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Aliases for ADRA2A Gene

Aliases for ADRA2A Gene

  • Adrenoceptor Alpha 2A 2 3 5
  • Alpha-2 Adrenergic Receptor Subtype C10 3 4
  • Adrenergic, Alpha-2A-, Receptor 2 3
  • Alpha-2A Adrenoreceptor 3 4
  • Alpha-2AAR Subtype C10 2 3
  • Alpha-2A Adrenoceptor 3 4
  • ADRA2R 3 4
  • ADRAR 3 4
  • Alpha-2-Adrenergic Receptor, Platelet Type 3
  • Alpha-2A-Adrenergic Receptor 2
  • Alpha-2A Adrenergic Receptor 3
  • Alpha-2AAR 4
  • ZNF32 3
  • ADRA2 3

External Ids for ADRA2A Gene

Previous HGNC Symbols for ADRA2A Gene

  • ADRA2
  • ADRA2R

Previous GeneCards Identifiers for ADRA2A Gene

  • GC10P111730
  • GC10P112070
  • GC10P112968
  • GC10P112501
  • GC10P112826
  • GC10P106465

Summaries for ADRA2A Gene

Entrez Gene Summary for ADRA2A Gene

  • Alpha-2-adrenergic receptors are members of the G protein-coupled receptor superfamily. They include 3 highly homologous subtypes: alpha2A, alpha2B, and alpha2C. These receptors have a critical role in regulating neurotransmitter release from sympathetic nerves and from adrenergic neurons in the central nervous system. Studies in mouse revealed that both the alpha2A and alpha2C subtypes were required for normal presynaptic control of transmitter release from sympathetic nerves in the heart and from central noradrenergic neurons; the alpha2A subtype inhibited transmitter release at high stimulation frequencies, whereas the alpha2C subtype modulated neurotransmission at lower levels of nerve activity. This gene encodes alpha2A subtype and it contains no introns in either its coding or untranslated sequences. [provided by RefSeq, Jul 2008]

GeneCards Summary for ADRA2A Gene

ADRA2A (Adrenoceptor Alpha 2A) is a Protein Coding gene. Diseases associated with ADRA2A include Adra2a-Related Altered Drug Metabolism and Horner's Syndrome. Among its related pathways are Signaling by GPCR and Peptide ligand-binding receptors. GO annotations related to this gene include G-protein coupled receptor activity and protein heterodimerization activity. An important paralog of this gene is ADRA2C.

UniProtKB/Swiss-Prot for ADRA2A Gene

  • Alpha-2 adrenergic receptors mediate the catecholamine-induced inhibition of adenylate cyclase through the action of G proteins. The rank order of potency for agonists of this receptor is oxymetazoline > clonidine > epinephrine > norepinephrine > phenylephrine > dopamine > p-synephrine > p-tyramine > serotonin = p-octopamine. For antagonists, the rank order is yohimbine > phentolamine = mianserine > chlorpromazine = spiperone = prazosin > propanolol > alprenolol = pindolol.

Tocris Summary for ADRA2A Gene

  • Adrenergic alpha2 receptors (alpha2-adrenoceptors) are members of the adrenergic receptor group of G-protein-coupled receptors that also includes alpha1A, alpha1B, alpha1D, beta1, beta2 and beta3. Adrenergic alpha2 receptors are divided into three subtypes in humans: alpha2A, alpha2B and alpha2C.

Gene Wiki entry for ADRA2A Gene

No data available for PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ADRA2A Gene

