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ADRA2B Gene

protein-coding   GIFtS: 63
GCID: GC02M096778

Adrenoceptor Alpha 2B

(Previous names: adrenergic, alpha-2B-, receptor)
(Previous symbols: ADRA2L1, ADRA2RL1)
  See ADRA2B-related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Adrenoceptor Alpha 2B1 2     ALPHA2BAR2
ADRA2L11 2 3 5     ADRA2B Adrenergic, Alpha-2B-, Receptor2
ADRA2RL11 2 3     Adrenergic Receptor Alpha 2B2
Adrenergic, Alpha-2B-, Receptor1 2     Alpha-2-Adrenergic Receptor-Like 12
Alpha-2 Adrenergic Receptor Subtype C22 3     alpha-2BAR2
Alpha-2B Adrenoceptor2 3     Alpha-2B Adrenergic Receptor2
Alpha-2B Adrenoreceptor2 3     G-Protein Coupled Receptor2
ADRARL12     Alpha-2BAR3

External Ids:    HGNC: 2821   Entrez Gene: 1512   Ensembl: ENSG000002220407   OMIM: 1042605   UniProtKB: P180893   

Export aliases for ADRA2B gene to outside databases

Previous GC identifers: GC02M094650 GC02M095232 GC02M096246 GC02M096263 GC02M096200 GC02M096142 GC02M090739


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for ADRA2B Gene:
Alpha-2-adrenergic receptors are members of the G protein-coupled receptor superfamily. They include 3 highly
homologous subtypes: alpha2A, alpha2B, and alpha2C. These receptors have a critical role in regulating
neurotransmitter release from sympathetic nerves and from adrenergic neurons in the central nervous system. This
intronless gene encodes the alpha2B subtype, which was observed to associate with eIF-2B, a guanine nucleotide
exchange protein that functions in regulation of translation. A polymorphic variant of the alpha2B subtype, which
lacks 3 glutamic acids from a glutamic acid repeat element, was identified to have decreased G protein-coupled
receptor kinase-mediated phosphorylation and desensitization; this polymorphic form is also associated with
reduced basal metabolic rate in obese subjects and may therefore contribute to the pathogenesis of obesity.
(provided by RefSeq, Aug 2011)

GeneCards Summary for ADRA2B Gene:
ADRA2B (adrenoceptor alpha 2B) is a protein-coding gene. Diseases associated with ADRA2B include coronary restenosis, and epilepsy, familial adult myoclonic, 5. GO annotations related to this gene include alpha2-adrenergic receptor activity and epinephrine binding. An important paralog of this gene is HTR1A.

UniProtKB/Swiss-Prot: ADA2B_HUMAN, P18089
Function: Alpha-2 adrenergic receptors mediate the catecholamine-induced inhibition of adenylate cyclase through
the action of G proteins. The rank order of potency for agonists of this receptor is clonidine > norepinephrine >
epinephrine = oxymetazoline > dopamine > p-tyramine = phenylephrine > serotonin > p-synephrine / p-octopamine.
For antagonists, the rank order is yohimbine > chlorpromazine > phentolamine > mianserine > spiperone > prazosin
> alprenolol > propanolol > pindolol

summary for ADRA2B Gene:
Adrenergic alpha2 receptors (alpha2-adrenoceptors) are members of the adrenergic receptor group of
G-protein-coupled receptors that also includes alpha1A, alpha1B, alpha1D, beta1, beta2 and beta3. Adrenergic
alpha2 receptors are divided into three subtypes: alpha2A, alpha2B and alpha2C, which are widely distributed
in both the CNS and periphery. Alpha2-adrenoceptors play a role in the modulation of neurotransmission,
smooth muscle contraction and thermoregulation. A fourth pharmacological subtype, alpha2D, has been
identified in the rat which is thought to be a species ortholog of the human alpha2A subtype.

