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Aliases for ADRA2C Gene

Aliases for ADRA2C Gene

  • Adrenoceptor Alpha 2C 2 3
  • Alpha-2 Adrenergic Receptor Subtype C4 3 4
  • Adrenergic, Alpha-2C-, Receptor 2 3
  • Alpha-2C Adrenoreceptor 3 4
  • Alpha-2C Adrenoceptor 3 4
  • Alpha-2CAR 3 4
  • ADRA2RL2 3 4
  • ADRA2L2 3 4
  • Alpha-2C-Adrenergic Receptor 3
  • Alpha2-AR-C4 3
  • ALPHA2CAR 3
  • ADRARL2 3

External Ids for ADRA2C Gene

Previous HGNC Symbols for ADRA2C Gene

  • ADRA2L2
  • ADRA2RL2

Previous GeneCards Identifiers for ADRA2C Gene

  • GC04U990002
  • GC04M9J0040
  • GC04P003798

Summaries for ADRA2C Gene

Entrez Gene Summary for ADRA2C Gene

  • Alpha-2-adrenergic receptors are members of the G protein-coupled receptor superfamily. They include 3 highly homologous subtypes: alpha2A, alpha2B, and alpha2C. These receptors have a critical role in regulating neurotransmitter release from sympathetic nerves and from adrenergic neurons in the central nervous system. The mouse studies revealed that both the alpha2A and alpha2C subtypes were required for normal presynaptic control of transmitter release from sympathetic nerves in the heart and from central noradrenergic neurons. The alpha2A subtype inhibited transmitter release at high stimulation frequencies, whereas the alpha2C subtype modulated neurotransmission at lower levels of nerve activity. This gene encodes the alpha2C subtype, which contains no introns in either its coding or untranslated sequences. [provided by RefSeq, Jul 2008]

GeneCards Summary for ADRA2C Gene

ADRA2C (Adrenoceptor Alpha 2C) is a Protein Coding gene. Diseases associated with ADRA2C include raynaud disease and orthostatic intolerance. Among its related pathways are Signaling by GPCR and Activation of cAMP-Dependent PKA. GO annotations related to this gene include G-protein coupled receptor activity and protein heterodimerization activity. An important paralog of this gene is HTR1F.

UniProtKB/Swiss-Prot for ADRA2C Gene

  • Alpha-2 adrenergic receptors mediate the catecholamine-induced inhibition of adenylate cyclase through the action of G proteins

Tocris Summary for ADRA2C Gene

  • Adrenergic alpha2 receptors (alpha2-adrenoceptors) are members of the adrenergic receptor group of G-protein-coupled receptors that also includes alpha1A, alpha1B, alpha1D, beta1, beta2 and beta3. Adrenergic alpha2 receptors are divided into three subtypes in humans: alpha2A, alpha2B and alpha2C.

Gene Wiki entry for ADRA2C Gene

No data available for PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ADRA2C Gene

Genomics for ADRA2C Gene

Regulatory Elements for ADRA2C Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for ADRA2C Gene

Chromosome:
4
Start:
3,766,348 bp from pter
End:
3,768,526 bp from pter
Size:
2,179 bases
Orientation:
Plus strand

Genomic View for ADRA2C Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for ADRA2C Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ADRA2C Gene

Proteins for ADRA2C Gene

  • Protein details for ADRA2C Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P18825-ADA2C_HUMAN
    Recommended name:
    Alpha-2C adrenergic receptor
    Protein Accession:
    P18825
    Secondary Accessions:
    • P35369
    • Q9HB49

    Protein attributes for ADRA2C Gene

    Size:
    462 amino acids
    Molecular mass:
    49522 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=AAA35513.1; Type=Frameshift; Positions=270, 296, 300; Evidence={ECO:0000305}; Sequence=AAC78723.1; Type=Frameshift; Positions=270, 296, 300; Evidence={ECO:0000305};

neXtProt entry for ADRA2C Gene

Proteomics data for ADRA2C Gene at MOPED

Post-translational modifications for ADRA2C Gene

  • Glycosylation at Asn 19 and Asn 33
  • Modification sites at PhosphoSitePlus

Other Protein References for ADRA2C Gene

ENSEMBL proteins:
REFSEQ proteins:

Antibody Products

No data available for DME Specific Peptides for ADRA2C Gene

Domains & Families for ADRA2C Gene

Gene Families for ADRA2C Gene

Suggested Antigen Peptide Sequences for ADRA2C Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

P18825

UniProtKB/Swiss-Prot:

ADA2C_HUMAN :
  • Belongs to the G-protein coupled receptor 1 family. Adrenergic receptor subfamily. ADRA2C sub-subfamily.
Family:
  • Belongs to the G-protein coupled receptor 1 family. Adrenergic receptor subfamily. ADRA2C sub-subfamily.
genes like me logo Genes that share domains with ADRA2C: view

Function for ADRA2C Gene

Molecular function for ADRA2C Gene

GENATLAS Biochemistry:
adrenergic,alpha-2C-,receptor,G protein coupled receptor superfamily,without action on ion channels
UniProtKB/Swiss-Prot Function:
Alpha-2 adrenergic receptors mediate the catecholamine-induced inhibition of adenylate cyclase through the action of G proteins