Genomics for ADRA2A Gene

Regulatory Elements for ADRA2A Gene

Enhancers for ADRA2A Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH10F110930 0.4 Ensembl 22.6 -145.1 -145132 2.2 ZNF493 ZFP64 ZNF121 ZNF354C FOS ZNF202 ZNF680 ZNF654 ZBTB11 REST SMC3 SMNDC1 ENSG00000270589 ADRA2A BBIP1 MIR4680 PDCD4 ENSG00000232470 RPL13AP6 SHOC2
GH10F111200 0.4 ENCODE 12.3 +123.9 123946 0.1 POLR2A ZNF18 ADRA2A GC10P111105 BTBD7P2
GH10F111102 0.2 ENCODE 12 +26.5 26539 1.4 ZNF23 EGR2 ADRA2A ENSG00000270589 LOC724065 PIR58551
GH10F111136 0.2 ENCODE 11.7 +60.1 60147 1.8 SOX13 ZNF146 TEAD4 ZMYM3 ZNF644 RAD21 YY1 RARA ZNF416 HNF4G ADRA2A SMC3 BBIP1 GC10P111105 BTBD7P2
GH10F110928 0.6 Ensembl 11.5 -148.1 -148132 1.8 ZNF202 ZNF263 CTCF PKNOX1 KLF1 FEZF1 RAD21 GLIS1 CEBPA SMC3 SMC3 ADRA2A PDCD4 MIR4680 ENSG00000270589 ENSG00000232470 RPL13AP6 SHOC2
- Elite enhancer/Elite enhancer-gene association Download Table
Download GeneHancer data dump

Enhancers around ADRA2A on UCSC Golden Path with GeneCards custom track

Promoters for ADRA2A Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00001764082 -32 2001 INSM2 KLF17 ZNF2 RAD21 ZEB1 YY1 RARA GLIS2 ZNF366 ZNF548

Genomic Location for ADRA2A Gene

111,077,032 bp from pter
111,080,907 bp from pter
3,876 bases
Plus strand

Genomic View for ADRA2A Gene

Genes around ADRA2A on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ADRA2A Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ADRA2A Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ADRA2A Gene

Proteins for ADRA2A Gene

  • Protein details for ADRA2A Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Alpha-2A adrenergic receptor
    Protein Accession:
    Secondary Accessions:
    • B0LPF6
    • Q2I8G2
    • Q2XN99
    • Q86TH8
    • Q9BZK1

    Protein attributes for ADRA2A Gene

    450 amino acids
    Molecular mass:
    48957 Da
    Quaternary structure:
    No Data Available

    Three dimensional structures from OCA and Proteopedia for ADRA2A Gene

neXtProt entry for ADRA2A Gene

Post-translational modifications for ADRA2A Gene

  • Glycosylation at Asn 10 and Asn 14
  • Modification sites at PhosphoSitePlus

Other Protein References for ADRA2A Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for ADRA2A Gene

Domains & Families for ADRA2A Gene

Gene Families for ADRA2A Gene

Suggested Antigen Peptide Sequences for ADRA2A Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the G-protein coupled receptor 1 family. Adrenergic receptor subfamily. ADRA2A sub-subfamily.
  • Belongs to the G-protein coupled receptor 1 family. Adrenergic receptor subfamily. ADRA2A sub-subfamily.
genes like me logo Genes that share domains with ADRA2A: view

Function for ADRA2A Gene

Molecular function for ADRA2A Gene

GENATLAS Biochemistry:
adrenergic,alpha-2A-,receptor,G protein coupled receptor superfamily,inhibiting formation of cAMP opening K+ channels,inhibiting Ca2+ channels
UniProtKB/Swiss-Prot Function:
Alpha-2 adrenergic receptors mediate the catecholamine-induced inhibition of adenylate cyclase through the action of G proteins. The rank order of potency for agonists of this receptor is oxymetazoline > clonidine > epinephrine > norepinephrine > phenylephrine > dopamine > p-synephrine > p-tyramine > serotonin = p-octopamine. For antagonists, the rank order is yohimbine > phentolamine = mianserine > chlorpromazine = spiperone = prazosin > propanolol > alprenolol = pindolol.

Gene Ontology (GO) - Molecular Function for ADRA2A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004871 signal transducer activity IEA --
GO:0004930 G-protein coupled receptor activity IEA --
GO:0004935 adrenergic receptor activity IEA --
GO:0004938 alpha2-adrenergic receptor activity IEA,ISS 1354394
GO:0005515 protein binding IPI 16531006
genes like me logo Genes that share ontologies with ADRA2A: view
genes like me logo Genes that share phenotypes with ADRA2A: view

Animal Models for ADRA2A Gene

MGI Knock Outs for ADRA2A:

Animal Model Products

miRNA for ADRA2A Gene

miRTarBase miRNAs that target ADRA2A

Inhibitory RNA Products

Clone Products

  • R&D Systems cDNA Clones for ADRA2A (alpha-2A Adrenergic R/ADRA2A)

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for ADRA2A Gene

Localization for ADRA2A Gene

Subcellular locations from UniProtKB/Swiss-Prot for ADRA2A Gene

Cell membrane; Multi-pass membrane protein.

