ADRB1 Gene
protein-coding GIFtS : 67
GCID: GC10 P115793
adrenoceptor beta 1 (Previous names: adrenergic, beta-1-, receptor ) (Previous symbol: ADRB1R )
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Aliasesfor ADRB1 gene
(According to
1 HGNC ,
2 Entrez Gene ,
3 UniProtKB/Swiss-Prot ,
4 UniProtKB/TrEMBL , 5 OMIM , 6 GeneLoc ,
7 Ensembl ,
8 DME ,
9 miRBase ,
and/or 10 fRNAdb )About This Section Aliases Adrenoceptor Beta 1 1 2 B1AR2 3 ADRB1R1 2 3 5 RHR2 5 Adrenergic, Beta-1-, Receptor1 2 BETA1AR2 Beta-1 Adrenoceptor2 3 Beta-1 Adrenergic Receptor2 Beta-1 Adrenoreceptor2 3
Export aliases for ADRB1 gene to outside databases Previous GC identifers: GC10P114711 GC10P115037 GC10P115935 GC10P115468 GC10P109429
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Summariesfor ADRB1 gene (According to Entrez Gene ,
Tocris Bioscience ,
Wikipedia's
Gene Wiki ,
PharmGKB ,
UniProtKB/Swiss-Prot ,
and/or
UniProtKB/TrEMBL )
About This Section Entrez Gene summary for ADRB1 : The adrenergic receptors (subtypes alpha 1, alpha 2, beta 1, and beta 2) are a prototypic family of guanine nucleotide binding regulatory protein-coupled receptors that mediate the physiological effects of the hormone epinephrine and the neurotransmitter norepinephrine. Specific polymorphisms in this gene have been shown to affect the resting heart rate and can be involved in heart failure. (provided by RefSeq, Jul 2008) UniProtKB/Swiss-Prot: ADRB1_HUMAN, P08588 Function : Beta-adrenergic receptors mediate the catecholamine-induced activation of adenylate cyclase through theaction of G proteins. This receptor binds epinephrine and norepinephrine with approximately equal affinity summary
for ADRB1 : The adrenergic beta1 receptor (beta1-adrenoceptor) is a member of the adrenergic receptor group ofG-protein-coupled receptors that also includes alpha1A, alpha1B, alpha1D, alpha2A, alpha2B, alpha2C, beta2and beta3. They are located primarily in the CNS, heart, coronary artery, kidney and muscle and are involvedin cardiac stimulation, coronary vasodilation and relaxation of the colon and esophagus. The humanadrenergic beta1 receptor gene has been localized to chromosome 10 (10q24-q26). Gene Wiki entry for ADRB1 (Beta-1 adrenergic receptor) PharmGKB "VIP " summary for
ADRB1
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Genomic Viewsfor ADRB1 gene
(According to
GeneLoc and/or
HGNC , and/or
Entrez Gene (NCBI build 37) ,
and/or miRBase ,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69) ,
Regulatory elements and Epigenetics data according to
QIAGEN ,
SABiosciences , and/or
SwitchGear Genomics )About This Section RefSeq DNA sequence: NC_000010.10 NC_018921.1 NT_030059.13 Regulatory elements: SABiosciences Regulatory transcription factor binding sites in the ADRB1 gene promoter: HFH-3 c-Fos AP-1 C/EBPalpha CREB FOXI1 Pax-3 deltaCREB c-Jun ATF Other transcription factors Search SABiosciences Chromatin IP Primers for ADRB1 Epigenetics: QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human , mouse , rat ADRB1
Genomic Location: Genomic View : UCSC Golden Path with GeneCards custom track Entrez Gene cytogenetic band: 10q25.3 Ensembl cytogenetic band: 10q25.3 HGNC cytogenetic band: 10q25.3 ADRB1 Gene in genomic location: bands according to Ensembl, locations according to
(and/or Entrez Gene and/or Ensembl if different) GeneLoc information about chromosome 10 GeneLoc Exon Structure
GeneLoc location for GC10P115793: view genomic region
(about GC identifiers )
Start:
115,803,806 bp from pter
End:
115,806,667 bp from pter
Size:
2,862 bases
Orientation:
plus strand
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Proteinsfor ADRB1 gene
(According to
1 UniProtKB ,
HORDE ,
neXtProt ,
Ensembl ,
and/or Reactome ,
Modification sites according to 2 PhosphoSitePlus ,
Specific Peptides from DME ,
Protein expression images according to data from SPIRE MOPED and PaxDb ,
RefSeq according to NCBI ,
PDB rendering according to OCA and/or Proteopedia ,
Recombinant Proteins
from
EMD Millipore ,
R&D Systems ,
GenScript ,
Enzo Life Sciences ,
OriGene ,
Novus Biologicals ,
Sino Biological ,
ProSpec , and/or
Uscn ,
Biochemical Assays by
EMD Millipore ,
R&D Systems ,
OriGene ,
GenScript ,
Cell Signaling Technology ,
Enzo Life Sciences , and/or
Uscn ,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene ,
Antibodies by
EMD Millipore ,
R&D Systems ,
GenScript ,
Cell Signaling Technology ,
OriGene ,
Novus Biologicals ,
Thermo Fisher Scientific ,
Abcam , and/or
Uscn )
About This Section UniProtKB/Swiss-Prot: ADRB1_HUMAN, P08588 (See
protein sequence )Recommended Name: Beta-1 adrenergic receptor Size : 477 amino acids; 51323 Da
Subunit : Interacts with GOPC, MAGI3 and DLG4
Subcellular location : Cell membrane; Multi-pass membrane protein. Note=Localized at the plasma membrane. Found in theGolgi upon GOPC overexpression
Secondary accessions : B0LPE2 Q5T5Y4 Q9UKG7 Q9UKG8Explore the universe of human proteins at neXtProt for ADRB1: NX_P08588 Post-translational modifications:
Homologous desensitization of the receptor is mediated by its phosphorylation by beta-adrenergic receptor kinase1
View modification sites using PhosphoSitePlus 2 View neXtProt modification sites for NX_P08588 ADRB1 Protein expression data from MOPED and PaxDb : About this image
REFSEQ proteins: NP_000675.1 ENSEMBL proteins: ENSP00000358301 Reactome Protein details: P08588 Human Recombinant Protein Products: Gene Ontology (GO): 5/6 cellular component terms (GO ID links to tree view) (see all 6 ): About this table
ADRB1 for ontologies About GeneDecksing ADRB1 Antibody Products: Assay Products for ADRB1:
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Protein
Domains / Familiesfor ADRB1 gene (According to InterPro , ProtoNet ,
UniProtKB , and/or BLOCKS ,
Sets of similar genes according to GeneDecks )
About This Section
ADRB1 for domains About GeneDecksing 4 InterPro domains/families :
Graphical View of Domain Structure for InterPro Entry P08588 ProtoNet protein and cluster: P08588
2 Blocks protein families : IPB000507 Beta-1 adrenergic receptor signature IPB002233 Adrenergic receptor signature UniProtKB/Swiss-Prot: ADRB1_HUMAN, P08588 Domain : The PDZ domain-binding motif mediates competitive interactions with GOPC, MAGI3 and DLG4 and plays a role insubcellular location of the receptor Similarity : Belongs to the G-protein coupled receptor 1 family. Adrenergic receptor subfamily. ADRB1 sub-subfamily
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Functionfor ADRB1 gene
(According to 1 UniProtKB ,
Genatlas ,
LifeMap Discovery™ ,
IUBMB , and/or
2 DME ,
Human phenotypes from GenomeRNAi ,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences ,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene ,
RNAi from
EMD Millipore ,
siRNAs from
OriGene ,
QIAGEN ,
microRNA from QIAGEN ,
Gene Editing from DNA2.0 ,
Clones from EMD Millipore ,
OriGene ,
SwitchGear Genomics ,
GenScript ,
Sino Biological ,
DNA2.0 ,
and Vector BioLabs ,
Cell Lines from GenScript ,
LifeMap BioReagents ,
In Situ Hybridization Assays from Advanced Cell Diagnostics ,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene .)
