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Category Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21

GIFtS
-

ADRB2 Gene

protein-coding GIFtS: 70
GCID: GC05P148186

adrenoceptor beta 2, surface

(Previous names: adrenergic, beta-2-, receptor, surface )
(Previous symbol: ADRB2R)

Explore 157 diseases affiliated with
ADRB2 via

MalaCards

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Human Malady Compendium

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc, ⁷Ensembl, ⁸DME, ⁹miRBase, and/or ¹⁰fRNAdb)
About This Section

Aliases
Adrenoceptor Beta 2, Surface¹ ²		Beta-2 Adrenoceptor² ³
ADRB2R¹ ² ³		Beta-2 Adrenoreceptor² ³
B2AR¹ ² ³		BETA2AR²
ADRBR¹ ²		Beta-2 Adrenergic Receptor²
BAR¹ ²		Catecholamine Receptor²
Adrenergic, Beta-2-, Receptor, Surface¹ ²

External Ids:	HGNC: 286¹	Entrez Gene: 154²	Ensembl: ENSG00000169252⁷	OMIM: 109690⁵	UniProtKB: P07550³

Export aliases for ADRB2 gene to outside databases

Previous GC identifers: GC05P148250 GC05M148800 GC05P148187 GC05P148235 GC05P148236 GC05P143352

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for ADRB2:

This gene encodes beta-2-adrenergic receptor which is a member of the G protein-coupled receptor superfamily. This

receptor is directly associated with one of its ultimate effectors, the class C L-type calcium channel Ca(V)1.2. This

receptor-channel complex also contains a G protein, an adenylyl cyclase, cAMP-dependent kinase, and the

counterbalancing phosphatase, PP2A. The assembly of the signaling complex provides a mechanism that ensures specific

and rapid signaling by this G protein-coupled receptor. This gene is intronless. Different polymorphic forms, point

mutations, and/or downregulation of this gene are associated with nocturnal asthma, obesity and type 2 diabetes.

(provided by RefSeq, Jul 2008)

UniProtKB/Swiss-Prot: ADRB2_HUMAN, P07550

Function: Beta-adrenergic receptors mediate the catecholamine-induced activation of adenylate cyclase through the

action of G proteins. The beta-2-adrenergic receptor binds epinephrine with an approximately 30-fold greater affinity

than it does norepinephrine

summary for ADRB2:

The adrenergic beta2 receptor (beta2-adrenoceptor) is a member of the adrenergic receptor group of

G-protein-coupled receptors that also includes alpha1A, alpha1B, alpha1D, alpha2A, alpha2B, alpha2C, beta1

and beta3. They are located primarily in the CNS, heart, kidney and muscle where they are involved in smooth

muscle relaxation (e.g. bronchodilation). The human adrenergic beta2 receptor gene has been localized to

chromosome 5 (5q31-q32).

Gene Wiki entry for ADRB2 (Beta-2 adrenergic receptor)

PharmGKB "VIP" summary for ADRB2

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section

RefSeq DNA sequence:

NC_000005.9 NC_018916.1 NT_029289.11

Regulatory elements:

SABiosciences Regulatory transcription factor binding sites in the ADRB2 gene promoter:
CREB p53 deltaCREB STAT3 MyoD
Other transcription factors

SwitchGear Promoter luciferase reporter plasmids (see all 2): ADRB2 promoter sequence

Search SABiosciences Chromatin IP Primers for ADRB2

Epigenetics:

QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat ADRB2

Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 5q31-q32 Ensembl cytogenetic band: 5q32 HGNC cytogenetic band: 5q31-q32

ADRB2 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
ADRB2 gene location

GeneLoc information about chromosome 5 GeneLoc Exon Structure

GeneLoc location for GC05P148186: view genomic region (about GC identifiers)

Start:	148,206,156 bp from pter	End:	148,208,197 bp from pter
Size:	2,042 bases	Orientation:	plus strand

(According to ¹UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to ²PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section

UniProtKB/Swiss-Prot: ADRB2_HUMAN, P07550 (See protein sequence)

