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ADRA2B Gene

protein-coding GIFtS: 59

GC02M096200

adrenergic, alpha-2B-, receptor
Symbol approved by the HUGO Gene Nomenclature Committee (HGNC) database
(Previous symbols: ADRA2L1, ADRA2RL1)

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc , and/or ⁷Ensembl, ⁸miRBase)
About This Section

Aliases
ADRA2L1 ^², ³, ⁵
ADRA2RL1 ^², ³
ADRARL1 ^¹, ²
ALPHA2BAR ^²

Descriptions
ADRA2B adrenergic, alpha-2B-, receptor ^²
Alpha-2 adrenergic receptor subtype C2 ^³
Alpha-2B adrenoceptor ^³
Alpha-2B adrenoreceptor ^³
G-protein coupled receptor ^²
adrenergic receptor alpha 2B ^²
adrenergic, alpha-2B-, receptor ^²
alpha-2-adrenergic receptor-like 1 ^²
alpha-2B-adrenergic receptor ^²

External Ids
HGNC: 282¹
Entrez Gene: 151²
UniProtKB: P18089³
Ensembl: ENSG00000222040⁷

Search outside databases for aliases for ADRA2B gene

Previous GC identifers: GC02M094650 GC02M095232 GC02M096246 GC02M096263

(According to Entrez Gene, Wikipedia's Gene Wiki,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

EntrezGene summary for ADRA2B:

Alpha-2-adrenergic receptors are members of the G protein-coupled receptor superfamily. They

include 3 highly homologous subtypes: alpha2A, alpha2B, and alpha2C. These receptors have a

critical role in regulating neurotransmitter release from sympathetic nerves and from adrenergic

neurons in the central nervous system. This gene encodes the alpha2B subtype, which was observed

to associate with eIF-2B, a guanine nucleotide exchange protein that functions in regulation of

translation. A polymorphic variant of the alpha2B subtype, which lacks 3 glutamic acids from a

glutamic acid repeat element, was identified to have decreased G protein-coupled receptor

kinase-mediated phosphorylation and desensitization; this polymorphic form is also associated with

reduced basal metabolic rate in obese subjects and may therefore contribute to the pathogenesis of

obesity. This gene contains no introns in either its coding or untranslated sequences. [provided

by RefSeq]

UniProtKB/Swiss-Prot: ADA2B_HUMAN, P18089

Function: Alpha-2 adrenergic receptors mediate the catecholamine-induced inhibition of adenylate

cyclase through the action of G proteins. The rank order of potency for agonists of this receptor

is clonidine > norepinephrine > epinephrine = oxymetazoline > dopamine > p-tyramine =

phenylephrine > serotonin > p-synephrine / p-octopamine. For antagonists, the rank order is

yohimbine > chlorpromazine > phentolamine > mianserine > spiperone > prazosin > alprenolol >

propanolol > pindolol

Gene Wiki entry for ADRA2B (Alpha-2B_adrenergic_receptor)

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 36),
and/or miRBase,
Genomic Views according to UCSC and Ensembl, Transcription factor binding sites according to SABiosciences)
About This Section

Genomic View:

UCSC Golden Path with GeneCards custom track

Transcription factor binding sites upstream to the ADRA2B gene

Entrez Gene cytogenetic band: 2p13-q13 Ensembl cytogenetic band: 2q11.2 HGNC chromosome: 2

ADRA2B Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)

GeneLoc gene densities for chromosome 2 GeneLoc Exon Structure

GeneLoc location for GC02M096200: (about GC identifiers)

Start:	96,142,350 bp from pter
End:	96,145,711 bp from pter
Size:	3,362 bases
Orientation:	minus strand

RefSeq DNA sequence:

NC_000002.10 NT_026970.9

(According to ¹UniProtKB, and/or Ensembl, Phosphorylation sites according to ²Phosphosite, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Enzo Life Sciences, Abnova, OriGene and/or, Abcam,
Biochemical Assays by Invitrogen, Millipore, R&D Systems, Cell Signaling Technology, and/or Enzo Life Sciences, Ontologies according to Gene Ontology Consortium 01 Apr 2009 and Entrez Gene, Antibodies by Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Cell Signaling Technology, Abcam, Abnova, and/or Novus Biologicals)
About This Section

