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Aliases for ADRB1 Gene

Aliases for ADRB1 Gene

  • Adrenoceptor Beta 1 2 3
  • Adrenergic, Beta-1-, Receptor 2 3
  • Beta-1 Adrenoreceptor 3 4
  • Beta-1 Adrenoceptor 3 4
  • ADRB1R 3 4
  • B1AR 3 4
  • BETA1AR 3
  • RHR 3

External Ids for ADRB1 Gene

Previous HGNC Symbols for ADRB1 Gene

  • ADRB1R

Previous GeneCards Identifiers for ADRB1 Gene

  • GC10P114711
  • GC10P115037
  • GC10P115935
  • GC10P115468
  • GC10P115793
  • GC10P109429

Summaries for ADRB1 Gene

Entrez Gene Summary for ADRB1 Gene

  • The adrenergic receptors (subtypes alpha 1, alpha 2, beta 1, and beta 2) are a prototypic family of guanine nucleotide binding regulatory protein-coupled receptors that mediate the physiological effects of the hormone epinephrine and the neurotransmitter norepinephrine. Specific polymorphisms in this gene have been shown to affect the resting heart rate and can be involved in heart failure. [provided by RefSeq, Jul 2008]

GeneCards Summary for ADRB1 Gene

ADRB1 (Adrenoceptor Beta 1) is a Protein Coding gene. Diseases associated with ADRB1 include ocular hypotension and coronary artery disease. Among its related pathways are Signaling by GPCR and Activation of cAMP-Dependent PKA. GO annotations related to this gene include G-protein coupled receptor activity and PDZ domain binding. An important paralog of this gene is ADRB3.

UniProtKB/Swiss-Prot for ADRB1 Gene

  • Beta-adrenergic receptors mediate the catecholamine-induced activation of adenylate cyclase through the action of G proteins. This receptor binds epinephrine and norepinephrine with approximately equal affinity. Mediates Ras activation through G(s)-alpha- and cAMP-mediated signaling.

Tocris Summary for ADRB1 Gene

  • The adrenergic beta1 receptor (beta1-adrenoceptor) is a member of the adrenergic receptor group of G-protein-coupled receptors that also includes alpha1A, alpha1B, alpha1D, alpha2A, alpha2B, alpha2C, beta2 and beta3. They are located primarily in the CNS, heart, coronary artery, kidney and muscle.

Gene Wiki entry for ADRB1 Gene

No data available for PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ADRB1 Gene

Genomics for ADRB1 Gene

Regulatory Elements for ADRB1 Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for ADRB1 Gene

Chromosome:
10
Start:
114,044,047 bp from pter
End:
114,046,908 bp from pter
Size:
2,862 bases
Orientation:
Plus strand

Genomic View for ADRB1 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for ADRB1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ADRB1 Gene

Proteins for ADRB1 Gene

  • Protein details for ADRB1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P08588-ADRB1_HUMAN
    Recommended name:
    Beta-1 adrenergic receptor
    Protein Accession:
    P08588
    Secondary Accessions:
    • B0LPE2
    • Q5T5Y4
    • Q9UKG7
    • Q9UKG8

    Protein attributes for ADRB1 Gene

    Size:
    477 amino acids
    Molecular mass:
    51323 Da
    Quaternary structure:
    • Interacts (via C-terminus PDZ motif) with RAPGEF2; the interaction is direct. Interacts with GOPC, MAGI3 and DLG4.

    Three dimensional structures from OCA and Proteopedia for ADRB1 Gene

neXtProt entry for ADRB1 Gene

Proteomics data for ADRB1 Gene at MOPED

Post-translational modifications for ADRB1 Gene

  • Homologous desensitization of the receptor is mediated by its phosphorylation by beta-adrenergic receptor kinase
  • Glycosylation at Asn 15
  • Modification sites at PhosphoSitePlus

Other Protein References for ADRB1 Gene

ENSEMBL proteins:
REFSEQ proteins:

Antibody Products

  • Cell Signaling Technology (CST) Antibodies for ADRB1 (ADRB1)