Recommended Name: Beta-2 adrenergic receptor

Size: 413 amino acids; 46459 Da

Subunit: Binds SLC9A3R1 and GPRASP1. Interacts with ARRB1 and ARRB2. Interacts with SRC, USP20 and USP33. Interacts

with VHL; the interaction, which is increased on hydroxylation of ADRB2, ubiquitinates ADRB2 leading to its

degradation. Interacts with EGLN3; the interaction hydroxylates ADRB2 facilitating VHL-E3 ligase-mediated

ubiquitination

Subcellular location: Cell membrane; Multi-pass membrane protein. Note=Colocalizes with VHL at the cell membrane

Sequence caution: Sequence=BAD96745.1; Type=Erroneous initiation; Note=Translation N-terminally shortened;

6/13 PDB 3D structures from and Proteopedia for ADRB2 (see all 13):

1GQ4 (3D)

2R4R (3D)

2R4S (3D)

2RH1 (3D)

3D4S (3D)

3KJ6 (3D)

Secondary accessions: B0LPE4 B2R7X2 O14823 O14824 O14825 O14826 Q4JG18 Q53GA6 Q6GMT4 Q6P4D8 Q8NEQ9

Q96EC3 Q9UCZ0 Q9UCZ1 Q9UCZ2 Q9UCZ3 Q9UH95 Q9UHA1 Q9UMZ5

Explore the universe of human proteins at neXtProt for ADRB2: NX_P07550

Post-translational modifications:

Palmitoylated; may reduce accessibility of Ser-345 and Ser-346 by anchoring Cys-341 to the plasma membrane. Agonist

stimulation promotes depalmitoylation and further allows Ser-345 and Ser-346 phosphorylation¹

Phosphorylated by PKA and BARK upon agonist stimulation, which mediates homologous desensitization of the receptor.

PKA-mediated phosphorylation seems to facilitate phosphorylation by BARK¹

Phosphorylation of Tyr-141 is induced by insulin and leads to supersensitization of the receptor¹

Polyubiquitinated. Agonist-induced ubiquitination leads to sort internalized receptors to the lysosomes for

degradation. Deubiquitination by USP20 and USP33, leads to ADRB2 recycling and resensitization after prolonged agonist

stimulation. USP20 and USP33 are constitutively associated and are dissociated immediately after agonist stimulation.

Ubiquitination by the VHL-E3 ligase complex is oxygen-dependent¹

Hydroxylation by EGLN3 occurs only under normoxia and increases the interaction with VHL and the subsequent

ubiquitination and degradation of ADRB2¹

View modification sites using PhosphoSitePlus²

View neXtProt modification sites for NX_P07550

ADRB2 Protein expression data from MOPED and PaxDb: About this image

REFSEQ proteins: NP_000015.1

ENSEMBL proteins:

ENSP00000305372

Reactome Protein details: P07550
Human Recombinant Protein Products for ADRB2:

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	Browse ProSpec Recombinant Proteins
	Browse Proteins at Uscn

Gene Ontology (GO): 5/17 cellular component terms (GO ID links to tree view) (see all 17): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005624	membrane fraction	--	--
GO:0005634	nucleus	IEA	--
GO:0005737	cytoplasm	--	--
GO:0005764	lysosome	TAS	9507004
GO:0005768	endosome	TAS	10734107

ADRB2 for ontologies About GeneDecksing

ADRB2 Antibody Products:

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	ThermoFisher Antibodies for ADRB2

Assay Products for ADRB2:

	Browse Kits and Assays available from EMD Millipore
	OriGene Custom Immunoassay Development Browse OriGene Fluorogenic Cell Assay Kits
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	GenScript ADRB2-overexpressing Cell Line for Assay
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	Browse ELISAs and CLIAs at Uscn

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

ADRB2 for domains About GeneDecksing

4 InterPro domains/families:

IPR017452 GPCR_Rhodpsn_7TM

IPR002233 Adrnrgc_rcpt

IPR000276 GPCR_Rhodpsn

IPR000332 Adrgc_rcpt_B2

Graphical View of Domain Structure for InterPro Entry P07550

ProtoNet protein and cluster: P07550

2 Blocks protein families:

IPB000332 Beta-2 adrenergic receptor signature

IPB002233 Adrenergic receptor signature

UniProtKB/Swiss-Prot: ADRB2_HUMAN, P07550

Similarity: Belongs to the G-protein coupled receptor 1 family. Adrenergic receptor subfamily. ADRB2 sub-subfamily

