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Aliases for ADRA2A Gene

Aliases for ADRA2A Gene

  • Adrenoceptor Alpha 2A 2 3 5
  • Alpha-2 Adrenergic Receptor Subtype C10 3 4
  • Adrenergic, Alpha-2A-, Receptor 2 3
  • Alpha-2A Adrenoreceptor 3 4
  • Alpha-2AAR Subtype C10 2 3
  • Alpha-2A Adrenoceptor 3 4
  • ADRA2R 3 4
  • ADRAR 3 4
  • Alpha-2-Adrenergic Receptor, Platelet Type 3
  • Alpha-2A-Adrenergic Receptor 2
  • Alpha-2AAR 4
  • ALPHA2AAR 3
  • ZNF32 3
  • ADRA2 3

External Ids for ADRA2A Gene

Previous HGNC Symbols for ADRA2A Gene

  • ADRA2
  • ADRA2R

Previous GeneCards Identifiers for ADRA2A Gene

  • GC10P111730
  • GC10P112070
  • GC10P112968
  • GC10P112501
  • GC10P112826
  • GC10P106465

Summaries for ADRA2A Gene

Entrez Gene Summary for ADRA2A Gene

  • Alpha-2-adrenergic receptors are members of the G protein-coupled receptor superfamily. They include 3 highly homologous subtypes: alpha2A, alpha2B, and alpha2C. These receptors have a critical role in regulating neurotransmitter release from sympathetic nerves and from adrenergic neurons in the central nervous system. Studies in mouse revealed that both the alpha2A and alpha2C subtypes were required for normal presynaptic control of transmitter release from sympathetic nerves in the heart and from central noradrenergic neurons; the alpha2A subtype inhibited transmitter release at high stimulation frequencies, whereas the alpha2C subtype modulated neurotransmission at lower levels of nerve activity. This gene encodes alpha2A subtype and it contains no introns in either its coding or untranslated sequences. [provided by RefSeq, Jul 2008]

GeneCards Summary for ADRA2A Gene

ADRA2A (Adrenoceptor Alpha 2A) is a Protein Coding gene. Diseases associated with ADRA2A include adra2a-related altered drug metabolism and horner's syndrome. Among its related pathways are cGMP-PKG signaling pathway and Peptide ligand-binding receptors. GO annotations related to this gene include G-protein coupled receptor activity and protein heterodimerization activity. An important paralog of this gene is HTR1F.

UniProtKB/Swiss-Prot for ADRA2A Gene

  • Alpha-2 adrenergic receptors mediate the catecholamine-induced inhibition of adenylate cyclase through the action of G proteins. The rank order of potency for agonists of this receptor is oxymetazoline > clonidine > epinephrine > norepinephrine > phenylephrine > dopamine > p-synephrine > p-tyramine > serotonin = p-octopamine. For antagonists, the rank order is yohimbine > phentolamine = mianserine > chlorpromazine = spiperone = prazosin > propanolol > alprenolol = pindolol.

Tocris Summary for ADRA2A Gene

  • Adrenergic alpha2 receptors (alpha2-adrenoceptors) are members of the adrenergic receptor group of G-protein-coupled receptors that also includes alpha1A, alpha1B, alpha1D, beta1, beta2 and beta3. Adrenergic alpha2 receptors are divided into three subtypes in humans: alpha2A, alpha2B and alpha2C.

Gene Wiki entry for ADRA2A Gene

No data available for PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ADRA2A Gene

Genomics for ADRA2A Gene

Regulatory Elements for ADRA2A Gene

Enhancers for ADRA2A Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around ADRA2A on UCSC Golden Path with GeneCards custom track

Genomic Location for ADRA2A Gene

Chromosome:
10
Start:
111,077,032 bp from pter
End:
111,080,907 bp from pter
Size:
3,876 bases
Orientation:
Plus strand

Genomic View for ADRA2A Gene

Genes around ADRA2A on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ADRA2A Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ADRA2A Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ADRA2A Gene

