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Aliases for ADRA2B Gene

Aliases for ADRA2B Gene

  • Adrenoceptor Alpha 2B 2 3
  • ADRA2L1 3 4 6
  • Alpha-2 Adrenergic Receptor Subtype C2 3 4
  • Alpha-2B Adrenoreceptor 3 4
  • Alpha-2BAR 3 4
  • ADRA2RL1 3 4
  • ADRA2B Adrenergic, Alpha-2B-, Receptor 3
  • Alpha-2-Adrenergic Receptor-Like 1 3
  • Adrenergic, Alpha-2B-, Receptor 2
  • Alpha-2B Adrenergic Receptor 3
  • G-Protein Coupled Receptor 3
  • Alpha-2B Adrenoceptor 4
  • ALPHA2BAR 3
  • ADRARL1 3

External Ids for ADRA2B Gene

Previous HGNC Symbols for ADRA2B Gene

  • ADRA2L1
  • ADRA2RL1

Previous GeneCards Identifiers for ADRA2B Gene

  • GC02M094650
  • GC02M095232
  • GC02M096246
  • GC02M096263
  • GC02M096200
  • GC02M096142
  • GC02M096778
  • GC02M090739

Summaries for ADRA2B Gene

Entrez Gene Summary for ADRA2B Gene

  • This intronless gene encodes a seven-pass transmembrane protein. This protein is a member of a subfamily of G protein-coupled receptors that regulate neurotransmitter release from sympathetic nerves and from adrenergic neurons in the central nervous system. [provided by RefSeq, Apr 2014]

GeneCards Summary for ADRA2B Gene

ADRA2B (Adrenoceptor Alpha 2B) is a Protein Coding gene. Diseases associated with ADRA2B include benign adult familial myoclonic epilepsy and coronary restenosis. Among its related pathways are Signaling by GPCR and Activation of cAMP-Dependent PKA. GO annotations related to this gene include epinephrine binding and alpha2-adrenergic receptor activity.

UniProtKB/Swiss-Prot for ADRA2B Gene

  • Alpha-2 adrenergic receptors mediate the catecholamine-induced inhibition of adenylate cyclase through the action of G proteins. The rank order of potency for agonists of this receptor is clonidine > norepinephrine > epinephrine = oxymetazoline > dopamine > p-tyramine = phenylephrine > serotonin > p-synephrine / p-octopamine. For antagonists, the rank order is yohimbine > chlorpromazine > phentolamine > mianserine > spiperone > prazosin > alprenolol > propanolol > pindolol.

Tocris Summary for ADRA2B Gene

  • Adrenergic alpha2 receptors (alpha2-adrenoceptors) are members of the adrenergic receptor group of G-protein-coupled receptors that also includes alpha1A, alpha1B, alpha1D, beta1, beta2 and beta3. Adrenergic alpha2 receptors are divided into three subtypes: alpha2A, alpha2B and alpha2C, which are widely distributed in both the CNS and periphery. Alpha2-adrenoceptors play a role in the modulation of neurotransmission, smooth muscle contraction and thermoregulation. A fourth pharmacological subtype, alpha2D, has been identified in the rat which is thought to be a species ortholog of the human alpha2A subtype.

Gene Wiki entry for ADRA2B Gene

No data available for PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ADRA2B Gene

Genomics for ADRA2B Gene

Regulatory Elements for ADRA2B Gene

Genomic Location for ADRA2B Gene

Start:
96,112,875 bp from pter
End:
96,116,245 bp from pter
Size:
3,371 bases
Orientation:
Minus strand

Genomic View for ADRA2B Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for ADRA2B Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ADRA2B Gene

Proteins for ADRA2B Gene

  • Protein details for ADRA2B Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P18089-ADA2B_HUMAN
    Recommended name:
    Alpha-2B adrenergic receptor
    Protein Accession:
    P18089
    Secondary Accessions:
    • Q4TUH9
    • Q53RF2
    • Q9BZK0

    Protein attributes for ADRA2B Gene

    Size:
    447 amino acids
    Molecular mass:
    49566 Da
    Quaternary structure:
    • Interacts with RAB26.