(According to ¹UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or ²DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory,
bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, Sirion Biotech, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, Sirion Biotech, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
About This Section

Molecular Function:

UniProtKB/Swiss-Prot Summary: ADRB2_HUMAN, P07550

Function: Beta-adrenergic receptors mediate the catecholamine-induced activation of adenylate cyclase through the

action of G proteins. The beta-2-adrenergic receptor binds epinephrine with an approximately 30-fold greater affinity

than it does norepinephrine

Genatlas biochemistry entry for ADRB2:

adrenergic,beta-2-,receptor,G protein coupled receptor superfamily,activating adenylate cyclase,major lipolytic

receptor in human fat cell altered in obesity,also associated to susceptibility to hypertension (polymorphism,R16G)

Gene Ontology (GO): 5/10 molecular function terms (GO ID links to tree view) (see all 10): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0004941	beta2-adrenergic receptor activity	IDA	15123695
GO:0005515	protein binding	IPI	15123695
GO:0008144	drug binding	--	--
GO:0008179	adenylate cyclase binding	IEA	--
GO:0015459	potassium channel regulator activity	IDA	12297500

ADRB2 for ontologies About GeneDecksing

Phenotypes:
2 GenomeRNAi human phenotypes for ADRB2:

Decreased G3BP1 protein expres

Large nuclei

12 MGI mutant phenotypes (inferred from 3 alleles) (MGI details for Adrb2):

adipose tissue	behavior/neurological	cardiovascular system	cellular	endocrine/exocrine gland
growth/size	hematopoietic system	homeostasis/metabolism	immune system	muscle
no phenotypic analysis	skeleton

ADRB2 for phenotypes About GeneDecksing

Animal Models:
Mouse knock-out Adrb2^tm1Bkk for ADRB2

inGenious Targeting Laboratory - Customizable classic, inducible, and humanized mouse model solutions for ADRB2

miRNA Products:		OriGene 3'-UTR Clone: ADRB2 Browse MicroRNA Expression Plasmids
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		8/10 QIAGEN miScript miRNA Assays for microRNAs that regulate ADRB2 (see all 10):
		hsa-miR-98 hsa-let-7d hsa-let-7c hsa-let-7i hsa-miR-1284 hsa-let-7g hsa-let-7e hsa-let-7b

		SwitchGear 3'UTR luciferase reporter plasmid: ADRB2 3' UTR sequence

Inhib. RNA Products:		Browse for Gene Knock-down Tools from EMD Millipore
		OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for ADRB2 (see all 7) OriGene shRNA RFP: ADRB2 OriGene siRNA: ADRB2
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		OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for ADRB2 (see all 3) OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for ADRB2 OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
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In Situ Assay
Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ADRB2

(Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to ¹UniProtKB, ²MINT, ³I2D, and/or ⁴STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
About This Section

Unified GeneCards pathways - 5/25 super-pathways (see all 25) About this table

See pathways by source

Super-pathway

contained gene-specific pathways

Class A/1 (Rhodopsin-like receptors)

	Class A/1 (Rhodopsin-like receptors)	1.00			GPCRs, Class A Rhodopsin-like	0.41
	GPCR ligand binding	0.75			Neuroactive ligand-receptor interaction	0.38

Activation of cAMP-Dependent PKA

	Activation of cAMP-Dependent PKA	1.00			Activation of PKA through GPCR	0.71
	cAMP Pathway	0.77

Signaling by GPCR

	Signaling by GPCR	1.00			Signal Transduction	0.56
	GPCR downstream signaling	0.89

PKA activation in glucagon signalling

	Beta-2 adrenergic-dependent CFTR expression	0.74			Development_Beta-adrenergic receptors signaling via cAMP	0.29
	Development Beta-adrenergic receptors signaling via cAMP	0.29

wtCFTR and deltaF508 traffic / Membrane expression (norm and CF)

wtCFTR and deltaF508 traffic / Membrane expression (norm and CF)

1.00

Regulation of CFTR activity (norm and CF)

