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Aliases for ADRB2 Gene

Aliases for ADRB2 Gene

  • Adrenoceptor Beta 2 2 3 5
  • Adrenergic, Beta-2-, Receptor, Surface 2 3
  • Adrenoceptor Beta 2, Surface 2 3
  • Beta-2 Adrenoreceptor 3 4
  • Beta-2 Adrenoceptor 3 4
  • ADRB2R 3 4
  • B2AR 3 4
  • Adrenoceptor Beta 2 Surface 3
  • Catecholamine Receptor 3
  • BETA2AR 3
  • ADRBR 3
  • BAR 3

External Ids for ADRB2 Gene

Previous HGNC Symbols for ADRB2 Gene

  • ADRB2R

Previous GeneCards Identifiers for ADRB2 Gene

  • GC05P148250
  • GC05M148800
  • GC05P148187
  • GC05P148235
  • GC05P148236
  • GC05P148186
  • GC05P143352

Summaries for ADRB2 Gene

Entrez Gene Summary for ADRB2 Gene

  • This gene encodes beta-2-adrenergic receptor which is a member of the G protein-coupled receptor superfamily. This receptor is directly associated with one of its ultimate effectors, the class C L-type calcium channel Ca(V)1.2. This receptor-channel complex also contains a G protein, an adenylyl cyclase, cAMP-dependent kinase, and the counterbalancing phosphatase, PP2A. The assembly of the signaling complex provides a mechanism that ensures specific and rapid signaling by this G protein-coupled receptor. This gene is intronless. Different polymorphic forms, point mutations, and/or downregulation of this gene are associated with nocturnal asthma, obesity and type 2 diabetes. [provided by RefSeq, Jul 2008]

GeneCards Summary for ADRB2 Gene

ADRB2 (Adrenoceptor Beta 2) is a Protein Coding gene. Diseases associated with ADRB2 include obesity and asthma. Among its related pathways are Signaling by GPCR and cAMP signaling pathway. GO annotations related to this gene include G-protein coupled receptor activity and enzyme binding. An important paralog of this gene is TAAR9.

UniProtKB/Swiss-Prot for ADRB2 Gene

  • Beta-adrenergic receptors mediate the catecholamine-induced activation of adenylate cyclase through the action of G proteins. The beta-2-adrenergic receptor binds epinephrine with an approximately 30-fold greater affinity than it does norepinephrine.

Tocris Summary for ADRB2 Gene

  • The adrenergic beta2 receptor (beta2-adrenoceptor) is a member of the adrenergic receptor group of G-protein-coupled receptors that also includes alpha1A, alpha1B, alpha1D, alpha2A, alpha2B, alpha2C, beta1 and beta3. They are located primarily in the CNS, heart, kidney and muscle.

Gene Wiki entry for ADRB2 Gene

PharmGKB "VIP" Summary for ADRB2 Gene

No data available for fRNAdb sequence ontologies and piRNA Summary for ADRB2 Gene

Genomics for ADRB2 Gene

Regulatory Elements for ADRB2 Gene

Genomic Location for ADRB2 Gene

Chromosome:
5
Start:
148,825,245 bp from pter
End:
148,828,687 bp from pter
Size:
3,443 bases
Orientation:
Plus strand

Genomic View for ADRB2 Gene

Genes around ADRB2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ADRB2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ADRB2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ADRB2 Gene

Proteins for ADRB2 Gene

  • Protein details for ADRB2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P07550-ADRB2_HUMAN
    Recommended name:
    Beta-2 adrenergic receptor
    Protein Accession:
    P07550
    Secondary Accessions:
    • B0LPE4
    • B2R7X2
    • O14823
    • O14824
    • O14825
    • O14826
    • Q4JG18
    • Q53GA6
    • Q6GMT4
    • Q6P4D8
    • Q8NEQ9
    • Q96EC3
    • Q9UCZ0
    • Q9UCZ1
    • Q9UCZ2
    • Q9UCZ3
    • Q9UH95
    • Q9UHA1
    • Q9UMZ5

