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ADRA2A Gene

protein-coding   GIFtS: 69
GCID: GC10P112826

Adrenoceptor Alpha 2A

(Previous names: adrenergic, alpha-2A-, receptor)
(Previous symbols: ADRA2, ADRA2R)
  See ADRA2A-related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Adrenoceptor Alpha 2A1 2     ADRAR2 3
ADRA2R1 2 3 5      Alpha-2A-Adrenergic Receptor1
ADRA21 2     ALPHA2AAR2
Adrenergic, Alpha-2A-, Receptor1 2     ZNF322
Alpha-2AAR Subtype C101 2     Alpha-2-Adrenergic Receptor, Platelet Type2
Alpha-2 Adrenergic Receptor Subtype C102 3     Alpha-2A Adrenergic Receptor2
Alpha-2A Adrenoceptor2 3     Alpha-2AAR3
Alpha-2A Adrenoreceptor2 3     

External Ids:    HGNC: 2811   Entrez Gene: 1502   Ensembl: ENSG000001505947   OMIM: 1042105   UniProtKB: P089133   

Export aliases for ADRA2A gene to outside databases

Previous GC identifers: GC10P111730 GC10P112070 GC10P112968 GC10P112501 GC10P106465


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for ADRA2A Gene:
Alpha-2-adrenergic receptors are members of the G protein-coupled receptor superfamily. They include 3 highly
homologous subtypes: alpha2A, alpha2B, and alpha2C. These receptors have a critical role in regulating
neurotransmitter release from sympathetic nerves and from adrenergic neurons in the central nervous system.
Studies in mouse revealed that both the alpha2A and alpha2C subtypes were required for normal presynaptic control
of transmitter release from sympathetic nerves in the heart and from central noradrenergic neurons; the alpha2A
subtype inhibited transmitter release at high stimulation frequencies, whereas the alpha2C subtype modulated
neurotransmission at lower levels of nerve activity. This gene encodes alpha2A subtype and it contains no introns
in either its coding or untranslated sequences. (provided by RefSeq, Jul 2008)

GeneCards Summary for ADRA2A Gene:
ADRA2A (adrenoceptor alpha 2A) is a protein-coding gene. Diseases associated with ADRA2A include motion sickness, and systolic heart failure. GO annotations related to this gene include protein kinase binding and protein homodimerization activity. An important paralog of this gene is HTR1A.

UniProtKB/Swiss-Prot: ADA2A_HUMAN, P08913
Function: Alpha-2 adrenergic receptors mediate the catecholamine-induced inhibition of adenylate cyclase through
the action of G proteins. The rank order of potency for agonists of this receptor is oxymetazoline > clonidine >
epinephrine > norepinephrine > phenylephrine > dopamine > p-synephrine > p-tyramine > serotonin = p-octopamine.
For antagonists, the rank order is yohimbine > phentolamine = mianserine > chlorpromazine = spiperone = prazosin
> propanolol > alprenolol = pindolol

summary for ADRA2A Gene:
Adrenergic alpha2 receptors (alpha2-adrenoceptors) are members of the adrenergic receptor group of
G-protein-coupled receptors that also includes alpha1A, alpha1B, alpha1D, beta1, beta2 and beta3. Adrenergic
alpha2 receptors are divided into three subtypes: alpha2A, alpha2B and alpha2C, which are widely distributed
in both the CNS and periphery. Alpha2-adrenoceptors play a role in the modulation of neurotransmission,
smooth muscle contraction and thermoregulation. A fourth pharmacological subtype, alpha2D, has been
identified in the rat which is thought to be a species ortholog of the human alpha2A subtype.

