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ADRB1 Gene

protein-coding   GIFtS: 69
GCID: GC10P115793

Adrenoceptor Beta 1

(Previous names: adrenergic, beta-1-, receptor)
(Previous symbol: ADRB1R)
  See ADRB1-related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Adrenoceptor Beta 11 2     B1AR2 3
ADRB1R1 2 3 5     RHR2 5
Adrenergic, Beta-1-, Receptor1 2     BETA1AR2
Beta-1 Adrenoceptor2 3     Beta-1 Adrenergic Receptor2
Beta-1 Adrenoreceptor2 3     

External Ids:    HGNC: 2851   Entrez Gene: 1532   Ensembl: ENSG000000435917   OMIM: 1096305   UniProtKB: P085883   

Export aliases for ADRB1 gene to outside databases

Previous GC identifers: GC10P114711 GC10P115037 GC10P115935 GC10P115468 GC10P109429


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for ADRB1 Gene:
The adrenergic receptors (subtypes alpha 1, alpha 2, beta 1, and beta 2) are a prototypic family of guanine
nucleotide binding regulatory protein-coupled receptors that mediate the physiological effects of the hormone
epinephrine and the neurotransmitter norepinephrine. Specific polymorphisms in this gene have been shown to
affect the resting heart rate and can be involved in heart failure. (provided by RefSeq, Jul 2008)

GeneCards Summary for ADRB1 Gene:
ADRB1 (adrenoceptor beta 1) is a protein-coding gene. Diseases associated with ADRB1 include chagas disease, and aortic coarctation. GO annotations related to this gene include drug binding and protein heterodimerization activity. An important paralog of this gene is TAAR6.

UniProtKB/Swiss-Prot: ADRB1_HUMAN, P08588
Function: Beta-adrenergic receptors mediate the catecholamine-induced activation of adenylate cyclase through the
action of G proteins. This receptor binds epinephrine and norepinephrine with approximately equal affinity.
Mediates Ras activation through G(s)-alpha- and cAMP-mediated signaling

summary for ADRB1 Gene:
The adrenergic beta1 receptor (beta1-adrenoceptor) is a member of the adrenergic receptor group of
G-protein-coupled receptors that also includes alpha1A, alpha1B, alpha1D, alpha2A, alpha2B, alpha2C, beta2
and beta3. They are located primarily in the CNS, heart, coronary artery, kidney and muscle and are involved
in cardiac stimulation, coronary vasodilation and relaxation of the colon and esophagus. The human
adrenergic beta1 receptor gene has been localized to chromosome 10 (10q24-q26).

Gene Wiki entry for ADRB1 (Beta-1 adrenergic receptor) Gene

PharmGKB "VIP" summary for ADRB1


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence:
NC_000010.11  NC_018921.2  NT_030059.14  
Regulatory elements:
   Regulatory transcription factor binding sites in the ADRB1 gene promoter:
         HFH-3   c-Fos   AP-1   C/EBPalpha   CREB   FOXI1   Pax-3   deltaCREB   c-Jun   ATF   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidADRB1 promoter sequence
   Search Chromatin IP Primers for ADRB1

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat ADRB1


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 10q25.3   Ensembl cytogenetic band:  10q25.3   HGNC cytogenetic band: 10q25.3

ADRB1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
ADRB1 gene location

GeneLoc information about chromosome 10         GeneLoc Exon Structure

GeneLoc location for GC10P115793:  view genomic region     (about GC identifiers)

Start:
115,803,806 bp from pter      End:
115,806,667 bp from pter
Size:
2,862 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., and/or eBioscience,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., and/or eBioscience, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: ADRB1_HUMAN, P08588 (See protein sequence)
Recommended Name: Beta-1 adrenergic receptor  
Size: 477 amino acids; 51323 Da
Subunit: Interacts (via C-terminus PDZ motif) with RAPGEF2; the interaction is direct. Interacts with GOPC, MAGI3
and DLG4
1 PDB 3D structure from and Proteopedia for ADRB1:
2LSQ (3D)    
Secondary accessions: B0LPE2 Q5T5Y4 Q9UKG7 Q9UKG8

Explore the universe of human proteins at neXtProt for ADRB1: NX_P08588

Explore proteomics data for ADRB1 at MOPED

Post-translational modifications: 

  • Homologous desensitization of the receptor is mediated by its phosphorylation by beta-adrenergic receptor kinase1
  • Glycosylation2 at Asn15
  • Modification sites at PhosphoSitePlus

  • See ADRB1 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_000675.1  
    ENSEMBL proteins: 
     ENSP00000358301  
    Reactome Protein details: P08588

    ADRB1 Human Recombinant Protein Products:

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    Browse Sino Biological Cell Lysates
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    Browse Proteins at Cloud-Clone Corp.

