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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

ADRA2A Gene

protein-coding   GIFtS: 68
GCID: GC10P112826

Adrenoceptor Alpha 2A

(Previous names: adrenergic, alpha-2A-, receptor)
(Previous symbols: ADRA2, ADRA2R)
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(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
Adrenoceptor Alpha 2A1 2     ADRAR2 3
ADRA2R1 2 3 5      Alpha-2A-Adrenergic Receptor1
ADRA21 2     ALPHA2AAR2
Adrenergic, Alpha-2A-, Receptor1 2     ZNF322
Alpha-2AAR Subtype C101 2     Alpha-2-Adrenergic Receptor, Platelet Type2
Alpha-2 Adrenergic Receptor Subtype C102 3     Alpha-2A Adrenergic Receptor2
Alpha-2A Adrenoceptor2 3     Alpha-2AAR3
Alpha-2A Adrenoreceptor2 3     

External Ids:    HGNC: 2811   Entrez Gene: 1502   Ensembl: ENSG000001505947   OMIM: 1042105   UniProtKB: P089133   

Export aliases for ADRA2A gene to outside databases

Previous GC identifers: GC10P111730 GC10P112070 GC10P112968 GC10P112501 GC10P106465


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for ADRA2A Gene:
Alpha-2-adrenergic receptors are members of the G protein-coupled receptor superfamily. They include 3 highly
homologous subtypes: alpha2A, alpha2B, and alpha2C. These receptors have a critical role in regulating
neurotransmitter release from sympathetic nerves and from adrenergic neurons in the central nervous system.
Studies in mouse revealed that both the alpha2A and alpha2C subtypes were required for normal presynaptic control
of transmitter release from sympathetic nerves in the heart and from central noradrenergic neurons; the alpha2A
subtype inhibited transmitter release at high stimulation frequencies, whereas the alpha2C subtype modulated
neurotransmission at lower levels of nerve activity. This gene encodes alpha2A subtype and it contains no introns
in either its coding or untranslated sequences. (provided by RefSeq, Jul 2008)

GeneCards Summary for ADRA2A Gene: 
ADRA2A (adrenoceptor alpha 2A) is a protein-coding gene. Diseases associated with ADRA2A include motion sickness, and dyscalculia, and among its related super-pathways are Class A/1 (Rhodopsin-like receptors) and Adrenaline signalling through Alpha-2 adrenergic receptor. GO annotations related to this gene include protein kinase binding and protein homodimerization activity. An important paralog of this gene is HTR2A.

UniProtKB/Swiss-Prot: ADA2A_HUMAN, P08913
Function: Alpha-2 adrenergic receptors mediate the catecholamine-induced inhibition of adenylate cyclase through
the action of G proteins. The rank order of potency for agonists of this receptor is oxymetazoline > clonidine >
epinephrine > norepinephrine > phenylephrine > dopamine > p-synephrine > p-tyramine > serotonin = p-octopamine.
For antagonists, the rank order is yohimbine > phentolamine = mianserine > chlorpromazine = spiperone = prazosin
> propanolol > alprenolol = pindolol

summary for ADRA2A Gene:
Adrenergic alpha2 receptors (alpha2-adrenoceptors) are members of the adrenergic receptor group of
G-protein-coupled receptors that also includes alpha1A, alpha1B, alpha1D, beta1, beta2 and beta3. Adrenergic
alpha2 receptors are divided into three subtypes: alpha2A, alpha2B and alpha2C, which are widely distributed
in both the CNS and periphery. Alpha2-adrenoceptors play a role in the modulation of neurotransmission,
smooth muscle contraction and thermoregulation. A fourth pharmacological subtype, alpha2D, has been
identified in the rat which is thought to be a species ortholog of the human alpha2A subtype.