Gene Wiki entry for ADRA2A (Alpha-2A adrenergic receptor) Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000010.10  NC_018921.2  NT_030059.14  
Regulatory elements:
   Regulatory transcription factor binding sites in the ADRA2A gene promoter:
         Max1   Bach1   E47   Arnt   AREB6   E2F   E2F-1   c-Myc   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmids (see all 2): ADRA2A promoter sequence
   Search Chromatin IP Primers for ADRA2A

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat ADRA2A


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 10q25.2   Ensembl cytogenetic band:  10q25.2   HGNC cytogenetic band: 10q25.2

ADRA2A Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
ADRA2A gene location

GeneLoc information about chromosome 10         GeneLoc Exon Structure

GeneLoc location for GC10P112826:  view genomic region     (about GC identifiers)

Start:
112,836,790 bp from pter      End:
112,840,665 bp from pter
Size:
3,876 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., and/or eBioscience,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., and/or eBioscience, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: ADA2A_HUMAN, P08913 (See protein sequence)
Recommended Name: Alpha-2A adrenergic receptor  
Size: 450 amino acids; 48957 Da
4 PDB 3D structures from and Proteopedia for ADRA2A:
1HLL (3D)        1HO9 (3D)        1HOD (3D)        1HOF (3D)    
Secondary accessions: B0LPF6 Q2I8G2 Q2XN99 Q86TH8 Q9BZK1

Explore the universe of human proteins at neXtProt for ADRA2A: NX_P08913

Explore proteomics data for ADRA2A at MOPED

Post-translational modifications: 

  • Glycosylation2 at Asn10, Asn14
  • Modification sites at PhosphoSitePlus

  • See ADRA2A Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_000672.3  
    ENSEMBL proteins: 
     ENSP00000280155  
    Reactome Protein details: P08913

    ADRA2A Human Recombinant Protein Products:

    EMD Millipore Purified and/or Recombinant ADRA2A Protein
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    OriGene Protein Over-expression Lysate for ADRA2A
    OriGene Custom MassSpec
    OriGene Custom Protein Services for ADRA2A
    GenScript Custom Purified and Recombinant Proteins Services for ADRA2A
    Novus Biologicals ADRA2A Protein
    Novus Biologicals ADRA2A Lysate
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates
    Browse ProSpec Recombinant Proteins
    Browse Proteins at Cloud-Clone Corp.

     
    Search eBioscience for Proteins for ADRA2A 

    ADRA2A Antibody Products:

    Browse EMD Millipore's Extensive Line of Mono- and Polyclonal Antibodies
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    Abcam antibodies for ADRA2A
    Browse Antibodies at Cloud-Clone Corp.
    ThermoFisher Antibodies for ADRA2A
    LSBio Antibodies in human, mouse, rat for ADRA2A

    ADRA2A Assay Products:

    Browse Kits and Assays available from EMD Millipore
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    Browse R&D Systems for biochemical assays
    GenScript ADRA2A-overexpressing Cell Line for Assay
    Browse Enzo Life Sciences for kits & assays
    Browse ELISAs at Cloud-Clone Corp.
    Browse CLIAs at Cloud-Clone Corp.
    Search eBioscience for ELISAs for ADRA2A 


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    ADRA: GPCR / Class A : Adrenoceptors : alpha

    IUPHAR Guide to PHARMACOLOGY protein family classification: alpha2A-adrenoceptor
    Adrenoceptors

    4 InterPro protein domains:
     IPR017452 GPCR_Rhodpsn_7TM
     IPR002233 ADR_fam
     IPR001946 ADRA2A_rcpt
     IPR000276 GPCR_Rhodpsn

    Graphical View of Domain Structure for InterPro Entry P08913

    ProtoNet protein and cluster: P08913

    2 Blocks protein domains:
    IPB001946 Alpha-2A adrenergic receptor signature
    IPB002233 Adrenergic receptor signature


    UniProtKB/Swiss-Prot: ADA2A_HUMAN, P08913
    Similarity: Belongs to the G-protein coupled receptor 1 family. Adrenergic receptor subfamily. ADRA2A
    sub-subfamily