Proteins for ADRA2A Gene

  • Protein details for ADRA2A Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P08913-ADA2A_HUMAN
    Recommended name:
    Alpha-2A adrenergic receptor
    Protein Accession:
    P08913
    Secondary Accessions:
    • B0LPF6
    • Q2I8G2
    • Q2XN99
    • Q86TH8
    • Q9BZK1

    Protein attributes for ADRA2A Gene

    Size:
    450 amino acids
    Molecular mass:
    48957 Da
    Quaternary structure:
    No Data Available

    Three dimensional structures from OCA and Proteopedia for ADRA2A Gene

neXtProt entry for ADRA2A Gene

Proteomics data for ADRA2A Gene at MOPED

Post-translational modifications for ADRA2A Gene

  • Glycosylation at Asn 10 and Asn 14
  • Modification sites at PhosphoSitePlus

Other Protein References for ADRA2A Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for ADRA2A Gene

Domains & Families for ADRA2A Gene

Gene Families for ADRA2A Gene

Suggested Antigen Peptide Sequences for ADRA2A Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

P08913

UniProtKB/Swiss-Prot:

ADA2A_HUMAN :
  • Belongs to the G-protein coupled receptor 1 family. Adrenergic receptor subfamily. ADRA2A sub-subfamily.
Family:
  • Belongs to the G-protein coupled receptor 1 family. Adrenergic receptor subfamily. ADRA2A sub-subfamily.
genes like me logo Genes that share domains with ADRA2A: view

Function for ADRA2A Gene

Molecular function for ADRA2A Gene

GENATLAS Biochemistry:
adrenergic,alpha-2A-,receptor,G protein coupled receptor superfamily,inhibiting formation of cAMP opening K+ channels,inhibiting Ca2+ channels
UniProtKB/Swiss-Prot Function:
Alpha-2 adrenergic receptors mediate the catecholamine-induced inhibition of adenylate cyclase through the action of G proteins. The rank order of potency for agonists of this receptor is oxymetazoline > clonidine > epinephrine > norepinephrine > phenylephrine > dopamine > p-synephrine > p-tyramine > serotonin = p-octopamine. For antagonists, the rank order is yohimbine > phentolamine = mianserine > chlorpromazine = spiperone = prazosin > propanolol > alprenolol = pindolol.
genes like me logo Genes that share phenotypes with ADRA2A: view

Animal Models for ADRA2A Gene

MGI Knock Outs for ADRA2A:

Animal Model Products

miRNA for ADRA2A Gene

miRTarBase miRNAs that target ADRA2A

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for ADRA2A Gene

Localization for ADRA2A Gene

Subcellular locations from UniProtKB/Swiss-Prot for ADRA2A Gene

Cell membrane; Multi-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for ADRA2A Gene COMPARTMENTS Subcellular localization image for ADRA2A gene
Compartment Confidence
plasma membrane 5
endoplasmic reticulum 1
nucleus 1

Gene Ontology (GO) - Cellular Components for ADRA2A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with ADRA2A: view

Pathways & Interactions for ADRA2A Gene

genes like me logo Genes that share pathways with ADRA2A: view

Gene Ontology (GO) - Biological Process for ADRA2A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0002526 acute inflammatory response IEA --
GO:0006928 movement of cell or subcellular component TAS 9624180
GO:0007165 signal transduction IEA,TAS 2823383
GO:0007186 G-protein coupled receptor signaling pathway IEA,ISS 19965390
GO:0007266 Rho protein signal transduction TAS 9624180
genes like me logo Genes that share ontologies with ADRA2A: view

No data available for SIGNOR curated interactions for ADRA2A Gene

Drugs & Compounds for ADRA2A Gene

(173) Drugs for ADRA2A Gene - From: DrugBank, PharmGKB, ClinicalTrials, ApexBio, DGIdb, IUPHAR, HMDB, Tocris, and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Dexmedetomidine Approved Pharma Partial agonist, Agonist, agonist, Target 491
Oxymetazoline Approved Pharma Full agonist, Agonist, agonist, Target 417
Norepinephrine Approved Pharma stimulator, Target, agonist 654
Brimonidine Approved Pharma Full agonist, Agonist, agonist, Target 0
Guanfacine Approved, Investigational Pharma Partial agonist, Agonist, agonist, Target 55

