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Category Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21

GIFtS
-

ADRA2A Gene

protein-coding GIFtS: 66
GCID: GC10P112826

adrenoceptor alpha 2A

(Previous names: adrenergic, alpha-2A-, receptor )
(Previous symbols: ADRA2, ADRA2R)

Explore 41 diseases affiliated with
ADRA2A via

MalaCards

our new
Human Malady Compendium

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc, ⁷Ensembl, ⁸DME, ⁹miRBase, and/or ¹⁰fRNAdb)
About This Section

Aliases
Adrenoceptor Alpha 2A¹ ²		Alpha-2A Adrenoreceptor² ³
ADRA2R¹ ² ³ ⁵		ALPHA2AAR²
ADRAR¹ ² ³		ZNF32²
ADRA2¹ ²		Alpha-2-Adrenergic Receptor, Platelet Type²
Adrenergic, Alpha-2A-, Receptor¹ ²		Alpha-2A Adrenergic Receptor²
Alpha-2 Adrenergic Receptor Subtype C10² ³		Alpha-2AAR Subtype C10²
Alpha-2A Adrenoceptor² ³		Alpha-2AAR³

External Ids:	HGNC: 281¹	Entrez Gene: 150²	Ensembl: ENSG00000150594⁷	OMIM: 104210⁵	UniProtKB: P08913³

Export aliases for ADRA2A gene to outside databases

Previous GC identifers: GC10P111730 GC10P112070 GC10P112968 GC10P112501 GC10P106465

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for ADRA2A:

Alpha-2-adrenergic receptors are members of the G protein-coupled receptor superfamily. They include 3 highly

homologous subtypes: alpha2A, alpha2B, and alpha2C. These receptors have a critical role in regulating

neurotransmitter release from sympathetic nerves and from adrenergic neurons in the central nervous system. Studies in

mouse revealed that both the alpha2A and alpha2C subtypes were required for normal presynaptic control of transmitter

release from sympathetic nerves in the heart and from central noradrenergic neurons; the alpha2A subtype inhibited

transmitter release at high stimulation frequencies, whereas the alpha2C subtype modulated neurotransmission at lower

levels of nerve activity. This gene encodes alpha2A subtype and it contains no introns in either its coding or

untranslated sequences. (provided by RefSeq, Jul 2008)

UniProtKB/Swiss-Prot: ADA2A_HUMAN, P08913

Function: Alpha-2 adrenergic receptors mediate the catecholamine-induced inhibition of adenylate cyclase through the

action of G proteins. The rank order of potency for agonists of this receptor is oxymetazoline > clonidine >

epinephrine > norepinephrine > phenylephrine > dopamine > p-synephrine > p-tyramine > serotonin = p-octopamine. For

antagonists, the rank order is yohimbine > phentolamine = mianserine > chlorpromazine = spiperone = prazosin >

propanolol > alprenolol = pindolol

summary for ADRA2A:

Adrenergic alpha2 receptors (alpha2-adrenoceptors) are members of the adrenergic receptor group of

G-protein-coupled receptors that also includes alpha1A, alpha1B, alpha1D, beta1, beta2 and beta3. Adrenergic

alpha2 receptors are divided into three subtypes: alpha2A, alpha2B and alpha2C, which are widely distributed

in both the CNS and periphery. Alpha2-adrenoceptors play a role in the modulation of neurotransmission,

smooth muscle contraction and thermoregulation. A fourth pharmacological subtype, alpha2D, has been

identified in the rat which is thought to be a species ortholog of the human alpha2A subtype.