    Find genes that share domains with ADRA2A           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: ADA2A_HUMAN, P08913
    Function: Alpha-2 adrenergic receptors mediate the catecholamine-induced inhibition of adenylate cyclase through
    the action of G proteins. The rank order of potency for agonists of this receptor is oxymetazoline > clonidine >
    epinephrine > norepinephrine > phenylephrine > dopamine > p-synephrine > p-tyramine > serotonin = p-octopamine.
    For antagonists, the rank order is yohimbine > phentolamine = mianserine > chlorpromazine = spiperone = prazosin
    > propanolol > alprenolol = pindolol

         Genatlas biochemistry entry for ADRA2A:
    adrenergic,alpha-2A-,receptor,G protein coupled receptor superfamily,inhibiting formation of cAMP opening K+
    channels,inhibiting Ca2+ channels

         Gene Ontology (GO): Selected molecular function terms (see all 13):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0004930G-protein coupled receptor activity ----
    GO:0004935adrenergic receptor activity ----
    GO:0004938alpha2-adrenergic receptor activity ISS1354394
    GO:0005515protein binding IPI16531006
    GO:0019901protein kinase binding IPI15653687
         
    Find genes that share ontologies with ADRA2A           About GenesLikeMe


    Phenotypes:
         7 MGI mutant phenotypes (inferred from 3 alleles(MGI details for Adra2a):
     behavior/neurological  cardiovascular system  embryogenesis  homeostasis/metabolism  mortality/aging 
     nervous system  normal 

    Find genes that share phenotypes with ADRA2A           About GenesLikeMe

    Animal Models:
         MGI mouse knock-outs for ADRA2A: Adra2atm1Bkk Adra2atm1Lel

       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for ADRA2A
       inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for ADRA2A

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for ADRA2A
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for ADRA2A

    miRNA
    Products:
        
    miRTarBase miRNAs that target ADRA2A:
    hsa-mir-26b-5p (MIRT029792)

    Block miRNA regulation of human, mouse, rat ADRA2A using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate ADRA2A (see all 37):
    hsa-miR-3607-3p hsa-miR-1258 hsa-miR-30d hsa-miR-3142 hsa-miR-30a hsa-miR-3613-3p hsa-miR-23a hsa-miR-3622a-5p
    SwitchGear 3'UTR luciferase reporter plasmidADRA2A 3' UTR sequence
    Inhib. RNA
    Products:
        
    OriGene RNAi products in human, mouse, rat for ADRA2A
    Predesigned siRNA for gene silencing in human, mouse, rat ADRA2A

    Gene Editing
    Products:
    DNA2.0 Custom Protein Engineering Service for ADRA2A

    Clone
    Products:
         
    OriGene clones in human, mouse for ADRA2A (see all 9)
    OriGene ORF clones in mouse, rat for ADRA2A
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: ADRA2A (NM_000681)
    Browse Sino Biological Human cDNA Clones
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for ADRA2A
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat ADRA2A

    Cell Line
    Products:
         
    GenScript ADRA2A-overexpressing Cell Line for Assay
    Browse ESI BIO Cell Lines and PureStem Progenitors for ADRA2A 
    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ADRA2A

    Flow Cytometry
    Products:
       

     
    eBioscience FlowRNA Probe Sets ( VA1-11948 VF1-11952) for ADRA2A 


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    ADA2A_HUMAN, P08913: Cell membrane; Multi-pass membrane protein
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    plasma membrane5
    endoplasmic reticulum1
    nucleus1

    Gene Ontology (GO): Selected cellular component terms (see all 7):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005737cytoplasm IDA19477270
    GO:0005886plasma membrane TAS--
    GO:0005887integral component of plasma membrane IDA10948191
    GO:0016021integral component of membrane ----
    GO:0016323basolateral plasma membrane TAS17655843

    Find genes that share ontologies with ADRA2A           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for ADRA2A About   (see all 15)  
    See pathways by source

