Aliases for ADRA2C Gene
External Ids for ADRA2C Gene
Previous HGNC Symbols for ADRA2C Gene
Previous GeneCards Identifiers for ADRA2C Gene
Alpha-2-adrenergic receptors are members of the G protein-coupled receptor superfamily. They include 3 highly homologous subtypes: alpha2A, alpha2B, and alpha2C. These receptors have a critical role in regulating neurotransmitter release from sympathetic nerves and from adrenergic neurons in the central nervous system. The mouse studies revealed that both the alpha2A and alpha2C subtypes were required for normal presynaptic control of transmitter release from sympathetic nerves in the heart and from central noradrenergic neurons. The alpha2A subtype inhibited transmitter release at high stimulation frequencies, whereas the alpha2C subtype modulated neurotransmission at lower levels of nerve activity. This gene encodes the alpha2C subtype, which contains no introns in either its coding or untranslated sequences. [provided by RefSeq, Jul 2008]
GeneCards Summary for ADRA2C Gene
ADRA2C (Adrenoceptor Alpha 2C) is a Protein Coding gene. Diseases associated with ADRA2C include orthostatic intolerance and congestive heart failure. Among its related pathways are Signaling by GPCR and Activation of cAMP-Dependent PKA. GO annotations related to this gene include protein homodimerization activity and alpha-2A adrenergic receptor binding. An important paralog of this gene is HTR1F.
UniProtKB/Swiss-Prot for ADRA2C Gene
Alpha-2 adrenergic receptors mediate the catecholamine-induced inhibition of adenylate cyclase through the action of G proteins
Adrenergic alpha2 receptors (alpha2-adrenoceptors) are members of the adrenergic receptor group of G-protein-coupled receptors that also includes alpha1A, alpha1B, alpha1D, beta1, beta2 and beta3. Adrenergic alpha2 receptors are divided into three subtypes: alpha2A, alpha2B and alpha2C, which are widely distributed in both the CNS and periphery. Alpha2-adrenoceptors play a role in the modulation of neurotransmission, smooth muscle contraction and thermoregulation. A fourth pharmacological subtype, alpha2D, has been identified in the rat which is thought to be a species ortholog of the human alpha2A subtype.