Gene Wiki entry for ADRA2A (Alpha-2A adrenergic receptor)

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section

RefSeq DNA sequence:

NC_000010.10 NC_018921.1 NT_030059.13

Regulatory elements:

SABiosciences Regulatory transcription factor binding sites in the ADRA2A gene promoter:
Max1 Bach1 E47 Arnt AREB6 E2F E2F-1 c-Myc
Other transcription factors

SwitchGear Promoter luciferase reporter plasmids (see all 2): ADRA2A promoter sequence

Search SABiosciences Chromatin IP Primers for ADRA2A

Epigenetics:

QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat ADRA2A

Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 10q25.2 Ensembl cytogenetic band: 10q25.2 HGNC cytogenetic band: 10q25.2

ADRA2A Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
ADRA2A gene location

GeneLoc information about chromosome 10 GeneLoc Exon Structure

GeneLoc location for GC10P112826: view genomic region (about GC identifiers)

Start:	112,836,790 bp from pter	End:	112,840,665 bp from pter
Size:	3,876 bases	Orientation:	plus strand

(According to ¹UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to ²PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section

UniProtKB/Swiss-Prot: ADA2A_HUMAN, P08913 (See protein sequence)

Recommended Name: Alpha-2A adrenergic receptor

Size: 450 amino acids; 48957 Da

Subcellular location: Cell membrane; Multi-pass membrane protein

4 PDB 3D structures from and Proteopedia for ADRA2A:

1HLL (3D)

1HO9 (3D)

1HOD (3D)

1HOF (3D)

Secondary accessions: B0LPF6 Q2I8G2 Q2XN99 Q86TH8 Q9BZK1

Explore the universe of human proteins at neXtProt for ADRA2A: NX_P08913

Post-translational modifications:

View modification sites using PhosphoSitePlus²

View neXtProt modification sites for NX_P08913

ADRA2A Protein expression data from MOPED and PaxDb: About this image

REFSEQ proteins: NP_000672.3

ENSEMBL proteins:

ENSP00000280155

Reactome Protein details: P08913
Human Recombinant Protein Products:

	EMD Millipore Purified and/or Recombinant ADRA2A Protein
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	Browse Sino Biological Recombinant Proteins
	Browse ProSpec Recombinant Proteins
	Uscn Proteins for ADRA2A

Gene Ontology (GO): 5/6 cellular component terms (GO ID links to tree view) (see all 6): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005737	cytoplasm	IDA	19477270
GO:0005886	plasma membrane	TAS	--
GO:0005887	integral to plasma membrane	IDA	10948191
GO:0016323	basolateral plasma membrane	TAS	17655843
GO:0043235	receptor complex	IDA	10948191

ADRA2A for ontologies About GeneDecksing

ADRA2A Antibody Products:

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	Uscn Antibodies for ADRA2A
	ThermoFisher Antibodies for ADRA2A

Assay Products for ADRA2A:

	Browse Kits and Assays available from EMD Millipore
	OriGene Custom Immunoassay Development Browse OriGene Fluorogenic Cell Assay Kits
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	GenScript ADRA2A-overexpressing Cell Line for Assay
	Browse Enzo Life Sciences for kits & assays
	Uscn ELISAs and CLIAs for ADRA2A

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

ADRA2A for domains About GeneDecksing

4 InterPro domains/families:

IPR017452 GPCR_Rhodpsn_7TM

IPR002233 Adrnrgc_rcpt

IPR001946 Adren_rcpt_A2A

IPR000276 GPCR_Rhodpsn

Graphical View of Domain Structure for InterPro Entry P08913

ProtoNet protein and cluster: P08913

2 Blocks protein families:

IPB001946 Alpha-2A adrenergic receptor signature

IPB002233 Adrenergic receptor signature

UniProtKB/Swiss-Prot: ADA2A_HUMAN, P08913

Similarity: Belongs to the G-protein coupled receptor 1 family. Adrenergic receptor subfamily. ADRA2A sub-subfamily

(According to ¹UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or ²DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
About This Section

Function Summary:

UniProtKB/Swiss-Prot: ADA2A_HUMAN, P08913

Function: Alpha-2 adrenergic receptors mediate the catecholamine-induced inhibition of adenylate cyclase through the

action of G proteins. The rank order of potency for agonists of this receptor is oxymetazoline > clonidine >

epinephrine > norepinephrine > phenylephrine > dopamine > p-synephrine > p-tyramine > serotonin = p-octopamine. For

antagonists, the rank order is yohimbine > phentolamine = mianserine > chlorpromazine = spiperone = prazosin >

propanolol > alprenolol = pindolol

Genatlas biochemistry entry for ADRA2A:

adrenergic,alpha-2A-,receptor,G protein coupled receptor superfamily,inhibiting formation of cAMP opening K+

channels,inhibiting Ca2+ channels

miRNA Products:		OriGene 3'-UTR Clone: ADRA2A Browse MicroRNA Expression Plasmids
		QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat ADRA2A
		8/37 QIAGEN miScript miRNA Assays for microRNAs that regulate ADRA2A (see all 37):
		hsa-miR-3607-3p hsa-miR-1258 hsa-miR-30d hsa-miR-3142 hsa-miR-30a hsa-miR-3613-3p hsa-miR-23a hsa-miR-3622a-5p

		SwitchGear 3'UTR luciferase reporter plasmid: ADRA2A 3' UTR sequence

Inhib. RNA Products:		Browse for Gene Knock-down Tools from EMD Millipore
		OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for ADRA2A (see all 7) OriGene shRNA RFP: ADRA2A OriGene siRNA: ADRA2A
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Gene Editing
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DNA2.0 Custom Protein Engineering Service for ADRA2A

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		GenScript: all cDNA clones in your preferred vector: ADRA2A (NM_000681)
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		Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat ADRA2A

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In Situ Assay
Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ADRA2A

Gene Ontology (GO): 5/12 molecular function terms (GO ID links to tree view) (see all 12): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0004935	adrenergic receptor activity	--	--
GO:0004938	alpha2-adrenergic receptor activity	ISS	1354394
GO:0005515	protein binding	IPI	16531006
GO:0019901	protein kinase binding	IPI	15653687
GO:0031692	alpha-1B adrenergic receptor binding	ISS	--

ADRA2A for ontologies           About GeneDecksing

Animal Models:
     Mouse knock-outs for ADRA2A: Adra2a^tm1Bkk Adra2a^tm1Lel
     6 MGI mutant phenotypes (inferred from 3 alleles) (MGI details for Adra2a):

cardiovascular system	embryogenesis	homeostasis/metabolism	mortality/aging	nervous system
normal

ADRA2A for phenotypes About GeneDecksing

(Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to ¹UniProtKB, ²MINT, ³I2D, and/or ⁴STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
About This Section

Unified GeneCards pathways - 5/17 super-pathways (see all 17) About this table

See pathways by source

Super-pathway

contained gene-specific pathways

Class A/1 (Rhodopsin-like receptors)

Class A/1 (Rhodopsin-like receptors)	1.00	GPCRs, Class A Rhodopsin-like	0.41
GPCR ligand binding	0.75	Neuroactive ligand-receptor interaction	0.38
G alpha (i) signalling events	0.44

Activation of cAMP-Dependent PKA

	Activation of cAMP-Dependent PKA	1.00			Activation of PKA through GPCR	0.71
	cAMP Pathway	0.77

Signaling by GPCR

	Signaling by GPCR	1.00			Signal Transduction	0.56
	GPCR downstream signaling	0.89

Platelet activation, signaling and aggregation

Platelet activation, signaling and aggregation

1.00

Hemostasis

0.43

Adrenoceptors

Adrenoceptors

1.00

Adrenaline signalling through Alpha-2 adrenergic receptor

0.33

Pathway sources
See GeneCards unified pathways
Show all pathways

1 EMD Millipore Pathway for ADRA2A

Development Alpha-2 adrenergic receptor activation of ERK

5/6 Downloadable PowerPoint Slides of QIAGEN Pathway Central Maps for ADRA2A (see all 6)

