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Category Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21

GIFtS
-

ADRA2C Gene

protein-coding GIFtS: 67
GCID: GC04P003804

adrenoceptor alpha 2C

(Previous names: adrenergic, alpha-2C-, receptor )
(Previous symbols: ADRA2L2, ADRA2RL2)

Explore 30 diseases affiliated with
ADRA2C via

MalaCards

our new
Human Malady Compendium

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc, ⁷Ensembl, ⁸DME, ⁹miRBase, and/or ¹⁰fRNAdb)
About This Section

Aliases
Adrenoceptor Alpha 2C¹ ²		Alpha-2C Adrenoreceptor² ³
ADRA2L2¹ ² ³ ⁵		ALPHA2CAR²
ADRA2RL2¹ ² ³		Alpha-2CAR³
ADRARL2¹ ²		Alpha-2C Adrenergic Receptor²
Adrenergic, Alpha-2C-, Receptor¹ ²		Alpha-2C-Adrenergic Receptor²
Alpha-2 Adrenergic Receptor Subtype C4² ³		Alpha2-AR-C4¹
Alpha-2C Adrenoceptor² ³		Alpha-2CAR³

External Ids:	HGNC: 283¹	Entrez Gene: 152²	Ensembl: ENSG00000184160⁷	OMIM: 104250⁵	UniProtKB: P18825³

Export aliases for ADRA2C gene to outside databases

Previous GC identifers: GC04U990002 GC04M9J0040 GC04P003798

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for ADRA2C:

Alpha-2-adrenergic receptors are members of the G protein-coupled receptor superfamily. They include 3 highly

homologous subtypes: alpha2A, alpha2B, and alpha2C. These receptors have a critical role in regulating

neurotransmitter release from sympathetic nerves and from adrenergic neurons in the central nervous system. The mouse

studies revealed that both the alpha2A and alpha2C subtypes were required for normal presynaptic control of

transmitter release from sympathetic nerves in the heart and from central noradrenergic neurons. The alpha2A subtype

inhibited transmitter release at high stimulation frequencies, whereas the alpha2C subtype modulated neurotransmission

at lower levels of nerve activity. This gene encodes the alpha2C subtype, which contains no introns in either its

coding or untranslated sequences. (provided by RefSeq, Jul 2008)

UniProtKB/Swiss-Prot: ADA2C_HUMAN, P18825

Function: Alpha-2 adrenergic receptors mediate the catecholamine-induced inhibition of adenylate cyclase through the

action of G proteins

summary for ADRA2C:

Adrenergic alpha2 receptors (alpha2-adrenoceptors) are members of the adrenergic receptor group of

G-protein-coupled receptors that also includes alpha1A, alpha1B, alpha1D, beta1, beta2 and beta3. Adrenergic

alpha2 receptors are divided into three subtypes: alpha2A, alpha2B and alpha2C, which are widely distributed

in both the CNS and periphery. Alpha2-adrenoceptors play a role in the modulation of neurotransmission,

smooth muscle contraction and thermoregulation. A fourth pharmacological subtype, alpha2D, has been

identified in the rat which is thought to be a species ortholog of the human alpha2A subtype.

Gene Wiki entry for ADRA2C (Alpha-2C adrenergic receptor)

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section

RefSeq DNA sequence:

NC_000004.11 NC_018915.1 NT_006051.18

Regulatory elements:

SABiosciences Regulatory transcription factor binding sites in the ADRA2C gene promoter:
Bach1 E2F-3a E2F-4 E2F-5 STAT1beta E2F-2 MEF-2A E2F-1 E2F aMEF-2
Other transcription factors

Browse SwitchGear Promoter luciferase reporter plasmids

Search SABiosciences Chromatin IP Primers for ADRA2C

Epigenetics:

QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat ADRA2C

Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 4p16 Ensembl cytogenetic band: 4p16.3 HGNC cytogenetic band: 4p16.3

ADRA2C Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
ADRA2C gene location

GeneLoc information about chromosome 4 GeneLoc Exon Structure

GeneLoc location for GC04P003804: view genomic region (about GC identifiers)

Start:	3,768,075 bp from pter	End:	3,770,253 bp from pter
Size:	2,179 bases	Orientation:	plus strand

(According to ¹UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to ²PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section

UniProtKB/Swiss-Prot: ADA2C_HUMAN, P18825 (See protein sequence)

