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Aliases for ADRB2 Gene

Aliases for ADRB2 Gene

  • Adrenoceptor Beta 2 2 3 5
  • Adrenergic, Beta-2-, Receptor, Surface 2 3
  • Beta-2 Adrenoreceptor 3 4
  • Beta-2 Adrenoceptor 3 4
  • ADRB2R 3 4
  • B2AR 3 4
  • Adrenoceptor Beta 2, Surface 2
  • Adrenoceptor Beta 2 Surface 3
  • Beta-2 Adrenergic Receptor 3
  • Catecholamine Receptor 3
  • BETA2AR 3
  • ADRBR 3
  • BAR 3

External Ids for ADRB2 Gene

Previous HGNC Symbols for ADRB2 Gene

  • ADRB2R

Previous GeneCards Identifiers for ADRB2 Gene

  • GC05P148250
  • GC05M148800
  • GC05P148187
  • GC05P148235
  • GC05P148236
  • GC05P148186
  • GC05P143352

Summaries for ADRB2 Gene

Entrez Gene Summary for ADRB2 Gene

  • This gene encodes beta-2-adrenergic receptor which is a member of the G protein-coupled receptor superfamily. This receptor is directly associated with one of its ultimate effectors, the class C L-type calcium channel Ca(V)1.2. This receptor-channel complex also contains a G protein, an adenylyl cyclase, cAMP-dependent kinase, and the counterbalancing phosphatase, PP2A. The assembly of the signaling complex provides a mechanism that ensures specific and rapid signaling by this G protein-coupled receptor. This gene is intronless. Different polymorphic forms, point mutations, and/or downregulation of this gene are associated with nocturnal asthma, obesity and type 2 diabetes. [provided by RefSeq, Jul 2008]

GeneCards Summary for ADRB2 Gene

ADRB2 (Adrenoceptor Beta 2) is a Protein Coding gene. Diseases associated with ADRB2 include Asthma and Obesity. Among its related pathways are Signaling by GPCR and Development Ligand-independent activation of ESR1 and ESR2. GO annotations related to this gene include G-protein coupled receptor activity and enzyme binding. An important paralog of this gene is ADRB1.

UniProtKB/Swiss-Prot for ADRB2 Gene

  • Beta-adrenergic receptors mediate the catecholamine-induced activation of adenylate cyclase through the action of G proteins. The beta-2-adrenergic receptor binds epinephrine with an approximately 30-fold greater affinity than it does norepinephrine.

Tocris Summary for ADRB2 Gene

  • The adrenergic beta2 receptor (beta2-adrenoceptor) is a member of the adrenergic receptor group of G-protein-coupled receptors that also includes alpha1A, alpha1B, alpha1D, alpha2A, alpha2B, alpha2C, beta1 and beta3. They are located primarily in the CNS, heart, kidney and muscle.

Gene Wiki entry for ADRB2 Gene

PharmGKB "VIP" Summary for ADRB2 Gene

No data available for fRNAdb sequence ontologies and piRNA Summary for ADRB2 Gene

Genomics for ADRB2 Gene

Regulatory Elements for ADRB2 Gene

Enhancers for ADRB2 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH05F148792 1 FANTOM5 Ensembl 21.3 -31.0 -31045 3.2 JUND GATA3 SCRT2 FOS ATF2 NFE2L2 ADRB2 LOC255187 MIR584 SH3TC2 RNU6-732P FBXO38 GC05M148692
GH05F148789 1 FANTOM5 Ensembl ENCODE 20.1 -34.1 -34051 2.5 TBL1XR1 ZMYM3 BMI1 RELA EED ZNF143 ETV6 FOS CREM MTA2 ADRB2 FBXO38 GC05M148692
GH05F148971 1.2 FANTOM5 Ensembl ENCODE 18 +148.4 148420 3.6 GTF2F1 CTCF MXI1 TAF1 JUN MAX SIN3A RAD21 GTF3C2 E2F1 ADRB2 ENSG00000251330 SH3TC2 ENSG00000272411 GC05M148982
GH05F148841 1.2 FANTOM5 Ensembl ENCODE 17.3 +21.2 21159 10.2 CTCF PKNOX1 TAF1 RAD21 YY1 HIC1 ZNF316 GATA3 ZNF366 SCRT2 ADRB2 ENSG00000251330 ABLIM3 ARHGEF37 ENSG00000272411
GH05F148964 1.5 FANTOM5 Ensembl ENCODE 16.3 +142.8 142755 6.4 PKNOX1 ZBTB40 RAD21 SCRT2 SMARCC2 RCOR1 FOS SMARCC1 CEBPB USF2 ADRB2 SH3TC2 LOC255187 ENSG00000272411
- Elite enhancer/Elite enhancer-gene association Download Table
Download GeneHancer data dump