	Activation of PKA through GPCR
	AMPK Enzyme Complex Pathway
	cAMP Pathway
	Activation of cAMP-Dependent PKA
	Signaling Involved in Cardiac Hypertrophy

1 GeneGo (Thomson Reuters) Pathway for ADRA2A

Development Alpha-2 adrenergic receptor activation of ERK

2 BioSystems Pathways for ADRA2A

	GPCRs, Class A Rhodopsin-like
	Monoamine GPCRs

5/17 Reactome Pathways for ADRA2A (see all 17)

	Metabolism
	Regulation of Insulin Secretion
	Adrenaline signalling through Alpha-2 adrenergic receptor
	G alpha (z) signalling events
	Signal Transduction

2 PharmGKB Pathways for ADRA2A

	Antiarrhythmic Pathway, Pharmacodynamics
	Sympathetic Nerve Pathway (Neuroeffector Junction)

1 Kegg Pathway (Kegg details for ADRA2A):

Neuroactive ligand-receptor interaction

ADRA2A for pathways About GeneDecksing

Interactions:

SABiosciences Gene Network Central^TM Interacting Genes and Proteins Network for ADRA2A

STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

5/155 Interacting proteins for ADRA2A (P08913³ ENSP00000280155⁴) via UniProtKB, MINT, STRING, and/or I2D (see all 155)

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
GNAO1	P09471³, ENSP00000262493⁴	I2D: score=1 STRING: ENSP00000262493
PRKCD	Q05655³, ENSP00000331602⁴	I2D: score=1 STRING: ENSP00000331602
ADRB1	P08588³, ENSP00000358301⁴	I2D: score=2 STRING: ENSP00000358301
ADRBK1	P25098³, ENSP00000312262⁴	I2D: score=2 STRING: ENSP00000312262
GNAI1	P63096³, ENSP00000343027⁴	I2D: score=1 STRING: ENSP00000343027

About this table

Gene Ontology (GO): 5/48 biological process terms (GO ID links to tree view) (see all 48): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0001819	positive regulation of cytokine production	IDA	17655843
GO:0002526	acute inflammatory response	IEA	--
GO:0006112	energy reserve metabolic process	TAS	--
GO:0006260	DNA replication	IEA	--
GO:0006928	cellular component movement	TAS	9624180

ADRA2A for ontologies About GeneDecksing

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
About This Section

ADRA2A for compounds About GeneDecksing

Browse Small Molecules at EMD Millipore

Browse drugs & compounds from Enzo Life Sciences

Compounds for ADRA2A available from Tocris Bioscience About this table

Compound	Action	CAS #
BRL 44408 maleate	Selective alpha2A antagonist	[118343-19-4]
SKF 86466 hydrochloride	Potent and selective alpha2 antagonist	[86129-54-6]
B-HT 933 dihydrochloride	Selective alpha2 agonist	[36067-72-8]
Medetomidine hydrochloride	Potent, highly selective alpha2 agonist	[106807-72-1]

8 HMDB Compounds for ADRA2A About this table

Compound	Synonyms	CAS #	PubMed Ids
Epinephrine	(-)-(R)-Epinephrine (see all 72)	51-43-4	--
Norepinephrine	(-)-(R)-Norepinephrine (see all 32)	51-41-2	--
Phenylephrine	Adrianol (see all 60)	59-42-7	--
Phenylpropanolamine	DL-Norephedrine (see all 12)	154-41-6	--
Pseudoephedrine	(+)-(1S,2S)-Pseudoephedrine (see all 25)	90-82-4	--
Tyramine	2-(4'-Hydroxyphenyl)ethylamine (see all 34)	51-67-2	--
p-Octopamine	(RS)-Octopamine (see all 17)	104-14-3	--
p-Synephrine	(+)-Synephrine (see all 3)	532-80-9	--