Recommended Name: Alpha-2C adrenergic receptor

Size: 462 amino acids; 49522 Da

Subcellular location: Cell membrane; Multi-pass membrane protein

Sequence caution: Sequence=AAA35513.1; Type=Frameshift; Positions=270, 296, 300; Sequence=AAC78723.1; Type=Frameshift;

Positions=270, 296, 300;

Secondary accessions: P35369 Q9HB49

Explore the universe of human proteins at neXtProt for ADRA2C: NX_P18825

Post-translational modifications:

View modification sites using PhosphoSitePlus²

View neXtProt modification sites for NX_P18825

ADRA2C Protein expression data from MOPED and PaxDb: About this image

REFSEQ proteins: NP_000674.2

ENSEMBL proteins:

ENSP00000426268 ENSP00000386069

Reactome Protein details: P18825
Human Recombinant Protein Products for ADRA2C:

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	Browse Proteins at Uscn

Gene Ontology (GO): 5/7 cellular component terms (GO ID links to tree view) (see all 7): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005737	cytoplasm	IDA	16605244
GO:0005768	endosome	TAS	10196213
GO:0005886	plasma membrane	TAS	--
GO:0005887	integral to plasma membrane	IDA	16605244
GO:0016021	integral to membrane	--	--

ADRA2C for ontologies About GeneDecksing

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(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

ADRA2C for domains About GeneDecksing

4 InterPro domains/families:

IPR017452 GPCR_Rhodpsn_7TM

IPR002233 Adrnrgc_rcpt

IPR000735 Adren_rcpt_A2C

IPR000276 GPCR_Rhodpsn

Graphical View of Domain Structure for InterPro Entry P18825

ProtoNet protein and cluster: P18825

2 Blocks protein families:

IPB000735 Alpha-2C adrenergic receptor signature

IPB002233 Adrenergic receptor signature

UniProtKB/Swiss-Prot: ADA2C_HUMAN, P18825

Similarity: Belongs to the G-protein coupled receptor 1 family. Adrenergic receptor subfamily. ADRA2C sub-subfamily

(According to ¹UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or ²DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory,
bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, Sirion Biotech, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, Sirion Biotech, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
About This Section

Molecular Function:

UniProtKB/Swiss-Prot Summary: ADA2C_HUMAN, P18825

Function: Alpha-2 adrenergic receptors mediate the catecholamine-induced inhibition of adenylate cyclase through the

action of G proteins

Genatlas biochemistry entry for ADRA2C:

adrenergic,alpha-2C-,receptor,G protein coupled receptor superfamily,without action on ion channels

Gene Ontology (GO): 5/7 molecular function terms (GO ID links to tree view) (see all 7): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0004930	G-protein coupled receptor activity	--	--
GO:0004938	alpha2-adrenergic receptor activity	IDA	17215105
GO:0005515	protein binding	IPI	16531006
GO:0031694	alpha-2A adrenergic receptor binding	IPI	16605244
GO:0042803	protein homodimerization activity	IDA	16605244

ADRA2C for ontologies About GeneDecksing

Phenotypes:
2 GenomeRNAi human phenotypes for ADRA2C:

Decreased substrate adherent c

Increased HPV18 LCR reporter a

6 MGI mutant phenotypes (inferred from 1 allele) (MGI details for Adra2c):

behavior/neurological	cardiovascular system	embryogenesis	homeostasis/metabolism	mortality/aging
nervous system

ADRA2C for phenotypes About GeneDecksing

Animal Models:
Mouse knock-out Adra2c^tm1Gsb for ADRA2C

inGenious Targeting Laboratory - Customizable classic, inducible, and humanized mouse model solutions for ADRA2C

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		hsa-miR-520d-5p hsa-miR-1271 hsa-miR-219-5p hsa-miR-182 hsa-miR-659 hsa-miR-376a* hsa-miR-129-3p hsa-miR-524-5p

		SwitchGear 3'UTR luciferase reporter plasmid: ADRA2C 3' UTR sequence

Inhib. RNA Products:		Browse for Gene Knock-down Tools from EMD Millipore
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In Situ Assay
Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ADRA2C

(Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to ¹UniProtKB, ²MINT, ³I2D, and/or ⁴STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
About This Section

Unified GeneCards pathways - 5/14 super-pathways (see all 14) About this table

See pathways by source

Super-pathway

contained gene-specific pathways

Class A/1 (Rhodopsin-like receptors)

