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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

ADRB2 Gene

protein-coding   GIFtS: 71
GCID: GC05P148186

Adrenoceptor Beta 2, Surface

(Previous names: adrenergic, beta-2-, receptor, surface)
(Previous symbol: ADRB2R)
Microbiology & Infectious Diseases Congress
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
Adrenoceptor Beta 2, Surface1 2     ADRBR2
ADRB2R1 2 3     BAR2
Adrenergic, Beta-2-, Receptor, Surface1 2     BETA2AR2
Beta-2 Adrenoceptor2 3     Beta-2 Adrenergic Receptor2
Beta-2 Adrenoreceptor2 3     Catecholamine Receptor2
B2AR2 3     

External Ids:    HGNC: 2861   Entrez Gene: 1542   Ensembl: ENSG000001692527   OMIM: 1096905   UniProtKB: P075503   

Export aliases for ADRB2 gene to outside databases

Previous GC identifers: GC05P148250 GC05M148800 GC05P148187 GC05P148235 GC05P148236 GC05P143352


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for ADRB2 Gene:
This gene encodes beta-2-adrenergic receptor which is a member of the G protein-coupled receptor superfamily. This
receptor is directly associated with one of its ultimate effectors, the class C L-type calcium channel Ca(V)1.2.
This receptor-channel complex also contains a G protein, an adenylyl cyclase, cAMP-dependent kinase, and the
counterbalancing phosphatase, PP2A. The assembly of the signaling complex provides a mechanism that ensures
specific and rapid signaling by this G protein-coupled receptor. This gene is intronless. Different polymorphic
forms, point mutations, and/or downregulation of this gene are associated with nocturnal asthma, obesity and type
2 diabetes. (provided by RefSeq, Jul 2008)

GeneCards Summary for ADRB2 Gene: 
ADRB2 (adrenoceptor beta 2, surface) is a protein-coding gene. Diseases associated with ADRB2 include asthma, and status asthmaticus, and among its related super-pathways are Class A/1 (Rhodopsin-like receptors) and Amine ligand-binding receptors. GO annotations related to this gene include adenylate cyclase binding and protein homodimerization activity. An important paralog of this gene is HTR6.

UniProtKB/Swiss-Prot: ADRB2_HUMAN, P07550
Function: Beta-adrenergic receptors mediate the catecholamine-induced activation of adenylate cyclase through the
action of G proteins. The beta-2-adrenergic receptor binds epinephrine with an approximately 30-fold greater
affinity than it does norepinephrine

summary for ADRB2 Gene:
The adrenergic beta2 receptor (beta2-adrenoceptor) is a member of the adrenergic receptor group of
G-protein-coupled receptors that also includes alpha1A, alpha1B, alpha1D, alpha2A, alpha2B, alpha2C, beta1
and beta3. They are located primarily in the CNS, heart, kidney and muscle where they are involved in smooth
muscle relaxation (e.g. bronchodilation). The human adrenergic beta2 receptor gene has been localized to
chromosome 5 (5q31-q32).

Gene Wiki entry for ADRB2 (Beta-2 adrenergic receptor) Gene

PharmGKB "VIP" summary for ADRB2


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000005.9  NT_029289.11  NC_018916.2  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the ADRB2 gene promoter:
         CREB   p53   deltaCREB   STAT3   MyoD   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmids (see all 2): ADRB2 promoter sequence
   Search SABiosciences Chromatin IP Primers for ADRB2

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat ADRB2


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 5q31-q32   Ensembl cytogenetic band:  5q32   HGNC cytogenetic band: 5q31-q32

ADRB2 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
ADRB2 gene location

GeneLoc information about chromosome 5         GeneLoc Exon Structure

GeneLoc location for GC05P148186:  view genomic region     (about GC identifiers)

