Aliases for ADRA2B Gene
External Ids for ADRA2B Gene
Previous HGNC Symbols for ADRA2B Gene
Previous GeneCards Identifiers for ADRA2B Gene
This intronless gene encodes a seven-pass transmembrane protein. This protein is a member of a subfamily of G protein-coupled receptors that regulate neurotransmitter release from sympathetic nerves and from adrenergic neurons in the central nervous system. [provided by RefSeq, Apr 2014]
GeneCards Summary for ADRA2B Gene
ADRA2B (Adrenoceptor Alpha 2B) is a Protein Coding gene. Diseases associated with ADRA2B include benign adult familial myoclonic epilepsy and coronary restenosis. Among its related pathways are Signaling by GPCR and Activation of cAMP-Dependent PKA. GO annotations related to this gene include epinephrine binding and alpha2-adrenergic receptor activity.
UniProtKB/Swiss-Prot for ADRA2B Gene
Alpha-2 adrenergic receptors mediate the catecholamine-induced inhibition of adenylate cyclase through the action of G proteins. The rank order of potency for agonists of this receptor is clonidine > norepinephrine > epinephrine = oxymetazoline > dopamine > p-tyramine = phenylephrine > serotonin > p-synephrine / p-octopamine. For antagonists, the rank order is yohimbine > chlorpromazine > phentolamine > mianserine > spiperone > prazosin > alprenolol > propanolol > pindolol.
Adrenergic alpha2 receptors (alpha2-adrenoceptors) are members of the adrenergic receptor group of G-protein-coupled receptors that also includes alpha1A, alpha1B, alpha1D, beta1, beta2 and beta3. Adrenergic alpha2 receptors are divided into three subtypes: alpha2A, alpha2B and alpha2C, which are widely distributed in both the CNS and periphery. Alpha2-adrenoceptors play a role in the modulation of neurotransmission, smooth muscle contraction and thermoregulation. A fourth pharmacological subtype, alpha2D, has been identified in the rat which is thought to be a species ortholog of the human alpha2A subtype.