Gene Ontology (GO) - Molecular Function for ADRA2C Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004930 G-protein coupled receptor activity --
GO:0004938 alpha2-adrenergic receptor activity IDA 17215105
GO:0005515 protein binding IPI 16531006
GO:0031694 alpha-2A adrenergic receptor binding IPI 16605244
GO:0042803 protein homodimerization activity IDA 16605244
genes like me logo Genes that share ontologies with ADRA2C: view
genes like me logo Genes that share phenotypes with ADRA2C: view

Animal Models for ADRA2C Gene

MGI Knock Outs for ADRA2C:

Animal Model Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for ADRA2C

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , miRNA , Transcription Factor Targets and HOMER Transcription for ADRA2C Gene

Localization for ADRA2C Gene

Subcellular locations from UniProtKB/Swiss-Prot for ADRA2C Gene

Cell membrane; Multi-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for ADRA2C Gene COMPARTMENTS Subcellular localization image for ADRA2C gene
Compartment Confidence
plasma membrane 5
endosome 4
nucleus 1

Gene Ontology (GO) - Cellular Components for ADRA2C Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm IDA 16605244
GO:0005768 endosome TAS 10196213
GO:0005886 plasma membrane TAS --
GO:0005887 integral component of plasma membrane IDA 16605244
GO:0016021 integral component of membrane --
genes like me logo Genes that share ontologies with ADRA2C: view

Pathways & Interactions for ADRA2C Gene

genes like me logo Genes that share pathways with ADRA2C: view

PCR Array Products

  • Pathway & Disease-focused RT² Profiler PCR Arrays

Gene Ontology (GO) - Biological Process for ADRA2C Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006112 energy reserve metabolic process TAS --
GO:0006940 regulation of smooth muscle contraction --
GO:0007186 G-protein coupled receptor signaling pathway TAS 9371698
GO:0007194 negative regulation of adenylate cyclase activity IBA --
GO:0007267 cell-cell signaling TAS 9371698
genes like me logo Genes that share ontologies with ADRA2C: view

No data available for SIGNOR curated interactions for ADRA2C Gene

Drugs & Compounds for ADRA2C Gene

(133) Drugs for ADRA2C Gene - From: IUPHAR, DGIdb, NovoSeek, DrugBank, HMDB, PharmGKB, and ApexBio

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Yohimbine Approved Pharma Antagonist, antagonist, Target 25
Clonidine Approved Pharma Partial agonist, Agonist, agonist, Target 177
Apomorphine Approved, Investigational Pharma Activation, Activator, agonist, Target 32
Brimonidine Approved Pharma Partial agonist, Agonist, agonist, Target 108
Bromocriptine Approved, Investigational Pharma Partial agonist, Agonist, agonist, Target 27

(6) Additional Compounds for ADRA2C Gene - From: Tocris, IUPHAR, and NovoSeek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
(plusmn)-adrenaline
Full agonist, Agonist
A 80426 mesylate
152148-64-6
Guanfacine hydrochloride
29110-48-3
ST 91
4749-61-5
UK 14,304 tartrate
70359-46-5
genes like me logo Genes that share compounds with ADRA2C: view

Transcripts for ADRA2C Gene

mRNA/cDNA for ADRA2C Gene

(1) REFSEQ mRNAs :
(2) Additional mRNA sequences :
(29) Selected AceView cDNA sequences:
(2) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for ADRA2C Gene

Adrenoceptor alpha 2C:
Representative Sequences:

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for ADRA2C

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for ADRA2C Gene

No ASD Table

Relevant External Links for ADRA2C Gene

GeneLoc Exon Structure for
ADRA2C
ECgene alternative splicing isoforms for
ADRA2C

Expression for ADRA2C Gene

mRNA expression in normal human tissues for ADRA2C Gene

mRNA differential expression in normal tissues according to GTEx for ADRA2C Gene

This gene is overexpressed in Artery - Aorta (x8.2), Cervix - Endocervix (x6.7), and Artery - Tibial (x4.8).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for ADRA2C Gene



SOURCE GeneReport for Unigene cluster for ADRA2C Gene Hs.123022

genes like me logo Genes that share expression patterns with ADRA2C: view

Primer Products

In Situ Assay Products

No data available for Protein differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Protein tissue co-expression partners for ADRA2C Gene

Orthologs for ADRA2C Gene

This gene was present in the common ancestor of animals.

