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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

ADRA2C Gene

protein-coding   GIFtS: 67
GCID: GC04P003804

Adrenoceptor Alpha 2C

(Previous names: adrenergic, alpha-2C-, receptor)
(Previous symbols: ADRA2L2, ADRA2RL2)
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(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
Adrenoceptor Alpha 2C1 2     ADRARL22
ADRA2L21 2 3 5     ALPHA2CAR2
ADRA2RL21 2 3     alpha-2CAR2
Adrenergic, Alpha-2C-, Receptor1 2     Alpha-2C Adrenergic Receptor2
Alpha-2 Adrenergic Receptor Subtype C42 3     Alpha-2C-Adrenergic Receptor2
Alpha-2C Adrenoceptor2 3     alpha2-AR-C42
Alpha-2C Adrenoreceptor2 3     Alpha-2CAR3

External Ids:    HGNC: 2831   Entrez Gene: 1522   Ensembl: ENSG000001841607   OMIM: 1042505   UniProtKB: P188253   

Export aliases for ADRA2C gene to outside databases

Previous GC identifers: GC04U990002 GC04M9J0040 GC04P003798


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for ADRA2C Gene:
Alpha-2-adrenergic receptors are members of the G protein-coupled receptor superfamily. They include 3 highly
homologous subtypes: alpha2A, alpha2B, and alpha2C. These receptors have a critical role in regulating
neurotransmitter release from sympathetic nerves and from adrenergic neurons in the central nervous system. The
mouse studies revealed that both the alpha2A and alpha2C subtypes were required for normal presynaptic control of
transmitter release from sympathetic nerves in the heart and from central noradrenergic neurons. The alpha2A
subtype inhibited transmitter release at high stimulation frequencies, whereas the alpha2C subtype modulated
neurotransmission at lower levels of nerve activity. This gene encodes the alpha2C subtype, which contains no
introns in either its coding or untranslated sequences. (provided by RefSeq, Jul 2008)

GeneCards Summary for ADRA2C Gene: 
ADRA2C (adrenoceptor alpha 2C) is a protein-coding gene. Diseases associated with ADRA2C include tako-tsubo cardiomyopathy, and orthostatic intolerance, and among its related super-pathways are Class A/1 (Rhodopsin-like receptors) and Adrenaline signalling through Alpha-2 adrenergic receptor. GO annotations related to this gene include alpha-2A adrenergic receptor binding and protein homodimerization activity. An important paralog of this gene is HTR2A.

UniProtKB/Swiss-Prot: ADA2C_HUMAN, P18825
Function: Alpha-2 adrenergic receptors mediate the catecholamine-induced inhibition of adenylate cyclase through
the action of G proteins

summary for ADRA2C Gene:
Adrenergic alpha2 receptors (alpha2-adrenoceptors) are members of the adrenergic receptor group of
G-protein-coupled receptors that also includes alpha1A, alpha1B, alpha1D, beta1, beta2 and beta3. Adrenergic
alpha2 receptors are divided into three subtypes: alpha2A, alpha2B and alpha2C, which are widely distributed
in both the CNS and periphery. Alpha2-adrenoceptors play a role in the modulation of neurotransmission,
smooth muscle contraction and thermoregulation. A fourth pharmacological subtype, alpha2D, has been
identified in the rat which is thought to be a species ortholog of the human alpha2A subtype.

Gene Wiki entry for ADRA2C (Alpha-2C adrenergic receptor) Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000004.11  NC_018915.2  NT_006051.18  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the ADRA2C gene promoter:
         Bach1   E2F-3a   E2F-4   E2F-5   STAT1beta   E2F-2   MEF-2A   E2F-1   E2F   aMEF-2   
         Other transcription factors

Browse SwitchGear Promoter luciferase reporter plasmids
   Search SABiosciences Chromatin IP Primers for ADRA2C

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat ADRA2C


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 4p16   Ensembl cytogenetic band:  4p16.3   HGNC cytogenetic band: 4p16.3

ADRA2C Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
ADRA2C gene location

GeneLoc information about chromosome 4         GeneLoc Exon Structure

GeneLoc location for GC04P003804:  view genomic region     (about GC identifiers)