    Protein attributes for ADRB2 Gene

    Size:
    413 amino acids
    Molecular mass:
    46459 Da
    Quaternary structure:
    • Binds SLC9A3R1 and GPRASP1. Interacts with ARRB1 and ARRB2. Interacts with SRC, USP20 and USP33. Interacts with VHL; the interaction, which is increased on hydroxylation of ADRB2, ubiquitinates ADRB2 leading to its degradation. Interacts with EGLN3; the interaction hydroxylates ADRB2 facilitating VHL-E3 ligase-mediated ubiquitination. Interacts (via PDZ-binding motif) with SNX27 (via PDZ domain); the interaction is required when endocytosed to prevent degradation in lysosomes and promote recycling to the plasma membrane. Interacts with CNIH4 (PubMed:24405750). Interacts with ARRDC3 (PubMed:20559325, PubMed:25220262).
    SequenceCaution:
    • Sequence=BAD96745.1; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for ADRB2 Gene

neXtProt entry for ADRB2 Gene

Proteomics data for ADRB2 Gene at MOPED

Post-translational modifications for ADRB2 Gene

  • Hydroxylation by EGLN3 occurs only under normoxia and increases the interaction with VHL and the subsequent ubiquitination and degradation of ADRB2.
  • Palmitoylated; may reduce accessibility of Ser-345 and Ser-346 by anchoring Cys-341 to the plasma membrane. Agonist stimulation promotes depalmitoylation and further allows Ser-345 and Ser-346 phosphorylation.
  • Phosphorylated by PKA and BARK upon agonist stimulation, which mediates homologous desensitization of the receptor. PKA-mediated phosphorylation seems to facilitate phosphorylation by BARK.
  • Phosphorylation of Tyr-141 is induced by insulin and leads to supersensitization of the receptor.
  • Polyubiquitinated. Agonist-induced ubiquitination leads to sort internalized receptors to the lysosomes for degradation (PubMed:19424180, PubMed:20559325). Deubiquitination by USP20 and USP33, leads to ADRB2 recycling and resensitization after prolonged agonist stimulation. USP20 and USP33 are constitutively associated and are dissociated immediately after agonist stimulation. Ubiquitination by the VHL-E3 ligase complex is oxygen-dependent.
  • Glycosylation at Asn 6 and Asn 15
  • Modification sites at PhosphoSitePlus

Other Protein References for ADRB2 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for ADRB2 Gene

Domains & Families for ADRB2 Gene

Gene Families for ADRB2 Gene

Suggested Antigen Peptide Sequences for ADRB2 Gene

Graphical View of Domain Structure for InterPro Entry

P07550

UniProtKB/Swiss-Prot:

ADRB2_HUMAN :
  • Belongs to the G-protein coupled receptor 1 family. Adrenergic receptor subfamily. ADRB2 sub-subfamily.
Family:
  • Belongs to the G-protein coupled receptor 1 family. Adrenergic receptor subfamily. ADRB2 sub-subfamily.
genes like me logo Genes that share domains with ADRB2: view

Function for ADRB2 Gene

Molecular function for ADRB2 Gene

GENATLAS Biochemistry:
adrenergic,beta-2-,receptor,G protein coupled receptor superfamily,activating adenylate cyclase,major lipolytic receptor in human fat cell altered in obesity,also associated to susceptibility to hypertension (polymorphism,R16G)
UniProtKB/Swiss-Prot Function:
Beta-adrenergic receptors mediate the catecholamine-induced activation of adenylate cyclase through the action of G proteins. The beta-2-adrenergic receptor binds epinephrine with an approximately 30-fold greater affinity than it does norepinephrine.

Gene Ontology (GO) - Molecular Function for ADRB2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IEA,IPI 9560162
GO:0008179 adenylate cyclase binding IEA --
GO:0019899 enzyme binding IEA --
genes like me logo Genes that share ontologies with ADRB2: view
genes like me logo Genes that share phenotypes with ADRB2: view

Animal Models for ADRB2 Gene

MGI Knock Outs for ADRB2:

Animal Model Products

miRNA for ADRB2 Gene

miRTarBase miRNAs that target ADRB2

Inhibitory RNA Products

Clone Products

  • Addgene plasmids for ADRB2
  • R&D Systems cDNA Clones for ADRB2 (beta-2 Adrenergic R/ADRB2)

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for ADRB2 Gene

Localization for ADRB2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ADRB2 Gene

Cell membrane; Multi-pass membrane protein. Early endosome. Note=Colocalizes with VHL at the cell membrane (PubMed:19584355). Activated receptors are internalized into endosomes prior to their degradation in lysosomes (PubMed:20559325). {ECO:0000269 PubMed:19584355, ECO:0000269 PubMed:20559325}.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for ADRB2 Gene COMPARTMENTS Subcellular localization image for ADRB2 gene
Compartment Confidence
endosome 5
lysosome 5
plasma membrane 5
vacuole 5
extracellular 3
nucleus 3
cytoskeleton 2
endoplasmic reticulum 2
cytosol 1
mitochondrion 1

Gene Ontology (GO) - Cellular Components for ADRB2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm IEA --
GO:0005887 integral component of plasma membrane IDA 12297500
GO:0016020 membrane IEA --
GO:0030425 dendrite IEA --
GO:0043197 dendritic spine IEA --
genes like me logo Genes that share ontologies with ADRB2: view