Gene Wiki entry for ADRA2B (Alpha-2B adrenergic receptor) Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000002.11  NC_018913.2  NT_005403.18  
Regulatory elements:
   Regulatory transcription factor binding sites in the ADRA2B gene promoter:
         GR   Max1   GR-beta   NF-YB   CBF-A   CBF-B   CP1A   GR-alpha   c-Myc   CBF(2)   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidADRA2B promoter sequence
   Search Chromatin IP Primers for ADRA2B

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat ADRA2B


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 2q11.1   Ensembl cytogenetic band:  2q11.1   HGNC cytogenetic band: 2q11.1

ADRA2B Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
ADRA2B gene location

GeneLoc information about chromosome 2         GeneLoc Exon Structure

GeneLoc location for GC02M096778:  view genomic region     (about GC identifiers)

Start:
96,778,623 bp from pter      End:
96,781,984 bp from pter
Size:
3,362 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., eBioscience, and/or antibodies-online,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., eBioscience, and/or antibodies-online, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, Cloud-Clone Corp, antibodies-online, and/or others.)
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UniProtKB/Swiss-Prot: ADA2B_HUMAN, P18089 (See protein sequence)
Recommended Name: Alpha-2B adrenergic receptor  
Size: 450 amino acids; 49954 Da
Subunit: Interacts with RAB26
1 PDB 3D structure from and Proteopedia for ADRA2B:
2CVA (3D)    
Secondary accessions: Q4TUH9 Q53RF2 Q9BZK0

Explore the universe of human proteins at neXtProt for ADRA2B: NX_P18089

Explore proteomics data for ADRA2B at MOPED

Post-translational modifications: 

  • Modification sites at neXtProt
  • Modification sites at PhosphoSitePlus

  • See ADRA2B Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_000673.2  
    ENSEMBL proteins: 
     ENSP00000387281  
    Reactome Protein details: P18089

    ADRA2B Human Recombinant Protein Products:

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    Browse Proteins at Cloud-Clone Corp.

     
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    antibodies-online peptides for ADRA2B

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    antibodies-online kits for ADRA2B (12 products) 


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    ADRA: GPCR / Class A : Adrenoceptors : alpha

    IUPHAR Guide to PHARMACOLOGY protein family classification: alpha2B-adrenoceptor
    Adrenoceptors

    4 InterPro protein domains:
     IPR017452 GPCR_Rhodpsn_7TM
     IPR002233 ADR_fam
     IPR000276 GPCR_Rhodpsn
     IPR000207 ADRA2B_rcpt

    Graphical View of Domain Structure for InterPro Entry P18089

    ProtoNet protein and cluster: P18089

    2 Blocks protein domains:
    IPB000207 Alpha-2B adrenergic receptor signature
    IPB002233 Adrenergic receptor signature


    UniProtKB/Swiss-Prot: ADA2B_HUMAN, P18089
    Similarity: Belongs to the G-protein coupled receptor 1 family. Adrenergic receptor subfamily. ADRA2B
    sub-subfamily


    Find genes that share domains with ADRA2B           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: ADA2B_HUMAN, P18089
    Function: Alpha-2 adrenergic receptors mediate the catecholamine-induced inhibition of adenylate cyclase through
    the action of G proteins. The rank order of potency for agonists of this receptor is clonidine > norepinephrine >
    epinephrine = oxymetazoline > dopamine > p-tyramine = phenylephrine > serotonin > p-synephrine / p-octopamine.
    For antagonists, the rank order is yohimbine > chlorpromazine > phentolamine > mianserine > spiperone > prazosin
    > alprenolol > propanolol > pindolol

         Genatlas biochemistry entry for ADRA2B:
    adrenergic,alpha-2B-,receptor-like 1,G protein coupled receptor superfamily,inhibiting Ca2+ channels,contributing
    to the patho genesis of obesity

         Gene Ontology (GO): 5 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0004930G-protein coupled receptor activity ----
    GO:0004935adrenergic receptor activity ----
    GO:0004938alpha2-adrenergic receptor activity IDA17215105
    GO:0005515protein binding IPI16531006
    GO:0051379epinephrine binding IDA17215105
         
    Find genes that share ontologies with ADRA2B           About GenesLikeMe


    Phenotypes:
         1 GenomeRNAi human phenotype for ADRA2B:
     Decreased substrate adherent c 

         12 MGI mutant phenotypes (inferred from 1 allele(MGI details for Adra2b):
     behavior/neurological  cardiovascular system  cellular  embryogenesis  growth/size/body 
     hematopoietic system  homeostasis/metabolism  mortality/aging  muscle  renal/urinary system 
     reproductive system  respiratory system 

    Find genes that share phenotypes with ADRA2B           About GenesLikeMe

    Animal Models:
         MGI mouse knock-out Adra2btm1Gsb for ADRA2B

       genOway: Develop your customized and physiologically relevant rodent model for ADRA2B

