Free for academic non-profit institutions. Other users need a Commercial license

Aliases for ADRA2B Gene

Aliases for ADRA2B Gene

  • Adrenoceptor Alpha 2B 2 3 5
  • Alpha-2 Adrenergic Receptor Subtype C2 3 4
  • Alpha-2B Adrenoreceptor 3 4
  • Alpha-2BAR 3 4
  • ADRA2RL1 3 4
  • ADRA2L1 3 4
  • ADRA2B Adrenergic, Alpha-2B-, Receptor 3
  • Alpha-2-Adrenergic Receptor-Like 1 3
  • Adrenergic, Alpha-2B-, Receptor 2
  • Alpha-2B Adrenergic Receptor 3
  • G-Protein Coupled Receptor 3
  • Alpha-2B Adrenoceptor 4
  • ALPHA2BAR 3
  • ADRARL1 3
  • FAME2 3

External Ids for ADRA2B Gene

Previous HGNC Symbols for ADRA2B Gene

  • ADRA2L1
  • ADRA2RL1

Previous GeneCards Identifiers for ADRA2B Gene

  • GC02M094650
  • GC02M095232
  • GC02M096246
  • GC02M096263
  • GC02M096200
  • GC02M096142
  • GC02M096778
  • GC02M090739

Summaries for ADRA2B Gene

Entrez Gene Summary for ADRA2B Gene

  • This intronless gene encodes a seven-pass transmembrane protein. This protein is a member of a subfamily of G protein-coupled receptors that regulate neurotransmitter release from sympathetic nerves and from adrenergic neurons in the central nervous system. [provided by RefSeq, Apr 2014]

GeneCards Summary for ADRA2B Gene

ADRA2B (Adrenoceptor Alpha 2B) is a Protein Coding gene. Diseases associated with ADRA2B include Epilepsy, Myoclonic, Familial Adult, 2 and Benign Adult Familial Myoclonic Epilepsy. Among its related pathways are Signaling by GPCR and Peptide ligand-binding receptors. GO annotations related to this gene include G-protein coupled receptor activity and alpha2-adrenergic receptor activity. An important paralog of this gene is ADRA2C.

UniProtKB/Swiss-Prot for ADRA2B Gene

  • Alpha-2 adrenergic receptors mediate the catecholamine-induced inhibition of adenylate cyclase through the action of G proteins. The rank order of potency for agonists of this receptor is clonidine > norepinephrine > epinephrine = oxymetazoline > dopamine > p-tyramine = phenylephrine > serotonin > p-synephrine / p-octopamine. For antagonists, the rank order is yohimbine > chlorpromazine > phentolamine > mianserine > spiperone > prazosin > alprenolol > propanolol > pindolol.

Tocris Summary for ADRA2B Gene

  • Adrenergic alpha2 receptors (alpha2-adrenoceptors) are members of the adrenergic receptor group of G-protein-coupled receptors that also includes alpha1A, alpha1B, alpha1D, beta1, beta2 and beta3. Adrenergic alpha2 receptors are divided into three subtypes in humans: alpha2A, alpha2B and alpha2C.

Gene Wiki entry for ADRA2B Gene

No data available for PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ADRA2B Gene

Genomics for ADRA2B Gene

Regulatory Elements for ADRA2B Gene

Enhancers for ADRA2B Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH02F096155 1.1 FANTOM5 Ensembl ENCODE 21.5 -41.8 -41796 4.2 HDGF PKNOX1 ARID4B YBX1 YY1 ZNF143 ZNF207 KLF13 JUNB TBX21 ADRA2B GPAT2 GPAT2P1 ARID5A DUSP2 KANSL3 TMEM127 ASTL ENSG00000228873 GC02P096183
GH02F096071 0.2 ENCODE 20.7 +44.2 44156 1.7 ZNF121 POLR2A ZNF341 PRDM1 ADRA2B GPAT2 LOC105373494 GC02P096109
GH02F096240 0.8 Ensembl ENCODE 19.2 -125.7 -125727 3.3 CTCF PKNOX1 KLF1 ZIC2 ZBTB40 GLIS2 ZFHX2 EGR1 POLR2A NFYB ADRA2B GC02M096251 PIR52980
GH02F096091 0.4 Ensembl 12.7 +24.0 24045 1.2 CTCF KLF1 ZNF792 ZFP64 KLF17 ZIC2 RAD21 ZNF316 NFE2 MAFK FAHD2CP SNRNP200 ADRA2B ASTL DUSP2 GC02P096109 LOC105373494
GH02F095991 0.5 ENCODE 12.4 +123.8 123799 2.2 HDAC1 PKNOX1 ARID4B SIN3A DMAP1 ZNF48 ZNF2 RAD21 GLIS2 ZNF366 ADRA2B GPAT2 ANKRD36C RN7SL210P
- Elite enhancer/Elite enhancer-gene association Download Table
Download GeneHancer data dump