Pathways & Interactions for ADRB2 Gene

genes like me logo Genes that share pathways with ADRB2: view

SIGNOR curated interactions for ADRB2 Gene

Activates:
Is inactivated by:

Gene Ontology (GO) - Biological Process for ADRB2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001889 liver development IEA --
GO:0002025 vasodilation by norepinephrine-epinephrine involved in regulation of systemic arterial blood pressure IEA,IBA --
GO:0002032 desensitization of G-protein coupled receptor protein signaling pathway by arrestin IDA 15123695
GO:0002086 diaphragm contraction IEA --
GO:0003059 positive regulation of the force of heart contraction by epinephrine IEA --
genes like me logo Genes that share ontologies with ADRB2: view

Drugs & Compounds for ADRB2 Gene

(158) Drugs for ADRB2 Gene - From: Novoseek, PharmGKB, IUPHAR, DGIdb, DrugBank, HMDB, Tocris, and ApexBio

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Isoproterenol Approved Pharma Full agonist, Agonist, agonist, Target 19
Propranolol Approved, Investigational Pharma Antagonist, antagonist, Target 202
Salbutamol Approved Pharma Partial agonist, Agonist, agonist, Target 0
salmeterol Approved Pharma Full agonist, Agonist, agonist, Target 0
Terbutaline Approved Pharma Partial agonist, Agonist, agonist, Target 39

(46) Additional Compounds for ADRB2 Gene - From: Novoseek, Tocris, and HMDB

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
8-Hydroxycarvedilol
ICI 118,551 hydrochloride
72795-01-8
Procaterol hydrochloride
62929-91-3
Zinterol hydrochloride
37000-20-7
genes like me logo Genes that share compounds with ADRB2: view

Drug Products

Transcripts for ADRB2 Gene

mRNA/cDNA for ADRB2 Gene

(1) REFSEQ mRNAs :
(8) Additional mRNA sequences :
(50) Selected AceView cDNA sequences:
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for ADRB2 Gene

Adrenoceptor beta 2, surface:
Representative Sequences:

Inhibitory RNA Products

Clone Products

  • Addgene plasmids for ADRB2
  • R&D Systems cDNA Clones for ADRB2 (beta-2 Adrenergic R/ADRB2)

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for ADRB2 Gene

No ASD Table

Relevant External Links for ADRB2 Gene

GeneLoc Exon Structure for
ADRB2
ECgene alternative splicing isoforms for
ADRB2

Expression for ADRB2 Gene

mRNA expression in normal human tissues for ADRB2 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for ADRB2 Gene

This gene is overexpressed in Skin - Not Sun Exposed (Suprapubic) (x5.4) and Skin - Sun Exposed (Lower leg) (x4.8).

Protein differential expression in normal tissues from HIPED for ADRB2 Gene

This gene is overexpressed in Placenta (69.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for ADRB2 Gene



SOURCE GeneReport for Unigene cluster for ADRB2 Gene Hs.2551

genes like me logo Genes that share expression patterns with ADRB2: view

Protein tissue co-expression partners for ADRB2 Gene

Primer Products

In Situ Assay Products

No data available for mRNA Expression by UniProt/SwissProt for ADRB2 Gene

Orthologs for ADRB2 Gene

This gene was present in the common ancestor of animals.

Orthologs for ADRB2 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia ADRB2 35
  • 89.99 (n)
  • 89.1 (a)
ADRB2 36
  • 88 (a)
OneToOne
dog
(Canis familiaris)
Mammalia ADRB2 35
  • 90 (n)
  • 90.24 (a)
ADRB2 36
  • 81 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Adrb2 35
  • 85.71 (n)
  • 87.65 (a)
Adrb2 16
Adrb2 36
  • 87 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia ADRB2 35
  • 99.6 (n)
  • 99.03 (a)
ADRB2 36
  • 100 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Adrb2 35
  • 87.09 (n)
  • 88.14 (a)
oppossum
(Monodelphis domestica)
Mammalia ADRB2 36
  • 78 (a)
OneToOne
chicken
(Gallus gallus)
Aves ADRB2 35
  • 78.16 (n)
  • 80 (a)
lizard
(Anolis carolinensis)
Reptilia ADRB2 36
  • 65 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia adrb2 35
  • 67.43 (n)
  • 66.5 (a)
African clawed frog
(Xenopus laevis)
Amphibia MGC68724 35
zebrafish
(Danio rerio)
Actinopterygii adrb2b 35
  • 62.98 (n)
  • 60.22 (a)
adrb2a 36
  • 54 (a)
OneToMany
adrb2b 36
  • 52 (a)
OneToMany
fruit fly
(Drosophila melanogaster)
Insecta CG6919 37
  • 39 (a)
CG6989 37
  • 40 (a)
DopR 37
  • 33 (a)
DopR2 37
  • 45 (a)
Octbeta2R 35
  • 50.3 (n)
  • 41.42 (a)
oa2 36
  • 25 (a)
ManyToMany
Octbeta2R 36
  • 25 (a)
ManyToMany
African malaria mosquito
(Anopheles gambiae)
Insecta GPRNNA2 35
  • 51.13 (n)
  • 42.12 (a)
worm
(Caenorhabditis elegans)
Secernentea M03F4.3 37
  • 34 (a)
Species with no ortholog for ADRB2:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for ADRB2 Gene