Enhancers around ADRB2 on UCSC Golden Path with GeneCards custom track

Genomic Location for ADRB2 Gene

Chromosome:
5
Start:
148,825,245 bp from pter
End:
148,828,687 bp from pter
Size:
3,443 bases
Orientation:
Plus strand

Genomic View for ADRB2 Gene

Genes around ADRB2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ADRB2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ADRB2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ADRB2 Gene

Proteins for ADRB2 Gene

  • Protein details for ADRB2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P07550-ADRB2_HUMAN
    Recommended name:
    Beta-2 adrenergic receptor
    Protein Accession:
    P07550
    Secondary Accessions:
    • B0LPE4
    • B2R7X2
    • O14823
    • O14824
    • O14825
    • O14826
    • Q4JG18
    • Q53GA6
    • Q6GMT4
    • Q6P4D8
    • Q8NEQ9
    • Q96EC3
    • Q9UCZ0
    • Q9UCZ1
    • Q9UCZ2
    • Q9UCZ3
    • Q9UH95
    • Q9UHA1
    • Q9UMZ5

    Protein attributes for ADRB2 Gene

    Size:
    413 amino acids
    Molecular mass:
    46459 Da
    Quaternary structure:
    • Binds SLC9A3R1 and GPRASP1. Interacts with ARRB1 and ARRB2. Interacts with SRC, USP20 and USP33. Interacts with VHL; the interaction, which is increased on hydroxylation of ADRB2, ubiquitinates ADRB2 leading to its degradation. Interacts with EGLN3; the interaction hydroxylates ADRB2 facilitating VHL-E3 ligase-mediated ubiquitination. Interacts (via PDZ-binding motif) with SNX27 (via PDZ domain); the interaction is required when endocytosed to prevent degradation in lysosomes and promote recycling to the plasma membrane. Interacts with CNIH4 (PubMed:24405750). Interacts with ARRDC3 (PubMed:20559325, PubMed:25220262).
    SequenceCaution:
    • Sequence=BAD96745.1; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for ADRB2 Gene

neXtProt entry for ADRB2 Gene

Post-translational modifications for ADRB2 Gene

  • Hydroxylation by EGLN3 occurs only under normoxia and increases the interaction with VHL and the subsequent ubiquitination and degradation of ADRB2.
  • Palmitoylated; may reduce accessibility of Ser-345 and Ser-346 by anchoring Cys-341 to the plasma membrane. Agonist stimulation promotes depalmitoylation and further allows Ser-345 and Ser-346 phosphorylation.
  • Phosphorylated by PKA and BARK upon agonist stimulation, which mediates homologous desensitization of the receptor. PKA-mediated phosphorylation seems to facilitate phosphorylation by BARK.
  • Phosphorylation of Tyr-141 is induced by insulin and leads to supersensitization of the receptor.
  • Polyubiquitinated. Agonist-induced ubiquitination leads to sort internalized receptors to the lysosomes for degradation (PubMed:19424180, PubMed:20559325). Deubiquitination by USP20 and USP33, leads to ADRB2 recycling and resensitization after prolonged agonist stimulation. USP20 and USP33 are constitutively associated and are dissociated immediately after agonist stimulation. Ubiquitination by the VHL-E3 ligase complex is oxygen-dependent.
  • Glycosylation at Asn 6 and Asn 15
  • Modification sites at PhosphoSitePlus

