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Aliases for ADRA2C Gene

Aliases for ADRA2C Gene

  • Adrenoceptor Alpha 2C 2 3
  • ADRA2L2 3 4 6
  • Alpha-2 Adrenergic Receptor Subtype C4 3 4
  • Adrenergic, Alpha-2C-, Receptor 2 3
  • Alpha-2C Adrenoreceptor 3 4
  • Alpha-2C Adrenoceptor 3 4
  • Alpha-2CAR 3 4
  • ADRA2RL2 3 4
  • Alpha-2C Adrenergic Receptor 3
  • Alpha-2C-Adrenergic Receptor 3
  • Alpha2-AR-C4 3
  • ADRARL2 3

External Ids for ADRA2C Gene

Previous HGNC Symbols for ADRA2C Gene

  • ADRA2L2
  • ADRA2RL2

Previous GeneCards Identifiers for ADRA2C Gene

  • GC04U990002
  • GC04M9J0040
  • GC04P003798

Summaries for ADRA2C Gene

Entrez Gene Summary for ADRA2C Gene

  • Alpha-2-adrenergic receptors are members of the G protein-coupled receptor superfamily. They include 3 highly homologous subtypes: alpha2A, alpha2B, and alpha2C. These receptors have a critical role in regulating neurotransmitter release from sympathetic nerves and from adrenergic neurons in the central nervous system. The mouse studies revealed that both the alpha2A and alpha2C subtypes were required for normal presynaptic control of transmitter release from sympathetic nerves in the heart and from central noradrenergic neurons. The alpha2A subtype inhibited transmitter release at high stimulation frequencies, whereas the alpha2C subtype modulated neurotransmission at lower levels of nerve activity. This gene encodes the alpha2C subtype, which contains no introns in either its coding or untranslated sequences. [provided by RefSeq, Jul 2008]

GeneCards Summary for ADRA2C Gene

ADRA2C (Adrenoceptor Alpha 2C) is a Protein Coding gene. Diseases associated with ADRA2C include orthostatic intolerance and congestive heart failure. Among its related pathways are Signaling by GPCR and Activation of cAMP-Dependent PKA. GO annotations related to this gene include protein homodimerization activity and alpha-2A adrenergic receptor binding. An important paralog of this gene is HTR1F.

UniProtKB/Swiss-Prot for ADRA2C Gene

  • Alpha-2 adrenergic receptors mediate the catecholamine-induced inhibition of adenylate cyclase through the action of G proteins

Tocris Summary for ADRA2C Gene

  • Adrenergic alpha2 receptors (alpha2-adrenoceptors) are members of the adrenergic receptor group of G-protein-coupled receptors that also includes alpha1A, alpha1B, alpha1D, beta1, beta2 and beta3. Adrenergic alpha2 receptors are divided into three subtypes: alpha2A, alpha2B and alpha2C, which are widely distributed in both the CNS and periphery. Alpha2-adrenoceptors play a role in the modulation of neurotransmission, smooth muscle contraction and thermoregulation. A fourth pharmacological subtype, alpha2D, has been identified in the rat which is thought to be a species ortholog of the human alpha2A subtype.

Gene Wiki entry for ADRA2C Gene

No data available for PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ADRA2C Gene

Genomics for ADRA2C Gene

Regulatory Elements for ADRA2C Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for ADRA2C Gene

3,766,348 bp from pter
3,768,526 bp from pter
2,179 bases
Plus strand

Genomic View for ADRA2C Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for ADRA2C Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ADRA2C Gene

Proteins for ADRA2C Gene

  • Protein details for ADRA2C Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Alpha-2C adrenergic receptor
    Protein Accession:
    Secondary Accessions:
    • P35369
    • Q9HB49

    Protein attributes for ADRA2C Gene

    462 amino acids
    Molecular mass:
    49522 Da
    Quaternary structure:
    No Data Available
    • Sequence=AAA35513.1; Type=Frameshift; Positions=270, 296, 300; Evidence={ECO:0000305}; Sequence=AAC78723.1; Type=Frameshift; Positions=270, 296, 300; Evidence={ECO:0000305};

neXtProt entry for ADRA2C Gene

Proteomics data for ADRA2C Gene at MOPED

Post-translational modifications for ADRA2C Gene

  • Glycosylation at Asn19 and Asn33
  • Modification sites at PhosphoSitePlus

Other Protein References for ADRA2C Gene

ENSEMBL proteins:
Reactome Protein details:
REFSEQ proteins:

Antibody Products

No data available for DME Specific Peptides for ADRA2C Gene

Domains for ADRA2C Gene

Gene Families for ADRA2C Gene

  • ADRA :GPCR / Class A : Adrenoceptors : alpha

Suggested Antigen Peptide Sequences for ADRA2C Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • P18825
  • Belongs to the G-protein coupled receptor 1 family. Adrenergic receptor subfamily. ADRA2C sub-subfamily.
genes like me logo Genes that share domains with ADRA2C: view

Function for ADRA2C Gene

Molecular function for ADRA2C Gene

GENATLAS Biochemistry:
adrenergic,alpha-2C-,receptor,G protein coupled receptor superfamily,without action on ion channels
UniProtKB/Swiss-Prot Function:
Alpha-2 adrenergic receptors mediate the catecholamine-induced inhibition of adenylate cyclase through the action of G proteins

Gene Ontology (GO) - Molecular Function for ADRA2C Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004930 G-protein coupled receptor activity --
GO:0004938 alpha2-adrenergic receptor activity IDA 17215105
GO:0005515 protein binding IPI 16531006
GO:0031694 alpha-2A adrenergic receptor binding IPI 16605244
GO:0042803 protein homodimerization activity IDA 16605244
genes like me logo Genes that share ontologies with ADRA2C: view
genes like me logo Genes that share phenotypes with ADRA2C: view

Animal Models for ADRA2C Gene

MGI Knock Outs for ADRA2C:

Animal Model Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for ADRA2C

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , miRNA , Transcription Factor Targeting and HOMER Transcription for ADRA2C Gene

Localization for ADRA2C Gene

Subcellular locations from UniProtKB/Swiss-Prot for ADRA2C Gene

Cell membrane; Multi-pass membrane protein.

Subcellular locations from

Jensen Localization Image for ADRA2C Gene COMPARTMENTS Subcellular localization image for ADRA2C gene
Compartment Confidence
plasma membrane 5
endosome 4
nucleus 1

Gene Ontology (GO) - Cellular Components for ADRA2C Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm IDA 16605244
GO:0005768 endosome TAS 10196213
GO:0005886 plasma membrane TAS --
GO:0005887 integral component of plasma membrane IDA 16605244
GO:0016021 integral component of membrane --
genes like me logo Genes that share ontologies with ADRA2C: view

Pathways for ADRA2C Gene

genes like me logo Genes that share pathways with ADRA2C: view

Pathways by source for ADRA2C Gene

PCR Array Products

  • Pathway & Disease-focused RT² Profiler PCR Arrays

Gene Ontology (GO) - Biological Process for ADRA2C Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006112 energy reserve metabolic process TAS --
GO:0006940 regulation of smooth muscle contraction --
GO:0007186 G-protein coupled receptor signaling pathway TAS 9371698
GO:0007267 cell-cell signaling TAS 9371698
GO:0007565 female pregnancy IEA --
genes like me logo Genes that share ontologies with ADRA2C: view

Compounds for ADRA2C Gene

(5) Tocris Compounds for ADRA2C Gene

Compound Action Cas Number
Atipamezole hydrochloride Selective alpha2 antagonist [104075-48-1]
BRL 44408 maleate Selective alpha2A antagonist [681806-46-2]
Dexmedetomidine hydrochloride Potent, highly selective alpha2 agonist. Active isomer of medetomidine (Cat. No. 2023) [145108-58-3]
Imiloxan hydrochloride Highly selective alpha2B antagonist [81167-22-8]
Yohimbine hydrochloride Selective alpha2 antagonist [65-19-0]