About This Section Function Summary: UniProtKB/Swiss-Prot: ADRB1_HUMAN, P08588 Function : Beta-adrenergic receptors mediate the catecholamine-induced activation of adenylate cyclase through theaction of G proteins. This receptor binds epinephrine and norepinephrine with approximately equal affinity
Genatlas biochemistry entry for ADRB1 : adrenergic,beta-1-,receptor,G protein coupled receptor superfamily,mostly expressed in heart,activating adenylate cyclase,lung,placenta,cerebral cortex,and in other organs mediating the action of catecholamines and sympathetic nervous system,with no apparent association of the C1165G variant with idiopathic cardiomyopathy Clone Products: EMD Millipore Clones for the Expression of ADRB1 OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human , mouse , rat for ADRB1 (see all 3 ) OriGene untagged cDNA clones in CMV expression vector in human , mouse , rat for ADRB1OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling GenScript: all cDNA clones in your preferred vector: ADRB1 (NM_000684 ) Browse Sino Biological Human cDNA Clones DNA2.0 Custom Codon Optimized Gene
Synthesis Service for ADRB1 Search Vector BioLabs for ready-to-use adenovirus/AAV for human, mouse, rat ADRB1
In Situ Assay Products: Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ADRB1
Gene Ontology (GO): 5/10 molecular function terms (GO ID links to tree view) (see all 10 ): About this table
ADRB1 for ontologies About GeneDecksing 1 GenomeRNAi human phenotype for ADRB1 :Animal Models: Mouse knock-out Adrb1 tm1Bkk for ADRB1 9 MGI mutant phenotypes (inferred from 2 alleles ) (MGI details for Adrb1) :
ADRB1 for phenotypes About GeneDecksing
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Pathways & Interactionsfor ADRB1 gene
(Pathways according to
EMD Millipore ,
R&D Systems ,
Cell Signaling Technology ,
KEGG ,
PharmGKB ,
BioSystems ,
Reactome ,
Tocris Bioscience ,
GeneGo (Thomson Reuters) ,
QIAGEN ,
and/or UniProtKB ,
Sets of similar genes according to GeneDecks ,
Interaction Networks according to
SABiosciences ,
and/or STRING ,
Interactions according to 1 UniProtKB ,
2 MINT ,
3 I2D , and/or
4 STRING ,
with links to IntAct and
Ensembl ,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene) .
About This Section Unified GeneCards pathways  - 5/23 super-pathways (see all 23 ) About this table See pathways by source Super-pathway contained gene-specific pathways 1 Class A/1 (Rhodopsin-like receptors) 2 Activation of cAMP-Dependent PKA 3 Signaling by GPCR 4 PKA activation in glucagon signalling 5 Development_Ligand-independent activation of ESR1 and ESR2
Pathway sources See GeneCards unified pathways Show all pathways 5/6 EMD Millipore Pathways for ADRB1 (see all 6 )5/6 Downloadable PowerPoint Slides of QIAGEN Pathway Central Maps for ADRB1 (see all 6 )5/7 GeneGo (Thomson Reuters) Pathways for ADRB1 (see all 7 )4 BioSystems Pathways for ADRB1 5/8
Reactome Pathways for ADRB1 (see all 8 )2 PharmGKB Pathways for ADRB1 5/6
Kegg Pathways (Kegg details for ADRB1) (see all 6 ):
ADRB1 for pathways About GeneDecksing Interactions: SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for ADRB1 STRING Interaction
Network Preview (showing 5 interactants - click image to see 25)5/94 Interacting proteins for ADRB1 (P08588 1 , 2 , 3 ENSP00000358301 4 ) via UniProtKB, MINT, STRING , and/or I2D (see all 94 )Interactant Interaction Details GeneCard External ID(s) MAGI2 Q86UL8 1 , 2 , 3 , ENSP00000346151 4 EBI-991009,EBI-311035 MINT-58358 MINT-58357 MINT-58359 MINT-58360 MINT-58361 I2D:
score=3 STRING: ENSP00000346151 MAGI3 Q5TCQ9 1 , 3 , ENSP00000304604 4 EBI-991009,EBI-991068 I2D:
score=3 STRING: ENSP00000304604 DLG4 P78352 3 , ENSP00000293813 4 I2D:
score=3 STRING: ENSP00000293813 GOPC Q9HD26 3 , ENSP00000357484 4 I2D:
score=3 STRING: ENSP00000357484 GPRASP1 Q5JY77 3 , ENSP00000355146 4 I2D:
score=3 STRING: ENSP00000355146
About this table Gene Ontology (GO): 5/34 biological process terms (GO ID links to tree view) (see all 34 ): About this table
GO ID Qualified GO term Evidence PubMed IDs GO:0001996 positive regulation of heart rate by epinephrine-norepinephrine
IEA -- GO:0001997 positive regulation of the force of heart contraction by epinephrine-norepinephrine
-- -- GO:0002024 diet induced thermogenesis
IEA -- GO:0002025 vasodilation by norepinephrine-epinephrine involved in regulation of systemic arterial blood pressure
IEA -- GO:0003061 positive regulation of the force of heart contraction by norepinephrine
IEA --
ADRB1 for ontologies About GeneDecksing
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Drugs & Compoundsfor ADRB1 gene (Chemical Compounds according to UniProtKB , Enzo Life Sciences ,
EMD Millipore , Tocris Bioscience
HMDB ,
BitterDB , and/or
Novoseek , and Drugs according to
DrugBank ,
Enzo Life Sciences , and/or
PharmGKB , with drugs/clinical trials/news
search links to CenterWatch )
About This Section
ADRB1 for compounds About GeneDecksing Compounds for ADRB1 available from Tocris Bioscience About this table 6 HMDB Compounds for ADRB1 About this table 10/42 DrugBank Compounds for ADRB1 (see all 42 ) About this table 10/53 Novoseek chemical compound relationships for ADRB1 gene (see all 53 ) About this table
Compound
-log (P-Val)
Hits
PubMed IDs for Articles with Shared Sentences (# sentences)
nebivolol
79.1
17
11789394 (1), 17977009 (1), 9010695 (1), 1681809 (1) (see all 15 )
isoproterenol
76.5
42
11705454 (5), 7779864 (2), 14734046 (2), 17067575 (2) (see all 23 )
xamoterol
73.9
9
17067575 (2), 1967560 (2), 1967561 (1), 1967562 (1) (see all 7 )
metoprolol
73
9
11345390 (1), 18702968 (1), 17935678 (1), 11887345 (1) (see all 9 )
zinterol
72.6
5
9915773 (2), 9884381 (1), 1311717 (1)
bucindolol
70.1
3
18403719 (1), 12847069 (1)
atenolol
70
13
18794726 (2), 8386603 (2), 15687340 (1), 12692005 (1) (see all 10 )
betaxolol
68.7
6
16325708 (2), 17635183 (2), 10711687 (1), 10416766 (1)
bisoprolol
65.7
5
17217681 (3), 9832494 (1), 12860977 (1), 11887345 (1)
carvedilol
64.7
9
7908256 (4), 18787115 (1), 18702968 (1), 16475467 (1) (see all 6 )
9 PharmGKB related drug/compound annotations for ADRB1 gene About this table Search CenterWatch for drugs/clinical trials and news about ADRB1
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Transcriptsfor ADRB1 gene (Secondary structures according to
fRNAdb ,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank , RefSeq according to Entrez Gene ,
DOTS (version 10), and/or
AceView ,
transcript ids from Ensembl
with links to UCSC ,
exon structure from GeneLoc ,
alternative splicing isoforms according to ASD and/or
ECgene ,
RNAi Products from
EMD Millipore ,
siRNAs from
OriGene ,
QIAGEN ,
shRNA from
OriGene ,
microRNA from QIAGEN ,
Tagged/untagged cDNA clones from
OriGene ,
SwitchGear Genomics ,
GenScript ,
DNA2.0 ,
Vector BioLabs ,
Primers from
OriGene ,
SABiosciences , and/or
QIAGEN