Class A/1 (Rhodopsin-like receptors)	1.00	GPCRs, Class A Rhodopsin-like	0.41
GPCR ligand binding	0.75	Neuroactive ligand-receptor interaction	0.38
G alpha (i) signalling events	0.44

Activation of cAMP-Dependent PKA

	Activation of cAMP-Dependent PKA	1.00			Activation of PKA through GPCR	0.71
	cAMP Pathway	0.77

Signaling by GPCR

	Signaling by GPCR	1.00			Signal Transduction	0.56
	GPCR downstream signaling	0.89

Platelet activation, signaling and aggregation

Platelet activation, signaling and aggregation

1.00

Hemostasis

0.43

Adrenoceptors

Adrenoceptors

1.00

Adrenaline signalling through Alpha-2 adrenergic receptor

0.33

Pathway sources
See GeneCards unified pathways
Show all pathways

1 EMD Millipore Pathway for ADRA2C

Development Alpha-2 adrenergic receptor activation of ERK

4 Downloadable PowerPoint Slides of QIAGEN Pathway Central Maps for ADRA2C

	Activation of PKA through GPCR
	AMPK Enzyme Complex Pathway
	cAMP Pathway
	Activation of cAMP-Dependent PKA

1 GeneGo (Thomson Reuters) Pathway for ADRA2C

Development Alpha-2 adrenergic receptor activation of ERK

2 BioSystems Pathways for ADRA2C

	GPCRs, Class A Rhodopsin-like
	Monoamine GPCRs

5/17 Reactome Pathways for ADRA2C (see all 17)

	Metabolism
	Regulation of Insulin Secretion
	Adrenaline signalling through Alpha-2 adrenergic receptor
	G alpha (z) signalling events
	Signal Transduction

1 PharmGKB Pathway for ADRA2C

Sympathetic Nerve Pathway (Neuroeffector Junction)

1 Kegg Pathway (Kegg details for ADRA2C):

Neuroactive ligand-receptor interaction

ADRA2C for pathways About GeneDecksing

Interactions:

SABiosciences Gene Network Central^TM Interacting Genes and Proteins Network for ADRA2C

STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

5/150 Interacting proteins for ADRA2C (P18825³ ENSP00000386069⁴) via UniProtKB, MINT, STRING, and/or I2D (see all 150)

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
GNAO1	P09471³, ENSP00000262493⁴	I2D: score=1 STRING: ENSP00000262493
EIF2B1	Q14232³, ENSP00000228958⁴	I2D: score=3 STRING: ENSP00000228958
YWHAZ	P63104³, ENSP00000309503⁴	I2D: score=2 STRING: ENSP00000309503
PPP1R9B	Q96SB3³	I2D: score=2
ADCY2	ENSP00000342952⁴	STRING: ENSP00000342952

About this table

Gene Ontology (GO): 5/17 biological process terms (GO ID links to tree view) (see all 17): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0006112	energy reserve metabolic process	TAS	--
GO:0007186	G-protein coupled receptor signaling pathway	TAS	9371698
GO:0007267	cell-cell signaling	TAS	9371698
GO:0007565	female pregnancy	IEA	--
GO:0007596	blood coagulation	TAS	--

ADRA2C for ontologies About GeneDecksing

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
About This Section

ADRA2C for compounds About GeneDecksing

Browse Small Molecules at EMD Millipore

Browse drugs & compounds from Enzo Life Sciences

Compounds for ADRA2C available from Tocris Bioscience About this table

Compound	Action	CAS #
(R)-(+)-m-Nitrobiphenyline oxalate	Potent alpha2C agonist	--
JP 1302 dihydrochloride	Potent and selective alpha2C antagonist	[80259-18-3]
B-HT 933 dihydrochloride	Selective alpha2 agonist	[36067-72-8]
SKF 86466 hydrochloride	Potent and selective alpha2 antagonist	[86129-54-6]
Medetomidine hydrochloride	Potent, highly selective alpha2 agonist	[106807-72-1]

1 HMDB Compound for ADRA2C About this table

Compound	Synonyms	CAS #	PubMed Ids
Norepinephrine	(-)-(R)-Norepinephrine (see all 32)	51-41-2	--