(54) ApexBio Compounds for ADRA2C Gene

Compound Action Cas Number
Acebutolol HCl [34381-68-5]
Adrenalone HCl [62-13-5]
Alfuzosin HCl "α1 adrenoceptor antagonist,functionally uro-selective" [81403-68-1]
Bambuterol [81732-65-2]
Betaxolol βadrenergic receptor blocker [659-18-7]
Betaxolol HCl [63659-19-8]
Bisoprolol fumarate [104344-23-2]
Carvedilol [72956-09-3]
Cisatracurium Besylate Neuromuscular-blocking drug [96946-42-8]
Clonidine HCl [4205-91-8]
Detomidine HCl [90038-01-0]
Dexmedetomidine [113775-47-6]
Dexmedetomidine HCl [145108-58-3]
DL-Adrenaline [329-65-7]
Doxazosin Mesylate α1-adrenergic receptor antagonist [77883-43-3]
Epinephrine Bitartrate [51-42-3]
Epinephrine HCl [55-31-2]
Formoterol Hemifumarate [43229-80-7]
Guanabenz Acetate [23256-50-0]
Indacaterol Maleate [753498-25-8]
Isoprenaline HCl [51-30-9]
Ivabradine HCl [148849-67-6]
Labetalol HCl [32780-64-6]
L-Adrenaline [51-43-4]
Lurasidone HCl Dopamine D2/5-HT2A/5-HT7/5-HT1A inhibitor [367514-88-3]
Maprotiline HCl [10347-81-6]
Medetomidine HCl [86347-15-1]
Methyldopa [555-30-6]
Metoprolol Tartrate β1-adrenergic blocking agent [392-17-7]
Mirabegron (YM178) [223673-61-8]
Naftopidil α1-adrenergic receptor antagonist [57149-07-2]
Naftopidil DiHCl [57149-08-3]
Naphazoline HCl [550-99-2]
Nebivolol [152520-56-4]
Nedaplatin [95734-82-0]
Oxymetazoline HCl Alpha-1/alpha-2 agonist [2315-2-8]
Phenoxybenzamine HCl [63-92-3]
Phentolamine Mesylate Alpha 1/2-blocking agent [65-28-1]
Phenylephrine HCl [61-76-7]
Prazosin HCl α1 and α2B-adrenoceptor antagonist [19237-84-4]
Propranolol HCl [318-98-9]
Ritodrine HCl β-2 adrenergic receptor agonist [23239-51-2]
Salbutamol Sulfate β-2 adrenergic receptor agonist [51022-70-9]
Salmeterol xinafoate β2-adrenergic receptor agonist [94749-08-3]
Scopine [498-45-3]
Silodosin α1-adrenoceptor antagonist [160970-54-7]
Synephrine HCl [5985-28-4]
Terazosin HCl [70024-40-7]
Terbutaline Sulfate [23031-32-5]
Tetrahydrozoline HCl [522-48-5]
Timolol Maleate [26921-17-5]
Tizanidine HCl [64461-82-1]
Tolazoline HCl [59-97-2]
Xylazine HCl α2 Adrenoceptor agonist [23076-35-9]

(1) HMDB Compounds for ADRA2C Gene

Compound Synonyms Cas Number PubMed IDs
  • (-)-(R)-Norepinephrine

(33) Drugbank Compounds for ADRA2C Gene

Compound Synonyms Cas Number Type Actions PubMed IDs
306-60-5 target agonist
  • Apomorfin
41372-20-7 target agonist
  • OPC 31
129722-12-9 target antagonist other/unknown
65576-45-6 target antagonist
  • Betanidine
55-73-2 target agonist

