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ADRA2C Gene

protein-coding   GIFtS: 67
GCID: GC04P003804

Adrenoceptor Alpha 2C

(Previous names: adrenergic, alpha-2C-, receptor)
(Previous symbols: ADRA2L2, ADRA2RL2)
  See ADRA2C-related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Adrenoceptor Alpha 2C1 2     ADRARL22
ADRA2L21 2 3 5     ALPHA2CAR2
ADRA2RL21 2 3     alpha-2CAR2
Adrenergic, Alpha-2C-, Receptor1 2     Alpha-2C Adrenergic Receptor2
Alpha-2 Adrenergic Receptor Subtype C42 3     Alpha-2C-Adrenergic Receptor2
Alpha-2C Adrenoceptor2 3     alpha2-AR-C42
Alpha-2C Adrenoreceptor2 3     Alpha-2CAR3

External Ids:    HGNC: 2831   Entrez Gene: 1522   Ensembl: ENSG000001841607   OMIM: 1042505   UniProtKB: P188253   

Export aliases for ADRA2C gene to outside databases

Previous GC identifers: GC04U990002 GC04M9J0040 GC04P003798


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for ADRA2C Gene:
Alpha-2-adrenergic receptors are members of the G protein-coupled receptor superfamily. They include 3 highly
homologous subtypes: alpha2A, alpha2B, and alpha2C. These receptors have a critical role in regulating
neurotransmitter release from sympathetic nerves and from adrenergic neurons in the central nervous system. The
mouse studies revealed that both the alpha2A and alpha2C subtypes were required for normal presynaptic control of
transmitter release from sympathetic nerves in the heart and from central noradrenergic neurons. The alpha2A
subtype inhibited transmitter release at high stimulation frequencies, whereas the alpha2C subtype modulated
neurotransmission at lower levels of nerve activity. This gene encodes the alpha2C subtype, which contains no
introns in either its coding or untranslated sequences. (provided by RefSeq, Jul 2008)

GeneCards Summary for ADRA2C Gene:
ADRA2C (adrenoceptor alpha 2C) is a protein-coding gene. Diseases associated with ADRA2C include congestive heart failure and beta-blocker response, modifier of, and orthostatic intolerance. GO annotations related to this gene include alpha-2A adrenergic receptor binding and protein homodimerization activity. An important paralog of this gene is HTR1A.

UniProtKB/Swiss-Prot: ADA2C_HUMAN, P18825
Function: Alpha-2 adrenergic receptors mediate the catecholamine-induced inhibition of adenylate cyclase through
the action of G proteins

summary for ADRA2C Gene:
Adrenergic alpha2 receptors (alpha2-adrenoceptors) are members of the adrenergic receptor group of
G-protein-coupled receptors that also includes alpha1A, alpha1B, alpha1D, beta1, beta2 and beta3. Adrenergic
alpha2 receptors are divided into three subtypes: alpha2A, alpha2B and alpha2C, which are widely distributed
in both the CNS and periphery. Alpha2-adrenoceptors play a role in the modulation of neurotransmission,
smooth muscle contraction and thermoregulation. A fourth pharmacological subtype, alpha2D, has been
identified in the rat which is thought to be a species ortholog of the human alpha2A subtype.

Gene Wiki entry for ADRA2C (Alpha-2C adrenergic receptor) Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000004.11  NC_018915.2  NT_006051.19  
Regulatory elements:
   Regulatory transcription factor binding sites in the ADRA2C gene promoter:
         Bach1   E2F-3a   E2F-4   E2F-5   STAT1beta   E2F-2   MEF-2A   E2F-1   E2F   aMEF-2   
         Other transcription factors

Browse SwitchGear Promoter luciferase reporter plasmids
   Search Chromatin IP Primers for ADRA2C

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat ADRA2C


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 4p16   Ensembl cytogenetic band:  4p16.3   HGNC cytogenetic band: 4p16.3

ADRA2C Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
ADRA2C gene location

GeneLoc information about chromosome 4         GeneLoc Exon Structure

GeneLoc location for GC04P003804:  view genomic region     (about GC identifiers)

Start:
3,768,075 bp from pter      End:
3,770,253 bp from pter
Size:
2,179 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., and/or eBioscience,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., and/or eBioscience, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: ADA2C_HUMAN, P18825 (See protein sequence)
Recommended Name: Alpha-2C adrenergic receptor  
Size: 462 amino acids; 49522 Da
Sequence caution: Sequence=AAA35513.1; Type=Frameshift; Positions=270, 296, 300; Sequence=AAC78723.1;
Type=Frameshift; Positions=270, 296, 300;
Secondary accessions: P35369 Q9HB49

