Free for academic non-profit institutions. Other users need a Commercial license

Aliases for ADRA2B Gene

Aliases for ADRA2B Gene

  • Adrenoceptor Alpha 2B 2 3 5
  • Alpha-2 Adrenergic Receptor Subtype C2 3 4
  • Alpha-2B Adrenoreceptor 3 4
  • Alpha-2BAR 3 4
  • ADRA2RL1 3 4
  • ADRA2L1 3 4
  • ADRA2B Adrenergic, Alpha-2B-, Receptor 3
  • Alpha-2-Adrenergic Receptor-Like 1 3
  • Adrenergic, Alpha-2B-, Receptor 2
  • G-Protein Coupled Receptor 3
  • Alpha-2B Adrenoceptor 4
  • ALPHA2BAR 3
  • ADRARL1 3
  • FAME2 3

External Ids for ADRA2B Gene

Previous HGNC Symbols for ADRA2B Gene

  • ADRA2L1
  • ADRA2RL1

Previous GeneCards Identifiers for ADRA2B Gene

  • GC02M094650
  • GC02M095232
  • GC02M096246
  • GC02M096263
  • GC02M096200
  • GC02M096142
  • GC02M096778
  • GC02M090739

Summaries for ADRA2B Gene

Entrez Gene Summary for ADRA2B Gene

  • This intronless gene encodes a seven-pass transmembrane protein. This protein is a member of a subfamily of G protein-coupled receptors that regulate neurotransmitter release from sympathetic nerves and from adrenergic neurons in the central nervous system. [provided by RefSeq, Apr 2014]

GeneCards Summary for ADRA2B Gene

ADRA2B (Adrenoceptor Alpha 2B) is a Protein Coding gene. Diseases associated with ADRA2B include epilepsy, myoclonic, familial adult, 2 and benign adult familial myoclonic epilepsy. Among its related pathways are cGMP-PKG signaling pathway and Peptide ligand-binding receptors. GO annotations related to this gene include G-protein coupled receptor activity and alpha2-adrenergic receptor activity. An important paralog of this gene is HTR1F.

UniProtKB/Swiss-Prot for ADRA2B Gene

  • Alpha-2 adrenergic receptors mediate the catecholamine-induced inhibition of adenylate cyclase through the action of G proteins. The rank order of potency for agonists of this receptor is clonidine > norepinephrine > epinephrine = oxymetazoline > dopamine > p-tyramine = phenylephrine > serotonin > p-synephrine / p-octopamine. For antagonists, the rank order is yohimbine > chlorpromazine > phentolamine > mianserine > spiperone > prazosin > alprenolol > propanolol > pindolol.

Tocris Summary for ADRA2B Gene

  • Adrenergic alpha2 receptors (alpha2-adrenoceptors) are members of the adrenergic receptor group of G-protein-coupled receptors that also includes alpha1A, alpha1B, alpha1D, beta1, beta2 and beta3. Adrenergic alpha2 receptors are divided into three subtypes in humans: alpha2A, alpha2B and alpha2C.

Gene Wiki entry for ADRA2B Gene

No data available for PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ADRA2B Gene

Genomics for ADRA2B Gene

Regulatory Elements for ADRA2B Gene

Enhancers for ADRA2B Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around ADRA2B on UCSC Golden Path with GeneCards custom track

Promoters for ADRA2B Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around ADRA2B on UCSC Golden Path with GeneCards custom track

Genomic Location for ADRA2B Gene

Chromosome:
2
Start:
96,112,875 bp from pter
End:
96,116,245 bp from pter
Size:
3,371 bases
Orientation:
Minus strand

Genomic View for ADRA2B Gene

Genes around ADRA2B on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ADRA2B Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ADRA2B Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ADRA2B Gene

Proteins for ADRA2B Gene

  • Protein details for ADRA2B Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P18089-ADA2B_HUMAN
    Recommended name:
    Alpha-2B adrenergic receptor
    Protein Accession:
    P18089
    Secondary Accessions:
    • Q4TUH9
    • Q53RF2
    • Q9BZK0

    Protein attributes for ADRA2B Gene

    Size:
    447 amino acids
    Molecular mass:
    49566 Da
    Quaternary structure:
    • Interacts with RAB26 (PubMed:23105096). Interacts with PPP1R9B (PubMed:24114805).