    SuperPathContained pathways About
    1Peptide ligand-binding receptors
    Class A/1 (Rhodopsin-like receptors)0.71
    GPCRs, Class A Rhodopsin-like0.43
    GPCR ligand binding0.71
    Neuroactive ligand-receptor interaction0.36
    G alpha (i) signalling events0.44
    2Monoamine GPCRs
    Monoamine GPCRs0.79
    Adrenoceptors0.00
    Amine ligand-binding receptors0.79
    Adrenaline signalling through Alpha-2 adrenergic receptor0.00
    3Signaling by GPCR
    Signaling by GPCR0.90
    Signal Transduction0.58
    GPCR downstream signaling0.90
    4Activation of cAMP-Dependent PKA
    Activation of cAMP-Dependent PKA0.77
    Activation of PKA through GPCR0.71
    cAMP Pathway0.77
    5Integration of energy metabolism
    Integration of energy metabolism0.75
    Regulation of Insulin Secretion0.75


    Find genes that share SuperPaths with ADRA2A           About GenesLikeMe

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    Selected Downloadable PowerPoint Slides of GeneGlobe Pathway Central Maps for ADRA2A (see all 6)
        Activation of PKA through GPCR
    AMPK Enzyme Complex Pathway
    cAMP Pathway
    Activation of cAMP-Dependent PKA
    Signaling Involved in Cardiac Hypertrophy

    1 GeneGo (Thomson Reuters) Pathway for ADRA2A
        Development Alpha-2 adrenergic receptor activation of ERK

    2 BioSystems Pathways for ADRA2A
        GPCRs, Class A Rhodopsin-like
    Monoamine GPCRs

    5 Reactome Pathways for ADRA2A
        G alpha (i) signalling events
    Adrenaline,noradrenaline inhibits insulin secretion
    Adrenaline signalling through Alpha-2 adrenergic receptor
    Adrenoceptors
    G alpha (z) signalling events

    2 PharmGKB Pathways for ADRA2A
        Antiarrhythmic Pathway, Pharmacodynamics
    Sympathetic Nerve Pathway (Neuroeffector Junction)

    1 Kegg Pathway  (Kegg details for ADRA2A):
        Neuroactive ligand-receptor interaction

        Pathway & Disease-focused RT2 Profiler PCR Arrays including ADRA2A: 
              Neurotransmitter Receptors in human mouse rat
              G Protein Coupled Receptors 384HT in human mouse rat
              Cardiotoxicity in human mouse rat

    Interactions:

        GeneGlobe Interaction Network for ADRA2A

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for ADRA2A (P089133 ENSP000002801554) via UniProtKB, MINT, STRING, and/or I2D (see all 157)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    GNAO1P094713, ENSP000002624934I2D: score=1 STRING: ENSP00000262493
    PRKCDQ056553, ENSP000003316024I2D: score=1 STRING: ENSP00000331602
    ADRB1P085883, ENSP000003583014I2D: score=2 STRING: ENSP00000358301
    ADRBK1P250983, ENSP000003122624I2D: score=2 STRING: ENSP00000312262
    GNAI1P630963, ENSP000003430274I2D: score=1 STRING: ENSP00000343027
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 47):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0001819positive regulation of cytokine production IDA17655843
    GO:0002526acute inflammatory response IEA--
    GO:0006112energy reserve metabolic process TAS--
    GO:0006260DNA replication IEA--
    GO:0006928cellular component movement TAS9624180

    Find genes that share ontologies with ADRA2A           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Compounds for ADRA2A available from Tocris Bioscience    About this table
    CompoundAction CAS #
    JP 1302 dihydrochloridePotent and selective alpha2C antagonist[80259-18-3]
    BRL 44408 maleateSelective alpha2A antagonist[118343-19-4]
    Atipamezole hydrochlorideSelective alpha2 antagonist[104075-48-1]
    Medetomidine hydrochloride Potent, highly selective alpha2 agonist [106807-72-1]
    Dexmedetomidine hydrochloride Potent, highly selective alpha2 agonist. Active isomer of medetomidine (Cat. No. 2023) [145108-58-3]