    Three dimensional structures from OCA and Proteopedia for ADRA2B Gene

neXtProt entry for ADRA2B Gene

Proteomics data for ADRA2B Gene at MOPED

Post-translational modifications for ADRA2B Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for ADRA2B Gene

ENSEMBL proteins:
Reactome Protein details:
REFSEQ proteins:

No data available for DME Specific Peptides for ADRA2B Gene

Domains for ADRA2B Gene

Gene Families for ADRA2B Gene

HGNC:
  • ADRA :GPCR / Class A : Adrenoceptors : alpha
IUPHAR :

Suggested Antigen Peptide Sequences for ADRA2B Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

P18089

UniProtKB/Swiss-Prot:

ADA2B_HUMAN :
  • P18089
Family:
  • Belongs to the G-protein coupled receptor 1 family. Adrenergic receptor subfamily. ADRA2B sub-subfamily.
genes like me logo Genes that share domains with ADRA2B: view

Function for ADRA2B Gene

Molecular function for ADRA2B Gene

GENATLAS Biochemistry: adrenergic,alpha-2B-,receptor-like 1,G protein coupled receptor superfamily,inhibiting Ca2+ channels,contributing to the patho genesis of obesity
UniProtKB/Swiss-Prot Function: Alpha-2 adrenergic receptors mediate the catecholamine-induced inhibition of adenylate cyclase through the action of G proteins. The rank order of potency for agonists of this receptor is clonidine > norepinephrine > epinephrine = oxymetazoline > dopamine > p-tyramine = phenylephrine > serotonin > p-synephrine / p-octopamine. For antagonists, the rank order is yohimbine > chlorpromazine > phentolamine > mianserine > spiperone > prazosin > alprenolol > propanolol > pindolol.

Gene Ontology (GO) - Molecular Function for ADRA2B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004930 G-protein coupled receptor activity --
GO:0004935 adrenergic receptor activity --
GO:0004938 alpha2-adrenergic receptor activity IDA 17215105
GO:0005515 protein binding IPI 16531006
GO:0051379 epinephrine binding IDA 17215105
genes like me logo Genes that share ontologies with ADRA2B: view
genes like me logo Genes that share phenotypes with ADRA2B: view

Animal Models for ADRA2B Gene

MGI Knock Outs for ADRA2B:

No data available for Enzyme Numbers (IUBMB) , miRNA , Transcription Factor Targeting and HOMER Transcription for ADRA2B Gene

Localization for ADRA2B Gene

Subcellular locations from UniProtKB/Swiss-Prot for ADRA2B Gene

Cell membrane; Multi-pass membrane protein. Note=Interaction with RAB26 mediates transport from the Golgi to the cell membrane.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for ADRA2B Gene COMPARTMENTS Subcellular localization image for ADRA2B gene
Compartment Confidence
plasma membrane 5
endoplasmic reticulum 1
nucleus 1

Gene Ontology (GO) - Cellular Components for ADRA2B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005886 plasma membrane TAS --
GO:0005887 integral component of plasma membrane TAS 2164221
GO:0016021 integral component of membrane --
genes like me logo Genes that share ontologies with ADRA2B: view

Pathways for ADRA2B Gene

genes like me logo Genes that share pathways with ADRA2B: view

Interacting Proteins for ADRA2B Gene

Gene Ontology (GO) - Biological Process for ADRA2B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000165 MAPK cascade --
GO:0000187 activation of MAPK activity --
GO:0001525 angiogenesis --
GO:0003056 regulation of vascular smooth muscle contraction --
GO:0006940 regulation of smooth muscle contraction IEA --
genes like me logo Genes that share ontologies with ADRA2B: view

Compounds for ADRA2B Gene

(5) Tocris Compounds for ADRA2B Gene

Compound Action Cas Number
Atipamezole hydrochloride Selective alpha2 antagonist [104075-48-1]
BRL 44408 maleate Selective alpha2A antagonist [681806-46-2]
Dexmedetomidine hydrochloride Potent, highly selective alpha2 agonist. Active isomer of medetomidine (Cat. No. 2023) [145108-58-3]
Imiloxan hydrochloride Highly selective alpha2B antagonist [81167-22-8]
Yohimbine hydrochloride Selective alpha2 antagonist [65-19-0]

(6) HMDB Compounds for ADRA2B Gene

Compound Synonyms Cas Number PubMed IDs
Epinephrine
  • (-)-(R)-Epinephrine
51-43-4
Norepinephrine
  • (-)-(R)-Norepinephrine
51-41-2
Phenylephrine
  • Adrianol
59-42-7
p-Octopamine
  • (RS)-Octopamine
104-14-3
p-Synephrine
  • (+)-Synephrine
532-80-9