Enhancers around ADRA2B on UCSC Golden Path with GeneCards custom track

Promoters for ADRA2B Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00001825147 544 3000 CTCF MXI1 SIN3A RAD21 ZFHX2 GLIS2 POLR2A ZNF143 ZNF207 SMC3

Genomic Location for ADRA2B Gene

Chromosome:
2
Start:
96,112,875 bp from pter
End:
96,116,245 bp from pter
Size:
3,371 bases
Orientation:
Minus strand

Genomic View for ADRA2B Gene

Genes around ADRA2B on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ADRA2B Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ADRA2B Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ADRA2B Gene

Proteins for ADRA2B Gene

  • Protein details for ADRA2B Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P18089-ADA2B_HUMAN
    Recommended name:
    Alpha-2B adrenergic receptor
    Protein Accession:
    P18089
    Secondary Accessions:
    • Q4TUH9
    • Q53RF2
    • Q9BZK0

    Protein attributes for ADRA2B Gene

    Size:
    447 amino acids
    Molecular mass:
    49566 Da
    Quaternary structure:
    • Interacts with RAB26 (PubMed:23105096). Interacts with PPP1R9B (PubMed:24114805).

    Three dimensional structures from OCA and Proteopedia for ADRA2B Gene

neXtProt entry for ADRA2B Gene

Post-translational modifications for ADRA2B Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for ADRA2B Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for ADRA2B Gene

Domains & Families for ADRA2B Gene

Gene Families for ADRA2B Gene

Suggested Antigen Peptide Sequences for ADRA2B Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

P18089

UniProtKB/Swiss-Prot:

ADA2B_HUMAN :
  • Belongs to the G-protein coupled receptor 1 family. Adrenergic receptor subfamily. ADRA2B sub-subfamily.
Family:
  • Belongs to the G-protein coupled receptor 1 family. Adrenergic receptor subfamily. ADRA2B sub-subfamily.
genes like me logo Genes that share domains with ADRA2B: view

Function for ADRA2B Gene

Molecular function for ADRA2B Gene

GENATLAS Biochemistry:
adrenergic,alpha-2B-,receptor-like 1,G protein coupled receptor superfamily,inhibiting Ca2+ channels,contributing to the patho genesis of obesity
UniProtKB/Swiss-Prot Function:
Alpha-2 adrenergic receptors mediate the catecholamine-induced inhibition of adenylate cyclase through the action of G proteins. The rank order of potency for agonists of this receptor is clonidine > norepinephrine > epinephrine = oxymetazoline > dopamine > p-tyramine = phenylephrine > serotonin > p-synephrine / p-octopamine. For antagonists, the rank order is yohimbine > chlorpromazine > phentolamine > mianserine > spiperone > prazosin > alprenolol > propanolol > pindolol.

Gene Ontology (GO) - Molecular Function for ADRA2B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004871 signal transducer activity IEA --
GO:0004930 G-protein coupled receptor activity IEA --
GO:0004935 adrenergic receptor activity IEA --
GO:0004938 alpha2-adrenergic receptor activity IEA,IDA 17215105
GO:0005515 protein binding IPI 16531006
genes like me logo Genes that share ontologies with ADRA2B: view
genes like me logo Genes that share phenotypes with ADRA2B: view

Human Phenotype Ontology for ADRA2B Gene

HPO Id HPO Name Alternative Ids Definition Synonyms

Animal Models for ADRA2B Gene

MGI Knock Outs for ADRA2B:

Animal Model Products

Inhibitory RNA Products

Clone Products

  • R&D Systems cDNA Clones for ADRA2B (alpha-2B Adrenergic R/ADRA2B)

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Transcription Factor Targets and HOMER Transcription for ADRA2B Gene

Localization for ADRA2B Gene

Subcellular locations from UniProtKB/Swiss-Prot for ADRA2B Gene

Cell membrane; Multi-pass membrane protein. Note=Interaction with RAB26 mediates transport from the Golgi to the cell membrane.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for ADRA2B Gene COMPARTMENTS Subcellular localization image for ADRA2B gene
Compartment Confidence
plasma membrane 5
endoplasmic reticulum 1
nucleus 1