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    hsa-miR-21* hsa-miR-30d hsa-miR-3074-3p hsa-miR-507 hsa-miR-3161 hsa-miR-30a hsa-miR-34b hsa-miR-330-3p
    SwitchGear 3'UTR luciferase reporter plasmidADRA2B 3' UTR sequence
    Inhib. RNA
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    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    ADA2B_HUMAN, P18089: Cell membrane; Multi-pass membrane protein. Note=Interaction with RAB26 mediates transport
    from the Golgi to the cell membrane
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    plasma membrane5
    endoplasmic reticulum1
    nucleus1

    Gene Ontology (GO): 3 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005886plasma membrane TAS--
    GO:0005887integral component of plasma membrane TAS2164221
    GO:0016021integral component of membrane ----

    Find genes that share ontologies with ADRA2B           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for ADRA2B About   (see all 11)  
    See pathways by source

    SuperPathContained pathways About
    1Peptide ligand-binding receptors
    Class A/1 (Rhodopsin-like receptors)0.71
    GPCRs, Class A Rhodopsin-like0.43
    GPCR ligand binding0.71
    Neuroactive ligand-receptor interaction0.36
    G alpha (i) signalling events0.44
    2Monoamine GPCRs
    Monoamine GPCRs0.79
    Adrenoceptors0.00
    Amine ligand-binding receptors0.79
    Adrenaline signalling through Alpha-2 adrenergic receptor0.00
    3Signaling by GPCR
    Signaling by GPCR0.90
    Signal Transduction0.58
    GPCR downstream signaling0.90
    4Activation of cAMP-Dependent PKA
    Activation of cAMP-Dependent PKA0.77
    Activation of PKA through GPCR0.71
    cAMP Pathway0.77
    5Hemostasis
    Hemostasis0.43
    Platelet activation, signaling and aggregation0.43


    Find genes that share SuperPaths with ADRA2B           About GenesLikeMe

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    5 Downloadable PowerPoint Slides of GeneGlobe Pathway Central Maps for ADRA2B
        Activation of PKA through GPCR
    AMPK Enzyme Complex Pathway
    cAMP Pathway
    Activation of cAMP-Dependent PKA
    Signaling Involved in Cardiac Hypertrophy

    1 GeneGo (Thomson Reuters) Pathway for ADRA2B
        Development Alpha-2 adrenergic receptor activation of ERK

    2 BioSystems Pathways for ADRA2B
        GPCRs, Class A Rhodopsin-like
    Monoamine GPCRs


    4 Reactome Pathways for ADRA2B
        G alpha (i) signalling events
    Adrenaline signalling through Alpha-2 adrenergic receptor
    Adrenoceptors
    G alpha (z) signalling events

    1 PharmGKB Pathway for ADRA2B
        Sympathetic Nerve Pathway (Neuroeffector Junction)

    1 Kegg Pathway  (Kegg details for ADRA2B):
        Neuroactive ligand-receptor interaction

        Pathway & Disease-focused RT2 Profiler PCR Arrays including ADRA2B: 
              G Protein Coupled Receptors 384HT in human mouse rat
              Obesity in human mouse rat

    Interactions:

        Search GeneGlobe Interaction Network for ADRA2B

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for ADRA2B (P180893 ENSP000003872814) via UniProtKB, MINT, STRING, and/or I2D (see all 151)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    GNAI2P048993, ENSP000003129994I2D: score=1 STRING: ENSP00000312999
    YWHAZP631043, ENSP000003095034I2D: score=1 STRING: ENSP00000309503
    EIF2B1Q142323I2D: score=3 
    PPP1R9BQ96SB33I2D: score=2 
    ADCY2ENSP000003429524STRING: ENSP00000342952
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 17):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000165MAPK cascade IEA--
    GO:0000187activation of MAPK activity ----
    GO:0001525angiogenesis IEA--
    GO:0003056regulation of vascular smooth muscle contraction IEA--
    GO:0007186G-protein coupled receptor signaling pathway TAS2164221

    Find genes that share ontologies with ADRA2B           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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      Browse compounds at ApexBio 

    Compounds for ADRA2B available from Tocris Bioscience    About this table
    CompoundAction CAS #
    JP 1302 dihydrochloridePotent and selective alpha2C antagonist[80259-18-3]
    BRL 44408 maleateSelective alpha2A antagonist[118343-19-4]
    Atipamezole hydrochlorideSelective alpha2 antagonist[104075-48-1]
    Medetomidine hydrochloride Potent, highly selective alpha2 agonist [106807-72-1]
    Dexmedetomidine hydrochloride Potent, highly selective alpha2 agonist. Active isomer of medetomidine (Cat. No. 2023) [145108-58-3]