Gene Wiki entry for ADRA2A (Alpha-2A adrenergic receptor) Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000010.10  NC_018921.2  NT_030059.13  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the ADRA2A gene promoter:
         Max1   Bach1   E47   Arnt   AREB6   E2F   E2F-1   c-Myc   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmids (see all 2): ADRA2A promoter sequence
   Search SABiosciences Chromatin IP Primers for ADRA2A

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat ADRA2A


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 10q25.2   Ensembl cytogenetic band:  10q25.2   HGNC cytogenetic band: 10q25.2

ADRA2A Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
ADRA2A gene location

GeneLoc information about chromosome 10         GeneLoc Exon Structure

GeneLoc location for GC10P112826:  view genomic region     (about GC identifiers)

Start:
112,836,790 bp from pter      End:
112,840,665 bp from pter
Size:
3,876 bases      Orientation:
plus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: ADA2A_HUMAN, P08913 (See protein sequence)
Recommended Name: Alpha-2A adrenergic receptor  
Size: 450 amino acids; 48957 Da
Subcellular location: Cell membrane; Multi-pass membrane protein
4 PDB 3D structures from and Proteopedia for ADRA2A:
1HLL (3D)        1HO9 (3D)        1HOD (3D)        1HOF (3D)    
Secondary accessions: B0LPF6 Q2I8G2 Q2XN99 Q86TH8 Q9BZK1

Explore the universe of human proteins at neXtProt for ADRA2A: NX_P08913

Explore proteomics data for ADRA2A at MOPED 

Post-translational modifications:

  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_P08913

  • ADRA2A Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    ADRA2A Protein Expression
    REFSEQ proteins: NP_000672.3  
    ENSEMBL proteins: 
     ENSP00000280155  
    Reactome Protein details: P08913
    Human Recombinant Protein Products for ADRA2A: 
    EMD Millipore Purified and/or Recombinant ADRA2A Protein
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    Browse recombinant and purified proteins available from Enzo Life Sciences
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    OriGene Protein Over-expression Lysate for ADRA2A
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    GenScript Custom Purified and Recombinant Proteins Services for ADRA2A
    Novus Biologicals ADRA2A Protein
    Novus Biologicals ADRA2A Lysate
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates 
    Browse ProSpec Recombinant Proteins
    Browse Proteins at Cloud-Clone Corp. 

    Gene Ontology (GO): 5/7 cellular component terms (GO ID links to tree view) (see all 7):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005737cytoplasm IDA19477270
    GO:0005886plasma membrane TAS--
    GO:0005887integral to plasma membrane IDA10948191
    GO:0016021integral to membrane ----
    GO:0016323basolateral plasma membrane TAS17655843

    ADRA2A for ontologies           About GeneDecksing



    ADRA2A Antibody Products: 
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    Novus Biologicals ADRA2A Antibodies
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    ThermoFisher Antibodies for ADRA2A
    LSBio Antibodies in human, mouse, rat for ADRA2A 

    Assay Products for ADRA2A: 
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    GenScript ADRA2A-overexpressing Cell Line for Assay
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    Browse ELISAs at Cloud-Clone Corp. 
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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    HGNC Gene Families: 
    ADRA: GPCR / Class A : Adrenoceptors : alpha

    IUPHAR Guide to PHARMACOLOGY protein family classification: α2A-adrenoceptor 
    Adrenoceptors

    4 InterPro protein domains:
     IPR017452 GPCR_Rhodpsn_7TM
     IPR002233 Adrnrgc_rcpt
     IPR001946 Adren_rcpt_A2A
     IPR000276 GPCR_Rhodpsn

    Graphical View of Domain Structure for InterPro Entry P08913

    ProtoNet protein and cluster: P08913

    2 Blocks protein domains:
    IPB001946 Alpha-2A adrenergic receptor signature
    IPB002233 Adrenergic receptor signature


    UniProtKB/Swiss-Prot: ADA2A_HUMAN, P08913
    Similarity: Belongs to the G-protein coupled receptor 1 family. Adrenergic receptor subfamily. ADRA2A
    sub-subfamily


    ADRA2A for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: ADA2A_HUMAN, P08913
    Function: Alpha-2 adrenergic receptors mediate the catecholamine-induced inhibition of adenylate cyclase through
    the action of G proteins. The rank order of potency for agonists of this receptor is oxymetazoline > clonidine >
    epinephrine > norepinephrine > phenylephrine > dopamine > p-synephrine > p-tyramine > serotonin = p-octopamine.
    For antagonists, the rank order is yohimbine > phentolamine = mianserine > chlorpromazine = spiperone = prazosin
    > propanolol > alprenolol = pindolol

         Genatlas biochemistry entry for ADRA2A:
    adrenergic,alpha-2A-,receptor,G protein coupled receptor superfamily,inhibiting formation of cAMP opening K+
    channels,inhibiting Ca2+ channels