     
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    Search eBioscience for ELISAs for ADRB1 


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    ADRB: GPCR / Class A : Adrenoceptors : beta

    IUPHAR Guide to PHARMACOLOGY protein family classification: beta1-adrenoceptor
    Adrenoceptors

    4 InterPro protein domains:
     IPR017452 GPCR_Rhodpsn_7TM
     IPR000507 ADRB1_rcpt
     IPR002233 ADR_fam
     IPR000276 GPCR_Rhodpsn

    Graphical View of Domain Structure for InterPro Entry P08588

    ProtoNet protein and cluster: P08588

    2 Blocks protein domains:
    IPB000507 Beta-1 adrenergic receptor signature
    IPB002233 Adrenergic receptor signature


    UniProtKB/Swiss-Prot: ADRB1_HUMAN, P08588
    Domain: The PDZ domain-binding motif mediates competitive interactions with GOPC, MAGI3 and DLG4 and plays a role
    in subcellular location of the receptor
    Similarity: Belongs to the G-protein coupled receptor 1 family. Adrenergic receptor subfamily. ADRB1 sub-subfamily


    Find genes that share domains with ADRB1           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: ADRB1_HUMAN, P08588
    Function: Beta-adrenergic receptors mediate the catecholamine-induced activation of adenylate cyclase through the
    action of G proteins. This receptor binds epinephrine and norepinephrine with approximately equal affinity.
    Mediates Ras activation through G(s)-alpha- and cAMP-mediated signaling

         Genatlas biochemistry entry for ADRB1:
    adrenergic,beta-1-,receptor,G protein coupled receptor superfamily,mostly expressed in heart,activating adenylate
    cyclase,lung,placenta,cerebral cortex,and in other organs mediating the action of catecholamines and sympathetic
    nervous system,with no apparent association of the C1165G variant with idiopathic cardiomyopathy

         Gene Ontology (GO): Selected molecular function terms (see all 13):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0004930G-protein coupled receptor activity ----
    GO:0004939beta-adrenergic receptor activity TAS8892658
    GO:0004940beta1-adrenergic receptor activity IEA--
    GO:0005057receptor signaling protein activity IDA12391161
    GO:0005088Ras guanyl-nucleotide exchange factor activity IDA12391161
         
    Find genes that share ontologies with ADRB1           About GenesLikeMe


    Phenotypes:
         1 GenomeRNAi human phenotype for ADRB1:
     Increased gamma-H2AX phosphory 

         9 MGI mutant phenotypes (inferred from 2 alleles(MGI details for Adrb1):
     adipose tissue  cardiovascular system  endocrine/exocrine gland  growth/size/body  homeostasis/metabolism 
     mortality/aging  muscle  no phenotypic analysis  skeleton 

    Find genes that share phenotypes with ADRB1           About GenesLikeMe

    Animal Models:
         MGI mouse knock-out Adrb1tm1Bkk for ADRB1

       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for ADRB1
       inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for ADRB1

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for ADRB1
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for ADRB1

    miRNA
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    Selected qRT-PCR Assays for microRNAs that regulate ADRB1 (see all 65):
    hsa-miR-520e hsa-miR-199a-3p hsa-miR-200a hsa-miR-374a hsa-miR-30d hsa-miR-342-3p hsa-miR-890 hsa-miR-1244
    SwitchGear 3'UTR luciferase reporter plasmidADRB1 3' UTR sequence
    Inhib. RNA
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    Predesigned siRNA for gene silencing in human, mouse, rat ADRB1

    Gene Editing
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    Clone
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    GenScript: all cDNA clones in your preferred vector: ADRB1 (NM_000684)
    Browse Sino Biological Human cDNA Clones
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for ADRB1
    Search Vector BioLabs for ready-to-use adenovirus/AAV for human, mouse, rat ADRB1
    Addgene plasmids for ADRB1 

    Cell Line
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    In Situ Assay
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ADRB1