10/57 DrugBank Compounds for ADRA2A (see all 57) About this table

Compound	Synonyms	CAS #	Type	Actions	PubMed Ids
Apraclonidine	Apraclonidina [INN-Spanish] (see all 4)	66711-21-5	target	agonist	17572343 14575724 12630335 16935593 11481271 17139284 17824139 17016423 15748550 16921219 20399934
Methyldopa	Alpha medopa (see all 5)	555-30-6	target	--	1363322 9284427 17139284 17016423 14557373 10415926 17485976 8743022
Norepinephrine	Arterenol (see all 4)	51-41-2	target	agonist	11306720 18064417 10742288 18680204 9836297 1980236 17139284 17016423
Phentolamine	--	50-60-2	target	antagonist	12721093 1346768 12770936 16273345 10988273 17115069 7562640 6176798
Dexmedetomidine	Medetomidina [Spanish] (see all 3)	113775-47-6	target	agonist	11834617 14583739 15306201 11752127 17692748 15087625
Epinephrine	ADR Adrenaline (see all 25)	51-43-4	target	agonist	11306720 18064417 10742288 18680204 9836297 1980236
Guanfacine	Guanfacina [INN-Spanish] (see all 5)	29110-47-2	target	agonist	10942848 1356794 17173664 11164065 15928018 20331927
Mirtazapine	Mepirzepine (see all 5)	61337-67-5	target	antagonist	12523492 11607047 10793320 11939713 14628003 11931344
Yohimbine	--	146-48-5	target	antagonist	17664022 16325800 10611634 10506165 17558432 12591093
Clonidine	Chlornidinum (see all 6)	4205-90-7	target	agonist	14757140 12098614 12357167 15306201 11752127

10/35 Novoseek chemical compound relationships for ADRA2A gene (see all 35) About this table

Compound	-log (P-Val)	Hits	PubMed IDs for Articles with Shared Sentences (# sentences)
mspi	76.3	11	11886485 (1), 16917924 (1), 9112004 (1), 16806103 (1) (see all 9)
brimonidine	68.4	1	1645720 (1)
oxymetazoline	66.3	1	8538858 (1)
clonidine	63.1	1	10215641 (1)
norepinephrine	61.6	16	12514167 (2), 18193048 (2), 12959998 (1), 16756025 (1) (see all 11)
guanfacine	60.7	5	12351753 (4), 15115947 (1)
epinephrine	47.5	14	18096057 (3), 16854373 (2), 8389195 (1), 7903535 (1) (see all 9)
chloroethylclonidine	44.8	2	10438518 (1), 9495800 (1)
methylphenidate	38.6	5	17283289 (2), 19150055 (1), 16013954 (1)
dopamine	26.7	4	10334470 (1), 9208378 (1)

Search CenterWatch for drugs/clinical trials and news about ADRA2A / ADA2A

(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from EMD Millipore,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
About This Section

REFSEQ mRNAs for ADRA2A gene:

NM_000681.3

Unigene Cluster for ADRA2A:

Adrenoceptor alpha 2A

Hs.249159 [show with all ESTs]

Unigene Representative Sequence: NM_000681

1 Ensembl transcript including schematic representation, and UCSC links where relevant:

ENST00000280155(uc001kzo.3)

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		QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat ADRA2A
		8/37 QIAGEN miScript miRNA Assays for microRNAs that regulate ADRA2A (see all 37):
		hsa-miR-3607-3p hsa-miR-1258 hsa-miR-30d hsa-miR-3142 hsa-miR-30a hsa-miR-3613-3p hsa-miR-23a hsa-miR-3622a-5p

		SwitchGear 3'UTR luciferase reporter plasmid: ADRA2A 3' UTR sequence

Inhib. RNA Products:		Browse for Gene Knock-down Tools from EMD Millipore
		OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for ADRA2A (see all 7) OriGene shRNA RFP: ADRA2A OriGene siRNA: ADRA2A
		QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat ADRA2A

