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Aliases for ADRB2 Gene

Aliases for ADRB2 Gene

  • Adrenoceptor Beta 2, Surface 2 3
  • Adrenergic, Beta-2-, Receptor, Surface 2 3
  • Beta-2 Adrenoreceptor 3 4
  • Beta-2 Adrenoceptor 3 4
  • ADRB2R 3 4
  • B2AR 3 4
  • Adrenoceptor Beta 2 Surface 3
  • Beta-2 Adrenergic Receptor 3
  • Catecholamine Receptor 3
  • BETA2AR 3
  • ADRBR 3
  • BAR 3

External Ids for ADRB2 Gene

Previous HGNC Symbols for ADRB2 Gene

  • ADRB2R

Previous GeneCards Identifiers for ADRB2 Gene

  • GC05P148250
  • GC05M148800
  • GC05P148187
  • GC05P148235
  • GC05P148236
  • GC05P148186
  • GC05P143352

Summaries for ADRB2 Gene

Entrez Gene Summary for ADRB2 Gene

  • This gene encodes beta-2-adrenergic receptor which is a member of the G protein-coupled receptor superfamily. This receptor is directly associated with one of its ultimate effectors, the class C L-type calcium channel Ca(V)1.2. This receptor-channel complex also contains a G protein, an adenylyl cyclase, cAMP-dependent kinase, and the counterbalancing phosphatase, PP2A. The assembly of the signaling complex provides a mechanism that ensures specific and rapid signaling by this G protein-coupled receptor. This gene is intronless. Different polymorphic forms, point mutations, and/or downregulation of this gene are associated with nocturnal asthma, obesity and type 2 diabetes. [provided by RefSeq, Jul 2008]

GeneCards Summary for ADRB2 Gene

ADRB2 (Adrenoceptor Beta 2, Surface) is a Protein Coding gene. Diseases associated with ADRB2 include status asthmaticus and asthma. Among its related pathways are Signaling by GPCR and Activation of cAMP-Dependent PKA. GO annotations related to this gene include protein homodimerization activity and adenylate cyclase binding. An important paralog of this gene is TAAR9.

UniProtKB/Swiss-Prot for ADRB2 Gene

  • Beta-adrenergic receptors mediate the catecholamine-induced activation of adenylate cyclase through the action of G proteins. The beta-2-adrenergic receptor binds epinephrine with an approximately 30-fold greater affinity than it does norepinephrine

Tocris Summary for ADRB2 Gene

  • The adrenergic beta2 receptor (beta2-adrenoceptor) is a member of the adrenergic receptor group of G-protein-coupled receptors that also includes alpha1A, alpha1B, alpha1D, alpha2A, alpha2B, alpha2C, beta1 and beta3. They are located primarily in the CNS, heart, kidney and muscle where they are involved in smooth muscle relaxation (e.g. bronchodilation). The human adrenergic beta2 receptor gene has been localized to chromosome 5 (5q31-q32).

Gene Wiki entry for ADRB2 Gene

PharmGKB "VIP" Summary for ADRB2 Gene

No data available for fRNAdb sequence ontologies and piRNA Summary for ADRB2 Gene

Genomics for ADRB2 Gene

Regulatory Elements for ADRB2 Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for ADRB2 Gene

Start:
148,825,245 bp from pter
End:
148,828,687 bp from pter
Size:
3,443 bases
Orientation:
Plus strand

Genomic View for ADRB2 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for ADRB2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ADRB2 Gene

Proteins for ADRB2 Gene

  • Protein details for ADRB2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P07550-ADRB2_HUMAN
    Recommended name:
    Beta-2 adrenergic receptor
    Protein Accession:
    P07550
    Secondary Accessions:
    • B0LPE4
    • B2R7X2
    • O14823
    • O14824
    • O14825
    • O14826
    • Q4JG18
    • Q53GA6
    • Q6GMT4
    • Q6P4D8
    • Q8NEQ9
    • Q96EC3
    • Q9UCZ0
    • Q9UCZ1
    • Q9UCZ2
    • Q9UCZ3
    • Q9UH95
    • Q9UHA1
    • Q9UMZ5

