Aliases for ADRB1 Gene
External Ids for ADRB1 Gene
Previous Symbols for ADRB1 Gene
The adrenergic receptors (subtypes alpha 1, alpha 2, beta 1, and beta 2) are a prototypic family of guanine nucleotide binding regulatory protein-coupled receptors that mediate the physiological effects of the hormone epinephrine and the neurotransmitter norepinephrine. Specific polymorphisms in this gene have been shown to affect the resting heart rate and can be involved in heart failure. [provided by RefSeq, Jul 2008]
GeneCards Summary for ADRB1 Gene
ADRB1 (Adrenoceptor Beta 1) is a Protein Coding gene. Diseases associated with ADRB1 include aortic coarctation and chagas disease. Among its related pathways are Signaling by GPCR and Activation of cAMP-Dependent PKA. GO annotations related to this gene include protein heterodimerization activity and drug binding. An important paralog of this gene is TAAR9.
UniProtKB/Swiss-Prot for ADRB1 Gene
Beta-adrenergic receptors mediate the catecholamine-induced activation of adenylate cyclase through the action of G proteins. This receptor binds epinephrine and norepinephrine with approximately equal affinity. Mediates Ras activation through G(s)-alpha- and cAMP-mediated signaling.
The adrenergic beta1 receptor (beta1-adrenoceptor) is a member of the adrenergic receptor group of G-protein-coupled receptors that also includes alpha1A, alpha1B, alpha1D, alpha2A, alpha2B, alpha2C, beta2 and beta3. They are located primarily in the CNS, heart, coronary artery, kidney and muscle and are involved in cardiac stimulation, coronary vasodilation and relaxation of the colon and esophagus. The human adrenergic beta1 receptor gene has been localized to chromosome 10 (10q24-q26).