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    ADRB1_HUMAN, P08588: Cell membrane; Multi-pass membrane protein. Early endosome. Note=Colocalizes with RAPGEF2 at
    the plasma membrane (By similarity). Localized at the plasma membrane. Found in the Golgi upon GOPC
    overexpression
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    plasma membrane5
    endoplasmic reticulum2
    extracellular2
    nucleus2
    cytoskeleton1

    Gene Ontology (GO): Selected cellular component terms (see all 8):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus IEA--
    GO:0005737cytoplasm ----
    GO:0005769early endosome IDA--
    GO:0005886plasma membrane TAS--
    GO:0005887integral component of plasma membrane TAS10212248

    Find genes that share ontologies with ADRB1           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for ADRB1 About   (see all 24)  
    See pathways by source

    SuperPathContained pathways About
    1Peptide ligand-binding receptors
    Class A/1 (Rhodopsin-like receptors)0.71
    GPCRs, Class A Rhodopsin-like0.43
    GPCR ligand binding0.71
    Neuroactive ligand-receptor interaction0.36
    2Monoamine GPCRs
    Monoamine GPCRs0.79
    Adrenoceptors0.00
    Amine ligand-binding receptors0.79
    3Ca-dependent events
    Beta 2 adrenergic dependent CFTR expression0.50
    Development Beta adrenergic receptors signaling via cAMP0.32
    4Signaling in Gap Junctions
    Gap junction0.31
    Signaling in Gap Junctions0.31
    5Signaling by GPCR
    Signaling by GPCR0.90
    Signal Transduction0.58
    GPCR downstream signaling0.90


    Find genes that share SuperPaths with ADRB1           About GenesLikeMe

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    Selected Downloadable PowerPoint Slides of GeneGlobe Pathway Central Maps for ADRB1 (see all 6)
        Activation of PKA through GPCR
    cAMP Pathway
    Activation of cAMP-Dependent PKA
    Signaling in Gap Junctions
    Signaling Involved in Cardiac Hypertrophy

    2 Cell Signaling Technology (CST) Pathways for ADRB1
        Ca, cAMP and Lipid Signaling
    Neuroscience

    Selected GeneGo (Thomson Reuters) Pathways for ADRB1 (see all 7)
        G-protein signaling H-RAS regulation pathway
    Development Ligand-independent activation of ESR1 and ESR2
    Development Beta-adrenergic receptors signaling via cAMP
    Beta-2 adrenergic-dependent CFTR expression
    G-protein signaling Rap2B regulation pathway

    4 BioSystems Pathways for ADRB1
        Calcium Regulation in the Cardiac Cell
    GPCRs, Class A Rhodopsin-like
    Endothelin
    Monoamine GPCRs

    2 Reactome Pathways for ADRB1
        G alpha (s) signalling events
    Adrenoceptors

    2 PharmGKB Pathways for ADRB1
        Antiarrhythmic Pathway, Pharmacodynamics
    Sympathetic Nerve Pathway (Neuroeffector Junction)

    Selected Kegg Pathways  (Kegg details for ADRB1) (see all 7):
        Calcium signaling pathway
    Neuroactive ligand-receptor interaction
    Endocytosis
    Adrenergic signaling in cardiomyocytes
    Gap junction

        Pathway & Disease-focused RT2 Profiler PCR Arrays including ADRB1: 
              cAMP / Ca2+ Signaling PathwayFinder in human mouse rat
              G-Protein-Coupled Receptor Signaling PathwayFinder in human mouse rat
              G Protein Coupled Receptors 384HT in human mouse rat
              Hypertension in human mouse rat
              Obesity in human mouse rat

    Interactions:

        GeneGlobe Interaction Network for ADRB1

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for ADRB1 (P085881, 2, 3 ENSP000003583014) via UniProtKB, MINT, STRING, and/or I2D (see all 111)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    MAGI2Q86UL81, 2, 3, ENSP000003461514EBI-991009,EBI-311035 MINT-58358 MINT-58357 MINT-58359 MINT-58360 MINT-58361 I2D: score=3 STRING: ENSP00000346151
    MAGI3Q5TCQ91, 3, ENSP000003046044EBI-991009,EBI-310506 I2D: score=3 STRING: ENSP00000304604
    GOPCQ9HD263, ENSP000003574844I2D: score=3 STRING: ENSP00000357484
    GPRASP1Q5JY773, ENSP000003551464I2D: score=3 STRING: ENSP00000355146
    GPRASP2Q96D093, ENSP000003390574I2D: score=3 STRING: ENSP00000339057
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 38):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0001996positive regulation of heart rate by epinephrine-norepinephrine IEA--
    GO:0001997positive regulation of the force of heart contraction by epinephrine-norepinephrine ----
    GO:0002024diet induced thermogenesis IEA--
    GO:0002025vasodilation by norepinephrine-epinephrine involved in regulation of systemic arterial blood pressure IEA--
    GO:0003061positive regulation of the force of heart contraction by norepinephrine IEA--