    Protein attributes for ADRB2 Gene

    Size:
    413 amino acids
    Molecular mass:
    46459 Da
    Quaternary structure:
    • Binds SLC9A3R1 and GPRASP1. Interacts with ARRB1 and ARRB2. Interacts with SRC, USP20 and USP33. Interacts with VHL; the interaction, which is increased on hydroxylation of ADRB2, ubiquitinates ADRB2 leading to its degradation. Interacts with EGLN3; the interaction hydroxylates ADRB2 facilitating VHL-E3 ligase-mediated ubiquitination. Interacts (via PDZ-binding motif) with SNX27 (via PDZ domain); the interaction is required when endocytosed to prevent degradation in lysosomes and promote recycling to the plasma membrane. Interacts with CNIH4 (PubMed:24405750).
    SequenceCaution:
    • Sequence=BAD96745.1; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for ADRB2 Gene

neXtProt entry for ADRB2 Gene

Proteomics data for ADRB2 Gene at MOPED

Post-translational modifications for ADRB2 Gene

  • Hydroxylation by EGLN3 occurs only under normoxia and increases the interaction with VHL and the subsequent ubiquitination and degradation of ADRB2.
  • Palmitoylated; may reduce accessibility of Ser-345 and Ser-346 by anchoring Cys-341 to the plasma membrane. Agonist stimulation promotes depalmitoylation and further allows Ser-345 and Ser-346 phosphorylation.
  • Phosphorylated by PKA and BARK upon agonist stimulation, which mediates homologous desensitization of the receptor. PKA-mediated phosphorylation seems to facilitate phosphorylation by BARK
  • Phosphorylation of Tyr-141 is induced by insulin and leads to supersensitization of the receptor.
  • Polyubiquitinated. Agonist-induced ubiquitination leads to sort internalized receptors to the lysosomes for degradation. Deubiquitination by USP20 and USP33, leads to ADRB2 recycling and resensitization after prolonged agonist stimulation. USP20 and USP33 are constitutively associated and are dissociated immediately after agonist stimulation. Ubiquitination by the VHL-E3 ligase complex is oxygen-dependent.
  • Glycosylation at Asn6 and Asn15
  • Modification sites at PhosphoSitePlus

Other Protein References for ADRB2 Gene

ENSEMBL proteins:
Reactome Protein details:
REFSEQ proteins:

Antibody Products

  • Cell Signaling Technology (CST) Antibodies for ADRB2 (ADRB2)

No data available for DME Specific Peptides for ADRB2 Gene

Domains for ADRB2 Gene

Gene Families for ADRB2 Gene

HGNC:
  • ADRB :GPCR / Class A : Adrenoceptors : beta
IUPHAR :

Suggested Antigen Peptide Sequences for ADRB2 Gene

Graphical View of Domain Structure for InterPro Entry

P07550

UniProtKB/Swiss-Prot:

ADRB2_HUMAN :
  • P07550
Family:
  • Belongs to the G-protein coupled receptor 1 family. Adrenergic receptor subfamily. ADRB2 sub-subfamily.
genes like me logo Genes that share domains with ADRB2: view

Function for ADRB2 Gene

Molecular function for ADRB2 Gene

GENATLAS Biochemistry: adrenergic,beta-2-,receptor,G protein coupled receptor superfamily,activating adenylate cyclase,major lipolytic receptor in human fat cell altered in obesity,also associated to susceptibility to hypertension (polymorphism,R16G)
UniProtKB/Swiss-Prot Function: Beta-adrenergic receptors mediate the catecholamine-induced activation of adenylate cyclase through the action of G proteins. The beta-2-adrenergic receptor binds epinephrine with an approximately 30-fold greater affinity than it does norepinephrine

Gene Ontology (GO) - Molecular Function for ADRB2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004930 G-protein coupled receptor activity --
GO:0004941 beta2-adrenergic receptor activity IDA 15123695
GO:0005515 protein binding IPI 15123695
GO:0008179 adenylate cyclase binding IEA --
GO:0015459 potassium channel regulator activity IDA 12297500
genes like me logo Genes that share ontologies with ADRB2: view
genes like me logo Genes that share phenotypes with ADRB2: view