(30) IUPHAR Ligand for ADRA2C Gene

Ligand Type Action Affinity Pubmed IDs
[3H]MK-912 Antagonist Antagonist 10.1
prazosin Antagonist Inverse agonist 9.9
WB 4101 Antagonist Antagonist 9.8
dexmedetomidine Agonist Full agonist 9.3
[3H]RX821002 Antagonist Antagonist 9.2
terguride Antagonist Antagonist 8.9
spiroxatrine Agonist Full agonist 8.8
RX821002 Antagonist Antagonist 8.7
roxindole Antagonist Antagonist 8.6
phentolamine Antagonist Antagonist 8.6
[3H]rauwolscine Antagonist Antagonist 8.4
rauwolscine Antagonist Antagonist 8.4
ARC-239 Antagonist Antagonist 8.4
clonidine Agonist Partial agonist 7.8
JP1302 Antagonist Antagonist 7.8
brimonidine Agonist Partial agonist 7.6
yohimbine Antagonist Antagonist 7.3
lisuride Agonist Partial agonist 7.2
piribedil Agonist Partial agonist 6.9
BRL 44408 Antagonist Antagonist 6.8
oxymetazoline Agonist Full agonist 6.8
cabergoline Agonist Full agonist 6.7
pergolide Agonist Full agonist 6.5
bromocriptine Agonist Partial agonist 6.2
guanfacine Agonist Partial agonist 6.2
(plusmn)-adrenaline Agonist Full agonist 6.2
(-)-noradrenaline Agonist Full agonist 6
xylazine Agonist Partial agonist 5.9
apomorphine Activator Activation 5.1
chlorpromazine Channel blocker None

(6) Novoseek inferred chemical compound relationships for ADRA2C Gene

Compound -log(P) Hits PubMed IDs
norepinephrine 59 5
yohimbine 54.9 2
forskolin 25.3 2
catecholamine 24.9 2
tyrosine 1.72 1

(2) PharmGKB related drug/compound annotations for ADRA2C Gene

Drug/compound Annotation
bucindolol CA
clonidine CA
genes like me logo Genes that share compounds with ADRA2C: view

Transcripts for ADRA2C Gene

mRNA/cDNA for ADRA2C Gene

(29) Selected AceView cDNA sequences:
(2) Additional mRNA sequences :
(1) REFSEQ mRNAs :
(2) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for ADRA2C Gene

Adrenoceptor alpha 2C:
Representative Sequences:

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for ADRA2C

Primer Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for ADRA2C Gene

No ASD Table

Relevant External Links for ADRA2C Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for ADRA2C Gene

mRNA expression in normal human tissues for ADRA2C Gene

mRNA differential expression in normal tissues according to GTEx for ADRA2C Gene

This gene is overexpressed in Artery - Aorta (8.2), Cervix - Endocervix (6.7), and Artery - Tibial (4.8).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, and MOPED for ADRA2C Gene

SOURCE GeneReport for Unigene cluster for ADRA2C Gene Hs.123022

genes like me logo Genes that share expressions with ADRA2C: view

In Situ Assay Products

No data available for Protein differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Expression partners for ADRA2C Gene

Orthologs for ADRA2C Gene

This gene was present in the common ancestor of animals.

Orthologs for ADRA2C Gene

Organism Taxonomy Gene Similarity Type Details
(Canis familiaris)
Mammalia ADRA2C 35
  • 89.71 (n)
  • 89.03 (a)
  • 90 (a)
(Mus musculus)
Mammalia Adra2c 35
  • 84.3 (n)
  • 89.06 (a)
Adra2c 16
Adra2c 36
  • 94 (a)
(Pan troglodytes)
Mammalia ADRA2C 35
  • 98.62 (n)
  • 98.71 (a)
  • 88 (a)
(Rattus norvegicus)
Mammalia Adra2c 35
  • 84.6 (n)
  • 88.62 (a)
(Monodelphis domestica)
Mammalia ADRA2C 36
  • 67 (a)
(Gallus gallus)
Aves ADRA2C 35
  • 72.07 (n)
  • 74.68 (a)
  • 69 (a)
(Anolis carolinensis)
Reptilia -- 36
  • 45 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia adra2c 35
  • 68.64 (n)
  • 72.04 (a)
African clawed frog
(Xenopus laevis)
Amphibia Xl.26396 35
(Danio rerio)
Actinopterygii -- 35
adra2c 35
  • 64.38 (n)
  • 68.07 (a)
adra2c 36
  • 63 (a)
fruit fly
(Drosophila melanogaster)
Insecta 5-HT7 37
  • 33 (a)
CG18208 37
  • 49 (a)
DopR2 37
  • 44 (a)
CG18208 36
  • 23 (a)
Oct-TyrR 36
  • 24 (a)
(Caenorhabditis elegans)
Secernentea sca-1 37
  • 31 (a)
ser-1 37
  • 31 (a)
octr-1 36
  • 30 (a)
ser-2 36
  • 30 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 28 (a)
Species with no ortholog for ADRA2C:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • cow (Bos Taurus)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for ADRA2C Gene