Explore the universe of human proteins at neXtProt for ADRA2C: NX_P18825

Explore proteomics data for ADRA2C at MOPED

Post-translational modifications: 

  • Glycosylation2 at Asn19, Asn33
  • Modification sites at PhosphoSitePlus

  • See ADRA2C Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_000674.2  
    ENSEMBL proteins: 
     ENSP00000426268   ENSP00000386069  
    Reactome Protein details: P18825

    ADRA2C Human Recombinant Protein Products:

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    Novus Biologicals ADRA2C Lysate
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    Browse Sino Biological Cell Lysates
    Browse ProSpec Recombinant Proteins
    Browse Proteins at Cloud-Clone Corp.

     
    Search eBioscience for Proteins for ADRA2C 

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    Browse ELISAs at Cloud-Clone Corp.
    Browse CLIAs at Cloud-Clone Corp.
    Search eBioscience for ELISAs for ADRA2C 


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    ADRA: GPCR / Class A : Adrenoceptors : alpha

    IUPHAR Guide to PHARMACOLOGY protein family classification: alpha2C-adrenoceptor
    Adrenoceptors

    4 InterPro protein domains:
     IPR017452 GPCR_Rhodpsn_7TM
     IPR000735 ADRA2C_rcpt
     IPR002233 ADR_fam
     IPR000276 GPCR_Rhodpsn

    Graphical View of Domain Structure for InterPro Entry P18825

    ProtoNet protein and cluster: P18825

    2 Blocks protein domains:
    IPB000735 Alpha-2C adrenergic receptor signature
    IPB002233 Adrenergic receptor signature


    UniProtKB/Swiss-Prot: ADA2C_HUMAN, P18825
    Similarity: Belongs to the G-protein coupled receptor 1 family. Adrenergic receptor subfamily. ADRA2C
    sub-subfamily


    Find genes that share domains with ADRA2C           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: ADA2C_HUMAN, P18825
    Function: Alpha-2 adrenergic receptors mediate the catecholamine-induced inhibition of adenylate cyclase through
    the action of G proteins

         Genatlas biochemistry entry for ADRA2C:
    adrenergic,alpha-2C-,receptor,G protein coupled receptor superfamily,without action on ion channels

         Gene Ontology (GO): Selected molecular function terms (see all 7):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0004930G-protein coupled receptor activity ----
    GO:0004938alpha2-adrenergic receptor activity IDA17215105
    GO:0005515protein binding IPI16531006
    GO:0031694alpha-2A adrenergic receptor binding IPI16605244
    GO:0042803protein homodimerization activity IDA16605244
         
    Find genes that share ontologies with ADRA2C           About GenesLikeMe


    Phenotypes:
         2 GenomeRNAi human phenotypes for ADRA2C:
     Decreased substrate adherent c  Increased HPV18 LCR reporter a 

         6 MGI mutant phenotypes (inferred from 1 allele(MGI details for Adra2c):
     behavior/neurological  cardiovascular system  embryogenesis  homeostasis/metabolism  mortality/aging 
     nervous system 

    Find genes that share phenotypes with ADRA2C           About GenesLikeMe

    Animal Models:
         MGI mouse knock-out Adra2ctm1Gsb for ADRA2C

       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for ADRA2C
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    miRNA
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    hsa-miR-520d-5p hsa-miR-1271 hsa-miR-219-5p hsa-miR-182 hsa-miR-659 hsa-miR-376a* hsa-miR-129-3p hsa-miR-524-5p
    SwitchGear 3'UTR luciferase reporter plasmidADRA2C 3' UTR sequence
    Inhib. RNA
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    Gene Editing
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    Clone
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    GenScript: all cDNA clones in your preferred vector: ADRA2C (NM_000683)
    Browse Sino Biological Human cDNA Clones
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    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat ADRA2C

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    Flow Cytometry
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    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    ADA2C_HUMAN, P18825: Cell membrane; Multi-pass membrane protein
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    plasma membrane5
    endosome4
    nucleus1

    Gene Ontology (GO): Selected cellular component terms (see all 7):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005737cytoplasm IDA16605244
    GO:0005768endosome TAS10196213
    GO:0005886plasma membrane TAS--
    GO:0005887integral component of plasma membrane IDA16605244
    GO:0016021integral component of membrane ----