Gene Ontology (GO) - Cellular Components for ADRA2B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005886 plasma membrane IEA,TAS --
GO:0005887 integral component of plasma membrane TAS 2164221
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with ADRA2B: view

Pathways & Interactions for ADRA2B Gene

genes like me logo Genes that share pathways with ADRA2B: view

Interacting Proteins for ADRA2B Gene

Gene Ontology (GO) - Biological Process for ADRA2B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003056 regulation of vascular smooth muscle contraction IEA --
GO:0006940 regulation of smooth muscle contraction IEA --
GO:0007165 signal transduction IEA --
GO:0007186 G-protein coupled receptor signaling pathway IEA,TAS 2164221
GO:0007267 cell-cell signaling TAS 2164221
genes like me logo Genes that share ontologies with ADRA2B: view

No data available for SIGNOR curated interactions for ADRA2B Gene

Drugs & Compounds for ADRA2B Gene

(147) Drugs for ADRA2B Gene - From: DrugBank, ApexBio, DGIdb, IUPHAR, HMDB, Tocris, and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Yohimbine Approved, Vet_approved Pharma Antagonist, antagonist, Target 27
Apomorphine Approved, Investigational Pharma Partial agonist, Agonist, agonist, Target 37
Brimonidine Approved Pharma Full agonist, Agonist, agonist, Target 0
Bromocriptine Approved, Investigational Pharma Antagonist, agonist, Target 31
Cabergoline Approved Pharma Antagonist, agonist, Target, antagonist 46

(4) Additional Compounds for ADRA2B Gene - From: HMDB, IUPHAR, Novoseek, and Tocris

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
(plusmn)-adrenaline
Partial agonist, Agonist
p-Octopamine
  • (RS)-Octopamine
  • 1-(p-Hydroxyphenyl)-2-aminoethanol
  • 2-Amino-1-(4-hydroxyphenyl)ethanol
  • 4-Hydroxyphenethanolamine
  • 4-[2-Amino-1-hydroxyethyl]phenol
104-14-3
Medetomidine hydrochloride
86347-15-1

(5) Tocris Compounds for ADRA2B Gene

Compound Action Cas Number
Atipamezole hydrochloride Selective alpha2 antagonist 104075-48-1
BRL 44408 maleate Selective alpha2A antagonist 681806-46-2
Imiloxan hydrochloride Highly selective alpha2B antagonist 81167-22-8
Medetomidine hydrochloride Potent, highly selective alpha2 agonist 86347-15-1
RS 79948 hydrochloride Potent, selective alpha2 antagonist 186002-54-0

(61) ApexBio Compounds for ADRA2B Gene

Compound Action Cas Number
Acebutolol HCl 34381-68-5
Adrenalone HCl 62-13-5
Alfuzosin HCl α1 adrenoceptor antagonist,functionally uro-selective 81403-68-1
ARC 239 dihydrochloride α2B adrenoceptor antagonist 55974-42-0
Bambuterol 81732-65-2
Betaxolol βadrenergic receptor blocker 659-18-7
Betaxolol HCl 63659-19-8
Bisoprolol fumarate 104344-23-2
Brimonidine Tartrate 70359-46-5
Carvedilol 72956-09-3
Cisatracurium Besylate Neuromuscular-blocking drug 96946-42-8
Clonidine HCl 4205-91-8
Detomidine HCl 90038-01-0
Dexmedetomidine 113775-47-6
Dexmedetomidine HCl 145108-58-3
DL-Adrenaline 329-65-7
Doxazosin Mesylate α1-adrenergic receptor antagonist 77883-43-3
Droxidopa 23651-95-8
Epinephrine Bitartrate 51-42-3
Epinephrine HCl 55-31-2
Formoterol Hemifumarate 43229-80-7
Guanabenz Acetate 23256-50-0
Indacaterol Maleate 753498-25-8
Isoprenaline HCl 51-30-9
Ivabradine HCl 148849-67-6
Labetalol HCl 32780-64-6
L-Adrenaline 51-43-4
Maprotiline HCl 10347-81-6
Medetomidine HCl 86347-15-1
Methyldopa 555-30-6
Metoprolol Tartrate β1-adrenergic blocking agent 392-17-7
Mirabegron (YM178) 223673-61-8
Moxonidine I1R/α2AR agonist 75438-57-2
Naftopidil α1-adrenergic receptor antagonist 57149-07-2
Naftopidil DiHCl 57149-08-3
Naphazoline HCl 550-99-2
Nebivolol 152520-56-4
Nedaplatin 95734-82-0
Noradrenaline bitartrate monohydrate 108341-18-0
Oxymetazoline HCl Alpha-1/alpha-2 agonist 2315-02-8
Phenoxybenzamine HCl 63-92-3
Phentolamine Mesylate Alpha 1/2-blocking agent 65-28-1
Phenylephrine HCl 61-76-7
Prazosin HCl α1 and α2B-adrenoceptor antagonist 19237-84-4
Propranolol HCl 318-98-9
Ritodrine HCl β-2 adrenergic receptor agonist 23239-51-2
Salbutamol Sulfate β-2 adrenergic receptor agonist 51022-70-9
Salmeterol xinafoate β2-adrenergic receptor agonist 94749-08-3
Scopine 498-45-3
Setiptiline Serotonin receptor antagonist 57262-94-9
Silodosin α1-adrenoceptor antagonist 160970-54-7
Synephrine HCl 5985-28-4
Terazosin HCl 70024-40-7
Terbutaline Sulfate 23031-32-5
Tetrahydrozoline HCl 522-48-5
Timolol Maleate 26921-17-5
Tizanidine HCl 64461-82-1
Tolazoline HCl 59-97-2
Xylazine α2-adrenoceptor agonist 7361-61-7
Xylazine HCl α2 Adrenoceptor agonist 23076-35-9
Xylometazoline HCl 1218-35-5
genes like me logo Genes that share compounds with ADRA2B: view

