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Aliases for ADRA2C Gene

Aliases for ADRA2C Gene

  • Adrenoceptor Alpha 2C 2 3 5
  • Alpha-2 Adrenergic Receptor Subtype C4 3 4
  • Adrenergic, Alpha-2C-, Receptor 2 3
  • Alpha-2C Adrenoreceptor 3 4
  • Alpha-2C Adrenoceptor 3 4
  • Alpha-2CAR 3 4
  • ADRA2RL2 3 4
  • ADRA2L2 3 4
  • Alpha-2C-Adrenergic Receptor 3
  • Alpha2-AR-C4 3
  • ADRARL2 3

External Ids for ADRA2C Gene

Previous HGNC Symbols for ADRA2C Gene

  • ADRA2L2
  • ADRA2RL2

Previous GeneCards Identifiers for ADRA2C Gene

  • GC04U990002
  • GC04M9J0040
  • GC04P003798

Summaries for ADRA2C Gene

Entrez Gene Summary for ADRA2C Gene

  • Alpha-2-adrenergic receptors are members of the G protein-coupled receptor superfamily. They include 3 highly homologous subtypes: alpha2A, alpha2B, and alpha2C. These receptors have a critical role in regulating neurotransmitter release from sympathetic nerves and from adrenergic neurons in the central nervous system. The mouse studies revealed that both the alpha2A and alpha2C subtypes were required for normal presynaptic control of transmitter release from sympathetic nerves in the heart and from central noradrenergic neurons. The alpha2A subtype inhibited transmitter release at high stimulation frequencies, whereas the alpha2C subtype modulated neurotransmission at lower levels of nerve activity. This gene encodes the alpha2C subtype, which contains no introns in either its coding or untranslated sequences. [provided by RefSeq, Jul 2008]

GeneCards Summary for ADRA2C Gene

ADRA2C (Adrenoceptor Alpha 2C) is a Protein Coding gene. Diseases associated with ADRA2C include Raynaud Disease and Orthostatic Intolerance. Among its related pathways are Peptide ligand-binding receptors and Signaling by GPCR. GO annotations related to this gene include G-protein coupled receptor activity and protein heterodimerization activity. An important paralog of this gene is HTR1F.

UniProtKB/Swiss-Prot for ADRA2C Gene

  • Alpha-2 adrenergic receptors mediate the catecholamine-induced inhibition of adenylate cyclase through the action of G proteins.

Tocris Summary for ADRA2C Gene

  • Adrenergic alpha2 receptors (alpha2-adrenoceptors) are members of the adrenergic receptor group of G-protein-coupled receptors that also includes alpha1A, alpha1B, alpha1D, beta1, beta2 and beta3. Adrenergic alpha2 receptors are divided into three subtypes in humans: alpha2A, alpha2B and alpha2C.

Gene Wiki entry for ADRA2C Gene

No data available for PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ADRA2C Gene

Genomics for ADRA2C Gene

Regulatory Elements for ADRA2C Gene

Enhancers for ADRA2C Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around ADRA2C on UCSC Golden Path with GeneCards custom track

Promoters for ADRA2C Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around ADRA2C on UCSC Golden Path with GeneCards custom track

Genomic Location for ADRA2C Gene

3,766,348 bp from pter
3,768,526 bp from pter
2,179 bases
Plus strand

Genomic View for ADRA2C Gene

Genes around ADRA2C on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ADRA2C Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ADRA2C Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ADRA2C Gene

Proteins for ADRA2C Gene

  • Protein details for ADRA2C Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Alpha-2C adrenergic receptor
    Protein Accession:
    Secondary Accessions:
    • P35369
    • Q9HB49

    Protein attributes for ADRA2C Gene

    462 amino acids
    Molecular mass:
    49522 Da
    Quaternary structure:
    No Data Available
    • Sequence=AAA35513.1; Type=Frameshift; Positions=270, 296, 300; Evidence={ECO:0000305}; Sequence=AAC78723.1; Type=Frameshift; Positions=270, 296, 300; Evidence={ECO:0000305};

neXtProt entry for ADRA2C Gene

Proteomics data for ADRA2C Gene at MOPED

Post-translational modifications for ADRA2C Gene

  • Glycosylation at Asn 19 and Asn 33
  • Modification sites at PhosphoSitePlus

Other Protein References for ADRA2C Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for ADRA2C Gene