    6 HMDB Compounds for ADRA2B    About this table
    CompoundSynonyms CAS #PubMed Ids
    Epinephrine(-)-(R)-Epinephrine (see all 72)51-43-4--
    Norepinephrine(-)-(R)-Norepinephrine (see all 32)51-41-2--
    PhenylephrineAdrianol (see all 60)59-42-7--
    Tyramine2-(4'-Hydroxyphenyl)ethylamine (see all 34)51-67-2--
    p-Octopamine(RS)-Octopamine (see all 17)104-14-3--
    p-Synephrine(+)-Synephrine (see all 3)532-80-9--

    Selected DrugBank Compounds for ADRA2B (see all 35)    About this table
    CompoundSynonyms CAS #TypeActionsPubMed Ids
    NorepinephrineArterenol (see all 4)51-41-2targetagonist18064417 1980236 17139284 11728431 11053214 17016423 1979424
    Yohimbine-- 146-48-5targetantagonist10611634 10822066 17123717 12110610 8872361 12170055
    EpinephrineADR Adrenaline (see all 25)51-43-4targetagonist18064417 1980236 11728431 11053214 1979424
    CabergolineCabergolina [Spanish] (see all 2)81409-90-7targetantagonist10641988 18691132 12388667 18992242
    BromocriptineBromergocryptine (see all 10)25614-03-3targetagonist10641988 18691132 20138024
    DroxidopaDroxydopa (see all 4)23651-95-8targetagonist18064417 18680204 21173850
    EphedraChinese jointfir (see all 3)--targetagonist12954796 14570629 15955613
    FenoldopamFenodopam mesylate (see all 3)67227-57-0targetantagonist17139284 7670737 17016423
    Methotrimeprazine-- 60-99-1targetantagonist2870716 6149771 15701205
    BethanidineBetanidine (see all 2)55-73-2targetagonist17139284 17016423

    Selected IUPHAR Ligands for ADRA2B (alpha2B-adrenoceptor) (see all 28)    About this table
    LigandTypeActionAffinityPubmed IDs
    lisuride
    AntagonistAntagonist9.912388666
    dexmedetomidine
    AgonistFull agonist7.5 - 9.79605427 9760042 9824686
    clonidine
    AgonistPartial agonist6.7 - 9.59605427 9760042 9824686
    terguride
    AntagonistAntagonist9.412388666
    [3H]rauwolscine
    AntagonistAntagonist9.48819505 1353247
    (-)-noradrenaline
    AgonistPartial agonist5.6 - 9.19605427 9760042 9824686
    [3H]RX821002
    AntagonistAntagonist8 - 9.17908642 8819505
    yohimbine
    AntagonistAntagonist7.9 - 8.97908642 7996470 1353247
    [3H]MK-912
    AntagonistAntagonist8.97996470
    spiroxatrine
    AntagonistAntagonist8.87996470

    7 Novoseek inferred chemical compound relationships for ADRA2B gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    yohimbine 50.4 4 15920038 (2)
    epinephrine 37 3 16533872 (2)
    nadh 17.1 3 11158372 (1), 12878463 (1)
    sucrose 3.69 1 8170959 (1)
    glutamate 0.372 1 10509541 (1)
    cholesterol 0 1 12401126 (1)
    glucose 0 1 15309292 (1)



    Find genes that share compounds with ADRA2B           About GenesLikeMe



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for ADRA2B gene: 
    NM_000682.5  

    Unigene Cluster for ADRA2B:

    Adrenoceptor alpha 2B
    Hs.247686  [show with all ESTs]
    Unigene Representative Sequence: NM_000682
    1 Ensembl transcript including schematic representation, and UCSC links where relevant:
    ENST00000409345(uc021vlh.1)
    miRNA
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    hsa-miR-21* hsa-miR-30d hsa-miR-3074-3p hsa-miR-507 hsa-miR-3161 hsa-miR-30a hsa-miR-34b hsa-miR-330-3p
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    eBioscience FlowRNA Probe Sets ( VA1-11947 VF1-11953) for ADRA2B 

    Additional mRNA sequence: 

    BC133021.1 BC136537.1 

    1 DOTS entry:

    DT.40128047 

    8 AceView cDNA sequences:

    NM_000682 AI791589 BF475329 BX111005 AI733093 AA887330 BQ880026 AW361747 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    ADRA2B expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: --
    ADRA2B Expression
    About this image

    ADRA2B Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    ADRA2B Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.247686
        Pathway & Disease-focused RT2 Profiler PCR Arrays including ADRA2B: 
              G Protein Coupled Receptors 384HT in human mouse rat
              Obesity in human mouse rat

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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ADRA2B

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of animals.