    Find genes that share ontologies with ADRA2C           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for ADRA2C About   (see all 12)  
    See pathways by source

    SuperPathContained pathways About
    1Peptide ligand-binding receptors
    Class A/1 (Rhodopsin-like receptors)0.71
    GPCRs, Class A Rhodopsin-like0.43
    GPCR ligand binding0.71
    Neuroactive ligand-receptor interaction0.36
    G alpha (i) signalling events0.44
    2Monoamine GPCRs
    Monoamine GPCRs0.79
    Adrenoceptors0.00
    Amine ligand-binding receptors0.79
    Adrenaline signalling through Alpha-2 adrenergic receptor0.00
    3Signaling by GPCR
    Signaling by GPCR0.90
    Signal Transduction0.58
    GPCR downstream signaling0.90
    4Activation of cAMP-Dependent PKA
    Activation of cAMP-Dependent PKA0.77
    Activation of PKA through GPCR0.71
    cAMP Pathway0.77
    5Integration of energy metabolism
    Integration of energy metabolism0.75
    Regulation of Insulin Secretion0.75


    Find genes that share SuperPaths with ADRA2C           About GenesLikeMe

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    4 Downloadable PowerPoint Slides of GeneGlobe Pathway Central Maps for ADRA2C
        Activation of PKA through GPCR
    AMPK Enzyme Complex Pathway
    cAMP Pathway
    Activation of cAMP-Dependent PKA

    1 GeneGo (Thomson Reuters) Pathway for ADRA2C
        Development Alpha-2 adrenergic receptor activation of ERK

    2 BioSystems Pathways for ADRA2C
        GPCRs, Class A Rhodopsin-like
    Monoamine GPCRs

    5 Reactome Pathways for ADRA2C
        G alpha (i) signalling events
    Adrenaline,noradrenaline inhibits insulin secretion
    Adrenaline signalling through Alpha-2 adrenergic receptor
    Adrenoceptors
    G alpha (z) signalling events

    1 PharmGKB Pathway for ADRA2C
        Sympathetic Nerve Pathway (Neuroeffector Junction)

    1 Kegg Pathway  (Kegg details for ADRA2C):
        Neuroactive ligand-receptor interaction

        Pathway & Disease-focused RT2 Profiler PCR Array including ADRA2C: 
              G Protein Coupled Receptors 384HT in human mouse rat

    Interactions:

        GeneGlobe Interaction Network for ADRA2C

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for ADRA2C (P188253 ENSP000003860694) via UniProtKB, MINT, STRING, and/or I2D (see all 151)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    GNAO1P094713, ENSP000002624934I2D: score=1 STRING: ENSP00000262493
    YWHAZP631043, ENSP000003095034I2D: score=2 STRING: ENSP00000309503
    EIF2B1Q142323I2D: score=3 
    PPP1R9BQ96SB33I2D: score=2 
    ADCY2ENSP000003429524STRING: ENSP00000342952
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 19):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006112energy reserve metabolic process TAS--
    GO:0006940regulation of smooth muscle contraction ----
    GO:0007186G-protein coupled receptor signaling pathway TAS9371698
    GO:0007267cell-cell signaling TAS9371698
    GO:0007565female pregnancy IEA--

    Find genes that share ontologies with ADRA2C           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Compounds for ADRA2C available from Tocris Bioscience    About this table
    CompoundAction CAS #
    JP 1302 dihydrochloridePotent and selective alpha2C antagonist[80259-18-3]
    BRL 44408 maleateSelective alpha2A antagonist[118343-19-4]
    Atipamezole hydrochlorideSelective alpha2 antagonist[104075-48-1]
    Medetomidine hydrochloride Potent, highly selective alpha2 agonist [106807-72-1]
    Dexmedetomidine hydrochloride Potent, highly selective alpha2 agonist. Active isomer of medetomidine (Cat. No. 2023) [145108-58-3]

    1 HMDB Compound for ADRA2C    About this table
    CompoundSynonyms CAS #PubMed Ids
    Norepinephrine(-)-(R)-Norepinephrine (see all 32)51-41-2--