)About This Section REFSEQ mRNAs for ADRB1 gene: NM_000684.2 Unigene Cluster for ADRB1:
Adrenoceptor beta 1 Hs.99913 [show with all ESTs ] Unigene Representative Sequence: AF272890 1 Ensembl transcript including schematic representation, and UCSC links where relevant : ENST00000369295 (uc001lba.3 ) Clone Products: OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human , mouse , rat for ADRB1 (see all 3 ) OriGene untagged cDNA clones in CMV expression vector in human , mouse , rat for ADRB1OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling GenScript: all cDNA clones in your preferred vector: ADRB1 (NM_000684 ) DNA2.0 Custom Codon Optimized Gene
Synthesis Service for ADRB1 Search Vector BioLabs for ready-to-use adenovirus/AAV for human, mouse, rat ADRB1
Additional cDNA sequence: AF272890.1 J03019.1 U29690.1
2 DOTS entries : DT.92040573 DT.99969854
24/38 AceView cDNA sequences (see all 38 ):
AI003679 BM727728 AW138985 BX279952 BQ023488 AA702310 AW665324 BM681157 AA749352 BF055463 BU665017 AA383612 J03019 BC045633 BI836679 BX097351 AF272890 AI625747 NM_000684 BU633369 BM700625 BF108867 AA011176 C01127 GeneLoc Exon Structure
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Expression for ADRB1 gene
(RNA expression data according to
H-InvDB ,
NONCODE ,
miRBase , and
RNAdb ,
Expression images according to data from
BioGPS ,
Illumina Human BodyMap , and
CGAP
SAGE ,
Sets of similar genes according to GeneDecks ,
in vivo and in vitro expression data from LifeMap Discovery™ ,
plus additional links to
Genevestigator , and/or
SOURCE , and/or
BioGPS , and/or
UniProtKB ,
PCR Arrays from
SABiosciences ,
Primers from
OriGene ,
SABiosciences , and/or
QIAGEN ,
In Situ Hybridization Assays from Advanced Cell Diagnostics )
About This Section ADRB1 expression in normal human tissues (normalized intensities) See probesets specificity/sensitivity at GeneAnnot About this image BioGPS CGAP TAG: TGCAATAAAT
About this image ADRB1 expression in embryonic tissues and stem cells Expression by the Database of Embryonic development, Stem cell research, and
Regenerative medicine About this table 1 LifeMap In Vivo Development Anatomical Compartment/Cell Tissue Anatomical Compartment
Cell Category (developmental path) Placenta Chorioallantoic Placenta Extraembryonic Angioblasts Endothelium Expression: Positive Negative
Selective markerExperimental details:
Curated
Microarrays
In-situ hybridization
See ADRB1 Protein Expression from SPIRE MOPED and PaxDB Genevestigator expression for ADRB1 SOURCE GeneReport for Unigene cluster: Hs.99913 SABiosciences Expression via Pathway-Focused PCR Arrays including ADRB1 : Primer Products: OriGene genome-wide validated SYBR primer pairs in human , mouse , rat for ADRB1Browse OriGene validated miRNA SYBR primer pairs SABiosciences RT2 qPCR Primer Assay in human , mouse , rat ADRB1 QIAGEN QuantiTect SYBR Green Assays in human , mouse , rat ADRB1 QIAGEN QuantiFast Probe-based Assays in human , mouse , rat ADRB1 In Situ Assay Products: Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ADRB1
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Orthologsfor ADRB1 gene
(Orthologs according to
1,2 HomoloGene (2 older version, for species not in 1 newer version),
3 euGenes ,
4 SGD
,
5 MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase ,
and/or
6 Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam )
About This Section
This gene was present in the common ancestor of animals.