ENSEMBL:
Gene Tree for ADRB2 (if available)
TreeFam:
Gene Tree for ADRB2 (if available)

Paralogs for ADRB2 Gene

Paralogs for ADRB2 Gene

genes like me logo Genes that share paralogs with ADRB2: view

Variants for ADRB2 Gene

Polymorphic Variants from UniProtKB/Swiss-Prot for ADRB2 Gene

P07550-ADRB2_HUMAN
The Gly-16 allele is overrepresented in individuals affected by nocturnal asthma as compared to controls, and appears to be an important genetic factor in the expression of this asthmatic phenotype.

Sequence variations from dbSNP and Humsavar for ADRB2 Gene

SNP ID Clin Chr 05 pos Sequence Context AA Info Type
rs1042713 - 148,826,877(+) CCAAT(A/G)GAAGC reference, missense
rs1042714 - 148,826,910(+) CGCAG(C/G/T)AAAGG reference, missense
VAR_003454 -
rs1800888 - 148,827,322(+) CCTTA(C/T)CTCCT reference, missense
VAR_009124 -

Variation tolerance for ADRB2 Gene

Residual Variation Intolerance Score: 29.6% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 9.34; 88.36% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for ADRB2 Gene

HapMap Linkage Disequilibrium report
ADRB2
Human Gene Mutation Database (HGMD)
ADRB2

No data available for Structural Variations from Database of Genomic Variants (DGV) for ADRB2 Gene

Disorders for ADRB2 Gene

MalaCards: The human disease database

(26) MalaCards diseases for ADRB2 Gene - From: OMIM, ClinVar, DISEASES, Novoseek, and GeneCards

Disorder Aliases PubMed IDs
obesity
  • obesity, association with
asthma
  • asthma, protection against
status asthmaticus
  • asthma with status asthmaticus
congestive heart failure
  • cardiac failure congestive
ocular hypotension
  • hypotony of eye
- elite association - COSMIC cancer census association via MalaCards
Search ADRB2 in MalaCards View complete list of genes associated with diseases

Relevant External Links for ADRB2

Genetic Association Database (GAD)
ADRB2
Human Genome Epidemiology (HuGE) Navigator
ADRB2
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
ADRB2
genes like me logo Genes that share disorders with ADRB2: view

No data available for UniProtKB/Swiss-Prot and Genatlas for ADRB2 Gene

Publications for ADRB2 Gene

  1. Genetic polymorphisms of the beta 2-adrenergic receptor in nocturnal and nonnocturnal asthma. Evidence that Gly16 correlates with the nocturnal phenotype. (PMID: 7706471) Turki J. … Liggett S.B. (J. Clin. Invest. 1995) 3 4 48 67
  2. A chemical biology approach identifies a beta-2 adrenergic receptor agonist that causes human tumor regression by blocking the Raf-1/Mek-1/Erk1/2 pathway. (PMID: 17260025) Carie A.E. … Sebti S.M. (Oncogene 2007) 23 25 26
  3. Impaired antibody synthesis after spinal cord injury is level dependent and is due to sympathetic nervous system dysregulation. (PMID: 17597612) Lucin K.M. … Popovich P.G. (Exp. Neurol. 2007) 23 25 26
  4. Molecular dynamics of a biophysical model for beta2-adrenergic and G protein-coupled receptor activation. (PMID: 16574446) Rubenstein L.A. … Lanzara R.G. (J. Mol. Graph. Model. 2006) 23 25 26
  5. Pharmacogenetic differences in response to albuterol between Puerto Ricans and Mexicans with asthma. (PMID: 15557128) Choudhry S. … Burchard E.G. (Am. J. Respir. Crit. Care Med. 2005) 3 23 25

Products for ADRB2 Gene

Sources for ADRB2 Gene

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