UniProtKB/Swiss-Prot: ADA2B_HUMAN, P18089 (See protein sequence)

Recommended Name: Alpha-2B adrenergic receptor

Size: 450 amino acids; 49954 Da

Subcellular location: Cell membrane; Multi-pass membrane protein

PDB structures from and Proteopedia :

2CVA (3D)

Secondary accessions: Q4TUH9 Q53RF2 Q9BZK0

REFSEQ proteins: NP_000673.2

ENSEMBL proteins:

ENSP00000387281

Human Recombinant Proteins

	Browse Drug Discovery Central at Invitrogen for human recombinant proteins
	Millipore Purified and/or Recombinant ADRA2B Protein
	Browse Human Recombinant Proteins at Sigma-Aldrich
	Browse R&D Systems for human recombinant proteins
	Browse recombinant and purified proteins available from Enzo Life Sciences
	Recombinant Proteins from Abcam (alpha 2b Adrenergic Receptor)
	Browse Abnova for Human Recombinant Proteins

Browse Origene for full length recombinant human proteins expressed in human HEK293 cells

2 Gene Ontology (GO) cellular component terms (links to tree view):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005886	plasma membrane	TAS	2164221
GO:0005887	integral to plasma membrane	TAS	2164221

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Antibodies for ADRA2B:

	Browse Antibodies Central at Invitrogen
	Browse Millipore's Extensive Line of Mono- and Polyclonal Antibodies
	Sigma-Aldrich Antibodies for ADRA2B
	Browse R&D Systems for Antibodies
	Antibodies from Abcam (alpha 2b Adrenergic Receptor), each with their Abpromise^SM
	Browse Abnova for Monoclonal and Polyclonal Antibodies
	Search Novus for antibodies for ADRA2B

Assays for ADRA2B:

	Browse Invitrogen for biochemical assays
	Browse Kits and Assays available from Millipore
	Browse R&D Systems for biochemical assays
	Browse biochemical assays available from Enzo Life Sciences

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

Graphical View of Domain Structure for InterPro Entry P18089

ProtoNet protein and cluster: P18089

2 Blocks protein families:

IPB000207 Alpha-2B adrenergic receptor signature

IPB002233 Adrenergic receptor signature

UniProtKB/Swiss-Prot: ADA2B_HUMAN, P18089

Similarity: Belongs to the G-protein coupled receptor 1 family

(According to MGI Jun 06 2009, UniProtKB, IUBMB,and/or Genatlas,
shRNA from OriGene, Sigma-Aldrich, RNAi from Sigma-Aldrich,
RNAi Products, Clones, and Q-PCR Products from Invitrogen, Millipore, OriGene, and/or Abnova, siRNAs from Applied Biosystems, SYBR primers from OriGene, Cell-based Assays from Millipore, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
About This Section

Inhib. RNA:		Invitrogen RNAi Products for gene knock-down (ADRA2B)
		Browse for Gene Knock-down Tools from Millipore
		Abnova Chimera RNAi Products for Gene knock-down (ADRA2B)

OriGene 29mer shRNA kit in GFP-retroviral vector: NM_000682

Applied Biosystems Silencer® siRNAs for ADRA2B

Sigma-Aldrich siRNA and siRNA Panels for ADRA2B

Sigma-Aldrich shRNA Panels and shRNA for ADRA2B

Explore Sigma-Aldrich super-pooled esiRNAs

Clones:		Browse Clone Ranger at Invitrogen for clones
		Millipore Clones for the Expression of ADRA2B

OriGene GFP tagged cDNA clone in CMV expression vector: NM_000682
Myc/DDK tagged cDNA clone in CMV expression vector: NM_000682
untagged cDNA clone in CMV expression vector: NM_000682

Primers:

Browse Quantitative PCR Central at Invitrogen for Q-PCR LUX™ Primers

OriGene genome-wide validated SYBR primer pairs: NM_000682

UniProtKB/Swiss-Prot: ADA2B_HUMAN, P18089

Function: Alpha-2 adrenergic receptors mediate the catecholamine-induced inhibition of adenylate

cyclase through the action of G proteins. The rank order of potency for agonists of this receptor

is clonidine > norepinephrine > epinephrine = oxymetazoline > dopamine > p-tyramine =

phenylephrine > serotonin > p-synephrine / p-octopamine. For antagonists, the rank order is

yohimbine > chlorpromazine > phentolamine > mianserine > spiperone > prazosin > alprenolol >

propanolol > pindolol

Genatlas biochemistry entry for ADRA2B:

adrenergic,alpha-2B-,receptor-like 1,G protein coupled receptor superfamily,inhibiting Ca2+

channels,contributing to the patho genesis of obesity

8 MGI mutant phenotypes (inferred from 1 allele) (MGI details for Adra2b):

	behavior/neurological	embryogenesis	homeostasis/metabolism	lethality-postnatal
lethality-prenatal/perinatal	renal/urinary system	reproductive system

5 Gene Ontology (GO) molecular function terms (links to tree view):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0004872	receptor activity	IEA	--
GO:0004930	G-protein coupled receptor activity	IEA	--
GO:0004935	adrenoceptor activity	IEA	--
GO:0004938	alpha2-adrenergic receptor activity	TAS	2164221
GO:0005515	protein binding	IEA	--

About this table

(Pathways according to Invitrogen (maps by GeneGo), Millipore, Cell Signaling Technology, Sigma-Aldrich, KEGG and/or UniProtKB,
Sets of similar genes according to GeneDecks, Proteins Network according to SABiosciences, Interactions according to ¹UniProtKB, ²MINT, and/or ³STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
About This Section

3 Sigma-Aldrich "Your Favorite Gene" Pathways for ADRA2B (Your Favorite Gene powered by Ingenuity)

G-Protein Coupled Receptor Signaling
Cardiac Hypertrophy Signaling
cAMP-mediated Signaling

GeneDecks ADRA2B for the pathways selected above

About GeneDecksing

5 Gene Ontology (GO) biological process terms (links to tree view):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0000165	MAPKKK cascade	IEA	--
GO:0001525	angiogenesis	IEA	--
GO:0007165	signal transduction	IEA	--
GO:0007186	G-protein coupled receptor protein signaling pathway	TAS	2164221
GO:0007267	cell-cell signaling	TAS	2164221

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(Chemical Compounds according to UniProtKB, Enzo Life Sciences, Sigma-Aldrich, Tocris Bioscience, and/or Novoseek and Drugs according to Enzo Life Sciences and/or PharmGKB)
About This Section

Enzo Life Sciences drugs & compounds for ADRA2B

Sigma-Aldrich Small Molecules for ADRA2B:

Mixed Agonist/Antagonist Antagonist Blocker Agonist

Compounds for ADRA2B available from Tocris Bioscience

Compound	Action	CAS number
Imiloxan hydrochloride	Highly selective alpha2B antagonist	[81167-16-0]
Guanfacine hydrochloride	alpha2A agonist	[29110-48-3]
Medetomidine hydrochloride	Potent, highly selective alpha2 agonist	[106807-72-1]

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4 Novoseek chemical compound relationships for ADRA2B gene

Compound	Score	Articles	PubMed IDs for Articles with Shared Sentences (# sentences)
nadh	19.71	3	11158372 (1), 12878463 (1)
sucrose	6.61	1	8170959 (1)
cholesterol	0.00	1	12401126 (1)
glucose	0.00	1	15309292 (1)

About this table

(GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 219 Homo sapiens; Jun 2 2009) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView,
non coding RNAs according to RNAdb,
ESTs according to GeneTide,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from Invitrogen, Millipore, and/or Abnova,
siRNAs from Applied Biosystems, Sigma-Aldrich,
shRNA from Sigma-Aldrich, OriGene,
Tagged/untagged cDNA clones from OriGene,
Expression Assays from Applied Biosystems)
About This Section