         Gene Ontology (GO): 5/13 molecular function terms (GO ID links to tree view) (see all 13):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0004930G-protein coupled receptor activity ----
    GO:0004935adrenergic receptor activity ----
    GO:0004938alpha2-adrenergic receptor activity ISS1354394
    GO:0005515protein binding IPI16531006
    GO:0019901protein kinase binding IPI15653687
         
    ADRA2A for ontologies           About GeneDecksing


    Phenotypes:
         7 MGI mutant phenotypes (inferred from 3 alleles(MGI details for Adra2a):
     behavior/neurological  cardiovascular system  embryogenesis  homeostasis/metabolism  mortality/aging 
     nervous system  normal 

    ADRA2A for phenotypes           About GeneDecksing

    Animal Models:
         MGI mouse knock-outs for ADRA2A: Adra2atm1Bkk Adra2atm1Lel

       inGenious Targeting Laboratory - Custom generated mouse model solutions for ADRA2A 
       inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for ADRA2A

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for ADRA2A 
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for ADRA2A 

    miRNA
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    8/37 QIAGEN miScript miRNA Assays for microRNAs that regulate ADRA2A (see all 37):
    hsa-miR-3607-3p hsa-miR-1258 hsa-miR-30d hsa-miR-3142 hsa-miR-30a hsa-miR-3613-3p hsa-miR-23a hsa-miR-3622a-5p
    SwitchGear 3'UTR luciferase reporter plasmidADRA2A 3' UTR sequence
    Inhib. RNA
    Products:
        
    Browse for Gene Knock-down Tools from EMD Millipore
    OriGene RNAi products in human, mouse, rat for ADRA2A
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat ADRA2A

    Gene Editing
    Products:
    DNA2.0 Custom Protein Engineering Service for ADRA2A
    Sirion Biotech Customized adenovirus for overexpression of ADRA2A

    Clone
    Products:
         
    EMD Millipore Clones for the Expression of ADRA2A
    OriGene clones in human, mouse for ADRA2A (see all 9)
    OriGene ORF clones in mouse, rat for ADRA2A
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: ADRA2A (NM_000681)
    Browse Sino Biological Human cDNA Clones
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for ADRA2A
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat ADRA2A
    Sirion Biotech Customized lentivirus for stable overexpression of ADRA2A 
                         Customized lentivirus expression plasmids for stable overexpression of ADRA2A 

    Cell Line
    Products:
         
    GenScript ADRA2A-overexpressing Cell Line for Assay
    Search LifeMap BioReagents cell lines for ADRA2A
    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ADRA2A


    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section

    SuperPaths for ADRA2A About   (see all 16)                                                                                              See pathways by source

    SuperPathContained pathways About
    1Class A/1 (Rhodopsin-like receptors)
    Class A/1 (Rhodopsin-like receptors)0.71
    GPCRs, Class A Rhodopsin-like0.41
    GPCR ligand binding0.71
    Neuroactive ligand-receptor interaction0.37
    G alpha (i) signalling events0.46
    2Adrenoceptors
    Adrenoceptors0.33
    Sympathetic Nerve Pathway (Neuroeffector Junction)0.33
    Adrenaline signalling through Alpha-2 adrenergic receptor0.33
    3Monoamine GPCRs
    Monoamine GPCRs0.79
    Amine ligand-binding receptors0.79
    4Signaling by GPCR
    Signaling by GPCR0.90
    Signal Transduction0.55
    GPCR downstream signaling0.90
    5Activation of cAMP-Dependent PKA
    Activation of cAMP-Dependent PKA0.77
    Activation of PKA through GPCR0.71
    cAMP Pathway0.77

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    1 EMD Millipore Pathway for ADRA2A
        Development Alpha-2 adrenergic receptor activation of ERK

    5/6 Downloadable PowerPoint Slides of QIAGEN Pathway Central Maps for ADRA2A (see all 6)
        Activation of PKA through GPCR
    AMPK Enzyme Complex Pathway
    cAMP Pathway
    Activation of cAMP-Dependent PKA
    Signaling Involved in Cardiac Hypertrophy

    1 GeneGo (Thomson Reuters) Pathway for ADRA2A
        Development Alpha-2 adrenergic receptor activation of ERK

    2 BioSystems Pathways for ADRA2A
        GPCRs, Class A Rhodopsin-like
    Monoamine GPCRs

    5/17        Reactome Pathways for ADRA2A (see all 17)
        Metabolism
    Regulation of Insulin Secretion
    Adrenaline signalling through Alpha-2 adrenergic receptor
    G alpha (z) signalling events
    Signal Transduction