Orthologs for ADRA2C Gene

Organism Taxonomy Gene Similarity Type Details
dog
(Canis familiaris)
Mammalia ADRA2C 35
  • 89.71 (n)
  • 89.03 (a)
ADRA2C 36
  • 90 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Adra2c 35
  • 84.3 (n)
  • 89.06 (a)
Adra2c 16
Adra2c 36
  • 94 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia ADRA2C 35
  • 98.62 (n)
  • 98.71 (a)
ADRA2C 36
  • 88 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Adra2c 35
  • 84.6 (n)
  • 88.62 (a)
oppossum
(Monodelphis domestica)
Mammalia ADRA2C 36
  • 67 (a)
OneToOne
chicken
(Gallus gallus)
Aves ADRA2C 35
  • 72.07 (n)
  • 74.68 (a)
ADRA2C 36
  • 69 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia -- 36
  • 45 (a)
ManyToMany
tropical clawed frog
(Silurana tropicalis)
Amphibia adra2c 35
  • 68.64 (n)
  • 72.04 (a)
African clawed frog
(Xenopus laevis)
Amphibia Xl.26396 35
zebrafish
(Danio rerio)
Actinopterygii -- 35
adra2c 35
  • 64.38 (n)
  • 68.07 (a)
adra2c 36
  • 63 (a)
OneToOne
fruit fly
(Drosophila melanogaster)
Insecta 5-HT7 37
  • 33 (a)
CG18208 37
  • 49 (a)
DopR2 37
  • 44 (a)
CG18208 36
  • 23 (a)
ManyToMany
Oct-TyrR 36
  • 24 (a)
ManyToMany
worm
(Caenorhabditis elegans)
Secernentea sca-1 37
  • 31 (a)
ser-1 37
  • 31 (a)
octr-1 36
  • 30 (a)
ManyToMany
ser-2 36
  • 30 (a)
ManyToMany
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 28 (a)
OneToMany
Species with no ortholog for ADRA2C:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • cow (Bos Taurus)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for ADRA2C Gene

ENSEMBL:
Gene Tree for ADRA2C (if available)
TreeFam:
Gene Tree for ADRA2C (if available)

Paralogs for ADRA2C Gene

Paralogs for ADRA2C Gene

(18) SIMAP similar genes for ADRA2C Gene using alignment to 3 proteins:

genes like me logo Genes that share paralogs with ADRA2C: view

Variants for ADRA2C Gene

Polymorphic Variants from UniProtKB/Swiss-Prot for ADRA2C Gene

P18825-ADA2C_HUMAN
The Del322-325 variant has a significant loss of function. It is approximately 10 times more frequent in African-Americans compared with Caucasians (allele frequencies 0.381 versus 0.040)

Structural Variations from Database of Genomic Variants (DGV) for ADRA2C Gene

Variant ID Type Subtype PubMed ID
dgv1566e1 CNV Complex 17122850
nsv878471 CNV Loss 21882294
dgv5438n71 CNV Loss 21882294
dgv5440n71 CNV Loss 21882294
dgv5441n71 CNV Loss 21882294
nsv519631 CNV Loss 19592680
nsv878509 CNV Loss 21882294
dgv854n67 CNV Gain 20364138
esv26274 CNV Loss 19812545

Variation tolerance for ADRA2C Gene

Residual Variation Intolerance Score: 34.15% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 8.58; 86.14% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for ADRA2C Gene

HapMap Linkage Disequilibrium report
ADRA2C
Human Gene Mutation Database (HGMD)
ADRA2C

No data available for Sequence variations from dbSNP and Humsavar for ADRA2C Gene

Disorders for ADRA2C Gene

MalaCards: The human disease database

(3) MalaCards diseases for ADRA2C Gene - From: DISEASES, NovoSeek, and GeneCards

Disorder Aliases PubMed IDs
raynaud disease
  • raynaud's syndrome
orthostatic intolerance
  • neurocirculatory asthenia
attention deficit-hyperactivity disorder
  • attention deficit hyperactivity disorder
- elite association

Relevant External Links for ADRA2C

Genetic Association Database (GAD)
ADRA2C
Human Genome Epidemiology (HuGE) Navigator
ADRA2C
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
ADRA2C
genes like me logo Genes that share disorders with ADRA2C: view

No data available for UniProtKB/Swiss-Prot and Genatlas for ADRA2C Gene

Publications for ADRA2C Gene

  1. Alpha2C-adrenergic receptors exhibit enhanced surface expression and signaling upon association with beta2-adrenergic receptors. (PMID: 16757535) Prinster S.C. … Hall R.A. (J. Pharmacol. Exp. Ther. 2006) 23 25 26 67
  2. Identification of an additional gene belonging to the alpha 2 adrenergic receptor family in the human genome by PCR. (PMID: 1849485) Chhajlani V. … Wikberg J.E.S. (FEBS Lett. 1991) 2 23 67
  3. An alpha2C-adrenergic receptor polymorphism alters the norepinephrine-lowering effects and therapeutic response of the beta-blocker bucindolol in chronic heart failure. (PMID: 19880803) Bristow M.R. … Liggett S.B. (Circ Heart Fail 2010) 23 67
  4. The dopamine receptor D2 agonist bromocriptine inhibits glucose-stimulated insulin secretion by direct activation of the alpha2-adrenergic receptors in beta cells. (PMID: 20138024) de Leeuw van Weenen J.E. … Guigas B. (Biochem. Pharmacol. 2010) 25 26
  5. Recent advances in the treatment of pain. (PMID: 21173850) Davis M.P. (F1000 Med Rep 2010) 25 26

Products for ADRA2C Gene

Sources for ADRA2C Gene

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