Subcellular locations from

Jensen Localization Image for ADRA2A Gene COMPARTMENTS Subcellular localization image for ADRA2A gene
Compartment Confidence
plasma membrane 5
endoplasmic reticulum 1
nucleus 1

Gene Ontology (GO) - Cellular Components for ADRA2A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm IDA 19477270
GO:0005886 plasma membrane IEA,TAS --
GO:0005887 integral component of plasma membrane IDA 2823383
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with ADRA2A: view

Pathways & Interactions for ADRA2A Gene

genes like me logo Genes that share pathways with ADRA2A: view

Gene Ontology (GO) - Biological Process for ADRA2A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001819 positive regulation of cytokine production IDA 17655843
GO:0006928 movement of cell or subcellular component TAS 9624180
GO:0006940 regulation of smooth muscle contraction IEA --
GO:0007165 signal transduction IEA,TAS 2823383
GO:0007186 G-protein coupled receptor signaling pathway IEA,ISS 19965390
genes like me logo Genes that share ontologies with ADRA2A: view

No data available for SIGNOR curated interactions for ADRA2A Gene

Drugs & Compounds for ADRA2A Gene

(237) Drugs for ADRA2A Gene - From: DrugBank, PharmGKB, ClinicalTrials, ApexBio, DGIdb, IUPHAR, HMDB, Tocris, and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Dexmedetomidine Approved, Vet_approved Pharma Partial agonist, Agonist, agonist, Target 540
Guanfacine Approved, Investigational Pharma Partial agonist, Agonist, agonist, Target 56
Oxymetazoline Approved Pharma Full agonist, Agonist, agonist, Target 440
Norepinephrine Approved Pharma stimulator, Target, agonist 683
Prazosin Approved Pharma Inverse agonist, Antagonist, antagonist, Target, binder 62

(15) Additional Compounds for ADRA2A Gene - From: Novoseek, HMDB, IUPHAR, and Tocris

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
Negative, Allosteric regulator
  • (RS)-Octopamine
  • 1-(p-Hydroxyphenyl)-2-aminoethanol
  • 2-Amino-1-(4-hydroxyphenyl)ethanol
  • 4-Hydroxyphenethanolamine
  • 4-[2-Amino-1-hydroxyethyl]phenol
Medetomidine hydrochloride

(5) Tocris Compounds for ADRA2A Gene

Compound Action Cas Number
Atipamezole hydrochloride Selective alpha2 antagonist 104075-48-1
BRL 44408 maleate Selective alpha2A antagonist 681806-46-2
Imiloxan hydrochloride Highly selective alpha2B antagonist 81167-22-8
Medetomidine hydrochloride Potent, highly selective alpha2 agonist 86347-15-1
RS 79948 hydrochloride Potent, selective alpha2 antagonist 186002-54-0