    Find genes that share ontologies with ADRB1           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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      Browse compounds at ApexBio 

    Compounds for ADRB1 available from Tocris Bioscience    About this table
    CompoundAction CAS #
    Betaxolol hydrochlorideSelective beta1 antagonist[63659-19-8]
    (+-)-Bisoprolol hemifumaratebeta1 antagonist[104344-23-2]
    Nebivolol hydrochlorideHighly selective beta1-adrenoceptor antagonist[152520-56-4]
    Xamoterol hemifumaratebeta1 selective partial agonist[73210-73-8]
    CGP 20712 dihydrochlorideHighly potent and selective beta1 antagonist[1216905-73-5]

    6 HMDB Compounds for ADRB1    About this table
    CompoundSynonyms CAS #PubMed Ids
    AtenololAircrit (see all 104)29122-68-7--
    Epinephrine(-)-(R)-Epinephrine (see all 72)51-43-4--
    Metoprolol(+/-)-Metoprolol (see all 19)37350-58-6--
    Norepinephrine(-)-(R)-Norepinephrine (see all 32)51-41-2--
    PropranololDociton (see all 8)525-66-6--
    RisperidoneBelivon (see all 7)106266-06-2--

    Selected DrugBank Compounds for ADRB1 (see all 44)    About this table
    CompoundSynonyms CAS #TypeActionsPubMed Ids
    LabetalolLabetalol HCL (see all 4)36894-69-6targetantagonist19879818 7286847 6151824 6355664 11752352 7684671 8104240 1687367
    AlprenololAlfeprol [Russian] (see all 3)13655-52-2targetantagonist10433496 2828119 12522078 11752352 7606348 7678677
    BisoprololBisoprolol Fumarate (see all 3)66722-44-9targetantagonist16325050 1280737 14757145 1676675 11752352 1691366
    Bopindolol-- 69010-88-4targetpartial agonist1687398 8884690 2907348 2148726 11752352 14608456
    Esmolol-- 103598-03-4targetantagonist2894187 11752352 7957532 1975995 2568748 7612051
    LevobunololLevobunolol HCl (see all 2)47141-42-4targetantagonist7928182 10864881 2891463 2892662 1351412 11572462
    Metoprolol-- 37350-58-6targetantagonist12844134 10913016 11448474 12679135 11752352 14534524
    Nadolol-- 42200-33-9targetantagonist10433496 7981009 7912539 11752352 1354084 10606440
    Oxprenolol(+-)-oxprenolol (see all 9)6452-71-7targetantagonist6124492 17139284 2871880 11752352 17016423 6202960
    PindololBetapindol (see all 2)13523-86-9targetpartial agonist1687398 8884690 2907348 2148726 11752352 14608456

    Selected IUPHAR Ligands for ADRB1 (beta1-adrenoceptor) (see all 28)    About this table
    LigandTypeActionAffinityPubmed IDs
    [125I]ICYP
    AntagonistAntagonist10.5 - 11.38982677 10079020
    [125I](-)ICYP
    AntagonistAntagonist10 - 11.315037517 8982677 10079020 10531390
    carvedilol
    AntagonistAntagonist9.510411574
    CGP 12177
    AntagonistAntagonist8.8 - 9.315655528 15060759
    CGP 20712A
    AntagonistAntagonist8.5 - 9.210079020 15655528 10411574
    [3H](-)CGP 12177
    AntagonistAntagonist6.6 - 9.215655528 15060759
    bupranolol
    AntagonistAntagonist7.3 - 910079020 10411574
    (-)-propranolol
    AntagonistAntagonist8.2 - 8.910079020 15655528 15060759
    betaxolol
    AntagonistAntagonist8.810079020
    SR59230A
    AntagonistAntagonist8.610411574

