ID
    nsv890719CNV Loss21882294

    Human Gene Mutation Database (HGMD): ADRB3
    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing ADRB3
    DNA2.0 Custom Variant and Variant Library Synthesis for ADRB3

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 109691   
    OMIM disorders: 601665  
    7 diseases for ADRB3:    
    About MalaCards
    obesity    glucose intolerance    morbid obesity    hyperuricemia
    insulin resistance    essential hypertension    type 2 diabetes mellitus

    2 diseases from the University of Copenhagen DISEASES database for ADRB3:
    Diabetes mellitus     Hypertension

    Find genes that share disorders with ADRB3           About GenesLikeMe

    Selected Novoseek inferred disease relationships for ADRB3 gene (see all 41)    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    obesity 79 187 12709137 (4), 10480620 (4), 15061987 (3), 11093283 (3) (see all 99)
    insulin resistance 74.1 90 9405912 (3), 10707554 (3), 8954053 (3), 11532330 (3) (see all 56)
    niddm 69.8 74 10414939 (2), 18249219 (2), 10826514 (2), 7609750 (2) (see all 43)
    overactive bladder 51.6 8 12007519 (2), 17600372 (1), 17011390 (1), 17626794 (1)
    insulin sensitivity 49.2 12 8690160 (2), 9313101 (2), 10707551 (1), 15472194 (1) (see all 8)
    impaired glucose tolerance 46.9 4 9313101 (1), 9828912 (1), 18249219 (1), 14506613 (1)
    obesity morbid 44.8 7 8968849 (2), 7609752 (2), 8968850 (1), 9416435 (1) (see all 5)
    genetic susceptibility 44.8 7 17998022 (1), 9480495 (1), 10421979 (1), 15743038 (1) (see all 6)
    hyperlipidemia familial combined 42.9 1 12370850 (1)
    metabolic disorder 42.7 6 11798745 (1), 16209345 (1), 15523499 (1), 16276096 (1) (see all 5)

    Genatlas disease: ADRB3
    excess capacity to gain weight in patients with insulin resistance,early onset non insulin dependent diabetes
    and/or morbid obesity,with fatty liver

    Genetic Association Database (GAD): ADRB3
    Human Genome Epidemiology (HuGE) Navigator: ADRB3 (220 documents)

    Export disorders for ADRB3 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for ADRB3 gene, integrated from 10 sources (see all 550):
    (articles sorted by number of sources associating them with ADRB3)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Association of Trp64Arg mutation of the beta3-adrenergic-receptor with NIDDM and body weight gain. (PubMed id 8721782)1, 2, 4, 9 Fujisawa T.... Ogihara T. (Diabetologia 1996)
    2. The beta 3-adrenergic receptor gene and obesity in a population sample of African Americans. (PubMed id 11244458)1, 4, 9 Lowe Jr W.L....Cooper R.S. (Int. J. Obes. Relat. Metab. Disord. 2001)
    3. The promoter and intron/exon structure of the human and mouse beta 3- adrenergic-receptor genes. (PubMed id 8389293)1, 2, 9 van Spronsen A.... Emorine L.J. (Eur. J. Biochem. 1993)
    4. Beta3-adrenergic receptor gene, body mass index, bone mineral density and fracture risk in elderly men and women: the Dubbo Osteoporosis Epidemiology Study (DOES). (PubMed id 16820065)1, 4, 9 Wang C.Y....Nguyen T.V. (BMC Med. Genet. 2006)
    5. Frequency of and interaction between polymorphisms in the beta3-adrenergic receptor and in uncoupling proteins 1 and 2 and obesity in Germans. (PubMed id 11093283)1, 4, 9 Evans D....Beisiegel U. (Int. J. Obes. Relat. Metab. Disord. 2000)
    6. Arg64 variant of the beta3-adrenergic receptor is associated with gallstone formation. (PubMed id 17640319)1, 4, 9 Klass D.M....Fuchs M. (Am. J. Gastroenterol. 2007)
    7. Association of cholecystokinin 1 receptor and beta3-adrenergic receptor polymorphisms with midlife weight gain. (PubMed id 15340101)1, 4, 9 Koda M....Funakoshi A. (Obes. Res. 2004)
    8. [Common variants in beta 3-adrenergic-receptor and uncoupling protein-2 genes are associated with type 2 diabetes and obesity]. (PubMed id 15061987)1, 4, 9 Xiu L.L....Huang Z.M. (Zhonghua Yi Xue Za Zhi 2004)
    9. Aldehyde dehydrogenase 2 and beta3-adrenergic receptor gene polymorphisms: their association with elevated liver enzymes and metabolic syndrome. (PubMed id 14506613)1, 4, 9 Murata C....Okazaki I. (Metab. Clin. Exp. 2003)
    10. Beta(3)-adrenergic receptor gene variant is associated with upper body obesity only in obese Japanese-American men but not in women. (PubMed id 11532330)1, 4, 9 Kawamura T....Okubo M. (Diabetes Res. Clin. Pract. 2001)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 155 HGNC: 288 AceView: ADRB3 Ensembl:ENSG00000188778 euGenes: HUgn155
    ECgene: ADRB3 Kegg: 155 H-InvDB: ADRB3

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
    About This Section

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    NameDescription
    PharmGKB entry for ADRB3 Pharmacogenomics, SNPs, Pathways
    SeattleSNPshttp://pga.gs.washington.edu/data/adrb3/

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for ADRB3 gene:
    Search GeneIP for patents involving ADRB3

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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