Orthologs for ADRB1 gene from 5/18 species (see all 18 ) About this table
Organism
Taxonomic classification
Gene
Description
Human Similarity
Orthology Type
Details
chicken (Gallus gallus)
Aves
ADRB11
adrenoceptor beta 1
68.55(n) 61.28(a)
 
430991 XM_428541.3 XP_428541.3
lizard (Anolis carolinensis)
Reptilia
ADRB16
--
62(a)
1 ↔ 1
GL343204.1(291498-292796)
African clawed frog (Xenopus laevis)
Amphibia
Xl.149922
X.laevis mRNA for beta-1-adrenergic receptor
77.58(n)
 
Y09213.1
zebrafish (Danio rerio)
Actinopterygii
adrb16 adrb16
adrenergic receptor, beta 1
62(a) 62(a)
1 ↔ many1 ↔ many
12(32018119-32019291) 12(32170295-32171515)
fruit fly (Drosophila melanogaster)
Insecta
DopR23 Octbeta2R1
dopamine receptor signaling pathway dopamine receptor3 CG33976-PA1
45(a) (best of 2)3 49.84(n) 1 38.32(a) 1
 
3 99B53 41549 1 NM_001038960.3 1 NP_001034049.1 1
ENSEMBL Gene Tree for ADRB1 (if available)TreeFam Gene Tree for ADRB1 (if available)
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Paralogsfor ADRB1 gene (Paralogs according to
1 HomoloGene , 2 Ensembl , and 3 SIMAP , Pseudogenes according to 4 Pseudogene.org Build 68)About This Section Paralogs for ADRB1 gene TAAR6 2 HTR2A 2 HTR6 2 TAAR2 2 TAAR8 2 HRH2 2 HTR2B 2 DRD1 2 HTR2C 2 TAAR1 2 ADRB2 2 HTR4 2 DRD5 2 ADRB3 2 TAAR5 2 18/25 SIMAP similar genes for ADRB1 using alignment to 1 protein entry: ADRB1_HUMAN (see all similar genes ):ADRB2 hA2aR ADRB3 DRD5P1 HTR1D ADRA1B ADRA1A DRD1 HTR1B HTR5A HRH3 ADRA1D HRH2 HTR1E HTR1F HTR4 HTR4B DRD5
ADRB1 for paralogs About GeneDecksing
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Genomic Variantsfor ADRB1 gene (SNPs/Variants according to the
1 NCBI SNP Database ,
2 Ensembl ,
3 PupaSUITE ,
UniProtKB , and
DNA2.0 ,
Linkage Disequilibrium by HapMap ,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants , Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB) , Blood group antigen gene mutations by BGMUT ,
Resequencing Primers from QIAGEN ,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences )
About This Section
Genomic Data Transcription Related Data Allele Frequencies SNP ID Valid Clinical significance Chr 10 pos Sequence # AA Chg Type More # Allele freq Pop Total sample More
HapMap Linkage Disequilibrium report for ADRB1 (115803806 - 115806667 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions) Database of Genomic Variants (DGV) variations for ADRB1: -- Human Gene Mutation Database (HGMD) : ADRB1 SABiosciences Cancer Mutation PCR Assays
QIAGEN SeqTarget long-range PCR primers in human , mouse , rat for resequencing ADRB1
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Disorders
/ Diseasesfor ADRB1 gene
(in which this Gene is Involved, According to MalaCards ,
OMIM, UniProtKB ,
the University of Copenhagen DISEASES
database , Novoseek ,
Genatlas , GeneTests ,
GAD ,
HuGE Navigator ,
and/or TGDB .)
