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Category Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21

GIFtS
-

ADRB1 Gene

protein-coding GIFtS: 67
GCID: GC10P115793

adrenoceptor beta 1

(Previous names: adrenergic, beta-1-, receptor )
(Previous symbol: ADRB1R)

Explore 65 diseases affiliated with
ADRB1 via

MalaCards

our new
Human Malady Compendium

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc, ⁷Ensembl, ⁸DME, ⁹miRBase, and/or ¹⁰fRNAdb)
About This Section

Aliases
Adrenoceptor Beta 1¹ ²		B1AR² ³
ADRB1R¹ ² ³ ⁵		RHR² ⁵
Adrenergic, Beta-1-, Receptor¹ ²		BETA1AR²
Beta-1 Adrenoceptor² ³		Beta-1 Adrenergic Receptor²
Beta-1 Adrenoreceptor² ³

External Ids:	HGNC: 285¹	Entrez Gene: 153²	Ensembl: ENSG00000043591⁷	OMIM: 109630⁵	UniProtKB: P08588³

Export aliases for ADRB1 gene to outside databases

Previous GC identifers: GC10P114711 GC10P115037 GC10P115935 GC10P115468 GC10P109429

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for ADRB1:

The adrenergic receptors (subtypes alpha 1, alpha 2, beta 1, and beta 2) are a prototypic family of guanine nucleotide

binding regulatory protein-coupled receptors that mediate the physiological effects of the hormone epinephrine and the

neurotransmitter norepinephrine. Specific polymorphisms in this gene have been shown to affect the resting heart rate

and can be involved in heart failure. (provided by RefSeq, Jul 2008)

UniProtKB/Swiss-Prot: ADRB1_HUMAN, P08588

Function: Beta-adrenergic receptors mediate the catecholamine-induced activation of adenylate cyclase through the

action of G proteins. This receptor binds epinephrine and norepinephrine with approximately equal affinity

summary for ADRB1:

The adrenergic beta1 receptor (beta1-adrenoceptor) is a member of the adrenergic receptor group of

G-protein-coupled receptors that also includes alpha1A, alpha1B, alpha1D, alpha2A, alpha2B, alpha2C, beta2

and beta3. They are located primarily in the CNS, heart, coronary artery, kidney and muscle and are involved

in cardiac stimulation, coronary vasodilation and relaxation of the colon and esophagus. The human

adrenergic beta1 receptor gene has been localized to chromosome 10 (10q24-q26).

Gene Wiki entry for ADRB1 (Beta-1 adrenergic receptor)

PharmGKB "VIP" summary for ADRB1

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section

RefSeq DNA sequence:

NC_000010.10 NC_018921.1 NT_030059.13

Regulatory elements:

SABiosciences Regulatory transcription factor binding sites in the ADRB1 gene promoter:
HFH-3 c-Fos AP-1 C/EBPalpha CREB FOXI1 Pax-3 deltaCREB c-Jun ATF
Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: ADRB1 promoter sequence

Search SABiosciences Chromatin IP Primers for ADRB1

Epigenetics:

QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat ADRB1

Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 10q25.3 Ensembl cytogenetic band: 10q25.3 HGNC cytogenetic band: 10q25.3

ADRB1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
ADRB1 gene location

GeneLoc information about chromosome 10 GeneLoc Exon Structure

GeneLoc location for GC10P115793: view genomic region (about GC identifiers)

Start:	115,803,806 bp from pter	End:	115,806,667 bp from pter
Size:	2,862 bases	Orientation:	plus strand

(According to ¹UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to ²PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section

UniProtKB/Swiss-Prot: ADRB1_HUMAN, P08588 (See protein sequence)

Recommended Name: Beta-1 adrenergic receptor

Size: 477 amino acids; 51323 Da

Subunit: Interacts with GOPC, MAGI3 and DLG4

Subcellular location: Cell membrane; Multi-pass membrane protein. Note=Localized at the plasma membrane. Found in the

Golgi upon GOPC overexpression

Secondary accessions: B0LPE2 Q5T5Y4 Q9UKG7 Q9UKG8

Explore the universe of human proteins at neXtProt for ADRB1: NX_P08588

Post-translational modifications:

Homologous desensitization of the receptor is mediated by its phosphorylation by beta-adrenergic receptor kinase¹