Start:
148,206,156 bp from pter      End:
148,208,197 bp from pter
Size:
2,042 bases      Orientation:
plus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: ADRB2_HUMAN, P07550 (See protein sequence)
Recommended Name: Beta-2 adrenergic receptor  
Size: 413 amino acids; 46459 Da
Subunit: Binds SLC9A3R1 and GPRASP1. Interacts with ARRB1 and ARRB2. Interacts with SRC, USP20 and USP33.
Interacts with VHL; the interaction, which is increased on hydroxylation of ADRB2, ubiquitinates ADRB2 leading to
its degradation. Interacts with EGLN3; the interaction hydroxylates ADRB2 facilitating VHL-E3 ligase-mediated
ubiquitination. Interacts (via PDZ-binding motif) with SNX27 (via PDZ domain); the interaction is required when
endocytosed to prevent degradation in lysosomes and promote recycling to the plasma membrane
Subcellular location: Cell membrane; Multi-pass membrane protein. Note=Colocalizes with VHL at the cell membrane
Sequence caution: Sequence=BAD96745.1; Type=Erroneous initiation; Note=Translation N-terminally shortened;
6/13 PDB 3D structures from and Proteopedia for ADRB2 (see all 13):
1GQ4 (3D)        2R4R (3D)        2R4S (3D)        2RH1 (3D)        3D4S (3D)        3KJ6 (3D)    
Secondary accessions: B0LPE4 B2R7X2 O14823 O14824 O14825 O14826 Q4JG18 Q53GA6 Q6GMT4 Q6P4D8
Q8NEQ9 Q96EC3 Q9UCZ0 Q9UCZ1 Q9UCZ2 Q9UCZ3 Q9UH95 Q9UHA1 Q9UMZ5

Explore the universe of human proteins at neXtProt for ADRB2: NX_P07550

Explore proteomics data for ADRB2 at MOPED 

Post-translational modifications:

  • UniProtKB: Palmitoylated; may reduce accessibility of Ser-345 and Ser-346 by anchoring Cys-341 to the plasma membrane.
    Agonist stimulation promotes depalmitoylation and further allows Ser-345 and Ser-346 phosphorylation
  • UniProtKB: Phosphorylated by PKA and BARK upon agonist stimulation, which mediates homologous desensitization of the
    receptor. PKA-mediated phosphorylation seems to facilitate phosphorylation by BARK
  • UniProtKB: Phosphorylation of Tyr-141 is induced by insulin and leads to supersensitization of the receptor
  • UniProtKB: Polyubiquitinated. Agonist-induced ubiquitination leads to sort internalized receptors to the lysosomes for
    degradation. Deubiquitination by USP20 and USP33, leads to ADRB2 recycling and resensitization after prolonged
    agonist stimulation. USP20 and USP33 are constitutively associated and are dissociated immediately after agonist
    stimulation. Ubiquitination by the VHL-E3 ligase complex is oxygen-dependent
  • UniProtKB: Hydroxylation by EGLN3 occurs only under normoxia and increases the interaction with VHL and the subsequent
    ubiquitination and degradation of ADRB2
  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_P07550

  • ADRB2 Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    ADRB2 Protein Expression
    REFSEQ proteins: NP_000015.1  
    ENSEMBL proteins: 
     ENSP00000305372  
    Reactome Protein details: P07550
    Human Recombinant Protein Products for ADRB2: 
    Browse Purified and Recombinant Proteins at EMD Millipore
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    OriGene Protein Over-expression Lysate for ADRB2
    OriGene Custom MassSpec 
    OriGene Custom Protein Services for ADRB2
    GenScript Custom Purified and Recombinant Proteins Services for ADRB2
    Novus Biologicals ADRB2 Protein
    Novus Biologicals ADRB2 Lysates
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates 
    Browse ProSpec Recombinant Proteins
    Browse Proteins at Cloud-Clone Corp. 

    Gene Ontology (GO): 5/9 cellular component terms (GO ID links to tree view) (see all 9):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus IEA--
    GO:0005764lysosome TAS9507004
    GO:0005768endosome TAS10734107
    GO:0005886plasma membrane TAS--
    GO:0005887integral to plasma membrane IDA12297500

    ADRB2 for ontologies           About GeneDecksing



    ADRB2 Antibody Products: 
    EMD Millipore Mono- and Polyclonal Antibodies for the study of ADRB2
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    Assay Products for ADRB2: 
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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    HGNC Gene Families: 
    ADRB: GPCR / Class A : Adrenoceptors : beta

    IUPHAR Guide to PHARMACOLOGY protein family classification: β2-adrenoceptor 
    Adrenoceptors

    4 InterPro protein domains:
     IPR017452 GPCR_Rhodpsn_7TM
     IPR002233 Adrnrgc_rcpt
     IPR000276 GPCR_Rhodpsn
     IPR000332 Adrgc_rcpt_B2

