Free for academic non-profit institutions. Other users need a Commercial license

Aliases for ADRA2A Gene

Aliases for ADRA2A Gene

  • Adrenoceptor Alpha 2A 2 3
  • ADRA2R 3 4 6
  • Alpha-2 Adrenergic Receptor Subtype C10 3 4
  • Adrenergic, Alpha-2A-, Receptor 2 3
  • Alpha-2A Adrenoreceptor 3 4
  • Alpha-2AAR Subtype C10 2 3
  • Alpha-2A Adrenoceptor 3 4
  • ADRAR 3 4
  • Alpha-2-Adrenergic Receptor, Platelet Type 3
  • Alpha-2A-Adrenergic Receptor 2
  • Alpha-2A Adrenergic Receptor 3
  • Alpha-2AAR 4
  • ALPHA2AAR 3
  • ZNF32 3
  • ADRA2 3

External Ids for ADRA2A Gene

Previous HGNC Symbols for ADRA2A Gene

  • ADRA2
  • ADRA2R

Previous GeneCards Identifiers for ADRA2A Gene

  • GC10P111730
  • GC10P112070
  • GC10P112968
  • GC10P112501
  • GC10P112826
  • GC10P106465

Summaries for ADRA2A Gene

Entrez Gene Summary for ADRA2A Gene

  • Alpha-2-adrenergic receptors are members of the G protein-coupled receptor superfamily. They include 3 highly homologous subtypes: alpha2A, alpha2B, and alpha2C. These receptors have a critical role in regulating neurotransmitter release from sympathetic nerves and from adrenergic neurons in the central nervous system. Studies in mouse revealed that both the alpha2A and alpha2C subtypes were required for normal presynaptic control of transmitter release from sympathetic nerves in the heart and from central noradrenergic neurons; the alpha2A subtype inhibited transmitter release at high stimulation frequencies, whereas the alpha2C subtype modulated neurotransmission at lower levels of nerve activity. This gene encodes alpha2A subtype and it contains no introns in either its coding or untranslated sequences. [provided by RefSeq, Jul 2008]

GeneCards Summary for ADRA2A Gene

ADRA2A (Adrenoceptor Alpha 2A) is a Protein Coding gene. Diseases associated with ADRA2A include motion sickness and systolic heart failure. Among its related pathways are Signaling by GPCR and Activation of cAMP-Dependent PKA. GO annotations related to this gene include protein homodimerization activity and protein kinase binding. An important paralog of this gene is HTR1F.

UniProtKB/Swiss-Prot for ADRA2A Gene

  • Alpha-2 adrenergic receptors mediate the catecholamine-induced inhibition of adenylate cyclase through the action of G proteins. The rank order of potency for agonists of this receptor is oxymetazoline > clonidine > epinephrine > norepinephrine > phenylephrine > dopamine > p-synephrine > p-tyramine > serotonin = p-octopamine. For antagonists, the rank order is yohimbine > phentolamine = mianserine > chlorpromazine = spiperone = prazosin > propanolol > alprenolol = pindolol.

Tocris Summary for ADRA2A Gene

  • Adrenergic alpha2 receptors (alpha2-adrenoceptors) are members of the adrenergic receptor group of G-protein-coupled receptors that also includes alpha1A, alpha1B, alpha1D, beta1, beta2 and beta3. Adrenergic alpha2 receptors are divided into three subtypes: alpha2A, alpha2B and alpha2C, which are widely distributed in both the CNS and periphery. Alpha2-adrenoceptors play a role in the modulation of neurotransmission, smooth muscle contraction and thermoregulation. A fourth pharmacological subtype, alpha2D, has been identified in the rat which is thought to be a species ortholog of the human alpha2A subtype.

Gene Wiki entry for ADRA2A Gene

No data available for PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ADRA2A Gene

Genomics for ADRA2A Gene

Regulatory Elements for ADRA2A Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for ADRA2A Gene

Start:
111,077,032 bp from pter
End:
111,080,907 bp from pter
Size:
3,876 bases
Orientation:
Plus strand

Genomic View for ADRA2A Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for ADRA2A Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ADRA2A Gene

Proteins for ADRA2A Gene

  • Protein details for ADRA2A Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P08913-ADA2A_HUMAN
    Recommended name:
    Alpha-2A adrenergic receptor
    Protein Accession:
    P08913
    Secondary Accessions:
    • B0LPF6
    • Q2I8G2
    • Q2XN99
    • Q86TH8
    • Q9BZK1

    Protein attributes for ADRA2A Gene

    Size:
    450 amino acids
    Molecular mass:
    48957 Da
    Quaternary structure:
    No Data Available