View modification sites using PhosphoSitePlus²

View neXtProt modification sites for NX_P08588

ADRB1 Protein expression data from MOPED and PaxDb: About this image

REFSEQ proteins: NP_000675.1

ENSEMBL proteins:

ENSP00000358301

Reactome Protein details: P08588
Human Recombinant Protein Products:

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	Browse ProSpec Recombinant Proteins
	Browse Proteins at Uscn

Gene Ontology (GO): 5/6 cellular component terms (GO ID links to tree view) (see all 6): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005624	membrane fraction	--	--
GO:0005634	nucleus	IEA	--
GO:0005737	cytoplasm	IEA	--
GO:0005792	microsome	--	--
GO:0005886	plasma membrane	TAS	--

ADRB1 for ontologies About GeneDecksing

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	Browse ELISAs and CLIAs at Uscn

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

ADRB1 for domains About GeneDecksing

4 InterPro domains/families:

IPR017452 GPCR_Rhodpsn_7TM

IPR002233 Adrnrgc_rcpt

IPR000507 Adrgc_rcpt_B1

IPR000276 GPCR_Rhodpsn

Graphical View of Domain Structure for InterPro Entry P08588

ProtoNet protein and cluster: P08588

2 Blocks protein families:

IPB000507 Beta-1 adrenergic receptor signature

IPB002233 Adrenergic receptor signature

UniProtKB/Swiss-Prot: ADRB1_HUMAN, P08588

Domain: The PDZ domain-binding motif mediates competitive interactions with GOPC, MAGI3 and DLG4 and plays a role in

subcellular location of the receptor

Similarity: Belongs to the G-protein coupled receptor 1 family. Adrenergic receptor subfamily. ADRB1 sub-subfamily

(According to ¹UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or ²DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
About This Section

Function Summary:

UniProtKB/Swiss-Prot: ADRB1_HUMAN, P08588

Function: Beta-adrenergic receptors mediate the catecholamine-induced activation of adenylate cyclase through the

action of G proteins. This receptor binds epinephrine and norepinephrine with approximately equal affinity

Genatlas biochemistry entry for ADRB1:

adrenergic,beta-1-,receptor,G protein coupled receptor superfamily,mostly expressed in heart,activating adenylate

cyclase,lung,placenta,cerebral cortex,and in other organs mediating the action of catecholamines and sympathetic

nervous system,with no apparent association of the C1165G variant with idiopathic cardiomyopathy

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		QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat ADRB1
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		hsa-miR-520e hsa-miR-199a-3p hsa-miR-200a hsa-miR-374a hsa-miR-30d hsa-miR-342-3p hsa-miR-890 hsa-miR-1244

		SwitchGear 3'UTR luciferase reporter plasmid: ADRB1 3' UTR sequence

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In Situ Assay
Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ADRB1

Gene Ontology (GO): 5/10 molecular function terms (GO ID links to tree view) (see all 10): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0004939	beta-adrenergic receptor activity	TAS	8892658
GO:0004940	beta1-adrenergic receptor activity	IEA	--
GO:0005515	protein binding	IPI	16316992
GO:0008144	drug binding	IEA	--
GO:0030165	PDZ domain binding	IPI	11526121

ADRB1 for ontologies About GeneDecksing

1 GenomeRNAi human phenotype for ADRB1:

Increased gamma-H2AX phosphory

Animal Models:
Mouse knock-out Adrb1^tm1Bkk for ADRB1
9 MGI mutant phenotypes (inferred from 2 alleles) (MGI details for Adrb1):

adipose tissue	cardiovascular system	endocrine/exocrine gland	growth/size	homeostasis/metabolism
mortality/aging	muscle	no phenotypic analysis	skeleton

ADRB1 for phenotypes About GeneDecksing

(Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to ¹UniProtKB, ²MINT, ³I2D, and/or ⁴STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
About This Section

Unified GeneCards pathways - 5/23 super-pathways (see all 23) About this table

See pathways by source

Super-pathway

contained gene-specific pathways

Class A/1 (Rhodopsin-like receptors)

	Class A/1 (Rhodopsin-like receptors)	1.00			GPCRs, Class A Rhodopsin-like	0.41
	GPCR ligand binding	0.75			Neuroactive ligand-receptor interaction	0.38