    2 PharmGKB Pathways for ADRA2A
        Antiarrhythmic Pathway, Pharmacodynamics
    Sympathetic Nerve Pathway (Neuroeffector Junction)

    1         Kegg Pathway  (Kegg details for ADRA2A):
        Neuroactive ligand-receptor interaction


    ADRA2A for pathways           About GeneDecksing

    Interactions:

        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for ADRA2A

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    5/156 Interacting proteins for ADRA2A (P089133 ENSP000002801554) via UniProtKB, MINT, STRING, and/or I2D (see all 156)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    GNAO1P094713, ENSP000002624934I2D: score=1 STRING: ENSP00000262493
    PRKCDQ056553, ENSP000003316024I2D: score=1 STRING: ENSP00000331602
    ADRB1P085883, ENSP000003583014I2D: score=2 STRING: ENSP00000358301
    ADRBK1P250983, ENSP000003122624I2D: score=2 STRING: ENSP00000312262
    GNAI1P630963, ENSP000003430274I2D: score=1 STRING: ENSP00000343027
    About this table

    Gene Ontology (GO): 5/47 biological process terms (GO ID links to tree view) (see all 47):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0001819positive regulation of cytokine production IDA17655843
    GO:0002526acute inflammatory response IEA--
    GO:0006112energy reserve metabolic process TAS--
    GO:0006260DNA replication IEA--
    GO:0006928cellular component movement TAS9624180

    ADRA2A for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section

    ADRA2A for compounds           About GeneDecksing

    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Compounds for ADRA2A available from Tocris Bioscience    About this table
    CompoundAction CAS #
    JP 1302 dihydrochloridePotent and selective alpha2C antagonist[80259-18-3]
    BRL 44408 maleateSelective alpha2A antagonist[118343-19-4]
    Atipamezole hydrochlorideSelective alpha2 antagonist[104075-48-1]
    Medetomidine hydrochloride Potent, highly selective alpha2 agonist [106807-72-1]
    Dexmedetomidine hydrochloride Potent, highly selective alpha2 agonist. Active isomer of medetomidine (Cat. No. 2023) [145108-58-3]

    8 HMDB Compounds for ADRA2A    About this table
    CompoundSynonyms CAS #PubMed Ids
    Epinephrine(-)-(R)-Epinephrine (see all 72)51-43-4--
    Norepinephrine(-)-(R)-Norepinephrine (see all 32)51-41-2--
    PhenylephrineAdrianol (see all 60)59-42-7--
    PhenylpropanolamineDL-Norephedrine (see all 12)154-41-6--
    Pseudoephedrine(+)-(1S,2S)-Pseudoephedrine (see all 25)90-82-4--
    Tyramine2-(4'-Hydroxyphenyl)ethylamine (see all 34)51-67-2--
    p-Octopamine(RS)-Octopamine (see all 17)104-14-3--
    p-Synephrine(+)-Synephrine (see all 3)532-80-9--

    10/60 DrugBank Compounds for ADRA2A (see all 60)    About this table
    CompoundSynonyms CAS #TypeActionsPubMed Ids
    ApraclonidineApraclonidina [INN-Spanish] (see all 4)66711-21-5targetagonist17572343 14575724 12630335 16935593 11481271 17139284 17824139 17016423 15748550 16921219 20399934
    MethyldopaAlpha medopa (see all 5)555-30-6target--1363322 9284427 17139284 17016423 14557373 10415926 17485976 8743022
    NorepinephrineArterenol (see all 4)51-41-2targetagonist11306720 18064417 10742288 18680204 9836297 1980236 17139284 17016423
    Phentolamine-- 50-60-2targetantagonist12721093 1346768 12770936 16273345 10988273 17115069 7562640 6176798
    DexmedetomidineMedetomidina [Spanish] (see all 3)113775-47-6targetagonist11834617 14583739 15306201 11752127 17692748 15087625
    EpinephrineADR Adrenaline (see all 25)51-43-4targetagonist11306720 18064417 10742288 18680204 9836297 1980236
    GuanfacineGuanfacina [INN-Spanish] (see all 5)29110-47-2targetagonist10942848 1356794 17173664 11164065 15928018 20331927
    MirtazapineMepirzepine (see all 5)61337-67-5targetantagonist12523492 11607047 10793320 11939713 14628003 11931344
    Yohimbine-- 146-48-5targetantagonist17664022 16325800 10611634 10506165 17558432 12591093
    ClonidineChlornidinum (see all 6)4205-90-7targetagonist14757140 12098614 12357167 15306201 11752127