    Graphical View of Domain Structure for InterPro Entry P07550

    ProtoNet protein and cluster: P07550

    2 Blocks protein domains:
    IPB000332 Beta-2 adrenergic receptor signature
    IPB002233 Adrenergic receptor signature


    UniProtKB/Swiss-Prot: ADRB2_HUMAN, P07550
    Similarity: Belongs to the G-protein coupled receptor 1 family. Adrenergic receptor subfamily. ADRB2 sub-subfamily


    ADRB2 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: ADRB2_HUMAN, P07550
    Function: Beta-adrenergic receptors mediate the catecholamine-induced activation of adenylate cyclase through the
    action of G proteins. The beta-2-adrenergic receptor binds epinephrine with an approximately 30-fold greater
    affinity than it does norepinephrine

         Genatlas biochemistry entry for ADRB2:
    adrenergic,beta-2-,receptor,G protein coupled receptor superfamily,activating adenylate cyclase,major lipolytic
    receptor in human fat cell altered in obesity,also associated to susceptibility to hypertension
    (polymorphism,R16G)

         Gene Ontology (GO): 5/7 molecular function terms (GO ID links to tree view) (see all 7):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0004930G-protein coupled receptor activity ----
    GO:0004941beta2-adrenergic receptor activity IDA15123695
    GO:0005515protein binding IPI15123695
    GO:0008179adenylate cyclase binding IEA--
    GO:0015459potassium channel regulator activity IDA12297500
         
    ADRB2 for ontologies           About GeneDecksing


    Phenotypes:
         2 GenomeRNAi human phenotypes for ADRB2:
     Decreased G3BP1 protein expres  Large nuclei 

         12 MGI mutant phenotypes (inferred from 3 alleles(MGI details for Adrb2):
     adipose tissue  behavior/neurological  cardiovascular system  cellular  endocrine/exocrine gland 
     growth/size  hematopoietic system  homeostasis/metabolism  immune system  muscle 
     no phenotypic analysis  skeleton 

    ADRB2 for phenotypes           About GeneDecksing

    Animal Models:
         MGI mouse knock-out Adrb2tm1Bkk for ADRB2

       inGenious Targeting Laboratory - Custom generated mouse model solutions for ADRB2 
       inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for ADRB2

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for ADRB2 
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for ADRB2 

    miRNA
    Products:
        
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat ADRB2
    8/10 QIAGEN miScript miRNA Assays for microRNAs that regulate ADRB2 (see all 10):
    hsa-miR-98 hsa-let-7d hsa-let-7c hsa-let-7i hsa-miR-1284 hsa-let-7g hsa-let-7e hsa-let-7b
    SwitchGear 3'UTR luciferase reporter plasmidADRB2 3' UTR sequence
    Inhib. RNA
    Products:
        
    Browse for Gene Knock-down Tools from EMD Millipore
    OriGene RNAi products in human, mouse, rat for ADRB2
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat ADRB2

    Gene Editing
    Products:
    DNA2.0 Custom Protein Engineering Service for ADRB2
    Sirion Biotech Customized adenovirus for overexpression of ADRB2

    Clone
    Products:
         
    Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
    OriGene clones in human, mouse for ADRB2 (see all 7)
    OriGene ORF clones in mouse, rat for ADRB2
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: ADRB2 (NM_000024)
    Sino Biological Human cDNA Clone for ADRB2
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for ADRB2
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat ADRB2
    Sirion Biotech Customized lentivirus for stable overexpression of ADRB2 
                         Customized lentivirus expression plasmids for stable overexpression of ADRB2 

    Cell Line
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    GenScript ADRB2-overexpressing Cell Line for Assay
    Search LifeMap BioReagents cell lines for ADRB2
    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ADRB2


    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section

    SuperPaths for ADRB2 About   (see all 23)                                                                                              See pathways by source

    SuperPathContained pathways About
    1Class A/1 (Rhodopsin-like receptors)
    Class A/1 (Rhodopsin-like receptors)0.71
    GPCRs, Class A Rhodopsin-like0.41
    GPCR ligand binding0.71
    Neuroactive ligand-receptor interaction0.37
    2Monoamine GPCRs
    Monoamine GPCRs0.79
    Amine ligand-binding receptors0.79
    3Adrenoceptors
    Adrenoceptors0.33
    Sympathetic Nerve Pathway (Neuroeffector Junction)0.33
    4PKA activation in glucagon signalling
    Beta-2 adrenergic-dependent CFTR expression0.74
    Development Beta-adrenergic receptors signaling via cAMP0.32
    5Signaling by GPCR
    Signaling by GPCR0.90
    Signal Transduction0.55
    GPCR downstream signaling0.90