No data available for DME Specific Peptides for ADRB1 Gene

Domains & Families for ADRB1 Gene

Gene Families for ADRB1 Gene

Suggested Antigen Peptide Sequences for ADRB1 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

P08588

UniProtKB/Swiss-Prot:

ADRB1_HUMAN :
  • The PDZ domain-binding motif mediates competitive interactions with GOPC, MAGI3 and DLG4 and plays a role in subcellular location of the receptor
  • Belongs to the G-protein coupled receptor 1 family. Adrenergic receptor subfamily. ADRB1 sub-subfamily.
Domain:
  • The PDZ domain-binding motif mediates competitive interactions with GOPC, MAGI3 and DLG4 and plays a role in subcellular location of the receptor
Family:
  • Belongs to the G-protein coupled receptor 1 family. Adrenergic receptor subfamily. ADRB1 sub-subfamily.
genes like me logo Genes that share domains with ADRB1: view

Function for ADRB1 Gene

Molecular function for ADRB1 Gene

GENATLAS Biochemistry:
adrenergic,beta-1-,receptor,G protein coupled receptor superfamily,mostly expressed in heart,activating adenylate cyclase,lung,placenta,cerebral cortex,and in other organs mediating the action of catecholamines and sympathetic nervous system,with no apparent association of the C1165G variant with idiopathic cardiomyopathy
UniProtKB/Swiss-Prot Function:
Beta-adrenergic receptors mediate the catecholamine-induced activation of adenylate cyclase through the action of G proteins. This receptor binds epinephrine and norepinephrine with approximately equal affinity. Mediates Ras activation through G(s)-alpha- and cAMP-mediated signaling.

Gene Ontology (GO) - Molecular Function for ADRB1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004930 G-protein coupled receptor activity --
GO:0004939 beta-adrenergic receptor activity TAS 8892658
GO:0004940 beta1-adrenergic receptor activity IEA --
GO:0005057 receptor signaling protein activity IDA 12391161
GO:0005088 Ras guanyl-nucleotide exchange factor activity IDA 12391161
genes like me logo Genes that share ontologies with ADRB1: view
genes like me logo Genes that share phenotypes with ADRB1: view

Animal Models for ADRB1 Gene

MGI Knock Outs for ADRB1:

Animal Model Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for ADRB1

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Transcription Factor Targets and HOMER Transcription for ADRB1 Gene

Localization for ADRB1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ADRB1 Gene

Cell membrane; Multi-pass membrane protein. Early endosome. Note=Colocalizes with RAPGEF2 at the plasma membrane (By similarity). Localized at the plasma membrane. Found in the Golgi upon GOPC overexpression. {ECO:0000250}.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for ADRB1 Gene COMPARTMENTS Subcellular localization image for ADRB1 gene
Compartment Confidence
endosome 5
plasma membrane 5
endoplasmic reticulum 2
cytoskeleton 1
cytosol 1
extracellular 1
nucleus 1

Gene Ontology (GO) - Cellular Components for ADRB1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005769 early endosome IDA 21540189
GO:0005886 plasma membrane TAS --
GO:0005887 integral component of plasma membrane TAS 10212248
GO:0016020 membrane --
GO:0016021 integral component of membrane --
genes like me logo Genes that share ontologies with ADRB1: view

Pathways & Interactions for ADRB1 Gene

genes like me logo Genes that share pathways with ADRB1: view

PCR Array Products

SIGNOR curated interactions for ADRB1 Gene

Is inactivated by:

Gene Ontology (GO) - Biological Process for ADRB1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001659 temperature homeostasis IBA --
GO:0001996 positive regulation of heart rate by epinephrine-norepinephrine IBA --
GO:0001997 positive regulation of the force of heart contraction by epinephrine-norepinephrine IEA --
GO:0002024 diet induced thermogenesis IEA --
GO:0002025 vasodilation by norepinephrine-epinephrine involved in regulation of systemic arterial blood pressure IBA --
genes like me logo Genes that share ontologies with ADRB1: view

Drugs & Compounds for ADRB1 Gene

(114) Drugs for ADRB1 Gene - From: NovoSeek, IUPHAR, DGIdb, ClinicalTrials, HMDB, DrugBank, PharmGKB, and ApexBio