Start:
3,768,075 bp from pter      End:
3,770,253 bp from pter
Size:
2,179 bases      Orientation:
plus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: ADA2C_HUMAN, P18825 (See protein sequence)
Recommended Name: Alpha-2C adrenergic receptor  
Size: 462 amino acids; 49522 Da
Subcellular location: Cell membrane; Multi-pass membrane protein
Sequence caution: Sequence=AAA35513.1; Type=Frameshift; Positions=270, 296, 300; Sequence=AAC78723.1;
Type=Frameshift; Positions=270, 296, 300;
Secondary accessions: P35369 Q9HB49

Explore the universe of human proteins at neXtProt for ADRA2C: NX_P18825

Explore proteomics data for ADRA2C at MOPED 

Post-translational modifications:

  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_P18825

  • ADRA2C Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    ADRA2C Protein Expression
    REFSEQ proteins: NP_000674.2  
    ENSEMBL proteins: 
     ENSP00000426268   ENSP00000386069  
    Reactome Protein details: P18825
    Human Recombinant Protein Products for ADRA2C: 
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    Novus Biologicals ADRA2C Lysate
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates 
    Browse ProSpec Recombinant Proteins
    Browse Proteins at Cloud-Clone Corp. 

    Gene Ontology (GO): 5/7 cellular component terms (GO ID links to tree view) (see all 7):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005737cytoplasm IDA16605244
    GO:0005768endosome TAS10196213
    GO:0005886plasma membrane TAS--
    GO:0005887integral to plasma membrane IDA16605244
    GO:0016021integral to membrane ----

    ADRA2C for ontologies           About GeneDecksing



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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    HGNC Gene Families: 
    ADRA: GPCR / Class A : Adrenoceptors : alpha

    IUPHAR Guide to PHARMACOLOGY protein family classification: α2C-adrenoceptor 
    Adrenoceptors

    4 InterPro protein domains:
     IPR017452 GPCR_Rhodpsn_7TM
     IPR002233 Adrnrgc_rcpt
     IPR000735 Adren_rcpt_A2C
     IPR000276 GPCR_Rhodpsn

    Graphical View of Domain Structure for InterPro Entry P18825

    ProtoNet protein and cluster: P18825

    2 Blocks protein domains:
    IPB000735 Alpha-2C adrenergic receptor signature
    IPB002233 Adrenergic receptor signature


    UniProtKB/Swiss-Prot: ADA2C_HUMAN, P18825
    Similarity: Belongs to the G-protein coupled receptor 1 family. Adrenergic receptor subfamily. ADRA2C
    sub-subfamily


    ADRA2C for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: ADA2C_HUMAN, P18825
    Function: Alpha-2 adrenergic receptors mediate the catecholamine-induced inhibition of adenylate cyclase through
    the action of G proteins

         Genatlas biochemistry entry for ADRA2C:
    adrenergic,alpha-2C-,receptor,G protein coupled receptor superfamily,without action on ion channels

         Gene Ontology (GO): 5/7 molecular function terms (GO ID links to tree view) (see all 7):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0004930G-protein coupled receptor activity ----
    GO:0004938alpha2-adrenergic receptor activity IDA17215105
    GO:0005515protein binding IPI16531006
    GO:0031694alpha-2A adrenergic receptor binding IPI16605244
    GO:0042803protein homodimerization activity IDA16605244
         
    ADRA2C for ontologies           About GeneDecksing


    Phenotypes:
         2 GenomeRNAi human phenotypes for ADRA2C:
     Decreased substrate adherent c  Increased HPV18 LCR reporter a 

         6 MGI mutant phenotypes (inferred from 1 allele(MGI details for Adra2c):
     behavior/neurological  cardiovascular system  embryogenesis  homeostasis/metabolism  mortality/aging 
     nervous system 

    ADRA2C for phenotypes           About GeneDecksing

    Animal Models:
         MGI mouse knock-out Adra2ctm1Gsb for ADRA2C

       inGenious Targeting Laboratory - Custom generated mouse model solutions for ADRA2C 
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       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for ADRA2C 
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    SwitchGear 3'UTR luciferase reporter plasmidADRA2C 3' UTR sequence
    Inhib. RNA
    Products:
        
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    Clone
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ADRA2C


    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section

    SuperPaths for ADRA2C About   (see all 13)                                                                                              See pathways by source