(20) Additional Compounds for ADRA2A Gene - From: Novoseek, HMDB, IUPHAR, and Tocris

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
EIPA
Positive, Allosteric regulator
HMA
Negative, Allosteric regulator
p-Octopamine
  • (RS)-Octopamine
  • 1-(p-Hydroxyphenyl)-2-aminoethanol
  • 2-Amino-1-(4-hydroxyphenyl)ethanol
  • 4-Hydroxyphenethanolamine
  • 4-[2-Amino-1-hydroxyethyl]phenol
104-14-3
p-Synephrine
  • (+)-p-Synephrine
  • (+)-Synephrine
  • (+)-[(methylamino)methyl]-Benzenemethano
  • Analeptin
  • Oxedrine
94-07-5
Clonidine hydrochloride
4205-91-8

(5) Tocris Compounds for ADRA2A Gene

Compound Action Cas Number
Clonidine hydrochloride alpha2 agonist. Also I1 ligand 4205-91-8
Guanabenz acetate alpha2 agonist. Also I2 selective ligand 23256-50-0
Guanfacine hydrochloride alpha2A agonist 29110-48-3
Rilmenidine hemifumarate alpha2 agonist. Also I1 ligand 207572-68-7
UK 14,304 alpha2 agonist 59803-98-4

(59) ApexBio Compounds for ADRA2A Gene

Compound Action Cas Number
Acebutolol HCl 34381-68-5
Adrenalone HCl 62-13-5
Alfuzosin HCl α1 adrenoceptor antagonist,functionally uro-selective 81403-68-1
Bambuterol 81732-65-2
Betaxolol βadrenergic receptor blocker 659-18-7
Betaxolol HCl 63659-19-8
Bisoprolol fumarate 104344-23-2
Brimonidine Tartrate 70359-46-5
Carvedilol 72956-09-3
Cisatracurium Besylate Neuromuscular-blocking drug 96946-42-8
Clonidine HCl 4205-91-8
Detomidine HCl 90038-01-0
Dexmedetomidine 113775-47-6
Dexmedetomidine HCl 145108-58-3
DL-Adrenaline 329-65-7
Doxazosin Mesylate α1-adrenergic receptor antagonist 77883-43-3
Droxidopa 23651-95-8
Epinephrine Bitartrate 51-42-3
Epinephrine HCl 55-31-2
Formoterol Hemifumarate 43229-80-7
Guanabenz Acetate 23256-50-0
Indacaterol Maleate 753498-25-8
Isoprenaline HCl 51-30-9
Ivabradine HCl 148849-67-6
Labetalol HCl 32780-64-6
L-Adrenaline 51-43-4
Maprotiline HCl 10347-81-6
Medetomidine HCl 86347-15-1
Methyldopa 555-30-6
Metoprolol Tartrate β1-adrenergic blocking agent 392-17-7
Mirabegron (YM178) 223673-61-8
Moxonidine hydrochloride α2AR/I1R agonist 75536-04-8
Naftopidil α1-adrenergic receptor antagonist 57149-07-2
Naftopidil DiHCl 57149-08-3
Naphazoline HCl 550-99-2
Nebivolol 152520-56-4
Nedaplatin 95734-82-0
Noradrenaline bitartrate monohydrate 108341-18-0
Oxymetazoline HCl Alpha-1/alpha-2 agonist 2315-02-8
Phenoxybenzamine HCl 63-92-3
Phentolamine Mesylate Alpha 1/2-blocking agent 65-28-1
Phenylephrine HCl 61-76-7
Prazosin HCl α1 and α2B-adrenoceptor antagonist 19237-84-4
Propranolol HCl 318-98-9
Ritodrine HCl β-2 adrenergic receptor agonist 23239-51-2
Salbutamol Sulfate β-2 adrenergic receptor agonist 51022-70-9
Salmeterol xinafoate β2-adrenergic receptor agonist 94749-08-3
Scopine 498-45-3
Silodosin α1-adrenoceptor antagonist 160970-54-7
Synephrine 1994-07-5
Synephrine HCl 5985-28-4
Terazosin HCl 70024-40-7
Terbutaline Sulfate 23031-32-5
Tetrahydrozoline HCl 522-48-5
Timolol Maleate 26921-17-5
Tizanidine HCl 64461-82-1
Tolazoline HCl 59-97-2
Xylazine HCl α2 Adrenoceptor agonist 23076-35-9
Xylometazoline HCl 1218-35-5
genes like me logo Genes that share compounds with ADRA2A: view