Other Protein References for ADRB2 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for ADRB2 Gene

Domains & Families for ADRB2 Gene

Gene Families for ADRB2 Gene

Suggested Antigen Peptide Sequences for ADRB2 Gene

Graphical View of Domain Structure for InterPro Entry

P07550

UniProtKB/Swiss-Prot:

ADRB2_HUMAN :
  • Belongs to the G-protein coupled receptor 1 family. Adrenergic receptor subfamily. ADRB2 sub-subfamily.
Family:
  • Belongs to the G-protein coupled receptor 1 family. Adrenergic receptor subfamily. ADRB2 sub-subfamily.
genes like me logo Genes that share domains with ADRB2: view

Function for ADRB2 Gene

Molecular function for ADRB2 Gene

GENATLAS Biochemistry:
adrenergic,beta-2-,receptor,G protein coupled receptor superfamily,activating adenylate cyclase,major lipolytic receptor in human fat cell altered in obesity,also associated to susceptibility to hypertension (polymorphism,R16G)
UniProtKB/Swiss-Prot Function:
Beta-adrenergic receptors mediate the catecholamine-induced activation of adenylate cyclase through the action of G proteins. The beta-2-adrenergic receptor binds epinephrine with an approximately 30-fold greater affinity than it does norepinephrine.

Gene Ontology (GO) - Molecular Function for ADRB2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004871 signal transducer activity IEA --
GO:0004930 G-protein coupled receptor activity IEA --
GO:0004935 adrenergic receptor activity IEA --
GO:0004941 beta2-adrenergic receptor activity IEA,IDA 15123695
GO:0005515 protein binding IPI 9560162
genes like me logo Genes that share ontologies with ADRB2: view
genes like me logo Genes that share phenotypes with ADRB2: view

Animal Models for ADRB2 Gene

MGI Knock Outs for ADRB2:

Animal Model Products

miRNA for ADRB2 Gene

miRTarBase miRNAs that target ADRB2

Inhibitory RNA Products

Clone Products

  • Addgene plasmids for ADRB2
  • R&D Systems cDNA Clones for ADRB2 (beta-2 Adrenergic R/ADRB2)

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for ADRB2 Gene

Localization for ADRB2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ADRB2 Gene

Cell membrane; Multi-pass membrane protein. Early endosome. Note=Colocalizes with VHL at the cell membrane (PubMed:19584355). Activated receptors are internalized into endosomes prior to their degradation in lysosomes (PubMed:20559325). {ECO:0000269 PubMed:19584355, ECO:0000269 PubMed:20559325}.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for ADRB2 Gene COMPARTMENTS Subcellular localization image for ADRB2 gene
Compartment Confidence
endosome 5
lysosome 5
plasma membrane 5
vacuole 5
extracellular 3
nucleus 3
cytoskeleton 2
endoplasmic reticulum 2
cytosol 1
mitochondrion 1

Gene Ontology (GO) - Cellular Components for ADRB2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IEA --
GO:0005764 lysosome TAS 9507004
GO:0005768 endosome IEA,TAS 10734107
GO:0005769 early endosome IEA --
GO:0005886 plasma membrane IEA,TAS --
genes like me logo Genes that share ontologies with ADRB2: view

Pathways & Interactions for ADRB2 Gene

genes like me logo Genes that share pathways with ADRB2: view

SIGNOR curated interactions for ADRB2 Gene

Activates:
Is inactivated by:

Gene Ontology (GO) - Biological Process for ADRB2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0002024 diet induced thermogenesis IEA --
GO:0002025 vasodilation by norepinephrine-epinephrine involved in regulation of systemic arterial blood pressure IBA --
GO:0002028 regulation of sodium ion transport IEA --
GO:0002032 desensitization of G-protein coupled receptor protein signaling pathway by arrestin IDA 15123695
GO:0006898 receptor-mediated endocytosis IDA 15123695
genes like me logo Genes that share ontologies with ADRB2: view