    SuperPathContained pathways About
    1Class A/1 (Rhodopsin-like receptors)
    Class A/1 (Rhodopsin-like receptors)0.71
    GPCRs, Class A Rhodopsin-like0.41
    GPCR ligand binding0.71
    Neuroactive ligand-receptor interaction0.37
    G alpha (i) signalling events0.46
    2Adrenoceptors
    Adrenoceptors0.33
    Sympathetic Nerve Pathway (Neuroeffector Junction)0.33
    Adrenaline signalling through Alpha-2 adrenergic receptor0.33
    3Monoamine GPCRs
    Monoamine GPCRs0.79
    Amine ligand-binding receptors0.79
    4Signaling by GPCR
    Signaling by GPCR0.90
    Signal Transduction0.55
    GPCR downstream signaling0.90
    5Activation of cAMP-Dependent PKA
    Activation of cAMP-Dependent PKA0.77
    Activation of PKA through GPCR0.71
    cAMP Pathway0.77

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    1 EMD Millipore Pathway for ADRA2C
        Development Alpha-2 adrenergic receptor activation of ERK

    4 Downloadable PowerPoint Slides of QIAGEN Pathway Central Maps for ADRA2C
        Activation of PKA through GPCR
    AMPK Enzyme Complex Pathway
    cAMP Pathway
    Activation of cAMP-Dependent PKA

    1 GeneGo (Thomson Reuters) Pathway for ADRA2C
        Development Alpha-2 adrenergic receptor activation of ERK

    2 BioSystems Pathways for ADRA2C
        GPCRs, Class A Rhodopsin-like
    Monoamine GPCRs

    5/17        Reactome Pathways for ADRA2C (see all 17)
        Metabolism
    Regulation of Insulin Secretion
    Adrenaline signalling through Alpha-2 adrenergic receptor
    G alpha (z) signalling events
    Signal Transduction

    1 PharmGKB Pathway for ADRA2C
        Sympathetic Nerve Pathway (Neuroeffector Junction)

    1         Kegg Pathway  (Kegg details for ADRA2C):
        Neuroactive ligand-receptor interaction


    ADRA2C for pathways           About GeneDecksing

    Interactions:

        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for ADRA2C

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    5/151 Interacting proteins for ADRA2C (P188253 ENSP000003860694) via UniProtKB, MINT, STRING, and/or I2D (see all 151)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    GNAO1P094713, ENSP000002624934I2D: score=1 STRING: ENSP00000262493
    YWHAZP631043, ENSP000003095034I2D: score=2 STRING: ENSP00000309503
    EIF2B1Q142323I2D: score=3 
    PPP1R9BQ96SB33I2D: score=2 
    ADCY2ENSP000003429524STRING: ENSP00000342952
    About this table

    Gene Ontology (GO): 5/17 biological process terms (GO ID links to tree view) (see all 17):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006112energy reserve metabolic process TAS--
    GO:0007186G-protein coupled receptor signaling pathway TAS9371698
    GO:0007267cell-cell signaling TAS9371698
    GO:0007565female pregnancy IEA--
    GO:0007596blood coagulation TAS--

    ADRA2C for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section

    ADRA2C for compounds           About GeneDecksing

    Browse Small Molecules at EMD Millipore
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    Compounds for ADRA2C available from Tocris Bioscience    About this table
    CompoundAction CAS #
    JP 1302 dihydrochloridePotent and selective alpha2C antagonist[80259-18-3]
    BRL 44408 maleateSelective alpha2A antagonist[118343-19-4]
    Atipamezole hydrochlorideSelective alpha2 antagonist[104075-48-1]
    Medetomidine hydrochloride Potent, highly selective alpha2 agonist [106807-72-1]
    Dexmedetomidine hydrochloride Potent, highly selective alpha2 agonist. Active isomer of medetomidine (Cat. No. 2023) [145108-58-3]

    1 HMDB Compound for ADRA2C    About this table
    CompoundSynonyms CAS #PubMed Ids
    Norepinephrine(-)-(R)-Norepinephrine (see all 32)51-41-2--