Animal Models for ADRB2 Gene

MGI Knock Outs for ADRB2:

Animal Model Products

CRISPR Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for ADRB2

Clone Products

  • Addgene plasmids for ADRB2
  • R&D Systems cDNA Clones for ADRB2 (beta-2 Adrenergic R/ADRB2)

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , miRNA , Transcription Factor Targeting and HOMER Transcription for ADRB2 Gene

Localization for ADRB2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ADRB2 Gene

Cell membrane; Multi-pass membrane protein. Note=Colocalizes with VHL at the cell membrane.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for ADRB2 Gene COMPARTMENTS Subcellular localization image for ADRB2 gene
Compartment Confidence
plasma membrane 5
endosome 4
lysosome 4
vacuole 4
extracellular 2
nucleus 2
cytoskeleton 1
cytosol 1
endoplasmic reticulum 1

Gene Ontology (GO) - Cellular Components for ADRB2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IEA --
GO:0005764 lysosome TAS 9507004
GO:0005768 endosome TAS 10734107
GO:0005886 plasma membrane TAS --
GO:0005887 integral component of plasma membrane IDA 12297500
genes like me logo Genes that share ontologies with ADRB2: view

Pathways for ADRB2 Gene

genes like me logo Genes that share pathways with ADRB2: view

PCR Array Products

Gene Ontology (GO) - Biological Process for ADRB2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001993 regulation of systemic arterial blood pressure by norepinephrine-epinephrine --
GO:0002024 diet induced thermogenesis IEA --
GO:0002025 vasodilation by norepinephrine-epinephrine involved in regulation of systemic arterial blood pressure IEA --
GO:0002028 regulation of sodium ion transport IEA --
GO:0002032 desensitization of G-protein coupled receptor protein signaling pathway by arrestin IDA 15123695
genes like me logo Genes that share ontologies with ADRB2: view

Compounds for ADRB2 Gene

(5) Tocris Compounds for ADRB2 Gene

Compound Action Cas Number
ICI 118,551 hydrochloride Very selective beta2 antagonist [72795-01-8]
Formoterol hemifumarate Potent and selective beta2 agonist [43229-80-7]
Salbutamol hemisulfate beta agonist (beta2 > beta1) [51022-70-9]
Salmeterol xinafoate Long-acting beta2 agonist; bronchodilator [94749-08-3]
Zinterol hydrochloride Selective beta2 agonist [37000-20-7]

(5) HMDB Compounds for ADRB2 Gene

Compound Synonyms Cas Number PubMed IDs
Epinephrine
  • (-)-(R)-Epinephrine
51-43-4
Norepinephrine
  • (-)-(R)-Norepinephrine
51-41-2
Propranolol
  • Dociton
525-66-6
Pseudoephedrine
  • (+)-(1S,2S)-Pseudoephedrine
90-82-4
Salbutamol
  • (l)-albuterol
18559-94-9

(48) Drugbank Compounds for ADRB2 Gene

Compound Synonyms Cas Number Type Actions PubMed IDs
(2S)-1-(9H-Carbazol-4-yloxy)-3-(isopropylamino)propan-2-ol
target
Acebutolol
  • Acebutolol HCL
37517-30-9 target partial agonist
Alprenolol
  • Alfeprol [Russian]
13655-52-2 target antagonist
Arbutamine
128470-16-6 target agonist
Arformoterol
67346-49-0 target agonist