    10/30 IUPHAR Ligands for ADRA2A2A-adrenoceptor) (see all 30)    About this table 
    LigandTypeActionAffinityPubmed IDs
    lisuride
    AntagonistAntagonist10.312388666
    dexmedetomidine
    AgonistPartial agonist7.6 - 9.69605427 9760042 9824686
    terguride
    AntagonistAntagonist9.512388666
    [3H]RX821002
    AntagonistAntagonist8.8 - 9.57908642 8819505
    [3H]rauwolscine
    AntagonistAntagonist9.58819505 1353247
    clonidine
    AgonistPartial agonist7.2 - 9.29605427 9760042 9824686
    yohimbine
    AntagonistAntagonist8.4 - 9.27908642 7996470 1353247
    RX821002
    AntagonistAntagonist9.27996470
    [3H]MK-912
    AntagonistAntagonist8.97996470
    WB 4101
    AntagonistAntagonist7.6 - 8.97908642 7996470 1353247

    10/35 Novoseek inferred chemical compound relationships for ADRA2A gene (see all 35)    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    mspi 76.3 11 11886485 (1), 16917924 (1), 9112004 (1), 16806103 (1) (see all 9)
    brimonidine 68.4 1 1645720 (1)
    oxymetazoline 66.3 1 8538858 (1)
    clonidine 63.1 1 10215641 (1)
    norepinephrine 61.6 16 12514167 (2), 18193048 (2), 12959998 (1), 16756025 (1) (see all 11)
    guanfacine 60.7 5 12351753 (4), 15115947 (1)
    epinephrine 47.5 14 18096057 (3), 16854373 (2), 8389195 (1), 7903535 (1) (see all 9)
    chloroethylclonidine 44.8 2 10438518 (1), 9495800 (1)
    methylphenidate 38.6 5 17283289 (2), 19150055 (1), 16013954 (1)
    dopamine 26.7 4 10334470 (1), 9208378 (1)

    Search CenterWatch for drugs/clinical trials and news about ADRA2A / ADA2A

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for ADRA2A gene: 
    NM_000681.3  

    Unigene Cluster for ADRA2A:

    Adrenoceptor alpha 2A
    Hs.249159  [show with all ESTs]
    Unigene Representative Sequence: NM_000681
    1 Ensembl transcript including schematic representation, and UCSC links where relevant:
    ENST00000280155(uc001kzo.3)

    miRNA
    Products:
         
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    Additional mRNA sequence: 

    AF284095.1 BC035047.1 BC050414.1 

    2 DOTS entries:

    DT.101972051  DT.453118 

    24/70 AceView cDNA sequences (see all 70):

    T08946 AI597708 BF725007 BM723451 AW241599 T16471 AI572103 AI656344 
    CB045497 AI147682 BC035047 AW075300 H89355 BF725008 F09185 T34699 
    Z40854 BM695296 AW196450 AW513366 F03845 BQ923710 BM666464 AW955575 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    ADRA2A expression in normal human tissues (normalized intensities)      ADRA2A embryonic expression: see
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: --
    ADRA2A Expression
    About this image


    ADRA2A expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database 
     5/9 selected tissues (see all 9) fully expand
     
     Brain (Nervous System)    fully expand to see all 18 entries
             Thalamus
             Septum   
     
     Neural Tube (Nervous System)    fully expand to see all 3 entries
             Spinal Ventral Columns
     
     Spinal Cord (Nervous System)    fully expand to see all 2 entries
             Dorsal Horn   
     
     Neural Crest (Gastrulation Derivatives)
             skeleton/cranium/chondrocranium   
     
     Bone (Gastrulation Derivatives)
             skeleton/cranium/chondrocranium   

    See ADRA2A Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for ADRA2A

    SOURCE GeneReport for Unigene cluster: Hs.249159
        SABiosciences Expression via Pathway-Focused PCR Arrays including ADRA2A: 
              Neurotransmitter Receptors in human mouse rat
              G Protein Coupled Receptors 384HT in human mouse rat
              Cardiotoxicity in human mouse rat

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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of animals.