(127) ApexBio Compounds for ADRA2A Gene

Compound Action Cas Number
(R)-(-)-Niguldipine hydrochloride
(R)-(+)-m-Nitrobiphenyline oxalate 945618-97-3
(S)-(-)-Atenolol 93379-54-5
(S)-(-)-Pindolol 26328-11-0
(S)-(-)-Propranolol hydrochloride 4199-10-4
(S)-(+)-Niguldipine hydrochloride 113145-69-0
2-PMDQ 139047-55-5
3-MPPI 133399-65-2
A 80426 mesylate α2-adrenoceptor antagonist and 5-HT uptake inhibitor 152148-64-6
Acebutolol HCl 34381-68-5
Adrenalone HCl 62-13-5
Agmatine sulfate 2482-00-0
Alfuzosin 81403-80-7
Alfuzosin HCl α1 adrenoceptor antagonist,functionally uro-selective 81403-68-1
Alprenolol hydrochloride 13707-88-5
Atipamezole hydrochloride 104075-48-1
Bambuterol 81732-65-2
Betaxolol βadrenergic receptor blocker 659-18-7
Betaxolol HCl 63659-19-8
B-HT 933 dihydrochloride α2-adrenoceptor agonist 36067-72-8
Bisoprolol fumarate 104344-23-2
Brimonidine Tartrate 70359-46-5
BRL 44408 maleate Selective α2A-AR antagonist 681806-46-2
Bucindolol 71119-11-4
Carvedilol 72956-09-3
Cimaterol 54239-37-1
Cirazoline hydrochloride 40600-13-3
Cisatracurium Besylate Neuromuscular-blocking drug 96946-42-8
Clonidine HCl 4205-91-8
Detomidine 76631-46-4
Detomidine HCl 90038-01-0
Dexmedetomidine 113775-47-6
Dexmedetomidine HCl 145108-58-3
Dihydroergocristine mesylate 24730-10-7
DL-Adrenaline 329-65-7
Dobutamine hydrochloride 49745-95-1
Doxazosin 74191-85-8
Doxazosin Mesylate α1-adrenergic receptor antagonist 77883-43-3
Droxidopa 23651-95-8
DSP-4 40616-75-9
Efaroxan hydrochloride 89197-00-2
Epinephrine Bitartrate 51-42-3
Epinephrine HCl 55-31-2
Formoterol Hemifumarate 43229-80-7
Guanabenz Acetate 23256-50-0
Guanfacine 29110-47-2
Guanfacine hydrochloride α2A-adrenoceptor agonist 29110-48-3
HEAT hydrochloride 30007-39-7
ICI 215,001 hydrochloride 140850-02-8
ICI 89406 53671-71-9
Idazoxan hydrochloride 79944-56-2
Imiloxan hydrochloride 81167-22-8
Indacaterol Maleate 753498-25-8
Isoprenaline HCl 51-30-9
Ivabradine HCl 148849-67-6
JP 1302 dihydrochloride 1259314-65-2
L-(-)-α-Methyldopa hydrochloride Alpha-adrenergic agonist 884-39-9
L-748,337 244192-94-7
Labetalol HCl 32780-64-6
L-Adrenaline 51-43-4
Levalbuterol tartrate 661464-94-4
Maprotiline HCl 10347-81-6
Medetomidine α2-adrenoceptor agonist 86347-14-0
Medetomidine HCl 86347-15-1
Methyldopa 555-30-6
Metoprolol Succinate 98418-47-4
Metoprolol Tartrate β1-adrenergic blocking agent 392-17-7
Mirabegron (YM178) 223673-61-8
Moxonidine I1R/α2AR agonist 75438-57-2
Moxonidine hydrochloride α2AR/I1R agonist 75536-04-8
Naftopidil α1-adrenergic receptor antagonist 57149-07-2
Naftopidil DiHCl 57149-08-3
Naphazoline HCl 550-99-2
Nebivolol 152520-56-4
Nedaplatin 95734-82-0
Noradrenaline bitartrate monohydrate 108341-18-0
NPEC-caged-noradrenalin 1257323-83-3
Oxprenolol hydrochloride 6452-73-9
Oxymetazoline HCl Alpha-1/alpha-2 agonist 2315-02-8
Phenoxybenzamine HCl 63-92-3
Phentolamine Mesylate Alpha 1/2-blocking agent 65-28-1
Phenylephrine HCl 61-76-7
Pindolol 13523-86-9
Prazosin 19216-56-9
Prazosin HCl α1 and α2B-adrenoceptor antagonist 19237-84-4
Procaterol hydrochloride 62929-91-3
Pronethalol hydrochloride 1951-02-5
Propranolol HCl 318-98-9
Rauwolscine hydrochloride 6211-32-1
Rec 15/2615 dihydrochloride 173059-17-1
Ritodrine HCl β-2 adrenergic receptor agonist 23239-51-2
RS 100329 hydrochloride 1215654-26-4
RS 79948 hydrochloride 186002-54-0
RWJ 52353 245744-10-9
RX 821002 hydrochloride 109544-45-8
Salbutamol Sulfate β-2 adrenergic receptor agonist 51022-70-9
Salmefamol 18910-65-1
Salmeterol xinafoate β2-adrenergic receptor agonist 94749-08-3
Scopine 498-45-3
SDZ 21009 39731-05-0
Setiptiline Serotonin receptor antagonist 57262-94-9
Silodosin α1-adrenoceptor antagonist 160970-54-7
SKF 86466 hydrochloride 86129-54-6
SNAP 5089 157066-77-8
Sotalol 959-24-0
Spiroxatrine 1054-88-2
SR 58611A hydrochloride 121524-09-2
SR 59230A hydrochloride 1135278-41-9
ST 91 4749-61-5
Synephrine 1994-07-5
Synephrine HCl 5985-28-4
TC-G 1000 245744-18-7
Terazosin HCl 70024-40-7
Terbutaline Sulfate 23031-32-5
Tetrahydrozoline HCl 522-48-5
Timolol Maleate 26921-17-5
Tizanidine 51322-75-9
Tizanidine HCl 64461-82-1
Tolazoline HCl 59-97-2
WB 4101 hydrochloride 2170-58-3
Xamoterol hemifumarate 73210-73-8
Xylazine α2-adrenoceptor agonist 7361-61-7
Xylazine HCl α2 Adrenoceptor agonist 23076-35-9
Xylometazoline HCl 1218-35-5
ZD 2079 178600-17-4
ZD 7114 hydrochloride 129689-28-7
Zinterol hydrochloride 37000-20-7
genes like me logo Genes that share compounds with ADRA2A: view