0.38

Pathway sources
See GeneCards unified pathways
Show all pathways

4 EMD Millipore Pathways for ADRB2

	Development Beta-adrenergic receptors regulation of ERK
	Development Beta-adrenergic receptors signaling via cAMP
	Transcription CREB pathway
	Development Ligand-independent activation of ESR1 and ESR2

5 Downloadable PowerPoint Slides of QIAGEN Pathway Central Maps for ADRB2

	Activation of PKA through GPCR
	cAMP Pathway
	Activation of cAMP-Dependent PKA
	Signaling Involved in Cardiac Hypertrophy
	Beta-Adrenergic Signaling

2 Cell Signaling Technology (CST) Pathways for ADRB2

	Ca, cAMP and Lipid Signaling
	Neuroscience

5/7 GeneGo (Thomson Reuters) Pathways for ADRB2 (see all 7)

	Development Ligand-independent activation of ESR1 and ESR2
	Development Beta-adrenergic receptors signaling via cAMP
	Beta-2 adrenergic-dependent CFTR expression
	Transcription CREB pathway
	Regulation of CFTR activity (norm and CF)

5/6 BioSystems Pathways for ADRB2 (see all 6)

	Calcium Regulation in the Cardiac Cell
	GPCRs, Class A Rhodopsin-like
	GPCRs, Other
	Arf6 trafficking events
	Arf6 signaling events

5/8 Reactome Pathways for ADRB2 (see all 8)

	GPCR downstream signaling
	Signaling by GPCR
	GPCR ligand binding
	Adrenoceptors
	Class A/1 (Rhodopsin-like receptors)

3 PharmGKB Pathways for ADRB2

	Antiarrhythmic Pathway, Pharmacodynamics
	Beta-agonist/Beta-blocker Pathway, Pharmacodynamics
	Sympathetic Nerve Pathway (Neuroeffector Junction)

4 Kegg Pathways (Kegg details for ADRB2):

	Calcium signaling pathway
	Neuroactive ligand-receptor interaction
	Endocytosis
	Salivary secretion

ADRB2 for pathways About GeneDecksing

Interactions:

SABiosciences Gene Network Central^TM Interacting Genes and Proteins Network for ADRB2

STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

5/124 Interacting proteins for ADRB2 (P07550^{2, 3} ENSP00000305372⁴) via UniProtKB, MINT, STRING, and/or I2D (see all 124)

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
SLC9A3R1	O14745²^,³, ENSP00000262613⁴	MINT-1796489 MINT-2842955 MINT-1796525 MINT-2843018 MINT-2842994 MINT-1796656 MINT-2842879 MINT-2842917 I2D: score=6 STRING: ENSP00000262613
MAGI3	Q5TCQ9²^,³, ENSP00000304604⁴	MINT-7716320 MINT-7716382 MINT-7716556 MINT-7716470 MINT-7716630 MINT-7716422 MINT-7716450 MINT-7716335 MINT-7716502 I2D: score=2 STRING: ENSP00000304604
LAMP2	P13473²^,³, ENSP00000408411⁴	MINT-7291650 I2D: score=1 STRING: ENSP00000408411
SRC	P12931²^,³, ENSP00000350941⁴	MINT-4051805 MINT-4051815 MINT-4051585 I2D: score=4 STRING: ENSP00000350941
USP33	Q8TEY7²^,³, ENSP00000350009⁴	MINT-7291631 MINT-7291604 I2D: score=1 STRING: ENSP00000350009

About this table

Gene Ontology (GO): 5/41 biological process terms (GO ID links to tree view) (see all 41): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0001993	regulation of systemic arterial blood pressure by norepinephrine-epinephrine	--	--
GO:0002024	diet induced thermogenesis	IEA	--
GO:0002025	vasodilation by norepinephrine-epinephrine involved in regulation of systemic arterial blood pressure	IEA	--
GO:0002028	regulation of sodium ion transport	IEA	--
GO:0002032	desensitization of G-protein coupled receptor protein signaling pathway by arrestin	IDA	15123695

ADRB2 for ontologies About GeneDecksing

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
About This Section

ADRB2 for compounds About GeneDecksing

Browse Small Molecules at EMD Millipore

Browse drugs & compounds from Enzo Life Sciences

Compounds for ADRB2 available from Tocris Bioscience About this table

Compound	Action	CAS #
ICI 118,551 hydrochloride	Very selective beta2 antagonist	[72795-01-8]
Salmeterol	Potent beta2 agonist; long acting	[89365-50-4]
Salbutamol hemisulfate	beta agonist (beta2 > beta1)	[51022-70-9]
Formoterol hemifumarate	Potent and selective beta2 agonist	[183814-30-4]