Transcripts for ADRA2B Gene

mRNA/cDNA for ADRA2B Gene

(1) REFSEQ mRNAs :
(2) Additional mRNA sequences :
(8) Selected AceView cDNA sequences:
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for ADRA2B Gene

Adrenoceptor alpha 2B:
Representative Sequences:

Inhibitory RNA Products

Clone Products

  • R&D Systems cDNA Clones for ADRA2B (alpha-2B Adrenergic R/ADRA2B)

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for ADRA2B Gene

No ASD Table

Relevant External Links for ADRA2B Gene

GeneLoc Exon Structure for
ADRA2B
ECgene alternative splicing isoforms for
ADRA2B

Expression for ADRA2B Gene

mRNA expression in normal human tissues for ADRA2B Gene

Protein differential expression in normal tissues from HIPED for ADRA2B Gene

This gene is overexpressed in Heart (69.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for ADRA2B Gene



Protein tissue co-expression partners for ADRA2B Gene

NURSA nuclear receptor signaling pathways regulating expression of ADRA2B Gene:

ADRA2B

SOURCE GeneReport for Unigene cluster for ADRA2B Gene:

Hs.247686
genes like me logo Genes that share expression patterns with ADRA2B: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for ADRA2B Gene

Orthologs for ADRA2B Gene

This gene was present in the common ancestor of animals.

Orthologs for ADRA2B Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia ADRA2B 34
  • 98.48 (n)
dog
(Canis familiaris)
Mammalia ADRA2B 34
  • 89.11 (n)
cow
(Bos Taurus)
Mammalia ADRA2B 34
  • 87.72 (n)
rat
(Rattus norvegicus)
Mammalia Adra2b 34
  • 84.79 (n)
mouse
(Mus musculus)
Mammalia Adra2b 34 16
  • 83.97 (n)
chicken
(Gallus gallus)
Aves LOC101751513 34
  • 75.45 (n)
tropical clawed frog
(Silurana tropicalis)
Amphibia adra2b 34
  • 60.48 (n)
zebrafish
(Danio rerio)
Actinopterygii adra2b 34
  • 58.22 (n)
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP000606 34
  • 57.28 (n)
fruit fly
(Drosophila melanogaster)
Insecta CG7431 36
  • 46 (a)
CG18208 36
  • 44 (a)
worm
(Caenorhabditis elegans)
Secernentea dop-1 34
  • 47.49 (n)
Species where no ortholog for ADRA2B was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for ADRA2B Gene

ENSEMBL:
Gene Tree for ADRA2B (if available)
TreeFam:
Gene Tree for ADRA2B (if available)

Paralogs for ADRA2B Gene

(6) SIMAP similar genes for ADRA2B Gene using alignment to 3 proteins:

genes like me logo Genes that share paralogs with ADRA2B: view

Variants for ADRA2B Gene

Polymorphic Variants from UniProtKB/Swiss-Prot for ADRA2B Gene

ADA2B_HUMAN-P18089
A rare polymorphic frameshift in position 448 produces a protein of 542 residues.
ADA2B_HUMAN-P18089
The gene is polymorphic at position 300. The sequence shown here is found with a frequency of 0.31 in Caucasians and 0.12 in African-Americans. It exhibits impaired phosphorylation and desensitization by GRKs compared to the sequence including a stretch of glutamic acid at that position.