    10/33 DrugBank Compounds for ADRA2C (see all 33)    About this table
    CompoundSynonyms CAS #TypeActionsPubMed Ids
    NorepinephrineArterenol (see all 4)51-41-2targetagonist1654268 18064417 17410123 1980236 17139284 8590979 17016423
    Yohimbine-- 146-48-5targetantagonist12438517 10611634 16176444 11226402 12591093 12110610
    BethanidineBetanidine (see all 2)55-73-2targetagonist1962798 17139284 17016423 2545383
    BrimonidineBrimonidine tartrate (see all 2)59803-98-4targetagonist11606316 16757535 12670699 14610637
    BromocriptineBromergocryptine (see all 10)25614-03-3targetagonist10641988 18691132 20138024
    CabergolineCabergolina [Spanish] (see all 2)81409-90-7targetantagonist10641988 18691132 12388667
    DroxidopaDroxydopa (see all 4)23651-95-8targetagonist18680204 21173850 8590979
    EphedraChinese jointfir (see all 3)--targetagonist12954796 14570629 15955613
    FenoldopamFenodopam mesylate (see all 3)67227-57-0targetantagonist17139284 7670737 17016423
    Methotrimeprazine-- 60-99-1targetantagonist2870716 6149771 15701205

    10/30 IUPHAR Ligands for ADRA2C2C-adrenoceptor) (see all 30)    About this table 
    LigandTypeActionAffinityPubmed IDs
    [3H]MK-912
    AntagonistAntagonist10.17996470
    lisuride
    AntagonistAntagonist9.912388666
    [3H]rauwolscine
    AntagonistAntagonist9.98819505 1353247
    yohimbine
    AntagonistAntagonist8.5 - 9.57908642 7996470 1353247
    WB 4101
    AntagonistAntagonist8.4 - 9.47908642 7996470 1353247
    dexmedetomidine
    AgonistFull agonist7 - 9.39605427 9760042 9824686
    [3H]RX821002
    AntagonistAntagonist8.2 - 9.27908642 8819505
    rauwolscine
    AntagonistAntagonist9.17996470
    terguride
    AntagonistAntagonist9.112388666
    spiroxatrine
    AntagonistAntagonist97996470

    6 Novoseek inferred chemical compound relationships for ADRA2C gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    norepinephrine 59 6 15946904 (1), 18947427 (1), 10334470 (1), 16188498 (1) (see all 5)
    yohimbine 54.9 2 16873606 (1), 15911252 (1)
    forskolin 25.3 2 18487435 (1), 10999953 (1)
    catecholamine 24.9 2 17075692 (1), 17643402 (1)
    tyrosine 1.72 2 19037602 (1)
    dopamine 0 2 10334470 (1)

    1 PharmGKB related drug/compound annotation for ADRA2C gene    About this table
    Drug/compound PharmGKB Annotation
    bucindololCA  

    Search CenterWatch for drugs/clinical trials and news about ADRA2C / ADA2C

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for ADRA2C gene: 
    NM_000683.3  

    Unigene Cluster for ADRA2C:

    Adrenoceptor alpha 2C
    Hs.123022  [show with all ESTs]
    Unigene Representative Sequence: BC142625
    2 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000509482 ENST00000330055(uc003ghm.3)

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    SwitchGear 3'UTR luciferase reporter plasmidADRA2C 3' UTR sequence
    Inhib. RNA
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      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat ADRA2C
      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat ADRA2C

    Additional mRNA sequence: 

    BC142625.1 J03853.1 

    2 DOTS entries:

    DT.206046  DT.121235832 

    24/29 AceView cDNA sequences (see all 29):

    AI492607 CR590957 CD673805 AW072770 AA458485 BG830756 T39448 BU538114 
    AL544609 BU539106 J03853 CB215653 AI831889 AI539550 BM987577 T40595 
    AL549866 AA936098 BU538113 AL530417 AA010313 CB217117 NM_000683 AL573897 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    ADRA2C expression in normal human tissues (normalized intensities)      ADRA2C embryonic expression: see
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: GGCGTGTTCG
    ADRA2C Expression
    About this image


    ADRA2C expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database 
     5/3 selected tissues (see all 3) fully expand
     
     Brain (Nervous System)    fully expand to see all 17 entries
             Thalamus
             striatum   
     
     Spinal Cord (Nervous System)    fully expand to see all 2 entries
             Dorsal Horn   
     
     Gut Tube (Gastrointestinal Tract)
             Definitive endoderm-like cells ( A scalable, suspension protocol for derivation of...

    See ADRA2C Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for ADRA2C

    SOURCE GeneReport for Unigene cluster: Hs.123022
        SABiosciences Expression via Pathway-Focused PCR Array including ADRA2C: 
              G Protein Coupled Receptors 384HT in human mouse rat

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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ADRA2C

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of animals.