Clone Products:		OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for ADRA2A (see all 4) OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for ADRA2A (see all 2) OriGene custom cloning services � gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
		GenScript: all cDNA clones in your preferred vector: ADRA2A (NM_000681)
		DNA2.0 Custom Codon Optimized Gene Synthesis Service for ADRA2A
		Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat ADRA2A

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		QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat ADRA2A
		QIAGEN QuantiFast Probe-based Assays in human, mouse, rat ADRA2A

Additional cDNA sequence:

AF284095.1 BC035047.1 BC050414.1

2 DOTS entries:

DT.101972051 DT.453118

24/70 AceView cDNA sequences (see all 70):

AI656344 AI572103 AW241599 BF725007 T34699 H89355 BM723451 AW513366

AW196450 BM695296 CB045497 F09185 BC035047 AI147682 F03845 BF725008

T08946 AW075300 T16471 AI597708 Z40854 F07597 NM_000681 CB045318

GeneLoc Exon Structure

(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section

ADRA2A expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: --

About this image

ADRA2A expression in embryonic tissues and stem cells

Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine About this table

4 LifeMap In Vivo Development Anatomical Compartments/Cells

Tissue

Anatomical Compartment

Cell

Category (developmental path)

Spinal Cord

Spinal Ventral Columns

Ventral Spinal Cord Progenitor Cells

Motor Neurons

Brain

Neural Tube

Spinal Ventral Columns

Spinal Cord

Expression:

Positive

Negative

Selective marker

Experimental details:

Curated

Microarrays

In-situ hybridization

Stem Cell Differentiation: 1 LifeMap Cell

Name

Category

Sclerotome cells (Primary Cell)

Bone, Cartilage, Somite

See ADRA2A Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for ADRA2A

SOURCE GeneReport for Unigene cluster: Hs.249159

SABiosciences Expression via Pathway-Focused PCR Arrays including ADRA2A:

Neurotransmitter Receptors in human mouse rat

G Protein Coupled Receptors 384HT in human mouse rat

Cardiotoxicity in human mouse rat

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In Situ
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(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD , ⁵MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or ⁶Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
About This Section

This gene was present in the common ancestor of animals.

Orthologs for ADRA2A gene from 5/16 species (see all 16) About this table

Organism	Taxonomic classification	Gene	Description	Human Similarity	Orthology Type	Details
chicken (Gallus gallus)	Aves	ADRA2A¹	adrenergic, alpha-2A-, receptor	75.69(n) 75.61(a)		428980 XM_426537.3 XP_426537.3
lizard (Anolis carolinensis)	Reptilia	ADRA2A⁶	--	71(a)	1 ↔ 1	3(45883557-45884828)
zebrafish (Danio rerio)	Actinopterygii	adra2a¹	adrenergic, alpha-2A-, receptor	66.23(n) 69.82(a)		266750 NM_207637.2 NP_997520.2
fruit fly (Drosophila melanogaster)	Insecta	DopR2³	dopamine receptor signaling pathway dopamine receptor	44(a) (best of 2)		3 99B5 --
worm (Caenorhabditis elegans)	Secernentea	F14D12.6³	G-protein coupled receptor	42(a)		X(5644519-5646489) --

ENSEMBL Gene Tree for ADRA2A (if available)
TreeFam Gene Tree for ADRA2A (if available)

(Paralogs according to ¹HomoloGene,
²Ensembl, and ³SIMAP, Pseudogenes according to ⁴Pseudogene.org Build 68)
About This Section

Paralogs for ADRA2A gene

DRD4² HTR1A² ADRA1B² DRD2² HTR1F² HTR7² ADRA2C² HTR1D²

ADRA2B² ADRA1A² HTR1E² DRD3² HTR5A² HTR1B² ADRA1D²

9 SIMAP similar genes for ADRA2A using alignment to 1 protein entry: ADA2A_HUMAN:

ADRA2C ADRA2B DRD2 DRD3 5HT1A DRD4

HRH3 HTR1A HTR1E

ADRA2A for paralogs About GeneDecksing

(SNPs/Variants according to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section