Drugs & Compounds for ADRB2 Gene

(217) Drugs for ADRB2 Gene - From: DrugBank, PharmGKB, ApexBio, DGIdb, FDA Approved Drugs, IUPHAR, HMDB, Tocris, and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Isoproterenol Approved Pharma Full agonist, Agonist, agonist, Target 21
Carvedilol Approved, Investigational Pharma Antagonist, antagonist, Target 163
Betaxolol Approved Pharma Antagonist, antagonist, Target βadrenergic receptor blocker 6
Propranolol Approved, Investigational Pharma Antagonist, antagonist, Target Beta blocker 216
Salbutamol Approved, Vet_approved Pharma Partial agonist, Agonist, agonist, Target 0

(42) Additional Compounds for ADRB2 Gene - From: Novoseek, Tocris, and HMDB

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
8-Hydroxycarvedilol
Salbutamol hemisulfate
51022-70-9

(5) Tocris Compounds for ADRB2 Gene

Compound Action Cas Number
Formoterol hemifumarate Potent and selective beta2 agonist 43229-80-7
ICI 118,551 hydrochloride Very selective beta2 antagonist 72795-01-8
Procaterol hydrochloride Potent beta2 agonist 62929-91-3
Salbutamol hemisulfate beta agonist (beta2 > beta1) 51022-70-9
Salmeterol xinafoate Long-acting beta2 agonist; bronchodilator 94749-08-3

(56) ApexBio Compounds for ADRB2 Gene

Compound Action Cas Number
(R,R)-Formoterol β2-selective adrenergic agonist 67346-49-0
Acebutolol HCl 34381-68-5
Adrenalone HCl 62-13-5
Bambuterol 81732-65-2
Betaxolol βadrenergic receptor blocker 659-18-7
Betaxolol HCl 63659-19-8
Bisoprolol fumarate 104344-23-2
Carteolol HCl Non-selective beta-adrenoceptor antagonist 51781-21-6
Carvedilol 72956-09-3
CGP 12177 hydrochloride β1/β2-AR antagonist,β3 AR partial agonist 64208-32-8
Cisatracurium Besylate Neuromuscular-blocking drug 96946-42-8
Clonidine HCl 4205-91-8
Clorprenaline HCL 6933-90-0
Detomidine HCl 90038-01-0
Dexmedetomidine 113775-47-6
Dexmedetomidine HCl 145108-58-3
DL-Adrenaline 329-65-7
Epinephrine Bitartrate 51-42-3
Epinephrine HCl 55-31-2
Esmolol HCl 81161-17-3
Formoterol Hemifumarate 43229-80-7
Guanabenz Acetate 23256-50-0
HOKU-81 Bronchodilators,metabolite of tulobuterol 58020-43-2
ICI 118,551 hydrochloride 72795-01-8
Indacaterol β2-agonist 312753-06-3
Indacaterol Maleate 753498-25-8
Isoprenaline HCl 51-30-9
Ivabradine HCl 148849-67-6
Labetalol HCl 32780-64-6
L-Adrenaline 51-43-4
Levobetaxolol HCl 116209-55-3
Maprotiline HCl 10347-81-6
Medetomidine HCl 86347-15-1
Methyldopa 555-30-6
Mirabegron (YM178) 223673-61-8
Naftopidil DiHCl 57149-08-3
Naphazoline HCl 550-99-2
Nebivolol 152520-56-4
Nedaplatin 95734-82-0
Phenoxybenzamine HCl 63-92-3
Phenylephrine HCl 61-76-7
Propranolol HCl 318-98-9
Ritodrine HCl β-2 adrenergic receptor agonist 23239-51-2
Salbutamol Sulfate β-2 adrenergic receptor agonist 51022-70-9
Salmeterol xinafoate β2-adrenergic receptor agonist 94749-08-3
Scopine 498-45-3
Sotalol hydrochloride β-adrenergic receptor antagonist 959-24-0
Synephrine HCl 5985-28-4
Terazosin HCl 70024-40-7
Terbutaline Sulfate 23031-32-5
Tetrahydrozoline HCl 522-48-5
Timolol Maleate 26921-17-5
Tizanidine HCl 64461-82-1
Tolazoline HCl 59-97-2
Vilanterol β2-AR agonist 503068-34-6
Vilanterol trifenatate β2-AR agonist 503070-58-4
genes like me logo Genes that share compounds with ADRB2: view