5 HMDB Compounds for ADRB2 About this table

Compound	Synonyms	CAS #	PubMed Ids
Epinephrine	(-)-(R)-Epinephrine (see all 72)	51-43-4	--
Norepinephrine	(-)-(R)-Norepinephrine (see all 32)	51-41-2	--
Propranolol	Dociton (see all 8)	525-66-6	--
Pseudoephedrine	(+)-(1S,2S)-Pseudoephedrine (see all 25)	90-82-4	--
Salbutamol	(l)-albuterol (see all 97)	18559-94-9	--

10/47 DrugBank Compounds for ADRB2 (see all 47) About this table

Compound	Synonyms	CAS #	Type	Actions	PubMed Ids
Formoterol	Formoterol fumarate (see all 2)	73573-87-2	target	agonist	17594727 14720051 12090787 9506248 11752352 16432501 1718682 18686730 7675115 14662724 2544117
Terbutaline	Terbutalin (see all 5)	23031-25-6	target	agonist	2062329 1358833 11675405 11752352 20674738 18782903 11256987 12569076 11120594 10226872
Arformoterol	--	67346-49-0	target	agonist	17352511 17594727 20406080 16022567 18501650 14725487 11752352 17472819
Norepinephrine	Arterenol (see all 4)	51-41-2	target	agonist	18064417 9666280 9464897 17139284 17016423 19110970 7969507 11504801
Bambuterol	--	81732-46-9	target	agonist	20012638 8885698 8223836 11752352 3262993 18065099 12065188
Isoproterenol	Epinephrine Isopropyl Homolog (see all 14)	7683-59-2	target	agonist	12963495 15151902 14656380 10722 11752352 15105445 14752060
Labetalol	Labetalol HCL (see all 4)	36894-69-6	target	antagonist	19879818 1361547 2907566 6355664 11752352 7684671 8104240
Levobunolol	Levobunolol HCl (see all 2)	47141-42-4	target	antagonist	6147147 7928182 2891463 11752352 2892662 1351412 11572462
Timolol	Timolol maleate (see all 2)	26839-75-8	target	antagonist	16205624 9730867 11752352 8103526 8719802 9088585 10592235
Bopindolol	--	69010-88-4	target	partial agonist	1687398 1678274 1979630 16574446 11752352 1666931

10/116 Novoseek chemical compound relationships for ADRB2 gene (see all 116) About this table

Compound	-log (P-Val)	Hits	PubMed IDs for Articles with Shared Sentences (# sentences)
isoproterenol	84.9	122	10510435 (4), 15178407 (3), 17885618 (3), 10840035 (3) (see all 67)
zinterol	77.1	8	18467626 (2), 9915773 (2), 9872996 (1), 9884381 (1)
salbutamol	76.8	51	20335826 (3), 9873044 (3), 15557128 (2), 15687340 (2) (see all 31)
icyp	75	2	1352549 (1), 15110997 (1)
terbutaline	74	38	12966369 (4), 16153394 (3), 17718540 (2), 12869379 (2) (see all 16)
catecholamine	73.2	102	7608992 (3), 11591153 (3), 8756182 (2), 8685890 (2) (see all 72)
carazolol	72.6	4	19353579 (1), 7601122 (1), 17962520 (1), 18821775 (1)
salmeterol	72.4	40	9765503 (5), 16980556 (4), 17030231 (4), 8798639 (3) (see all 14)
alprenolol	70.5	3	10822171 (1), 11041870 (1), 9494078 (1)
butoxamine	69.2	12	15145612 (1), 16551744 (1), 16645459 (1), 15458278 (1) (see all 5)

3 PharmGKB related drug/compound annotations for ADRB2 gene About this table

Drug/compound	PharmGKB Annotation
carvedilol	CA
salbutamol	CA
salmeterol	CA

Search CenterWatch for drugs/clinical trials and news about ADRB2

(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from EMD Millipore,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, Sirion Biotech, microRNA from QIAGEN,
Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
About This Section

