ADRA2B Gene
protein-coding GIFtS: 63
GCID: GC02M096778
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|
adrenoceptor alpha 2B(Previous names: adrenergic, alpha-2B-, receptor )
(Previous symbols: ADRA2L1, ADRA2RL1)
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Aliases
for ADRA2B gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| Adrenoceptor Alpha 2B1 2 | | ALPHA2BAR2 | | ADRA2L11 2 3 5 | | ADRA2B Adrenergic, Alpha-2B-, Receptor2 | | ADRA2RL11 2 3 | | Adrenergic Receptor Alpha 2B2 | | ADRARL11 2 | | Alpha-2-Adrenergic Receptor-Like 12 | | Adrenergic, Alpha-2B-, Receptor1 2 | | Alpha-2BAR3 | | Alpha-2 Adrenergic Receptor Subtype C22 3 | | Alpha-2B Adrenergic Receptor2 | | Alpha-2B Adrenoceptor2 3 | | G-Protein Coupled Receptor2 | | Alpha-2B Adrenoreceptor2 3 | | Alpha-2BAR3 |
Export aliases for ADRA2B gene to outside databasesPrevious GC identifers: GC02M094650 GC02M095232 GC02M096246 GC02M096263 GC02M096200 GC02M096142 GC02M090739 |
Summaries
for ADRA2B gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
Entrez Gene summary for ADRA2B:
Alpha-2-adrenergic receptors are members of the G protein-coupled receptor superfamily. They include 3 highlyhomologous subtypes: alpha2A, alpha2B, and alpha2C. These receptors have a critical role in regulatingneurotransmitter release from sympathetic nerves and from adrenergic neurons in the central nervous system. Thisintronless gene encodes the alpha2B subtype, which was observed to associate with eIF-2B, a guanine nucleotideexchange protein that functions in regulation of translation. A polymorphic variant of the alpha2B subtype, whichlacks 3 glutamic acids from a glutamic acid repeat element, was identified to have decreased G protein-coupledreceptor kinase-mediated phosphorylation and desensitization; this polymorphic form is also associated with reducedbasal metabolic rate in obese subjects and may therefore contribute to the pathogenesis of obesity. (provided byRefSeq, Aug 2011)
UniProtKB/Swiss-Prot: ADA2B_HUMAN, P18089Function: Alpha-2 adrenergic receptors mediate the catecholamine-induced inhibition of adenylate cyclase through theaction of G proteins. The rank order of potency for agonists of this receptor is clonidine > norepinephrine >epinephrine = oxymetazoline > dopamine > p-tyramine = phenylephrine > serotonin > p-synephrine / p-octopamine. Forantagonists, the rank order is yohimbine > chlorpromazine > phentolamine > mianserine > spiperone > prazosin >alprenolol > propanolol > pindolol
 summary
for ADRA2B: Adrenergic alpha2 receptors (alpha2-adrenoceptors) are members of the adrenergic receptor group of
G-protein-coupled receptors that also includes alpha1A, alpha1B, alpha1D, beta1, beta2 and beta3. Adrenergic
alpha2 receptors are divided into three subtypes: alpha2A, alpha2B and alpha2C, which are widely distributed
in both the CNS and periphery. Alpha2-adrenoceptors play a role in the modulation of neurotransmission,
smooth muscle contraction and thermoregulation. A fourth pharmacological subtype, alpha2D, has been
identified in the rat which is thought to be a species ortholog of the human alpha2A subtype.