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    4 EMD Millipore Pathways for ADRB2
        Development Beta-adrenergic receptors regulation of ERK
    Development Beta-adrenergic receptors signaling via cAMP
    Transcription CREB pathway
    Development Ligand-independent activation of ESR1 and ESR2

    5 Downloadable PowerPoint Slides of QIAGEN Pathway Central Maps for ADRB2
        Activation of PKA through GPCR
    cAMP Pathway
    Activation of cAMP-Dependent PKA
    Signaling Involved in Cardiac Hypertrophy
    Beta-Adrenergic Signaling

    2 Cell Signaling Technology (CST) Pathways for ADRB2
        Ca, cAMP and Lipid Signaling
    Neuroscience

    5/7 GeneGo (Thomson Reuters) Pathways for ADRB2 (see all 7)
        Development Ligand-independent activation of ESR1 and ESR2
    Development Beta-adrenergic receptors signaling via cAMP
    Beta-2 adrenergic-dependent CFTR expression
    Transcription CREB pathway
    Regulation of CFTR activity (norm and CF)

    5/6 BioSystems Pathways for ADRB2 (see all 6)
        Calcium Regulation in the Cardiac Cell
    GPCRs, Other
    GPCRs, Class A Rhodopsin-like
    Arf6 signaling events
    Arf6 trafficking events


    5/8        Reactome Pathways for ADRB2 (see all 8)
        GPCR downstream signaling
    Signaling by GPCR
    GPCR ligand binding
    Adrenoceptors
    Class A/1 (Rhodopsin-like receptors)

    3 PharmGKB Pathways for ADRB2
        Antiarrhythmic Pathway, Pharmacodynamics
    Beta-agonist/Beta-blocker Pathway, Pharmacodynamics
    Sympathetic Nerve Pathway (Neuroeffector Junction)

    4         Kegg Pathways  (Kegg details for ADRB2):
        Calcium signaling pathway
    Neuroactive ligand-receptor interaction
    Endocytosis
    Salivary secretion


    ADRB2 for pathways           About GeneDecksing

    Interactions:

        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for ADRB2

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    5/125 Interacting proteins for ADRB2 (P075502, 3 ENSP000003053724) via UniProtKB, MINT, STRING, and/or I2D (see all 125)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    MAGI3Q5TCQ92, 3, ENSP000003046044MINT-7716320 MINT-7716382 MINT-7716556 MINT-7716470 MINT-7716630 MINT-7716422 MINT-7716450 MINT-7716335 MINT-7716502 I2D: score=2 STRING: ENSP00000304604
    SLC9A3R1O147452, 3, ENSP000002626134MINT-1796489 MINT-2842955 MINT-1796525 MINT-2843018 MINT-2842994 MINT-1796656 MINT-2842879 MINT-2842917 I2D: score=6 STRING: ENSP00000262613
    ARRDC3Q96B672, 3, ENSP000002651384MINT-8430222 MINT-8430169 I2D: score=1 STRING: ENSP00000265138
    GRB2P629932, 3, ENSP000003390074MINT-8036983 I2D: score=4 STRING: ENSP00000339007
    LAMP2P134732, 3, ENSP000004084114MINT-7291650 I2D: score=1 STRING: ENSP00000408411
    About this table

    Gene Ontology (GO): 5/24 biological process terms (GO ID links to tree view) (see all 24):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0001993regulation of systemic arterial blood pressure by norepinephrine-epinephrine ----
    GO:0002024diet induced thermogenesis IEA--
    GO:0002025vasodilation by norepinephrine-epinephrine involved in regulation of systemic arterial blood pressure IEA--
    GO:0002028regulation of sodium ion transport IEA--
    GO:0002032desensitization of G-protein coupled receptor protein signaling pathway by arrestin IDA15123695