Drug Products

Transcripts for ADRB2 Gene

mRNA/cDNA for ADRB2 Gene

(1) REFSEQ mRNAs :
(8) Additional mRNA sequences :
(50) Selected AceView cDNA sequences:
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for ADRB2 Gene

Adrenoceptor beta 2, surface:
Representative Sequences:

Inhibitory RNA Products

Clone Products

  • Addgene plasmids for ADRB2
  • R&D Systems cDNA Clones for ADRB2 (beta-2 Adrenergic R/ADRB2)

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for ADRB2 Gene

No ASD Table

Relevant External Links for ADRB2 Gene

GeneLoc Exon Structure for
ADRB2
ECgene alternative splicing isoforms for
ADRB2

Expression for ADRB2 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for ADRB2 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for ADRB2 Gene

This gene is overexpressed in Skin - Not Sun Exposed (Suprapubic) (x5.4) and Skin - Sun Exposed (Lower leg) (x4.8).

Protein differential expression in normal tissues from HIPED for ADRB2 Gene

This gene is overexpressed in Placenta (69.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for ADRB2 Gene



Protein tissue co-expression partners for ADRB2 Gene

NURSA nuclear receptor signaling pathways regulating expression of ADRB2 Gene:

ADRB2

SOURCE GeneReport for Unigene cluster for ADRB2 Gene:

Hs.2551
genes like me logo Genes that share expression patterns with ADRB2: view

Primer Products

No data available for mRNA Expression by UniProt/SwissProt for ADRB2 Gene

Orthologs for ADRB2 Gene

This gene was present in the common ancestor of animals.

Orthologs for ADRB2 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia ADRB2 34 35
  • 99.6 (n)
dog
(Canis familiaris)
Mammalia ADRB2 34 35
  • 90 (n)
cow
(Bos Taurus)
Mammalia ADRB2 34 35
  • 89.99 (n)
rat
(Rattus norvegicus)
Mammalia Adrb2 34
  • 87.09 (n)
mouse
(Mus musculus)
Mammalia Adrb2 34 16 35
  • 85.71 (n)
oppossum
(Monodelphis domestica)
Mammalia ADRB2 35
  • 78 (a)
OneToOne
chicken
(Gallus gallus)
Aves ADRB2 34
  • 78.16 (n)
lizard
(Anolis carolinensis)
Reptilia ADRB2 35
  • 65 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia adrb2 34
  • 67.43 (n)
African clawed frog
(Xenopus laevis)
Amphibia MGC68724 34
zebrafish
(Danio rerio)
Actinopterygii adrb2b 34 35
  • 62.98 (n)
adrb2a 35
  • 54 (a)
OneToMany
African malaria mosquito
(Anopheles gambiae)
Insecta GPRNNA2 34
  • 51.13 (n)
fruit fly
(Drosophila melanogaster)
Insecta Octbeta2R 34 35
  • 50.3 (n)
DopR2 36
  • 45 (a)
CG6989 36
  • 40 (a)
CG6919 36
  • 39 (a)
DopR 36
  • 33 (a)
oa2 35
  • 25 (a)
ManyToMany
worm
(Caenorhabditis elegans)
Secernentea M03F4.3 36
  • 34 (a)
Species where no ortholog for ADRB2 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for ADRB2 Gene

ENSEMBL:
Gene Tree for ADRB2 (if available)
TreeFam:
Gene Tree for ADRB2 (if available)

Paralogs for ADRB2 Gene

Paralogs for ADRB2 Gene

genes like me logo Genes that share paralogs with ADRB2: view

Variants for ADRB2 Gene

Polymorphic Variants from UniProtKB/Swiss-Prot for ADRB2 Gene

ADRB2_HUMAN-P07550
The Gly-16 allele is overrepresented in individuals affected by nocturnal asthma as compared to controls, and appears to be an important genetic factor in the expression of this asthmatic phenotype.