    Three dimensional structures from OCA and Proteopedia for ADRA2B Gene

neXtProt entry for ADRA2B Gene

Proteomics data for ADRA2B Gene at MOPED

Post-translational modifications for ADRA2B Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for ADRA2B Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for ADRA2B Gene

Domains & Families for ADRA2B Gene

Gene Families for ADRA2B Gene

Suggested Antigen Peptide Sequences for ADRA2B Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

P18089

UniProtKB/Swiss-Prot:

ADA2B_HUMAN :
  • Belongs to the G-protein coupled receptor 1 family. Adrenergic receptor subfamily. ADRA2B sub-subfamily.
Family:
  • Belongs to the G-protein coupled receptor 1 family. Adrenergic receptor subfamily. ADRA2B sub-subfamily.
genes like me logo Genes that share domains with ADRA2B: view

Function for ADRA2B Gene

Molecular function for ADRA2B Gene

GENATLAS Biochemistry:
adrenergic,alpha-2B-,receptor-like 1,G protein coupled receptor superfamily,inhibiting Ca2+ channels,contributing to the patho genesis of obesity
UniProtKB/Swiss-Prot Function:
Alpha-2 adrenergic receptors mediate the catecholamine-induced inhibition of adenylate cyclase through the action of G proteins. The rank order of potency for agonists of this receptor is clonidine > norepinephrine > epinephrine = oxymetazoline > dopamine > p-tyramine = phenylephrine > serotonin > p-synephrine / p-octopamine. For antagonists, the rank order is yohimbine > chlorpromazine > phentolamine > mianserine > spiperone > prazosin > alprenolol > propanolol > pindolol.
genes like me logo Genes that share phenotypes with ADRA2B: view

Human Phenotype Ontology for ADRA2B Gene

HPO Id HPO Name Alternative Ids Definition Synonyms

Animal Models for ADRA2B Gene

MGI Knock Outs for ADRA2B:

Animal Model Products

Inhibitory RNA Products

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Transcription Factor Targets and HOMER Transcription for ADRA2B Gene

Localization for ADRA2B Gene

Subcellular locations from UniProtKB/Swiss-Prot for ADRA2B Gene

Cell membrane; Multi-pass membrane protein. Note=Interaction with RAB26 mediates transport from the Golgi to the cell membrane.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for ADRA2B Gene COMPARTMENTS Subcellular localization image for ADRA2B gene
Compartment Confidence
plasma membrane 5
endoplasmic reticulum 1
nucleus 1

No data available for Gene Ontology (GO) - Cellular Components for ADRA2B Gene

Pathways & Interactions for ADRA2B Gene

genes like me logo Genes that share pathways with ADRA2B: view

Interacting Proteins for ADRA2B Gene

Gene Ontology (GO) - Biological Process for ADRA2B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003056 regulation of vascular smooth muscle contraction IEA --
GO:0006940 regulation of smooth muscle contraction IEA --
GO:0007186 G-protein coupled receptor signaling pathway IEA,TAS 2164221
GO:0007267 cell-cell signaling TAS 2164221
GO:0007565 female pregnancy IEA --
genes like me logo Genes that share ontologies with ADRA2B: view

No data available for SIGNOR curated interactions for ADRA2B Gene

Drugs & Compounds for ADRA2B Gene

(136) Drugs for ADRA2B Gene - From: DrugBank, ApexBio, DGIdb, IUPHAR, HMDB, Tocris, and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Yohimbine Approved Pharma Antagonist, antagonist, Target 25
Apomorphine Approved, Investigational Pharma Partial agonist, Agonist, agonist, Target 34
Brimonidine Approved Pharma Full agonist, Agonist, agonist, Target 0
Bromocriptine Approved, Investigational Pharma Antagonist, agonist, Target 29
Cabergoline Approved Pharma Antagonist, agonist, Target, antagonist 45