Gene Wiki entry for ADRA2B (Alpha-2B adrenergic receptor)
|
Genomic Views
for ADRA2B gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000002.11 NC_018913.1 NT_022171.15
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the ADRA2B gene promoter:
GR Max1 GR-beta NF-YB CBF-A CBF-B CP1A GR-alpha c-Myc CBF(2)
Other transcription factors
Search SABiosciences Chromatin IP Primers for ADRA2B
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat ADRA2B |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 2q11.1 Ensembl cytogenetic band: 2q11.1 HGNC cytogenetic band: 2q11.1ADRA2B Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 2 GeneLoc Exon Structure GeneLoc location for GC02M096778: view genomic region
(about GC identifiers)
Start:
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96,778,623 bp from pter |
End:
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96,781,984 bp from pter |
Size:
|
3,362 bases |
Orientation:
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minus strand |
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Proteins
for ADRA2B gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: ADA2B_HUMAN, P18089 (See
protein sequence)Recommended Name: Alpha-2B adrenergic receptor Size: 450 amino acids; 49954 Da
Subunit: Interacts with RAB26
Subcellular location: Cell membrane; Multi-pass membrane protein. Note=Interaction with RAB26 mediates transport fromthe Golgi to the cell membrane
1 PDB 3D structure from  and Proteopedia  for ADRA2B:2CVA (3D)
Secondary accessions: Q4TUH9 Q53RF2 Q9BZK0Explore the universe of human proteins at neXtProt for ADRA2B: NX_P18089
Post-translational modifications:
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_P18089
ADRA2B Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins: NP_000673.2
ENSEMBL proteins: ENSP00000387281 Reactome Protein details: P18089
Human Recombinant Protein Products for ADRA2B:
Gene Ontology (GO): 2 cellular component terms (GO ID links to tree view): About this table
ADRA2B for ontologies About GeneDecksing
ADRA2B Antibody Products:
Assay Products for ADRA2B: |
Protein
Domains /
Families
for ADRA2B gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
ADRA2B for domains About GeneDecksing
4 InterPro domains/families:Graphical View of Domain Structure for InterPro Entry P18089ProtoNet protein and cluster: P18089 2 Blocks protein families: IPB000207 Alpha-2B adrenergic receptor signature IPB002233 Adrenergic receptor signature
UniProtKB/Swiss-Prot: ADA2B_HUMAN, P18089Similarity: Belongs to the G-protein coupled receptor 1 family. Adrenergic receptor subfamily. ADRA2B sub-subfamily |
Function
for ADRA2B gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
inGenious Targeting Laboratory,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase,
shRNA from
OriGene,
Sirion Biotech,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Sirion Biotech,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
Sirion Biotech,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Molecular Function:
UniProtKB/Swiss-Prot Summary: ADA2B_HUMAN, P18089Function: Alpha-2 adrenergic receptors mediate the catecholamine-induced inhibition of adenylate cyclase through theaction of G proteins. The rank order of potency for agonists of this receptor is clonidine > norepinephrine >epinephrine = oxymetazoline > dopamine > p-tyramine = phenylephrine > serotonin > p-synephrine / p-octopamine. Forantagonists, the rank order is yohimbine > chlorpromazine > phentolamine > mianserine > spiperone > prazosin >alprenolol > propanolol > pindolol Genatlas biochemistry entry for ADRA2B:adrenergic,alpha-2B-,receptor-like 1,G protein coupled receptor superfamily,inhibiting Ca2+ channels,contributing tothe patho genesis of obesity
Gene Ontology (GO): 4 molecular function terms (GO ID links to tree view): About this table
ADRA2B for ontologies About GeneDecksing
Phenotypes:
1 GenomeRNAi human phenotype for ADRA2B:
12 MGI mutant phenotypes (inferred from 1 allele ) (MGI details for Adra2b):
ADRA2B for phenotypes About GeneDecksing
Animal Models:
Mouse knock-out Adra2btm1Gsb for ADRA2B
Clone
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OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for ADRA2B
OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
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In Situ Assay
Products: |
 | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ADRA2B |
|
Pathways & Interactions
for ADRA2B gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Unified GeneCards pathways - 5/12 super-pathways (see all 12) About this table
See pathways by source
| Super-pathway | contained gene-specific pathways |
|---|
| 1 | Class A/1 (Rhodopsin-like receptors) | | | 2 | Activation of cAMP-Dependent PKA | | | 3 | Signaling by GPCR | | | 4 | Platelet activation, signaling and aggregation | | | 5 | Adrenoceptors | |
Pathway sources
See GeneCards unified pathways
Show all pathways
1 EMD Millipore Pathway for ADRA2B
5 Downloadable PowerPoint Slides of QIAGEN Pathway Central Maps for ADRA2B
1  GeneGo (Thomson Reuters) Pathway for ADRA2B
2  BioSystems Pathways for ADRA2B
5/13 
Reactome Pathways for ADRA2B (see all 13)