(35) Drugbank Compounds for ADRA2B Gene

Compound Synonyms Cas Number Type Actions PubMed IDs
Apomorphine
  • Apomorfin
41372-20-7 target agonist
Aripiprazole
  • OPC 31
129722-12-9 target antagonist
Asenapine
65576-45-6 target antagonist
Bethanidine
  • Betanidine
55-73-2 target agonist
Brimonidine
  • Brimonidine tartrate
59803-98-4 target agonist

(28) IUPHAR Ligand for ADRA2B Gene

Ligand Type Action Affinity Pubmed IDs
[3H]MK-912 Antagonist Antagonist 10.1
prazosin Antagonist Inverse agonist 9.9
WB 4101 Antagonist Antagonist 9.8
dexmedetomidine Agonist Full agonist 9.3
[3H]RX821002 Antagonist Antagonist 9.2
terguride Antagonist Antagonist 8.9
spiroxatrine Agonist Full agonist 8.8
RX821002 Antagonist Antagonist 8.7
roxindole Antagonist Antagonist 8.6
phentolamine Antagonist Antagonist 8.6
[3H]rauwolscine Antagonist Antagonist 8.4
ARC-239 Antagonist Antagonist 8.4
rauwolscine Antagonist Antagonist 8.4
clonidine Agonist Partial agonist 7.8
brimonidine Agonist Partial agonist 7.6
yohimbine Antagonist Antagonist 7.3
lisuride Agonist Partial agonist 7.2
oxymetazoline Agonist Full agonist 6.8
BRL 44408 Antagonist Antagonist 6.8
cabergoline Agonist Full agonist 6.7
pergolide Agonist Full agonist 6.5
bromocriptine Agonist Partial agonist 6.2
guanfacine Agonist Partial agonist 6.2
(plusmn)-adrenaline Agonist Full agonist 6.2
(-)-noradrenaline Agonist Full agonist 6
xylazine Agonist Partial agonist 5.9
apomorphine Activator Activation 5.1
chlorpromazine Channel blocker None

(7) Novoseek inferred chemical compound relationships for ADRA2B Gene

Compound -log(P) Hits PubMed IDs
yohimbine 50.4 2
epinephrine 37 2
nadh 17.1 2
sucrose 3.69 1
glutamate 0.372 1
genes like me logo Genes that share compounds with ADRA2B: view

Transcripts for ADRA2B Gene

mRNA/cDNA for ADRA2B Gene

(8) Selected AceView cDNA sequences:
(2) Additional mRNA sequences :
(1) REFSEQ mRNAs :
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for ADRA2B Gene

Adrenoceptor alpha 2B:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for ADRA2B Gene

No ASD Table

Relevant External Links for ADRA2B Gene

GeneLoc Exon Structure for
ADRA2B
ECgene alternative splicing isoforms for
ADRA2B

Expression for ADRA2B Gene

mRNA expression in normal human tissues for ADRA2B Gene

Integrated Proteomics: protein expression from ProteomicsDB and MOPED for ADRA2B Gene

SOURCE GeneReport for Unigene cluster for ADRA2B Gene Hs.247686

genes like me logo Genes that share expressions with ADRA2B: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for ADRA2B Gene

Orthologs for ADRA2B Gene

This gene was present in the common ancestor of animals.

Orthologs for ADRA2B Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia ADRA2B 35
  • 98.48 (n)
  • 97.32 (a)
cow
(Bos Taurus)
Mammalia ADRA2B 35
  • 87.72 (n)
  • 88.76 (a)
dog
(Canis familiaris)
Mammalia ADRA2B 35
  • 89.11 (n)
  • 90.77 (a)
mouse
(Mus musculus)
Mammalia Adra2b 35
  • 83.97 (n)
  • 83.45 (a)
Adra2b 16
rat
(Rattus norvegicus)
Mammalia Adra2b 35
  • 84.79 (n)
  • 84.79 (a)
chicken
(Gallus gallus)
Aves LOC101751513 35
  • 75.45 (n)
  • 73.03 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia adra2b 35
  • 60.48 (n)
  • 63.86 (a)
zebrafish
(Danio rerio)
Actinopterygii adra2b 35
  • 58.22 (n)
  • 57.08 (a)
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP000606 35
  • 57.28 (n)
  • 45.16 (a)
fruit fly
(Drosophila melanogaster)
Insecta CG7431 37
  • 46 (a)
CG18208 37
  • 44 (a)
worm
(Caenorhabditis elegans)
Secernentea dop-1 35
  • 47.49 (n)
  • 43.63 (a)
Species with no ortholog for ADRA2B:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for ADRA2B Gene