(9) Additional Compounds for ADRA2B Gene - From: HMDB, IUPHAR, Tocris, and Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
(plusmn)-adrenaline
Partial agonist, Agonist
p-Octopamine
  • (RS)-Octopamine
  • 1-(p-Hydroxyphenyl)-2-aminoethanol
  • 2-Amino-1-(4-hydroxyphenyl)ethanol
  • 4-Hydroxyphenethanolamine
  • 4-[2-Amino-1-hydroxyethyl]phenol
104-14-3
p-Synephrine
  • (+)-p-Synephrine
  • (+)-Synephrine
  • (+)-[(methylamino)methyl]-Benzenemethano
  • Analeptin
  • Oxedrine
94-07-5
Clonidine hydrochloride
4205-91-8
Guanfacine hydrochloride
29110-48-3

(5) Tocris Compounds for ADRA2B Gene

Compound Action Cas Number
Clonidine hydrochloride alpha2 agonist. Also I1 ligand 4205-91-8
Guanabenz acetate alpha2 agonist. Also I2 selective ligand 23256-50-0
Guanfacine hydrochloride alpha2A agonist 29110-48-3
Rilmenidine hemifumarate alpha2 agonist. Also I1 ligand 207572-68-7
UK 14,304 alpha2 agonist 59803-98-4

(57) ApexBio Compounds for ADRA2B Gene

Compound Action Cas Number
Acebutolol HCl 34381-68-5
Adrenalone HCl 62-13-5
Alfuzosin HCl α1 adrenoceptor antagonist,functionally uro-selective 81403-68-1
Bambuterol 81732-65-2
Betaxolol βadrenergic receptor blocker 659-18-7
Betaxolol HCl 63659-19-8
Bisoprolol fumarate 104344-23-2
Brimonidine Tartrate 70359-46-5
Carvedilol 72956-09-3
Cisatracurium Besylate Neuromuscular-blocking drug 96946-42-8
Clonidine HCl 4205-91-8
Detomidine HCl 90038-01-0
Dexmedetomidine 113775-47-6
Dexmedetomidine HCl 145108-58-3
DL-Adrenaline 329-65-7
Doxazosin Mesylate α1-adrenergic receptor antagonist 77883-43-3
Droxidopa 23651-95-8
Epinephrine Bitartrate 51-42-3
Epinephrine HCl 55-31-2
Formoterol Hemifumarate 43229-80-7
Guanabenz Acetate 23256-50-0
Indacaterol Maleate 753498-25-8
Isoprenaline HCl 51-30-9
Ivabradine HCl 148849-67-6
Labetalol HCl 32780-64-6
L-Adrenaline 51-43-4
Maprotiline HCl 10347-81-6
Medetomidine HCl 86347-15-1
Methyldopa 555-30-6
Metoprolol Tartrate β1-adrenergic blocking agent 392-17-7
Mirabegron (YM178) 223673-61-8
Naftopidil α1-adrenergic receptor antagonist 57149-07-2
Naftopidil DiHCl 57149-08-3
Naphazoline HCl 550-99-2
Nebivolol 152520-56-4
Nedaplatin 95734-82-0
Noradrenaline bitartrate monohydrate 108341-18-0
Oxymetazoline HCl Alpha-1/alpha-2 agonist 2315-02-8
Phenoxybenzamine HCl 63-92-3
Phentolamine Mesylate Alpha 1/2-blocking agent 65-28-1
Phenylephrine HCl 61-76-7
Prazosin HCl α1 and α2B-adrenoceptor antagonist 19237-84-4
Propranolol HCl 318-98-9
Ritodrine HCl β-2 adrenergic receptor agonist 23239-51-2
Salbutamol Sulfate β-2 adrenergic receptor agonist 51022-70-9
Salmeterol xinafoate β2-adrenergic receptor agonist 94749-08-3
Scopine 498-45-3
Silodosin α1-adrenoceptor antagonist 160970-54-7
Synephrine HCl 5985-28-4
Terazosin HCl 70024-40-7
Terbutaline Sulfate 23031-32-5
Tetrahydrozoline HCl 522-48-5
Timolol Maleate 26921-17-5
Tizanidine HCl 64461-82-1
Tolazoline HCl 59-97-2
Xylazine HCl α2 Adrenoceptor agonist 23076-35-9
Xylometazoline HCl 1218-35-5
genes like me logo Genes that share compounds with ADRA2B: view