Activation of cAMP-Dependent PKA

	Activation of cAMP-Dependent PKA	1.00			Activation of PKA through GPCR	0.71
	cAMP Pathway	0.77

Signaling by GPCR

	Signaling by GPCR	1.00			Signal Transduction	0.56
	GPCR downstream signaling	0.89

PKA activation in glucagon signalling

	Beta-2 adrenergic-dependent CFTR expression	0.74			Development_Beta-adrenergic receptors signaling via cAMP	0.29
	Development Beta-adrenergic receptors signaling via cAMP	0.29

Development_Ligand-independent activation of ESR1 and ESR2

Development_Ligand-independent activation of ESR1 and ESR2

1.00

Development Ligand-independent activation of ESR1 and ESR2

0.97

Pathway sources
See GeneCards unified pathways
Show all pathways

5/6 EMD Millipore Pathways for ADRB1 (see all 6)

	Development Beta-adrenergic receptors regulation of ERK
	Development Beta-adrenergic receptors signaling via cAMP
	G-protein signaling Rap2B regulation pathway
	Transcription CREB pathway
	G-protein signaling H-RAS regulation pathway

5/6 Downloadable PowerPoint Slides of QIAGEN Pathway Central Maps for ADRB1 (see all 6)

	Activation of PKA through GPCR
	cAMP Pathway
	Activation of cAMP-Dependent PKA
	Signaling in Gap Junctions
	Signaling Involved in Cardiac Hypertrophy

5/7 GeneGo (Thomson Reuters) Pathways for ADRB1 (see all 7)

	G-protein signaling H-RAS regulation pathway
	Development Ligand-independent activation of ESR1 and ESR2
	Development Beta-adrenergic receptors signaling via cAMP
	Beta-2 adrenergic-dependent CFTR expression
	G-protein signaling Rap2B regulation pathway

4 BioSystems Pathways for ADRB1

	Calcium Regulation in the Cardiac Cell
	Endothelin
	GPCRs, Class A Rhodopsin-like
	Monoamine GPCRs

5/8 Reactome Pathways for ADRB1 (see all 8)

	GPCR downstream signaling
	Signaling by GPCR
	GPCR ligand binding
	Adrenoceptors
	Class A/1 (Rhodopsin-like receptors)

2 PharmGKB Pathways for ADRB1

	Antiarrhythmic Pathway, Pharmacodynamics
	Sympathetic Nerve Pathway (Neuroeffector Junction)

5/6 Kegg Pathways (Kegg details for ADRB1) (see all 6):

	Calcium signaling pathway
	Neuroactive ligand-receptor interaction
	Endocytosis
	Gap junction
	Salivary secretion

ADRB1 for pathways About GeneDecksing

Interactions:

SABiosciences Gene Network Central^TM Interacting Genes and Proteins Network for ADRB1

STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

5/94 Interacting proteins for ADRB1 (P08588^{1, 2, 3} ENSP00000358301⁴) via UniProtKB, MINT, STRING, and/or I2D (see all 94)

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
MAGI2	Q86UL8¹^,²^,³, ENSP00000346151⁴	EBI-991009,EBI-311035 MINT-58358 MINT-58357 MINT-58359 MINT-58360 MINT-58361 I2D: score=3 STRING: ENSP00000346151
MAGI3	Q5TCQ9¹^,³, ENSP00000304604⁴	EBI-991009,EBI-991068 I2D: score=3 STRING: ENSP00000304604
DLG4	P78352³, ENSP00000293813⁴	I2D: score=3 STRING: ENSP00000293813
GOPC	Q9HD26³, ENSP00000357484⁴	I2D: score=3 STRING: ENSP00000357484
GPRASP1	Q5JY77³, ENSP00000355146⁴	I2D: score=3 STRING: ENSP00000355146

About this table

Gene Ontology (GO): 5/34 biological process terms (GO ID links to tree view) (see all 34): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0001996	positive regulation of heart rate by epinephrine-norepinephrine	IEA	--
GO:0001997	positive regulation of the force of heart contraction by epinephrine-norepinephrine	--	--
GO:0002024	diet induced thermogenesis	IEA	--
GO:0002025	vasodilation by norepinephrine-epinephrine involved in regulation of systemic arterial blood pressure	IEA	--
GO:0003061	positive regulation of the force of heart contraction by norepinephrine	IEA	--