    Orthologs for ADRA2C gene from 7/12 species (see all 12)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Adra2c1 , 5 adrenergic receptor, alpha 2c1, 5 87.99(n)1
    93.67(a)1
      5 (18.09 cM)5
    115531  NM_007418.31  NP_031444.21 
     352785665 
    chicken
    (Gallus gallus)
    Aves ADRA2C1 adrenergic, alpha-2C-, receptor 72.56(n)
    76.41(a)
      428799  XM_426355.3  XP_426355.3 
    lizard
    (Anolis carolinensis)
    Reptilia ADRA2C6
    adrenoceptor alpha 2C
    43(a)
    1 ↔ 1
    2(145952828-145954135)
    African clawed frog
    (Xenopus laevis)
    Amphibia Xl.263962 Xenopus laevis transcribed sequence with moderate similarity more 77.72(n)    CD361190.1 
    zebrafish
    (Danio rerio)
    Actinopterygii NM_194364.12   -- 81.15(n)   266754  NM_194364.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta CG182083   -- 49(a)
    (best of 3)
        --
    worm
    (Caenorhabditis elegans)
    Secernentea sca-13
    ser-31
    E1-E2 ATPases3
    Protein SER-31
    31(a)
    (best of 2)3
    40.9(n)1
    34.3(a)1
      X(16610545-16618262)3
    2597441  NM_059553.31  NP_491954.11 


    ENSEMBL Gene Tree for ADRA2C (if available)
    TreeFam Gene Tree for ADRA2C (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for ADRA2C gene
    HTR2A2  DRD42  HTR1A2  DRD22  HTR1F2  HTR72  HTR2B2  HTR2C2  
    ADRA2A2  HTR1D2  ADRA2B2  DRD32  HTR1E2  HTR5A2  HTR1B2  
    18 SIMAP similar genes for ADRA2C using alignment to 3 protein entries:     ADA2C_HUMAN (see all proteins):
    ADORA2A    ADRA2A    ADRA2B    HTR2A    HTR2B    HTR2C
    ADRA1A    GHSR    ADRB2    DRD2    5HT1A    HTR1A
    DRD5P1    CCR5    GPR85    HTR1D    HTR1F    HRH3

    ADRA2C for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    UniProtKB/Swiss-Prot: ADA2C_HUMAN, P18825
    Polymorphism: The Del322-325 variant has a significant loss of function. It is approximately 10 times more
    frequent in African-Americans compared with Caucasians (allele frequencies 0.381 versus 0.040)


    10/83 SNPs in ADRA2C are shown (see all 83)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 4 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs779621191,2
    F--3767136(+) GCCGGG/CGTGGG 1 -- us2k11Minor allele frequency- C:0.04WA 118
    rs1820961611,2
    C--3767369(+) TCTTAC/GAAAGA 1 -- us2k10--------
    rs97144311,2
    C,F,H--3767394(+) TCACCG/ACCCAG 1 -- us2k117Minor allele frequency- A:0.17NS EA NA CSA 2091
    rs614641941,2
    F--3767821(+) GCGCGC/TGGCGG 1 -- us2k11Minor allele frequency- T:0.19--382
    rs1123515021,2
    C--3767996(+) GCTCGC/ACGCCG 1 -- us2k11Minor allele frequency- A:0.00NA 2
    rs1389483591,2
    --3768104(+) CCTCCC/TGCTCT 1 -- us2k10--------
    rs1867496621,2
    --3768172(+) CCCGCA/GGAGCC 1 -- us2k10--------
    rs1903360611,2
    --3768371(+) GGTGGC/GGGCAG 2 A G mis10--------
    rs1463703851,2
    C--3768645(+) CTGGTA/CATGCC 2 V syn10--------
    rs1384575041,2
    C--3768741(+) TGCACC/GTCGTC 2 T syn10--------

    HapMap Linkage Disequilibrium report for ADRA2C (3768075 - 3770253 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 9 variations for ADRA2C:    About this table     
    Variant IDTypeSubtypePubMed ID
    dgv5441n71CNV Loss21882294
    nsv519631CNV Loss19592680
    dgv5438n71CNV Loss21882294
    dgv5440n71CNV Loss21882294
    nsv878509CNV Loss21882294
    nsv878471CNV Loss21882294
    esv26274CNV Loss19812545
    dgv854n67CNV Gain20364138
    dgv1566e1CNV Complex17122850