Gene Tree for ADRA2C (if available)
Gene Tree for ADRA2C (if available)

Paralogs for ADRA2C Gene

Paralogs for ADRA2C Gene

Selected SIMAP similar genes for ADRA2C Gene using alignment to 3 proteins:

genes like me logo Genes that share paralogs with ADRA2C: view

Variants for ADRA2C Gene

Polymorphic Variants from UniProtKB/Swiss-Prot for ADRA2C Gene

The Del322-325 variant has a significant loss of function. It is approximately 10 times more frequent in African-Americans compared with Caucasians (allele frequencies 0.381 versus 0.040)

Sequence variations from dbSNP and Humsavar for ADRA2C Gene

SNP ID Clin Chr 04 pos Sequence Context AA Info Type MAF
rs1133450 -- 3,767,808(+) CTTCA(G/T)CTACA reference, missense
rs1133452 -- 3,767,943(+) CCGGC(C/G)ATCCT missense, reference
rs1133453 -- 3,767,950(+) TCCTT(C/T)AAGCA synonymous-codon, reference
rs1800037 -- 3,767,719(+) CGCAA(C/G)GTGGC missense, reference
rs6816971 -- 3,765,620(+) GGGGA(A/G)GCGAA upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for ADRA2C Gene

Variant ID Type Subtype PubMed ID
dgv1566e1 CNV Complex 17122850
nsv878471 CNV Loss 21882294
dgv5438n71 CNV Loss 21882294
dgv5440n71 CNV Loss 21882294
dgv5441n71 CNV Loss 21882294
nsv519631 CNV Loss 19592680
nsv878509 CNV Loss 21882294
dgv854n67 CNV Gain 20364138
esv26274 CNV Loss 19812545

Relevant External Links for ADRA2C Gene

HapMap Linkage Disequilibrium report
Human Gene Mutation Database (HGMD)

Disorders for ADRA2C Gene

(1) University of Copenhagen DISEASES for ADRA2C Gene

(3) Novoseek inferred disease relationships for ADRA2C Gene

Disease -log(P) Hits PubMed IDs
raynauds phenomenon 72.7 1
attention-deficit hyperactivity disorder 43.1 2
heart failure 34.2 7

Relevant External Links for ADRA2C

Genetic Association Database (GAD)
Human Genome Epidemiology (HuGE) Navigator
genes like me logo Genes that share disorders with ADRA2C: view

No data available for OMIM , UniProtKB/Swiss-Prot and Genatlas for ADRA2C Gene

Publications for ADRA2C Gene

  1. Identification of an additional gene belonging to the alpha 2 adrenergic receptor family in the human genome by PCR. (PMID: 1849485) Chhajlani V. … Wikberg J.E.S. (FEBS Lett. 1991) 2 3 4 23
  2. A four amino acid deletion polymorphism in the third intracellular loop of the human alpha 2C-adrenergic receptor confers impaired coupling to multiple effectors. (PMID: 10801795) Small K.M. … Liggett S.B. (J. Biol. Chem. 2000) 3 4 23
  3. Synergistic polymorphisms of beta1- and alpha2C-adrenergic receptors and the risk of congestive heart failure. (PMID: 12374873) Small K.M. … Liggett S.B. (N. Engl. J. Med. 2002) 3 23 48
  4. Identification of a naturally occurring 21 bp deletion in alpha 2c noradrenergic receptor gene and cognitive correlates to antipsychotic treatment. (PMID: 15683753) De Luca V. … Kennedy J.L. (Pharmacol. Res. 2005) 3 23 48
  5. A screen of candidate genes and influence of beta2-adrenergic receptor genotypes in postural tachycardia syndrome. (PMID: 15946904) Nickander K.K. … Low P.A. (Auton Neurosci 2005) 3 23 48

Products for ADRA2C Gene

Sources for ADRA2C Gene

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