ADRB1 for ontologies About GeneDecksing

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
About This Section

ADRB1 for compounds About GeneDecksing

Browse Small Molecules at EMD Millipore

Browse drugs & compounds from Enzo Life Sciences

Compounds for ADRB1 available from Tocris Bioscience About this table

Compound	Action	CAS #
Betaxolol hydrochloride	Selective beta1 antagonist	[63659-19-8]
(�)-Bisoprolol hemifumarate	beta1 antagonist	[104344-23-2]
(S)-Timolol maleate	beta1 antagonist	[26921-17-5]
Xamoterol hemifumarate	beta1 selective partial agonist	[73210-73-8]
CGP 20712 dihydrochloride	Highly potent and selective beta1 antagonist	[105737-62-0]

6 HMDB Compounds for ADRB1 About this table

Compound	Synonyms	CAS #	PubMed Ids
Atenolol	Aircrit (see all 104)	29122-68-7	--
Epinephrine	(-)-(R)-Epinephrine (see all 72)	51-43-4	--
Metoprolol	(+/-)-Metoprolol (see all 19)	37350-58-6	--
Norepinephrine	(-)-(R)-Norepinephrine (see all 32)	51-41-2	--
Propranolol	Dociton (see all 8)	525-66-6	--
Risperidone	Belivon (see all 7)	106266-06-2	--

10/42 DrugBank Compounds for ADRB1 (see all 42) About this table

Compound	Synonyms	CAS #	Type	Actions	PubMed Ids
Labetalol	Labetalol HCL (see all 4)	36894-69-6	target	antagonist	19879818 7286847 6151824 6355664 11752352 7684671 8104240 1687367
Alprenolol	Alfeprol [Russian] (see all 3)	13655-52-2	target	antagonist	10433496 2828119 12522078 11752352 7606348 7678677
Bisoprolol	Bisoprolol Fumarate (see all 3)	66722-44-9	target	antagonist	16325050 1280737 14757145 1676675 11752352 1691366
Bopindolol	--	69010-88-4	target	partial agonist	1687398 8884690 2907348 2148726 11752352 14608456
Esmolol	--	103598-03-4	target	antagonist	2894187 11752352 7957532 1975995 2568748 7612051
Levobunolol	Levobunolol HCl (see all 2)	47141-42-4	target	antagonist	7928182 10864881 2891463 2892662 1351412 11572462
Metoprolol	--	37350-58-6	target	antagonist	12844134 10913016 11448474 12679135 11752352 14534524
Nadolol	--	42200-33-9	target	antagonist	10433496 7981009 7912539 11752352 1354084 10606440
Oxprenolol	(+-)-oxprenolol (see all 9)	6452-71-7	target	antagonist	6124492 17139284 2871880 11752352 17016423 6202960
Pindolol	Betapindol (see all 2)	13523-86-9	target	partial agonist	1687398 8884690 2907348 2148726 11752352 14608456

10/53 Novoseek chemical compound relationships for ADRB1 gene (see all 53) About this table

Compound	-log (P-Val)	Hits	PubMed IDs for Articles with Shared Sentences (# sentences)
nebivolol	79.1	17	11789394 (1), 17977009 (1), 9010695 (1), 1681809 (1) (see all 15)
isoproterenol	76.5	42	11705454 (5), 7779864 (2), 14734046 (2), 17067575 (2) (see all 23)
xamoterol	73.9	9	17067575 (2), 1967560 (2), 1967561 (1), 1967562 (1) (see all 7)
metoprolol	73	9	11345390 (1), 18702968 (1), 17935678 (1), 11887345 (1) (see all 9)
zinterol	72.6	5	9915773 (2), 9884381 (1), 1311717 (1)
bucindolol	70.1	3	18403719 (1), 12847069 (1)
atenolol	70	13	18794726 (2), 8386603 (2), 15687340 (1), 12692005 (1) (see all 10)
betaxolol	68.7	6	16325708 (2), 17635183 (2), 10711687 (1), 10416766 (1)
bisoprolol	65.7	5	17217681 (3), 9832494 (1), 12860977 (1), 11887345 (1)
carvedilol	64.7	9	7908256 (4), 18787115 (1), 18702968 (1), 16475467 (1) (see all 6)