Transcripts for ADRA2A Gene

mRNA/cDNA for ADRA2A Gene

(1) REFSEQ mRNAs :
(3) Additional mRNA sequences :
(70) Selected AceView cDNA sequences:
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for ADRA2A Gene

Adrenoceptor alpha 2A:
Representative Sequences:

Inhibitory RNA Products

Clone Products

  • R&D Systems cDNA Clones for ADRA2A (alpha-2A Adrenergic R/ADRA2A)

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for ADRA2A Gene

No ASD Table

Relevant External Links for ADRA2A Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for ADRA2A Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for ADRA2A Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for ADRA2A Gene

This gene is overexpressed in Cervix - Endocervix (x6.3), Adipose - Subcutaneous (x5.9), and Cervix - Ectocervix (x5.6).

Protein differential expression in normal tissues from HIPED for ADRA2A Gene

This gene is overexpressed in Fetal Brain (39.4), Peripheral blood mononuclear cells (16.4), and Adipocyte (7.8).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for ADRA2A Gene

Protein tissue co-expression partners for ADRA2A Gene

NURSA nuclear receptor signaling pathways regulating expression of ADRA2A Gene:


SOURCE GeneReport for Unigene cluster for ADRA2A Gene:

genes like me logo Genes that share expression patterns with ADRA2A: view

Primer Products

No data available for mRNA Expression by UniProt/SwissProt for ADRA2A Gene

Orthologs for ADRA2A Gene

This gene was present in the common ancestor of animals.

Orthologs for ADRA2A Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia ADRA2A 34 35
  • 99.28 (n)
(Canis familiaris)
Mammalia ADRA2A 35
  • 92 (a)
(Bos Taurus)
Mammalia ADRA2A 34
  • 89.9 (n)
(Rattus norvegicus)
Mammalia Adra2a 34
  • 89.03 (n)
(Mus musculus)
Mammalia Adra2a 34 16 35
  • 88.03 (n)
(Monodelphis domestica)
Mammalia ADRA2A 35
  • 87 (a)
(Gallus gallus)
Aves ADRA2A 34 35
  • 75.57 (n)
(Anolis carolinensis)
Reptilia ADRA2A 35
  • 69 (a)
(Danio rerio)
Actinopterygii adra2a 34 35
  • 65.28 (n)
fruit fly
(Drosophila melanogaster)
Insecta CG18208 36 34 35
  • 57.2 (n)
DopR2 36
  • 44 (a)
Oct-TyrR 35
  • 25 (a)
(Caenorhabditis elegans)
Secernentea octr-1 34 35
  • 47.13 (n)
F14D12.6 36
  • 42 (a)
ser-2 35
  • 30 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 35
  • 29 (a)
Species where no ortholog for ADRA2A was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)