    Selected DrugBank Compounds for ADRA2C (see all 33)    About this table
    CompoundSynonyms CAS #TypeActionsPubMed Ids
    NorepinephrineArterenol (see all 4)51-41-2targetagonist1654268 18064417 17410123 1980236 17139284 8590979 17016423
    Yohimbine-- 146-48-5targetantagonist12438517 10611634 16176444 11226402 12591093 12110610
    BethanidineBetanidine (see all 2)55-73-2targetagonist1962798 17139284 17016423 2545383
    BrimonidineBrimonidine tartrate (see all 2)59803-98-4targetagonist11606316 16757535 12670699 14610637
    BromocriptineBromergocryptine (see all 10)25614-03-3targetagonist10641988 18691132 20138024
    CabergolineCabergolina [Spanish] (see all 2)81409-90-7targetantagonist10641988 18691132 12388667
    DroxidopaDroxydopa (see all 4)23651-95-8targetagonist18680204 21173850 8590979
    EphedraChinese jointfir (see all 3)--targetagonist12954796 14570629 15955613
    FenoldopamFenodopam mesylate (see all 3)67227-57-0targetantagonist17139284 7670737 17016423
    Methotrimeprazine-- 60-99-1targetantagonist2870716 6149771 15701205

    Selected IUPHAR Ligands for ADRA2C (alpha2C-adrenoceptor) (see all 30)    About this table
    LigandTypeActionAffinityPubmed IDs
    [3H]MK-912
    AntagonistAntagonist10.17996470
    lisuride
    AntagonistAntagonist9.912388666
    [3H]rauwolscine
    AntagonistAntagonist9.98819505 1353247
    yohimbine
    AntagonistAntagonist8.5 - 9.57908642 7996470 1353247
    WB 4101
    AntagonistAntagonist8.4 - 9.47908642 7996470 1353247
    dexmedetomidine
    AgonistFull agonist7 - 9.39605427 9760042 9824686
    [3H]RX821002
    AntagonistAntagonist8.2 - 9.27908642 8819505
    rauwolscine
    AntagonistAntagonist9.17996470
    terguride
    AntagonistAntagonist9.112388666
    spiroxatrine
    AntagonistAntagonist97996470

    6 Novoseek inferred chemical compound relationships for ADRA2C gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    norepinephrine 59 6 15946904 (1), 18947427 (1), 10334470 (1), 16188498 (1) (see all 5)
    yohimbine 54.9 2 16873606 (1), 15911252 (1)
    forskolin 25.3 2 18487435 (1), 10999953 (1)
    catecholamine 24.9 2 17075692 (1), 17643402 (1)
    tyrosine 1.72 2 19037602 (1)
    dopamine 0 2 10334470 (1)

    2 PharmGKB related drug/compound annotations for ADRA2C gene    About this table
    Drug/compound PharmGKB Annotation
    bucindololCA  
    clonidineCA  



    Find genes that share compounds with ADRA2C           About GenesLikeMe



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for ADRA2C gene: 
    NM_000683.3  

    Unigene Cluster for ADRA2C:

    Adrenoceptor alpha 2C
    Hs.123022  [show with all ESTs]
    Unigene Representative Sequence: BC142625
    2 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000509482 ENST00000330055(uc003ghm.3)
    miRNA
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    Selected qRT-PCR Assays for microRNAs that regulate ADRA2C (see all 10):
    hsa-miR-520d-5p hsa-miR-1271 hsa-miR-219-5p hsa-miR-182 hsa-miR-659 hsa-miR-376a* hsa-miR-129-3p hsa-miR-524-5p
    SwitchGear 3'UTR luciferase reporter plasmidADRA2C 3' UTR sequence
    Inhib. RNA
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    Predesigned siRNA for gene silencing in human, mouse, rat ADRA2C
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    GenScript: all cDNA clones in your preferred vector: ADRA2C (NM_000683)
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    Primer
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      QuantiTect SYBR Green Assays in human, mouse, rat ADRA2C
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    Flow Cytometry
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    eBioscience FlowRNA Probe Sets ( VA1-11946 VF1-11951) for ADRA2C 

    Additional mRNA sequence: 

    BC142625.1 J03853.1 

    2 DOTS entries:

    DT.206046  DT.121235832 

    Selected AceView cDNA sequences (see all 29):

    AW072770 CR590957 AI492607 CD673805 BU539106 BG830756 T40595 CB215653 
    AA458485 BU538114 AL544609 AI831889 J03853 AL549866 AI539550 BM987577 
    T39448 AA010313 AL530417 NM_000683 AA936098 CB217117 AL573897 BU538113 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    ADRA2C expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: GGCGTGTTCG
    ADRA2C Expression
    About this image


    ADRA2C expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     
     Brain (Nervous System)    fully expand to see all 17 entries
             Thalamus
             striatum   
    ADRA2C Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    ADRA2C Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.123022
        Pathway & Disease-focused RT2 Profiler PCR Array including ADRA2C: 
              G Protein Coupled Receptors 384HT in human mouse rat

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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of animals.

