Aliases for ADRB1 Gene
External Ids for ADRB1 Gene
Previous HGNC Symbols for ADRB1 Gene
Previous GeneCards Identifiers for ADRB1 Gene
The adrenergic receptors (subtypes alpha 1, alpha 2, beta 1, and beta 2) are a prototypic family of guanine nucleotide binding regulatory protein-coupled receptors that mediate the physiological effects of the hormone epinephrine and the neurotransmitter norepinephrine. Specific polymorphisms in this gene have been shown to affect the resting heart rate and can be involved in heart failure. [provided by RefSeq, Jul 2008]
GeneCards Summary for ADRB1 Gene
ADRB1 (Adrenoceptor Beta 1) is a Protein Coding gene. Diseases associated with ADRB1 include Resting Heart Rate, Variation In and Coronary Artery Anomaly. Among its related pathways are Monoamine GPCRs and Peptide ligand-binding receptors. Gene Ontology (GO) annotations related to this gene include G-protein coupled receptor activity and PDZ domain binding. An important paralog of this gene is ADRB2.
UniProtKB/Swiss-Prot for ADRB1 Gene
Beta-adrenergic receptors mediate the catecholamine-induced activation of adenylate cyclase through the action of G proteins. This receptor binds epinephrine and norepinephrine with approximately equal affinity. Mediates Ras activation through G(s)-alpha- and cAMP-mediated signaling.
The adrenergic beta1 receptor (beta1-adrenoceptor) is a member of the adrenergic receptor group of G-protein-coupled receptors that also includes alpha1A, alpha1B, alpha1D, alpha2A, alpha2B, alpha2C, beta2 and beta3. They are located primarily in the CNS, heart, coronary artery, kidney and muscle.