    Human Gene Mutation Database (HGMD): ADRA2C
    SABiosciences Cancer Mutation PCR Assays
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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    OMIM gene information: 104250    OMIM disorders: --

    20/25 diseases for ADRA2C (see all 25):    About MalaCards
    tako-tsubo cardiomyopathy    orthostatic intolerance    irritable bowel syndrome    congestive heart failure
    learning disability    dyspepsia    conduct disorder    attention deficit hyperactivity disorder
    neurologic diseases    long qt syndrome    mood disorder    scleroderma
    dilated cardiomyopathy    blindness    pheochromocytoma    neuronitis
    dementia    diabetes mellitus    parkinson's disease    myocardial infarction

    1 disease from the University of Copenhagen DISEASES database for ADRA2C:
    Attention deficit hyperactivity disorder

    ADRA2C for disorders           About GeneDecksing


    Congresses - knowledge worth sharing:  
    Alzheimer's & Parkinson's Diseases Congress (ADPD) 18 - 22 March 2015

    3 Novoseek inferred disease relationships for ADRA2C gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    raynauds phenomenon 72.7 1 15593189 (1)
    attention-deficit hyperactivity disorder 43.1 2 10334470 (1), 18835330 (1)
    heart failure 34.2 7 19880803 (2), 17643402 (1), 12374873 (1), 18320080 (1) (see all 6)

    Genetic Association Database (GAD): ADRA2C
    Human Genome Epidemiology (HuGE) Navigator: ADRA2C (48 documents)

    Export disorders for ADRA2C gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for ADRA2C gene, integrated from 9 sources (see all 164):
    (articles sorted by number of sources associating them with ADRA2C)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Identification of an additional gene belonging to the alpha 2 adrenergic receptor family in the human genome by PCR. (PubMed id 1849485)1, 2, 3, 9 Chhajlani V.... Wikberg J.E.S. (1991)
    2. Association between the alpha-2C-adrenergic receptor gene and attention deficit hyperactivity disorder in a Korean sample. (PubMed id 18835330)1, 4, 9 Cho S.C....Park T.W. (2008)
    3. Do allelic variants in alpha2A and alpha2C adrenergic receptors predispose to hypertension in blacks? (PubMed id 16636200)1, 4, 9 Li J.L....Victor R.G. (2006)
    4. An alpha2C-adrenergic receptor polymorphism alters th e norepinephrine-lowering effects and therapeutic response of the beta-blocker bucindolol in chronic heart failure. (PubMed id 19880803)1, 4, 9 Bristow M.R....Liggett S.B. (2010)
    5. Alpha-adrenoceptor gene variants and autonomic nervous system function in a young healthy Japanese population. (PubMed id 17075692)1, 4, 9 Matsunaga T....Tsuda K. (2007)
    6. Effect of the alpha2C-adrenoreceptor deletion322-325 variant on sympathetic activity and cardiovascular measures in healthy subjects. (PubMed id 17351367)1, 4, 9 Kurnik D....Stein C.M. (2007)
    7. Identification of a naturally occurring 21 bp deletion in alpha 2c noradrenergic receptor gene and cognitive correlates to antipsychotic treatment. (PubMed id 15683753)1, 4, 9 De Luca V....Kennedy J.L. (2005)
    8. A screen of candidate genes and influence of beta2-adrenergic receptor genotypes in postural tachycardia syndrome. (PubMed id 15946904)1, 4, 9 Nickander K.K....Low P.A. (2005)
    9. Synergistic polymorphisms of beta1- and alpha2C-adrenergic receptors and the risk of congestive heart failure. (PubMed id 12374873)1, 4, 9 Small K.M....Liggett S.B. (2002)
    10. The alpha2C-adrenoceptor deletion322-325 variant and cold-induced vasoconstriction. (PubMed id 19444546)1, 4, 9 Friedman E.A....Kurnik D. (2009)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 152 HGNC: 283 AceView: ADRA2C Ensembl:ENSG00000184160 euGenes: HUgn152
    ECgene: ADRA2C Kegg: 152 H-InvDB: ADRA2C

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for ADRA2C Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for ADRA2C gene:
    Search GeneIP for patents involving ADRA2C

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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