    Three dimensional structures from OCA and Proteopedia for ADRA2A Gene

neXtProt entry for ADRA2A Gene

Proteomics data for ADRA2A Gene at MOPED

Post-translational modifications for ADRA2A Gene

  • Glycosylation at Asn10 and Asn14
  • Modification sites at PhosphoSitePlus

Other Protein References for ADRA2A Gene

ENSEMBL proteins:
Reactome Protein details:
REFSEQ proteins:

Antibody Products

No data available for DME Specific Peptides for ADRA2A Gene

Domains for ADRA2A Gene

Gene Families for ADRA2A Gene

HGNC:
  • ADRA :GPCR / Class A : Adrenoceptors : alpha
IUPHAR :

Suggested Antigen Peptide Sequences for ADRA2A Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

P08913

UniProtKB/Swiss-Prot:

ADA2A_HUMAN :
  • P08913
Family:
  • Belongs to the G-protein coupled receptor 1 family. Adrenergic receptor subfamily. ADRA2A sub-subfamily.
genes like me logo Genes that share domains with ADRA2A: view

Function for ADRA2A Gene

Molecular function for ADRA2A Gene

GENATLAS Biochemistry: adrenergic,alpha-2A-,receptor,G protein coupled receptor superfamily,inhibiting formation of cAMP opening K+ channels,inhibiting Ca2+ channels
UniProtKB/Swiss-Prot Function: Alpha-2 adrenergic receptors mediate the catecholamine-induced inhibition of adenylate cyclase through the action of G proteins. The rank order of potency for agonists of this receptor is oxymetazoline > clonidine > epinephrine > norepinephrine > phenylephrine > dopamine > p-synephrine > p-tyramine > serotonin = p-octopamine. For antagonists, the rank order is yohimbine > phentolamine = mianserine > chlorpromazine = spiperone = prazosin > propanolol > alprenolol = pindolol.

Gene Ontology (GO) - Molecular Function for ADRA2A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004930 G-protein coupled receptor activity --
GO:0004935 adrenergic receptor activity --
GO:0004938 alpha2-adrenergic receptor activity ISS 1354394
GO:0005515 protein binding IPI 16531006
GO:0019901 protein kinase binding IPI 15653687
genes like me logo Genes that share ontologies with ADRA2A: view
genes like me logo Genes that share phenotypes with ADRA2A: view

Animal Models for ADRA2A Gene

MGI Knock Outs for ADRA2A:

Animal Model Products

CRISPR Products

miRNA for ADRA2A Gene

miRTarBase miRNAs that target ADRA2A

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for ADRA2A

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Transcription Factor Targeting and HOMER Transcription for ADRA2A Gene

Localization for ADRA2A Gene

Subcellular locations from UniProtKB/Swiss-Prot for ADRA2A Gene

Cell membrane; Multi-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for ADRA2A Gene COMPARTMENTS Subcellular localization image for ADRA2A gene
Compartment Confidence
plasma membrane 5
endoplasmic reticulum 1
nucleus 1

Gene Ontology (GO) - Cellular Components for ADRA2A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm IDA 19477270
GO:0005886 plasma membrane TAS --
GO:0005887 integral component of plasma membrane IDA 10948191
GO:0016021 integral component of membrane --
GO:0016323 basolateral plasma membrane TAS 17655843
genes like me logo Genes that share ontologies with ADRA2A: view

Pathways for ADRA2A Gene

genes like me logo Genes that share pathways with ADRA2A: view

PCR Array Products

  • Pathway & Disease-focused RT² Profiler PCR Arrays

Gene Ontology (GO) - Biological Process for ADRA2A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001819 positive regulation of cytokine production IDA 17655843
GO:0002526 acute inflammatory response IEA --
GO:0006112 energy reserve metabolic process TAS --
GO:0006260 DNA replication IEA --
GO:0006928 movement of cell or subcellular component TAS 9624180
genes like me logo Genes that share ontologies with ADRA2A: view

Compounds for ADRA2A Gene

(5) Tocris Compounds for ADRA2A Gene

Compound Action Cas Number
Atipamezole hydrochloride Selective alpha2 antagonist [104075-48-1]
BRL 44408 maleate Selective alpha2A antagonist [681806-46-2]
Dexmedetomidine hydrochloride Potent, highly selective alpha2 agonist. Active isomer of medetomidine (Cat. No. 2023) [145108-58-3]
Imiloxan hydrochloride Highly selective alpha2B antagonist [81167-22-8]
Yohimbine hydrochloride Selective alpha2 antagonist [65-19-0]

(8) HMDB Compounds for ADRA2A Gene

Compound Synonyms Cas Number PubMed IDs
Epinephrine
  • (-)-(R)-Epinephrine
51-43-4
Norepinephrine
  • (-)-(R)-Norepinephrine
51-41-2
Phenylephrine
  • Adrianol
59-42-7
Phenylpropanolamine
  • DL-Norephedrine
154-41-6
p-Octopamine
  • (RS)-Octopamine
104-14-3