Evolution for ADRA2A Gene

Gene Tree for ADRA2A (if available)
Gene Tree for ADRA2A (if available)

Paralogs for ADRA2A Gene

(3) SIMAP similar genes for ADRA2A Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with ADRA2A: view

Variants for ADRA2A Gene

Sequence variations from dbSNP and Humsavar for ADRA2A Gene

SNP ID Clin Chr 10 pos Sequence Context AA Info Type
rs111623406 -- 111,079,433(+) ACTGC(A/T)GGCAG utr-variant-3-prime
rs111872241 -- 111,078,116(+) CGGGC(A/C)ACCCC reference, synonymous-codon
rs11195418 -- 111,075,401(+) GGGCT(A/G)TAGAC upstream-variant-2KB
rs11195419 -- 111,079,610(+) TTTGG(A/C)CACTC utr-variant-3-prime
rs11195420 -- 111,081,226(+) AGAGG(G/T)GTCTA downstream-variant-500B

Structural Variations from Database of Genomic Variants (DGV) for ADRA2A Gene

Variant ID Type Subtype PubMed ID
nsv527400 CNV loss 19592680
nsv7211 OTHER inversion 18451855
nsv7549 CNV insertion 18451855
nsv825566 CNV gain 20364138

Variation tolerance for ADRA2A Gene

Residual Variation Intolerance Score: 62.8% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 3.09; 50.85% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for ADRA2A Gene

Human Gene Mutation Database (HGMD)
SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ADRA2A Gene

Disorders for ADRA2A Gene

MalaCards: The human disease database

(8) MalaCards diseases for ADRA2A Gene - From: GeneTests, DISEASES, Novoseek, and GeneCards

Disorder Aliases PubMed IDs
adra2a-related altered drug metabolism
horner's syndrome
  • bernard horner syndrome
gilles de la tourette syndrome
  • tourette syndrome
attention deficit-hyperactivity disorder
  • attention deficit hyperactivity disorder
motion sickness
  • motion sickness nos
- elite association - COSMIC cancer census association via MalaCards

Relevant External Links for ADRA2A

Genetic Association Database (GAD)
Human Genome Epidemiology (HuGE) Navigator
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
genes like me logo Genes that share disorders with ADRA2A: view

No data available for UniProtKB/Swiss-Prot and Genatlas for ADRA2A Gene

Publications for ADRA2A Gene

  1. New genetic loci implicated in fasting glucose homeostasis and their impact on type 2 diabetes risk. (PMID: 20081858) Dupuis J. … Barroso I. (Nat. Genet. 2010) 3 22 46 64
  2. A preliminary candidate genotype-intermediate phenotype study of satiation and gastric motor function in obesity. (PMID: 19876010) Papathanasopoulos A. … Zinsmeister A.R. (Obesity (Silver Spring) 2010) 3 22 46 64
  3. Effect of alpha2A-adrenoceptor C-1291G genotype and maltreatment on hyperactivity and inattention in adolescents. (PMID: 19922756) Kiive E. … Harro J. (Prog. Neuropsychopharmacol. Biol. Psychiatry 2010) 3 22 46 64
  4. Association between homozygosity of a G allele of the alpha-2a-adrenergic receptor gene and methylphenidate response in Korean children and adolescents with attention-deficit/hyperactivity disorder. (PMID: 19150055) Cheon K.A. … Namkoong K. (Biol. Psychiatry 2009) 3 22 46 64
  5. Association of the adrenergic alpha 2a receptor--1291C/G polymorphism with weight change and treatment response to mirtazapine in patients with major depressive disorder. (PMID: 19401164) Lee H.Y. … Lee M.S. (Brain Res. 2009) 3 22 46 64

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