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Metoprolol Approved, Investigational Pharma Antagonist, antagonist, Target 186
Atenolol Approved Pharma Antagonist, antagonist, Target 98
Dobutamine Approved Pharma Partial agonist, Agonist, agonist, Target 99
Isoproterenol Approved Pharma Full agonist, Agonist, agonist, Target 15
Bisoprolol Approved Pharma antagonist, Target 57

(22) Additional Compounds for ADRB1 Gene - From: NovoSeek, Tocris, IUPHAR, and HMDB

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
(plusmn)-adrenaline
Full agonist, Agonist
8-Hydroxycarvedilol
(RS)-Atenolol
29122-68-7
(S)-(-)-Atenolol
93379-54-5
(S)-Timolol maleate
26921-17-5
genes like me logo Genes that share compounds with ADRB1: view

Drug Products

Transcripts for ADRB1 Gene

mRNA/cDNA for ADRB1 Gene

(1) REFSEQ mRNAs :
(3) Additional mRNA sequences :
(38) Selected AceView cDNA sequences:
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for ADRB1 Gene

Adrenoceptor beta 1:
Representative Sequences:

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for ADRB1

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for ADRB1 Gene

No ASD Table

Relevant External Links for ADRB1 Gene

GeneLoc Exon Structure for
ADRB1
ECgene alternative splicing isoforms for
ADRB1

Expression for ADRB1 Gene

mRNA expression in normal human tissues for ADRB1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for ADRB1 Gene

This gene is overexpressed in Heart - Left Ventricle (x9.1) and Heart - Atrial Appendage (x5.4).

Protein differential expression in normal tissues from HIPED for ADRB1 Gene

This gene is overexpressed in Plasma (69.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for ADRB1 Gene



SOURCE GeneReport for Unigene cluster for ADRB1 Gene Hs.99913

genes like me logo Genes that share expression patterns with ADRB1: view

Protein tissue co-expression partners for ADRB1 Gene

Primer Products

In Situ Assay Products

No data available for mRNA Expression by UniProt/SwissProt for ADRB1 Gene

Orthologs for ADRB1 Gene

This gene was present in the common ancestor of animals.

Orthologs for ADRB1 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia ADRB1 35
  • 89.66 (n)
  • 85.78 (a)
ADRB1 36
  • 87 (a)
OneToOne
dog
(Canis familiaris)
Mammalia ADRB1 35
  • 89.36 (n)
  • 85.41 (a)
ADRB1 36
  • 88 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Adrb1 35
  • 88.82 (n)
  • 90.32 (a)
Adrb1 16
Adrb1 36
  • 93 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia ADRB1 35
  • 96.29 (n)
  • 94.54 (a)
ADRB1 36
  • 99 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Adrb1 35
  • 88.75 (n)
  • 90.54 (a)
oppossum
(Monodelphis domestica)
Mammalia ADRB1 36
  • 65 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia ADRB1 36
  • 79 (a)
OneToOne
chicken
(Gallus gallus)
Aves ADRB1 35
  • 75.32 (n)
  • 70.23 (a)
ADRB1 36
  • 68 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia ADRB1 36
  • 63 (a)
OneToOne
African clawed frog
(Xenopus laevis)
Amphibia Xl.14992 35
zebrafish
(Danio rerio)
Actinopterygii adrb1 35
  • 66.03 (n)
  • 64.66 (a)
adrb1 36
  • 62 (a)
OneToMany
adrb1 36
  • 62 (a)
OneToMany
fruit fly
(Drosophila melanogaster)
Insecta CG6919 37
  • 36 (a)
DopR2 37
  • 45 (a)
DopR2 35
  • 56.98 (n)
  • 45.26 (a)
oa2 36
  • 26 (a)
ManyToMany
Octbeta2R 36
  • 25 (a)
ManyToMany
African malaria mosquito
(Anopheles gambiae)
Insecta GPRDOP2 35
  • 48.47 (n)
  • 46.52 (a)
worm
(Caenorhabditis elegans)
Secernentea M03F4.3 37
  • 39 (a)
Species with no ortholog for ADRB1:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)