REFSEQ mRNAs for ADRB2 gene:

NM_000024.5

Unigene Cluster for ADRB2:

Adrenoceptor beta 2, surface

Hs.2551 [show with all ESTs]

Unigene Representative Sequence: M15169

1 Ensembl transcript including schematic representation, and UCSC links where relevant:

ENST00000305988(uc003lpr.2)

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Additional cDNA sequence:

AK223025.1 AK313151.1 AY136741.1 BC012481.2 BC063486.1 BC073856.1 M15169.1 X04827.1

1 DOTS entry:

DT.313911

24/50 AceView cDNA sequences (see all 50):

BC073856 BM544409 BQ447101 CR595085 AV647785 AL553611 BI915042 M15169

CA440083 NM_000024 BX092021 CN837362 AY136741 BQ017003 X04827 BM702832

BG256156 BC063486 BP366282 BP347785 BC012481 AA948091 R82937 BP380312

GeneLoc Exon Structure

(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section

ADRB2 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: GACTCTTCCC

About this image

ADRB2 expression in embryonic tissues and stem cells
Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine About this table

2 LifeMap In Vivo Development Anatomical Compartments/Cells

Tissue

Anatomical Compartment

Cell

Category (developmental path)

Ovary

Antral Follicle

Cumulus Cells

Ovary

Liver

Liver Lobule

Liver

Expression:

Positive

Negative

Selective marker

Experimental details:

Curated

Microarrays

In-situ hybridization

Stem Cell Differentiation: 2 LifeMap Cells

Name

Category

White adipocyte-like cells (Differentiation of w...)

Brown adipocyte-like cells (Differentiation of w...)

See ADRB2 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for ADRB2

SOURCE GeneReport for Unigene cluster: Hs.2551

SABiosciences Expression via Pathway-Focused PCR Arrays including ADRB2 (see all 7):

Neurotransmitter Receptors in human mouse rat

G-Protein-Coupled Receptor Signaling PathwayFinder in human mouse rat

G Protein Coupled Receptors 384HT in human mouse rat

Skeletal Muscle: Myogenesis & Myopathy in human mouse rat

Gap Junctions in human mouse rat

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In Situ
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(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD , ⁵MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or ⁶Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
About This Section

This gene was present in the common ancestor of chordates.

Orthologs for ADRB2 gene from 4/15 species (see all 15) About this table

Organism	Taxonomic classification	Gene	Description	Human Similarity	Orthology Type	Details
chicken (Gallus gallus)	Aves	ADRB2¹	adrenergic, beta-2-, receptor, surface	78.47(n) 80.27(a)		427623 XM_425195.3 XP_425195.2
lizard (Anolis carolinensis)	Reptilia	ADRB2⁶	--	67(a)	1 ↔ 1	2(123333789-123335460)
African clawed frog (Xenopus laevis)	Amphibia	MGC68724²	hypothetical protein MGC68724	78.83(n)		BC060426.1
zebrafish (Danio rerio)	Actinopterygii	adrb2b¹	adrenergic receptor, beta 2b	66.67(n) 65.11(a)		100037315 NM_001089471.1 NP_001082940.1

ENSEMBL Gene Tree for ADRB2 (if available)
TreeFam Gene Tree for ADRB2 (if available)

(Paralogs according to ¹HomoloGene,
²Ensembl, and ³SIMAP, Pseudogenes according to ⁴Pseudogene.org Build 68)
About This Section

Paralogs for ADRB2 gene

TAAR6² HTR2A² HTR6² TAAR2² ADRB1² TAAR8² HRH2² HTR2B²

DRD1² HTR2C² TAAR1² HTR4² DRD5² ADRB3² TAAR5²

18/30 SIMAP similar genes for ADRB2 using alignment to 2 protein entries: ADRB2_HUMAN (see all proteins) (see all similar genes):

5-HT7 ADRB1 ADRB3 DRD1 CHRM5 hA2aR

DRD5 HRH3 HRH2 HTR4 TAAR1 TAAR9

DRD5P1 HTR1D HTR4B TAAR8 ADRA1A ADRA2C

ADRB2 for paralogs About GeneDecksing

(SNPs/Variants according to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section