10/28 DrugBank Compounds for ADRA2C (see all 28) About this table

Compound	Synonyms	CAS #	Type	Actions	PubMed Ids
Norepinephrine	Arterenol (see all 4)	51-41-2	target	agonist	1654268 18064417 17410123 1980236 17139284 8590979 17016423
Yohimbine	--	146-48-5	target	antagonist	12438517 10611634 16176444 11226402 12591093 12110610
Bethanidine	Betanidine (see all 2)	55-73-2	target	agonist	1962798 17139284 17016423 2545383
Brimonidine	Brimonidine tartrate (see all 2)	59803-98-4	target	agonist	11606316 16757535 12670699 14610637
Bromocriptine	Bromergocryptine (see all 10)	25614-03-3	target	agonist	10641988 18691132 20138024
Cabergoline	Cabergolina [Spanish] (see all 2)	81409-90-7	target	antagonist	10641988 18691132 12388667
Droxidopa	Droxydopa (see all 4)	23651-95-8	target	agonist	18680204 21173850 8590979
Ephedra	Chinese jointfir (see all 3)	--	target	agonist	12954796 14570629 15955613
Fenoldopam	Fenodopam mesylate (see all 3)	67227-57-0	target	antagonist	17139284 7670737 17016423
Methotrimeprazine	--	60-99-1	target	antagonist	2870716 6149771 15701205

6 Novoseek chemical compound relationships for ADRA2C gene About this table

Compound	-log (P-Val)	Hits	PubMed IDs for Articles with Shared Sentences (# sentences)
norepinephrine	59	6	15946904 (1), 18947427 (1), 10334470 (1), 16188498 (1) (see all 5)
yohimbine	54.9	2	16873606 (1), 15911252 (1)
forskolin	25.3	2	18487435 (1), 10999953 (1)
catecholamine	24.9	2	17075692 (1), 17643402 (1)
tyrosine	1.72	2	19037602 (1)
dopamine	0	2	10334470 (1)

Search CenterWatch for drugs/clinical trials and news about ADRA2C / ADA2C

(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from EMD Millipore,
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Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
About This Section

REFSEQ mRNAs for ADRA2C gene:

NM_000683.3

Unigene Cluster for ADRA2C:

Adrenoceptor alpha 2C

Hs.123022 [show with all ESTs]

Unigene Representative Sequence: BC142625

2 Ensembl transcripts including schematic representations, and UCSC links where relevant:

ENST00000509482 ENST00000330055(uc003ghm.3)

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		GenScript: all cDNA clones in your preferred vector: ADRA2C (NM_000683)
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		QIAGEN QuantiFast Probe-based Assays in human, mouse, rat ADRA2C

Additional cDNA sequence:

BC142625.1 J03853.1

2 DOTS entries:

DT.206046 DT.121235832

24/29 AceView cDNA sequences (see all 29):

CR590957 AW072770 AI492607 CD673805 AL549866 CB215653 BM987577 J03853

AI831889 T39448 AI539550 T40595 BU539106 BG830756 AL544609 AA458485

BU538114 NM_000683 AA936098 AL573897 AA010313 AL530417 CB217117 BU538113

GeneLoc Exon Structure

(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section

ADRA2C expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: GGCGTGTTCG

About this image

ADRA2C expression in embryonic tissues and stem cells
Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine About this table

Stem Cell Differentiation: 1 LifeMap Cell

Name

Category

Definitive endoderm-like cells (A scalable, suspensi...)

Expression:

Positive

Negative

Selective marker

Experimental details:

Curated

Microarrays

In-situ hybridization

See ADRA2C Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for ADRA2C

SOURCE GeneReport for Unigene cluster: Hs.123022

SABiosciences Expression via Pathway-Focused PCR Array including ADRA2C:

G Protein Coupled Receptors 384HT in human mouse rat

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In Situ
Assay Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ADRA2C

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD , ⁵MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or ⁶Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
About This Section

This gene was present in the common ancestor of animals.