Transcripts for ADRA2B Gene

mRNA/cDNA for ADRA2B Gene

(1) REFSEQ mRNAs :
(2) Additional mRNA sequences :
(8) Selected AceView cDNA sequences:
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for ADRA2B Gene

Adrenoceptor alpha 2B:
Representative Sequences:

Inhibitory RNA Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for ADRA2B Gene

No ASD Table

Relevant External Links for ADRA2B Gene

GeneLoc Exon Structure for
ADRA2B
ECgene alternative splicing isoforms for
ADRA2B

Expression for ADRA2B Gene

mRNA expression in normal human tissues for ADRA2B Gene

Protein differential expression in normal tissues from HIPED for ADRA2B Gene

This gene is overexpressed in Heart (69.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for ADRA2B Gene



SOURCE GeneReport for Unigene cluster for ADRA2B Gene Hs.247686

genes like me logo Genes that share expression patterns with ADRA2B: view

Protein tissue co-expression partners for ADRA2B Gene

Primer Products

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for ADRA2B Gene

Orthologs for ADRA2B Gene

This gene was present in the common ancestor of animals.

Orthologs for ADRA2B Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia ADRA2B 35
  • 87.72 (n)
  • 88.76 (a)
dog
(Canis familiaris)
Mammalia ADRA2B 35
  • 89.11 (n)
  • 90.77 (a)
mouse
(Mus musculus)
Mammalia Adra2b 35
  • 83.97 (n)
  • 83.45 (a)
Adra2b 16
chimpanzee
(Pan troglodytes)
Mammalia ADRA2B 35
  • 98.48 (n)
  • 97.32 (a)
rat
(Rattus norvegicus)
Mammalia Adra2b 35
  • 84.79 (n)
  • 84.79 (a)
chicken
(Gallus gallus)
Aves LOC101751513 35
  • 75.45 (n)
  • 73.03 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia adra2b 35
  • 60.48 (n)
  • 63.86 (a)
zebrafish
(Danio rerio)
Actinopterygii adra2b 35
  • 58.22 (n)
  • 57.08 (a)
fruit fly
(Drosophila melanogaster)
Insecta CG18208 37
  • 44 (a)
CG7431 37
  • 46 (a)
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP000606 35
  • 57.28 (n)
  • 45.16 (a)
worm
(Caenorhabditis elegans)
Secernentea dop-1 35
  • 47.49 (n)
  • 43.63 (a)
Species with no ortholog for ADRA2B:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for ADRA2B Gene

ENSEMBL:
Gene Tree for ADRA2B (if available)
TreeFam:
Gene Tree for ADRA2B (if available)

Paralogs for ADRA2B Gene

(6) SIMAP similar genes for ADRA2B Gene using alignment to 3 proteins:

genes like me logo Genes that share paralogs with ADRA2B: view

Variants for ADRA2B Gene

Polymorphic Variants from UniProtKB/Swiss-Prot for ADRA2B Gene

P18089-ADA2B_HUMAN
A rare polymorphic frameshift in position 448 produces a protein of 542 residues.