    ADRB2 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section

    ADRB2 for compounds           About GeneDecksing

    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Compounds for ADRB2 available from Tocris Bioscience    About this table
    CompoundAction CAS #
    ICI 118,551 hydrochloride Very selective beta2 antagonist[72795-01-8]
    Salmeterol xinafoateLong-acting beta2 agonist; bronchodilator[94749-08-3]
    Procaterol hydrochloridePotent beta2 agonist[62929-91-3]
    Formoterol hemifumaratePotent and selective beta2 agonist[183814-30-4]
    Salbutamol hemisulfatebeta agonist (beta2 > beta1)[51022-70-9]

    5 HMDB Compounds for ADRB2    About this table
    CompoundSynonyms CAS #PubMed Ids
    Epinephrine(-)-(R)-Epinephrine (see all 72)51-43-4--
    Norepinephrine(-)-(R)-Norepinephrine (see all 32)51-41-2--
    PropranololDociton (see all 8)525-66-6--
    Pseudoephedrine(+)-(1S,2S)-Pseudoephedrine (see all 25)90-82-4--
    Salbutamol(l)-albuterol (see all 97)18559-94-9--

    10/48 DrugBank Compounds for ADRB2 (see all 48)    About this table
    CompoundSynonyms CAS #TypeActionsPubMed Ids
    FormoterolFormoterol fumarate (see all 2)73573-87-2targetagonist17594727 14720051 12090787 9506248 11752352 16432501 1718682 18686730 7675115 14662724 2544117
    TerbutalineTerbutalin (see all 5)23031-25-6targetagonist2062329 1358833 11675405 11752352 20674738 18782903 11256987 12569076 11120594 10226872
    Arformoterol-- 67346-49-0targetagonist17352511 17594727 20406080 16022567 18501650 14725487 11752352 17472819
    NorepinephrineArterenol (see all 4)51-41-2targetagonist18064417 9666280 9464897 17139284 17016423 19110970 7969507 11504801
    Bambuterol-- 81732-46-9targetagonist20012638 8885698 8223836 11752352 3262993 18065099 12065188
    IsoproterenolEpinephrine Isopropyl Homolog (see all 14)7683-59-2targetagonist12963495 15151902 14656380 10722 11752352 15105445 14752060
    LabetalolLabetalol HCL (see all 4)36894-69-6targetantagonist19879818 1361547 2907566 6355664 11752352 7684671 8104240
    LevobunololLevobunolol HCl (see all 2)47141-42-4targetantagonist6147147 7928182 2891463 11752352 2892662 1351412 11572462
    TimololTimolol maleate (see all 2)26839-75-8targetantagonist16205624 9730867 11752352 8103526 8719802 9088585 10592235
    Bopindolol-- 69010-88-4targetpartial agonist1687398 1678274 1979630 16574446 11752352 1666931

    10/30 IUPHAR Ligands for ADRB22-adrenoceptor) (see all 30)    About this table 
    LigandTypeActionAffinityPubmed IDs
    [125I]ICYP
    AntagonistAntagonist10.7 - 11.18982677 10079020
    formoterol
    AgonistAgonist10.0820590599
    carvedilol
    AntagonistAntagonist9.4 - 9.915655528 10411574
    timolol
    AntagonistAntagonist9.715655528
    ICI 118551
    AntagonistInverse agonist9.2 - 9.510079020 15655528 12920204
    propranolol
    AntagonistAntagonist9.1 - 9.515655528 12920204 10079020 10531390
    zinterol
    AgonistAgonist9.4820590599
    CGP 12177
    AntagonistAntagonist9.410079020 15655528
    SR59230A
    AntagonistAntagonist9.310411574
    bupranolol
    AntagonistAntagonist8.3 - 9.110079020 10411574

    10/116 Novoseek inferred chemical compound relationships for ADRB2 gene (see all 116)    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    isoproterenol 84.9 122 10510435 (4), 15178407 (3), 17885618 (3), 10840035 (3) (see all 67)
    zinterol 77.1 8 18467626 (2), 9915773 (2), 9872996 (1), 9884381 (1)
    salbutamol 76.8 51 20335826 (3), 9873044 (3), 15557128 (2), 15687340 (2) (see all 31)
    icyp 75 2 1352549 (1), 15110997 (1)
    terbutaline 74 38 12966369 (4), 16153394 (3), 17718540 (2), 12869379 (2) (see all 16)
    catecholamine 73.2 102 7608992 (3), 11591153 (3), 8756182 (2), 8685890 (2) (see all 72)
    carazolol 72.6 4 19353579 (1), 7601122 (1), 17962520 (1), 18821775 (1)
    salmeterol 72.4 40 9765503 (5), 16980556 (4), 17030231 (4), 8798639 (3) (see all 14)
    alprenolol 70.5 3 10822171 (1), 11041870 (1), 9494078 (1)
    butoxamine 69.2 12 15145612 (1), 16551744 (1), 16645459 (1), 15458278 (1) (see all 5)