    Orthologs for ADRA2B gene from Selected species (see all 14)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Adra2b1 , 5 adrenergic receptor, alpha 2b1, 5 83.97(n)1
    83.45(a)1
      2 (61.95 cM)5
    115521  NM_009633.31  NP_033763.21 
     1273632085 
    chicken
    (Gallus gallus)
    Aves LOC1017515131 alpha-2B adrenergic receptor-like 75.45(n)
    73.03(a)
      101751513  XM_004950950.1  XP_004951007.1 
    lizard
    (Anolis carolinensis)
    Reptilia ADRA2B6
    adrenoceptor alpha 2B
    59(a)
    1 ↔ 1
    GL344471.1(20974-22974)
    tropical clawed frog
    (Xenopus tropicalis)
    Amphibia adra2b1 adrenoceptor alpha 2B 60.48(n)
    63.86(a)
      100485811  XM_002932564.2  XP_002932610.1 
    zebrafish
    (Danio rerio)
    Actinopterygii adra2b1 adrenergic, alpha-2B-, receptor 58.22(n)
    57.08(a)
      266751  NM_207638.1  NP_997521.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta CG74313 G-protein coupled receptor protein
    signaling pathway amine receptor less
    46(a)
    (best of 2)
        --
    worm
    (Caenorhabditis elegans)
    Secernentea dop-11 dop-1 47.49(n)
    43.63(a)
      180714  NM_001029408.1  NP_001024579.1 


    ENSEMBL Gene Tree for ADRA2B (if available)
    TreeFam Gene Tree for ADRA2B (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for ADRA2B gene
    HTR1A2  ADRA1B2  HTR1F2  HTR72  ADRA2C2  ADRA2A2  HTR1D2  ADRA1A2  
    HTR1E2  HTR5A2  HTR1B2  ADRA1D2  
    6 SIMAP similar genes for ADRA2B using alignment to 3 protein entries:     ADA2B_HUMAN (see all proteins):
    ADRA2A    ADRA2C    HRH3    DRD2    5HT1A    HTR1A

    Find genes that share paralogs with ADRA2B           About GenesLikeMe



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Polymorphic Variants from UniProtKB/Swiss-Prot
    ADA2B_HUMAN, P18089: A rare polymorphic frameshift in position 451 produces a protein of 542 residues


    Selected SNPs for ADRA2B (see all 153)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 2 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs22526971,2
    C,A--96436046(+) ACCCGC/GGGCTA 1 -- ds500112Minor allele frequency- G:0.35NS NA WA CSA EA 880
    rs1498195201,2
    --96436060(+) TGGGGA/CTGTTT 1 -- ds50010--------
    rs1923123281,2
    --96436131(+) AACACC/TCTCCC 1 -- ds50010--------
    rs1846476181,2
    --96436159(+) ACTCCC/TTCTCT 1 -- ds50010--------
    rs76086451,2
    C--96436206(+) AAAACC/TCTCCC 1 -- ds50010--------
    rs1402081881,2
    --96436310(+) GCGGGC/TAGGAA 1 -- ds50010--------
    rs1902261671,2
    --96436351(+) CATCTC/TGGGGA 1 -- ds50010--------
    rs347908071,2
    C--96436535(+) AAAAA-/A/CCACCA 2 -- ut311NA 2
    rs769466071,2
    C--96436536(+) AAAAAC/AACCAC 1 -- ut311Minor allele frequency- A:0.50NA 2
    rs1824072371,2
    --96436561(+) AAGAGA/GTCACA 1 -- ut310--------

    HapMap Linkage Disequilibrium report for ADRA2B (96778623 - 96781984 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 7 variations for ADRA2B:    About this table    
    Variant IDTypeSubtypePubMed ID
    dgv650e201CNV Deletion23290073
    dgv4247n71CNV Loss21882294
    nsv874678CNV Loss21882294
    nsv2834CNV Loss18451855
    dgv4248n71CNV Loss21882294
    nsv874677CNV Loss21882294
    esv5003CNV Complex18987735