Transcripts for ADRA2A Gene

mRNA/cDNA for ADRA2A Gene

(1) REFSEQ mRNAs :
(3) Additional mRNA sequences :
(70) Selected AceView cDNA sequences:
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for ADRA2A Gene

Adrenoceptor alpha 2A:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for ADRA2A Gene

No ASD Table

Relevant External Links for ADRA2A Gene

GeneLoc Exon Structure for
ADRA2A
ECgene alternative splicing isoforms for
ADRA2A

Expression for ADRA2A Gene

mRNA expression in normal human tissues for ADRA2A Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for ADRA2A Gene

This gene is overexpressed in Cervix - Endocervix (x6.3), Adipose - Subcutaneous (x5.9), and Cervix - Ectocervix (x5.6).

Protein differential expression in normal tissues from HIPED for ADRA2A Gene

This gene is overexpressed in Fetal Brain (39.4), Peripheral blood mononuclear cells (16.4), and Adipocyte (7.8).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for ADRA2A Gene



SOURCE GeneReport for Unigene cluster for ADRA2A Gene Hs.249159

genes like me logo Genes that share expression patterns with ADRA2A: view

Protein tissue co-expression partners for ADRA2A Gene

Primer Products

In Situ Assay Products

No data available for mRNA Expression by UniProt/SwissProt for ADRA2A Gene

Orthologs for ADRA2A Gene

This gene was present in the common ancestor of animals.

Orthologs for ADRA2A Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia ADRA2A 35
  • 89.9 (n)
  • 90.65 (a)
mouse
(Mus musculus)
Mammalia Adra2a 35
  • 88.03 (n)
  • 92.47 (a)
Adra2a 16
Adra2a 36
  • 92 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia ADRA2A 35
  • 99.28 (n)
  • 99.14 (a)
ADRA2A 36
  • 99 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Adra2a 35
  • 89.03 (n)
  • 91.18 (a)
dog
(Canis familiaris)
Mammalia ADRA2A 36
  • 92 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia ADRA2A 36
  • 87 (a)
OneToOne
chicken
(Gallus gallus)
Aves ADRA2A 35
  • 75.57 (n)
  • 76.23 (a)
ADRA2A 36
  • 72 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia ADRA2A 36
  • 69 (a)
OneToOne
zebrafish
(Danio rerio)
Actinopterygii adra2a 35
  • 65.28 (n)
  • 67.71 (a)
adra2a 36
  • 66 (a)
OneToOne
fruit fly
(Drosophila melanogaster)
Insecta CG18208 37
  • 43 (a)
DopR2 37
  • 44 (a)
CG18208 35
  • 57.2 (n)
  • 45.37 (a)
CG18208 36
  • 24 (a)
ManyToMany
Oct-TyrR 36
  • 25 (a)
ManyToMany
worm
(Caenorhabditis elegans)
Secernentea F14D12.6 37
  • 42 (a)
octr-1 35
  • 47.13 (n)
  • 40.28 (a)
octr-1 36
  • 34 (a)
ManyToMany
ser-2 36
  • 30 (a)
ManyToMany
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 29 (a)
OneToMany
Species with no ortholog for ADRA2A:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)