(60) Drugbank Compounds for ADRA2A Gene

Compound Synonyms Cas Number Type Actions PubMed IDs
4-Methoxyamphetamine
23239-32-9 target agonist
Amitriptyline
  • Amitriprolidine
50-48-6 target antagonist
Amoxapine
14028-44-5 target antagonist
Apomorphine
  • Apomorfin
41372-20-7 target agonist
Apraclonidine
  • Apraclonidina [INN-Spanish]
66711-21-5 target agonist

(30) IUPHAR Ligand for ADRA2A Gene

Ligand Type Action Affinity Pubmed IDs
[3H]MK-912 Antagonist Antagonist 10.1
prazosin Antagonist Inverse agonist 9.9
WB 4101 Antagonist Antagonist 9.8
dexmedetomidine Agonist Full agonist 9.3
[3H]RX821002 Antagonist Antagonist 9.2
terguride Antagonist Antagonist 8.9
spiroxatrine Agonist Full agonist 8.8
RX821002 Antagonist Antagonist 8.7
phentolamine Antagonist Antagonist 8.6
[3H]rauwolscine Antagonist Antagonist 8.4
rauwolscine Antagonist Antagonist 8.4
ARC-239 Antagonist Antagonist 8.4
clonidine Agonist Partial agonist 7.8
brimonidine Agonist Partial agonist 7.6
yohimbine Antagonist Antagonist 7.3
lisuride Agonist Partial agonist 7.2
piribedil Agonist Partial agonist 6.9
BRL 44408 Antagonist Antagonist 6.8
oxymetazoline Agonist Full agonist 6.8
cabergoline Agonist Full agonist 6.7
pergolide Agonist Full agonist 6.5
(-)-adrenaline Agonist Full agonist 6.2
bromocriptine Agonist Partial agonist 6.2
guanfacine Agonist Partial agonist 6.2
(-)-noradrenaline Agonist Full agonist 6
xylazine Agonist Partial agonist 5.9
apomorphine Activator Activation 5.1
EIPA Channel blocker None 5
HMA Allosteric regulator Negative 2.5
chlorpromazine Channel blocker None

(35) Novoseek inferred chemical compound relationships for ADRA2A Gene

Compound -log(P) Hits PubMed IDs
mspi 76.3 9
brimonidine 68.4 1
oxymetazoline 66.3 1
clonidine 63.1 1
norepinephrine 61.6 13

(3) PharmGKB related drug/compound annotations for ADRA2A Gene

Drug/compound Annotation
atenolol CA
dexmedetomidine CA
methylphenidate CA
genes like me logo Genes that share compounds with ADRA2A: view

Transcripts for ADRA2A Gene

mRNA/cDNA for ADRA2A Gene

(70) Selected AceView cDNA sequences:
(3) Additional mRNA sequences :
(1) REFSEQ mRNAs :
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for ADRA2A Gene

Adrenoceptor alpha 2A:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for ADRA2A

Primer Products

  • QuantiTect SYBR Green Assays in human,mouse,rat
  • Pre-validated RT² qPCR Primer Assay in human,mouse,rat
  • QuantiFast Probe-based Assays in human,mouse,rat

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for ADRA2A Gene

No ASD Table

Relevant External Links for ADRA2A Gene

GeneLoc Exon Structure for
ADRA2A
ECgene alternative splicing isoforms for
ADRA2A

Expression for ADRA2A Gene

mRNA expression in normal human tissues for ADRA2A Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for ADRA2A Gene

This gene is overexpressed in Cervix - Endocervix (6.3), Adipose - Subcutaneous (5.9), and Cervix - Ectocervix (5.6).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for ADRA2A Gene

SOURCE GeneReport for Unigene cluster for ADRA2A Gene Hs.249159

genes like me logo Genes that share expressions with ADRA2A: view

In Situ Assay Products

No data available for mRNA Expression by UniProt/SwissProt for ADRA2A Gene

Orthologs for ADRA2A Gene

This gene was present in the common ancestor of animals.