(30) IUPHAR Ligand for ADRB2 Gene

Ligand Type Action Affinity Pubmed IDs
[125I]ICYP Antagonist Antagonist 11.1
formoterol Agonist Agonist 10.08
carvedilol Antagonist Antagonist 9.9
timolol Antagonist Antagonist 9.7
ICI 118551 Antagonist Inverse agonist 9.5
zinterol Agonist Agonist 9.48
CGP 12177 Antagonist Antagonist 9.4
SR59230A Antagonist Antagonist 9.3
bupranolol Antagonist Antagonist 9.1
alprenolol Antagonist Antagonist 9
salmeterol Agonist Full agonist 8.8
nadolol Antagonist Antagonist 8.6
procaterol Agonist Agonist 8.43
NIP Antagonist Antagonist 7.5
betaxolol Antagonist Antagonist 7.2
fenoterol Agonist Full agonist 6.9
isoprenaline Agonist Full agonist 6.4
metoprolol Antagonist Antagonist 6.3
cicloprolol Antagonist Antagonist 6.2
dobutamine Agonist Partial agonist 6.2
(-)-adrenaline Agonist Full agonist 6.2
salbutamol Agonist Partial agonist 6.1
atenolol Antagonist Antagonist 6
NIHP Antagonist Antagonist 6
Zn2+ Channel blocker None 6
terbutaline Agonist Partial agonist 5.6
ephedrine Agonist Partial agonist 5.6
LK 204-545 Antagonist Antagonist 5.2
noradrenaline Agonist Full agonist 4.3
propranolol Inhibitor Inhibition

(116) Novoseek inferred chemical compound relationships for ADRB2 Gene

Compound -log(P) Hits PubMed IDs
isoproterenol 84.9 88
zinterol 77.1 6
salbutamol 76.8 43
icyp 75 2
terbutaline 74 26

(9) PharmGKB related drug/compound annotations for ADRB2 Gene

genes like me logo Genes that share compounds with ADRB2: view

Transcripts for ADRB2 Gene

mRNA/cDNA for ADRB2 Gene

(8) Additional mRNA sequences :
(50) Selected AceView cDNA sequences:
(1) REFSEQ mRNAs :
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for ADRB2 Gene

Adrenoceptor beta 2, surface:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for ADRB2

Clone Products

  • Addgene plasmids for ADRB2
  • R&D Systems cDNA Clones for ADRB2 (beta-2 Adrenergic R/ADRB2)

Primer Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for ADRB2 Gene

No ASD Table

Relevant External Links for ADRB2 Gene

GeneLoc Exon Structure for
ADRB2
ECgene alternative splicing isoforms for
ADRB2

Expression for ADRB2 Gene

mRNA expression in normal human tissues for ADRB2 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for ADRB2 Gene

This gene is overexpressed in Skin - Not Sun Exposed (Suprapubic) (5.4) and Skin - Sun Exposed (Lower leg) (4.8).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for ADRB2 Gene

SOURCE GeneReport for Unigene cluster for ADRB2 Gene Hs.2551

genes like me logo Genes that share expressions with ADRB2: view

In Situ Assay Products

No data available for mRNA Expression by UniProt/SwissProt for ADRB2 Gene

Orthologs for ADRB2 Gene

This gene was present in the common ancestor of animals.

Orthologs for ADRB2 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia ADRB2 35
  • 99.6 (n)
  • 99.03 (a)
ADRB2 36
  • 100 (a)
OneToOne
cow
(Bos Taurus)
Mammalia ADRB2 35
  • 89.99 (n)
  • 89.1 (a)
ADRB2 36
  • 88 (a)
OneToOne
dog
(Canis familiaris)
Mammalia ADRB2 35
  • 90 (n)
  • 90.24 (a)
ADRB2 36
  • 81 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Adrb2 35
  • 85.71 (n)
  • 87.65 (a)
Adrb2 16
Adrb2 36
  • 87 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia ADRB2 36
  • 78 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Adrb2 35
  • 87.09 (n)
  • 88.14 (a)
chicken
(Gallus gallus)
Aves ADRB2 35
  • 78.16 (n)
  • 80 (a)
lizard
(Anolis carolinensis)
Reptilia ADRB2 36
  • 65 (a)
OneToOne
African clawed frog
(Xenopus laevis)
Amphibia MGC68724 35
tropical clawed frog
(Silurana tropicalis)
Amphibia adrb2 35
  • 67.43 (n)
  • 66.5 (a)
zebrafish
(Danio rerio)
Actinopterygii adrb2a 36
  • 54 (a)
OneToMany
adrb2b 35
  • 62.98 (n)
  • 60.22 (a)
adrb2b 36
  • 52 (a)
OneToMany
African malaria mosquito
(Anopheles gambiae)
Insecta GPRNNA2 35
  • 51.13 (n)
  • 42.12 (a)
fruit fly
(Drosophila melanogaster)
Insecta oa2 36
  • 25 (a)
ManyToMany
Octbeta2R 35
  • 50.3 (n)
  • 41.42 (a)
Octbeta2R 36
  • 25 (a)
ManyToMany
DopR2 37
  • 45 (a)
CG6989 37
  • 40 (a)
CG6919 37
  • 39 (a)
DopR 37
  • 33 (a)
worm
(Caenorhabditis elegans)
Secernentea M03F4.3 37
  • 34 (a)
Species with no ortholog for ADRB2:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for ADRB2 Gene