    Orthologs for ADRA2A gene from 6/11 species (see all 11)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Adra2a1 , 5 adrenergic receptor, alpha 2a1, 5 88.03(n)1
    92.47(a)1
      19 (49.04 cM)5
    115511  NM_007417.41  NP_031443.41 
     540451825 
    chicken
    (Gallus gallus)
    Aves ADRA2A1 adrenergic, alpha-2A-, receptor 75.69(n)
    75.61(a)
      428980  XM_426537.3  XP_426537.3 
    lizard
    (Anolis carolinensis)
    Reptilia ADRA2A6
    Uncharacterized protein
    68(a)
    1 ↔ 1
    3(45883473-45884828)
    zebrafish
    (Danio rerio)
    Actinopterygii adra2a1 adrenergic, alpha-2A-, receptor 66.23(n)
    69.82(a)
      266750  NM_207637.2  NP_997520.2 
    fruit fly
    (Drosophila melanogaster)
    Insecta DopR23 dopamine receptor signaling pathway
    dopamine receptor
    44(a)
    (best of 2)
      3 99B5   --
    worm
    (Caenorhabditis elegans)
    Secernentea F14D12.63 G-protein coupled receptor 42(a)   X(5644519-5646489)   --


    ENSEMBL Gene Tree for ADRA2A (if available)
    TreeFam Gene Tree for ADRA2A (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for ADRA2A gene
    HTR2A2  DRD42  HTR1A2  DRD22  HTR1F2  HTR72  HTR2B2  ADRA2C2  
    HTR2C2  HTR1D2  ADRA2B2  DRD32  HTR1E2  HTR5A2  HTR1B2  
    3 SIMAP similar genes for ADRA2A using alignment to 1 protein entry:     ADA2A_HUMAN:
    ADRA2C    ADRA2B    DRD2

    ADRA2A for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/130 SNPs in ADRA2A are shown (see all 130)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 10 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1882998691,2
    --113195170(+) CCTAGC/TTGCTG 1 -- us2k10--------
    rs1807045181,2
    --113195326(+) TAGATA/TGTCCA 1 -- us2k10--------
    rs122465611,2
    C,F,H--113195466(+) TTTTGA/CGACTA 1 -- us2k127Minor allele frequency- N:0.00EA NA NS CSA WA 3516
    rs111954181,2
    C,F,H--113195516(+) GGGCTA/GTAGAC 1 -- us2k110Minor allele frequency- G:0.04NS EA NA 1144
    rs5216741,2
    C,F,A,H--113195947(+) CCTTAA/TTGAAG 1 -- us2k1 tfbs316Minor allele frequency- T:0.47EA NA NS WA 1422
    rs1385666371,2
    --113196000(+) GAGTGA/GAGTCT 1 -- us2k10--------
    rs1864903691,2
    --113196044(+) CCAGCA/TAGCCA 1 -- us2k10--------
    rs1147778411,2
    F--113196254(+) GGCAGG/CGTGCA 1 -- us2k11Minor allele frequency- C:0.03WA 118
    rs1909277971,2
    C--113196270(+) AACTCC/TGGGTT 1 -- us2k10--------
    rs794817251,2
    C,F--113196349(+) GAGACG/TGGAGG 1 -- us2k16Minor allele frequency- T:0.17NA WA CSA EA 364

    HapMap Linkage Disequilibrium report for ADRA2A (112836790 - 112840665 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 6 variations for ADRA2A:    About this table     
    Variant IDTypeSubtypePubMed ID
    nsv7549CNV Insertion18451855
    nsv896004CNV Loss21882294
    nsv527400CNV Loss19592680
    nsv896005CNV Loss21882294
    nsv825566CNV Gain20364138
    nsv7211OTHER Inversion18451855


    Human Gene Mutation Database (HGMD): ADRA2A
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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    OMIM gene information: 104210    OMIM disorders: --

    20/33 diseases for ADRA2A (see all 33):    About MalaCards
    motion sickness    dyscalculia    balanitis    orthostatic intolerance
    attention deficit hyperactivity disorder    gilles de la tourette syndrome    ocular hypotension    learning disability
    irritable bowel syndrome    mood disorder    dyspepsia    obesity, association with
    constipation    cholera    alcohol abuse    chronic fatigue syndrome
    sleep apnea    major depressive disorder    pertussis    autism spectrum disorder