    Selected Novoseek inferred chemical compound relationships for ADRB1 gene (see all 53)    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    nebivolol 79.1 17 11789394 (1), 17977009 (1), 9010695 (1), 1681809 (1) (see all 15)
    isoproterenol 76.5 42 11705454 (5), 7779864 (2), 14734046 (2), 17067575 (2) (see all 23)
    xamoterol 73.9 9 17067575 (2), 1967560 (2), 1967561 (1), 1967562 (1) (see all 7)
    metoprolol 73 9 11345390 (1), 18702968 (1), 17935678 (1), 11887345 (1) (see all 9)
    zinterol 72.6 5 9915773 (2), 9884381 (1), 1311717 (1)
    bucindolol 70.1 3 18403719 (1), 12847069 (1)
    atenolol 70 13 18794726 (2), 8386603 (2), 15687340 (1), 12692005 (1) (see all 10)
    betaxolol 68.7 6 16325708 (2), 17635183 (2), 10711687 (1), 10416766 (1)
    bisoprolol 65.7 5 17217681 (3), 9832494 (1), 12860977 (1), 11887345 (1)
    carvedilol 64.7 9 7908256 (4), 18787115 (1), 18702968 (1), 16475467 (1) (see all 6)

    Selected PharmGKB related drug/compound annotations for ADRB1 gene (see all 10)    About this table
    Drug/compound PharmGKB Annotation
    AntihypertensivesCA  
    Beta Blocking AgentsCA  
    atenololCA  
    bisoprololCA  
    bucindololCA  
    carvedilolCA  
    dobutamineCA  
    metoprololCA  
    muraglitazarCA  
    verapamilCA  



    Find genes that share compounds with ADRB1           About GenesLikeMe



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for ADRB1 gene: 
    NM_000684.2  

    Unigene Cluster for ADRB1:

    Adrenoceptor beta 1
    Hs.99913  [show with all ESTs]
    Unigene Representative Sequence: AF272890
    1 Ensembl transcript including schematic representation, and UCSC links where relevant:
    ENST00000369295(uc001lba.3)
    miRNA
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    GenScript: all cDNA clones in your preferred vector: ADRB1 (NM_000684)
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    Addgene plasmids for ADRB1 
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      QuantiTect SYBR Green Assays in human, mouse, rat ADRB1
      QuantiFast Probe-based Assays in human, mouse, rat ADRB1

    Additional mRNA sequence: 

    AF272890.1 J03019.1 U29690.1 

    2 DOTS entries:

    DT.92040573  DT.99969854 

    Selected AceView cDNA sequences (see all 38):

    BM727728 BX279952 AA702310 AW665324 AW138985 AA749352 BM681157 BQ023488 
    AI003679 J03019 AA383612 AI625747 BI836679 BF055463 BX097351 AF272890 
    BU665017 BC045633 NM_000684 BU633369 BM700625 AA011176 BF108867 AA748431 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

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    ADRB1 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: TGCAATAAAT
    ADRB1 Expression
    About this image


    ADRB1 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 4) fully expand
     
     Peripheral Nervous System (Nervous System)
             Schwann Precursor Cells Peripheral Nerve Domain
     
     Epiblast (Early Embryonic Tissues)
             Epiblast Stem Cell line 7
     
     Heart (Cardiovascular System)
     
     Lung (Respiratory System)
    ADRB1 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    ADRB1 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.99913
        Pathway & Disease-focused RT2 Profiler PCR Arrays including ADRB1: 
              cAMP / Ca2+ Signaling PathwayFinder in human mouse rat
              G-Protein-Coupled Receptor Signaling PathwayFinder in human mouse rat
              G Protein Coupled Receptors 384HT in human mouse rat
              Hypertension in human mouse rat
              Obesity in human mouse rat

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    In Situ
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ADRB1

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

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    This gene was present in the common ancestor of animals.

    Orthologs for ADRB1 gene from Selected species (see all 15)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Adrb11 , 5 adrenergic receptor, beta 11, 5 88.82(n)1
    90.32(a)1
      19 (51.96 cM)5
    115541  NM_007419.21  NP_031445.21 
     567223725 
    chicken
    (Gallus gallus)
    Aves ADRB11 adrenoceptor beta 1 75.32(n)
    70.23(a)
      101750705  XM_004942287.1  XP_004942344.1 
    lizard
    (Anolis carolinensis)
    Reptilia ADRB16
    adrenoceptor beta 1
    63(a)
    1 ↔ 1
    GL343204.1(291498-292796)
    African clawed frog
    (Xenopus laevis)
    Amphibia Xl.149922 X.laevis mRNA for beta-1-adrenergic receptor 77.58(n)    Y09213.1 
    zebrafish
    (Danio rerio)
    Actinopterygii adrb11 adrenergic receptor, beta 1 66.03(n)
    64.66(a)
      557194  NM_001128689.1  NP_001122161.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta DopR21 , 3 dopamine receptor signaling pathway
    dopamine receptor3
    Dopamine receptor 21
    45(a)
    (best of 2)3
    56.98(n)1
    45.26(a)1
      3 99B53
    434841  NM_170420.21  NP_733299.11 