1  PharmGKB Pathway for ADRA2B
1 
Kegg Pathway (Kegg details for ADRA2B):
ADRA2B for pathways About GeneDecksing
Interactions:
Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for ADRA2B
STRING Interaction
Network Preview (showing 5 interactants - click image to see 25)
5/149 Interacting proteins for ADRA2B (P180893 ENSP000003872814) via UniProtKB, MINT, STRING, and/or I2D (see all 149)About this table
Gene Ontology (GO): 5/18 biological process terms (GO ID links to tree view) (see all 18): About this table
ADRA2B for ontologies About GeneDecksing
|
Drugs & Compounds
for ADRA2B gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
ADRA2B for compounds About GeneDecksing
Compounds for ADRA2B available from Tocris Bioscience About this table
6 HMDB Compounds for ADRA2B About this table
10/32 DrugBank Compounds for ADRA2B (see all 32) About this table
7 Novoseek chemical compound relationships for ADRA2B gene About this table
Search CenterWatch for drugs/clinical trials and news about ADRA2B / ADA2B
|
Transcripts
for ADRA2B gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
Sirion Biotech,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for ADRA2B gene: NM_000682.5 Unigene Cluster for ADRA2B: Adrenoceptor alpha 2B Hs.247686 [show with all ESTs]Unigene Representative Sequence: NM_0006821 Ensembl transcript including schematic representation, and UCSC links where relevant: ENST00000409345(uc021vlh.1)
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for ADRA2B (see all 3)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for ADRA2B
OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript: all cDNA clones in your preferred vector: ADRA2B (NM_000682) | | | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for ADRA2B | | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat ADRA2B |
Additional cDNA sequence: BC133021.1 BC136537.1 1 DOTS entry: DT.40128047 8 AceView cDNA sequences: AI791589 NM_000682 BF475329 BX111005 AI733093 AA887330 BQ880026 AW361747
GeneLoc Exon Structure
|
Expression
for ADRA2B gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| ADRA2B expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: --
About this image
See ADRA2B Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for ADRA2B
SOURCE GeneReport for Unigene cluster: Hs.247686
SABiosciences Expression via Pathway-Focused PCR Arrays including ADRA2B:
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for ADRA2B
Browse OriGene validated miRNA SYBR primer pairs
| | | SABiosciences RT2 qPCR Primer Assay in human, mouse, rat ADRA2B | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat ADRA2B | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat ADRA2B | In Situ
Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ADRA2B |
Orthologs
for ADRA2B gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
This gene was present in the common ancestor of animals.
Orthologs for ADRA2B gene from 5/17 species (see all 17) About this table
ENSEMBL Gene Tree for ADRA2B (if available)
TreeFam Gene Tree for ADRA2B (if available) |
Paralogs
for ADRA2B gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| Paralogs for ADRA2B gene
- DRD42 HTR1A2 ADRA1B2 DRD22 HTR1F2 HTR72 ADRA2C2 ADRA2A2
- HTR1D2 ADRA1A2 HTR1E2 DRD32 HTR5A2 HTR1B2 ADRA1D2
6 SIMAP similar genes for ADRA2B using alignment to 3 protein entries: ADA2B_HUMAN (see all proteins):ADRA2A ADRA2C HRH3 DRD2 5HT1A HTR1A
ADRA2B for paralogs About GeneDecksing
|
Genomic Variants
for ADRA2B gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
UniProtKB/Swiss-Prot: ADA2B_HUMAN, P18089Polymorphism: A rare polymorphic frameshift in position 451 produces a protein of 542 residues
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr 2 pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
|---|
HapMap Linkage Disequilibrium report for ADRA2B (96778623 - 96781984 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV) variations for ADRA2B: --
Human Gene Mutation Database (HGMD): ADRA2B
| SABiosciences Cancer Mutation PCR Assays |
| | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing ADRA2B |
|
Disorders
/ Diseases
for ADRA2B gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database, Novoseek,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
ADRA2B for disorders About GeneDecksing
OMIM gene information: 104260
OMIM disorders: --
20/26  diseases for ADRA2B (see all 26): About MalaCardsresting heart rate obesity attention deficit hyperactivity disorder orthostatic intolerance
type 2 diabetes mellitus polycystic ovary syndrome coronary restenosis essential hypertension
myocardial infarction atrial fibrillation diabetes, type 2 diabetes mellitus
morbid obesity peripheral neuropathy neuronitis cramps
neurologic diseases neuropathy hypertension migraine
5 Novoseek disease relationships for ADRA2B gene About this table
| Disease |
-log (P-Val) |
Hits |
PubMed IDs for Articles with Shared Sentences (# sentences) |
| resting heart rate |
45.4 |
2 |
16907703 (1) |
| essential hypertension |
26.7 |
1 |
10509541 (1) |
| glioma |
5.89 |
1 |
2169434 (1) |
| myocardial infarction |
0 |
1 |
12401126 (1) |
| breast cancer |
0 |
3 |
12878463 (1), 12270893 (1) |
Genetic Association Database (GAD): ADRA2B