    8 HMDB Compounds for ADRA2A    About this table
    CompoundSynonyms CAS #PubMed Ids
    Epinephrine(-)-(R)-Epinephrine (see all 72)51-43-4--
    Norepinephrine(-)-(R)-Norepinephrine (see all 32)51-41-2--
    PhenylephrineAdrianol (see all 60)59-42-7--
    PhenylpropanolamineDL-Norephedrine (see all 12)154-41-6--
    Pseudoephedrine(+)-(1S,2S)-Pseudoephedrine (see all 25)90-82-4--
    Tyramine2-(4'-Hydroxyphenyl)ethylamine (see all 34)51-67-2--
    p-Octopamine(RS)-Octopamine (see all 17)104-14-3--
    p-Synephrine(+)-Synephrine (see all 3)532-80-9--

    Selected DrugBank Compounds for ADRA2A (see all 60)    About this table
    CompoundSynonyms CAS #TypeActionsPubMed Ids
    ApraclonidineApraclonidina [INN-Spanish] (see all 4)66711-21-5targetagonist17572343 14575724 12630335 16935593 11481271 17139284 17824139 17016423 15748550 16921219 20399934
    MethyldopaAlpha medopa (see all 5)555-30-6target--1363322 9284427 17139284 17016423 14557373 10415926 17485976 8743022
    NorepinephrineArterenol (see all 4)51-41-2targetagonist11306720 18064417 10742288 18680204 9836297 1980236 17139284 17016423
    Phentolamine-- 50-60-2targetantagonist12721093 1346768 12770936 16273345 10988273 17115069 7562640 6176798
    DexmedetomidineMedetomidina [Spanish] (see all 3)113775-47-6targetagonist11834617 14583739 15306201 11752127 17692748 15087625
    EpinephrineADR Adrenaline (see all 25)51-43-4targetagonist11306720 18064417 10742288 18680204 9836297 1980236
    GuanfacineGuanfacina [INN-Spanish] (see all 5)29110-47-2targetagonist10942848 1356794 17173664 11164065 15928018 20331927
    MirtazapineMepirzepine (see all 5)61337-67-5targetantagonist12523492 11607047 10793320 11939713 14628003 11931344
    Yohimbine-- 146-48-5targetantagonist17664022 16325800 10611634 10506165 17558432 12591093
    ClonidineChlornidinum (see all 6)4205-90-7targetagonist14757140 12098614 12357167 15306201 11752127

    Selected IUPHAR Ligands for ADRA2A (alpha2A-adrenoceptor) (see all 30)    About this table
    LigandTypeActionAffinityPubmed IDs
    lisuride
    AntagonistAntagonist10.312388666
    dexmedetomidine
    AgonistPartial agonist7.6 - 9.69605427 9760042 9824686
    terguride
    AntagonistAntagonist9.512388666
    [3H]RX821002
    AntagonistAntagonist8.8 - 9.57908642 8819505
    [3H]rauwolscine
    AntagonistAntagonist9.58819505 1353247
    clonidine
    AgonistPartial agonist7.2 - 9.29605427 9760042 9824686
    yohimbine
    AntagonistAntagonist8.4 - 9.27908642 7996470 1353247
    RX821002
    AntagonistAntagonist9.27996470
    [3H]MK-912
    AntagonistAntagonist8.97996470
    WB 4101
    AntagonistAntagonist7.6 - 8.97908642 7996470 1353247