Sequence variations from dbSNP and Humsavar for ADRB2 Gene

SNP ID Clin Chr 05 pos Sequence Context AA Info Type
rs1042713 drug-response 148,826,877(+) CCAAT(A/G)GAAGC reference, missense
rs1800888 drug-response 148,827,322(+) CCTTA(C/T)CTCCT reference, missense
rs1042714 other 148,826,910(+) CGCAG(C/G)AAAGG reference, missense
rs1042711 -- 148,826,785(+) CCGCC(C/T)GCTGA utr-variant-5-prime
rs1042717 -- 148,827,083(+) GGCCT(A/G)GCAGT reference, synonymous-codon

Structural Variations from Database of Genomic Variants (DGV) for ADRB2 Gene

Variant ID Type Subtype PubMed ID
nsv599947 CNV loss 21841781

Variation tolerance for ADRB2 Gene

Residual Variation Intolerance Score: 29.6% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 9.34; 88.36% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for ADRB2 Gene

Human Gene Mutation Database (HGMD)
ADRB2
SNPedia medical, phenotypic, and genealogical associations of SNPs for
ADRB2

Disorders for ADRB2 Gene

MalaCards: The human disease database

(26) MalaCards diseases for ADRB2 Gene - From: OMIM, ClinVar, GeneTests, DISEASES, Novoseek, and GeneCards

Disorder Aliases PubMed IDs
asthma
  • asthma, protection against
obesity
  • obesity, association with
asthma susceptibility, adrb2-related
  • asthma, nocturnal, susceptibility to
obesity susceptibility, adrb2-related
  • obesity, susceptibility to
status asthmaticus
  • asthma with status asthmaticus
- elite association - COSMIC cancer census association via MalaCards
Search ADRB2 in MalaCards View complete list of genes associated with diseases

Relevant External Links for ADRB2

Genetic Association Database (GAD)
ADRB2
Human Genome Epidemiology (HuGE) Navigator
ADRB2
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
ADRB2
genes like me logo Genes that share disorders with ADRB2: view

No data available for UniProtKB/Swiss-Prot and Genatlas for ADRB2 Gene

Publications for ADRB2 Gene

  1. Adrenergic receptor polymorphisms and platelet reactivity after treatment with dual antiplatelet therapy with aspirin and clopidogrel in acute coronary syndrome. (PMID: 20135061) Cuisset T. … Barbato E. (Thromb. Haemost. 2010) 3 22 46 64
  2. Role of beta-adrenergic receptor gene polymorphisms in the long-term effects of beta-blockade with carvedilol in patients with chronic heart failure. (PMID: 20352314) Metra M. … Dei Cas L. (Cardiovasc Drugs Ther 2010) 3 22 46 64
  3. GSNO reductase and beta2-adrenergic receptor gene-gene interaction: bronchodilator responsiveness to albuterol. (PMID: 20335826) Choudhry S. … Burchard E.G. (Pharmacogenet. Genomics 2010) 3 22 46 64
  4. Beta2-adrenergic receptor polymorphisms affect response to treatment in children with severe asthma exacerbations. (PMID: 19029431) Carroll C.L. … Zucker A.R. (Chest 2009) 3 22 46 64
  5. Beta 2-adrenergic polymorphisms and total serum IgE levels in children with asthma from Argentina. (PMID: 19441602) Giubergia V. … Chertkoff L. (Ann. Allergy Asthma Immunol. 2009) 3 22 46 64

Products for ADRB2 Gene

Sources for ADRB2 Gene

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