UniProtKB/Swiss-Prot: ADRB2_HUMAN, P07550

Polymorphism: The Gly-16 allele is overrepresented in individuals affected by nocturnal asthma as compared to controls,

and appears to be an important genetic factor in the expression of this asthmatic phenotype

SNP ID	Valid	Clinical significance	Chr 5 pos	Sequence	#	AA Chg	Type	More	#	Pop	Total sample
Genomic Data					Transcription Related Data				Allele Frequencies
				--	--	--		--	--
rs1800888^1,2	C,F,H	drug-response	157211008(+)	`CCTTAC/TCTCCT`	2	T I	mis¹ trp³		18	NS EA NA EU	12345
rs35140776^1,2	C	--	143351252(+)	`AAGATC/TTTACT`	1	--	us2k¹		4	NS	1558
rs34360528^1,2	C	--	143351337(+)	`AGATGG/AAGTCT`	1	--	us2k¹		3	NS	1066
rs34927547^1,2	C	--	143351707(+)	`ATTGGG/TTTTAC`	1	--	us2k¹		3	NS NA	96
rs41371044^1,2	C,F	--	143352095(+)	`CAGATG/AGAGAC`	1	--	us2k¹		1	--	980
rs17287460^1,2	C,F	--	143352281(+)	`CATGTC/AGGTGA`	1	--	us2k¹ ese³		2	--	6390
rs17334228^1,2	C,F	--	143352584(+)	`TGGCCC/TGCCCT`	1	--	us2k¹ ese³		10	NS MN WA	7463
rs34432211^1,2	F	--	143352585(+)	`GGCCCGCCCTCCAGGGAG CAGTTGGGCCCC/-CCCTC`	1	--	us2k¹		1	--	592
rs45630460^1,2	F	--	143352613(+)	`CCGCC-/CTCCAGGGAGCA GTTGGGCCCCGCCCGGGCC`	1	--	us2k¹		1	--	964
rs35372244^1,2	C	--	143352713(+)	`GTTCCC/TGTACG`	1	--	us2k¹		2	NS	92

HapMap Linkage Disequilibrium report for ADRB2 (148206156 - 148208197 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV) variations for ADRB2: --
Human Gene Mutation Database (HGMD): ADRB2

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(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
About This Section

ADRB2 for disorders           About GeneDecksing

OMIM gene information: 109690
OMIM disorders: 600807  601665
20/157 diseases for ADRB2 (see all 157):    About MalaCards

beta-2-adrenoreceptor agonist, reduced response to (3) 18 open-angle glaucoma asthma resting heart rate

attention deficit hyperactivity disorder obesity spinal cord injury thyrotoxic periodic paralysis

status asthmaticus primary open angle glaucoma congenital aortic valve stenosis complex regional pain syndrome

acute mountain sickness patent ductus arteriosus acanthosis nigricans adult respiratory distress syndrome

myasthenia gravis aortic valve stenosis long qt syndrome asthma, nocturnal

3 diseases from the University of Copenhagen DISEASES database for ADRB2:

Asthma Hypertension Heart disease

10/93 Novoseek disease relationships for ADRB2 gene (see all 93) About this table

Disease	-log (P-Val)	Hits	PubMed IDs for Articles with Shared Sentences (# sentences)
asthma	68.9	256	18156033 (5), 16357573 (5), 10374285 (5), 15153795 (5) (see all 99)
status asthmaticus	42.2	4	16395068 (3), 12628991 (1)
heart failure	39.4	22	17117186 (2), 11208703 (1), 14573333 (1), 18353108 (1) (see all 21)
obesity	39.2	73	11288039 (5), 19779622 (5), 17907319 (3), 11016907 (3) (see all 31)
essential hypertension	39	28	17963627 (2), 12361188 (2), 10981553 (2), 19102885 (2) (see all 13)
cholera	36.7	4	10822171 (2), 10473590 (1), 17008315 (1)
atopy	29	1	11941312 (1)
pulmonary disease chronic obstructive	25.8	13	16463710 (1), 16861834 (1), 18667995 (1), 19293197 (1) (see all 11)
lung diseases obstructive	25.4	2	19706446 (1), 18024720 (1)
heart failure congestive	20.8	10	17361123 (3), 9788966 (1), 17336757 (1), 11392464 (1) (see all 7)