    Selected Novoseek inferred chemical compound relationships for ADRA2A gene (see all 35)    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    mspi 76.3 11 11886485 (1), 16917924 (1), 9112004 (1), 16806103 (1) (see all 9)
    brimonidine 68.4 1 1645720 (1)
    oxymetazoline 66.3 1 8538858 (1)
    clonidine 63.1 1 10215641 (1)
    norepinephrine 61.6 16 12514167 (2), 18193048 (2), 12959998 (1), 16756025 (1) (see all 11)
    guanfacine 60.7 5 12351753 (4), 15115947 (1)
    epinephrine 47.5 14 18096057 (3), 16854373 (2), 8389195 (1), 7903535 (1) (see all 9)
    chloroethylclonidine 44.8 2 10438518 (1), 9495800 (1)
    methylphenidate 38.6 5 17283289 (2), 19150055 (1), 16013954 (1)
    dopamine 26.7 4 10334470 (1), 9208378 (1)

    3 PharmGKB related drug/compound annotations for ADRA2A gene    About this table
    Drug/compound PharmGKB Annotation
    atenololCA  
    dexmedetomidineCA  
    methylphenidateCA  



    Find genes that share compounds with ADRA2A           About GenesLikeMe



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for ADRA2A gene: 
    NM_000681.3  

    Unigene Cluster for ADRA2A:

    Adrenoceptor alpha 2A
    Hs.249159  [show with all ESTs]
    Unigene Representative Sequence: NM_000681
    1 Ensembl transcript including schematic representation, and UCSC links where relevant:
    ENST00000280155(uc001kzo.3)
    miRNA
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    eBioscience FlowRNA Probe Sets ( VA1-11948 VF1-11952) for ADRA2A 

    Additional mRNA sequence: 

    AF284095.1 BC035047.1 BC050414.1 

    2 DOTS entries:

    DT.101972051  DT.453118 

    Selected AceView cDNA sequences (see all 70):

    F09185 AI597708 AW075300 H89355 T16471 BM723451 AW241599 AI572103 
    AI147682 T08946 AW513366 Z40854 T34699 F03845 AI656344 BC035047 
    BM695296 AW196450 BF725007 BF725008 CB045497 F07597 AI828415 W73076 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    ADRA2A expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: --
    ADRA2A Expression
    About this image


    ADRA2A expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 5) fully expand
     
     Neural Tube (Nervous System)    fully expand to see all 3 entries
             Metencephalon
     
     Heart (Cardiovascular System)
             Atrioventricular Node Cells Atrioventricular Node
     
     Brain (Nervous System)
             Cerebellum
     
     Pancreas (Endocrine System)
     
     Prostate (Endocrine System)
    ADRA2A Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    ADRA2A Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.249159
        Pathway & Disease-focused RT2 Profiler PCR Arrays including ADRA2A: 
              Neurotransmitter Receptors in human mouse rat
              G Protein Coupled Receptors 384HT in human mouse rat
              Cardiotoxicity in human mouse rat

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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

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    This gene was present in the common ancestor of animals.

    Orthologs for ADRA2A gene from Selected species (see all 12)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Adra2a1 , 5 adrenergic receptor, alpha 2a1, 5 88.03(n)1
    92.47(a)1
      19 (49.04 cM)5
    115511  NM_007417.41  NP_031443.41 
     540451825 
    chicken
    (Gallus gallus)
    Aves ADRA2A1 adrenergic, alpha-2A-, receptor 75.57(n)
    76.23(a)
      428980  XM_004942276.1  XP_004942333.1 
    lizard
    (Anolis carolinensis)
    Reptilia ADRA2A6
    adrenoceptor alpha 2A
    69(a)
    1 ↔ 1
    3(45883473-45884828)
    zebrafish
    (Danio rerio)
    Actinopterygii adra2a1 adrenergic, alpha-2A-, receptor 65.28(n)
    67.71(a)
      266750  NM_207637.2  NP_997520.2 
    fruit fly
    (Drosophila melanogaster)
    Insecta DopR23
    CG182081
    dopamine receptor signaling pathway
    dopamine receptor3
    CG182081
    44(a)
    (best of 2)3
    57.2(n)1
    45.37(a)1
      3 99B53
    422581  NM_001275785.11  NP_001262714.11 
    worm
    (Caenorhabditis elegans)
    Secernentea F14D12.63
    octr-11
    G-protein coupled receptor3
    octr-11
    42(a)3
    47.13(n)1
    40.28(a)1
      X(5644519-5646489)3
    1844691  NM_001029398.11  NP_001024569.11 