    4 PharmGKB related drug/compound annotations for ADRB2 gene    About this table
    Drug/compound PharmGKB Annotation
    carvedilolCA  
    indacaterol
    salbutamolCA  
    salmeterolCA  

    Search CenterWatch for drugs/clinical trials and news about ADRB2

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for ADRB2 gene: 
    NM_000024.5  

    Unigene Cluster for ADRB2:

    Adrenoceptor beta 2, surface
    Hs.2551  [show with all ESTs]
    Unigene Representative Sequence: M15169
    1 Ensembl transcript including schematic representation, and UCSC links where relevant:
    ENST00000305988(uc003lpr.2)
    Congresses - knowledge worth sharing:  
    European Congress of Clinical Microbiology and Infectious Diseases (ECCMID) 10 - 13 May 2014

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    Additional mRNA sequence: 

    AK223025.1 AK313151.1 AY136741.1 BC012481.2 BC063486.1 BC073856.1 M15169.1 X04827.1 

    1 DOTS entry:

    DT.313911 

    24/50 AceView cDNA sequences (see all 50):

    BQ447101 BM544409 CR595085 BC073856 CA440083 AL553611 CN837362 BM702832 
    BC063486 AY136741 AV647785 BX092021 BI915042 M15169 BQ017003 AA948091 
    X04827 NM_000024 BP347785 BP366282 BC012481 BG256156 H90487 BI767868 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    ADRB2 expression in normal human tissues (normalized intensities)      ADRB2 embryonic expression: see
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: GACTCTTCCC
    ADRB2 Expression
    About this image


    ADRB2 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database 
     5/10 selected tissues (see all 10) fully expand
     
     Skeletal Muscle (Muscoskeletal System)    fully expand to see all 2 entries
             Mononuclear Myocytes Hyoid Arch Muscles
     
     Lung (Respiratory System)
             Human Small Airway Epithelial Cells (HSAEpiC)   
     
     Oral Cavity (Integumentary System)
             Human Oral Keritinocytes (HOK)   
     
     Ovary (Reproductive System)
             Cumulus Cells Antral Follicle
     
     Pancreas (Endocrine System)
             Duct Cells Pancreatic Ducts

    See ADRB2 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for ADRB2

    SOURCE GeneReport for Unigene cluster: Hs.2551
        SABiosciences Expression via Pathway-Focused PCR Arrays including ADRB2 (see all 7): 
              Neurotransmitter Receptors in human mouse rat
              G-Protein-Coupled Receptor Signaling PathwayFinder in human mouse rat
              G Protein Coupled Receptors 384HT in human mouse rat
              Skeletal Muscle: Myogenesis & Myopathy in human mouse rat
              Gap Junctions in human mouse rat

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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of animals.

    Orthologs for ADRB2 gene from 6/12 species (see all 12)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Adrb21 , 5 adrenergic receptor, beta 21, 5 85.71(n)1
    87.65(a)1
      18 (35.10 cM)5
    115551  NM_007420.21  NP_031446.21 
     621778175 
    chicken
    (Gallus gallus)
    Aves ADRB21 adrenergic, beta-2-, receptor, surface 78.47(n)
    80.27(a)
      427623  XM_425195.3  XP_425195.2 
    lizard
    (Anolis carolinensis)
    Reptilia ADRB26
    adrenoceptor beta 2, surface
    65(a)
    1 ↔ 1
    2(123276969-123335027)
    African clawed frog
    (Xenopus laevis)
    Amphibia MGC687242 hypothetical protein MGC68724 78.83(n)    BC060426.1 
    zebrafish
    (Danio rerio)
    Actinopterygii adrb2b1 adrenergic receptor, beta 2b 66.67(n)
    65.11(a)
      100037315  NM_001089471.1  NP_001082940.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta DopR23 dopamine receptor signaling pathway
    dopamine receptor
    45(a)
    (best of 4)
      3 99B5   --