Domains & Families for ADRA2C Gene

Gene Families for ADRA2C Gene

Suggested Antigen Peptide Sequences for ADRA2C Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the G-protein coupled receptor 1 family. Adrenergic receptor subfamily. ADRA2C sub-subfamily.
  • Belongs to the G-protein coupled receptor 1 family. Adrenergic receptor subfamily. ADRA2C sub-subfamily.
genes like me logo Genes that share domains with ADRA2C: view

Function for ADRA2C Gene

Molecular function for ADRA2C Gene

GENATLAS Biochemistry:
adrenergic,alpha-2C-,receptor,G protein coupled receptor superfamily,without action on ion channels
UniProtKB/Swiss-Prot Function:
Alpha-2 adrenergic receptors mediate the catecholamine-induced inhibition of adenylate cyclase through the action of G proteins.
genes like me logo Genes that share phenotypes with ADRA2C: view

Animal Models for ADRA2C Gene

MGI Knock Outs for ADRA2C:

Animal Model Products

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , miRNA , Transcription Factor Targets and HOMER Transcription for ADRA2C Gene

Localization for ADRA2C Gene

Subcellular locations from UniProtKB/Swiss-Prot for ADRA2C Gene

Cell membrane; Multi-pass membrane protein.

Subcellular locations from

Jensen Localization Image for ADRA2C Gene COMPARTMENTS Subcellular localization image for ADRA2C gene
Compartment Confidence
plasma membrane 5
endosome 4
nucleus 1

Gene Ontology (GO) - Cellular Components for ADRA2C Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005886 plasma membrane TAS --
genes like me logo Genes that share ontologies with ADRA2C: view

Pathways & Interactions for ADRA2C Gene

genes like me logo Genes that share pathways with ADRA2C: view

Gene Ontology (GO) - Biological Process for ADRA2C Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006940 regulation of smooth muscle contraction IEA --
GO:0030168 platelet activation IEA,TAS --
GO:0044281 small molecule metabolic process TAS --
GO:0045666 positive regulation of neuron differentiation IDA 17215105
GO:0070473 negative regulation of uterine smooth muscle contraction IEA --
genes like me logo Genes that share ontologies with ADRA2C: view

No data available for SIGNOR curated interactions for ADRA2C Gene

Drugs & Compounds for ADRA2C Gene

(133) Drugs for ADRA2C Gene - From: DrugBank, PharmGKB, ApexBio, DGIdb, IUPHAR, HMDB, Tocris, and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Yohimbine Approved Pharma Antagonist, antagonist, Target 25
Clonidine Approved Pharma Partial agonist, Agonist, agonist, Target 217
Apomorphine Approved, Investigational Pharma Partial agonist, Agonist, agonist, Target 34
Brimonidine Approved Pharma Full agonist, Agonist, agonist, Target 0
Bromocriptine Approved, Investigational Pharma Antagonist, agonist, Target 29

(6) Additional Compounds for ADRA2C Gene - From: IUPHAR, Tocris, and Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
Partial agonist, Agonist
Clonidine hydrochloride
Guanfacine hydrochloride
Rilmenidine hemifumarate
UK 14,304

(5) Tocris Compounds for ADRA2C Gene

Compound Action Cas Number
Clonidine hydrochloride alpha2 agonist. Also I1 ligand 4205-91-8
Guanabenz acetate alpha2 agonist. Also I2 selective ligand 23256-50-0
Guanfacine hydrochloride alpha2A agonist 29110-48-3
Rilmenidine hemifumarate alpha2 agonist. Also I1 ligand 207572-68-7
UK 14,304 alpha2 agonist 59803-98-4