Inhib. RNA:		Invitrogen RNAi Products for gene knock-down (ADRA2B)
		Browse for Gene Knock-down Tools from Millipore
		Abnova Chimera RNAi Products for Gene knock-down (ADRA2B)

OriGene 29mer shRNA kit in GFP-retroviral vector: NM_000682

Sigma-Aldrich siRNA and siRNA Panels for ADRA2B

Sigma-Aldrich shRNA Panels and shRNA for ADRA2B

Explore Sigma-Aldrich super-pooled esiRNAs

Applied Biosystems Silencer® siRNAs:

NM_000682

REFSEQ mRNAs for ADRA2B gene:

NM_000682.5

Applied Biosystems TaqMan ® Gene Expression Assays:

NM_000682

              OriGene GFP tagged cDNA clone in CMV expression vector: NM_000682
                                 Myc/DDK tagged cDNA clone in CMV expression vector: NM_000682
                                 untagged cDNA clone in CMV expression vector: NM_000682

Additional cDNA sequence:

BC133021.1 BC136537.1

1 DOTS entry:

DT.40128047

8 AceView cDNA sequences:

AI791589 NM_000682 BX111005 BF475329 AA887330 AI733093 BQ880026 AW361747

highest scoring ESTs for ADRA2B:

AI791589 AA887330 AI733093 BQ880026 BX111005 NM_000682 BF475329 CO960636 CO960652 CV806541

Unigene Cluster for ADRA2B:

Adrenergic, alpha-2B-, receptor

Hs.247686 [show with all ESTs]

Unigene Representative Sequence: NM_000682

GeneLoc Exon Structure

1 Ensembl transcript including schematic representation:

ENST00000409345

(Experimental results according to ¹GeneNote and GNF BioGPS,
probe sets-to-genes annotations according to ²GeneAnnot , ³GeneTide , Sets of similar genes according to GeneDecks, Electronic Northern calculations according to data from UniGene (Build 219 Homo sapiens), SAGE tags according to CGAP, plus additional links to SOURCE, and/or GNF BioGPS, and/or EXPOLDB, and/or UniProtKB,
Expression Assays from Applied Biosystems )
About This Section

ADRA2B expression in normal and diseased human tissues

Applied Biosystems TaqMan ® Gene Expression Assays for ADRA2B

¹ / ² / ³

3 probe-sets matching ADRA2B gene

Affymetrix probe-set	Array	# genes	Sensitivity	Specificity	Correlation	Length	Gb_Accession	Consensus	Uniqueness	Score	Rank
Affymetrix probe-set	Array	GeneAnnot data			GeneNote data		GeneTide data
90674_at²^{, 3}	U95-D	2	1.00	0.97	1.00	1.00	AI791589	0.80	1.00	0.91	1
208544_at²^{, 3}	U133-A	1	0.91	1.00	--	--	NM_000682	0.60	1.00	0.82	1
208544_at²	U133Plus2	1	0.91	1.00	--	--	--	--	--	--	--

About this table

Data from

(Publications) and GNF BioGPS
About these images
About these images

CGAP SAGE TAG: --

SOURCE GeneReport for Unigene cluster: Hs.247686

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD and/or ⁵MGI Jun 06 2009, with possible further links to Flybase and/or WormBase, Gene Trees according to Ensembl)
About This Section

Orthologs for ADRA2B gene from 5/8 species (see all 8 )

Organism	Gene	Locus	Description	Human Similarity	NCBI accessions
dog (Canis familiaris)	ADRA2B¹	--	adrenergic, alpha-2B-, receptor	89.19(n) 90.99(a)	611658 XM_849354.1 XP_854447.1
chimpanzee (Pan troglodytes)	ADRA2B¹	--	adrenergic, alpha-2B-, receptor	98.84(n) 97.86(a)	459410 XM_515627.2 XP_515627.2
cow (Bos taurus)	ADRA2B¹	--	adrenergic, alpha-2B-, receptor	87.72(n) 88.76(a)	516422 XM_594575.2 XP_594575.2
rat (Rattus norvegicus)	Adra2b¹	--	adrenergic, alpha-2B-, receptor	84.71(n) 84.56(a)	24174 NM_138505.1 NP_612514.1
mouse (Mus musculus)	Adra2b^{1, 5}	2 (71.00 cM)⁵	adrenergic receptor, alpha 2b^{1, 5}	84.34(n)¹ 83.89(a)¹	11552¹ NM_009633.3¹ NP_033763.2¹ AF332049⁵ AF332050⁵ (see all 11)