    ENSEMBL Gene Tree for ADRA2A (if available)
    TreeFam Gene Tree for ADRA2A (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for ADRA2A gene
    HTR1A2  ADRA1B2  HTR1F2  HTR72  ADRA2C2  HTR1D2  ADRA2B2  ADRA1A2  
    HTR1E2  HTR5A2  HTR1B2  ADRA1D2  
    3 SIMAP similar genes for ADRA2A using alignment to 1 protein entry:     ADA2A_HUMAN:
    ADRA2C    ADRA2B    DRD2

    Find genes that share paralogs with ADRA2A           About GenesLikeMe



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
    About This Section

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    Selected SNPs for ADRA2A (see all 130)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 10 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1882998691,2
    --113195170(+) CCTAGC/TTGCTG 1 -- us2k10--------
    rs1807045181,2
    --113195326(+) TAGATA/TGTCCA 1 -- us2k10--------
    rs122465611,2
    C,F,H--113195466(+) TTTTGA/CGACTA 1 -- us2k127Minor allele frequency- N:0.00EA NA NS CSA WA 3516
    rs111954181,2
    C,F,H--113195516(+) GGGCTA/GTAGAC 1 -- us2k110Minor allele frequency- G:0.04NS EA NA 1144
    rs5216741,2
    C,F,A,H--113195947(+) CCTTAA/TTGAAG 1 -- us2k1 tfbs316Minor allele frequency- T:0.47EA NA NS WA 1422
    rs1385666371,2
    --113196000(+) GAGTGA/GAGTCT 1 -- us2k10--------
    rs1864903691,2
    --113196044(+) CCAGCA/TAGCCA 1 -- us2k10--------
    rs1147778411,2
    F--113196254(+) GGCAGG/CGTGCA 1 -- us2k11Minor allele frequency- C:0.03WA 118
    rs1909277971,2
    C--113196270(+) AACTCC/TGGGTT 1 -- us2k10--------
    rs794817251,2
    C,F--113196349(+) GAGACG/TGGAGG 1 -- us2k16Minor allele frequency- T:0.17NA WA CSA EA 364

    HapMap Linkage Disequilibrium report for ADRA2A (112836790 - 112840665 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 6 variations for ADRA2A:    About this table    
    Variant IDTypeSubtypePubMed ID
    nsv7549CNV Insertion18451855
    nsv896004CNV Loss21882294
    nsv527400CNV Loss19592680
    nsv896005CNV Loss21882294
    nsv825566CNV Gain20364138
    nsv7211OTHER Inversion18451855

    Human Gene Mutation Database (HGMD): ADRA2A
    Site Specific Mutation Identification with PCR Assays
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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 104210    OMIM disorders: --

    10 diseases for ADRA2A:    
    About MalaCards
    motion sickness    systolic heart failure    cholera    constipation
    orthostatic intolerance    gilles de la tourette syndrome    irritable bowel syndrome    attention deficit hyperactivity disorder
    obesity    schizophrenia

    2 diseases from the University of Copenhagen DISEASES database for ADRA2A:
    Attention deficit hyperactivity disorder     Gilles de la Tourette syndrome

    Find genes that share disorders with ADRA2A           About GenesLikeMe

    10 Novoseek inferred disease relationships for ADRA2A gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    attention-deficit hyperactivity disorder 66 16 19150055 (1), 16172611 (1), 16389583 (1), 10334470 (1) (see all 12)
    tourette syndrome 47.5 4 10334470 (1), 18794646 (1), 18075481 (1), 12707939 (1)
    colon carcinoma 16.5 2 9152409 (1), 8863348 (1)
    tumors 0.815 2 9344667 (1)
    schizophrenia 0.0789 7 17034020 (2), 19439247 (1), 15115947 (1), 18558152 (1)
    cholera 0 1 1848855 (1)
    mood disorders 0 2 16526032 (1), 9631415 (1)
    adenocarcinoma 0 2 1677644 (1), 8863348 (1)
    obesity 0 1 11886485 (1)
    disability 0 2 10334470 (1), 16178932 (1)