    ENSEMBL Gene Tree for ADRB2 (if available)
    TreeFam Gene Tree for ADRB2 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for ADRB2 gene
    HTR62  TAAR22  TAAR92  TAAR82  HRH22  ADRA1A2  TAAR52  TAAR62  
    ADRB12  ADRA1B2  DRD12  TAAR12  HTR42  ADRB32  DRD52  ADRA1D2  
    18/26 SIMAP similar genes for ADRB2 using alignment to 2 protein entries:     ADRB2_HUMAN (see all proteins) (see all similar genes):
    5-HT7    ADRB1    ADRB3    DRD1    CHRM5    hA2aR
    DRD5    HRH3    HRH2    HTR4    TAAR1    TAAR9
    DRD5P1    HTR1D    HTR4B    TAAR8    ADRA1A    ADRA2C

    ADRB2 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    UniProtKB/Swiss-Prot: ADRB2_HUMAN, P07550
    Polymorphism: The Gly-16 allele is overrepresented in individuals affected by nocturnal asthma as compared to
    controls, and appears to be an important genetic factor in the expression of this asthmatic phenotype


    10/191 SNPs in ADRB2 are shown (see all 191)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 5 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs18008881,2,4
    C,F,Hdrug-response1148482492(+) CCTTAC/TCTCCT 2 T I mis1 trp318Minor allele frequency- T:0.01NS EA NA EU 12345
    rs10427131,2,4
    C,F,A,Hother1148482047(+) CCAATG/AGAAGC 2 /R /G mis159Minor allele frequency- A:0.42MN NS EA NA WA CSA EU 40166
    rs10427141,2,4
    C,F,A,Hother1148482080(+) CGCAGC/GAAAGG 2 Q E mis1 ese3 trp349Minor allele frequency- G:0.33MN NS EA NA WA CSA EU 38305
    VAR_0093944
    ----see VAR_0093942 K R mis40--------
    VAR_0091244
    ----see VAR_0091242 I L mis40--------
    VAR_0034544
    ----see VAR_0034542 V M mis40--------
    VAR_0091254
    ----see VAR_0091252 I F mis40--------
    rs455807321,2
    C,F--143354259(+) GACCC-/C/CCC/CCCC/CCCCC/CCCCCC/C
    CCCCCC
    /CCCCCCCC/CCCCCCCCC/G
    CCCCC
    9 -- ut31 cds11--2606
    rs1389258971,2
    F--143354265(+) CCCCC-/A/CAACAG 2 -- ut311NS 1862
    rs287639571,2
    C,F--148207662(+) AGACCA/C/GCCCCC 2 -- ut31 ese3 trp33NS EU 3933

    HapMap Linkage Disequilibrium report for ADRB2 (148206156 - 148208197 bp)

    Structural Variations
          Database of Genomic Variants (DGV) variations for ADRB2: --

    Human Gene Mutation Database (HGMD): ADRB2
    SABiosciences Cancer Mutation PCR Assays
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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    OMIM gene information: 109690   
    OMIM disorders: 600807  601665  
    20/140 diseases for ADRB2 (see all 140):    About MalaCards
    asthma    status asthmaticus    asthma, nocturnal    obesity
    resting heart rate    pain disorder    obesity, variation in    whim syndrome
    congenital aortic valve stenosis    aortic valve stenosis    aortic coarctation    thyrotoxic periodic paralysis
    acute mountain sickness    complex regional pain syndrome    orthostatic intolerance    obstructive lung disease
    hypokalemia    meningococcal infection    adult respiratory distress syndrome    syncope

    4 diseases from the University of Copenhagen DISEASES database for ADRB2:
    Asthma     Hypertension     Heart disease     Chronic obstructive pulmonary disease

    ADRB2 for disorders           About GeneDecksing


    Congresses - knowledge worth sharing:  
    Alzheimer's & Parkinson's Diseases Congress (ADPD) 18 - 22 March 2015