(54) ApexBio Compounds for ADRA2C Gene

Compound Action Cas Number
Acebutolol HCl 34381-68-5
Adrenalone HCl 62-13-5
Alfuzosin HCl α1 adrenoceptor antagonist,functionally uro-selective 81403-68-1
Bambuterol 81732-65-2
Betaxolol βadrenergic receptor blocker 659-18-7
Betaxolol HCl 63659-19-8
Bisoprolol fumarate 104344-23-2
Carvedilol 72956-09-3
Cisatracurium Besylate Neuromuscular-blocking drug 96946-42-8
Clonidine HCl 4205-91-8
Detomidine HCl 90038-01-0
Dexmedetomidine 113775-47-6
Dexmedetomidine HCl 145108-58-3
DL-Adrenaline 329-65-7
Doxazosin Mesylate α1-adrenergic receptor antagonist 77883-43-3
Epinephrine Bitartrate 51-42-3
Epinephrine HCl 55-31-2
Formoterol Hemifumarate 43229-80-7
Guanabenz Acetate 23256-50-0
Indacaterol Maleate 753498-25-8
Isoprenaline HCl 51-30-9
Ivabradine HCl 148849-67-6
Labetalol HCl 32780-64-6
L-Adrenaline 51-43-4
Lurasidone HCl Dopamine D2/5-HT2A/5-HT7/5-HT1A inhibitor 367514-88-3
Maprotiline HCl 10347-81-6
Medetomidine HCl 86347-15-1
Methyldopa 555-30-6
Metoprolol Tartrate β1-adrenergic blocking agent 392-17-7
Mirabegron (YM178) 223673-61-8
Naftopidil α1-adrenergic receptor antagonist 57149-07-2
Naftopidil DiHCl 57149-08-3
Naphazoline HCl 550-99-2
Nebivolol 152520-56-4
Nedaplatin 95734-82-0
Oxymetazoline HCl Alpha-1/alpha-2 agonist 2315-02-8
Phenoxybenzamine HCl 63-92-3
Phentolamine Mesylate Alpha 1/2-blocking agent 65-28-1
Phenylephrine HCl 61-76-7
Prazosin HCl α1 and α2B-adrenoceptor antagonist 19237-84-4
Propranolol HCl 318-98-9
Ritodrine HCl β-2 adrenergic receptor agonist 23239-51-2
Salbutamol Sulfate β-2 adrenergic receptor agonist 51022-70-9
Salmeterol xinafoate β2-adrenergic receptor agonist 94749-08-3
Scopine 498-45-3
Silodosin α1-adrenoceptor antagonist 160970-54-7
Synephrine HCl 5985-28-4
Terazosin HCl 70024-40-7
Terbutaline Sulfate 23031-32-5
Tetrahydrozoline HCl 522-48-5
Timolol Maleate 26921-17-5
Tizanidine HCl 64461-82-1
Tolazoline HCl 59-97-2
Xylazine HCl α2 Adrenoceptor agonist 23076-35-9
genes like me logo Genes that share compounds with ADRA2C: view

Transcripts for ADRA2C Gene

mRNA/cDNA for ADRA2C Gene

(1) REFSEQ mRNAs :
(2) Additional mRNA sequences :
(29) Selected AceView cDNA sequences:
(2) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for ADRA2C Gene

Adrenoceptor alpha 2C:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for ADRA2C Gene

No ASD Table

Relevant External Links for ADRA2C Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for ADRA2C Gene

mRNA expression in normal human tissues for ADRA2C Gene

mRNA differential expression in normal tissues according to GTEx for ADRA2C Gene

This gene is overexpressed in Artery - Aorta (x8.2), Cervix - Endocervix (x6.7), and Artery - Tibial (x4.8).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for ADRA2C Gene

SOURCE GeneReport for Unigene cluster for ADRA2C Gene Hs.123022

genes like me logo Genes that share expression patterns with ADRA2C: view

Primer Products

No data available for Protein differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Protein tissue co-expression partners for ADRA2C Gene

Orthologs for ADRA2C Gene

This gene was present in the common ancestor of animals.

Orthologs for ADRA2C Gene

Organism Taxonomy Gene Similarity Type Details
(Canis familiaris)
Mammalia ADRA2C 35
  • 89.71 (n)
  • 89.03 (a)
  • 90 (a)
(Mus musculus)
Mammalia Adra2c 35
  • 84.3 (n)
  • 89.06 (a)
Adra2c 16
Adra2c 36
  • 94 (a)
(Pan troglodytes)
Mammalia ADRA2C 35
  • 98.62 (n)
  • 98.71 (a)
  • 88 (a)
(Rattus norvegicus)
Mammalia Adra2c 35
  • 84.6 (n)
  • 88.62 (a)
(Monodelphis domestica)
Mammalia ADRA2C 36
  • 67 (a)
(Gallus gallus)
Aves ADRA2C 35
  • 72.07 (n)
  • 74.68 (a)
  • 69 (a)
(Anolis carolinensis)
Reptilia -- 36
  • 45 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia adra2c 35
  • 68.64 (n)
  • 72.04 (a)
African clawed frog
(Xenopus laevis)
Amphibia Xl.26396 35
(Danio rerio)
Actinopterygii -- 35
adra2c 35
  • 64.38 (n)
  • 68.07 (a)
adra2c 36
  • 63 (a)
fruit fly
(Drosophila melanogaster)
Insecta 5-HT7 37
  • 33 (a)
CG18208 37
  • 49 (a)
DopR2 37
  • 44 (a)
CG18208 36
  • 23 (a)
Oct-TyrR 36
  • 24 (a)
(Caenorhabditis elegans)
Secernentea sca-1 37
  • 31 (a)
ser-1 37
  • 31 (a)
octr-1 36
  • 30 (a)
ser-2 36
  • 30 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 28 (a)
Species with no ortholog for ADRA2C:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • cow (Bos Taurus)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for ADRA2C Gene