Evolution for ADRB1 Gene

ENSEMBL:
Gene Tree for ADRB1 (if available)
TreeFam:
Gene Tree for ADRB1 (if available)

Paralogs for ADRB1 Gene

Paralogs for ADRB1 Gene

(20) SIMAP similar genes for ADRB1 Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with ADRB1: view

Variants for ADRB1 Gene

Sequence variations from dbSNP and Humsavar for ADRB1 Gene

SNP ID Clin Chr 10 pos Sequence Context AA Info Type MAF
rs171169 -- 114,045,621(-) ACACA(A/G)ATCTC utr-variant-3-prime
rs171170 -- 114,045,331(-) GGCGC(A/C)GGCGG reference, missense
rs180897 -- 114,045,159(-) GTTGG(C/T)CAGGA missense, reference
rs189429 -- 114,045,188(+) ACCAG(A/C)TCGCG synonymous-codon, missense, reference
rs238739 -- 114,045,630(-) CTTAA(G/T)TAAAC utr-variant-3-prime

Structural Variations from Database of Genomic Variants (DGV) for ADRB1 Gene

Variant ID Type Subtype PubMed ID
nsv7211 OTHER Inversion 18451855
nsv896017 CNV Loss 21882294
dgv823n71 CNV Loss 21882294
nsv896021 CNV Loss 21882294
dgv824n71 CNV Loss 21882294
nsv896025 CNV Loss 21882294
dgv825n71 CNV Loss 21882294

Variation tolerance for ADRB1 Gene

Residual Variation Intolerance Score: 34.11% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.10; 38.37% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for ADRB1 Gene

HapMap Linkage Disequilibrium report
ADRB1
Human Gene Mutation Database (HGMD)
ADRB1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ADRB1 Gene

Disorders for ADRB1 Gene

MalaCards: The human disease database

(19) MalaCards diseases for ADRB1 Gene - From: DISEASES, NovoSeek, and GeneCards

Disorder Aliases PubMed IDs
ocular hypotension
  • hypotony of eye, unspecified
coronary artery disease
  • chronic myocardial ischemia
orthostatic intolerance
  • neurocirculatory asthenia
congestive heart failure
  • chf
meningococcal infection
  • meningococcal infections
- elite association
Search ADRB1 in MalaCards View complete list of genes associated with diseases

Relevant External Links for ADRB1

Genetic Association Database (GAD)
ADRB1
Human Genome Epidemiology (HuGE) Navigator
ADRB1
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
ADRB1
genes like me logo Genes that share disorders with ADRB1: view

No data available for UniProtKB/Swiss-Prot and Genatlas for ADRB1 Gene

Publications for ADRB1 Gene

  1. Beta-arrestin2 enhances beta2-adrenergic receptor-mediated nuclear translocation of ERK. (PMID: 16038799) Kobayashi H. … Kurose H. (Cell. Signal. 2005) 23 25 26 67
  2. The Arg389Gly beta1-adrenoceptor polymorphism and catecholamine effects on plasma-renin activity. (PMID: 16325050) Bruck H. … Brodde O.E. (J. Am. Coll. Cardiol. 2005) 23 25 26 67
  3. Loss of beta-adrenoceptor response in myocytes overexpressing the Na+/Ca(2+)-exchanger. (PMID: 14734046) Sato M. … Harding S.E. (J. Mol. Cell. Cardiol. 2004) 23 25 26 67
  4. Dose-effect and pharmacokinetic-pharmacodynamic relationships of the beta 1-adrenergic receptor blocking properties of various doses of carvedilol in healthy humans. (PMID: 7908256) de Mey C. … Belz G.G. (Clin. Pharmacol. Ther. 1994) 23 25 26 67
  5. Interethnic differences in drug response: the contribution of genetic variability in beta adrenergic receptor and cytochrome P4502C9. (PMID: 17329986) Muszkat M. (Clin. Pharmacol. Ther. 2007) 25 26 67

Products for ADRB1 Gene

Sources for ADRB1 Gene

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