    Genetic Association Database (GAD): ADRA2A
    Human Genome Epidemiology (HuGE) Navigator: ADRA2A (114 documents)

    Export disorders for ADRA2A gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for ADRA2A gene, integrated from 10 sources (see all 380):
    (articles sorted by number of sources associating them with ADRA2A)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. The alpha 2A-adrenergic receptor gene polymorphism modifies antidepressant responses to milnacipran. (PubMed id 18794646)1, 4, 9 Wakeno M....Kinoshita T. (J Clin Psychopharmacol 2008)
    2. The adrenergic receptor alpha-2A gene (ADRA2A) and neuropsychological executive functions as putative endophenotypes for childhood ADHD. (PubMed id 16869226)1, 4, 9 Waldman I.D....Friderici K. (amp 2006)
    3. Possible involvement of alpha-2A adrenergic receptors in attention deficit hyperactivity disorder: radioligand binding and polymorphism studies. (PubMed id 16917924)1, 4, 9 Deupree J.D....Bylund D.B. (Am. J. Med. Genet. B Neuropsychiatr. Genet. 2006)
    4. Possible association of the alpha-2A adrenergic receptor gene (ADRA2A) with symptoms of attention-deficit/hyperactivity disorder. (PubMed id 16389583)1, 4, 9 Wang B....Faraone S.V. (Am. J. Med. Genet. B Neuropsychiatr. Genet. 2006)
    5. Is the alpha-2A adrenergic receptor gene (ADRA2A) associated with attention-deficit/hyperactivity disorder? (PubMed id 12815749)1, 4, 9 Roman T....Hutz M.H. (Am. J. Med. Genet. B Neuropsychiatr. Genet. 2003)
    6. Association between alpha-2a-adrenergic receptor gene and ADHD inattentive type. (PubMed id 16806103)1, 4, 9 Schmitz M....Rohde L.A. (Biol. Psychiatry 2006)
    7. Variations in the alpha2A-adrenergic receptor gene and their functional effects. (PubMed id 16513442)1, 4, 9 Kurnik D....Stein C.M. (Clin. Pharmacol. Ther. 2006)
    8. Attention deficit hyperactivity disorder with reading disabilities: preliminary genetic findings on the involvement of the ADRA2A gene. (PubMed id 16178932)1, 4, 9 Stevenson J....Thapar A. (J Child Psychol Psychiatry 2005)
    9. A C-1291G polymorphism in the alpha2A-adrenergic receptor gene (ADRA2A) promoter is associated with cortisol escape from dexamethasone and elevated glucose levels. (PubMed id 11886485)1, 4, 9 Rosmond R....BjAPrntorp P. (J. Intern. Med. 2002)
    10. A preliminary candidate genotype-intermediate phenotype study of satiation and gastric motor function in obesity. (PubMed id 19876010)1, 4, 9 Papathanasopoulos A....Zinsmeister A.R. (Obesity (Silver Spring) 2010)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 150 HGNC: 281 AceView: ADRA2A Ensembl:ENSG00000150594 euGenes: HUgn150
    ECgene: ADRA2A Kegg: 150 H-InvDB: ADRA2A

    (According to HUGE)
    About This Section

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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
    About This Section

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    NameDescription
    PharmGKB entry for ADRA2A Pharmacogenomics, SNPs, Pathways
    SeattleSNPshttp://pga.gs.washington.edu/data/adra2a/

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for ADRA2A gene:
    Search GeneIP for patents involving ADRA2A

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, eBioscience, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
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