About this table Species with no ortholog for ADRA2B

ENSEMBL Gene Tree for ADRA2B

(Paralogs according to ¹HomoloGene
and ²Ensembl, Pseudogenes according to ³Pseudogene.org)
About This Section

Paralogs for ADRA2B gene

ADRA2A² HTR5A² ADRA2C² HTR7²

(According to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, and UniProtKB, Linkage Disequilibrium by HapMap, Genotyping Reagents from Applied Biosystems)
About This Section

UniProtKB/Swiss-Prot: ADA2B_HUMAN, P18089

Polymorphism: A rare polymorphic framshift in position 451 produces a protein of 542 residues

10/71 NCBI SNPs in ADRA2B are shown (see all 71 )
(Click for Applied Biosystems TaqMan ® Genotyping Assay) (see all 49)

AB	SNP ID	Valid	Chr 2 pos	Sequence	Recs	AA Chg	Type	More	Recs	Allele freq	Pop	Total sample	More
AB	Genomic Data				Transcription Data				Allele Frequencies
				--	--	--		--	--				--
	rs4426564^1,2	A,C,F,H	96144713(+)	`TCCTCT/CTCCTC`	2	E/EEEE	fra¹		4		EU EA WA	416
	rs3813662^1,2	C,F,H	96143422(-)	`CACACT/GAGAGA`	1	--	ut3¹		12		EA EU WA MN NA	2335
--	rs4907299^1,2	A,C,F	96143849(+)	`TTTGTG/TGGTGG`	1	--	ut3¹		7		NS MN NA	969
--	rs28365031^1,2	C,F	96144715(-)	`AGGAGGAAGA GGAG/-GAGGA`	1	EKRR/E	fra¹		2		--	696
	rs35994755^1,2	C,F	96143636(-)	`TGGATC/GGGCTT`	1	--	ut3¹		2		MN	141
	rs2252697^1,2	A,C	96141917(+)	`ACCCGC/GGGCTA`	1	--	ng5¹		0	--	--	--	--
	rs29000571^1,2	C,F	96143809(-)	`AGTGGG/AGCCTG`	1	--	ut3¹		4		NS MN	233
	rs29000576^1,2	C,F	96142770(-)	`GTGGAA/GAGGAG`	1	--	ut3¹		3		NS NA	136
--	rs9333568^1,2	C,F	96144984(-)	`CAAGGG/CGGGGC`	1	A/G	mis¹		5		EU NS MN	561
--	rs29000569^1,2	C,F	96144490(-)	`TTGGCG/ATTTTT`	1	I/V	mis¹		4		NS MN	233

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HapMap Linkage Disequilibrium images for ADRA2B (up to first 250kb)

(in which this Gene is Involved, According to OMIM, UniProtKB, Novoseek, PharmGKB, Genatlas, GeneTests, Blood group antigen gene mutations by BGMUT, HGMD, GAD, HuGE Navigator, BCGD, and/or TGDB.)
About This Section

OMIM: 104260

5 Novoseek disease relationships for ADRA2B gene

Disease	Score	Articles	PubMed IDs for Articles with Shared Sentences (# sentences)
resting heart rate	47.90	2	16907703 (1)
essential hypertension	29.03	1	10509541 (1)
glioma	9.19	1	2169434 (1)
myocardial infarction	0.00	1	12401126 (1)
breast cancer	0.00	3	12878463 (1), 12270893 (1)

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Human Gene Mutation Database: ADRA2B
Genetic Association Database: ADRA2B
Human Genome Epidemiology Navigator: ADRA2B (36 documents)