SNP ID	Valid	Clinical significance	Chr 10 pos	Sequence	#	AA Chg	Type	More	#	Allele freq	Pop	Total sample	More
Genomic Data					Transcription Related Data				Allele Frequencies
				--	--	--		--	--
rs11195418^1,2	C,F,H,	--	106463923(+)	`GGGCTA/GTAGAC`	1	--	us2k¹		10		NS EA NA	1144
rs79481725^1,2	C,F,	--	106464756(+)	`GAGACG/TGGAGG`	1	--	us2k¹		6		NA WA CSA EA	364
rs113214539^1,2		--	106464919(+)	`CCGCAG/CACAGC`	1	--	us2k¹		1		CSA	2
rs35187985^1,2	C,F,	--	106464957(+)	`TTCTTC/GCCTAA`	1	--	us2k¹		3		NS NA	94
rs7089069^1,2	C,F,	--	106465028(+)	`GGGTTC/TCATCC`	1	--	us2k¹		9		NS NA CSA WA	794
rs36022820^1,2	C,	--	106465336(+)	`CTTTAA/GGTCTC`	1	--	us2k¹		5		NS NA	768
rs1800035^1,2	C,F,	--	106467316(+)	`CCCAAC/GGGTCT`	2	N K	mis¹		2		NS	92
rs35658213^1,2	C	--	106467764(+)	`TCGGGT/AGCTCC`	2	/S /C	mis¹		4		MN NA	121
rs77286801^1,2	C,	--	106467813(+)	`CTACTG/TCAACA`	2	C F	mis¹		0	--	--	--	--
rs34303217^1,2	C,F,	--	106468046(+)	`GGCTCT/AGCAGC`	1	--	ut3¹		3		MN WA	235

HapMap Linkage Disequilibrium report for ADRA2A (112836790 - 112840665 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV) variations for ADRA2A: --
Human Gene Mutation Database (HGMD): ADRA2A

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(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
About This Section

ADRA2A for disorders           About GeneDecksing

OMIM gene information: 104210    OMIM disorders: --

20/41 diseases for ADRA2A (see all 41):    About MalaCards

gilles de la tourette syndrome attention deficit hyperactivity disorder motion sickness tourette syndrome

orthostatic intolerance type 2 diabetes mellitus major depressive disorder learning disability

autism spectrum disorder ocular hypotension irritable bowel syndrome sleep apnea

mood disorder dyscalculia chronic fatigue syndrome alcohol abuse

anorexia nervosa neuronitis diabetes mellitus apnea

1 disease from the University of Copenhagen DISEASES database for ADRA2A:

Attention deficit hyperactivity disorder

10 Novoseek disease relationships for ADRA2A gene About this table

Disease	-log (P-Val)	Hits	PubMed IDs for Articles with Shared Sentences (# sentences)
attention-deficit hyperactivity disorder	66	16	19150055 (1), 16172611 (1), 16389583 (1), 10334470 (1) (see all 12)
tourette syndrome	47.5	4	10334470 (1), 18794646 (1), 18075481 (1), 12707939 (1)
colon carcinoma	16.5	2	9152409 (1), 8863348 (1)
tumors	0.815	2	9344667 (1)
schizophrenia	0.0789	7	17034020 (2), 19439247 (1), 15115947 (1), 18558152 (1)
cholera	0	1	1848855 (1)
mood disorders	0	2	16526032 (1), 9631415 (1)
adenocarcinoma	0	2	1677644 (1), 8863348 (1)
obesity	0	1	11886485 (1)
disability	0	2	10334470 (1), 16178932 (1)

Genetic Association Database (GAD): ADRA2A
Human Genome Epidemiology (HuGE) Navigator: ADRA2A (114 documents)