    Orthologs for ADRA2C gene from Selected species (see all 13)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Adra2c1 , 5 adrenergic receptor, alpha 2c1, 5 84.3(n)1
    89.06(a)1
      5 (18.09 cM)5
    115531  NM_007418.31  NP_031444.21 
     352785665 
    chicken
    (Gallus gallus)
    Aves ADRA2C1 adrenergic, alpha-2C-, receptor 72.07(n)
    74.68(a)
      428799  XM_004936302.1  XP_004936359.1 
    lizard
    (Anolis carolinensis)
    Reptilia --
    Uncharacterized protein
    45(a)
    many ↔ many
    2(145952828-145954135)
    African clawed frog
    (Xenopus laevis)
    Amphibia Xl.263962 Xenopus laevis transcribed sequence with moderate similarity more 77.72(n)    CD361190.1 
    zebrafish
    (Danio rerio)
    Actinopterygii NM_194364.12   -- 81.15(n)   266754  NM_194364.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta CG182083   -- 49(a)
    (best of 3)
        --
    worm
    (Caenorhabditis elegans)
    Secernentea sca-13 E1-E2 ATPases 31(a)
    (best of 2)
      X(16610545-16618262)   --


    ENSEMBL Gene Tree for ADRA2C (if available)
    TreeFam Gene Tree for ADRA2C (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for ADRA2C gene
    HTR1A2  ADRA1B2  HTR1F2  HTR72  ADRA2A2  HTR1D2  ADRA2B2  ADRA1A2  
    HTR1E2  HTR5A2  HTR1B2  ADRA1D2  
    18 SIMAP similar genes for ADRA2C using alignment to 3 protein entries:     ADA2C_HUMAN (see all proteins):
    ADORA2A    ADRA2A    ADRA2B    HTR2A    HTR2B    HTR2C
    ADRA1A    GHSR    ADRB2    DRD2    5HT1A    HTR1A
    DRD5P1    CCR5    GPR85    HTR1D    HTR1F    HRH3

    Find genes that share paralogs with ADRA2C           About GenesLikeMe



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Polymorphic Variants from UniProtKB/Swiss-Prot
    ADA2C_HUMAN, P18825: The Del322-325 variant has a significant loss of function. It is approximately 10 times more
    frequent in African-Americans compared with Caucasians (allele frequencies 0.381 versus 0.040)


    Selected SNPs for ADRA2C (see all 83)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 4 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs779621191,2
    F--3767136(+) GCCGGG/CGTGGG 1 -- us2k11Minor allele frequency- C:0.04WA 118
    rs1820961611,2
    C--3767369(+) TCTTAC/GAAAGA 1 -- us2k10--------
    rs97144311,2
    C,F,H--3767394(+) TCACCG/ACCCAG 1 -- us2k117Minor allele frequency- A:0.17NS EA NA CSA 2091
    rs614641941,2
    F--3767821(+) GCGCGC/TGGCGG 1 -- us2k11Minor allele frequency- T:0.19--382
    rs1123515021,2
    C--3767996(+) GCTCGC/ACGCCG 1 -- us2k11Minor allele frequency- A:0.00NA 2
    rs1389483591,2
    --3768104(+) CCTCCC/TGCTCT 1 -- us2k10--------
    rs1867496621,2
    --3768172(+) CCCGCA/GGAGCC 1 -- us2k10--------
    rs1903360611,2
    --3768371(+) GGTGGC/GGGCAG 2 A G mis10--------
    rs1463703851,2
    C--3768645(+) CTGGTA/CATGCC 2 V syn10--------
    rs1384575041,2
    C--3768741(+) TGCACC/GTCGTC 2 T syn10--------

    HapMap Linkage Disequilibrium report for ADRA2C (3768075 - 3770253 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 9 variations for ADRA2C:    About this table    
    Variant IDTypeSubtypePubMed ID
    dgv5441n71CNV Loss21882294
    nsv519631CNV Loss19592680
    dgv5438n71CNV Loss21882294
    dgv5440n71CNV Loss21882294
    nsv878509CNV Loss21882294
    nsv878471CNV Loss21882294
    esv26274CNV Loss19812545
    dgv854n67CNV Gain20364138
    dgv1566e1CNV Complex17122850