Orthologs for ADRA2A Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia ADRA2A 35
  • 99.28 (n)
  • 99.14 (a)
ADRA2A 36
  • 99 (a)
OneToOne
cow
(Bos Taurus)
Mammalia ADRA2A 35
  • 89.9 (n)
  • 90.65 (a)
dog
(Canis familiaris)
Mammalia ADRA2A 36
  • 92 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Adra2a 35
  • 88.03 (n)
  • 92.47 (a)
Adra2a 16
Adra2a 36
  • 92 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia ADRA2A 36
  • 87 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Adra2a 35
  • 89.03 (n)
  • 91.18 (a)
chicken
(Gallus gallus)
Aves ADRA2A 35
  • 75.57 (n)
  • 76.23 (a)
ADRA2A 36
  • 72 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia ADRA2A 36
  • 69 (a)
OneToOne
zebrafish
(Danio rerio)
Actinopterygii adra2a 35
  • 65.28 (n)
  • 67.71 (a)
adra2a 36
  • 66 (a)
OneToOne
fruit fly
(Drosophila melanogaster)
Insecta CG18208 35
  • 57.2 (n)
  • 45.37 (a)
CG18208 36
  • 24 (a)
ManyToMany
Oct-TyrR 36
  • 25 (a)
ManyToMany
DopR2 37
  • 44 (a)
CG18208 37
  • 43 (a)
worm
(Caenorhabditis elegans)
Secernentea octr-1 35
  • 47.13 (n)
  • 40.28 (a)
octr-1 36
  • 34 (a)
ManyToMany
ser-2 36
  • 30 (a)
ManyToMany
F14D12.6 37
  • 42 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 29 (a)
OneToMany
Species with no ortholog for ADRA2A:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)

Evolution for ADRA2A Gene

ENSEMBL:
Gene Tree for ADRA2A (if available)
TreeFam:
Gene Tree for ADRA2A (if available)

Paralogs for ADRA2A Gene

Paralogs for ADRA2A Gene

Selected SIMAP similar genes for ADRA2A Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with ADRA2A: view

Variants for ADRA2A Gene

Sequence variations from dbSNP and Humsavar for ADRA2A Gene

SNP ID Clin Chr 10 pos Sequence Context AA Info Type MAF
rs521674 -- 111,075,832(+) CCTTA(A/T)TGAAG upstream-variant-2KB
rs553668 Pathogenic 111,079,821(-) TTCTT(C/T)AAAAA utr-variant-3-prime
rs1800034 -- 111,078,115(+) CCGGG(C/G)CACCC reference, missense
rs1800035 - 111,078,794(+) CCCAA(C/G)GGTCT reference, missense
rs1800036 -- 111,079,146(+) ACCTC(G/T)AGAAG reference, stop-gained

Structural Variations from Database of Genomic Variants (DGV) for ADRA2A Gene

Variant ID Type Subtype PubMed ID
nsv7211 OTHER Inversion 18451855
nsv825566 CNV Gain 20364138
nsv527400 CNV Loss 19592680
nsv896004 CNV Loss 21882294
nsv896005 CNV Loss 21882294
nsv7549 CNV Insertion 18451855

Relevant External Links for ADRA2A Gene

HapMap Linkage Disequilibrium report
ADRA2A
Human Gene Mutation Database (HGMD)
ADRA2A

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ADRA2A Gene

Disorders for ADRA2A Gene

MalaCards: The human disease database

MalaCards: The human disease database. (9) Diseases for ADRA2A Gene including...

Search for ADRA2A Gene in MalaCards »

(2) University of Copenhagen DISEASES for ADRA2A Gene

(10) Novoseek inferred disease relationships for ADRA2A Gene

Disease -log(P) Hits PubMed IDs
attention-deficit hyperactivity disorder 66 12
tourette syndrome 47.5 4
colon carcinoma 16.5 2
tumors 0.815 1
schizophrenia 0.0789 5

Relevant External Links for ADRA2A

Genetic Association Database (GAD)
ADRA2A
Human Genome Epidemiology (HuGE) Navigator
ADRA2A
genes like me logo Genes that share disorders with ADRA2A: view

No data available for UniProtKB/Swiss-Prot for ADRA2A Gene

Publications for ADRA2A Gene

  1. An Asn to Lys polymorphism in the third intracellular loop of the human alpha 2A-adrenergic receptor imparts enhanced agonist-promoted Gi coupling. (PMID: 10948191) Small K.M. … Liggett S.B. (J. Biol. Chem. 2000) 3 4 23
  2. A polymorphism in the alpha2a-adrenoceptor gene and endurance athlete status. (PMID: 11039642) Wolfarth B. … Bouchard C. (Med Sci Sports Exerc 2000) 3 23 48
  3. A C-1291G polymorphism in the alpha2A-adrenergic receptor gene (ADRA2A) promoter is associated with cortisol escape from dexamethasone and elevated glucose levels. (PMID: 11886485) Rosmond R. … BjAPrntorp P. (J. Intern. Med. 2002) 3 23 48
  4. NMR structure of the second intracellular loop of the alpha 2A adrenergic receptor: evidence for a novel cytoplasmic helix. (PMID: 11888275) Chung D.A. … Neubig R.R. (Biochemistry 2002) 3 4 23
  5. A "line item" approach to the identification of genes involved in polygenic behavioral disorders: the adrenergic alpha2A (ADRA2A) gene. (PMID: 12627476) Comings D.E. … MacMurray J. (Am. J. Med. Genet. B Neuropsychiatr. Genet. 2003) 3 23 48

Products for ADRA2A Gene

Sources for ADRA2A Gene

Back to Top

Content