(Possibly Related Articles in Doctor's Guide)
About This Section

(in PubMed. Associations of this gene to articles via ¹Novoseek, ²HGNC, ³Entrez Gene, ⁴UniProtKB/Swiss-Prot, ⁵UniProtKB/TrEMBL, ⁶GAD, and/or ⁷PharmGKB)
About This Section

10/91 PubMed articles for ADRA2B gene (see all 91 ):

Expansion of the alpha 2-adrenergic receptor family: cloning and characterization of a human alpha 2-adrenergic receptor subtype, the gene for which is located on chromosome 2. (PubMed id 2164221)^{2, 3, 4} Lomasney J.W.... Lefkowitz R.J. (1990)
Variation in the alpha2B-adrenergic receptor gene (ADRA2B) and its relationship to vascular response in vivo. (PubMed id 15900214)^{1, 3, 6} Muszkat M....Stein C.M. (2005)
Genetic variation at the human alpha2B-adrenergic receptor locus: role in blood pressure variation and yohimbine response. (PubMed id 15920038)^{1, 3, 6} Etzel J.P....Insel P.A. (2005)
Deletion polymorphism in the alpha2B-adrenergic receptor gene is associated with flow-mediated dilatation of the brachial artery. (PubMed id 12401126)^{1, 3, 6} Heinonen P....Scheinin M. (2002)
Alpha2B-adrenergic receptor deletion polymorphism and cardiac autonomic nervous system responses to exercise in obese women. (PubMed id 16247508)^{1, 3, 6} Ueno L.M....Negrao C.E. (2006)
Human response to alpha2-adrenergic agonist stimulation studied in an isolated vascular bed in vivo: Biphasic influence of dose, age, gender, and receptor genotype. (PubMed id 15900285)^{1, 3, 6} King D....O'Connor D.T. (2005)
Polymorphic deletion of three intracellular acidic residues of the alpha 2B-adrenergic receptor decreases G protein-coupled receptor kinase-mediated phosphorylation and desensitization. (PubMed id 11056163)^{1, 3, 4} Small K.M.... Liggett S.B. (2001)
Alpha2B adrenergic receptor 301-303 deletion polymorphism and vascular alpha2 adrenergic receptor response. (PubMed id 15864122)^{1, 3, 6} Muszkat M....Stein C.M. (2005)
Cloning, characterisation and identification of several polymorphisms in the promoter region of the human alpha2B-adrenergic receptor gene. (PubMed id 15037199)^{1, 3, 4} Cayla C.... Paris H. (2004)
Cloning, expression, and pharmacological characterization of a human alpha 2B-adrenergic receptor. (PubMed id 2172775)^{1, 3, 4} Weinshank R.L.... Hartig P.R. (1990)

(in PubMed, OMIM, and NCBI Bookshelf)
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		AND	OR
Aliases
Free Text

Query String		PubMed OMIM NCBI Bookshelf
	(Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, and/or H-InvDB)
About This Section

Entrez Gene: 151	HGNC: 282	AceView: ADRA2B	Ensembl:ENSG00000222040	euGenes: HUgn151
ECgene: ADRA2B	H-InvDB: ADRA2B

(According to HUGE)
About This Section

(According to ATLAS, HORDE, IMGT, MTDB, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section

Name	Description
SeattleSNPs	http://pga.gs.washington.edu/data/adra2b/

Licensable Technologies for ADRA2B
(Available from WIS Yeda, Salk, Tufts)

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(Reagents available from Applied Biosystems, Antibodies and assays by Cell Signaling Technology, Abcam, Novus Biologicals,
Sigma-Aldrich, R&D Systems, Millipore, Abnova, and/or Invitrogen, Clones available from OriGene,and/or Invitrogen, Drugs and/or compounds by Sigma-Aldrich,
Enzo Life Sciences, and/or Tocris Bioscience)
About This Section

Products for ADRA2B:

TaqMan ® Gene Expression Assays

TaqMan ® Genotyping Assays

Free SNP selection tool

Invitrogen iPath Pathways	Invitrogen BLOCK-iT™ RNAi
Invitrogen Antibodies	Invitrogen Assays
Invitrogen Clones	Invitrogen Q-PCR Products
Invitrogen Human Recombinant Kinases	Invitrogen Custom Antibody and Peptide Service
Invitrogen Proteins / Assays / Screening Services	Search Invitrogen catalog for ADRA2B-related products

	Millipore Custom Antibody & Bulk Services
	Millipore Preclinical / Clinical Development Services
	Millipore Immunoassay Services
	Millipore Target Screening & Profiling Services

	Predesigned and custom siRNAs for ADRA2B		Antibodies for ADRA2B
	Explore super-pooled esiRNAs		Browse proteins at Sigma-Aldrich
	Lentivirus-delivered shRNAs for ADRA2B		Small molecules for ADRA2B
	"Your Favorite Gene" Pathways		feedback

	Antibodies		Primer Pairs
	Cell Culture Products		ELISAs
	Flow Cytometry Kits		Protease Activity Assays & Reagents
	Cell Selection/Detection Kits & Reagents		ELISA/Assay Development Kits & Reagents
	Multiplex/Array Assay Kits & Reagents		ELISpot Kits & Development Modules
	Recombinant & Natural Proteins

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	Antibodies (alpha 2b Adrenergic Receptor)

Search OriGene for ADRA2B

Tocris compounds for ADRA2B

	Drugs for ADRA2B
	Search www.enzolifesicences.com for proteins, assays, substrates, inhibitors & antibodies

Search Novus for antibodies for ADRA2B

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ADRA2B Gene

protein-coding GIFtS: 59

Aliases &
Descriptions
for ADRA2B

Summaries
for ADRA2B

Genomic Location
for ADRA2B

Proteins
for ADRA2B

Protein Domains/
Families
for ADRA2B

Gene Function
for ADRA2B

Pathways & Interactions
for ADRA2B

Drugs & Compounds
for ADRA2B

Transcripts
for ADRA2B

Expression
for ADRA2B

Orthologs
for ADRA2B

Paralogs
for ADRA2B

SNPs/Variants
for ADRA2B

Disorders & Mutations
for ADRA2B

Medical News
for ADRA2B

Publications
for ADRA2B

Search for ADRA2B

Genome Databases showing ADRA2B

Other Databases showing ADRA2B

Specialized Databases showing ADRA2B

Licensable Technologies
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Services
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Gene Index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

ADRA2B Gene

protein-coding GIFtS: 59

Aliases & Descriptionsfor ADRA2B

Summariesfor ADRA2B

Genomic Locationfor ADRA2B

Proteinsfor ADRA2B

Protein Domains/Familiesfor ADRA2B

Gene Functionfor ADRA2B

Pathways & Interactionsfor ADRA2B

Drugs & Compoundsfor ADRA2B

Transcriptsfor ADRA2B

Expression for ADRA2B

Orthologsfor ADRA2B

Paralogsfor ADRA2B

SNPs/Variantsfor ADRA2B

Disorders & Mutationsfor ADRA2B

Medical Newsfor ADRA2B

Publicationsfor ADRA2B

Search for ADRA2B

Genome Databases showing ADRA2B

Other Databases showing ADRA2B

Specialized Databases showing ADRA2B

Licensable Technologiesfor ADRA2B

Servicesfor ADRA2B

Gene Index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

Aliases &
Descriptions
for ADRA2B

Summaries
for ADRA2B

Genomic Location
for ADRA2B

Proteins
for ADRA2B

Protein Domains/
Families
for ADRA2B

Gene Function
for ADRA2B

Pathways & Interactions
for ADRA2B

Drugs & Compounds
for ADRA2B

Transcripts
for ADRA2B

Expression
for ADRA2B

Orthologs
for ADRA2B

Paralogs
for ADRA2B

SNPs/Variants
for ADRA2B

Disorders & Mutations
for ADRA2B

Medical News
for ADRA2B

Publications
for ADRA2B

Licensable Technologies
for ADRA2B

Services
for ADRA2B