    10/93 Novoseek inferred disease relationships for ADRB2 gene (see all 93)    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    asthma 68.9 256 18156033 (5), 16357573 (5), 10374285 (5), 15153795 (5) (see all 99)
    status asthmaticus 42.2 4 16395068 (3), 12628991 (1)
    heart failure 39.4 22 17117186 (2), 11208703 (1), 14573333 (1), 18353108 (1) (see all 21)
    obesity 39.2 73 11288039 (5), 19779622 (5), 17907319 (3), 11016907 (3) (see all 31)
    essential hypertension 39 28 17963627 (2), 12361188 (2), 10981553 (2), 19102885 (2) (see all 13)
    cholera 36.7 4 10822171 (2), 10473590 (1), 17008315 (1)
    atopy 29 1 11941312 (1)
    pulmonary disease chronic obstructive 25.8 13 16463710 (1), 16861834 (1), 18667995 (1), 19293197 (1) (see all 11)
    lung diseases obstructive 25.4 2 19706446 (1), 18024720 (1)
    heart failure congestive 20.8 10 17361123 (3), 9788966 (1), 17336757 (1), 11392464 (1) (see all 7)

    Genetic Association Database (GAD): ADRB2
    Human Genome Epidemiology (HuGE) Navigator: ADRB2 (507 documents)

    Export disorders for ADRB2 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for ADRB2 gene, integrated from 9 sources (see all 1666):
    (articles sorted by number of sources associating them with ADRB2)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Pharmacogenetic differences in response to albuterol between Puerto Ricans and Mexicans with asthma. (PubMed id 15557128)1, 4, 7, 9 Choudhry S....Burchard E.G. (2005)
    2. Genetic polymorphisms of the beta 2-adrenergic receptor in nocturnal and nonnocturnal asthma. Evidence that Gly16 correlates with the nocturnal phenotype. (PubMed id 7706471)1, 2, 4, 9 Turki J.... Liggett S.B. (1995)
    3. Mutations in the gene encoding for the beta 2-adrenergic receptor in normal and asthmatic subjects. (PubMed id 8383511)1, 2, 4, 9 Reihsaus E.... Liggett S.B. (1993)
    4. [Beta 2-adrenoceptor polymorphism and effects of inhaled beta 2-stimulant (procaterol) and an anti-cholinergic drug (oxitropium) on the airway resistance] (PubMed id 15069780)1, 4, 7 Yamasaki Y....Ueda N. (2004)
    5. [beta 2-adrenoceptor polymorphism and effect of inhaled beta 2-stimulant (procaterol) on airway resistance measured by body plethysmography in healthy volunteers] (PubMed id 12428391)1, 4, 7 Kobayashi M....Taguchi H. (2002)
    6. Polymorphisms in the ADRB2 gene and Graves disease: a case-control study and a meta-analysis of available evidence. (PubMed id 19284637)1, 4, 9 Chu X....Huang W. (2009)
    7. {beta}2-Adrenergic Receptor Polymorphisms Affect Response to Treatment in Children With Severe Asthma Exacerbations. (PubMed id 19029431)1, 4, 9 Carroll C.L....Zucker A.R. (2008)
    8. No consistent effect of ADRB2 haplotypes on obesity, hypertension and quantitative traits of body fatness and blood pressure among 6 ,514 adult Danes. (PubMed id 19779622)1, 4, 9 Gjesing A.P....Olsen N.V. (2009)
    9. Polymorphism of the ADRB2 gene and response to inhale d beta- agonists in children with asthma: a meta-analysis. (PubMed id 19905915)1, 4, 9 Finkelstein Y....Shannon M. (2009)
    10. Combination of polymorphisms in the beta2-adrenergic receptor and nitric oxide synthase 3 genes increases the risk for hypertension. (PubMed id 19373110)1, 4, 9 Misono M....Ajisaka R. (2009)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 154 HGNC: 286 AceView: ADRB2 Ensembl:ENSG00000169252 euGenes: HUgn154
    ECgene: ADRB2 Kegg: 154 H-InvDB: ADRB2

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for ADRB2 Pharmacogenomics, SNPs, Pathways
    GeneReviewshttp://www.ncbi.nlm.nih.gov/sites/GeneTests/lab/gene/ADRB2
    SeattleSNPshttp://pga.gs.washington.edu/data/adrb2/

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for ADRB2 gene:
    Search GeneIP for patents involving ADRB2

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0 and Sirion Biotech, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Sirion Biotech, Cell lines from GenScript, and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences, In Situ Hybridization Assays from
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    About This Section

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