Orthologs for ADRA2C gene from 5/16 species (see all 16) About this table

Organism	Taxonomic classification	Gene	Description	Human Similarity	Details
chicken (Gallus gallus)	Aves	ADRA2C¹	adrenergic, alpha-2C-, receptor	72.56(n) 76.41(a)	428799 XM_426355.3 XP_426355.3
African clawed frog (Xenopus laevis)	Amphibia	Xl.26396²	Xenopus laevis transcribed sequence with moderate similarity more	77.72(n)	CD361190.1
zebrafish (Danio rerio)	Actinopterygii	NM_194364.1²	--	81.15(n)	266754 NM_194364.1
fruit fly (Drosophila melanogaster)	Insecta	CG18208³	--	49(a) (best of 3)	--
worm (Caenorhabditis elegans)	Secernentea	sca-1³ ser-3¹	E1-E2 ATPases³ Protein SER-3¹	31(a) (best of 2)³ 40.9(n)¹ 34.3(a)¹	X(16610545-16618262)³ 259744¹ NM_059553.3¹ NP_491954.1¹

ENSEMBL Gene Tree for ADRA2C (if available)
TreeFam Gene Tree for ADRA2C (if available)

(Paralogs according to ¹HomoloGene,
²Ensembl, and ³SIMAP, Pseudogenes according to ⁴Pseudogene.org Build 68)
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Paralogs for ADRA2C gene

DRD4² HTR1A² ADRA1B² DRD2² HTR1F² HTR7² ADRA2A² HTR1D²

ADRA2B² ADRA1A² HTR1E² DRD3² HTR5A² HTR1B² ADRA1D²

18/19 SIMAP similar genes for ADRA2C using alignment to 3 protein entries: ADA2C_HUMAN (see all proteins) (see all similar genes):

ADORA2A ADRA2A ADRA2B HTR2A HTR2B HTR2C

ADRA1A GHSR ADRB2 DRD2 5HT1A HTR1A

DRD5P1 CCR5 GPR85 HTR1D HTR1F HRH3

ADRA2C for paralogs About GeneDecksing

(SNPs/Variants according to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
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UniProtKB/Swiss-Prot: ADA2C_HUMAN, P18825

Polymorphism: The Del322-325 variant has a significant loss of function. It is approximately 10 times more frequent in

African-Americans compared with Caucasians (allele frequencies 0.381 versus 0.040)

SNP ID	Valid	Clinical significance	Chr 4 pos	Sequence	#	AA Chg	Type	More	#	Allele freq	Pop	Total sample	More
Genomic Data					Transcription Related Data				Allele Frequencies
				--	--	--		--	--
rs76020435^1,2	F	--	3703579(+)	`CAGGCC/GCCCCT`	1	--	us2k¹		1		WA	118
rs76323688^1,2	C,F	--	3703638(+)	`GCCGAC/TCATGA`	1	--	us2k¹		1		WA	118
rs28576409^1,2	C	--	3703715(+)	`TTTAGG/TCAACC`	1	--	us2k¹		0	--	--	--	--
rs61754810^1,2	C,F	--	3704069(+)	`TCTGAG/AGCTAA`	1	--	us2k¹		2		NS NA	600
rs75576268^1,2	C,F	--	3704303(+)	`GGACGT/GTTGGG`	1	--	us2k¹		5		WA CSA NA EA	362
rs74832750^1,2	F	--	3704482(+)	`GCACAT/GCTGCA`	1	--	us2k¹		1		NA	120
rs80277987^1,2	F	--	3704733(+)	`AGACAC/ACGCCG`	1	--	us2k¹		1		WA	118
rs116893661^1,2	F	--	3766329(+)	`AAGCCG/ATAGCT`	2	--	us2k¹		1		EA	120
rs148087727^1,2		--	3766388(+)	`CAGCAA/GAGAAC`	2	--	us2k¹		0	--	--	--	--
rs140988404^1,2		--	3766828(+)	`TGCAGA/GATGGA`	2	--	us2k¹		0	--	--	--	--

HapMap Linkage Disequilibrium report for ADRA2C (3768075 - 3770253 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 4 variations for ADRA2C
4 CNVs: 51390 68633 51391 3477
Human Gene Mutation Database (HGMD): ADRA2C

SABiosciences Cancer Mutation PCR Assays

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(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
About This Section

ADRA2C for disorders           About GeneDecksing

OMIM gene information: 104250    OMIM disorders: --

20/30 diseases for ADRA2C (see all 30):    About MalaCards

congestive heart failure and beta-blocker response, modifier of attention deficit hyperactivity disorder congestive heart failure long qt syndrome

orthostatic intolerance type 2 diabetes mellitus bipolar affective disorder learning disability

irritable bowel syndrome neuronitis diabetes mellitus conduct disorder

dilated cardiomyopathy tourette syndrome mood disorder dyspepsia

myocardial infarction neurologic diseases adhd cardiomyopathy

1 disease from the University of Copenhagen DISEASES database for ADRA2C:

Attention deficit hyperactivity disorder

3 Novoseek disease relationships for ADRA2C gene About this table

Disease	-log (P-Val)	Hits	PubMed IDs for Articles with Shared Sentences (# sentences)
raynauds phenomenon	72.7	1	15593189 (1)
attention-deficit hyperactivity disorder	43.1	2	10334470 (1), 18835330 (1)
heart failure	34.2	7	19880803 (2), 17643402 (1), 12374873 (1), 18320080 (1) (see all 6)

Genetic Association Database (GAD): ADRA2C
Human Genome Epidemiology (HuGE) Navigator: ADRA2C (48 documents)

Export disorders for ADRA2C gene to outside databases

(in PubMed. Associations of this gene to articles via ¹Entrez Gene, ²UniProtKB/Swiss-Prot, ³HGNC, ⁴GAD, ⁵PharmGKB, ⁶HMDB, ⁷DrugBank, ⁸UniProtKB/TrEMBL, ⁹ Novoseek, and/or ¹⁰fRNAdb)
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PubMed articles for ADRA2C gene, integrated from 9 sources (see all 157):
(articles sorted by number of sources associating them with ADRA2C)

Utopia: connect your pdf to the dynamic
world of online information

Identification of an additional gene belonging to the alpha 2 adrenergic receptor family in the human genome by PCR. (PubMed id 1849485)^{1, 2, 3, 9} Chhajlani V.... Wikberg J.E.S. (1991)
Identification of a naturally occurring 21 bp deletion in alpha 2c noradrenergic receptor gene and cognitive correlates to antipsychotic treatment. (PubMed id 15683753)^{1, 4, 9} De Luca V....Kennedy J.L. (2005)
A screen of candidate genes and influence of beta2-adrenergic receptor genotypes in postural tachycardia syndrome. (PubMed id 15946904)^{1, 4, 9} Nickander K.K....Low P.A. (2005)
Synergistic polymorphisms of beta1- and alpha2C-adrenergic receptors and the risk of congestive heart failure. (PubMed id 12374873)^{1, 4, 9} Small K.M....Liggett S.B. (2002)
A four amino acid deletion polymorphism in the third intracellular loop of the human alpha 2C-adrenergic receptor confers impaired coupling to multiple effectors. (PubMed id 10801795)^{1, 2, 9} Small K.M.... Liggett S.B. (2000)
Alpha2C-adrenoceptor polymorphism is associated with improved event-free survival in patients with dilated cardiomyopathy. (PubMed id 16299019)^{1, 4} Regitz-Zagrosek V....Hein L. (2006)
Functional adrenergic receptor polymorphisms and idiopathic orthostatic intolerance. (PubMed id 15719258)^{1, 4} Winker R....Rudiger H.W. (2005)
Haplotype-based analysis of alpha 2A, 2B, and 2C adrenergic receptor genes captures information on common functional loci at each gene. (PubMed id 15592690)^{1, 4} Belfer I....Goldman D. (2005)
No positive association between adrenergic receptor variants of alpha2cDel322-325, beta1Ser49, beta1Arg389 and the risk for heart failure in the Japanese population. (PubMed id 16187973)^{1, 4} Nonen S....Kitabatake A. (2005)
Sympathoneural and adrenomedullary functional effects of alpha2C-adrenoreceptor gene polymorphism in healthy humans. (PubMed id 15861038)^{1, 4} Neumeister A....Goldstein D.S. (2005)

(in PubMed, OMIM, and NCBI Bookshelf)
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		AND	OR
Aliases
Disorders
Free Text

Query String		PubMed OMIM NCBI Bookshelf
	(Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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Entrez Gene: 152	HGNC: 283	AceView: ADRA2C	Ensembl:ENSG00000184160	euGenes: HUgn152
ECgene: ADRA2C	Kegg: 152	H-InvDB: ADRA2C

(According to HUGE)
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(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
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Name	Description
PharmGKB entry for ADRA2C	Pharmacogenomics, SNPs, Pathways

Intellectual Property for ADRA2C gene
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Patent Information for ADRA2C gene:
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ADRA2C Gene

adrenoceptor alpha 2C

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ADRA2C Gene

adrenoceptor alpha 2C

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