9 PharmGKB related drug/compound annotations for ADRB1 gene

Drug/compound	PharmGKB Annotation
Antihypertensives	CA
Beta Blocking Agents	CA
atenolol	CA
bisoprolol	CA
bucindolol	CA
carvedilol	CA
metoprolol	CA
muraglitazar	CA
verapamil	CA

About this table

Search CenterWatch for drugs/clinical trials and news about ADRB1

(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from EMD Millipore,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
About This Section

REFSEQ mRNAs for ADRB1 gene:

NM_000684.2

Unigene Cluster for ADRB1:

Adrenoceptor beta 1

Hs.99913 [show with all ESTs]

Unigene Representative Sequence: AF272890

1 Ensembl transcript including schematic representation, and UCSC links where relevant:

ENST00000369295(uc001lba.3)

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		QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat ADRB1
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		QIAGEN QuantiFast Probe-based Assays in human, mouse, rat ADRB1

Additional cDNA sequence:

AF272890.1 J03019.1 U29690.1

2 DOTS entries:

DT.92040573 DT.99969854

24/38 AceView cDNA sequences (see all 38):

AI003679 BM727728 AW138985 BX279952 BQ023488 AA702310 AW665324 BM681157

AA749352 BF055463 BU665017 AA383612 J03019 BC045633 BI836679 BX097351

AF272890 AI625747 NM_000684 BU633369 BM700625 BF108867 AA011176 C01127

GeneLoc Exon Structure

(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section

ADRB1 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: TGCAATAAAT

About this image

ADRB1 expression in embryonic tissues and stem cells

Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine About this table

1 LifeMap In Vivo Development Anatomical Compartment/Cell

Tissue

Anatomical Compartment

Cell

Category (developmental path)

Placenta

Chorioallantoic Placenta

Extraembryonic Angioblasts

Endothelium

Expression:

Positive

Negative

Selective marker

Experimental details:

Curated

Microarrays

In-situ hybridization

See ADRB1 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for ADRB1

SOURCE GeneReport for Unigene cluster: Hs.99913

SABiosciences Expression via Pathway-Focused PCR Arrays including ADRB1:

cAMP / Ca2+ Signaling PathwayFinder in human mouse rat

G-Protein-Coupled Receptor Signaling PathwayFinder in human mouse rat

G Protein Coupled Receptors 384HT in human mouse rat

Hypertension in human mouse rat

Obesity in human mouse rat

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(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD , ⁵MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or ⁶Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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This gene was present in the common ancestor of animals.

Orthologs for ADRB1 gene from 5/18 species (see all 18) About this table

Organism	Taxonomic classification	Gene	Description	Human Similarity	Orthology Type	Details
chicken (Gallus gallus)	Aves	ADRB1¹	adrenoceptor beta 1	68.55(n) 61.28(a)		430991 XM_428541.3 XP_428541.3
lizard (Anolis carolinensis)	Reptilia	ADRB1⁶	--	62(a)	1 ↔ 1	GL343204.1(291498-292796)
African clawed frog (Xenopus laevis)	Amphibia	Xl.14992²	X.laevis mRNA for beta-1-adrenergic receptor	77.58(n)		Y09213.1
zebrafish (Danio rerio)	Actinopterygii	adrb1⁶ adrb1⁶	adrenergic receptor, beta 1	62(a) 62(a)	1 ↔ many 1 ↔ many	12(32018119-32019291) 12(32170295-32171515)
fruit fly (Drosophila melanogaster)	Insecta	DopR2³ Octbeta2R¹	dopamine receptor signaling pathway dopamine receptor³ CG33976-PA¹	45(a) (best of 2)³ 49.84(n)¹ 38.32(a)¹		3 99B5³ 41549¹ NM_001038960.3¹ NP_001034049.1¹

ENSEMBL Gene Tree for ADRB1 (if available)
TreeFam Gene Tree for ADRB1 (if available)

(Paralogs according to ¹HomoloGene,
²Ensembl, and ³SIMAP, Pseudogenes according to ⁴Pseudogene.org Build 68)
About This Section

Paralogs for ADRB1 gene

TAAR6² HTR2A² HTR6² TAAR2² TAAR8² HRH2² HTR2B² DRD1²

HTR2C² TAAR1² ADRB2² HTR4² DRD5² ADRB3² TAAR5²

18/25 SIMAP similar genes for ADRB1 using alignment to 1 protein entry: ADRB1_HUMAN(see all similar genes):