    ENSEMBL Gene Tree for ADRB1 (if available)
    TreeFam Gene Tree for ADRB1 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for ADRB1 gene
    TAAR62  HTR62  TAAR22  TAAR92  TAAR82  HRH22  DRD12  TAAR12  
    ADRB22  HTR42  ADRB32  DRD52  TAAR52  
    Selected SIMAP similar genes for ADRB1 using alignment to 1 protein entry:     ADRB1_HUMAN(see all similar genes):
    ADRB2    hA2aR    ADRB3    DRD5P1    HTR1D    ADRA1B
    ADRA1A    DRD1    HTR1B    HTR5A    HRH3    ADRA1D
    HRH2    HTR1E    HTR1F    HTR4    HTR4B    DRD5

    Find genes that share paralogs with ADRB1           About GenesLikeMe



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for ADRB1 (see all 146)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 10 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs18012531,2,,4
    C,F,A,Hdrug-response1116160957(+) TCCAGC/GGACTG 2 R G mis134Minor allele frequency- G:0.31NS NA EA MN CSA WA EU 22948
    rs18012521,2,,4
    C,F,A,Hpathogenic1116159937(+) GCGAAA/GGCCCC 2 S G mis1 ese327Minor allele frequency- G:0.16EA MN NS NA WA 21670
    rs1903481621,2
    --109427484(+) CAGTGA/GGCCAA 1 -- us2k10--------
    rs1830171021,2
    --109427496(+) ATCACA/GCCACT 1 -- us2k10--------
    rs1877429891,2
    --109427523(+) AACAAA/GAGTGA 1 -- us2k10--------
    rs20503951,2
    C,F,A--109427578(-) CACTGA/CAAGCC 1 -- us2k19Minor allele frequency- C:0.19NA NS CSA WA EA 457
    rs1932783361,2
    --109427641(+) TTTCCG/TGGCCA 1 -- us2k10--------
    rs1489263651,2
    --109427726(+) CCAGTC/TTTAAC 1 -- us2k10--------
    rs178754391,2
    C,F--109427733(+) TAACAT/CACTGA 1 -- us2k1 tfbs38Minor allele frequency- C:0.10NS NA CSA WA EA 450
    rs178754461,2
    C,F--115806232(+) AAAAA-/A/CGGAGT 2 -- ut31 trp33NS 564

    HapMap Linkage Disequilibrium report for ADRB1 (115803806 - 115806667 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 7 variations for ADRB1:    About this table    
    Variant IDTypeSubtypePubMed ID
    nsv896017CNV Loss21882294
    nsv896021CNV Loss21882294
    nsv896025CNV Loss21882294
    dgv823n71CNV Loss21882294
    dgv824n71CNV Loss21882294
    dgv825n71CNV Loss21882294
    nsv7211OTHER Inversion18451855

    Human Gene Mutation Database (HGMD): ADRB1
    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing ADRB1
    DNA2.0 Custom Variant and Variant Library Synthesis for ADRB1

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section

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    OMIM gene information: 109630   
    OMIM disorders: 607276  
    15 diseases for ADRB1:    
    About MalaCards
    chagas disease    aortic coarctation    meningococcal infection    congestive heart failure and beta-blocker response, modifier of
    endomyocardial fibrosis    neuroepithelioma    syncope    congestive heart failure
    obstructive sleep apnea    orthostatic intolerance    myocarditis    essential hypertension
    coronary artery disease    myocardial infarction    obesity

    2 diseases from the University of Copenhagen DISEASES database for ADRB1:
    Heart disease     Hypertension