Export disorders for ADRA2A gene to outside databases

(in PubMed. Associations of this gene to articles via ¹Entrez Gene, ²UniProtKB/Swiss-Prot, ³HGNC, ⁴GAD, ⁵PharmGKB, ⁶HMDB, ⁷DrugBank, ⁸UniProtKB/TrEMBL, ⁹ Novoseek, and/or ¹⁰fRNAdb)
About This Section

PubMed articles for ADRA2A gene, integrated from 9 sources (see all 364):
(articles sorted by number of sources associating them with ADRA2A)

Utopia: connect your pdf to the dynamic
world of online information

Possible association of the alpha-2A adrenergic receptor gene (ADRA2A) with symptoms of attention-deficit/hyperactivity disorder. (PubMed id 16389583)^{1, 4, 9} Wang B....Faraone S.V. (2006)
Is the alpha-2A adrenergic receptor gene (ADRA2A) associated with attention-deficit/hyperactivity disorder? (PubMed id 12815749)^{1, 4, 9} Roman T....Hutz M.H. (2003)
Attention deficit hyperactivity disorder with reading disabilities: preliminary genetic findings on the involvement of the ADRA2A gene. (PubMed id 16178932)^{1, 4, 9} Stevenson J....Thapar A. (2005)
A C-1291G polymorphism in the alpha2A-adrenergic receptor gene (ADRA2A) promoter is associated with cortisol escape from dexamethasone and elevated glucose levels. (PubMed id 11886485)^{1, 4, 9} Rosmond R....Bjorntorp P. (2002)
Complex haplotypes derived from noncoding polymorphisms of the intronless alpha-2A-adrenergic gene diversify receptor expression. (PubMed id 16567612)^{1, 2, 9} Small K.M.... Liggett S.B. (2006)
An Asn to Lys polymorphism in the third intracellular loop of the human alpha 2A-adrenergic receptor imparts enhanced agonist-promoted Gi coupling. (PubMed id 10948191)^{1, 2, 9} Small K.M.... Liggett S.B. (2000)
A 'line item' approach to the identification of genes involved in polygenic behavioral disorders: the adrenergic alpha2A (ADRA2A) gene. (PubMed id 12627476)^{1, 4, 9} Comings D.E....MacMurray J. (2003)
A polymorphism in the alpha2a-adrenoceptor gene and endurance athlete status. (PubMed id 11039642)^{1, 4, 9} Wolfarth B....Bouchard C. (2000)
NMR structure of the second intracellular loop of the alpha 2A adrenergic receptor: evidence for a novel cytoplasmic helix. (PubMed id 11888275)^{1, 2, 9} Chung D.A....Neubig R.R. (2002)
The thiazide-sensitive Na(+)-Cl(-) cotransporter gene, C1784T, and adrenergic receptor-beta3 gene, T727C, may be gene polymorphisms susceptible to the antihypertensive effect of thiazide diuretics. (PubMed id 15824464)^{1, 4, 9} Matayoshi T....Kawano Y. (2004)

(in PubMed, OMIM, and NCBI Bookshelf)
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		AND	OR
Aliases
Disorders
Free Text

Query String		PubMed OMIM NCBI Bookshelf
	(Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
About This Section

Entrez Gene: 150	HGNC: 281	AceView: ADRA2A	Ensembl:ENSG00000150594	euGenes: HUgn150
ECgene: ADRA2A	Kegg: 150	H-InvDB: ADRA2A

(According to HUGE)
About This Section

(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section

Name	Description
PharmGKB entry for ADRA2A	Pharmacogenomics, SNPs, Pathways
SeattleSNPs	http://pga.gs.washington.edu/data/adra2a/

Intellectual Property for ADRA2A gene
(Patent information from GeneIP, Licensable technologies from WIS Yeda, Salk, Tufts, IP news from LifeMap Sciences, Inc.)

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Patent Information for ADRA2A gene:
Search GeneIP for patents involving ADRA2A

GeneCards and IP:
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adrenoceptor alpha 2A

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ADRA2A Gene

adrenoceptor alpha 2A

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