About This Section
ADRB1 for disorders About GeneDecksing OMIM gene information: 109630 OMIM disorders : 607276 20/65 diseases for ADRB1 (see all 65 ): About MalaCards congestive heart failure and beta-blocker response, modifier of (3) 19 resting heart rate congestive heart failure and beta-blocker response, modifier of congestive heart failure open-angle glaucoma attention deficit hyperactivity disorder congenital aortic valve stenosis aortic valve stenosis long qt syndrome myocardial infarction atrial fibrillation aortic coarctation acute myocardial infarction orthostatic intolerance endomyocardial fibrosis coronary heart disease ventricular tachycardia dilated cardiomyopathy myasthenia gravis sleep apnea 3 diseases from the University of Copenhagen DISEASES database for ADRB1 :Heart disease Hypertension Congenital aortic valve stenosis 10/34 Novoseek disease relationships for ADRB1 gene (see all 34 ) About this table
Disease
-log (P-Val)
Hits
PubMed IDs for Articles with Shared Sentences (# sentences)
heart failure
68.5
50
8522688 (5), 18947427 (4), 19945058 (3), 19010176 (3) (see all 31 )
dilated cardiomyopathy
66.4
16
16153393 (3), 1283934 (2), 12791320 (2), 9846822 (1) (see all 11 )
cardiomyopathy
52.4
8
16412044 (2), 17362986 (1), 9832494 (1), 19158054 (1) (see all 5 )
neuroepithelioma
46.9
3
11705454 (1), 1671088 (1)
resting heart rate
42.3
4
11854867 (3), 16907703 (1)
heart failure congestive
42
8
12422153 (2), 1600963 (1), 12463096 (1), 18325466 (1) (see all 7 )
essential hypertension
34.2
9
18298953 (3), 19743955 (2), 17635183 (1), 20235788 (1) (see all 6 )
heart diseases
33.9
6
16878723 (1), 16816115 (1), 10794544 (1), 17419712 (1)
cardiac hypertrophy
30.5
1
12754996 (1)
chagas disease
30.5
1
19823676 (1)
Genetic Association Database (GAD): ADRB1 Human Genome Epidemiology (HuGE) Navigator: ADRB1 (188 documents) Export disorders for ADRB1 gene to outside databases
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Publicationsfor ADRB1 gene (in
PubMed .
Associations of this gene to articles via
1 Entrez Gene ,
2 UniProtKB/Swiss-Prot ,
3 HGNC ,
4 GAD ,
5 PharmGKB ,
6 HMDB ,
7 DrugBank ,
8 UniProtKB/TrEMBL ,
9 Novoseek , and/or
10 fRNAdb )
About This Section PubMed articles for ADRB1 gene, integrated from 9 sources (see all 610 ): (articles sorted by number of sources associating them with ADRB1) Utopia : connect your pdf to the dynamic world of online information
A polymorphism in the beta1 adrenergic receptor is associated with resting heart rate. (PubMed id 11854867) 1 , 2 , 4, 9 Ranade K.... Risch N. (2002) Association between beta-adrenergic receptor polymorphisms and their G-protein-coupled receptors with body mass index and obesity in women: a report from the NHLBI-sponsored WISE study. (PubMed id 15917856) 1 , 4, 7, 9 Terra S.G....Johnson J.A. (2005) Gly389Arg polymorphism of beta1-adrenergic receptor is associated with the cardiovascular response to metoprolol. (PubMed id 14534524) 1 , 4, 7, 9 Liu J....Zhou H.H. (2003) Polymorphisms of genes CYP2D6, ADRB1 and GNAS1 in pharmacokinetics and systemic effects of ophthalmic timolol. A pilot study. (PubMed id 16315032) 1 , 4, 7 Nieminen T....Kahonen M. (2005) Beta 1-adrenergic receptor polymorphisms and antihypertensive response to metoprolol. (PubMed id 12844134) 1 , 4, 7 Johnson J.A....Pauly D.F. (2003) A novel polymorphism in the gene coding for the beta(1)-adrenergic receptor associated with survival in patients with heart failure. (PubMed id 11052857) 1 , 2 , 4 Borjesson M.... Andersson B. (2000) Interaction with cystic fibrosis transmembrane conductance regulator- associated ligand (CAL) inhibits beta1-adrenergic receptor surface expression. (PubMed id 15358775) 1 , 2 , 9 He J.... Hall R.A. (2004) Arg389Gly polymorphism of the human beta1-adrenergic receptor in patients with nonfatal acute myocardial infarction. (PubMed id 12851615) 1 , 4, 9 Iwai C....Yokoyama M. (2003) A gain-of-function polymorphism in a G-protein coupling domain of the human beta1-adrenergic receptor. (PubMed id 10212248) 1 , 2 , 9 Mason D.A.... Liggett S.B. (1999) Beta1-adrenergic receptor polymorphisms and clinical efficacy of betaxolol hydrochloride in normal volunteers. (PubMed id 16325708) 1 , 4, 9 Schwartz S.G....Leffler C.T. (2005)