Sequence variations from dbSNP and Humsavar for ADRA2B Gene

SNP ID Clin Chr 02 pos Sequence Context AA Info Type
rs879255577 Pathogenic 96,115,464(-) GACCA(GTTTGGCAG/TGGTGGGGCTTT)GGCCT cds-indel
rs786205528 Likely pathogenic 96,115,486(-) AGCCC(C/T)GACCC reference, stop-gained
rs10180765 -- 96,117,936(+) GCTCC(C/T)TCCAT upstream-variant-2KB
rs11464083 -- 96,112,917(+) AGTTT(-/A)TAAAA utr-variant-3-prime
rs115330804 -- 96,117,249(+) TTAGG(A/C)CTTCG upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for ADRA2B Gene

Variant ID Type Subtype PubMed ID
dgv4009n100 CNV gain 25217958
dgv607e201 CNV deletion 23290073
esv3425717 CNV duplication 20981092
esv3591652 OTHER inversion 21293372
esv5003 OTHER complex 18987735
nsv1135873 CNV deletion 24896259
nsv2834 CNV deletion 18451855

Variation tolerance for ADRA2B Gene

Residual Variation Intolerance Score: 69.4% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.62; 31.12% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for ADRA2B Gene

Human Gene Mutation Database (HGMD)
ADRA2B
SNPedia medical, phenotypic, and genealogical associations of SNPs for
ADRA2B

Disorders for ADRA2B Gene

MalaCards: The human disease database

(5) MalaCards diseases for ADRA2B Gene - From: OMIM, ClinVar, Orphanet, DISEASES, Novoseek, and GeneCards

Disorder Aliases PubMed IDs
epilepsy, myoclonic, familial adult, 2
  • epilepsy, familial adult myoclonic, 2
benign adult familial myoclonic epilepsy
  • adcme
orthostatic intolerance
  • neurocirculatory asthenia
obesity
  • obesity, association with
hypertension, essential
  • hypertension, essential 3
- elite association - COSMIC cancer census association via MalaCards

UniProtKB/Swiss-Prot

ADA2B_HUMAN
  • Epilepsy, familial adult myoclonic, 2 (FAME2) [MIM:607876]: A form of cortical myoclonic tremor with epilepsy, a syndrome characterized by cortical myoclonus and variable occurrence of epileptic seizures. Usually, myoclonic tremor is the presenting symptom, characterized by tremulous finger movements and myoclonic jerks of the limbs increased by action and posture. In a minority of patients, seizures are the presenting symptom; both complex partial as well as generalized tonic clonic seizures are described. Some patients exhibit mild cognitive impairment. {ECO:0000269 PubMed:24114805}. Note=The disease is caused by mutations affecting the gene represented in this entry.

Relevant External Links for ADRA2B

Genetic Association Database (GAD)
ADRA2B
Human Genome Epidemiology (HuGE) Navigator
ADRA2B
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
ADRA2B
genes like me logo Genes that share disorders with ADRA2B: view

No data available for Genatlas for ADRA2B Gene

Publications for ADRA2B Gene

  1. Desensitization of vascular response in vivo: contribution of genetic variation in the [alpha]2B-adrenergic receptor subtype. (PMID: 20051907) Muszkat M. … Stein C.M. (J. Hypertens. 2010) 3 22 46 64
  2. Chromosome 2q12, the ADRA2B I/D polymorphism and metabolic syndrome. (PMID: 19593211) Fava C. … Melander O. (J. Hypertens. 2009) 3 22 46 64
  3. A genetic variation of the noradrenergic system is related to differential amygdala activation during encoding of emotional memories. (PMID: 19826083) Rasch B. … de Quervain D.J. (Proc. Natl. Acad. Sci. U.S.A. 2009) 3 22 46 64
  4. Physical activity, diet, and incident diabetes in relation to an ADRA2B polymorphism. (PMID: 17277585) Laaksonen D.E. … Uusitupa M. (Med Sci Sports Exerc 2007) 3 22 46 64
  5. Job strain, decision latitude and alpha2B-adrenergic receptor polymorphism significantly interact, and associate with higher blood pressures in men. (PMID: 17620957) Ohlin B. … Melander O. (J. Hypertens. 2007) 3 22 46 64

Products for ADRA2B Gene

Sources for ADRA2B Gene

Content
Loading form....