ENSEMBL:
Gene Tree for ADRA2B (if available)
TreeFam:
Gene Tree for ADRA2B (if available)

Paralogs for ADRA2B Gene

Selected SIMAP similar genes for ADRA2B Gene using alignment to 3 proteins:

genes like me logo Genes that share paralogs with ADRA2B: view

No data available for Paralogs for ADRA2B Gene

Variants for ADRA2B Gene

Polymorphic Variants from UniProtKB/Swiss-Prot for ADRA2B Gene

P18089-ADA2B_HUMAN
A rare polymorphic frameshift in position 448 produces a protein of 542 residues

Sequence variations from dbSNP and Humsavar for ADRA2B Gene

SNP ID Clin Chr 02 pos Sequence Context AA Info Type MAF
rs2229169 -- 96,114,968(-) CTGGG(A/C)GCCAT reference, synonymous-codon
rs2252697 -- 96,112,442(+) ACCCG(C/G)GGCTA downstream-variant-500B
rs2692896 -- 96,117,748(-) CAGGG(C/G)TGCCC upstream-variant-2KB
rs2692897 -- 96,117,374(-) TGTGC(A/C)CCGTA upstream-variant-2KB
rs2733968 -- 96,117,748(-) TCAGG(C/G)GTGCC upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for ADRA2B Gene

Variant ID Type Subtype PubMed ID
dgv650e201 CNV Deletion 23290073
esv5003 CNV Complex 18987735
dgv4247n71 CNV Loss 21882294
dgv4248n71 CNV Loss 21882294
nsv874677 CNV Loss 21882294
nsv2834 CNV Loss 18451855
nsv874678 CNV Loss 21882294

Relevant External Links for ADRA2B Gene

HapMap Linkage Disequilibrium report
ADRA2B
Human Gene Mutation Database (HGMD)
ADRA2B

Disorders for ADRA2B Gene

(5) Novoseek inferred disease relationships for ADRA2B Gene

Disease -log(P) Hits PubMed IDs
resting heart rate 45.4 1
essential hypertension 26.7 1
glioma 5.89 1
myocardial infarction 0 1
breast cancer 0 2

Relevant External Links for ADRA2B

Genetic Association Database (GAD)
ADRA2B
Human Genome Epidemiology (HuGE) Navigator
ADRA2B
genes like me logo Genes that share disorders with ADRA2B: view

No data available for UniProtKB/Swiss-Prot for ADRA2B Gene

Publications for ADRA2B Gene

  1. Cloning, expression, and pharmacological characterization of a human alpha 2B-adrenergic receptor. (PMID: 2172775) Weinshank R.L. … Hartig P.R. (Mol. Pharmacol. 1990) 3 4 23
  2. Polymorphic deletion of three intracellular acidic residues of the alpha 2B-adrenergic receptor decreases G protein-coupled receptor kinase-mediated phosphorylation and desensitization. (PMID: 11056163) Small K.M. … Liggett S.B. (J. Biol. Chem. 2001) 3 4 23
  3. Deletion polymorphism in the alpha2B-adrenergic receptor gene is associated with flow-mediated dilatation of the brachial artery. (PMID: 12401126) Heinonen P. … Scheinin M. (Clin. Sci. 2002) 3 23 48
  4. Cloning, characterisation and identification of several polymorphisms in the promoter region of the human alpha2B-adrenergic receptor gene. (PMID: 15037199) Cayla C. … Paris H. (Biochem. Pharmacol. 2004) 3 4 23
  5. Alpha2B adrenergic receptor 301-303 deletion polymorphism and vascular alpha2 adrenergic receptor response. (PMID: 15864122) Muszkat M. … Stein C.M. (Pharmacogenet. Genomics 2005) 3 23 48

Products for ADRA2B Gene

  • antibodies-online peptides for ADRA2B
  • antibodies-online antibodies for ADRA2B
  • antibodies-online kits for ADRA2B

Sources for ADRA2B Gene

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