Sequence variations from dbSNP and Humsavar for ADRA2B Gene

SNP ID Clin Chr 02 pos Sequence Context AA Info Type
rs9333568 - 96,115,518(-) CAAGG(C/G/T)GGGGC reference, missense
VAR_025100 -
rs29000569 -, - 96,115,015(-) TTGGC(A/G)TTTTT reference, missense
rs2733969 -- 96,117,376(-) CCTGT(A/G)CACCG upstream-variant-2KB
rs2733970 -- 96,114,101(-) TGGGG(A/C)GGTCT utr-variant-3-prime

Structural Variations from Database of Genomic Variants (DGV) for ADRA2B Gene

Variant ID Type Subtype PubMed ID
dgv650e201 CNV Deletion 23290073
esv5003 CNV Complex 18987735
dgv4247n71 CNV Loss 21882294
dgv4248n71 CNV Loss 21882294
nsv874677 CNV Loss 21882294
nsv2834 CNV Loss 18451855
nsv874678 CNV Loss 21882294

Variation tolerance for ADRA2B Gene

Residual Variation Intolerance Score: 69.4% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.62; 31.12% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for ADRA2B Gene

HapMap Linkage Disequilibrium report
ADRA2B
Human Gene Mutation Database (HGMD)
ADRA2B

Disorders for ADRA2B Gene

MalaCards: The human disease database

(7) MalaCards diseases for ADRA2B Gene - From: OMIM, ClinVar, Orphanet, DISEASES, Novoseek, and GeneCards

Disorder Aliases PubMed IDs
epilepsy, myoclonic, familial adult, 2
  • epilepsy, myoclonic, adult familial, 2
benign adult familial myoclonic epilepsy
  • adcme
myoclonus
coronary restenosis
tremor
- elite association - COSMIC cancer census association via MalaCards

UniProtKB/Swiss-Prot

ADA2B_HUMAN
  • Epilepsy, familial adult myoclonic, 2 (FAME2) [MIM:607876]: A form of cortical myoclonic tremor with epilepsy, a syndrome characterized by cortical myoclonus and variable occurrence of epileptic seizures. Usually, myoclonic tremor is the presenting symptom, characterized by tremulous finger movements and myoclonic jerks of the limbs increased by action and posture. In a minority of patients, seizures are the presenting symptom; both complex partial as well as generalized tonic clonic seizures are described. Some patients exhibit mild cognitive impairment. {ECO:0000269 PubMed:24114805}. Note=The disease is caused by mutations affecting the gene represented in this entry.

Relevant External Links for ADRA2B

Genetic Association Database (GAD)
ADRA2B
Human Genome Epidemiology (HuGE) Navigator
ADRA2B
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
ADRA2B
genes like me logo Genes that share disorders with ADRA2B: view

No data available for Genatlas for ADRA2B Gene

Publications for ADRA2B Gene

  1. Expansion of the alpha 2-adrenergic receptor family: cloning and characterization of a human alpha 2-adrenergic receptor subtype, the gene for which is located on chromosome 2. (PMID: 2164221) Lomasney J.W. … Lefkowitz R.J. (Proc. Natl. Acad. Sci. U.S.A. 1990) 2 3 4 67
  2. Alpha-2B adrenergic receptor mediated hemodynamic profile of etomidate. (PMID: 20496522) Creagh O. … Gatica S.R. (P R Health Sci J 2010) 23 25 26
  3. Desensitization of vascular response in vivo: contribution of genetic variation in the [alpha]2B-adrenergic receptor subtype. (PMID: 20051907) Muszkat M. … Stein C.M. (J. Hypertens. 2010) 3 23
  4. Deletion variant of alpha2b-adrenergic receptor gene moderates the effect of COMT val(158)met polymorphism on episodic memory performance. (PMID: 20110158) Gibbs A.A. … David A.S. (Eur Neuropsychopharmacol 2010) 3 23
  5. Identification of a novel 12-nucleotide insertion polymorphism in the promoter region of ADRA2B: full linkage with the 9-nucleotide deletion in the coding region and influence on transcriptional activity. (PMID: 19728989) Crassous P.A. … Schaak S. (Biochem. Pharmacol. 2010) 3 23

Products for ADRA2B Gene

Sources for ADRA2B Gene

Content