Human Genome Epidemiology (HuGE) Navigator: ADRA2B (55 documents)
Export disorders for ADRA2B gene to outside databases
|
Publications
for ADRA2B gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for ADRA2B gene, integrated from 9 sources (see all 170):
(articles sorted by number of sources associating them with ADRA2B) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- Expansion of the alpha 2-adrenergic receptor family: cloning and characterization of a human alpha 2-adrenergic receptor subtype, the gene for which is located on chromosome 2. (PubMed id 2164221)1, 2, 3 Lomasney J.W.... Lefkowitz R.J. (1990)
- Variation in the alpha2B-adrenergic receptor gene (ADRA2B) and its relationship to vascular response in vivo. (PubMed id 15900214)1, 4, 9 Muszkat M....Stein C.M. (2005)
- Genetic variation at the human alpha2B-adrenergic receptor locus: role in blood pressure variation and yohimbine response. (PubMed id 15920038)1, 4, 9 Etzel J.P....Insel P.A. (2005)
- Deletion polymorphism in the alpha2B-adrenergic receptor gene is associated with flow-mediated dilatation of the brachial artery. (PubMed id 12401126)1, 4, 9 Heinonen P....Scheinin M. (2002)
- Alpha2B-adrenergic receptor deletion polymorphism and cardiac autonomic nervous system responses to exercise in obese women. (PubMed id 16247508)1, 4, 9 Ueno L.M....Negrao C.E. (2006)
- Human response to alpha2-adrenergic agonist stimulation studied in an isolated vascular bed in vivo: Biphasic influence of dose, age, gender, and receptor genotype. (PubMed id 15900285)1, 4, 9 King D....O'Connor D.T. (2005)
- Polymorphic deletion of three intracellular acidic residues of the alpha 2B-adrenergic receptor decreases G protein-coupled receptor kinase-mediated phosphorylation and desensitization. (PubMed id 11056163)1, 2, 9 Small K.M.... Liggett S.B. (2001)
- Alpha2B adrenergic receptor 301-303 deletion polymorphism and vascular alpha2 adrenergic receptor response. (PubMed id 15864122)1, 4, 9 Muszkat M....Stein C.M. (2005)
- Cloning, characterisation and identification of several polymorphisms in the promoter region of the human alpha2B-adrenergic receptor gene. (PubMed id 15037199)1, 2, 9 Cayla C.... Paris H. (2004)
- Cloning, expression, and pharmacological characterization of a human alpha 2B-adrenergic receptor. (PubMed id 2172775)1, 2, 9 Weinshank R.L.... Hartig P.R. (1990)
|
External Searches for ADRA2B gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
|
|
Genome Databases showing ADRA2B gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing ADRA2B gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing ADRA2B gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
| Name | Description |
| PharmGKB entry for ADRA2B | Pharmacogenomics, SNPs, Pathways | | SeattleSNPs | http://pga.gs.washington.edu/data/adra2b/ |
|
| | |
About This Section
| Patent Information for ADRA2B gene:
Search GeneIP for patents involving ADRA2B
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for ADRA2B gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0 and Sirion Biotech, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript, LifeMap BioReagents, and Sirion Biotech, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences, In Situ Hybridization Assays from
Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory)
About This Section
|
 | |
 | |
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| | |  | Browse OriGene Antibodies | | OriGene shRNA RFP for ADRA2B | | | OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for ADRA2B | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for ADRA2B | | | Browse OriGene Protein Over-expression Lysates | | Browse OriGene Fluorogenic Cell Assay Kits | | | OriGene siRNA for ADRA2B | | OriGene 3'-UTR Clone for ADRA2B | | | OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for ADRA2B | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for ADRA2B | | | Browse OriGene GFP tagged cDNA clones in CMV expression vector | | Browse OriGene MicroRNA Expression Plasmids | | | Browse OriGene basic RS shRNAs | | Browse OriGene validated miRNA SYBR primer pairs | | | Browse OriGene full length recombinant human proteins expressed in human HEK293 cells | | OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling | | | OriGene Custom Antibody Services for ADRA2B | | OriGene Custom Protein Services for ADRA2B | | | OriGene Custom Immunoassay Development | | |
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| | | QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat ADRA2B | | | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing ADRA2B | | | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat ADRA2B | | | QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat ADRA2B | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat ADRA2B | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat ADRA2B |
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 | | | | | | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ADRA2B |
|  |  |  |  | | | | ThermoFisher Antibodies for ADRA2B |
| | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat ADRA2B |
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