    Find genes that share disorders with ADRB1           About GenesLikeMe

    Selected Novoseek inferred disease relationships for ADRB1 gene (see all 34)    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    heart failure 68.5 50 8522688 (5), 18947427 (4), 19945058 (3), 19010176 (3) (see all 31)
    dilated cardiomyopathy 66.4 16 16153393 (3), 1283934 (2), 12791320 (2), 9846822 (1) (see all 11)
    cardiomyopathy 52.4 8 16412044 (2), 17362986 (1), 9832494 (1), 19158054 (1) (see all 5)
    neuroepithelioma 46.9 3 11705454 (1), 1671088 (1)
    resting heart rate 42.3 4 11854867 (3), 16907703 (1)
    heart failure congestive 42 8 12422153 (2), 1600963 (1), 12463096 (1), 18325466 (1) (see all 7)
    essential hypertension 34.2 9 18298953 (3), 19743955 (2), 17635183 (1), 20235788 (1) (see all 6)
    heart diseases 33.9 6 16878723 (1), 16816115 (1), 10794544 (1), 17419712 (1)
    cardiac hypertrophy 30.5 1 12754996 (1)
    chagas disease 30.5 1 19823676 (1)

    Genetic Association Database (GAD): ADRB1
    Human Genome Epidemiology (HuGE) Navigator: ADRB1 (188 documents)

    Export disorders for ADRB1 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for ADRB1 gene, integrated from 10 sources (see all 642):
    (articles sorted by number of sources associating them with ADRB1)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. A polymorphism in the beta1 adrenergic receptor is associated with resting heart rate. (PubMed id 11854867)1, 2, 4, 9 Ranade K.... Risch N. (Am. J. Hum. Genet. 2002)
    2. Association between beta-adrenergic receptor polymorphisms and their G-protein-coupled receptors with body mass index and obesity in women: a report from the NHLBI-sponsored WISE study. (PubMed id 15917856)1, 4, 7, 9 Terra S.G....Johnson J.A. (Int J Obes (Lond) 2005)
    3. Gly389Arg polymorphism of beta1-adrenergic receptor is associated with the cardiovascular response to metoprolol. (PubMed id 14534524)1, 4, 7, 9 Liu J....Zhou H.H. (Clin. Pharmacol. Ther. 2003)
    4. In patients chronically treated with metoprolol, the demand of inotropic catecholamine support after coronary artery bypass grafting is determined by the Arg389Gly-beta 1-adrenoceptor polymorphism. (PubMed id 17541557)1, 4, 7 Leineweber K....Brodde O.E. (Naunyn Schmiedebergs Arch. Pharmacol. 2007)
    5. Polymorphisms of genes CYP2D6, ADRB1 and GNAS1 in pharmacokinetics and systemic effects of ophthalmic timolol. A pilot study. (PubMed id 16315032)1, 4, 7 Nieminen T....KAohAPnen M. (Eur. J. Clin. Pharmacol. 2005)
    6. Beta 1-adrenergic receptor polymorphisms and antihypertensive response to metoprolol. (PubMed id 12844134)1, 4, 7 Johnson J.A....Pauly D.F. (Clin. Pharmacol. Ther. 2003)
    7. A novel polymorphism in the gene coding for the beta(1)-adrenergic receptor associated with survival in patients with heart failure. (PubMed id 11052857)1, 2, 4 Borjesson M.... Andersson B. (Eur. Heart J. 2000)
    8. Interaction with cystic fibrosis transmembrane conductance regulator- associated ligand (CAL) inhibits beta1-adrenergic receptor surface expression. (PubMed id 15358775)1, 2, 9 He J.... Hall R.A. (J. Biol. Chem. 2004)
    9. Direct binding of the beta1 adrenergic receptor to the cyclic AMP-dependent guanine nucleotide exchange factor CNrasGEF leads to Ras activation. (PubMed id 12391161)1, 2, 9 Pak Y....Rotin D. (Mol. Cell. Biol. 2002)
    10. Arg389Gly polymorphism of the human beta1-adrenergic receptor in patients with nonfatal acute myocardial infarction. (PubMed id 12851615)1, 4, 9 Iwai C....Yokoyama M. (Am. Heart J. 2003)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 153 HGNC: 285 AceView: ADRB1 Ensembl:ENSG00000043591 euGenes: HUgn153
    ECgene: ADRB1 Kegg: 153 H-InvDB: ADRB1

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
    About This Section

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    NameDescription
    PharmGKB entry for ADRB1 Pharmacogenomics, SNPs, Pathways
    SeattleSNPshttp://pga.gs.washington.edu/data/adrb1/

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for ADRB1 gene:
    Search GeneIP for patents involving ADRB1

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, eBioscience, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
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