ADRB2 hA2aR ADRB3 DRD5P1 HTR1D ADRA1B

ADRA1A DRD1 HTR1B HTR5A HRH3 ADRA1D

HRH2 HTR1E HTR1F HTR4 HTR4B DRD5

ADRB1 for paralogs About GeneDecksing

(SNPs/Variants according to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section

SNP ID	Valid	Clinical significance	Chr 10 pos	Sequence	#	AA Chg	Type	More	#	Allele freq	Pop	Total sample	More
Genomic Data					Transcription Related Data				Allele Frequencies
				--	--	--		--	--
rs1801253^1,2	C,F,A,H,	drug-response	115805056(+)	`TCCAGC/GGACTG`	2	R G	mis¹		34		NS NA EA MN CSA WA EU	22948
rs1801252^1,2	C,F,A,H,	pathogenic	115804036(+)	`GCGAAA/GGCCCC`	2	S G	mis¹ ese³		27		EA MN NS NA WA	21670
rs77066884^1,2	C,F,	--	115801954(+)	`TGTTCG/ATTACG`	1	--	us2k¹		1		WA	118
rs144178547^1,2		--	115801978(+)	`TTCCAA/GTGCTA`	1	--	us2k¹		0	--	--	--	--
rs184248459^1,2		--	115802078(+)	`TTTTTA/TAATTT`	1	--	us2k¹		0	--	--	--	--
rs17875440^1,2	C,F,	--	115802087(+)	`TTTTTT/AATTTT`	1	--	us2k¹ tfbs³		3		NS WA	206
rs146642556^1,2		--	115802095(+)	`TTTTTA/TTTTTA`	1	--	us2k¹		0	--	--	--	--
rs187737970^1,2		--	115802099(+)	`TTTTTA/TATTTC`	1	--	us2k¹		0	--	--	--	--
rs11593575^1,2	C,F,H,	--	115802198(+)	`TCACCC/GCCAGT`	1	--	us2k¹		2		NS NA	136
rs199700286^1,2	C	--	115802260(+)	`GCCAAA/CTNNNN`	1	--	us2k¹		0	--	--	--	--

HapMap Linkage Disequilibrium report for ADRB1 (115803806 - 115806667 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV) variations for ADRB1: --
Human Gene Mutation Database (HGMD): ADRB1

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(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
About This Section

ADRB1 for disorders           About GeneDecksing

OMIM gene information: 109630
OMIM disorders: 607276
20/65 diseases for ADRB1 (see all 65):    About MalaCards

congestive heart failure and beta-blocker response, modifier of (3) 19 resting heart rate congestive heart failure and beta-blocker response, modifier of congestive heart failure

open-angle glaucoma attention deficit hyperactivity disorder congenital aortic valve stenosis aortic valve stenosis

long qt syndrome myocardial infarction atrial fibrillation aortic coarctation

acute myocardial infarction orthostatic intolerance endomyocardial fibrosis coronary heart disease

ventricular tachycardia dilated cardiomyopathy myasthenia gravis sleep apnea

3 diseases from the University of Copenhagen DISEASES database for ADRB1:

Heart disease Hypertension Congenital aortic valve stenosis

10/34 Novoseek disease relationships for ADRB1 gene (see all 34) About this table

Disease	-log (P-Val)	Hits	PubMed IDs for Articles with Shared Sentences (# sentences)
heart failure	68.5	50	8522688 (5), 18947427 (4), 19945058 (3), 19010176 (3) (see all 31)
dilated cardiomyopathy	66.4	16	16153393 (3), 1283934 (2), 12791320 (2), 9846822 (1) (see all 11)
cardiomyopathy	52.4	8	16412044 (2), 17362986 (1), 9832494 (1), 19158054 (1) (see all 5)
neuroepithelioma	46.9	3	11705454 (1), 1671088 (1)
resting heart rate	42.3	4	11854867 (3), 16907703 (1)
heart failure congestive	42	8	12422153 (2), 1600963 (1), 12463096 (1), 18325466 (1) (see all 7)
essential hypertension	34.2	9	18298953 (3), 19743955 (2), 17635183 (1), 20235788 (1) (see all 6)
heart diseases	33.9	6	16878723 (1), 16816115 (1), 10794544 (1), 17419712 (1)
cardiac hypertrophy	30.5	1	12754996 (1)
chagas disease	30.5	1	19823676 (1)