    Human Gene Mutation Database (HGMD): ADRA2C
    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing ADRA2C
    DNA2.0 Custom Variant and Variant Library Synthesis for ADRA2C

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 104250    OMIM disorders: --

    8 diseases for ADRA2C:    
    About MalaCards
    congestive heart failure and beta-blocker response, modifier of    orthostatic intolerance    congestive heart failure    irritable bowel syndrome
    neurologic diseases    dyspepsia    mood disorder    attention deficit hyperactivity disorder

    1 disease from the University of Copenhagen DISEASES database for ADRA2C:
    Attention deficit hyperactivity disorder

    Find genes that share disorders with ADRA2C           About GenesLikeMe

    3 Novoseek inferred disease relationships for ADRA2C gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    raynauds phenomenon 72.7 1 15593189 (1)
    attention-deficit hyperactivity disorder 43.1 2 10334470 (1), 18835330 (1)
    heart failure 34.2 7 19880803 (2), 17643402 (1), 12374873 (1), 18320080 (1) (see all 6)

    Genetic Association Database (GAD): ADRA2C
    Human Genome Epidemiology (HuGE) Navigator: ADRA2C (48 documents)

    Export disorders for ADRA2C gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for ADRA2C gene, integrated from 10 sources (see all 164):
    (articles sorted by number of sources associating them with ADRA2C)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Identification of an additional gene belonging to the alpha 2 adrenergic receptor family in the human genome by PCR. (PubMed id 1849485)1, 2, 3, 9 Chhajlani V.... Wikberg J.E.S. (FEBS Lett. 1991)
    2. Association between the alpha-2C-adrenergic receptor gene and attention deficit hyperactivity disorder in a Korean sample. (PubMed id 18835330)1, 4, 9 Cho S.C....Park T.W. (Neurosci. Lett. 2008)
    3. Do allelic variants in alpha2A and alpha2C adrenergic receptors predispose to hypertension in blacks? (PubMed id 16636200)1, 4, 9 Li J.L....Victor R.G. (Hypertension 2006)
    4. An alpha2C-adrenergic receptor polymorphism alters the norepinephrine-lowering effects and therapeutic response of the beta-blocker bucindolol in chronic heart failure. (PubMed id 19880803)1, 4, 9 Bristow M.R....Liggett S.B. (Circ Heart Fail 2010)
    5. Alpha-adrenoceptor gene variants and autonomic nervous system function in a young healthy Japanese population. (PubMed id 17075692)1, 4, 9 Matsunaga T....Tsuda K. (J. Hum. Genet. 2007)
    6. Effect of the alpha2C-adrenoreceptor deletion322-325 variant on sympathetic activity and cardiovascular measures in healthy subjects. (PubMed id 17351367)1, 4, 9 Kurnik D....Stein C.M. (J. Hypertens. 2007)
    7. Identification of a naturally occurring 21 bp deletion in alpha 2c noradrenergic receptor gene and cognitive correlates to antipsychotic treatment. (PubMed id 15683753)1, 4, 9 De Luca V....Kennedy J.L. (Pharmacol. Res. 2005)
    8. A screen of candidate genes and influence of beta2-adrenergic receptor genotypes in postural tachycardia syndrome. (PubMed id 15946904)1, 4, 9 Nickander K.K....Low P.A. (amp 2005)
    9. Synergistic polymorphisms of beta1- and alpha2C-adrenergic receptors and the risk of congestive heart failure. (PubMed id 12374873)1, 4, 9 Small K.M....Liggett S.B. (N. Engl. J. Med. 2002)
    10. The alpha2C-adrenoceptor deletion322-325 variant and cold-induced vasoconstriction. (PubMed id 19444546)1, 4, 9 Friedman E.A....Kurnik D. (Clin. Auton. Res. 2009)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 152 HGNC: 283 AceView: ADRA2C Ensembl:ENSG00000184160 euGenes: HUgn152
    ECgene: ADRA2C Kegg: 152 H-InvDB: ADRA2C

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
    About This Section

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    NameDescription
    PharmGKB entry for ADRA2C Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section

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    Patent Information for ADRA2C gene:
    Search GeneIP for patents involving ADRA2C

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, eBioscience, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
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