Evolution for ADRA2A Gene

ENSEMBL:
Gene Tree for ADRA2A (if available)
TreeFam:
Gene Tree for ADRA2A (if available)

Paralogs for ADRA2A Gene

(3) SIMAP similar genes for ADRA2A Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with ADRA2A: view

Variants for ADRA2A Gene

Sequence variations from dbSNP and Humsavar for ADRA2A Gene

SNP ID Clin Chr 10 pos Sequence Context AA Info Type
rs1800035 - 111,078,794(+) CCCAA(C/G)GGTCT reference, missense
rs35658213 - 111,079,242(+) TCGGG(A/T)GCTCC reference, missense
rs1800034 -- 111,078,115(+) CCGGG(C/G)CACCC reference, missense
rs1800036 -- 111,079,146(+) ACCTC(G/T)AGAAG reference, stop-gained
rs1800038 -- 111,079,134(+) GCGGG(A/C)GGCAG reference, synonymous-codon

Structural Variations from Database of Genomic Variants (DGV) for ADRA2A Gene

Variant ID Type Subtype PubMed ID
nsv7211 OTHER Inversion 18451855
nsv825566 CNV Gain 20364138
nsv527400 CNV Loss 19592680
nsv896004 CNV Loss 21882294
nsv896005 CNV Loss 21882294
nsv7549 CNV Insertion 18451855

Variation tolerance for ADRA2A Gene

Residual Variation Intolerance Score: 62.8% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 3.09; 50.85% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for ADRA2A Gene

HapMap Linkage Disequilibrium report
ADRA2A
Human Gene Mutation Database (HGMD)
ADRA2A

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ADRA2A Gene

Disorders for ADRA2A Gene

MalaCards: The human disease database

(13) MalaCards diseases for ADRA2A Gene - From: GeneTests, DISEASES, Novoseek, and GeneCards

Disorder Aliases PubMed IDs
adra2a-related altered drug metabolism
horner's syndrome
  • bernard horner syndrome
congenital horner syndrome
  • congenital claude-bernard-horner syndrome
pulmonary edema
gilles de la tourette syndrome
  • tourette syndrome
- elite association - COSMIC cancer census association via MalaCards

Relevant External Links for ADRA2A

Genetic Association Database (GAD)
ADRA2A
Human Genome Epidemiology (HuGE) Navigator
ADRA2A
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
ADRA2A
genes like me logo Genes that share disorders with ADRA2A: view

No data available for UniProtKB/Swiss-Prot and Genatlas for ADRA2A Gene

Publications for ADRA2A Gene

  1. The alpha 2A-adrenergic receptor gene polymorphism modifies antidepressant responses to milnacipran. (PMID: 18794646) Wakeno M. … Kinoshita T. (J Clin Psychopharmacol 2008) 3 23 48 67
  2. Dynamic strength training improves insulin sensitivity and functional balance between adrenergic alpha 2A and beta pathways in subcutaneous adipose tissue of obese subjects. (PMID: 16273345) Polak J. … Berlan M. (Diabetologia 2005) 23 25 26
  3. Molecular mechanism for agonist-promoted alpha(2A)-adrenoceptor activation by norepinephrine and epinephrine. (PMID: 11306720) NyrAPnen T. … Johnson M.S. (Mol. Pharmacol. 2001) 23 25 26
  4. A preliminary candidate genotype-intermediate phenotype study of satiation and gastric motor function in obesity. (PMID: 19876010) Papathanasopoulos A. … Zinsmeister A.R. (Obesity (Silver Spring) 2010) 3 23
  5. Effect of alpha2A-adrenoceptor C-1291G genotype and maltreatment on hyperactivity and inattention in adolescents. (PMID: 19922756) Kiive E. … Harro J. (Prog. Neuropsychopharmacol. Biol. Psychiatry 2010) 3 23

Products for ADRA2A Gene

Sources for ADRA2A Gene

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