Genetic Association Database (GAD): ADRB1
Human Genome Epidemiology (HuGE) Navigator: ADRB1 (188 documents)

Export disorders for ADRB1 gene to outside databases

(in PubMed. Associations of this gene to articles via ¹Entrez Gene, ²UniProtKB/Swiss-Prot, ³HGNC, ⁴GAD, ⁵PharmGKB, ⁶HMDB, ⁷DrugBank, ⁸UniProtKB/TrEMBL, ⁹ Novoseek, and/or ¹⁰fRNAdb)
About This Section

PubMed articles for ADRB1 gene, integrated from 9 sources (see all 610):
(articles sorted by number of sources associating them with ADRB1)

Utopia: connect your pdf to the dynamic
world of online information

A polymorphism in the beta1 adrenergic receptor is associated with resting heart rate. (PubMed id 11854867)^{1, 2, 4, 9} Ranade K.... Risch N. (2002)
Association between beta-adrenergic receptor polymorphisms and their G-protein-coupled receptors with body mass index and obesity in women: a report from the NHLBI-sponsored WISE study. (PubMed id 15917856)^{1, 4, 7, 9} Terra S.G....Johnson J.A. (2005)
Gly389Arg polymorphism of beta1-adrenergic receptor is associated with the cardiovascular response to metoprolol. (PubMed id 14534524)^{1, 4, 7, 9} Liu J....Zhou H.H. (2003)
Polymorphisms of genes CYP2D6, ADRB1 and GNAS1 in pharmacokinetics and systemic effects of ophthalmic timolol. A pilot study. (PubMed id 16315032)^{1, 4, 7} Nieminen T....Kahonen M. (2005)
Beta 1-adrenergic receptor polymorphisms and antihypertensive response to metoprolol. (PubMed id 12844134)^{1, 4, 7} Johnson J.A....Pauly D.F. (2003)
A novel polymorphism in the gene coding for the beta(1)-adrenergic receptor associated with survival in patients with heart failure. (PubMed id 11052857)^{1, 2, 4} Borjesson M.... Andersson B. (2000)
Interaction with cystic fibrosis transmembrane conductance regulator- associated ligand (CAL) inhibits beta1-adrenergic receptor surface expression. (PubMed id 15358775)^{1, 2, 9} He J.... Hall R.A. (2004)
Arg389Gly polymorphism of the human beta1-adrenergic receptor in patients with nonfatal acute myocardial infarction. (PubMed id 12851615)^{1, 4, 9} Iwai C....Yokoyama M. (2003)
A gain-of-function polymorphism in a G-protein coupling domain of the human beta1-adrenergic receptor. (PubMed id 10212248)^{1, 2, 9} Mason D.A.... Liggett S.B. (1999)
Beta1-adrenergic receptor polymorphisms and clinical efficacy of betaxolol hydrochloride in normal volunteers. (PubMed id 16325708)^{1, 4, 9} Schwartz S.G....Leffler C.T. (2005)

(in PubMed, OMIM, and NCBI Bookshelf)
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		AND	OR
Aliases
Disorders
Free Text

Query String		PubMed OMIM NCBI Bookshelf
	(Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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Entrez Gene: 153	HGNC: 285	AceView: ADRB1	Ensembl:ENSG00000043591	euGenes: HUgn153
ECgene: ADRB1	Kegg: 153	H-InvDB: ADRB1

(According to HUGE)
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(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section

Name	Description
PharmGKB entry for ADRB1	Pharmacogenomics, SNPs, Pathways
SeattleSNPs	http://pga.gs.washington.edu/data/adrb1/

Intellectual Property for ADRB1 gene
(Patent information from GeneIP, Licensable technologies from WIS Yeda, Salk, Tufts, IP news from LifeMap Sciences, Inc.)

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Patent Information for ADRB1 gene:
Search GeneIP for patents involving ADRB1

GeneCards and IP:
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adrenoceptor beta 1

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HYPERTENSION ARTERIAL
glaucoma
essential hypertension
Glioma
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VENTRICULAR ARRHYTHMIA
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Myocardial Ischemia
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ADRB1 Gene

adrenoceptor beta 1

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