ENSEMBL:
Gene Tree for ADRB2 (if available)
TreeFam:
Gene Tree for ADRB2 (if available)

Paralogs for ADRB2 Gene

Paralogs for ADRB2 Gene

genes like me logo Genes that share paralogs with ADRB2: view

Variants for ADRB2 Gene

Polymorphic Variants from UniProtKB/Swiss-Prot for ADRB2 Gene

P07550-ADRB2_HUMAN
The Gly-16 allele is overrepresented in individuals affected by nocturnal asthma as compared to controls, and appears to be an important genetic factor in the expression of this asthmatic phenotype

Sequence variations from dbSNP and Humsavar for ADRB2 Gene

SNP ID Clin Chr 05 pos Sequence Context AA Info Type MAF
rs1042711 -- 148,826,785(+) CCGCC(C/T)GCTGA utr-variant-5-prime
rs1042713 other, - 148,826,877(+) CCAAT(A/G)GAAGC reference, missense
rs1042714 other, - 148,826,910(+) CGCAG(C/G)AAAGG reference, missense
rs1042717 -- 148,827,083(+) GGCCT(A/G)GCAGT synonymous-codon, reference
rs1042718 -- 148,827,354(+) GGTAC(A/C)GGGCC synonymous-codon, reference

Relevant External Links for ADRB2 Gene

HapMap Linkage Disequilibrium report
ADRB2
Human Gene Mutation Database (HGMD)
ADRB2

No data available for Structural Variations from Database of Genomic Variants (DGV) for ADRB2 Gene

Disorders for ADRB2 Gene

(2) OMIM Diseases for ADRB2 Gene (109690)

(4) University of Copenhagen DISEASES for ADRB2 Gene

(93) Novoseek inferred disease relationships for ADRB2 Gene

Disease -log(P) Hits PubMed IDs
asthma 68.9 178
status asthmaticus 42.2 4
heart failure 39.4 22
obesity 39.2 54
essential hypertension 39 18

Relevant External Links for ADRB2

Genetic Association Database (GAD)
ADRB2
Human Genome Epidemiology (HuGE) Navigator
ADRB2
genes like me logo Genes that share disorders with ADRB2: view

No data available for UniProtKB/Swiss-Prot for ADRB2 Gene

Publications for ADRB2 Gene

  1. Genetic polymorphisms of the beta 2-adrenergic receptor in nocturnal and nonnocturnal asthma. Evidence that Gly16 correlates with the nocturnal phenotype. (PMID: 7706471) Turki J. … Liggett S.B. (J. Clin. Invest. 1995) 3 4 23 48
  2. Mutations in the gene encoding for the beta 2-adrenergic receptor in normal and asthmatic subjects. (PMID: 8383511) Reihsaus E. … Liggett S.B. (Am. J. Respir. Cell Mol. Biol. 1993) 3 4 23 48
  3. Pharmacogenetic differences in response to albuterol between Puerto Ricans and Mexicans with asthma. (PMID: 15557128) Choudhry S. … Burchard E.G. (Am. J. Respir. Crit. Care Med. 2005) 3 23 25 48
  4. Beta2-adrenergic receptor allele frequencies in the Quechua, a high altitude native population. (PMID: 11246467) Rupert J.L. … Hochachka P.W. (Ann. Hum. Genet. 2000) 3 4 23
  5. The E27 beta2-adrenergic receptor polymorphism reduces the risk of myocardial infarction in dyslipidemic young males. (PMID: 11246538) Sala G. … De Blasi A. (Thromb. Haemost. 2001) 3 23 48

Products for ADRB2 Gene

  • Addgene plasmids for ADRB2

Sources for ADRB2 Gene

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