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External Searches for ADRB1 gene
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Genome Databases showing ADRB1 gene
(According to
Entrez Gene ,
HGNC ,
AceView ,
euGenes ,
Ensembl ,
miRBase ,
ECgene ,
Kegg ,
and/or
H-InvDB )
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Specialized Databases showing ADRB1 gene (According to PharmGKB ,
ATLAS , HORDE , IMGT , LEIDEN , UniProtKB/Swiss-Prot , and/or UniProtKB/TrEMBL ,Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot )About This Section
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PharmGKB entry for ADRB1 Pharmacogenomics, SNPs, Pathways SeattleSNPs http://pga.gs.washington.edu/data/adrb1/
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About This Section Patent Information for ADRB1 gene: Search GeneIP for patents involving ADRB1 GeneCards and IP: Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
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Productsfor ADRB1 gene (Antibodies, recombinant proteins, and assays from EMD Millipore , R&D Systems , OriGene , QIAGEN , GenScript , Cell Signaling Technology , SABiosciences , Novus Biologicals , Sino Biological , Enzo Life Sciences , Abcam , ProSpec , Uscn , Thermo Fisher Scientific , Gene Editing from DNA2.0 , Clones from EMD Millipore , OriGene , GenScript , Sino Biological , DNA2.0 , SwitchGear Genomics , Vector BioLabs , Cell lines from GenScript and LifeMap BioReagents , PCR Arrays from SABiosciences , Drugs and/or compounds from EMD Millipore , Tocris Bioscience , and/or
Enzo Life Sciences ), In Situ Hybridization Assays from Advanced Cell Diagnostics About This Section
OriGene Antibodies for ADRB1 OriGene shRNA RFP for ADRB1 OriGene 29mer shRNA kits in GFP-retroviral vector in human , mouse , rat for ADRB1 OriGene genome-wide validated SYBR primer pairs in human , mouse , rat for ADRB1 Browse OriGene Protein Over-expression Lysates Browse OriGene Fluorogenic Cell Assay Kits OriGene siRNA for ADRB1 Browse 3'-UTR reporter clones for miRNA target validation OriGene untagged cDNA clones in CMV expression vector in human , mouse , rat for ADRB1 OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human , mouse , rat for ADRB1 Browse OriGene GFP tagged cDNA clones in CMV expression vector Browse OriGene MicroRNA Expression Plasmids Browse OriGene basic RS shRNAs Browse OriGene validated miRNA SYBR primer pairs Browse OriGene full length recombinant human proteins expressed in human HEK293 cells OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling OriGene Custom Antibody Services for ADRB1 OriGene Custom Protein Services for ADRB1 OriGene Custom Immunoassay Development
QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat ADRB1 QIAGEN SeqTarget long-range PCR primers in human , mouse , rat for resequencing ADRB1 QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human , mouse , rat ADRB1 QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human , mouse , rat ADRB1 QIAGEN QuantiFast Probe-based Assays in human , mouse , rat ADRB1 QIAGEN QuantiTect SYBR Green Assays in human , mouse , rat ADRB1
Tocris compounds for ADRB1
Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ADRB1
ThermoFisher Antibody for ADRB1
Search Vector BioLabs for ready-to-use adenovirus/AAV for human, mouse, rat ADRB1
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