    2 diseases from the University of Copenhagen DISEASES database for ADRA2A:
    Attention deficit hyperactivity disorder     Gilles de la Tourette syndrome

    ADRA2A for disorders           About GeneDecksing


    Congresses - knowledge worth sharing:  
    Alzheimer's & Parkinson's Diseases Congress (ADPD) 18 - 22 March 2015

    10 Novoseek inferred disease relationships for ADRA2A gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    attention-deficit hyperactivity disorder 66 16 19150055 (1), 16172611 (1), 16389583 (1), 10334470 (1) (see all 12)
    tourette syndrome 47.5 4 10334470 (1), 18794646 (1), 18075481 (1), 12707939 (1)
    colon carcinoma 16.5 2 9152409 (1), 8863348 (1)
    tumors 0.815 2 9344667 (1)
    schizophrenia 0.0789 7 17034020 (2), 19439247 (1), 15115947 (1), 18558152 (1)
    cholera 0 1 1848855 (1)
    mood disorders 0 2 16526032 (1), 9631415 (1)
    adenocarcinoma 0 2 1677644 (1), 8863348 (1)
    obesity 0 1 11886485 (1)
    disability 0 2 10334470 (1), 16178932 (1)

    Genetic Association Database (GAD): ADRA2A
    Human Genome Epidemiology (HuGE) Navigator: ADRA2A (114 documents)

    Export disorders for ADRA2A gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for ADRA2A gene, integrated from 9 sources (see all 376):
    (articles sorted by number of sources associating them with ADRA2A)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. The alpha 2A-adrenergic receptor gene polymorphism modifies antidepressant responses to milnacipran. (PubMed id 18794646)1, 4, 9 Wakeno M....Kinoshita T. (2008)
    2. The adrenergic receptor alpha-2A gene (ADRA2A) and neuropsychological executive functions as putative endophenotypes for childhood ADHD. (PubMed id 16869226)1, 4, 9 Waldman I.D....Friderici K. (2006)
    3. Possible involvement of alpha-2A adrenergic receptors in attention deficit hyperactivity disorder: radioligand binding and polymorphism studies. (PubMed id 16917924)1, 4, 9 Deupree J.D....Bylund D.B. (2006)
    4. Possible association of the alpha-2A adrenergic receptor gene (ADRA2A) with symptoms of attention-deficit/hyperactivity disorder. (PubMed id 16389583)1, 4, 9 Wang B....Faraone S.V. (2006)
    5. Is the alpha-2A adrenergic receptor gene (ADRA2A) associated with attention-deficit/hyperactivity disorder? (PubMed id 12815749)1, 4, 9 Roman T....Hutz M.H. (2003)
    6. Association between alpha-2a-adrenergic receptor gene and ADHD inattentive type. (PubMed id 16806103)1, 4, 9 Schmitz M....Rohde L.A. (2006)
    7. Variations in the alpha2A-adrenergic receptor gene and their functional effects. (PubMed id 16513442)1, 4, 9 Kurnik D....Stein C.M. (2006)
    8. Attention deficit hyperactivity disorder with reading disabilities: preliminary genetic findings on the involvement of the ADRA2A gene. (PubMed id 16178932)1, 4, 9 Stevenson J....Thapar A. (2005)
    9. A C-1291G polymorphism in the alpha2A-adrenergic receptor gene (ADRA2A) promoter is associated with cortisol escape from dexamethasone and elevated glucose levels. (PubMed id 11886485)1, 4, 9 Rosmond R....Bjorntorp P. (2002)
    10. A Preliminary Candidate Genotype-Intermediate Phenoty pe Study of Satiation and Gastric Motor Function in Obesity. (PubMed id 19876010)1, 4, 9 Papathanasopoulos A....Zinsmeister A.R. (2009)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 150 HGNC: 281 AceView: ADRA2A Ensembl:ENSG00000150594 euGenes: HUgn150
    ECgene: ADRA2A Kegg: 150 H-InvDB: ADRA2A

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for ADRA2A Pharmacogenomics, SNPs, Pathways
    SeattleSNPshttp://pga.gs.washington.edu/data/adra2a/

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for ADRA2A gene:
    Search GeneIP for patents involving ADRA2A

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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    About This Section

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