Gene Tree for ADRA2C (if available)
Gene Tree for ADRA2C (if available)

Paralogs for ADRA2C Gene

(18) SIMAP similar genes for ADRA2C Gene using alignment to 3 proteins:

genes like me logo Genes that share paralogs with ADRA2C: view

Variants for ADRA2C Gene

Polymorphic Variants from UniProtKB/Swiss-Prot for ADRA2C Gene

The Del322-325 variant has a significant loss of function. It is approximately 10 times more frequent in African-Americans compared with Caucasians (allele frequencies 0.381 versus 0.040).

Sequence variations from dbSNP and Humsavar for ADRA2C Gene

SNP ID Clin Chr 04 pos Sequence Context AA Info Type
rs1133450 -- 3,767,808(+) CTTCA(G/T)CTACA reference, missense
rs1133452 -- 3,767,943(+) CCGGC(C/G)ATCCT reference, missense
rs1133453 -- 3,767,950(+) TCCTT(C/T)AAGCA reference, synonymous-codon
rs1800037 -- 3,767,719(+) CGCAA(C/G)GTGGC reference, missense
rs6816971 -- 3,765,620(+) GGGGA(A/G)GCGAA upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for ADRA2C Gene

Variant ID Type Subtype PubMed ID
dgv1566e1 CNV Complex 17122850
nsv878471 CNV Loss 21882294
dgv5438n71 CNV Loss 21882294
dgv5440n71 CNV Loss 21882294
dgv5441n71 CNV Loss 21882294
nsv519631 CNV Loss 19592680
nsv878509 CNV Loss 21882294
dgv854n67 CNV Gain 20364138
esv26274 CNV Loss 19812545

Variation tolerance for ADRA2C Gene

Residual Variation Intolerance Score: 34.2% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 8.58; 86.14% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for ADRA2C Gene

Human Gene Mutation Database (HGMD)

Disorders for ADRA2C Gene

MalaCards: The human disease database

(3) MalaCards diseases for ADRA2C Gene - From: DISEASES, Novoseek, and GeneCards

Disorder Aliases PubMed IDs
raynaud disease
  • raynaud's disease
orthostatic intolerance
  • neurocirculatory asthenia
attention deficit-hyperactivity disorder
  • attention deficit hyperactivity disorder
- elite association - COSMIC cancer census association via MalaCards

Relevant External Links for ADRA2C

Genetic Association Database (GAD)
Human Genome Epidemiology (HuGE) Navigator
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
genes like me logo Genes that share disorders with ADRA2C: view

No data available for UniProtKB/Swiss-Prot and Genatlas for ADRA2C Gene

Publications for ADRA2C Gene

  1. Identification of an additional gene belonging to the alpha 2 adrenergic receptor family in the human genome by PCR. (PMID: 1849485) Chhajlani V. … Wikberg J.E.S. (FEBS Lett. 1991) 2 3 4 23 67
  2. Alpha2C-adrenergic receptors exhibit enhanced surface expression and signaling upon association with beta2-adrenergic receptors. (PMID: 16757535) Prinster S.C. … Hall R.A. (J. Pharmacol. Exp. Ther. 2006) 23 25 26
  3. An alpha2C-adrenergic receptor polymorphism alters the norepinephrine-lowering effects and therapeutic response of the beta-blocker bucindolol in chronic heart failure. (PMID: 19880803) Bristow M.R. … Liggett S.B. (Circ Heart Fail 2010) 3 23
  4. Alpha-adrenoceptor agonistic activity of oxymetazoline and xylometazoline. (PMID: 20030735) Haenisch B. … BAPnisch H. (Fundam Clin Pharmacol 2010) 25 26
  5. The dopamine receptor D2 agonist bromocriptine inhibits glucose-stimulated insulin secretion by direct activation of the alpha2-adrenergic receptors in beta cells. (PMID: 20138024) de Leeuw van Weenen J.E. … Guigas B. (Biochem. Pharmacol. 2010) 25 26

Products for ADRA2C Gene

Sources for ADRA2C Gene