    Human Gene Mutation Database (HGMD): ADRA2B
    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing ADRA2B
    DNA2.0 Custom Variant and Variant Library Synthesis for ADRA2B

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 104260    OMIM disorders: --

    8 diseases for ADRA2B:    
    About MalaCards
    coronary restenosis    epilepsy, familial adult myoclonic, 5    orthostatic intolerance    neurologic diseases
    morbid obesity    essential hypertension    type 2 diabetes mellitus    obesity


    Find genes that share disorders with ADRA2B           About GenesLikeMe

    5 Novoseek inferred disease relationships for ADRA2B gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    resting heart rate 45.4 2 16907703 (1)
    essential hypertension 26.7 1 10509541 (1)
    glioma 5.89 1 2169434 (1)
    myocardial infarction 0 1 12401126 (1)
    breast cancer 0 3 12878463 (1), 12270893 (1)

    Genetic Association Database (GAD): ADRA2B
    Human Genome Epidemiology (HuGE) Navigator: ADRA2B (55 documents)

    Export disorders for ADRA2B gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for ADRA2B gene, integrated from 10 sources (see all 179):
    (articles sorted by number of sources associating them with ADRA2B)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Expansion of the alpha 2-adrenergic receptor family: cloning and characterization of a human alpha 2-adrenergic receptor subtype, the gene for which is located on chromosome 2. (PubMed id 2164221)1, 2, 3 Lomasney J.W.... Lefkowitz R.J. (Proc. Natl. Acad. Sci. U.S.A. 1990)
    2. Variation in the alpha2B-adrenergic receptor gene (ADRA2B) and its relationship to vascular response in vivo. (PubMed id 15900214)1, 4, 9 Muszkat M....Stein C.M. (Pharmacogenet. Genomics 2005)
    3. Desensitization of vascular response in vivo: contribution of genetic variation in the [alpha]2B-adrenergic receptor subtype. (PubMed id 20051907)1, 4, 9 Muszkat M....Stein C.M. (J. Hypertens. 2010)
    4. Genetic variation at the human alpha2B-adrenergic receptor locus: role in blood pressure variation and yohimbine response. (PubMed id 15920038)1, 4, 9 Etzel J.P....Insel P.A. (Hypertension 2005)
    5. Deletion polymorphism in the alpha2B-adrenergic receptor gene is associated with flow-mediated dilatation of the brachial artery. (PubMed id 12401126)1, 4, 9 Heinonen P....Scheinin M. (Clin. Sci. 2002)
    6. Alpha2B-adrenergic receptor deletion polymorphism and cardiac autonomic nervous system responses to exercise in obese women. (PubMed id 16247508)1, 4, 9 Ueno L.M....NegrALo C.E. (Int J Obes (Lond) 2006)
    7. Chromosome 2q12, the ADRA2B I/D polymorphism and metabolic syndrome. (PubMed id 19593211)1, 4, 9 Fava C....Melander O. (J. Hypertens. 2009)
    8. Physical activity, diet, and incident diabetes in relation to an ADRA2B polymorphism. (PubMed id 17277585)1, 4, 9 Laaksonen D.E....Uusitupa M. (Med Sci Sports Exerc 2007)
    9. Job strain, decision latitude and alpha2B-adrenergic receptor polymorphism significantly interact, and associate with higher blood pressures in men. (PubMed id 17620957)1, 4, 9 Ohlin B....Melander O. (J. Hypertens. 2007)
    10. Human response to alpha2-adrenergic agonist stimulation studied in an isolated vascular bed in vivo: Biphasic influence of dose, age, gender, and receptor genotype. (PubMed id 15900285)1, 4, 9 King D....O'Connor D.T. (Clin. Pharmacol. Ther. 2005)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 151 HGNC: 282 AceView: ADRA2B Ensembl:ENSG00000222040 euGenes: HUgn151
    ECgene: ADRA2B Kegg: 151 H-InvDB: ADRA2B

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
    About This Section

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    NameDescription
    PharmGKB entry for ADRA2B Pharmacogenomics, SNPs, Pathways
    SeattleSNPshttp://pga.gs.washington.edu/data/adra2b/

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for ADRA2B gene:
    Search GeneIP for patents involving ADRA2B

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, eBioscience, antibodies-online, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
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