Genetic Association Database (GAD): ADRB2
Human Genome Epidemiology (HuGE) Navigator: ADRB2 (507 documents)

Export disorders for ADRB2 gene to outside databases

(in PubMed. Associations of this gene to articles via ¹Entrez Gene, ²UniProtKB/Swiss-Prot, ³HGNC, ⁴GAD, ⁵PharmGKB, ⁶HMDB, ⁷DrugBank, ⁸UniProtKB/TrEMBL, ⁹ Novoseek, and/or ¹⁰fRNAdb)
About This Section

PubMed articles for ADRB2 gene, integrated from 9 sources (see all 1621):
(articles sorted by number of sources associating them with ADRB2)

Utopia: connect your pdf to the dynamic
world of online information

Genetic polymorphisms of the beta 2-adrenergic receptor in nocturnal and nonnocturnal asthma. Evidence that Gly16 correlates with the nocturnal phenotype. (PubMed id 7706471)^{1, 2, 4, 9} Turki J.... Liggett S.B. (1995)
Mutations in the gene encoding for the beta 2-adrenergic receptor in normal and asthmatic subjects. (PubMed id 8383511)^{1, 2, 4, 9} Reihsaus E.... Liggett S.B. (1993)
[Beta 2-adrenoceptor polymorphism and effects of inhaled beta 2-stimulant (procaterol) and an anti-cholinergic drug (oxitropium) on the airway resistance] (PubMed id 15069780)^{1, 4, 7} Yamasaki Y....Ueda N. (2004)
[beta 2-adrenoceptor polymorphism and effect of inhaled beta 2-stimulant (procaterol) on airway resistance measured by body plethysmography in healthy volunteers] (PubMed id 12428391)^{1, 4, 7} Kobayashi M....Taguchi H. (2002)
ADRB2 polymorphisms and asthma susceptibility: transmission disequilibrium test and meta-analysis. (PubMed id 15153795)^{1, 4, 9} Migita O....Arinami T. (2004)
Polymorphisms of IL4, IL13, and ADRB2 genes in COPD. (PubMed id 15596681)^{1, 4, 9} Hegab A.E....Sekizawa K. (2004)
Possible association of beta2- and beta3-adrenergic receptor gene polymorphisms with susceptibility to breast cancer. (PubMed id 11434877)^{1, 4, 9} Huang X.E....Tajima K. (2001)
Gln27Glu variant of the beta2-adrenergic receptor gene is not associated with obesity and diabetes in Japanese-Americans. (PubMed id 11288039)^{1, 4, 9} Kawamura T....Okubo M. (2001)
Pharmacogenetic differences in response to albuterol between Puerto Ricans and Mexicans with asthma. (PubMed id 15557128)^{1, 7, 9} Choudhry S....Burchard E.G. (2005)
[The genotype analysis of beta adrenergic receptor gene family in high risk population of hypertension in northeast China] (PubMed id 15079793)^{1, 4, 9} Liang Y....Shi J.P. (2004)

(in PubMed, OMIM, and NCBI Bookshelf)
About This Section

		AND	OR
Aliases
Disorders
Free Text

Query String		PubMed OMIM NCBI Bookshelf
	(Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
About This Section

Entrez Gene: 154	HGNC: 286	AceView: ADRB2	Ensembl:ENSG00000169252	euGenes: HUgn154
ECgene: ADRB2	Kegg: 154	H-InvDB: ADRB2

(According to HUGE)
About This Section

(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section

Name	Description
PharmGKB entry for ADRB2	Pharmacogenomics, SNPs, Pathways
GeneReviews	http://www.ncbi.nlm.nih.gov/sites/GeneTests/lab/gene/ADRB2
SeattleSNPs	http://pga.gs.washington.edu/data/adrb2/

Intellectual Property for ADRB2 gene
(Patent information from GeneIP, Licensable technologies from WIS Yeda, Salk, Tufts, IP news from LifeMap Sciences, Inc.)

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Patent Information for ADRB2 gene:
Search GeneIP for patents involving ADRB2

GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search

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adrenoceptor beta 2, surface

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ADRB2 Gene

adrenoceptor beta 2, surface

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